Digital Commons Network^™

Patient-Centered Management Of Heavy Menstrual Bleeding While On Anticoagulation: A Survey Study, Benjamin Barnett, Rushad Patell, Dana Angelini, Leben Tefera, Jordan K Schaefer, Ang Li, Alejandra Gutierrez Bernal, Shruti Chaturvedi, Anjlee Mahajan, Leslie Lake, Jori May, Anna L Parks

Faculty, Staff and Students Publications

Background: Nearly three-quarters of women experience heavy menstrual bleeding (HMB) during anticoagulation treatment for venous thromboembolism (VTE). HMB can lead to medical interventions, impact school or work and diminish quality of life (QOL). While there are several management options for HMB in patients with VTE, we lack information on how patients approach HMB treatment decisions.

Objectives: We examined patients' experience with, perceptions of, and preferences for treatment of HMB while on anticoagulation.

Methods: Clinicians and patient advocates developed a web-based survey that was distributed via patient advocacy organizations and social media between May and June 2024, targeting participants 18 years …

Optical Coherence Tomography Enables The Depth-Resolved Measurement Of Cilia Beat Frequency In Ex Vivo Human Fallopian Tubes, Dilara J Long, Tian Xia, Photini F Rice, Deirdre M Scully, Makayla Johnson, Ryan Mistifer, Andrea Aguirre, John M Heusinkveld, Irina V Larina, Jennifer K Barton

Faculty, Staff and Students Publications

Objectives: The movement of cilia in the fallopian tubes (FTs) facilitates important processes involved in fertility, and abnormalities in cilia function are linked with diseases including endometriosis and pelvic inflammatory disease. For the first time, we demonstrate the use of optical coherence tomography (OCT) to create depth-resolved mapping of motile cilia locations and quantify cilia beat frequency (CBF) in human FT samples ex vivo.

Methods: Segments of the FT ampulla were acquired from five patients following salpingectomy under an IRB approved protocol. The samples were longitudinally opened to expose the luminal surface for imaging. A sequence of at least 500 …

Microbiome Signatures And Inflammatory Biomarkers In Culture-Negative Neonatal Sepsis, Morcos Hanna, Shixia Huang, Matthew Ross, Anaid Reyes, Dimuthu Perera, Anil Surathu, Sara Javornik Cregeen, Joseph Hagan, Mohan Pammi

Faculty and Staff Publications

Overuse of antibiotics is a concern in 'culture-negative sepsis' but it is unclear whether this is due to infection with viruses, fungi or other microbes that are not easily cultured, or whether it results from inflammatory processes. In a prospective study, we enrolled 50 preterm neonates with culture-positive sepsis (CP), culture-negative sepsis (CN), and asymptomatic preterm controls (CO). The microbiome of stool, skin, and blood, including bacterial, viral and fungal components and serum cytokine profiles were evaluated. The microbiome alpha or beta diversity did not differ between CN and CO groups. A MaAsLin analysis revealed increased relative abundances of specific …

Current Controversies In Prenatal Diagnosis 2: Conventional Postmortem Examination Remains The Gold Standard For The Anatomical Examination Of Fetal Loss, J Ciaran Hutchinson, Lorraine Potocki, Ignatia B Van Den Veyver

Duncan NRI Faculty and Staff Publications

A comprehensive postmortem examination is an essential component of a work-up after stillbirth. Its findings can support accurate counseling of parents about causes and risk of recurrence. It also supports providers' decisions about most appropriate testing and management plans for future pregnancy to prevent recurrence. Informing parents about fetal autopsy and obtaining their consent is challenging, and conducting a fetal autopsy requires expertise that is, not universally available. Newer non-invasive or minimally invasive methods such as postmortem MRI and targeted biopsies can replace or supplement autopsies, but one must recognize that expertise in these methods is likewise not broadly available. …

