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Counterclaim Preclusion: Foreseeability, Finality, And Fairness, Leslie C. Behaunek Oct 2025

Counterclaim Preclusion: Foreseeability, Finality, And Fairness, Leslie C. Behaunek

Dickinson Law Review (2017-Present)

Foreseeability, finality, and fairness are some of the primary interests to balance when analyzing the appropriate scope of preclusion doctrines. Scholars like Richard Freer, Alan Trammell, Lindsey Simon, and others have recently written about defense preclusion, fictional consent to a court’s jurisdiction, and the scope of claim preclusion. Existing scholarship has long recognized the confusion experienced by courts and litigants in cases involving preclusion doctrines. These recent discussions, however, do not address the continued problem that exists with the current stateby-state patchwork of counterclaim preclusion law. After a court enters judgment against a defendant in the plaintiff’s chosen forum (F1), …


Sovereign Solutions: Reclaiming Reproductive Autonomy In Oklahoma Indian Country After Dobbs, Morgan Sandler Oct 2025

Sovereign Solutions: Reclaiming Reproductive Autonomy In Oklahoma Indian Country After Dobbs, Morgan Sandler

Dickinson Law Review (2017-Present)

In the United States, Native American women face disproportionately high rates of sexual violence and adverse maternal health outcomes. In addition to these ongoing challenges, they continue to face significant barriers to reproductive healthcare access. Oklahoma’s near-total abortion ban—without exceptions for rape or incest—exacerbates these negative trends, particularly for Native women and the Two-Spirit community. Following the Supreme Court’s decision in McGirt v. Oklahoma, approximately 42 percent of Oklahoma’s land area is recognized as Indian Country. This Comment explores how Oklahoma’s abortion ban disproportionately impacts Native women due to systemic inequities stemming from the federal government’s long history of …


A Call For Canceling Compassionate Release And Restoring Federal Parole, Honorable Chief Judge C.J. Williams Oct 2025

A Call For Canceling Compassionate Release And Restoring Federal Parole, Honorable Chief Judge C.J. Williams

Washington and Lee Law Review

The current federal sentencing scheme is a patchwork quilt of provisions that grant judges virtually unfettered and unreviewable discretion imposing sentences on the front-end and in granting compassionate release on the back end. It was not designed in the beginning to be this way. The advisory-only sentencing guidelines scheme we have now resulted from the Supreme Court’s finding that mandatory guidelines violated the Constitution. The recent sentencing reform movement—of which compassionate release is a significant part—has sought to find ways of ameliorating what is seen as the draconian result of the war on drugs. The question is whether granting Article …


Equity Partners Or Equity Predators? A Call For Federal Regulations To Safeguard Against Abusive Home Equity Sharing Agreements, Lindsay Lankau Oct 2025

Equity Partners Or Equity Predators? A Call For Federal Regulations To Safeguard Against Abusive Home Equity Sharing Agreements, Lindsay Lankau

Washington and Lee Law Review

Home equity sharing agreements are on the rise throughout the country. In a home equity sharing agreement, homeowners are given a lump sum of cash, upfront, in exchange for a portion of their home’s future value. Agreements are structured however the investment company prefers and are not subject to any state usury caps, mortgage loans, or federal lending laws. The investment companies believe that their product is exempt from all of these requirements, despite the high risk that home equity sharing poses to consumers. In reality, home equity sharing agreements are dangerous, unregulated mortgage loans, which are being utilized by …


Women, Life, And Freedom: The Changing Landscape Of Iranian Women’S Movements Before And After The Islamic Revolution, Emily Snyder Oct 2025

Women, Life, And Freedom: The Changing Landscape Of Iranian Women’S Movements Before And After The Islamic Revolution, Emily Snyder

Araneum: Richmond Journal of American & Global Affairs

Iranian women’s movements, both pre- and post-Islamic Revolution, have continually adapted to the repressive tactics of those in power to advocate for women’s rights in an authoritarian environment. With the introduction of social media, Iranian feminists have been able to counter political suppression and successfully organize against the regime. In this paper, I analyze how Iranian women’s movements have changed before and after the Islamic Revolution, and how social media has allowed modern women’s movements to succeed amidst state surveillance and political violence at the hands of the regime. I determine that social media has been a crucial factor in …


