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October 28, 2025 Ereporter, University Of Alabama At Birmingham Oct 2025

October 28, 2025 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.


Spartan Daily, October 28, 2025, San Jose State University, School Of Journalism And Mass Communications Oct 2025

Spartan Daily, October 28, 2025, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2025

Volume 165, Issue 28


The George-Anne Inkwell Edition, Georgia Southern University Oct 2025

The George-Anne Inkwell Edition, Georgia Southern University

The Inkwell

No abstract provided.


Anti-Fatigue Effects Of Euglena Extract On Mice, Zhang Jun, Xu Bin, Xi Yanli, Zheng Minghai, Han Yuxuan, Li Huimin Oct 2025

Anti-Fatigue Effects Of Euglena Extract On Mice, Zhang Jun, Xu Bin, Xi Yanli, Zheng Minghai, Han Yuxuan, Li Huimin

Food and Machinery

[Objective] To study the effects of euglena extract on the anti-fatigue and antioxidant free radical levels in mice, and to explore its specific mechanism. [Methods] A total of 40 healthy adult male Kunming mice are randomly divided into a control group (normal saline is used instead of injection to establish fatigue mice models), a low dose group (euglena extract 0.25 g/kg BW), a medium dose group (euglena extract 0.5 g/kg BW), and a high dose group (euglena extract 1.5 g/kg BW). The groups of different doses are administered by gavage. The exhaustive swimming time and fatigue rotarod test time are …


Extraction Process Optimization Of Alcohol-Soluble Proteins From Highland Barley Fermentation Spent And In Vitro Antioxidant Properties, Lyu Qian, Zhao Jie, Song Yangbo, Xu Dan, Geng Guigong, Zhang Yiquan Oct 2025

Extraction Process Optimization Of Alcohol-Soluble Proteins From Highland Barley Fermentation Spent And In Vitro Antioxidant Properties, Lyu Qian, Zhao Jie, Song Yangbo, Xu Dan, Geng Guigong, Zhang Yiquan

Food and Machinery

[Objective] To optimize the extraction process of alcohol-soluble proteins from highland barley fermentation spent, aiming to enhance the added value of byproducts from highland barley wine processing. [Methods] The alcohol-soluble proteins were extracted from highland barley fermentation spent using ultrasound-assisted ethanol extraction. The yield of alcohol-soluble proteins was used as the evaluation index to analyze the effects of four factors, i.e., solid-to-liquid ratio, ultrasound temperature, ultrasound power, and ultrasound time, on the protein yield. An orthogonal test was conducted to optimize the extraction process and determine the optimal extraction conditions. SDS-PAGE analysis was performed to examine the relative molecular mass …


Spectroscopic Investigation Of Plasma Parameters In An Iron Target: A Comparative Study Of Different Laser Energies, Hiba A. Abed, Sabah N. Mazhir, Saeed N. T. Alrashid Oct 2025

Spectroscopic Investigation Of Plasma Parameters In An Iron Target: A Comparative Study Of Different Laser Energies, Hiba A. Abed, Sabah N. Mazhir, Saeed N. T. Alrashid

Baghdad Science Journal

Laser-Induced Breakdown Spectroscopy (LIBS) has emerged as a powerful technique for analyzing materials through the creation of plasma by laser ablation. In this study, we present a comprehensive investigation of plasma parameters in an Fe target using LIBS spectroscopy. The experiment involved using a high-power laser to ablate the Fe target, generating a plasma plume that emitted characteristic spectral lines. By analyzing the emitted light, we extracted valuable information about the plasma parameters, including electron temperature, electron density, and ionization degrees. The LIBS setup was carefully calibrated and optimized to ensure accurate and reliable measurements. The obtained spectra were employed …


Numerical Solutions Of Poisson Problem By Using Finite Element Method Based On Linear, Quadratic, And Cubic Polynomials, Ali Kamil Al-Abadi, Shurooq Kamel Abd Oct 2025

Numerical Solutions Of Poisson Problem By Using Finite Element Method Based On Linear, Quadratic, And Cubic Polynomials, Ali Kamil Al-Abadi, Shurooq Kamel Abd

Baghdad Science Journal

The finite element approach, which uses linear, quadratic, and cubic polynomials, can solve the elliptic form of the Poisson equation. This allows the method to provide a solution to the Poisson problem. This possibility arises from the structure within which the method operates. This work aims to provide an analysis of the technique in question and demonstrate its potential for applications in both square and circular dimensions. In conducting this investigation, a direct solution of the system of linear equations was used. Obtaining optimal error estimates in the L2 and H1 norms is possible for us if we …


