Digital Commons Network^™

Enhanced Meropenem Activity And Stability Following Load In Polyvinyl Alcohol Nanofiber Scaffolds With Sitagliptin As Quorum Sensing Inhibitor On Pseudomonas Aeruginosa, Samar A. Salim, Abdelrhman Mohsen, Mohamed Emara, Taghrid Elmahdy

Nanotechnology Research Centre

Background The increasing resistance of bacteria to conventional antibiotics poses a significant health challenge. Innovative strategies, such as combining antibiotics with agents like quorum sensing inhibitors (QSIs), have been developed to combat this issue. QSIs enhance antibiotic efficacy without inhibiting bacterial growth, minimizing the risk of resistance. Aims Evaluate the combined effect of Sitagliptin (STG) as a QSI with Meropenem (MER), fabricate drug-loaded Polyvinyl Alcohol (PVA) nanofibers, and investigate their antimicrobial activity against standard Pseudomonas aeruginosa (PAO1) and carbapenem-resistant P. aeruginosa (CRPA). Methods The combinatorial effect was assessed using a checkerboard assay. PVA/STG, PVA/MER, and PVA/STG/ MER nanofibers were fabricated …

Proteogenomic Characterization Unveils Biomarkers Associated With Chemoresistance In Muscle-Invasive Bladder Cancer, Matthew V Holt, Yongchao Dou, Meggie N Young, Alexander B Saltzman, Meenakshi Anurag, Jonathan T Lei, Antrix Jain, Mei Leng, Beom-Jun Kim, Lacey E Dobrolecki, Stefanie F Faucher, Sara Savage, Chenwei Wang, Zhiao Shi, Hugo Villanueva, Karoline Kremers, Kyle D Drinnon, Patricia D Castro, Michael M Ittmann, Mehak Mehboob Khatani, Sung Han Kim, Matthew J Ellis, Bing Zhang, Anna Malovannaya, Seth P Lerner

Faculty, Staff and Students Publications

To explore potential chemoresistance mechanisms and identify therapeutic opportunities in muscle-invasive bladder cancer (MIBC), we conduct comprehensive proteogenomic characterization of 46 pre- and 14 post-treatment MIBC tumors incorporating genomics, transcriptomics, proteomics, and phosphoproteomics. Multi-omics clustering not only recapitulated established molecular subtypes but also revealed subtypes associated with chemotherapy sensitivity. Protein isoform level analysis identifies protein abundance of a short isoform of ATAD1 and RAF family proteins as biomarkers of chemosensitivity. Integration of proteomic and phosphoproteomic data reveals Wnt signaling via GSK3B-S9 phosphorylation and the JAK/STAT pathway as potential targets to overcome chemoresistance. Correlations between PD-L1 and TROP-2/NECTIN-4 indicate an additive …

Interview With Nick Angeloff, Jacey Terrill

What Happened Here

This is a transcript of an oral history interview with Nicolas Angeloff, a lecturer at Cal Poly Humboldt, Senior Research Advisor to the new director and co-directors at the Cultural Resources Facility, and an HSU alumnus. He has worked at the CRF since 1996 and has been a lecturer since 2018. He describes that he was unsurprised by a protest occurring, knowing the history of the Israel-Palestine conflict and recent escalating events. He disagrees with some protesters’ choice to aggravate the police and destroy property. He also thought the immediate police presence and subsequent reaction by protesters were unproductive. He …

The Impact Of Maternal Diabetes On Sacral Agenesis: A Paediatric Report, Gabriella M. Calabrese, Márcio L. Duarte, Leonardo F. Freitas, Eduardo O. Narvaez

Sultan Qaboos University Medical Journal

No abstract provided.