Nepal’S Lost Generation: Emigration And Fertility In Asia, Kalina Kulig Oct 2025

Nepal’S Lost Generation: Emigration And Fertility In Asia, Kalina Kulig

Araneum: Richmond Journal of American & Global Affairs

This paper examines the causes and impacts of Nepal’s “lost generation,” a group of young people

leaving the country in high numbers. I begin by analyzing the causes of emigration, dividing factors into push and pull, and identifying the most important reasons young Nepalis are leaving the country. Next, I explore the impacts of emigration on Nepali society, explaining why the trend of young people working abroad makes Nepal an artificially aged nation. Here, I suggest that rapid population declines can erode the social fabrics and economies of smaller, less developed countries. Finally, I argue that political scientists interested in …


In Defense Of The Care Economy, Emily Daniel Oct 2025

In Defense Of The Care Economy, Emily Daniel

Araneum: Richmond Journal of American & Global Affairs

Women are burdened with caregiving, yet their contributions are frequently undervalued and undercompensated. During the nineteenth century, women worldwide gained the right to vote, access to education, marital freedom, and the right to join the workforce. Yet today, they contribute significantly to unpaid or low-paying care work, tending to domestic responsibilities while participating in the labor force. These roles are motivated by moral or altruistic values rather than financial compensation and provide for needs in childhood, old age, and sickness. With women doing an average of 2.5 times more unpaid domestic work than men, they are at the heart of …


To Praise “Xi Dada”: Analyzing The Personality Cult Of Xi Jinping, Olivia Gondek Oct 2025

To Praise “Xi Dada”: Analyzing The Personality Cult Of Xi Jinping, Olivia Gondek

Araneum: Richmond Journal of American & Global Affairs

In 2018, just three days before the National People’s Congress abolished presidential term limits, Chinese citizens piled into sold-out theaters to watch Amazing China. This 90-minute documentary about China’s rejuvenation under President Xi Jinping has since become the country’s highest-earning documentary. However, reports failed to acknowledge that state-sponsored companies were the sole producers, reviewers, and marketers of the film. Moreover, Amazing China premiered during a time when accusations of Xi governing through a personality cult—a legitimacy technique based on a sole figure’s unique charisma and God-like qualities—“were intensifying rapidly.” Since taking office in March 2013, Xi Jinping’s presidency has been …


Foundations In Bilingual Education, Eln123, Fall 2025: Syllabus, Bede Mccormack Oct 2025

Foundations In Bilingual Education, Eln123, Fall 2025: Syllabus, Bede Mccormack

Open Educational Resources

Foundations of Bilingual Education (ELN123) is a writing intensive course that requires students to be engaged in several high and low stakes writing activities throughout the semester. This requirement will be fulfilled through several informal written assignments and a formal written assignment. Course topics include cultural, psychological, socioeconomic, linguistic, cognitive and curricular factors that affect the academic achievement of emergent bilingual students. It introduces the philosophical, legal, and sociological aspects of bilingual education, and prepares reflective educators through the use of a teacher education ePortfolio. It also satisfies the Urban Studies requirement at LaGuardia. This course is equivalent to a …


A Holistic Look At Swiss Primary Education In The 1870s-80s, As Reflected In Johanna Spyri’S Heidi, Hazel Handy Oct 2025

A Holistic Look At Swiss Primary Education In The 1870s-80s, As Reflected In Johanna Spyri’S Heidi, Hazel Handy

Mountains and Modernity

Education is a cornerstone theme in Johanna Spyri’s treasured novel Heidi, which tells the story of a young girl living in the Swiss Alps with her grandfather. Heidi has many triumphs throughout her youth, but these are not without hardship with regard to educational attainment. This paper examines how the educational experiences described in Heidi fits into its historical context, having been set in the 1870s-80s in Switzerland and Germany. Legal precedents, labor relations, and a mountainous environment set the stage for educational access and success for both Heidi and her friend Peter. Heidi depicts how the emotional experiences of …


Reflections Of The Era: Representations Of Turbulent Peace And Looming Conflict In Choucas And The Accident, Shenandoah Waugh Oct 2025

Reflections Of The Era: Representations Of Turbulent Peace And Looming Conflict In Choucas And The Accident, Shenandoah Waugh

Mountains and Modernity

This paper examines the relationship between society and the environment through the lens of two novels: Choucas by Zofia Nałkowska and The Accident by Mihail Sebastian. Choucas was written in the interwar period and focuses on international cooperation in the setting of a sanatorium and resort in the Swiss Alps. The Accident was written in the early years of World War II and takes place in Bucharest and the Carpathian mountains near Brașov, Romania. Both novels utilize the mountainous settings to reflect on the tensions of their respective eras. Choucas relates the mountains and valleys to the turbulent peace of …