On The Statistical Variation Of Γ-Covers Controlled By The Class Of Weight Functions, Parthiba Das, Jalal Hatem Hussein Al-Bayati, Prasenjit Bal Oct 2025

On The Statistical Variation Of Γ-Covers Controlled By The Class Of Weight Functions, Parthiba Das, Jalal Hatem Hussein Al-Bayati, Prasenjit Bal

Baghdad Science Journal

In this study, the notion of the star operator and the class of weight functions defined on the entire natural number set ℕ have been used to develop a version of the statistical cover of a topological space. In this version of statistical γ-cover, the pace of statistical convergence is mostly controlled by the selected weight function. A map g defined as g:ℕ→[0,∞)such that limn→∞g(n)=∞ and limn→∞⁄ng(n)≠0is called a weight function. Relationships between several γ …


An Analytical Review Of Brainwave Analysis For Mind-Controlled Drones: Utilizing Hybrid Neural Networks And Motor Imagery, Ather Salah Hadi Al-Isawi, Sufri Muhammad, Novia Indriaty Admodisastro, Siti Anom Ahmad, Raihani Mohamed Oct 2025

An Analytical Review Of Brainwave Analysis For Mind-Controlled Drones: Utilizing Hybrid Neural Networks And Motor Imagery, Ather Salah Hadi Al-Isawi, Sufri Muhammad, Novia Indriaty Admodisastro, Siti Anom Ahmad, Raihani Mohamed

Baghdad Science Journal

Brain-computer interfaces (BCIs) provide direct drone control by interpreting motor imagery brain impulses. This review paper critically assesses the progress made in using hybrid neural networks and motor imagery to operate mind-controlled drones and addresses the challenges of encoding and decoding complex brain signals for precise and reliable drone control. In this review paper, the primary objective is to analyze and synthesize the latest brainwave analysis technologies, focusing on hybrid neural networks and motor imagery tasks for drone control via brain-computer interfaces. This study aims to provide insights into the effectiveness of these technologies in enhancing the accuracy and reliability …


New Economic Hub Proposal In West Java Based On Toll Road Connectivity Using Community Detection, Ichwanul Muslim Karo Karo, Mohd Farhan Bin Md. Fudzee, Shahreen Binti Kasim, Azizul Azhar Ramli Oct 2025

New Economic Hub Proposal In West Java Based On Toll Road Connectivity Using Community Detection, Ichwanul Muslim Karo Karo, Mohd Farhan Bin Md. Fudzee, Shahreen Binti Kasim, Azizul Azhar Ramli

Baghdad Science Journal

A region's economic activity has a significant impact on the growth of its surroundings. Adequate connectivity (e.g., toll roads, railways, airlines and others) are essential to the inter-regional economy and encourage new economic hub. Indonesia is intensively constructing toll road infrastructure and West Java province has the highest number of planned/operating it. This study aims to identify new economic hubs in West Java based on connectivity between regencies/cities with toll roads. The new hubs are identified by using a community detection approach. To support the idea, this study illustrates cities/regencies as vertices and connectivity of cities/regencies with toll roads as …


Early Intratracheal Budesonide To Reduce Bronchopulmonary Dysplasia In Extremely Preterm Infants: The Budesonide In Babies (Bib) Randomized Clinical Trial, Namasivayam Ambalavanan, Waldemar A Carlo, Kayla J Nowak, Laura Elizabeth Wiener, Shirley S Cosby, Abhay J Bhatt, Kristi L Watterberg, Brenda B Poindexter, Martin Keszler, Carl T D'Angio, Luc P Brion, Vivek Narendran, Carrie A Rau, C Michael Cotten, Matthew M Laughon, Abhik Das, Matthew A Rysavy, Anna Maria Hibbs, Janell Fuller, Karen M Puopolo, Anup Katheria, Ravi M Patel, Jennifer R Bermick, Abbot R Laptook, Irina Prelipcean, Myra H Wyckoff, Ryan Moore, Stephanie L Merhar, Robin K Ohls, Bradley A Yoder, Marta Perez, Sarvin Ghavam, Lauritz R Meyer, Valerie Y Chock, Sara B Demauro, Wesley M Jackson, Deepali Handa, Michele C Walsh Oct 2025