The Effect Of Tert Promoter Mutation On Predicting Meningioma Outcomes: A Multi-Institutional Cohort Analysis, Karenna J Groff, Ruchit V Patel, Yang Feng, Hia S Ghosh, Miguel A Millares Chavez, Joseph O'Brien, William C Chen, Vijay Nitturi, Akshay V Save, Mark W Youngblood, Craig M Horbinski, James P Chandler, Felix Ehret, Chloe Gui, Justin Z Wang, Kristen Park, Sonia Ajmera, Marc Rosenblum, Abigail K Suwala, Catena Kresbach, Christopher W Mount, Ulrich Schüller, Sandro Santagata, Felix Sahm, Tejus A Bale, Christina Jackson, Timothy E Richardson, Chunyu Cai, Farshad Nassiri, Gelareh Zadeh, David Kaul, David Capper, Stephen T Magill, John G Golfinos, Chandra Sen, Akash J Patel, David R Raleigh, Jennifer Moliterno, Donato Pacione, Matija Snuderl, Wenya Linda Bi

Duncan NRI Faculty and Staff Publications

Background: Molecular aberrations have been incorporated into tumour classification guidelines of meningioma. TERT-promoter (TERTp) mutation is associated with worse prognosis and is designated a WHO grade 3 biomarker. However, it remains unclear whether TERTp mutation is context-dependent, with other co-occurring genetic alterations potentially driving its association with prognosis. We sought to characterise the role of TERTp mutation in meningioma and guide TERTp sequencing.

Methods: We identified 1492 patients of all ages who had previously received surgery for meningioma across 14 medical centres in the USA, Canada, and Germany. Patients were eligible if they had post-surgical clinical or radiographical assessment of …

The Ethics Of Clinical Ethics, Matthew Shea

Center for Medical Ethics and Health Policy Staff Publications

The concept ethics defines health care ethics as a professional practice. Yet the meaning of "ethics" is often unclear in the theory and practice of clinical ethics. Clarity on this matter is crucial for understanding the nature of clinical ethics and for debates about the professional identity and proper role of ethicists, the sort of training and skills they should possess, and whether they have ethics expertise. This article examines two different ways the ethics of clinical ethics can be understood: Real Ethics, which consists of objective moral norms grounded in moral truth; and Conventional Ethics, which consists of conventional …

Postoperative Staphylococcal Toxic Shock Syndrome In A Patient Following Right Knee Fracture Repair: A Case Report, Nicole Nyamongo, James Garritano, Daniel Rosen, Theodore Rosen

Faculty, Staff and Students Publications

Toxic shock syndrome (TSS) is a rare but life-threatening multisystem disorder most commonly caused by Staphylococcus aureus. It is characterized by the acute onset of high fever, hypotension, a diffuse macular rash, and multiorgan involvement. We report the case of a male in his late 30s who sustained a patellar fracture with associated retinacular injury following trauma and subsequently underwent open reduction and internal fixation. Several days after discharge, he developed fever, chills, hypotension, and a pruritic, erythematous rash. He was readmitted and initially evaluated by the orthopedic service, which did not recommend additional imaging or surgical intervention, as …

Diagnostic Yield Of Exome Sequencing For Pregnancies With And Without Fetal Anomalies And For Stillbirth, Roni Zemet, Christian M Parobek, April D Adams, Mohamad Ali Maktabi, Lena Shay, Linyan Meng, Pengfei Liu, Hongzheng Dai, Fan Xia, Christine Eng, Ignatia B Van Den Veyver, Liesbeth Vossaert

Duncan NRI Faculty and Staff Publications

Objective: Exome sequencing (ES) benefits the genetic work-up for fetuses with structural anomalies, but data on its utility for fetuses without anomalies and stillbirths is more limited. We report our experience with prenatal ES for all three indications.

Method: We retrospectively reviewed results from 344 trio-ES performed for fetuses with structural anomalies (N = 262), stillbirths (N = 39), and fetuses without anomalies (N = 43), many of which had a relevant family history. We classified pathogenic variants (P), likely pathogenic variants (LP), or variants of uncertain significance (VUS) favoring pathogenicity in a gene consistent with the fetal phenotype as …

