Digital Commons Network^™

Dissecting Microbial Communities With Single-Cell Transcriptome Analysis, Andrew W Pountain, Itai Yanai

Faculty, Staff and Student Publications

Revealing insights into the function of microbial communities requires moving beyond measuring bulk taxonomic composition to detecting interactions between subpopulations. Following the transformative impact of single-cell gene expression profiling techniques on numerous fields of human biology, recent years have seen increased application to microbes. We review progress in the development of these techniques and discuss challenges in applying them to microbial communities. We highlight applications for dissecting the microbiome in human health and disease that reveal functional heterogeneity within gut communities, antibiotic responses, and the dynamics of mobile genetic elements. As single-cell gene expression technologies continue to develop, they are …

Lewy Body Dementia Promotion By Air Pollutants, Xiaodi Zhang, Haiqing Liu, Xiao Wu, Longgang Jia, Kundlik Gadhave, Lena Wang, Kevin Zhang, Hanyu Li, Rong Chen, Ramhari Kumbhar, Ning Wang, Chantelle E Terrillion, Bong Gu Kang, Bin Bai, Minhan Park, Ma Cristine Faye Denna, Shu Zhang, Wenqiang Zheng, Denghui Ye, Xiaoli Rong, Liu Yang, Lili Niu, Han Seok Ko, Weiyi Peng, Lingtao Jin, Mingyao Ying, Liana S Rosenthal, David W Nauen, Alex Pantelyat, Mahima Kaur, Kezia Irene, Liuhua Shi, Rahel Feleke, Sonia García-Ruiz, Mina Ryten, Valina L Dawson, Francesca Dominici, Rodney J Weber, Xuan Zhang, Pengfei Liu, Ted M Dawson, Shizhong Han, Xiaobo Mao

Faculty, Staff and Student Publications

Evidence links air pollution to dementia, yet its role in Lewy body dementia (LBD) remains unclear. Here we showed in a cohort of 56.5 million individuals across the U.S. that PM2.5 exposure raises LBD risk. Mechanistically, we found PM2.5 exposure led to brain atrophy in wild-type mice, an effect not seen in α-synuclein (αSyn)-deficient mice. PM2.5 exposure generated a highly pathogenic αSyn strain, PM-PFF, with enhanced proteinase K-resistance and neurotoxicity, resembling αSyn LBD strains. PM2.5 samples from China, the U.S., and Europe consistently induced proteinase-resistant αSyn strains and in vivo pathology. Transcriptomic analyses revealed shared responses between PM2.5-exposed mice and …

Detection Of Cancers Three Years Prior To Diagnosis Using Plasma Cell-Free Dna, Yuxuan Wang, Corinne E Joshu, Samuel D Curtis, Christopher Douville, Vernon A Burk, Meng Ru, Maria Popoli, Janine Ptak, Lisa Dobbyn, Natalie Silliman, Josef Coresh, Eric Boerwinkle, Anna Prizment, Chetan Bettegowda, Kenneth W Kinzler, Nickolas Papadopoulos, Elizabeth A Platz, Bert Vogelstein

Faculty, Staff and Student Publications

To explore how early can cancers be detected prior to clinical signs or symptoms, we assessed prospectively collected serial plasma samples from the Atherosclerosis Risk in Communities (ARIC) study, including 26 participants diagnosed with cancer and 26 matched controls. At the index time point, eight of these 52 participants scored positively with a multicancer early detection (MCED) test. All eight participants were diagnosed with cancer within 4 months after blood collection. In six of these 8 participants, we were able to assess an earlier plasma sample collected 3.1 to 3.5 years prior to clinical diagnosis. In four of these six …

A Proven Template For Providing Streamlined, Scalable, Cost-Effective Clinical Research Opportunities In Osteopathic Medical Schools, Jacey N. Greek, Andrew Greek, Mari Hopper, Robert Arnce

Student Publications

Context: In an era in which clinical research plays a crucial role in advancing medical knowledge and contributing to the resume of medical students attempting to match into a residency, the creation of sustainable and effective research opportunities within medical education is paramount. Colleges of Osteopathic Medicine (COMs) face unique challenges in creating these opportunities in a scalable and cost-efficient manner. Without these opportunities, osteopathic medical students may find themselves at a disadvantage compared to their allopathic counterparts in residency placements and academic career paths.

