Digital Commons Network^™

Effect Of Valemetostat On The Pharmacokinetics Of Midazolam And Digoxin: A Phase 1 Drug-Drug Interaction Study In Patients With Non-Hodgkin Lymphoma, Masaya Tachibana, Steven Horwitz, Eric Jacobsen, Francine Foss, Pamela Allen, Pierluigi Porcu, Tatyana Feldman, Jia Ruan, Jonathan Brammer, Jie Wang, Shinichi Inaba, Yuka Iko, Keiko Nakajima, Yasuyuki Kakurai, Noriaki Kitami, Yang Chen, Yvonne Lau

Department of Medicine Faculty Papers

Valemetostat tosylate (valemetostat) is an oral, potent, dual inhibitor of enhancer of zeste homolog (EZH)2/1, under investigation in non-Hodgkin lymphomas (NHLs) and solid tumors. In vitro, it inhibits cytochrome P450 3A (CYP3A) and P-glycoprotein (P-gp) when combined with sensitive CYP3A or P-gp substrates. This drug–drug interaction (DDI) sub-study is part of the phase 1 trial of valemetostat monotherapy (DS3201-A-J101; NCT02732275), assessing the effect of valemetostat on the pharmacokinetics (PK) of sensitive CYP3A and P-gp substrates midazolam and digoxin, respectively, in patients with relapsed or refractory NHL, and its safety and efficacy. Patients received two simultaneous single doses of midazolam and …

Cd7 Regulates The Persistence Of Terminally Exhausted Cd8 T Cells During Chronic Infection, Sean Hyslop, Colby J Hofferek, Maria V Stegantseva, Emerald Kan, Kelli A Mccord, Victor M Alvarez, Amanda Y Xia, Jacob P Conarty, Andreas Wieland, William H Hudson

Faculty, Staff and Students Publications

CD8+ T cell exhaustion limits immune responses during cancer and chronic infection. We identify CD7 as a tissue-specific regulator of terminally exhausted CD8+ T cells during chronic infection. CD7 expression progressively increases during exhaustion, reaching its highest levels on a subset of CD101+Tim3low terminally exhausted cells that arise in the liver. Transcriptomic analysis revealed that CD7-deficient terminally exhausted cells display altered expression of co-stimulatory, translational, and effector genes, correlating with markedly reduced persistence and increased apoptotic susceptibility. Importantly, CD7 is preferentially upregulated on PD-1+CD39+ tumor-infiltrating lymphocytes (TILs) in human head and neck squamous cell carcinoma (HNSCC), suggesting CD7 may play …

Higher Education Cybersecurity: A Vulnerability Assessment Of The U.S. South’S Institutional Websites, Zachary W. Taylor, Vivi Vo

Journal of Cybersecurity Education, Research and Practice

As technology continues to advance, it is critical to understand how higher education institutions protect digital information of their stakeholders including students, faculty, and staff through cybersecurity measures. Although conceptual research has articulated various aspects of cybersecurity, no empirical research has explored the cybersecurity of higher education (.edu) websites through a vulnerability scan of these websites via an open PortScan and analysis. To fill a critical gap in the literature, this study conducted a vulnerability scan and open PortScan and analysis of all higher education websites in three of the lowest-income states in the United States: Louisiana (n=112), Mississippi (n=52), …

Association Of Stepping-Up To High Dose Inhaled Corticosteroids And Risk Of Future Asthma Exacerbations: Data From The Us, Trung N Tran, Marjan Kerkhof, Tham T Le, Mina Khezrian, Nicole Zubizarreta, Joshua Enxing, Kirsty Rhodes, Jonatan Hedberg, Bill Cook, Tianshi David Wu, Tim W Harrison

Faculty, Staff and Students Publications

Background: Real-world data on the benefit of high-dose inhaled corticosteroid (ICS) post-exacerbation are limited.

Objective: To investigate whether stepping-up to high-dose inhaled corticosteroid (ICS) post-severe exacerbation reduces future asthma exacerbation risk in a real-world setting.