Characterization Of Pigeonpea As An Alternate Summer Forage Crop In Virginia, Satya S. S. Narina, Glenn Chappell Iii, Harbans L. Bhardwaj Oct 2025

Characterization Of Pigeonpea As An Alternate Summer Forage Crop In Virginia, Satya S. S. Narina, Glenn Chappell Iii, Harbans L. Bhardwaj

Virginia Journal of Science

Pigeonpea (Cajanus cajan L.), a major multifunctional food legume crop valued globally, contributes to food security by supplying protein-rich grain for human consumption and provides nutrient-rich biomass for livestock feeding across diverse production systems. However, little is known about its forage potential in the mid-Atlantic region of the United States. In 2009 and 2010, four cultivars (GA-1, GA-2, W-1, and W-3) were evaluated in a split-plot design with three intra-row plant populations (2, 4, or 6 plants per 0.3 m row) and three planting dates (May, June, and July). Forage yield, crude protein, minerals, and other nutritional traits were …


Hirzel, Freiheit, Und Die Berge: Wie Sich Johanna Spyris Leben In Heidi Widerspiegelt, Luciana Zaiet Oct 2025

Hirzel, Freiheit, Und Die Berge: Wie Sich Johanna Spyris Leben In Heidi Widerspiegelt, Luciana Zaiet

Mountains and Modernity

Heidi is a Swiss children’s novel that has achieved widespread popularity since its publication in 1880, yet little is known about the author, Johanna Spyri. This text compares available biographical information on Spyri to the world of Heidi. Parallels such as the presence of rural social structures, children’s freedoms, and the view of mountains as a sanctuary from the ills of urbanity and its social restrictions, reveal how elements of Spyri’s life were adapted through the narrative process to create a standalone, idyllic narrative of childhood in the Alps that has grown to be globally beloved.


Strategic Branding: The Critical Role Of Brand Strategy For Successful Branding Initiatives, Sara Virginia Abell Oct 2025

Strategic Branding: The Critical Role Of Brand Strategy For Successful Branding Initiatives, Sara Virginia Abell

Senior Honors Theses

In the increasingly saturated world of branding, the ability to rise above the noise and establish meaningful connections with an audience is essential. This thesis explores the relationship between brand strategy development and successful branding outcomes. An initial review of relevant literature is conducted, focusing on the importance and creation of strategy. Further consideration is given to the unique challenges associated with rebranding efforts. The practical impact of brand and rebrand strategies is underscored through case studies across varying contexts. Following this, the implementation of strategy is discussed, with an emphasis on the role of design elements and principles in …


Toward The Human Right To Water For Vulnerable Communities: The Effectiveness Of Stakeholder Processes To Control Regional Shallow Groundwater Contamination By Nitrates, Iris Stewart, John Dialesandro, Samantha Lei, Lilah Foster Oct 2025

Toward The Human Right To Water For Vulnerable Communities: The Effectiveness Of Stakeholder Processes To Control Regional Shallow Groundwater Contamination By Nitrates, Iris Stewart, John Dialesandro, Samantha Lei, Lilah Foster

Environmental Studies and Sciences

Nitrate contamination in shallow drinking water wells is an urgent and persistent concern for agricultural regions and disadvantaged communities worldwide. As viable options for the large-scale removal of nitrates from groundwater remain elusive, greater emphasis has been placed on stakeholder-based integrative approaches, yet few have been developed, and fewer evaluated for their effectiveness. The Central Valley in California is one of the most important intensive agricultural regions globally, where such a stakeholder-based process (CV-SALTS) has been initiated, and which is poised to serve as a model for controlling nitrate contamination elsewhere. Based on the Groundwater Ambient Monitoring and Assessment Program …


Fundamentals Of A Sustainability Profile Of Students Based On Quantitative Community Building Analyses, Cormac Mcmahon, Julie Dunne, Catherine Barry Ryan, María J. Cantalejo, Carlos Vilches, Isabel Navarlaz, Maite Aldaya, Annapia Ferrara, Sabrina Tomasi, Chiara Mignani, Alessio Cavicchi, Sami Sami Ghnimi, Sghaier Chriki, Michael Murkovic, Barbara Siegmund, Lena Pfeiffer Oct 2025