Objectives: We have created a template for providing perpetual, streamlined, scalable, cost-effective clinical research at …

Tet2-Mutant Myeloid Cells Mitigate Alzheimer’S Disease Progression Via Cns Infiltration And Enhanced Phagocytosis In Mice, Katie A Matatall, Trisha K Wathan, Minh Nguyen, Hu Chen, Alexandra Mcdonald, Guantong Qi, Julia A Belk, Marcus A Florez, Duy T Le, Temitope Olarinde, Caitlyn Vlasschaert, Marco M Buttigieg, Chih-Wei Fan, Saul Carcamo, Ruoqiong Cao, Daniel E Kennedy, Arushana A Maknojia, Apoorva Thatavarty, Josaura V Fernandez Sanchez, Hind Bouzid, Surabi Veeraragavan, Susan Crocker, Margaret A Goodell, Antony Rodriguez, Siddhartha Jaiswal, Michael J Rauh, Eirini P Papapetrou, Samuele G Marro, Katherine Y King

Faculty, Staff and Students Publications

No abstract provided.

Influences On Suicidality And Suicide-Prevention Needs For The Autistic Community: Qualitative Insights From Multiple Perspectives, Anne V. Kirby, Kristina Feldman, Wilhelm Clark, Amber N. Darlington, Alissa Atisme, Bobbi Duncan-Ishcomer, Rachel Kripke-Ludwig, Andrea Joyce, Whitney Lee, K. Rodriguez, Zack Siddeek, Kavitha Murthi, Brooks Keeshan, Hilary Coon, Christina Nicolaidis

School of Social Work Faculty Publications and Presentations

Autistic individuals are disproportionately likely to experience suicidal thoughts, feelings, and actions. Addressing suicidality is also a high priority of autistic community members. The goal of this study was to understand broad influences on suicidality and suicide-prevention needs for the autistic community. Using a community-based participatory research approach, we conducted a reflective thematic analysis of qualitative interviews with 16 autistic adults, 8 family members, and 14 mental health providers. Themes summarizing influences on suicidality and suicide-prevention needs centered on three broad thematic concepts: (1) Pervasive negative societal attitudes and social experiences have a lasting impact on autistic people's feelings of …

The Causal Pivot: A Structural Approach To Genetic Heterogeneity And Variant Discovery In Complex Diseases, Chad A Shaw, C J Williams, Taotao Tan, Daniel Illera, Nicholas Di, Joshua M Shulman, John W Belmont

Center on Aging Staff Publications

We present the Causal Pivot (CP) as a structural causal model (SCM) for analyzing genetic heterogeneity in complex diseases. The CP leverages an established causal factor or factors to detect the contribution of additional suspected causes. Specifically, polygenic risk scores (PRSs) serve as known causes, while rare variants (RVs) or RV ensembles are evaluated as candidate causes. The CP incorporates outcome-induced association by conditioning on disease status. We derive a conditional maximum-likelihood procedure for binary and quantitative traits and develop the Causal Pivot likelihood ratio test (CP-LRT) to detect causal signals. Through simulations, we demonstrate the CP-LRT’s robust power and …

Dampak Jumlah Kredit Yang Dimiliki Rumah Tangga Terhadap Kekerasan Dalam Rumah Tangga (Kdrt) Pada Anak Di Indonesia, Anjar Maulitfiani, Dwini Handayani

Jurnal Kebijakan Ekonomi

This study examines the impact of intensity of household debt on domestic violence (DV) towards children in Indonesia. There is a positive relationship between the amount of household debt and the likelihood of domestic violence towards children based on literature review. This research uses a quantitative method with multinomial logistic regression analysis. The results of this study indicate that households with more than one household debt are correlated with an increased likelihood of both psychological and physical domestic violence towards children compared to the likelihood of no domestic violence, both before and after controlling variables added.

A Tale Of Two Schools: A Comparative Case Study Demonstrating Organizational Pathways To Educator Collaborations, Michael W. Valenti Ph.D., Duhita Mahatmya, Elizabeth Levine-Brown, Karen Celedonia, Tracy Sweet

Mid-Western Educational Researcher

Effective staff collaboration in schools maximizes educators’ collective capacity, improves educator and student outcomes, and facilitates school-wide improvement efforts. Yet, many school team members struggle to collaborate effectively. Previous studies have demonstrated individual and school-level factors that influence school-based collaborations. This study expands former research by comparing the varying administrative and environmental tools employed by two schools to shape relational networks and foster interpersonal capital. Specifically, this case study explores how school-level factors shape the development of school social networks and staff collaborative behavior. We use comparative case study analysis to explore how differences in individual-level and system-level factors influence …