Methods: This was a retrospective cohort study using the Optum® Clinformatics® database (October 2015-December 2023). Patients with asthma, aged ≥12 years, with ≥1 severe exacerbation and ≥2 ICS maintenance prescriptions in the 12-months pre-, and ≥1 ICS maintenance prescription in the 3-months post-exacerbation were included. Primary and secondary endpoints were annualized asthma exacerbation rate (AAER) and time to first subsequent severe exacerbation, respectively. We compared …

A Guide To Breaking Seed Dormancy Of Common Wetland Plant Species, Samantha R. Kurkowski, Rae Robinson, Sandra E. Johnston, Montana M. Horchler, Adrienne E. Ernst, Margaret D. Haney, Karin M. Kettenring

All Current Publications

This guide was developed from a series of seed dormancy break and germination experiments conducted over 4 years with 41 species. The purpose of this guide is to synthesize the information we learned through these experiments and present the findings for those interested in breaking seed dormancy, such as land managers, restoration practitioners, and wetland researchers. Ultimately, we hope this guidance catalyzes further wetland restoration throughout the Intermountain West.

Selective Rna Sequestration In Biomolecular Condensates Directs Cell Fate Transitions, Patrizia Pessina, Mika Nevo, Junchao Shi, Srikanth Kodali, Eduard Casas, Yingzhi Cui, Alicia L Richards, Emily J Park, Xi Chen, Florencia Levin-Ferreyra, Alejandra Rivera Tostado, Erica Stevenson, Nevan J Krogan, Danielle L Swaney, Qilong Ying, Qi Chen, Justin Brumbaugh, Bruno Di Stefano

Faculty, Staff and Students Publications

Controlling stem cell differentiation is a longstanding goal in biomedical research. Here we explore how cell fate is influenced by RNA condensates, specifically P-bodies, which modulate gene expression posttranscriptionally. We profiled the transcriptomes of biomolecular condensates in diverse developmental contexts spanning multiple vertebrate species. Our analyses revealed conserved, cell type-specific sequestration of untranslated RNAs encoding cell fate regulators. P-body RNA contents do not reflect active gene expression in each cell type but are enriched for translationally repressed transcripts characteristic of the preceding developmental stage. Mechanistically, P-body contents are controlled by microRNAs and can be profoundly reshaped by perturbing AGO2 or …

Screening For Trypanosoma Cruzi In Patients Living With The Human Immunodeficiency Virus (Pwh) In The Peruvian Amazon, Silvia Otero-Rodriguez, Martin Casapia-Morales, Lilia-Lorena Pinedo-Ramirez, Esperanza Merino, Eva H Clark, José-Manuel Ramos-Rincón

Faculty, Staff and Students Publications

Introduction: Chagas disease (CD) - Trypanosoma cruzi infection - in people living with HIV (PWH), particularly those with advanced CD4 T cell depletion, can lead to severe syndromes affecting the central nervous system and the heart.

Methods: We performed a cross-sectional study to screen for CD among PWH in Iquitos, Peru, between October 2023 and May 2024, with the objective of understanding the frequency of infection in this population. Adults with confirmed HIV attending outpatient services at two regional hospitals were enrolled. Two ELISA tests (lysate and recombinant) were used, and discordant results were adjudicated by indirect chemiluminescence immunoassay (CLIA). …

Understanding Extreme-Wave Hazards On High-Energy Coasts Requires A Standardised Approach To Field Data Collection: Analysis And Recommendations, Rónadh Cox, Mary C. Bourke, Max Engel, Andrew B. Kennedy, Annie Lau, Serge Suanez, Sarah J. Boulton, Maria Alexandra Oliveira, Raphaël Paris, Dimitra Salmanidou, Michaela Spiske, Wayne Stephenson, Storm Roberts, Adam D. Switzer, Nadia Mhammdi, Niamh D. Cullen, Masashi Watanabe

School of Geography, Earth and Environmental Sciences

Coastal boulder deposits provide vital information on extreme wave events. They are crucial for understanding storm and tsunami impacts on rocky coasts, and for understanding long-term hazard histories. But study of these deposits is still a young field, and growth in investigation has been rapid, without much contactbetween research groups. Therefore, inconsistencies in field data collection among different studies hinder crosssite comparisons and limit the applicability of findings across disciplines. This paper analyses field methodologiesfor coastal boulder deposit measurement based using an integrated database (ISROC-DB), and demonstrates inconsistencies in current approaches. We use the analysis as a basis for outlining …

Impact Of Transplant Conditioning, Npm1 Mutations, And Measurable Residual Disease In Flt3-Itd Acute Myeloid Leukemia, Mark J Levis, Geoffrey L Uy, Et Al.