Early Intratracheal Budesonide To Reduce Bronchopulmonary Dysplasia In Extremely Preterm Infants: The Budesonide In Babies (Bib) Randomized Clinical Trial, Namasivayam Ambalavanan, Waldemar A Carlo, Kayla J Nowak, Laura Elizabeth Wiener, Shirley S Cosby, Abhay J Bhatt, Kristi L Watterberg, Brenda B Poindexter, Martin Keszler, Carl T D'Angio, Luc P Brion, Vivek Narendran, Carrie A Rau, C Michael Cotten, Matthew M Laughon, Abhik Das, Matthew A Rysavy, Anna Maria Hibbs, Janell Fuller, Karen M Puopolo, Anup Katheria, Ravi M Patel, Jennifer R Bermick, Abbot R Laptook, Irina Prelipcean, Myra H Wyckoff, Ryan Moore, Stephanie L Merhar, Robin K Ohls, Bradley A Yoder, Marta Perez, Sarvin Ghavam, Lauritz R Meyer, Valerie Y Chock, Sara B Demauro, Wesley M Jackson, Deepali Handa, Michele C Walsh

Faculty, Staff and Student Publications

Importance: Extremely preterm infants are at high risk for bronchopulmonary dysplasia (BPD) and death. Multiple small randomized clinical trials showed that a combination of budesonide with surfactant compared with surfactant alone reduced BPD or death.

Objective: To determine if early intratracheal administration of a combination of budesonide (0.25 mg/kg) mixed with surfactant, compared with surfactant alone, reduces physiologic BPD or death by 36 weeks' postmenstrual age in extremely preterm infants.

Design, setting, and participants: This double-masked randomized clinical trial was conducted from April 2021 to June 2024 in the 17 centers of the United States Neonatal Research Network. Infants 22 …


Enhancing Hand Hygiene Compliance Among Icu And Nicu Visitor Families: The Impact Of Advanced Nursing Roles, The Barriers And Challenges: A Review, Siti Azuna Abu Bakar, Khin Thandar Aung, Sahrom Abdullah Oct 2025

Enhancing Hand Hygiene Compliance Among Icu And Nicu Visitor Families: The Impact Of Advanced Nursing Roles, The Barriers And Challenges: A Review, Siti Azuna Abu Bakar, Khin Thandar Aung, Sahrom Abdullah

Individual Articles

Proper hand hygiene is crucial for preventing,, infections in intensive care units (ICUs) and neonatal intensive care units (NICUs). Despite the awareness among healthcare personnel and visitors of its importance, compliance with regulations is often inadequate. Advanced nurse educators and infection control professionals can significantly improve these habits. This review investigates whether advanced nursing positions improve hand hygiene among ICU and NICU families, as well as visitors, focusing on enhancing hand hygiene programs, identifying effective solutions, recognising practice shortcomings, and providing recommendations. The methodology involved a search of databases, including PubMed, CINAHL, Scopus, and Google Scholar, using relevant keywords related …


From Listening To Action: Building Effective Community-Academic Partnerships In Environmental Health [Lightning Talk], Dani Mcbride Oct 2025

From Listening To Action: Building Effective Community-Academic Partnerships In Environmental Health [Lightning Talk], Dani Mcbride

University Faculty Publications and Creative Works

The slides from a lightning talk given at the Michigan Premier Public Health Conference in Muskegon, MI on October 28, 2025.


Collecting Hurricane Katrina Oral Histories: Amplifying Campus Voices, Chandler D. Smith Oct 2025

Collecting Hurricane Katrina Oral Histories: Amplifying Campus Voices, Chandler D. Smith

Library Faculty Publications

Background: A look at the process of the creation of an oral history project about Hurricane Katrina at LSU Health New Orleans Libraries.

Description: Hurricane Katrina was a major event for our campus and region. This year is a major anniversary of the event, and we wanted to memorialize the hard work, struggles and stories people had about Hurricane Katrina and its recovery. A search was done to see what oral histories had been done about Hurricane Katrina. Next, we checked with our Institutional Review Board (IRB) to see if approval was needed for the project. Our IRB determined that …


A Comparative Study For Classical Machine Learning Models For Swahili Social Media Sentiment Analysis, Mahadia Tunga, Davis David Oct 2025

A Comparative Study For Classical Machine Learning Models For Swahili Social Media Sentiment Analysis, Mahadia Tunga, Davis David

Tanzania Journal of Science

Despite sentiment analysis being one of the most popular applications in Natural Language Processing (NLP), most studies are skewed towards languages with a rich corpus (language database). Less emphasis has been placed on low-resource languages like Swahili. Swahili is the official language of the African Union and of 4 countries in East Africa, and is spoken by many people on the African continent. This study performed sentiment analysis using 3,000 tweets hosted on the Zindi Africa platform. Data was processed using a term frequency-inverse document frequency vectorization method, and five classical machine learning algorithms (RandomForest, XgBoost, and CatBoost, HistogramGradientBoost, LightGradientBoos) …