Exploring Health Care Access Among Lesbian, Gay, Bisexual, And Transgender (Lgbt) Populations, Austin Nation, Phyllis Raynor, Frieda H. Outlaw, Carlo Hojilla

International Nursing Research Congress (INRC)

PURPOSE: The purpose of this project is to explore the current experiences and needs of the lesbian, gay, bisexual, and transgender (LGBT) population, including health care and mental health utilization, patterns, locations, adequacy of LGBT-friendly health and mental health care providers. There are an estimated 90,000 LGBT individuals over the age of 14 in Orange County. LGBT populations are unique and are known to have significant health disparities, particularly if they are from racial or ethnic groups or have a disability. LGBT individuals are known to experience adverse situations when accessing health care and mental health services, including issues with …

Authentic Leadership In Nursing: Global Impact And Insights From An Integrative Review, Robie Victoria Hughes, Jihane Frangieh, Julia Cardoso Cardoso

International Nursing Research Congress (INRC)

The purpose of the integrative review is to analyze the current literature to determine authentic leadership impact on nursing outcomes world-wide. Authentic leadership theory, studied extensively in recent years, is a critical component of effective leadership in healthcare linked to improved patient outcomes, increased healthy work environments, and decreased burnout rates among nurses. An integrative literature search on “authentic leadership”, “outcomes” and “nursing” was conducted in five electronic databases: CINAHL, EMBASE, Web of Science, Scopus, and MEDLINE via the PubMed portal, from February 2023 to April 2023. Twenty-five quantitative studies, conducted in 10 countries, met the inclusion criteria. The authors …

Faculty Facilitated New Graduate Nurse Mentoring Program, Tina Michelle Dorau

International Nursing Research Congress (INRC)

Background: There has been a lack of consistent high-quality residency and orientation programs for new graduate registered nurses (NGRNs) throughout the United States including Central Wisconsin.

Purpose: The practice gap has existed for many years and was recognized in the 1970’s when Kramer (1974) coined the phrase “reality shock”. The purpose of the mentoring program was to bridge the gap between the academic setting and the clinical setting for the NGRN in their first 90-days of practice.

Methods: The mentoring program was presented to prelicensure students during their final semester in nursing school. The mentoring program began when the prelicensure …

A Validation Experiment: Utilizing Ultraviolet Light To Disinfect High Use Nursing Equipment, Gordon West

International Nursing Research Congress (INRC)

Background: Healthcare staff continue to utilize equipment that can travel from patient room to patient room without disinfection or cleaning between use. Additionally, nursing and housekeeping staff may not always communicate clearly regarding responsibilities for cleaning some of these items. The purpose of this study was to identify if a portable UV-C tent utilized with a UV-C device (Xenex® LightStrike™ Robot) can effectively disinfect high use equipment used within inpatient nursing units across a large military medical treatment facility.

Method: Healthcare equipment consisting of commodes, toilet seat risers, wheelchairs, vital sign machines, workstations on wheels, and bassinets were pre swabbed …

“Overpriced & Over Dosed”: Thematic Analysis Of Perceived Root Causes Of Us Maternal Mortality Rate, Emily Richardson, Rebecca Mccann

International Nursing Research Congress (INRC)

Maternal mortality in the United States (US) is a problem of growing concern. In 2021 maternal mortality accounted for 32.9 deaths per 100,000 with non-Hispanic Black clients having a mortality rate of 2.6 times higher than non-Hispanic Whites. Of utmost concern, is the determination that over 80% of pregnancy related deaths were preventable. With the growing press around this topic, the authors sought to analyze the public’s perceived root causes for the increase in poor maternal outcomes. As maternal/ child experts, the authors know that client perception may not always be medically reliable; therefore, this study aims to gain understanding …

Effects Of Chatbot On Surgical Patients: A Systematic Review, Chung Man Ho, Mei Ping Priscilla Choi

International Nursing Research Congress (INRC)

Aim: To evaluate the effectiveness of chatbots in enhancing patient knowledge, alleviating psychological distress, and improving compliance compared to traditional methods among surgical patients.

Design: A systematic review.

Methods: Randomised controlled trials and quasi-experimental studies involving patients undergoing surgeries under general anaesthesia were reviewed. The risk of bias was assessed using the Cochrane Risk of Bias Tool for randomised controlled trials and the Risk of Bias in Non-randomised Studies of Interventions tool for non-randomised controlled trials.