“I Feel Like A Lot Of Times Women Are The Ones Who Are Problem-Solving For All The People That They Know”: The Gendered Impacts Of The Pandemic On Women In Alaska, Marya Rozanova-Smith, Andrey N. Petrov

Faculty Publications

The impacts of the COVID-19 pandemic and post-pandemic recovery in urban communities in the Arctic have been substantial, but their gendered aspects remain largely unknown. The goal of this study was to enhance the understanding of the gender-based impact on women in the urban areas of Alaska by exploring strengths and constraints to resilience in the social and economic domains of gender equality during and in the aftermath of the COVID-19 pandemic. Drawing on grounded theory methodology, this study is based on 29 in-depth, semi-structured interviews. The study methodology utilized a conceptual framework that integrated deficit-based and strength-based analytical perspectives. …

Teaching Bilingual Learners With Dysgraphia, Angela Gonzalez-Urbina

Masters Projects

With the push for legislation on the Dyslexia law in Michigan and elsewhere, teachers need to understand what dyslexia and dysgraphia are to support all students. An extra understanding is necessary in bilingual education and reading challenges because they use two language systems in and out of the classroom. Reading and writing are already areas that impact the working memory of the learner; adding dysgraphia to that proves to be more of a challenge. Dysgraphia can coexist with dyslexia, and individuals with dysgraphia often experience difficulties with spelling and writing speed. This project introduces dysgraphia as one of the reading …

Investigation Of A Divergent Triangle Construct For Internal Fixation Of Vertical Femoral Neck Fractures Using Experimental And Finite Element Analysis Methods, Hannah Rainey

Masters Theses

Hip fractures are a significant public health issue as they are a commonly encountered problem and have a high rate of mortality. The fracture of the femoral neck is difficult to treat due to the geometry of the proximal femur and the weight-bearing capacity that the structure must comply with. Internal fixation of the femoral neck is often accomplished with three screws inserted along the axis of the femoral neck. The optimal configuration and number of these screws is not agreed upon in the literature. The purpose of this study was to conduct a pilot investigation on the biomechanical performance …

Kraemer Is 2025 Distinguished Alumni Award Recipient, Communications And Marketing

Campus News Archive

No abstract provided.

Platelet Protease-Activated Receptor 4 Genotype And Response To Aspirin In Pregnancy, Rupsa C. Boelig, James V. Michael, Antonios Tawk, Tingting Zhan, Joanna S. Y. Chan, Walter K. Kraft, Steven E. Mckenzie

Department of Medicine Faculty Papers

The platelet protease-activated receptor 4 (PAR4) threonine 120 (Thr120) allele is an activating allele associated with reduced aspirin response in vitro. Aspirin is recommended in high-risk pregnancies to prevent preeclampsia and preterm birth. We evaluated the impact of PAR4 genotype on aspirin response in pregnancy, as measured by platelet function assay 100 (PFA-100) epinephrine closure time, and perinatal outcomes. We conducted a prospective cohort study of high-risk pregnant patients who took 81-mg aspirin daily. PFA-100 was assessed at baseline, 2 to 4 weeks after aspirin initiation (follow-up 1), and 28 to 32 weeks’ gestation (follow-up 2). Primary outcome was difference …

Global Drivers And Local Management Of Groundwater Stress: A High-Resolution Economic Analysis Of Land, Water, And Food Systems, Iman Haqiqi, Thomas Hertel, Kavitha Srikanth

Department of Agricultural Economics Faculty Publications

Groundwater stress, a critical challenge for global water security and food production, has intensified due to the interaction of global change drivers and rapidly evolving local conditions. This paper investigates the individual and combined impacts of water availability, heat, population growth, income dynamics, and technological advancements on global groundwater stress over a historical period from 1997 to 2017. Utilizing the gridded Simplified International Model of agricultural Prices, Land use, and the Environment (SIMPLE-G), the study attributes local changes in water and land use patterns to these key global drivers. Furthermore, it evaluates an alternative, counterfactual scenario in which sustainable management …

Putting Genai On Notice: Genai Exceptionalism And Contract Law, David Atkinson

NULR Online

No abstract provided.

