Digital Commons Network^™

A Glial Circadian Gene Expression Atlas Reveals Cell-Type And Disease-Specific Reprogramming In Response To Amyloid Pathology Or Aging, Patrick W. Sheehan, Stuart B Fass, Darshan Sapkota, Sylvia Kang, Henry C Hollis, Jennifer H Lawrence, Sohui Park, Ashish Sharma, Dorothy P Schafer, Ron C Anafi, Joseph D Dougherty, John D Fryer, Erik S Musiek

2020-Current year OA Pubs

While circadian rhythm disruption may promote neurodegenerative disease, the impact of aging and neurodegenerative pathology on circadian gene expression patterns in different brain cell types remains unknown. Here we used a translating ribosome affinity purification to identify the circadian translatomes of astrocytes, microglia and bulk tissue in healthy mouse cortex and in the settings of amyloid-β plaque pathology or aging. We show that glial circadian translatomes are highly cell-type-specific and exhibit profound, context-dependent reprogramming in response to amyloid pathology or aging. Transcripts involved in glial reactivity, immunometabolism and proteostasis, as well as nearly half of all Alzheimer's disease risk genes, …

Concerns Regarding The Standard Deviation Of Individual Responses For Assessing Treatment Response Heterogeneity, Aaron R Caldwell, David B Allison, Andrew W Brown, Gary L Gadbury, Thirupathi Reddy Mokalla, R Drew Sayer, Andrew D Vigotsky

Children’s Nutrition Research Center Staff Publications

The estimation of treatment response heterogeneity (TRH) is increasingly important as medicine moves toward personalized approaches. While various statistical methods have been proposed to quantify TRH in parallel-group trials, the standard deviation of individual responses (SDIR) has gained prominence within physiological research. This method is intended to quantify individual response variation by comparing standard deviations of change scores between intervention and control groups. We acknowledge that SDIR represents an improvement over many other flawed approaches that often involve responder counting. However, SDIR has critical limitations: 1) it cannot overcome the fundamental problem of causal inference because the correlation between potential …

Characterization Of Educational And Executive Leadership In University-Based General Surgery Programs: Demographics, Training Backgrounds, And Institutional Ties, Nicole M Santucci, Daniel Alligood, Sabrina Madrigal, Ariana Naaseh, Jonathan Davies, Hannah M Phelps, Paul E Wise, Jennifer Yu, Jesse D Vrecenak, Colin A Martin

2020-Current year OA Pubs

INTRODUCTION: Despite longstanding homogeneity in surgical leadership at academic institutions, promoting diversity in leadership positions is increasingly recognized as critical to fostering inclusion, mentorship, and improved patient outcomes. This study aims to further characterize and compare educational and executive leaders within academic general surgery (GS) programs.

METHODS: A cross-sectional study was conducted using publicly accessible online resources to collect program characteristics and leadership demographics for Accreditation Council for Graduate Medical Education-accredited, university-based GS residency programs for the 2024-25 academic year. Leadership roles included Program Directors (PDs), Associate Program Directors (APDs), Clerkship Directors (CDs), Vice Chairs of Education (VCE), and Department …

Association Of Hospital Surgical Volume With Outcomes In Resected Stage I Non-Small Cell Lung Cancer, Steven Tohmasi, Daniel B Eaton Jr, Brendan T Heiden, Nikki E Rossetti, Theodore S Thomas, Martin W Schoen, Su-Hsin Chang, Ana A Baumann, Yan Yan, Mayank R Patel, Whitney S Brandt, Bryan F Meyers, Varun Puri

2020-Current year OA Pubs

INTRODUCTION: Prior research examining the volume-outcome relationship for lung cancer resection has focused primarily on non-Veteran populations treated across diverse healthcare systems. This study aimed to evaluate the relationship between hospital surgical volume and postoperative outcomes for early-stage non-small cell lung cancer (NSCLC) in Veteran and non-Veteran populations in the United States.

METHODS: We conducted a retrospective cohort study of patients diagnosed with stage I NSCLC who underwent surgical resection in the Veterans Health Administration (VHA) from 2007-2019 and National Cancer Database (NCDB) from 2010-2019. Hospitals were categorized based on their annual volume of lung cancer resections. Multivariable regression models …

Development And Evaluation Of The Phenotypic 2g Test To Detect Drug-Resistant Tb, J. I. Garcia, E. T. Mambuque, Amberlee Hicks, Alyssa Schami, S. Munguambe, N. Gomez, G. Tembe, B. Saavedra, S.-H. Wang, Blanca I. Restrepo

School of Medicine Publications

Background: Early diagnosis of TB with drug susceptibility testing (DST) is critical to achieve successful treatment outcomes. We aimed to develop and test a novel colorimetric, 12-well, thin-layer agar-based test to assess its accuracy for TB diagnosis and DST in a clinical setting in Southern Mozambique.