Results: Nine studies with 1476 patients were included in this review. Conversational agents significantly improved perioperative knowledge, psychological distress and compliance with preoperative instructions, …

The Relationship Between The Hesi Integrated Exit Exam & Next Generation Nclex-Rn: Updated, Mamta Shah, Peter Granville, Ryan S. Baker, Michelle Bussard

International Nursing Research Congress (INRC)

Purpose
The purpose of this study was to determine the extent to which the HESI Integrated Exit Exams (E2) can predict nursing students’ first-time pass rates on the Next Generation NCLEX-RN (NGN-RN), expanding on findings reported by Shah et al (2024). Programs typically set a minimum score threshold of 850 or 900 on the E2 to consider students ready for the NCLEX (Olsen et al., 2022). We examined, "If students achieve a benchmark score on the E2, do they pass the NGN-RN on their first attempt?" Previous research has also examined the role of E2 policies and their association with …

Developing A Machine Learning Method To Identify Racial Disparities In End-Stage Kidney Disease, Brandon M. Varilek, Semhar Michael, Hossein Moradi Rekabdarkolaee, Patti J. Brooks, Surachat Ngorsuraches

International Nursing Research Congress (INRC)

End-stage kidney disease (ESKD) disproportionately affects Hispanic and American Indian (AI) persons with prevalence rates more than double of White persons. Furthermore, all-cause mortality is significantly higher for Hispanic and AI. The increased prevalence and mortality rates can be attributed to the higher level of health disparities caused by social determinants of health (SDOH). We are developing machine learning and computational models based on patient-level ESKD data at zip code or county level paired with SDOH data to predict the risk of mortality among Hispanic and AI persons with ESKD in South Dakota who have varying socio-demographic characteristics. The primary …

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Indian Journal of Law and Technology

No abstract provided.

Copyright Information

Journal of Science Education for Students with Disabilities

Publication rights to works is granted to Journal of Science Education for Students with Disabilities, however, full copyright for works published in this journal is retained by the author(s). The author(s) may post their works online in an institutional repository, on their University departmental website, or on their own personal websites.

Blood Glucose Concentration In Highly Prolific Sows Before Farrowing: Its Relationship With Parity And Litter Size, Preechaphon Taechamaeteekul, Silvia Comencini, Fabio De Rensis, Roberta Saleri, Padet Tummaruk

The Thai Journal of Veterinary Medicine

Farrowing is an energy-demanding period for prolific sows, with blood glucose levels serving as key indicators affecting farrowing outcomes and piglet survival. This study aimed to evaluate blood glucose levels in prolific sows prior to farrowing, assess the prevalence of hypoglycemia in late gestation, and investigate the relationship between blood glucose levels, parity, and litter size under tropical conditions. A total of 67 Danish Landrace × Yorkshire sows were grouped based on litter size (6–14, 15–17, or ≥18 piglets) and parity (2–4 and 5–6). To determine glucose levels, blood samples were collected at 115.8 ± 1.6 days of gestation, at …

The Green Approach Of Arabic Gum-Based Adsorbent In Wastewater Treatment, Atheel H. Alwash

AUIQ Technical Engineering Science

The natural polysaccharide Arabic gum is a multifunctional, sustainable material used widely in wastewater treatment technology. Its active functional groups such as hydroxyl, carboxyl, and amino groups facilitate the efficient removal of heavy metals, dyes, pesticides, pharmaceuticals, and persistent organic pollutants. The high surface area and active functional groups facilitate its modification to form various structures such as hydrogels, nanocomposites, or biochar integrated into hybrid adsorption–photocatalysis systems. This review highlights the most familiar forms of Arabic gum in wastewater treatment technology, such as hydrogels, hydrogels nanocomposite, stabilizing agents, coating agents, and bio-activated carbon derived from Arabic gum using different preparation …

Memf-Net: A Mega-Ensemble Of Multi-Feature Cnns For Classification Of Breast Histopathological Images, Alaa Hussein Abdulaal, Ali H. Abdulwahhab, Aqeel Majeed Breesam, Zahra Hasan Oleiwi, Riyam Ali Yassin, Morteza Valizadeh, Saja Nafea Mohsin

Iraqi Journal for Computer Science and Mathematics

Pathological anatomical images play a pivotal role in diagnosing diseases, notably breast cancer, which affects women globally. These images, obtained through biopsies or post-mortem examinations, are preserved to maintain their structural integrity. Software tools, like computer-aided diagnosis, aid doctors in early detection and treatment planning, contributing to reduced mortality rates. In this context, convolutional neural networks (CNNs) have emerged as valuable tools for diagnosing benign and malignant breast cancers. This paper introduces a Mega Ensemble Net method, leveraging multi-scale combination features on the breast histopathology dataset. Three fine-tuned deep learning models, namely ResNet-18, ResNet-34, and ResNet-50, are integrated into this …