Development Of A New Ground-Based Instrumentation Technique For Low-Resolution Exoplanet Transmission Spectroscopy, Mary Anne Limbach, Luke M. Schmidt, Ryan J. Oelkers, Darren L. Depoy

Physics & Astronomy Faculty Publications

We present a new instrumentation technique for high-precision, ground-based spectrophotometric measurements ideal for low-resolution (R ∼ 20–60) exoplanet transmission spectroscopy. This technique employs novel thin-film coating technology for wide-band, simultaneous multi-band imaging, enabling high-precision differential photometry through self-referencing and comparison stars. Theoretical calculations and on-sky results show that this method effectively reduces 96% of amplitude scintillation noise and other systematics that typically limit ground-based spectrophotometric precision for bright stars. On-sky results are demonstrated using the custom-built Exoplanet Transmission Spectroscopy Imager (ETSI), deployed at the McDonald Observatory 2.1 m telescope in 2022. For a V = 9.7 mag star, ETSI …

Nurse-Initiated Improvement For Documentation Of Penicillin Adverse Drug Reactions In Pediatric Urgent Care Clinics., Elizabeth Monsees, Diane Petrie, Rana El Feghaly, Sarah Suppes, Brian R. Lee, Megan Whitt, Amanda Nedved

Manuscripts, Articles, Book Chapters and Other Papers

Background/Objective: Penicillin allergy labels (PALs) contribute to broad-spectrum antibiotic use. Thorough documentation can help prescribers identify and remove unnecessary PALs. We aimed to improve documentation of PALs in three pediatric urgent care (PUC) clinics, using a nurse-initiated quality improvement (QI) approach. Methods: QI interventions included a survey to assess prescriber and nurse confidence, an online educational module, and an algorithm to aid in clarifying PALs. We measured the percentage of PALs with a clarified reaction severity as our primary outcome using annotated control charts. Descriptive and inferential statistics evaluated survey responses between nurses and prescribers. Results: Clarified PAL reaction severity …

Dna Methylation Signatures Of Cardiovascular Health Provide Insights Into Diseases, Madeleine Carbonneau, Yi Li, Yishu Qu, Yinan Zheng, Alexis C Wood, Mengyao Wang, Chunyu Liu, Tianxiao Huan, Roby Joehanes, Xiuqing Guo, Jie Yao, Kent D Taylor, Russell P Tracy, Peter Durda, Yongmei Liu, W Craig Johnson, Wendy S Post, Tom Blackwell, Jerome I Rotter, Stephen S Rich, Susan Redline, Myriam Fornage, Jun Wang, Hongyan Ning, Lifang Hou, Donald Lloyd-Jones, Kendra Ferrier, Yuan-I Min, April P Carson, Laura M Raffield, Alexander Teumer, Hans J Grabe, Henry Völzke, Matthias Nauck, Marcus Dörr, Arce Domingo-Relloso, Amanda Fretts, Maria Tellez-Plaza, Shelley A Cole, Ana Navas-Acien, Meng Wang, Joanne M Murabito, Nancy L Heard-Costa, Brenton Prescott, Vanessa Xanthakis, Dariush Mozaffarian, Daniel Levy, Jiantao Ma

Faculty, Staff and Students Publications

Background: The association of overall cardiovascular health (CVH) with changes in DNA methylation (DNAm) has not been well characterized.

Methods: We calculated the American Heart Association's Life's Essential 8 score to reflect CVH in 5 cohorts with diverse backgrounds (mean age 54 years, 55% women, and enrollment year ranging from 1989 to 2012). Epigenome-wide association studies (EWAS) for Life's Essential 8 score were conducted, followed by bioinformatic analyses. DNAm loci significantly associated with Life's Essential 8 score were used to calculate a CVH DNAm score. We examined the association of the CVH DNAm score with incident cardiovascular disease (CVD), cardiovascular …

Corticotropin-Releasing Hormone Modulates Nrem Sleep Consolidation Through The Thalamic Reticular Nucleus, Loredana Cumpana, Olivia Zanoletti, Dinesh Kankanamge, Bryan Copits, Carmen Sandi, Simone Astori

