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From Failure To Fidelity: Enabling Scalable Sim2real Lidar Perception Through Realistic Digital Twins, Muhammad Shahbaz Aug 2025

From Failure To Fidelity: Enabling Scalable Sim2real Lidar Perception Through Realistic Digital Twins, Muhammad Shahbaz

Graduate Thesis and Dissertation post-2024

LiDAR technology plays a key role in enabling intelligent perception across urban systems. Its ability to capture accurate 3D data regardless of lighting conditions makes it well-suited for applications in autonomous vehicles, traffic monitoring, security, and privacy-aware smart city infrastructure, offering advantages over camera-based systems in depth, precision, and reliability. However, scaling deployment faces substantial challenges due to the time, effort, and cost of gathering and labeling LiDAR data used to train and test perception algorithms. This dissertation addresses these challenges by tracing a comprehensive research trajectory from early failures to a successful, fidelity-driven solution. Initially, (1) it explores transfer …


American Muslim Women’S Experiences With Pregnancy And Childbirth In The United States Healthcare System, Salema Mohamed Aug 2025

American Muslim Women’S Experiences With Pregnancy And Childbirth In The United States Healthcare System, Salema Mohamed

Graduate Thesis and Dissertation post-2024

Muslim women adhere to specific religious beliefs and practices, which can inform their healthcare decisions and requirements during pregnancy and childbirth. Despite an increase in the Muslim population in the U.S., there is currently limited research on Muslim women's maternity care and experiences. To address the gaps in knowledge, this study explored Muslim women’s experiences with pregnancy and childbirth in the U.S. Data consists of interviews from 20 Muslim women who had pregnancy and childbirth in the U.S. A thematic analysis was used to analyze and report the findings. The findings revealed that modesty was a significant concern during pregnancy …


“Rights Not Rescue”: How Stigma Influences Harmful Legislation Toward Sex Workers In The Deep South, Abigail Mckenzie Conover Aug 2025

“Rights Not Rescue”: How Stigma Influences Harmful Legislation Toward Sex Workers In The Deep South, Abigail Mckenzie Conover

Graduate Thesis and Dissertation post-2024

In the United States, while prostitution or sex work is not explicitly illegal at a federal level, certain characteristics have been criminalized, mainly in indirect ways. This is significant when considering the different ways that sex work is regarded (both positively and negatively) at an institutional level. The current study examines the potential correlation between structural/institutional stigma regarding sex work/sex workers and legislation meant to directly or indirectly harm sex workers. The overall goal of this research was to answer the following question: How does structural/institutional stigma against sex workers present itself in legislation? To accomplish this, I conducted a …


The Association Between The Social Determinants Of Health And Shared Decision Making: An Investigation Of The National Survey Of Children's Health, Vernon T. Headley Aug 2025

The Association Between The Social Determinants Of Health And Shared Decision Making: An Investigation Of The National Survey Of Children's Health, Vernon T. Headley

Graduate Thesis and Dissertation post-2024

Objective: Shared decision-making (SDM) is defined as a clinical approach that allows both physicians and patients to communicate on the best treatment options that will improve the patient's overall health outcomes. Shared decision-making plays a vital role in how parents engage with their physicians regarding the healthcare needs of their children. This dissertation assessed the association between the social determinants of health and shared decision-making regarding children’s health-related issues.

Methods: The data for the current research were the National Survey of Children’s Health (NSCH), combined 2017-2020. The dependent variable was shared decision-making and included discussing treatment options, raising concerns regarding …


Podcast Narratives Of Cybercrime Perpetration, Rebeka Rocco Aug 2025

Podcast Narratives Of Cybercrime Perpetration, Rebeka Rocco

Graduate Thesis and Dissertation post-2024

The growth of the internet and cybertechnology has created the opportunity for new types of crime. Given the recency of these developments, little is known about cybercrime perpetration and there is scant existing data gathered from those who have perpetrated cybercrime. This project applied thematic analysis to 30 episodes of a popular podcast focused on cybercrime to explore pathways men take to committing and continuing to commit cybercrimes against networks and information, financial cybercrime, and sales of products on illegal online marketplaces. Findings suggest that podcast narratives of perpetration reveal shifting motivations, gradual immersion in online deviant and criminal communities, …