The Immeasurable Value Of Plankton To Humanity, Maria Grigoratou, Susanne Menden-Deuer, Abigail Mcquatters-Gollop, George Arhonditsis, Luis Felipe Artigas, Sakina-Dorothée Ayata, Dalida Bedikoğlu, Beatrix E Beisner, Bingzhang Chen, Claire Davies, Lillian Diarra, Owoyemi W Elegbeleye, Jason D Everett, Tatiane M Garcia, Wendy C Gentleman, Rodrigo Javier Gonçalves, Tamar Guy-Haim, Svenja Halfter, Jana Hinners, Richard R Horaeb, Jenny A Huggett, Catherine L Johnson, Maria T Kavanaugh, Ana Lara-Lopez, Christian Lindemann, Celeste López-Abbate, Monique Messié, Klas Ove Möller, Enrique Montes, Frank E Muller-Karger

School of Biological and Marine Sciences

Plankton, a diverse group of aquatic organisms, make Earth livable, regulate aquatic life, and provide benefits to human societies such as access to clean water, food security, and well-being. They also support economies and inspire biotechnological innovations. This article aims to raise awareness of the value of plankton to humanity and serves as an informative guide for aquatic professionals, policymakers, and anyone interested in plankton. We present the value of plankton across six themes of human interest: biogeochemistry; ecology; climate; the evolution of science; economy; and culture, recreation, and well-being. Guided by the 2022 Intergovernmental Science-Policy Platform on Biodiversity and …

Scale Model And Ship Simulator Towing Of The Iea 15 Mw Wind Turbine On The Umaine Volturnus-S Platform, Adam Roberts, Frédéric Le Pivert, Saied Kazemi, Tom Tosdevin, Adán López-Santander, Matthew J. Craven, Lars Johanning

School of Engineering, Computing and Mathematics

Floating offshore wind turbines are expected to be deployed in significant numbers across the globe in the coming decades, with wet towing of these structures between ports and farms a key operation in their installation, maintenance, and decommissioning. Platforms are likely to be towed across large distances, and accurate understanding of tow dynamics will be crucial to optimising these journeys to minimise costs, timescales, emissions, and risk. This paper presents experimental and ship simulator modelling of the oceanic towing of the IEA 15 MW turbine on the UMaine VolturnUS-S platform. The work provides indicative data for floating offshore wind turbines …

Comparative Outcomes Following Candida Bloodstream Infection In Patients With Left Ventricular Assist Devices, Armaghan-E-Rehman Mansoor, Gayathri Krishnan, Julio C Zuniga-Moya, Benjamin Papadopoulus, Andrej Spec, Ige George

2020-Current year OA Pubs

BACKGROUND: Candida bloodstream infections (BSI) carry a high risk of adverse outcomes. Left ventricular assist devices (LVADs) are increasingly used to manage end-stage heart failure; however, they carry a risk of infection. This study evaluates the impact of LVAD presence on outcomes in patients with

METHODS: A total of 1233 patients with

RESULTS: Patients with

CONCLUSIONS: In patients with

Rezafungin Versus Caspofungin For The Treatment Of Candidemia And Invasive Candidiasis: Results From The Double-Blind, Randomized, Phase 3 Restore Trial Including The China Extension Study, George R Thompson, Haihui Huang, Sizhou Feng, Yunsong Yu, Alex Soriano, Oliver A Cornely, Bart Jan Kullberg, Peter G Pappas, Marin Kollef, Jose A Vazquez, Patrick M Honore, Laura Cox, Matteo Bassetti

2020-Current year OA Pubs

BACKGROUND: Rezafungin is approved for use in adults with candidemia and/or invasive candidiasis (IC) based on data from the ReSTORE trial (NCT03667690), which demonstrated noninferior efficacy to caspofungin. For regulatory purposes, an additional cohort of patients from China was recruited to ReSTORE. Here, we compared rezafungin and caspofungin in patients with candidemia and/or IC through analysis of the ReSTORE global data plus the China extension study.