Retracted: Capsule Network Model For Detecting Spoofing Attack In The Internet Of Medical Things (Iomt), Mohammad A. Alsharaiah, Mohammed Amin Almaiah, Mansour Obeidat, Rami Shehab

Iraqi Journal for Computer Science and Mathematics

The Internet of Medical Things (IoMT) has transformed healthcare delivery through real-time monitoring and data exchange. However, this integration of smart medical devices has also introduced critical cybersecurity threats, particularly spoofing attacks, which can compromise patient safety and system reliability. Conventional Intrusion Detection Systems (IDS) often fail to address IoMT-specific challenges such as class imbalance, computational constraints, and the need for real-time adaptability. This study proposes a Capsule Network (CapsNet)-based IDS that leverages spatial dependency modeling and hierarchical feature relationships to detect spoofing attacks in IoMT environments. Using the CICIoMT2024 dataset, we implemented a binary classification framework where spoofing instances …

Distinguished Service Awards To Be Presented Sept. 26, Maurer School Of Law - Indiana University

Keep Up With the Latest News from the Law School (blog)

Three alumni of the Indiana University Maurer School of Law will be honored with Distinguished Service Awards later this month, in concert with the Law School’s fall Alumni Board meeting.

Matthew Metz ’19, Delanie Pope ’93, and Hannah E. Wilson ’22 will each receive the award, which was established in 1997 to recognize graduates of Law School who have distinguished themselves in service to their communities and the school in ways far exceeding traditional business, professional, and civic duties.

Faculty Newsletter Fall 2025, University Of Missouri-St. Louis Libraries

Library Publications

No abstract provided.

Contested Development: China’S Influence, Authoritarian Agency, And Ngo Resistance In Uganda, Saara E. Leppanen

Global Governance Theses and Dissertations

In 2021, the Ugandan government suspended the operations of 54 non-governmental organizations (NGOs), citing a range of administrative and legal justifications. This crackdown reflects a broader pattern emerging across the African continent, where over the past twenty years, more than twenty-four states have introduced restrictions on NGOs, particularly those engaged in human rights advocacy and governance. At the same time, the continent has witnessed a marked increase in Chinese investment, most notably through Beijing’s Belt and Road Initiative (BRI), launched in 2013 as a global infrastructure and development project. While scholarship on the BRI has increased, limited attention has been …

Fs Agenda 2025-09-03, Northern Illinois University

Faculty Senate Archives

No abstract provided.

The Strategic Analysis Of Jpmorgan Chase, Terryce Boseman

MBA Student Scholarship

No abstract provided.

Cognition, White Matter Hyperintensities And Suicide Risk In Late-Life Depression Patients: An Exploratory Study, Martha Sajatovic

Faculty Scholarship

Objective: Suicide among older adults represents a major public health concern and is closely associated with late-life depression (LLD). White matter hyperintensities (WMHs), frequently observed in the aging population, have been linked to both LLD and cognitive impairment. However, the role of WMH burden and cognitive dysfunction in older adults with LLD who have recently attempted suicide remains unclear. This study aims to investigate differences in WMH burden and cognitive performance across three groups: LLD patients with a recent suicide attempt (recent suicide attempt group, RSA), non-suicidal LLD patients (non-suicidal group, NS), and healthy older adults (healthy comparison group, HC). …

Dietary And Consumer Behaviors In Individuals Currently Using Substances: A Cross-Sectional Study Based On Nhanes (2013 - 2018), A Sarah Cohen, Marylou Cardenas-Turanzas, Audrey Lopez, Tiffany Champagne-Langabeer

Faculty, Staff and Student Publications

Background: Substance use disorders (SUD) are associated with metabolic dysregulation and nutritional deficiencies. Studies show that incorporating nutrition interventions into treatment may improve physical and psychological health. This study sought to explore dietary and consumer behavior in individuals currently using substances.

Methods: Data from the 2013 - 2018 National Health and Nutrition Examination Survey were used for this cross-sectional study. Individuals 18 - 69 who were currently using marijuana, cocaine, heroin, methamphetamines, or injected unprescribed drugs were compared with individuals not using substances. Dietary and consumer behavior, including alcohol consumption was assessed. Analyses were performed using Stata I/C version 15. …