Rna’S Symphony: Harmonizing Splice Junctions And Exon Counts For A Novel Approach To Differential Splicing Analysis, Jelard Aquino Aug 2025

Rna’S Symphony: Harmonizing Splice Junctions And Exon Counts For A Novel Approach To Differential Splicing Analysis, Jelard Aquino

UNLV Theses, Dissertations, Professional Papers, and Capstones

Alternative Splicing (AS) plays a critical role in transcriptome complexity and cell-type-specific gene regulation, yet its analysis remains methodologically fragmented, especially in the context of noisy and sparse single-cell RNA sequencing (scRNA-seq) data. This dissertation addresses key computational challenges in AS detection by evaluating existing tools, developing integrative frameworks, and proposing new strategies for improving analysis accuracy in both bulk and single-cell contexts. In chapter 1, I present a comprehensive literature review of computational tools designed for detecting and quantifying AS from bulk and scRNA-seq data. This review outlines major methodological paradigms, including exon-based and splice junction-based approaches, and evaluates …


Effects Of Body Armor On Respiratory Muscle Fatigue And Muscle Blood Flow During Progressive Treadmill Marching, Kathryn Bell Aug 2025

Effects Of Body Armor On Respiratory Muscle Fatigue And Muscle Blood Flow During Progressive Treadmill Marching, Kathryn Bell

UNLV Theses, Dissertations, Professional Papers, and Capstones

Introduction: Torso-borne loads such as body armor are essential for modern military operations but impose mechanical and metabolic strain. These physiological stressors can trigger the inspiratory metaboreflex, which redirects blood flow from locomotor to respiratory muscles, further reducing muscle oxygen and endurance. While aerobic fitness has been shown to alleviate these effects, the interaction between sex, aerobic capacity, and oxygenation under load is not well understood. This study examined the physiological effects of torso-borne load carriage on respiratory muscle fatigue, skeletal muscle oxygenation, and exercise performance to volitional exhaustion and the degree to which sex and aerobic capacity influence these …


Hot Spring Associated Infectious Diseases In The Great Basin And Southwest, Matthew Bentz Aug 2025

Hot Spring Associated Infectious Diseases In The Great Basin And Southwest, Matthew Bentz

UNLV Theses, Dissertations, Professional Papers, and Capstones

Like all bodies of freshwater, natural hot springs can harbor pathogenic microorganisms that carry the threat of infectious disease. The unique chemistry, increased temperature, and popularity for bathing may alter the risk profile of hot springs compared to other natural bodies of water. Despite this risk, the role of hot springs as a reservoir for infectious diseases remains understudied, particularly within the context of regional public health. Nevada and the Great Basin/Southwest have increasingly promoted hot springs for the purposes of tourism, and they share a strong link to the cultural heritage of the region. The unknown risk profile and …


An Examination Of The Purity Culture Beliefs Scale And The Interaction Of Religiosity, Purity Culture Beliefs, And Pornography Use In A Census-Matched United States Sample, Kaelyn R. Griffin Aug 2025

An Examination Of The Purity Culture Beliefs Scale And The Interaction Of Religiosity, Purity Culture Beliefs, And Pornography Use In A Census-Matched United States Sample, Kaelyn R. Griffin

UNLV Theses, Dissertations, Professional Papers, and Capstones

The impacts of purity culture have been documented in the prevalence of abstinence-only sex education, perception of personal value tied to virginity, and shame and guilt related to sexual behavior. Similarly, models of moral incongruence often examine religiosity as a contributor of distress related to sexual behavior and pornography use, likely tapping into the influence of purity culture without directly naming its presence. This distinction is crucial due to the variety of religious beliefs and practices, some including purity culture and those without sexually restrictive beliefs and practices. Despite this, standardized measures for researching purity culture are limited. Ortiz (2018) …