Fundamentals Of A Sustainability Profile Of Students Based On Quantitative Community Building Analyses, Cormac Mcmahon, Julie Dunne, Catherine Barry Ryan, María J. Cantalejo, Carlos Vilches, Isabel Navarlaz, Maite Aldaya, Annapia Ferrara, Sabrina Tomasi, Chiara Mignani, Alessio Cavicchi, Sami Sami Ghnimi, Sghaier Chriki, Michael Murkovic, Barbara Siegmund, Lena Pfeiffer

Research Outputs: 2025-Present

In the context of a growing awareness of environmental challenges and the importance of sustainability values, practices, and choices, this article presents the key findings of the European co-funded NEMOS research project (A New Educational Model of Sustainability Competences through Service-learning) focused on defining the sustainability profile and competencies of students through service-learning in Higher Education. A community-building bottom-up methodology was innovatively applied to identify the competencies needed to define a sustainability profile of students in food-related degrees of five European Higher Education Institutions.The research findings highlight the need for a holistic understanding of students´sustainability, including economic, social, and environmental …


Case Global: A Winning Tradition, Case Western Reserve University School Of Law, The Frederick K. Cox International Law Center Oct 2025

Case Global: A Winning Tradition, Case Western Reserve University School Of Law, The Frederick K. Cox International Law Center

Case Global Newsletter

Volume 17, No. 1 (2025)

  • CWRU once again ranked among the best in 2025 PreLaw magazine and US News & World Report rankings of International Law Program...
  • Case Western Journal of International Law Tackles the Need to Update the Geneva Conventions
  • Building on a Winning Tradition
  • CWRU Launches New International Development Law Lab
  • CWRU Establishes Spring Break in the Hague Program
  • Professor Michael Scharf leads Team to Prepare Ukrainian Judges and Prosecutors to Try Environmental War Crimes
  • Professor Rapp teaches Comparative Law to Saudi Administrative Judges in Riyadh
  • Yemen Accountability Project publishes two new White Papers
  • Immigration Clinic Builds Momentum …


Small And Ugly Oer: Simple Strategies To Ease Faculty Into Open Education, Nancy A. Henke Oct 2025

Small And Ugly Oer: Simple Strategies To Ease Faculty Into Open Education, Nancy A. Henke

About OER

Open education advocates know the benefits of OER, but faculty newcomers may feel that adopting OER requires a complete overhaul of a course or that materials must be professionally designed to be effective. Inspired by James M. Lang’s Small Teaching, the concept of Small OER reframes OER adoption as a series of small, intentional steps—such as replacing a single textbook chapter or reading with an open alternative—rather than an all-or-nothing shift. Pairing this with the concept of ugly OER—simple, effective, and easily created resources like Google Docs or instructor-made PDFs—reduces barriers and helps faculty understand that OER don’t need to …


The Day Disco Died, Pearl Johnson Oct 2025

The Day Disco Died, Pearl Johnson

Gateway Reader- Individual Papers

  • The Problem: The researcher addresses how Disco Demolition Night, while appearing to be an innocuous expression of changing musical tastes, reflected deeper societal backlashes against marginalized communities—including Black, Latin, and LGBTQ populations—who pioneered and found freedom within the disco genre during a period of civil unrest.

  • The Method: The researcher analyzes historical event accounts, photographs, and media reports from the July 12, 1979 event at Comiskey Stadium, incorporating cultural commentary from music critics, social historians, and firsthand testimonies of attendees and staff.

  • Quantitative Finding: The Saturday Night Fever soundtrack is the highest-selling disco album of all time at 40 million …


(Si15-084) Application Of Differentiation Matrices Corresponding To Scaling And Wavelet Functions To Integral Equations, Viresh Kumar, Rakesh Kumar Oct 2025

(Si15-084) Application Of Differentiation Matrices Corresponding To Scaling And Wavelet Functions To Integral Equations, Viresh Kumar, Rakesh Kumar

Applications and Applied Mathematics: An International Journal (AAM)

In the present paper, we have studied the technique by which a differentiation matrix corresponding to scaling and wavelet function is helpful in representing an integral equation in discrete form. In this technique, only finite times continuously differentiable scaling and wavelet functions were used for the differentiation matrix. This method explores the applications of compactly supported wavelets in discretization of Fredholm integral equation and provides us with a bridge for the solution of integral equations via compactly supported finitely differentiable wavelets.