METHODS: Adults with candidemia/IC were randomized (1:1) to receive weekly rezafungin (400/200 mg) or daily caspofungin (70/50 mg) for ≤28 days. Noninferiority was concluded for primary efficacy endpoints if the upper bound of the …

Variation In Recommended Treatment Strategies Among American Surgeons For Actual Adult Traumatic Brachial Plexus Injury Cases, Michele N Christy, Christopher J Dy, R Glenn Gaston, Bryan J Loeffler, Mihir J Desai, Steve K Lee, Harvey Chim, Jeffrey B Friedrich, Sameer K Puri, Jason H Ko, Planet Study Group

2020-Current year OA Pubs

PURPOSE: The surgical management of adult traumatic brachial plexus injuries (BPI) is challenging, with no consensus on optimal strategies. This study aimed to gather preferred reconstructive strategies from BPI surgeons for actual cases from a multicenter cohort to identify areas of agreement.

METHODS: Four case files (history, physical examination, and imaging and electrodiagnostic testing results) were distributed to eight self-designated Level IV expert BPI surgeons in the United States. Each surgeon independently reviewed the cases and provided a preferred reconstructive plan via free text response.

RESULTS: For a pan-plexus case after blunt trauma (67 years old; 3 months from injury): …

Identifying Care Gaps Along The Hiv Treatment Failure Cascade: A Multistate Analysis Of Viral Load Monitoring, Re-Suppression, And Regimen Switches In Zambia, Kombatende Sikombe, Noelle Le Tourneau, Brian Rice, Jake M. Pry, Sandra Simbeza, Laura K. Beres, Anjali Sharma, Njekwa Mukamba, Alison Wringe, James R. Hargreaves, Jacob Mutale, Carolyn Bolton Moore, Izukanji Sikazwe, Elvin Geng, Aaloke Mody

2020-Current year OA Pubs

BACKGROUND: Timely response to treatment failure is critical for improved outcomes and viral re-suppression among people living with HIV, but care gaps along the treatment failure cascade can occur due to delays by both clients (e.g., retention and adherence) and health systems (e.g., fidelity to viral load [VL] monitoring guidelines). We used multistate analysis to identify drivers of implementation gaps in the treatment failure cascade, including time to HIV VL monitoring, re-suppression, and regimen switches, in Zambia.

METHODS AND FINDINGS: We used national electronic HIV health records to identify adults on antiretroviral therapy (ART) for more than 6 months who …

Neutrophils Drive Vascular Occlusion, Tumour Necrosis And Metastasis, Jose M Adrover, Xiao Han, Lijuan Sun, Takeo Fujii, Nicole Sivetz, Juliane Daßler-Plenker, Clary Evans, Jessica Peters, Xue-Yan He, Courtney D Cannon, Won Jin Ho, George Raptis, R Scott Powers, Mikala Egeblad

2020-Current year OA Pubs

Tumour necrosis is associated with poor prognosis in cancer

Characterization Of A Mouse Model Of Osteoarticular Infection Using Clinical Isolates Of Staphylococcus Aureus, Philip M Roper, Jessica Beetner, Jennifer L Davis, Christine Shao, Jason Zhang, Linda Cox, Nitin Kumar Pokhrel, James E Cassat, Javier Rangel-Moreno, Gowrishankar Muthukrishnan, Deborah J Veis

2020-Current year OA Pubs

Osteoarticular infection, most commonly due to

From Tradition To Innovation? A Diachronic Corpus Analysis Of Simplified Technical English In Aviation, Amber Wanwen Wang, Eric Friginal

Journal of English and Applied Linguistics

Reading comprehension and fluency are fundamental for successful text processing, particularly in high-stakes environments like aviation maintenance where unclear technical documentation can have fatal consequences. This risk is amplified by the significant proportion of non-native English speakers in the global aviation maintenance workforce. While Simplified Technical English (STE) was introduced in the mid-1980s as an international specification to address these challenges and has evolved through continuous user feedback, its effectiveness in reducing text complexity and improving comprehension remains underexplored. This research examines language changes in aviation maintenance documentation from pre-1990 to 2024, analyzing linguistic variations across two generations of technical …

Examining Nurses’ Perspectives Of Organizational Strategies Designed To Enhance Job Satisfaction, Kerine J. Moodie-Brown