Assessing The Impact Of Cdbg And Home Block Grants On Housing Affordability In The Las Vegas–Henderson–Paradise Metropolitan Statistical Area, David Hasan Aug 2025

Assessing The Impact Of Cdbg And Home Block Grants On Housing Affordability In The Las Vegas–Henderson–Paradise Metropolitan Statistical Area, David Hasan

UNLV Theses, Dissertations, Professional Papers, and Capstones

This dissertation aimed to analyze the impacts of aggregated federal funding from the CDBG and HOME block grants on temporal changes in the Housing Affordability Index (HAI Change). The temporal change in Housing Affordability between 2011–2015 and 2016–2020 was constructed as the dependent variable to measure the direct and indirect impacts of CDBG/HOME funding. Therefore, this dissertation seeks to identify the impacts of aggregated funding on changes in housing affordability and to explore spatial spillover effects through spatial dependencies that may influence housing affordability change as a dependent variable. The geographical area of this study is the Las Vegas–Henderson–Paradise MSA, …


Functional Biopolymers Applied To Sustainable Technologies In The Environment And Healthcare, Fengjie He Aug 2025

Functional Biopolymers Applied To Sustainable Technologies In The Environment And Healthcare, Fengjie He

UNLV Theses, Dissertations, Professional Papers, and Capstones

Biodegradable polymeric materials (biopolymers) are naturally derived materials known for their excellent biocompatibility, biodegradability, sustainability, and versatile chemical functionality. They have attracted increasing attention in various applications as alternative to synthetic materials ranging from food packaging to tissue engineering. Meanwhile, with intrinsic advantages, biopolymers have also emerged as promising materials in addressing contemporary challenges in both biomedical and environmental fields. Motivated by the significant potential of biopolymers and the growing need for sustainable materials, my research focuses on the design and engineering of biodegradable polymers with novel modification methods and application directions. In this work, two representative biopolymers are selected: …


Housewerk: How Drag Performers Engage In Emotional Labor While Navigating Community Care, Steph O. Landeros Aug 2025

Housewerk: How Drag Performers Engage In Emotional Labor While Navigating Community Care, Steph O. Landeros

UNLV Theses, Dissertations, Professional Papers, and Capstones

This dissertation examines drag performance as a form of service labor shaped by emotional labor, community care, and identity-based inequality. Drawing on interviews with drag performers shows how drag labor blends artistic skill, emotional regulation, interpersonal care, and entrepreneurial labor. While these demands mirror service sector roles in other industries, drag remains underrecognized and undervalued, particularly for performers who do not conform to white, cisgender norms. The study introduces Housewerk—an adaptation of Marlon Bailey’s concept of housework (Bailey, 2013)—to describe the mix of paid and unpaid labor drag performers engage in. Housewerk captures how performers must balance self-preservation (branding, income, …


Identifying Appropriate Clinical Cutoffs For Traumatic Dissociation In Maltreated Youth, Amanda L. Mraz Aug 2025

Identifying Appropriate Clinical Cutoffs For Traumatic Dissociation In Maltreated Youth, Amanda L. Mraz

UNLV Theses, Dissertations, Professional Papers, and Capstones

Maltreated youth who experience traumatic dissociation are at an increased risk for various severe psychopathological outcomes. Much is still unknown about the risk factors for traumatic dissociation in maltreated youth. The present study aimed to identify dissociation (e.g., dissociative amnesia, absorption and imaginative involvement, passive influence, and depersonalization and derealization) risk factors, via parametric statistical methods, in association with the appropriate clinical cutoff for the total and subscale scores from the Adolescent Dissociative Experiences Scale (A-DES). Investigatory variables included demographic (e.g., age, race, and gender), cognitive (e.g., resiliency and posttraumatic cognitions), and psychological (e.g., posttraumatic stress disorder, anxiety, and depression …