Methods: Development of the first prototype of the second generation (2G) test in the laboratory setting followed by a cross-sectional diagnostic accuracy study with consecutive recruitment of subjects with microbiologically confirmed TB using GeneXpert MTB/RIF Ultra.

Results: In the laboratory setting, the 2G test showed 100% accuracy in detecting resistance of genotypically characterised drug-resistant …

Foreign Director Exit In The Midst Of Deteriorating Bilateral Political Relations, Xiaocong Tian, Yuehua Xu, Daphne W. Yiu

Research Collection Lee Kong Chian School Of Business

Amid global geopolitical realism pushing for a race of hegemonic rivalry nowadays, an outflow of global human talents is a pressing organizational concern. Our study draws attention to the underexamined phenomenon of the exit of foreign directors from their host countries during geopolitical tensions. Theorizing from a sensemaking logic, we posit that the deterioration of bilateral political relations serves as an unexpected event that activates foreign directors’ schemas for dual identity conflict, propelling them to react behaviorally to such identity threats by exiting the board in the host country. In addition, we further posit that the sensemaking process is contingent …

Front Cover

Gathered Fragments

No abstract provided.

Submission Guidelines

Gathered Fragments

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The Bishop And The Dragon: The 1920s Clash Between Catholics And The Kkk In Western Pennsylvania, Mark Holan

Gathered Fragments

No abstract provided.

Builder, Donor, Patriot, And Businessman: Oil City’S Father Thomas Carroll (1834-1898), Kathleen M. Washy

Gathered Fragments

No abstract provided.

Mother Boniface Keasey And The Missionary Servants Of The Most Blessed Trinity: Offering Hope In Mill Town, Coal Patches, And Beyond, Kerry Crawford

Gathered Fragments

No abstract provided.

The Fighting Chaplain Of The Army Of The Cumberland: The Life And Times Of Father Richard Calixtus Christy (1829-1878), Evan Portman, Kathleen M. Washy

Gathered Fragments

No abstract provided.

The Bicentennial, Captain Michael Mcguire, And Me, Blanche G. Mcguire

Gathered Fragments

No abstract provided.

Donor List

Gathered Fragments

No abstract provided.

The Catholic Historical Society Of Western Pennsylvania: The Dearden Era, John C. Bates Esq.

Gathered Fragments

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Our Authors

Gathered Fragments

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News From The Catholic Historical Society Of Western Pennsylvania

Gathered Fragments

No abstract provided.

Window Into The Past: Did Gilbert Lafayette Belan Fetterman’S Godfather Attend His Baptism?, Kathleen M. Washy

Gathered Fragments

No abstract provided.

Back Matter

Gathered Fragments

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Recalibrating Risk Under Dobbs, Yvonne F. Lindgren, Michelle Oberman

Faculty Works

In response to mounting evidence of the devastating harms patients have experienced under abortion bans, abortion opponents and the Supreme Court of Texas have argued that the bans are clear but that doctors are willfully refusing to provide care. Instead of reforming the bans, they argue that doctors should be sued in medical malpractice for their failure to meet the standard of care. This Article interrogates that claim, investigating whether the crisis in reproductive healthcare that has resulted from delayed and denied care can be remedied by suing doctors. Specifically, can medical malpractice litigation provide guardrails against the erosion in …

Small For Gestational Age Subgroups Have Differential Morbidity, Growth, And Neurodevelopment At Age 2: The Interbio-21st Newborn Study, Aris T. Papageorghiou, María C. Restrepo-Ménde, Rose Mcgready, Fernando C. Barros, Francois Nosten, Shama Munim, Roseline Ochieng, Rachel Craik, Hellen C. Barsosio, Zulfiqar Ahmed Bhutta

Department of Obstetrics & Gynaecology

Background: Small for gestational age is a complex perinatal syndrome associated with increased neonatal morbidity, mortality, and impaired childhood growth and neurodevelopment. Current classifications rely primarily on birthweight, which does not capture the heterogeneity of the condition nor predict long-term health outcomes. Here we aim to identify and characterize distinct small for gestational age subgroups and assess their neonatal and early childhood health trajectories.
Objective: To refine the classification of small for gestational age by identifying subgroups based on maternal, fetal, and environmental factors and evaluating their associations with neonatal morbidity, growth, and neurodevelopment at age 2.
Study design: Prospective …