Walden Dissertations and Doctoral Studies

Nurse job satisfaction remains a critical issue in healthcare, as it directly impacts patient care quality, nurse retention, and organizational performance. Despite numerous organizational efforts, there is limited qualitative insight into how nurses perceive strategies aimed at improving their satisfaction. The purpose of my study, guided by Maslow’s hierarchy of needs theory, was to explore nurses’ perceptions of organizational strategies designed to enhance job satisfaction, with a particular focus on interventions such as pay incentives, workplace safety, career development opportunities, nurse residency programs, and initiatives promoting well-being. Semi-structured interviews were conducted with 10 RNs having at least 1 year of …

Stand For Support, Shatter The Silence: Administrative Approaches To Eradicate Bullying In Higher Education, Elaine M. Mora, Shawn P. Saladin

School of Rehabilitation Services & Counseling Faculty Publications

Bullying in higher education has become a widespread and complex issue that affects staff, faculty, and students worldwide, causing a detrimental impact on both psychological health and academic achievement. This paper provides a comprehensive examination of the phenomenon, encompassing all its manifestations, underlying causes, and significant consequences. The study, which draws on academic literature, outlines the various forms of bullying, including cyberbullying, mobbing, microaggressions, and social exclusion, and highlights the adverse effects these behaviors have on both individuals and academic communities. The research emphasizes how critical it is to comprehend the power relationships that exist in higher education settings and …

Plan And Track Your Performance For A Better Practice, Michelle C. Dziurgot

The Journal of the Michigan Dental Association

This editorial stresses the critical need for every dentist to track key performance indicators such as production, profit, and overhead to ensure long-term practice success. It advocates for setting and monitoring daily, weekly, and monthly goals for both doctor and hygiene departments. Strategies for effective practice management include regular team meetings, optimizing supply audits to eliminate unused materials, and planning for seasonal patient fluctuations to keep overhead in sync. The author also emphasizes the importance of providing proper training for the dental team, such as the MDA’s X-ray certification or the Certified Dental Business Professional designation, to enhance patient communication, …

J Mich Dent Assoc September 2025

The Journal of the Michigan Dental Association

Each month, The Journal of the Michigan Dental Association provides news, information, and features about Michigan dentistry to our state's oral health community and the MDA's 6,200+ members. It stands as the primary publication reaching Michigan dentists.

The September issue marks the return to a hybrid publishing schedule, with print issues published bimonthly in January, March, May, July, September, and November, and online-only digital issues in February, April, June, August, October, and December. This return to print follows a suspension in May due to association-wide financial issues, with the MDA Board of Trustees approving changes in the 2025 budget to …

Dean’S Report: Detroit Mercy Dental - Dental Schools — Safeguarding The Future Of Oral Health, Mert N. Aksu Dds, Jd, Mhsa, Cert. Dph

The Journal of the Michigan Dental Association

This report from the University of Detroit Mercy School of Dentistry highlights its mission to prepare students as clinicians, leaders, and advocates for public health and equitable access to care, emphasizing evidence-based practices and community service. It addresses critical public health measures like community water fluoridation and HPV vaccination, advocating for policies that protect oral health. The report notes concerns over proposed Michigan Medicaid dental program changes that could burden dental schools with increased uncompensated and emergency care. Initiatives to meet workforce needs include the new Detroit Mercy Dental Vermont Track and community-based education programs, which provided care to over …

Staff Matters: Can I Google Someone Before I Decide To Hire Them?, Jodi Schafer Sphr, Shrm-Scp

The Journal of the Michigan Dental Association

This Q&A addresses the practice of using Google searches to vet job applicants, cautioning that while it provides public information, it can also inadvertently reveal protected classifications (e.g., religious beliefs, race, age), making hiring decisions based on such information illegal and discriminatory. The article advises conducting internet searches after a screening interview to first establish a candidate's qualifications, which provides a defensible rationale for hiring choices. It is crucial to obtain a signed release from the applicant before conducting any background checks to ensure compliance with laws like the Fair Credit Reporting Act. The author also notes that requiring access …

Dean’S Report: U-M School Of Dentistry - Celebrating A 150-Year Tradition Of Excellence — And Planning For The Future

The Journal of the Michigan Dental Association

This report commemorates the 150th anniversary of the University of Michigan School of Dentistry, founded in 1875 largely due to the lobbying efforts of the Michigan Dental Association (MDA). It details the leadership of its first dean, Dr. Jonathan Taft, who established high professional standards that shaped the institution's commitment to excellence. The school boasts over 12,000 DDS graduates and 3,460 dental hygiene graduates, emphasizing its continuous role in advancing dentistry through innovation, research, and patient care, from early textbook development to modern digital tools like CBCTs and CAD-CAM technology. The incoming DDS Class of 2029 marks a milestone with …

September 9, 2025 Executive Board Meeting Minutes

NASIG Newsletter

No abstract provided.