Investigating Information Extraction And Language Models In Medical Domain Text Processing, Pouyan Nahed Aug 2025

Investigating Information Extraction And Language Models In Medical Domain Text Processing, Pouyan Nahed

UNLV Theses, Dissertations, Professional Papers, and Capstones

This dissertation demonstrates that carefully adapted language-model pipelines can transform unstructured clinical-trial and pharmacological prose into reliable, low-latency structured data. Four interconnected studies support this claim.Tri-AL platform. An open-source dashboard ingests all 440 k+ ClinicalTrials.gov records—including every historical revision—into a normalized schema and parses the 20 GB XML archive over 10x faster than a BeautifulSoup baseline, while exposing hooks for demographic analytics and supporting integration of user-defined modules. Clinical trial summarization. An encoder–decoder model is trained on 57k description–summary pairs to condense clinical trials into a few sentences. ROUGE evaluation shows a 20% improvement over the baseline, while graph-based evaluation …


Pylro: A Python Calculator For Analyzing Long-Range Structural Order, Kevin Parrish Aug 2025

Pylro: A Python Calculator For Analyzing Long-Range Structural Order, Kevin Parrish

UNLV Theses, Dissertations, Professional Papers, and Capstones

We present PyLRO, an open-source Python calculator designed to detect, quantify, and display long-range order in periodic structures. The program’s design methodology, workflow, and approach to order quantification are thoroughly described and demonstrated using a simple toy model. Great care is considered in the detailing of the calculation logic, as is standard in the development of computational methods. Additionally, we apply PyLRO to a series of metastable AlPO4 structural intermediates from a prior high-pressure study, demonstrating how to compute and visualize structural order in all directions on a Miller sphere. We further highlight the program’s capabilities through a high-throughput analysis …


Tractors On The Mall: Unraveling The New Deal, Political Shifts, And The 1980s Farm Crisis, Tracy M. Neblina Aug 2025

Tractors On The Mall: Unraveling The New Deal, Political Shifts, And The 1980s Farm Crisis, Tracy M. Neblina

UNLV Theses, Dissertations, Professional Papers, and Capstones

In the 1980s, Midwestern farmers faced an economic crisis that rivaled the Great Depression. Agricultural policy in the 1970s and 1980s led to a boom and bust for many of the nation’s farmers, causing the decline in rural communities in the middle of the country. During this period, more efficient agricultural production, shifting federal policy, high inflation, and devalued farmland led farmers in the Midwest to face incredible economic hardships, loss of land, changes in their communities, and challenges to their sense of purpose and identity. The Farm Crisis of the 1980s furnishes an extraordinary opportunity to investigate a confluence …


More Than A Feeling: A Mixed-Methods Examination Of Transgender Community Connectedness And Associations With Suicidality, Erin Rook Aug 2025

More Than A Feeling: A Mixed-Methods Examination Of Transgender Community Connectedness And Associations With Suicidality, Erin Rook

UNLV Theses, Dissertations, Professional Papers, and Capstones

Transgender adults experience significantly higher rates of suicidal ideation than the general population. A sense of transgender community connectedness (STCC) may reduce this risk, but predictors of STCC and its association with suicidal ideation are understudied. This cross-sectional mixed methods study examined STCC and past-year suicidal ideation in relation to dimensions of transgender community connectedness (TCC) at each level of the Social Ecological Model using data from a U.S. survey of transgender adults (n = 126). About half (52.4%) felt connected to the transgender community, and 27.0% reported past-year suicidal ideation. Hierarchical logistic regression models for both outcomes showed good …


Nevada Hpv Vaccine Completion Time And Adherence Among 9-14-Year-Olds From 2017-2023, Emily Sandoval Aug 2025

Nevada Hpv Vaccine Completion Time And Adherence Among 9-14-Year-Olds From 2017-2023, Emily Sandoval