2020-Current year OA Pubs

Corticotropin-releasing hormone (CRH) is a peptide associated with stress and anxiety that acts as a potent modulator throughout the nervous system. The thalamic reticular nucleus (TRN) displays high expression of the CRH receptor 1 (CRHR1), but whether CRH modulates key TRN functions, such as sleep spindle rhythmogenesis, remained unexplored. Combining polysomnographic and photometric recordings in mice, we show that CRH release in TRN during non-rapid-eye movement sleep (NREMS) oscillates with a ~50-s periodicity, anti-correlating with sleep spindle dynamics. Optogenetic manipulations of CRH release in TRN modulated NREMS fragmentation through microarousals with corresponding changes in sigma and delta power. In ex-vivo …

Heart Failure And Death In Older Adults With Elevated Cardiac Biomarkers But Without Risk Factors: The Atherosclerosis Risk In Communities Study, Xiaoming Jia, Mahmoud Al Rifai, Chiadi Ndumele, Amil Shah, Elizabeth Selvin, Salim S Virani, Ron C Hoogeveen, Biykem Bozkurt, Christie M Ballantyne, Vijay Nambi

Faculty, Staff and Students Publications

No abstract provided.

Changes In Self-Reported Excessive Daytime Sleepiness Are Associated With 5-Year All-Cause Mortality Risk Among Veterans, Katherine G Bay, Arash Maghsoudi, Amin Ramezani, Drew A Helmer, Amir Sharafkhaneh, Javad Razjouyan

Faculty, Staff and Students Publications

Excessive daytime sleepiness (EDS) is linked to adverse clinical outcomes. This study evaluated changes in a validated tool to assess EDS, the Epworth Sleepiness Scale (ESS) and mortality risk. This retrospective cohort study included Veterans receiving sleep-related services in the Department of Veterans Affairs (VA) from October 4, 1999 to August 18, 2018, with two qualifying ESS measures. ESS values were extracted from patient notes using a validated natural language processing (NLP) pipeline (96% accuracy). ESS scores were categorised as Normal (0-10) or Abnormal (11-24). Patients were grouped based on ESS changes: Normal-Normal, Normal-Abnormal, Abnormal-Abnormal and Abnormal-Normal. Cox proportional hazards …

Quantifying Collective Interactions In Biomolecular Phase Separation, Hannes Ausserwöger, Ella De Csilléry, Daoyuan Qian, Georg Krainer, Timothy J Welsh, Tomas Sneideris, Titus M Franzmann, Seema Qamar, Nadia A Erkamp, Jonathon Nixon-Abell, Mrityunjoy Kar, Peter St George-Hyslop, Anthony A Hyman, Simon Alberti, Rohit V Pappu, Tuomas P J Knowles

2020-Current year OA Pubs

Biomolecular phase separation is an emerging theme for protein assembly and cellular organisation. The collective forces driving such condensation, however, remain challenging to characterise. Here we show that tracking the dilute phase concentration of only one component suffices to quantify composition and energetics of multicomponent condensates. Applying this assay to several disease- and stress-related proteins, we find that monovalent ions can either deplete from or enrich within the dense phase in a context-dependent manner. By analysing the effect of the widely used modulator 1,6-hexanediol, we find that the compound inhibits phase separation by acting as a solvation agent that expands …

Exploring Neuropsychiatric Manifestations Of Vitamin B Complex Deficiencies, Anamaria Han, Leandro Almeida, Nikhilesh Anand, Ihsan Salloum, Salim Kanaan, Bharathi Gadad, João Paulo Lima Daher

School of Medicine Publications

B complex vitamins, a group of eight water-soluble vitamins, play interconnected roles in maintaining nervous system health. Thiamine (B1), riboflavin (B2), and niacin (B3) are essential as co-enzymes in numerous metabolic reactions related to energy production. Thiamine is involved in the Krebs cycle, riboflavin in the electron transport chain, and niacin plays a key role in both glycolysis and the Krebs cycle. These metabolic processes are vital for sustaining the integrity of the nervous system, as the energy produced is critical for the functioning of nerve cells. Deficiencies in these vitamins can lead to significant neurological and psychiatric conditions, including …