(Si15-107) Mathematical Modeling Of Cancer Dynamics Stability Analysis Of Post Therapy Protection, Rajendran Swetha, Tharmalingam Gunasekar, Kamalendra Kumar, Krishnasamy Sakthivel Oct 2025

(Si15-107) Mathematical Modeling Of Cancer Dynamics Stability Analysis Of Post Therapy Protection, Rajendran Swetha, Tharmalingam Gunasekar, Kamalendra Kumar, Krishnasamy Sakthivel

Applications and Applied Mathematics: An International Journal (AAM)

The study of PSITPS mathematical model is developed to analyze cancer dynamics, focusing on post-therapy protection. The model’s solution is rigorously examined for boundedness and positivity of solutions. Equilibrium points are identified, and numerical methods are employed to study stability. Simulations using accurate cancer data demonstrate the effectiveness of post-treatment protection in controlling cancer spread and minimizing recurrence. Stability analysis confirms the model’s predictive capability, offering valuable insights into long-term patient outcomes. The results highlight the importance of continuous post-treatment care in improving survival rates and reducing disease prevalence. This study provides a framework for optimizing cancer treatment strategies by …


Noise Law, Joshua Ulan Galperin Oct 2025

Noise Law, Joshua Ulan Galperin

Elisabeth Haub School of Law Faculty Publications

The rumble of traffic, the drone of air conditioners, the blast of construction equipment. These are the mundane sources of noise pollution that we all experience but rarely think about. Or, if we do think about noise pollution, we don't think of it as a central piece of federal environmental law. This Article, however, demonstrates that noise law is, or was, central to American environmental law, and it offers insights into how environmental protection and administrative governance work today.

In the 1970s, during the height of environmental activism and policymaking, lawmakers recognized noise as a serious pollutant alongside issues we …


Gender And Tax Scholarship As Critical Method, Bridget J. Crawford Oct 2025

Gender And Tax Scholarship As Critical Method, Bridget J. Crawford

Elisabeth Haub School of Law Faculty Publications

Part I of this Essay offers an overview of the legal scholarship that laid the intellectual foundation for the field of gender and tax scholarship. Part II briefly recaps the organization of the symposium and the work presented. The collective work arising from the symposium reflects both the breadth and complexity of contemporary thinking on gender and taxation. In many cases, the symposium essays push the boundaries of the field in new and generative directions. Part III then turns toward the future, identifying areas of inquiry that remain underexplored, with an eye toward paths for continued research. This Essay closes …


St-03 - Kansas 2025-10-01, Maribeth Shafer Oct 2025

St-03 - Kansas 2025-10-01, Maribeth Shafer

State Representatives

No abstract provided.


Concurrent Local Therapy Extends Clinical Benefit Of Tebentafusp In Metastatic Uveal Melanoma Patients, Tristan L. Lim, Kamaneh Montazeri, Eric Wehrenberg-Klee, Antoine Desilets, Rino S. Seedor, Marlana Orloff, Takami Sato, Michael Caplan, Mariam El-Ashmawy, Benjamin Izar, Shaheer Khan, Inderjit Mehmi, Aleigha Lawless, Theodore S. Hong, Omid Hamid, Richard D. Carvajal, Alexander Shoushtari, Ryan J. Sullivan Oct 2025

Concurrent Local Therapy Extends Clinical Benefit Of Tebentafusp In Metastatic Uveal Melanoma Patients, Tristan L. Lim, Kamaneh Montazeri, Eric Wehrenberg-Klee, Antoine Desilets, Rino S. Seedor, Marlana Orloff, Takami Sato, Michael Caplan, Mariam El-Ashmawy, Benjamin Izar, Shaheer Khan, Inderjit Mehmi, Aleigha Lawless, Theodore S. Hong, Omid Hamid, Richard D. Carvajal, Alexander Shoushtari, Ryan J. Sullivan

Kimmel Cancer Center Faculty Papers

BACKGROUND: Tebentafusp has significantly improved overall survival in HLA-A*02:01+ metastatic uveal melanoma (mUM) patients even in those with a best objective response of progressive disease. Thus, strategies to maintain tebentafusp therapy are critical. Here, we examine the efficacy and safety of adding concurrent local therapy (CLT) to tebentafusp upon radiological progression with tebentafusp alone.