UNLV Theses, Dissertations, Professional Papers, and Capstones

The HPV (Human Papillomavirus) is one of the most common sexually transmitted infections, in the United States. Since its development in 1991, the HPV vaccine has been proven to be highly effective against the infection (Centers for Disease Control and Prevention [CDC], 2024). In order for an individual to receive optimal protection, the CDC has given guidelines dependent on age. It is important to understand changes in HPV vaccine completion for future public health immunization campaigns and objectives. To analyze how HPV completion and adherence has changed from 2017-2023 among the 9-14-year-old population, a retrospective cohort study was conducted utilizing …


The Compositional And Dynamical Properties Of Exoplanets, Cody James Shakespeare Aug 2025

The Compositional And Dynamical Properties Of Exoplanets, Cody James Shakespeare

UNLV Theses, Dissertations, Professional Papers, and Capstones

The solid surface density profile of protoplanetary discs, and the composition of these solids, can be formed through sequential condensation models of dust precipitating from the cooling gas of the solar nebula. I continue developing a code that reproduces the chemical compositions of most chondrites as well as the bulk compositions of the rocky planets using our partial condensation model with an evolving disc. I extend this validated code to exoplanet systems with different initial elemental ratios, like the carbon-to-oxygen ratio and estimated stellar abundances over the age of the universe. I have improved this dust condensation code to include …


School Absenteeism In Children With Disabilities: An Analysis Of School Climate And Academic Mindset, Karolyne Bastos Stucki Aug 2025

School Absenteeism In Children With Disabilities: An Analysis Of School Climate And Academic Mindset, Karolyne Bastos Stucki

UNLV Theses, Dissertations, Professional Papers, and Capstones

Students with disabilities (SWDs) are more likely to be chronically absent than general education peers (Anderson, 2021; Gee, 2018, U.S. Department of Education, 2016). Etiology for SWDs is complex with influencing factors spanning multiple ecological levels, but bolstering protective factors for SWDs may address attendance disparities. Multi-tiered systems of support (MTSS) models have the potential to address absenteeism in SWDs via school-wide preventative and/or intervention efforts (Tier 1 & 2) aimed at increasing or decreasing influencing factors in students with disabilities. School climate and academic mindset may influence students with disabilities’ attendance. The purpose of the present study was to …


An Analysis Of The Influence Of Human Disease Pathogens On Core Behaviors Of The Black-Legged Tick, Emily F. Marinko Aug 2025

An Analysis Of The Influence Of Human Disease Pathogens On Core Behaviors Of The Black-Legged Tick, Emily F. Marinko

UNLV Theses, Dissertations, Professional Papers, and Capstones

Ixodes scapularis, the black-legged or deer tick, is a vector for several different disease-causing microbes, including the causative agent of Lyme disease. As such, it is a major health concern for people living within its range in the eastern half of the United States, a habitation area that is increasing due to climate change. Despite its medical relevance as a disease vector, there is still much to learn about the basic behavior of these arachnids in the wild. Thus, the major hypothesis of this thesis is that ticks that are infected with specific human disease-causing microbes behave differently than those …


Damage Localization Of Simp Ly Supported Beams Based On Deflection Influence Surfaces Calculated By Three-Dimensional Boundary Face Method, Yin Xinfeng, Luo Zonghao, Yan Wanli, Kaiersaer ∙Tuerdi Aug 2025

Damage Localization Of Simp Ly Supported Beams Based On Deflection Influence Surfaces Calculated By Three-Dimensional Boundary Face Method, Yin Xinfeng, Luo Zonghao, Yan Wanli, Kaiersaer ∙Tuerdi

Journal of China & Foreign Highway

The deflection influence surface (DIS) of a spatial structure is difficult to calculate using the existing two-dimensional boundary element method.To address this issue,a damage localization method based on DIS calculated using the three-dimensional boundary face method (BFM ) was proposed.A custom BFM program with an internal loop was developed,and the internal forces and deformations of a square plate and a supported T-beam structure were calculated using the static method.By specifying the domain of the order of a bivariate polynomial function (BPF ),a secondary optimization program for influence surfaces was established,and the DIS with the minimum mean square error was obtained.The …