Gm-Csf Production By Immune Cells In Steady State And Autoimmune Neuroinflammation Mapped Using Fate Reporting Mice, Gholamreza Azizi, Javad Rasouli, Hamed Naziri, Michael V. Gonzalez, James Garifallou, Guang-Xian Zhang, Bogoljub Ciric, Abdolmohamad M. Rostami

Department of Neurology Faculty Papers

INTRODUCTION: GM-CSF is a pro-inflammatory cytokine that promotes an inflammatory phenotype in myeloid cells. The extent and pattern of GM-CSF expression in immune cells have not been fully elucidated. Our goal was to advance this topic using novel GM-CSF reporter/fate reporter transgenic mice.

METHODS: We tracked ongoing and past GM-CSF expression in various immune cells from multiple organs, in steady-state and autoimmune inflammation of the central nervous system (CNS).

RESULTS: The GM-CSF expression patterns varied by cell type and organ, with CD4

DISCUSSION: These findings identified distinct GM-CSF cellular sources across organs, highlighting the transient nature of GM-CSF expression and …

Towards Scalable Schema Mapping Using Large Language Models, Christopher Buss, Mahdis Safari, Arash Termehchy, David Maier, Stefan Lee

Computer Science Faculty Publications and Presentations

The growing need to integrate information from many diverse sources poses significant scalability challenges for data integration systems. These systems often rely on manually written schema mappings, which are complex and costly to maintain. While recent advances suggest that large language models (LLMs) can assist in automating schema mapping, key challenges remain. We motivate future research in schema mapping generation by highlighting key challenges, presenting a competitive bidirectional schema matching pipeline, and exploring the limitations of current methods for generating more complex mappings.

Experience-Dependent Intrinsic Plasticity In Layer Iv Of Barrel Cortex At Whisking Onset, Molly C Shallow, Lucy Tian, Bryan T Higashikubo, Hudson Lin, Katheryn B Lefton, Siyu Chen, Joseph D Dougherty, Joe P Culver, Mary E Lambo, Keith B Hengen

2020-Current year OA Pubs

The development of motor control over sensory organs is a critical milestone, enabling active exploration and shaping of the sensory environment. Whether the onset of sensory organ motor control directly influences the development of corresponding sensory cortices remains unknown. Here, we confirm and exploit the late onset of whisking behavior in mice to address this question in the somatosensory system. Using ex vivo electrophysiology, we describe a transient increase in the intrinsic excitability of excitatory neurons in layer IV of the barrel cortex, which processes whisker input, immediately following the onset of active whisking on postnatal days 13 and 14. …

The Perceived Impact Of Officer-Involved Domestic Violence On Law Enforcement Administrators, Victoria Smith

Walden Dissertations and Doctoral Studies

The frequency of officer-involved domestic violence (OIDV) is a serious problem in the law enforcement profession. This qualitative phenomenological study aimed to determine what measures and specific domestic violence policies are working well and what is working poorly in Florida. This study is critical because it can aid upcoming law enforcement administrators (LEAs) and current LEAs in improving the policies and measures they use in their agency to combat OIDV among their officers and recruits. Jacques’s organizational culture theory (OCT) provided a framework for this study. I used purposeful snowball sampling methods to recruit participants for this study. Six law …

Strategies To Improve Psychiatrist Understaffing In Psychiatric Hospitals In Rural And Underserved Communities: Addressing Administrative Challenges, Carla Aramouni

Walden Dissertations and Doctoral Studies

Psychiatric hospitals across the United States face a worsening shortage of psychiatrists, particularly in rural and underserved communities, which limits timely mental health care, increases wait times, and places unsustainable strain on the psychiatric workforce. The purpose of this integrative review was to identify administrative strategies that can mitigate psychiatrist understaffing and support sustainable care delivery in psychiatric hospitals. An integrative review methodology was used to explore both empirical and nonempirical literature, resulting in 92 articles, including 32 peer-reviewed sources and several supporting studies selected through a systematic search, screening, and critical appraisal. Thematic analysis of the evidence revealed five …