Plasma Biomarkers In Neuropsychiatric Syndromes: A Narrative Review, Zahinoor Ismail, Dylan X Guan, Ganesh Babulal, James Bateman, Marc Cantillon, Byron Creese, Fabrizia D'Antonio, Corinne Fischer, Jennifer Gatchel, Chinedu Momoh

Brain and Mind Institute

Neuropsychiatric symptoms (NPS) are common features of neurodegenerative disease (NDD) but are relatively understudied compared to cognition, especially regarding biomarkers. Further, emerging evidence describes the utility of systematic assessment of NPS across the cognitive continuum, even in advance of dementia. In this narrative review, we discuss the role of plasma biomarkers in relation to NPS across the cognitive continuum of unimpaired, subjective cognitive decline, mild cognitive impairment, and dementia. While Alzheimer's disease is the primary focus, vascular, Lewy body, and frontotemporal dementia etiologies are also discussed. Literature searches included NPS and dementia-related search terms with additional literature identified based on …

Communicating The Green Transition - Practices And Competencies For Engineers, Paul Talbot, Una Beagon, Stephen Harper, Janet Mckennedy

Research Outputs: 2025-Present

The green transition is driving demand for engineering expertise in sectors such as renewable energy, construction, transport, and industrial decarbonisation. Projects are complex and interdisciplinary, and communication plays a central role. This report presents findings from 20 focus groups with 103 engineers across Europe examining how engineers communicate in green transition project contexts. Participants described a wide range of communicative tasks involving coordination, documentation, stakeholder engagement, and public communication.Engineers work across spoken, written, and digital modes, shifting between formal and informal styles, and adapting to varied audiences. They must navigate fragmented tools and workflows, unclear goals and roles, jargon pitfalls, …

A Schönberg Approach To Devillier V. Texas: Synthesizing Text, Structure, And History Of The Takings Clause, Jordan Fortunati

University of the Pacific Law Review

No abstract provided.

2025 Library Annual Report, James White Library

Library Administration and Marketing

No abstract provided.

Book Reviews, John C. Bates Esq.

Gathered Fragments

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Gathered Fragments Vol. Xxxv

Gathered Fragments

Full Fall 2025 issue of Gathered Fragments (Vol. XXXV).

Time To Pay For Nature-Based Solutions, Tamar Ron

New England Journal of Public Policy

Viewing nature as ‘common goods’ results in under-valuating of natural capital and assets. As a consequence, budget allocations for environmental protection, biodiversity conservation, and climate action are considerably insufficient. Another result is opting for unsustainable and destructive land and resource uses, which provide immediate and tangible monetary revenues. This article emphasizes the need to valuate natural assets and nature-based solutions (NBS), and their contribution. It further explores optional solutions, including national and global policy, and legislative and taxing instruments, to translate this value into substantive tangible financing for coordinated and synergetic approaches to address the critical global climate and biodiversity …

Stuck Or Stepping Forward: The Dual Realities Of Industry 4.0 Integration In Philippine Tvet, Rayhanah P. Mariano

Curriculum, Pedagogy, and Assessment Faculty Publications

The onset of Industry 4.0 demands for transformation in TVET curricula, pedagogy, and infrastructure. The study examines how TVET institutions integrate industry 4.0 and identifies enabling and constraining factors. This is a qualitative study, grounded in critical realism and morphogenetic approach. Semi-structured interview was conducted with TVET educators in the National Capital Region (NCR) to unpack underlying mechanisms and structural conditions influencing Industry 4.0 integration. Thematic analysis revealed five overarching dispositional themes: driving institutional integration to digital and industry 4.0 demands, strengthening collaborative partnerships and industry engagement, fostering professional development and transformative mindset, confronting infrastructural and financial challenges, and navigating …

Understanding Behavioral Engagement In Project-Based Learning: Key Influencing Factors, Maria Coney G. Pallones

English Faculty Publications

Project-Based Learning (PBL) is widely acknowledged for fostering student engagement; however, limited research explores how its specific design features influence behavioral engagement, defined as students’ active participation, persistence, and effort, particularly in early education settings. This study investigates what key factors, as perceived by teachers, influence students' behavioral engagement during PBL, and how these factors support motivation through the lens of Self-Determination Theory (SDT). Semi-structured interviews were purposively conducted with elementary teachers experienced in implementing PBL, and the data were analyzed using thematic analysis. Three key design features emerged as critical to sustaining behavioral engagement: voice, choice, and ownership, which …