Wind Tunnel Test On Wind-Resistant Performance Of Suspended Monorail Cable-Stayed Bridge, Chen Yujiang Aug 2025

Wind Tunnel Test On Wind-Resistant Performance Of Suspended Monorail Cable-Stayed Bridge, Chen Yujiang

Journal of China & Foreign Highway

To investigate the wind-induced vibration of a suspended monorail bridge,a full-bridge aeroelastic model at a 1∶40 scale was designed and fabricated according to the geometrical parameters and dynamic characteristics of the real bridge.Wind tunnel tests on the bridge in both the completed state and the maximum cantilever state were conducted under different conditions,including uniform flow and turbulent flow,yaw angles of ± 45°,±30°,±15°,and 0°,and wind attack angles of ‒ 3°,0°,and + 3°.Both vertical and torsional displacements of the structure under different wind speeds were measured.The test results show that the vertical displacements and torsional responses of the cable-stayed bridge increase when …


Reference And Inspi Ration From Low-Carbon Development Experience Of Foreign Highway Infrastructure, Lu Chunying, Gao Shuohan, Du Xueyua N, Jian Li, Wang Xinjun, Kong Yaping Aug 2025

Reference And Inspi Ration From Low-Carbon Development Experience Of Foreign Highway Infrastructure, Lu Chunying, Gao Shuohan, Du Xueyua N, Jian Li, Wang Xinjun, Kong Yaping

Journal of China & Foreign Highway

In order to provide supp ort for the scie ntific formulation of low-carbon highway infrastructure development policies in China,empirical analysis,comparative analysis,and other methods were utilized,and the construction goals and action strategies of low-carbon highway infrastructure in the United Kingdom,the United States,and Australia were sorted out.Advanced experience in the development of low-carbon highways abroad was summarized.On this basis,combined with the current situation and existing problems of low-carbon development of China ’s highway infrastructure,the following countermeasures and suggestions were proposed:① strengthening top-level design and formulating low-carbon development goals and paths;② implementing the concept of life cycle and strengthening the research and promotion …


Walking Each Other Home: A Social Work Portfolio Of Healing, Justice, And Becoming, Serah Lander Aug 2025

Walking Each Other Home: A Social Work Portfolio Of Healing, Justice, And Becoming, Serah Lander

Graduate Student Portfolios, Professional Papers, and Capstone Projects

Abstract

This portfolio documents the integration of lived experience, academic training, and professional practice in the pursuit of a Master of Social Work (MSW) degree. Grounded in a personal history shaped by chronic illness, solo motherhood, and economic precarity, this work reframes individual challenges as symptoms of structural neglect and systemic inequity. Through reflective narrative, I explore identity development across intersecting contexts—white, queer, neurodivergent, Jewish by choice, and chronically ill—connecting personal transformation to professional readiness.

Section I: Living the Questions chronicles my evolution from navigating institutional barriers to becoming a systems thinker, crisis counselor, policy advocate, and coalition leader. This …


Kinase Suppressor Of Ras 2 Regulates Energy Balance And Tumor Initiation, Dianna H. Huisman Aug 2025

Kinase Suppressor Of Ras 2 Regulates Energy Balance And Tumor Initiation, Dianna H. Huisman

Theses & Dissertations

Kinase Suppressor of Ras 2 (KSR2) is a scaffold that facilitates Raf-MEK-ERK signaling and is expressed in the brain, pituitary, and adrenal gland. Here, we demonstrate that KSR2 functions in the adult brain to maintain organismal energy balance and in small-cell lung carcinoma (SCLC) to promote self-renewal and clonogenicity. Disruption of KSR2 in adult mice results in hyperphagia, obesity, reduced metabolic rate, and altered activity. Using spatial transcriptomics, we identify regions of the brain associated with regulation of feeding and energy expenditure with altered gene expression following KSR2 disruption. These findings reveal regions of interest in which targeted KSR2 disruption …