PATIENTS AND METHODS: This multicenter retrospective study included mUM patients treated with tebentafusp and CLT, consisting of extrahepatic soft tissue irradiation and liver-directed therapies (LDTs). Efficacy of target and nontarget sites were assessed per RECIST version 1.1. PFS with tebentafusp alone (PFS1) was compared to that …


Regain Confidence Postpartum: A Guide For Pelvic Floor Health​, Taylor Jackson, Mary Jan Greer, Donna Carver Oct 2025

Regain Confidence Postpartum: A Guide For Pelvic Floor Health​, Taylor Jackson, Mary Jan Greer, Donna Carver

Fall 2025 OTD Capstone Symposium

Postpartum pelvic floor dysfunction can disrupt daily occupations such as toileting, hygiene, mobility, sexual health, sleep, and infant care. These challenges often reduce confidence and limit participation. Although pelvic floor issues are common, occupational therapy has not been widely recognized in this emerging area, leaving a gap in functional, client-centered support.

This capstone project developed Regain Confidence Postpartum: A Guide for Pelvic Floor Health, an occupation-focused resource designed to help postpartum individuals understand pelvic floor dysfunction and return to meaningful routines. A needs assessment was completed through clinical observation, discussions with providers at Purely Pelvic Floor, and a review …


Staying In The Game: Understanding The Impact Of Gaming On Musculoskeletal Health And Occupational Performance, Sereniti A. Forkey Dr, Zeida Gutierrez Oct 2025

Staying In The Game: Understanding The Impact Of Gaming On Musculoskeletal Health And Occupational Performance, Sereniti A. Forkey Dr, Zeida Gutierrez

Fall 2025 OTD Capstone Symposium

The purpose of this capstone is to examine the physical demands that gaming places on the musculoskeletal system and to gain a deeper understanding of gamers’ habits and behaviors. The goal of this project is to explore the population within its context, including psychosocial impacts and the potential need for intervention. By doing so, this research aims to provide valuable insights to both gamers and clinicians, supporting and enhancing occupational performance in gaming.


Increasing Play Opportunities To Improve Development And Health For Children, Kallie S. Ellis, Wendy Tremaine, Emily Bush Oct 2025

Increasing Play Opportunities To Improve Development And Health For Children, Kallie S. Ellis, Wendy Tremaine, Emily Bush

Fall 2025 OTD Capstone Symposium

Children with disabilities often experience reduced opportunities for meaningful peer play, which can negatively influence their physical, cognitive, and social-emotional development. Early childhood environments play a critical role in supporting inclusive participation, yet many barriers—physical, social, and environmental—limit access to developmentally rich play throughout the school day. The purpose of this capstone project was to develop, implement, and evaluate a Tier-1, school-based program designed to increase meaningful play opportunities for preschool children ages 3–6, with and without disabilities.

A needs assessment was conducted with teachers and parents to identify developmental concerns and participation barriers related to fine motor, gross motor, …


The Guardian The Month Of October 2025, Wright State Student Body Oct 2025

The Guardian The Month Of October 2025, Wright State Student Body

The Guardian Student Newspaper

News articles from The Guardian for the Month of October 2025. The Guardian is the official student-run newspaper for Wright State University. It has been published regularly since March of 1965.


Escape Of Kdm6a From X Chromosome Is Detrimental To Ischemic Brains Via Irf5 Signaling, Conelius Ngwa, Afzal Misrani, Kanaka Valli Manyam, Yan Xu, Shaohua Qi, Romana Sharmeen, Juneyoung Lee, Long-Jun Wu, Louise Mccullough, Fudong Liu Oct 2025

Escape Of Kdm6a From X Chromosome Is Detrimental To Ischemic Brains Via Irf5 Signaling, Conelius Ngwa, Afzal Misrani, Kanaka Valli Manyam, Yan Xu, Shaohua Qi, Romana Sharmeen, Juneyoung Lee, Long-Jun Wu, Louise Mccullough, Fudong Liu

The Brown Foundation: Institute of Molecular Medicine

The role of chromatin biology and epigenetics in disease progression is gaining increasing recognition. Genes that escape X chromosome inactivation (XCI) can impact neuroinflammation through epigenetic mechanisms. Our previous study has suggested that the X escapee genes Kdm6a and Kdm5c are involved in microglial activation after stroke in aged mice. However, the underlying mechanisms remain unclear. We hypothesized that Kdm6a/5c demethylate H3K27Me3/H3K4Me3 in microglia, respectively, and mediate the transcription of interferon regulatory factor 5 (IRF5) and IRF4, leading to microglial pro-inflammatory responses and exacerbated stroke injury. Aged (17–20 months) Kdm6a/5c microglial conditional knockout (CKO) female mice (one allele of the …