2020-Current year OA Pubs

We conducted a post hoc analysis of data from Blood and Marrow Transplant Clinical Trials Network 1506 (MORPHO), a randomized trial of gilteritinib vs placebo as posttransplantation maintenance for patients with FLT3-ITD-mutated acute myeloid leukemia (AML) undergoing allogeneic hematopoietic cell transplantation (HCT), focusing the interactions between conditioning regimen intensity, measurable residual disease (MRD), and NPM1 comutation status reported from diagnosis. Comparing FLT3-ITD MRD before and after conditioning, there was no difference between myeloablative conditioning (MAC) and reduced-intensity conditioning (RIC) in eradication or reduction of FLT3-ITD MRD. For participants who were FLT3-ITD MRD negative before HCT, there was no difference in …

Grapes Gone Sour: Navigating Corruption In Cisg Contracts, Ingeborg Schwenzer, Cesar Pereira, Lorenzo Galan

National Law School Business Law Review

No abstract provided.

Formation And Dramatic Significance Of The “Separation” System In Ming Dynasty Southern Opera Scripts, Zhiyong Chen

Theoretical Studies in Literature and Art

The practice of “fenchu” (separation) marks a pivotal development in the Ming dynasty's chuanqi playwriting system, manifesting as either “implicit” or “explicit” separation within early Southern Opera texts. The late Ming period saw enhancements in the separation methodologies within actors' performance manuscripts and reader-oriented printed editions, improving upon the character entry and exit strategies from the Song, Yuan, and early Ming operas. This led to the formulation of separation standards that reconcile character transitions, scene consistency, and narrative cohesion. The emergence of the separation mechanism in Southern Opera is attributed to multifaceted causes: for performance scripts, it facilitated …

The Movement For The Popularization Of Literature And Art: Development And Transformation, Yanqiu Zhao

Theoretical Studies in Literature and Art

The major issues and fundamental perspectives concerning the popularization of literature and art can be broadly categorized into six aspects: the direction of development, the object of service, the subject of creation, the content and form, the language, and the evaluation of the May Fourth and New Culture Movements. While the theory and practice of the popularizing literature and art hold positive significance, they are also subject to biases and limitations. Mao Zedong, rather than merely perpetuating the ideals and objectives of the movement, deconstructed, synthesized and reformed its content and issues. He proposed his own insights and solutions to …

Balispirit Festival As A Regenerative Event Transformation Model: The Tri Hita Karana Framework In Support Of Sustainable Spiritual Tourism, Maha Dewi

Journal of Indonesian Tourism and Policy Studies

The global tourism sector is undergoing a transition toward Regenerative Tourism (RT). RT emphasizes active ecosystem restoration and community empowerment, surpassing the objectives of passive sustainability. In Bali, this transition appears in the Trilogy of Serenity, Spirituality, and Sustainability. This study examines the BaliSpirit Festival (BSF) as a case study that operationalizes the local Tri Hita Karana (THK) philosophy. This philosophy integrates spiritual (Parhyangan), social (Pawongan), and environmental (Palemahan) harmony as its foundation. The study uses a descriptive-analytical qualitative methodology to evaluate BSF's practices in advancing Sustainable Spiritual Tourism (SST). Results show BSF has established a culturally grounded regenerative event …

Digital Marketing Opportunities For The Advancement Of The Tourism Industry Case Study: Indihome Pt. Telekomunikasi Indonesia, Abiyyu Sangaji

Journal of Indonesian Tourism and Policy Studies

Digital marketing is becoming increasingly important in the tourism industry as a way to reach a wider target market and increase sales. This study uses a qualitative descriptive method aimed at exploring digital marketing opportunities in the tourism industry through a case study of IndiHome PT. Telekomunikasi Indonesia. The results of the study indicate that digital marketing can provide significant opportunities for the tourism industry, particularly in terms of the use of social media, websites, and engaging visual content. Furthermore, the results also show that the use of data and analytics can help companies optimize their digital marketing campaigns. However, …

Carlos Ferran, Dba, Ed.D., Km, Carlos Ferran

Faculty Research Mixer

No abstract provided.