Restorationland: The Lost And Found Objects Of Atlanta's Doll's Head Trail, Thomas Fish

Faculty Articles

The Doll’s Head Trail is a grassroots, low-art installation nestled within a Southeast Atlanta wildlife preserve. Constructed by volunteers and visitors from decades of environmental debris, the trail converts waste into folk art-inspired “junk” displays. The creative upcycling ranges from a miniscule shrine to “Toxic Masculinity” to a stark shoe pile commemorating child gun violence. This article details how queer theory’s “temporal turn” provides insights into material performance as collaborative regeneration. The curious vignettes playfully invert hierarchies, revealing the merits of small-time memorialization. Through these defiantly unofficial grassroot performances, the Doll’s Head Trail both remembers and restores community ruins, demonstrating …

Advancing Social Sustainability In Operations And Supply Chain Management: A Multi-Theoretical Exploration Of Technology, Task Familiarity, And Sustainability Interactions, Satabdi Hazarika

Graduate Theses and Dissertations

Social sustainability in operations and supply chain management (OSCM) centers on generating economic value through practices that safeguard people, communities, and broader societal systems impacted by the supply chain. While the importance of such practices is increasingly recognized, firms face persistent challenges in embedding social sustainability into formal management systems. This dissertation tackles three such challenges, with a particular focus on safety in trucking—a vital yet underexamined aspect from the lens of social sustainability. Safety performance in this context is influenced by the complexities of using advanced safety technologies, the demanding and solitary nature of truck driving, and the temporal …

Stand-In Standing, Matthew I. Hall

Scholarly Works

When the interests of a state, or of the federal government, are at issue in a lawsuit, those interests are typically represented by the Executive branch. But not always: The Supreme Court has repeatedly held that states, and the federal government, may delegate their claims to non-governmental litigants in some circumstances. But the Court has never defined the exact boundaries of when stand-in standing is permitted. And states have recently begun to exploit this doctrinal uncertainty, by enacting laws that are arguably, and in some cases flagrantly, unconstitutional, but outsourcing the enforcement of those laws to private individuals. The avowed …

Evaluation Of Tracheal And Cecal Microbial Composition In Heat Stressed Broilers Supplemented With Phytogenic Additives, Andressa Silveira Stein

Graduate Theses and Dissertations

The rise in global temperatures has become a concern due to its significant impact on the agricultural sector, including poultry production. Heat stress caused by high temperatures directly affects animal welfare, health and productivity, leading to major losses in the poultry sector. In broilers, heat stress affects feed consumption, weight gain, mortality and may also lead to changes in the microbiome, which can increase the predisposition to disease and impact the overall performance of these animals. The aim of this thesis was to reproduce field conditions, simulating an increase in temperature, and to evaluate possible changes in the respiratory and …

Understanding Glufosinate Resistance In Palmer Amaranth And Examination Of Additives For Improved Weed Control, Pamela Carvalho-Moore

Graduate Theses and Dissertations

The aim of this dissertation was to: 1) provide an in-depth review about the potential use of natural and synthetic glutathione S-transferase (GST) inhibitors to enhance herbicidal activity or induce crop safety; 2) determine if the addition of metabolic inhibitors to glufosinate is an effective approach to enhance weed control; 3) investigate the mechanism conferring resistance to glufosinate in a highly-resistant Palmer amaranth accession; 4) characterize the genomic rearrangement involved in glutamine synthetase 2 amplification in a Palmer amaranth accession resistant to both glufosinate and glyphosate; 5) quantify the distribution of glufosinate resistance among Palmer amaranth accessions within a 15-km …