Echocardiographic Assessment Of Pulmonary Hemodynamics And Right Ventricular Performance In Neonatal Murine Hypoxia, Kel Vin Woo, Philip T Levy, Carla J Weinheimer, Amanda L Hauck, Aaron Hamvas, David M Ornitz, Attila Kovacs, Gautam K Singh

2020-Current year OA Pubs

No abstract provided.

Promising Practices To Address Healthcare Needs Voiced By Local Native Americans, Noelle Taylor, Mykin R. Higbee, Raiden Gaul

Transforming Communities

Purpose

To examine barriers and facilitators to nursing education among Native Americans and identify evidence-based strategies to increase the number of Native American nurses working in their local communities to address health disparities.

Background

Native Americans experience significantly higher rates of chronic illnesses such as diabetes and heart disease, and lower life expectancies. Only 4% of registered nurses identify as Native American, with no growth despite increased funding for diversity in nursing education. This underrepresentation contributes to culturally insensitive care and persistent healthcare inequities stemming from historical marginalization and trauma.

Methods

A comprehensive literature review was conducted using CINAHL, PubMed, …

Use Of Ict In South African Schools And The Plight Of Marginalized Learners During The Covid-19 Pandemic, Chinegbonkpa Hope Nwakanma, Maryam Chinasa Adewunmi

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

Given that information and communication technology is still a luxury for poor students, especially in developing countries like South Africa. It is crucial to examine the extent of the inequalities and social marginalisation learners face due to lack of access to ICT, as well as the impact on their learning. This study, therefore, explores the use of ICT in public schools by synthesising existing literature on its effect on the teaching and learning of socially and economically marginalised learners. Using the qualitative research approach involving document analysis and literature review, this study reveals that lack of resources, skills and the …

Three New Species Of Androctonus From Morocco (Arachnida: Scorpiones: Buthidae), František Kovařík, Graeme Lowe, František Šťáhlavský

Euscorpius

New data are presented on the taxonomy and distribution of the dark species of the genus Androctonus Ehrenberg, 1828 in Morocco and Western Sahara. Three new species, A. argoubi sp. n., A. stockmanni sp. n., and A. vaneki sp. n. from Morocco are described, characterized by having metasoma I–IV ventrally punctate, a character that is well developed in A. stockmanni sp. n., and A. vaneki sp. n., and weakly developed in A. argoubi sp. n. Dark species from Morocco are compared with A. sergenti Vachon, 1948, and A. bourdoni Vachon, 1948. We describe and compare their …

Validity And Reliability Of The 'Feelfit®' Accelerometer In Evaluating Physical Activity And Sedentary Time In Children: A Comparative Study With Two Different Accelerometers, Songdhasn Chinapong, Korntawat Klinchan, Hanif Abdul Rahman, Michael Chia, Waris Wongpipit, Jetsada Arnin, Areekul Amornsriwatanakul

International Journal of Exercise Science

International Journal of Exercise Science 18(2): 794-810, 2025. Accurate physical activity (PA) measurement is crucial for public health surveillance. While self-report questionnaires are commonly used, they have limitations, especially in young children. An affordable and user-friendly device like Feelfit® offers a promising alternative particularly for countries with limited research resources. This study aimed to evaluate Feelfit®’s performance against the widely used ActiGraph® accelerometer in measuring PA among children. A quasi-experimental design was applied. Thirty-nine children (19 boys; 20 girls; aged 11.4 ± 0.5 years) wore both Feelfit® and ActiGraph® during sequentially specified activities of varying intensity ranging from sedentary to …

The Shorthorn: April 28, 1977

The Shorthorn Newspaper Collection: 1970s

No abstract provided.