Laura Honegger, Ph.D., Lcsw, Laura Honegger

Faculty Research Mixer

No abstract provided.

Embracing Artificial Intelligence And Digital Health In Cancer Care, Pavitra P. Krishnamani

Advances in Cancer Education and Quality Improvement

Digital health technologies like AI, telemedicine, and wearables are revolutionizing cancer care by enabling earlier detection, personalized treatment, and improved patient support and access.

High Turnover On The Menu - Understanding Post-Covid Employee Retention Rates Within Public Assembly Venues In New York City, Liberty University

Sport Leadership Summit

This study explores food and beverage employee turnover rates within sport venues in New York City. The topic holds public interest due to the documented correlation between guest satisfaction and employee satisfaction. It is ethical and feasible, focusing on real-world management challenges in the hospitality industry. By narrowing the scope to a specific population, the study aims to provide actionable insights into employee retention in a post-Covid landscape.

Development Pathways In Soccer - A Comparative Study Of U.S. Academies, Ncaa Programs, And European Systems, Liberty University

Sport Leadership Summit

This study seeks to compare the soccer development pathways of U.S. youth club academy systems, NCAA collegiate programs, and European youth club academy systems. Along with this, the research aims to identify what creates a factor of success. Additionally, it will focus on what specifically the club and college systems are doing collectively to develop their rosters. This comparison offers value in that it provides cumulative information on the biggest developmental soccer programs in the world. Additionally, it brings to light the differences amongst the pathways to better showcase factors of success and allow for future improvements to be made …

Private Equity And Llc Models In College Athletics - Emerging Revenue Strategies In The Power Four, Liberty University

Sport Leadership Summit

Prompted by the University of Kentucky’s formation of a not-for-profit LLC as a revenue strategy, this study investigates the impact and future implications of LLCs and private equity in NCAA athletic departments. The rationale is rooted in the growing financial pressures and opportunities following the House settlement, with athletic directors seeking innovative ways to generate revenue. This research aims to understand how these models affect revenue generation and distribution across Power Four programs.

Social Media Marketing And Fan Engagement - A Quantitative Study Of Nba Strategies, Liberty University

Sport Leadership Summit

This study investigates how different forms of social media marketing—specifically pictures, graphics, and reels—impact fan engagement in the NBA. As digital platforms increasingly replace traditional media, understanding which strategies most effectively engage fans is crucial for sports organizations. The study is grounded in existing research and uses Instagram analytics to assess engagement metrics, offering practical insights for marketing teams.

The Beauty Of Uniquity - A Regression Analysis Of Mlb Pitchers With Anomalous Arm Angles, Liberty University

Sport Leadership Summit

This study examines the effect of arm angle on pitcher success and the potential for injury prevention based on arm angle. With the rise of advanced metrics like Statcast, pitcher mechanics—especially arm angle—have become key indicators of performance. The research explores how different arm angles influence pitch movement, velocity, and injury risk, suggesting that pitchers with a “low ¾ arm angle” may best balance performance and long-term arm health.

The Correlation Between Tommy John Surgery And Pitching Velocity, Liberty University

Sport Leadership Summit

This study investigates the relationship between increasing fastball velocity and the rising number of Tommy John surgeries (UCL reconstructions) among Major League Baseball pitchers. The rationale is to understand whether higher pitching velocities contribute to injury risk and to equip coaches and trainers with tools to identify warning signs and prevent future injuries.

Televised Youth Sport And Athlete Well-Being - A Study Of The Little League World Series, Liberty University

Sport Leadership Summit

This study analyzes the commercialization of the Little League World Series (LLWS) and its psychological effects on young athletes, including stress, identity, and enjoyment. The rationale stems from growing concerns about media pressure and public attention on children in sport. The study is ethical, feasible, and valuable for understanding how televised youth events may impact athlete well-being and development.