Scientist Perspectives: A Correlation Analysis Of Translational Science Competencies Compared With Principles Of Engagement And Knowledge Integration, Rachel Wenzl Aug 2025

Scientist Perspectives: A Correlation Analysis Of Translational Science Competencies Compared With Principles Of Engagement And Knowledge Integration, Rachel Wenzl

Theses & Dissertations

The competencies identified in the development of the “Fundamental Characteristics of the Translational Scientist” may not consider and fully integrate the concepts of knowledge integration and engagement, key components of the translational science spectrum. This gap may be widening and deepening the “valley of death” and exacerbating ongoing challenges in the field of translational science. This dissertation explored the association of knowledge integration, stakeholder engagement, and community engagement principles compared with translational science competencies.

Utilizing content review and a non-experimental, correlation study design, data were collected through a quantitative survey from adult research subjects all self-identified as a research investigator …


Beyond The Bruise: Understanding Injury Risk Factors Among Livestock Workers In Cattle Feedyards And Animal Handling Farms And Ranches, Rishad Ahmed Aug 2025

Beyond The Bruise: Understanding Injury Risk Factors Among Livestock Workers In Cattle Feedyards And Animal Handling Farms And Ranches, Rishad Ahmed

Theses & Dissertations

Cattle feeding and livestock production are central to U.S. agriculture and represent some of the most hazardous occupational environments. Workers in feedyards and on cattle farms and ranches face elevated risks of injury due to physically demanding labor, frequent animal handling, and exposure to environmental and ergonomic hazards. Many feedyard workers are Hispanic/Latino immigrants who may experience additional barriers related to language, healthcare access, and job security. Similarly, injury risks among cattle producers are compounded by seasonal workload fluctuations, limited rest opportunities, and psychosocial stressors. Beyond individual impacts, agricultural injuries also pose a substantial economic burden. Recent estimates indicate that …


Transcriptomic And Epigenomic Profiling Of Immune Cells Responses To Simian Immunodeficiency Virus Infection In The Brain, Xiaoke Xu Aug 2025

Transcriptomic And Epigenomic Profiling Of Immune Cells Responses To Simian Immunodeficiency Virus Infection In The Brain, Xiaoke Xu

Theses & Dissertations

Human immunodeficiency virus type 1 (HIV-1) is an enveloped retrovirus that significantly impairs the human immune system. A common complication of HIV-1 infection is HIV-associated neurocognitive disorder (HAND), which, prior to the introduction of antiretroviral therapy (ART), led to considerable morbidity and mortality due to untreated neuropsychiatric manifestations. Although ART has substantially reduced the incidence of HIV-associated dementia (HAD), approximately 50% of people living with HIV (PLWH) continue to experience milder forms of HAND. The CNS is seeded by HIV during the acute phase of infection. Once in the brain, HIV targets and activates resident immune cells, primarily microglia and …


Analyzing Food Access: An Investigation Of Food Insecurity Amongst Latinos In Rural Nebraska, Natalia Santos Aug 2025

Analyzing Food Access: An Investigation Of Food Insecurity Amongst Latinos In Rural Nebraska, Natalia Santos

Theses & Dissertations

Background: Food insecurity is a public health issue in the United States, with disproportionately higher rates among Latino/Hispanic households. Rural communities face unique geographical, socioeconomic, and systemic barriers that often exacerbate food access disparities. Despite the growing Latino population in rural areas, particularly in Midwestern states like Nebraska, there remains a critical gap in comprehensive research that integrates both objective and subjective understandings of their food environments. Understanding these multifaceted influences is crucial for developing effective, culturally sensitive interventions.

Problem Statement: This dissertation aims to answer the central question: How does food access and food insecurity manifest amongst Latinos in …