Designing An Electronic Patient-Reported Outcomes Information Infrastructure Supported By The Re-Aim Implementation Framework, Amy C. Moreno, Angela Peek, Toshiko S. Stein, Kevin R. Shook, Sara M. Ali, Laia Humbert-Vidan, Aileen Chen, Miriam Lango, Anna Lee, Michael Spiotto, William H. Morrison, Adam S. Garden, Jack Phan, Steven J. Frank, Katherine Hutcheson, David I. Rosenthal, Clifton D. Fuller, G Brandon Gunn

Advances in Cancer Education and Quality Improvement

Objective: Patient-reported outcomes (PROs) contain valuable information that can be leveraged by providers to perform timely interventions and improve quality of life and survival. However, the implementation of electronic PROs (ePROs) remains a challenge from technical and evaluation perspectives. Our objective was to construct a robust electronic health record (EHR)-integrated ePRO information infrastructure founded on RE-AIM (reach-effectiveness-adoption-implementation-maintenance) principles.

Materials and Methods: We used Epic Systems as our EHR platform to build the MD Anderson Symptom Index Head and Neck Module (MDASI-HN) for release to all patients undergoing evaluation and/or treatment in our HN Radiation Oncology clinics. RE-AIM metrics were …

Destined To Fail [Book Review], Jessica Schomberg

Disability in LIS (DisLIS)

A deep dive into the eugenical ideas that grounded the work of influential educator and psychologist Carl E. Seashore. While Seashore was working a century ago, the author demonstrates how his ideas continue to influence education today.

Clinical Instructors In Gynecologic Oncology: Addressing Gaps In Cancer-Related Care And Gynecology Training Deficiencies, Sadhvi Batra, Ann Marie Mercier, Robert Wenham

Advances in Cancer Education and Quality Improvement

The shift toward minimally invasive techniques and sub-specialization in gynecology has reduced generalist surgical experience, prompting new training roles to better manage complex benign conditions and cancer survivorship.

Exploring Patient Perspectives On The Availability And Demand For Patient-Friendly Resources In Non-Small Cell Lung Cancer, Danielle Brazel, Aakash Desai, Fawzi Abu Rous, Jill Feldman, Eric Singhi

Advances in Cancer Education and Quality Improvement

Introduction: The growing emphasis on patient-centered care, along with the rise of open-access publications and online platforms, has increased patient demand for education about their medical conditions. In this context, patient-friendly language summaries of fundamental cancer clinical trials may be valuable resources for patients to learn more about their disease and treatment options.

Methods: We surveyed patients diagnosed with non-small cell lung cancer (NSCLC) to assess the availability and need for easy-to-understand resources related to treatment decision-making and side effect profiles. Patients were also provided an example patient-friendly language summary and asked for feedback.

Results: One hundred fourteen patients responded …

The Use Of Firgun To Improve Burnout And Workplace Civility In A Pediatric Cancer Center, Karen Moody, Jerry Stein, Deena Levine, Arshia Madni, Clark R. Andersen, Amy Heaton, Alakh P. Rajan, Demetrios Petropoulos, Jian Wang, Deborah Kramer

Advances in Cancer Education and Quality Improvement

Burnout afflicts 35% to 44% of pediatric oncology physicians, nurses, and interprofessional staff and is related to excessive workloads and emotional exhaustion. Conversely, a healthy work environment is a protective factor for burnout among physicians and nurses. Meaningful recognition is a published standard necessary for creating a healthy work environment. This study aimed to reduce staff burnout through firgun, defined as a heartfelt way to express accomplishments of another person. Pediatric oncology staff completed a firgun educational module and logged acts of firgun during a 3-month study period. Validated measures assessing burnout, workplace civility, well-being, work-life balance, and perceived …

Sport Leadership Summit Summary, Liberty University

Sport Leadership Summit

Monday, October 27, 2025

8:45 – 9:10 a.m. – Check-In

9:15 – 11:45 a.m. – Panel Discussions

12:00 – 1:00 p.m. – Lunch & Keynote

1:00 – 2:00 p.m. – Research: Oral Presentations

2:00 – 4:00 p.m. – Panel Discussions

4:00 – 4:30 p.m. – Wrap-Up

Tuesday, October 28, 2025

8:45 – 9:10 a.m. – Check-In

9:15 – 11:45 a.m. – Panel Discussions

12:00 – 1:00 p.m. – Lunch & Keynote

1:00 – 2:00 p.m. – Research: Poster Presentations

2:00 – 4:00 p.m. – Panel Discussions

4:00 – 4:30 p.m. – Wrap-Up