Heavy Metal Contamination And Health Risks In Katoro's Artisanal Gold Mining Soils, Tanzania, Innocent J. Lugendo, Venance Mwesiga Oct 2025

Heavy Metal Contamination And Health Risks In Katoro's Artisanal Gold Mining Soils, Tanzania, Innocent J. Lugendo, Venance Mwesiga

Tanzania Journal of Science

This study assessed heavy metal contamination in surface soils from artisanal gold mining areas in Katoro, Tanzania, evaluating ecological and human health risks. Thirty-six soil samples were systematically collected from three mining villages (Bingwa, Isenye, and CCM) at varying distances ranging from 30 to 90 m from active mining pits alongside twelve control samples from a non-mining area for comparison purposes. Concentrations of Cr, Cu, Ni, Zn, Pb, and As in soil samples were analyzed using energy-dispersive X-ray fluorescence spectrometry (EDXRF). Results revealed severe contamination, with Cr (117–1255 mg/kg), Cu (81–104 mg/kg), and Ni (89–271 mg/kg) exceeding permissible limits. The …


Comparative Analysis Of Targeted Rna-Seq And Optical Genome Mapping For Detecting Gene Rearrangements In Acute Leukemia, Chi Young Ok, Guilin Tang, Sanam Loghavi, Shimin Hu, Qing Wei, Andres E Quesada, Mark J Routbort, Rashmi Kanagal-Shamanna, C Cameron Yin, Iman Sarami, Sofia Garces, Nitin K Agarwal, Raja Luthra, Hong Fang, Fatima Zahra Jelloul, Julian Bryan, L Jeffrey Medeiros, Keyur P Patel, Gokce A Toruner Oct 2025

Comparative Analysis Of Targeted Rna-Seq And Optical Genome Mapping For Detecting Gene Rearrangements In Acute Leukemia, Chi Young Ok, Guilin Tang, Sanam Loghavi, Shimin Hu, Qing Wei, Andres E Quesada, Mark J Routbort, Rashmi Kanagal-Shamanna, C Cameron Yin, Iman Sarami, Sofia Garces, Nitin K Agarwal, Raja Luthra, Hong Fang, Fatima Zahra Jelloul, Julian Bryan, L Jeffrey Medeiros, Keyur P Patel, Gokce A Toruner

Faculty, Staff and Student Publications

Background/Objectives: Gene rearrangements involving oncogenes are major drivers in acute leukemia, influencing disease classification, prognosis, and therapeutic decision-making. Targeted RNA sequencing (RNA-Seq) panels capable of detecting intergenic and intragenic fusions across multiple genes are increasingly used in diagnostic settings. However, comparative evaluation with orthogonal technologies remains limited.

Material and Methods: We compared the performance of a 108-gene anchored multiplex PCR (AMP)-based RNA-Seq panel with that of Optical Genome Mapping (OGM) in 467 acute leukemia cases. The cohort included 360 cases of acute myeloid leukemia (AML), 89 B-lymphoblastic leukemia (B-ALL), 12 T-lymphoblastic leukemia (T-ALL), and 6 cases of mixed phenotype …


Dissecting The Intrinsic And Extrinsic Regulators Of Prostate Cancer Dormancy In The Bone Microenvironment, Mostafa M. Nasr Oct 2025

Dissecting The Intrinsic And Extrinsic Regulators Of Prostate Cancer Dormancy In The Bone Microenvironment, Mostafa M. Nasr

USF Tampa Graduate Theses and Dissertations

Metastatic disease is the primary driver of cancer-related mortality. In prostate cancer (PCa), patient survival decreases dramatically once the disease spreads to distant organs, with over 80% of metastases occurring in the bone. This dissemination is often followed by a clinically silent period of tumor dormancy that can last for years, creating a critical reservoir of cells poised for lethal relapse. A significant barrier to understanding and targeting this dormant phase has been the lack of robust experimental models. This thesis first addresses this challenge by establishing a novel stress-induced model of PCa dormancy, validated across multiple murine and human …


Second-Generation Iranian American Parents’ Perception Of Heritage Language Maintenance Through The Home And Ethnolinguistic Supports In The United States., Zohre Sarlak-Ghassemi Oct 2025

Second-Generation Iranian American Parents’ Perception Of Heritage Language Maintenance Through The Home And Ethnolinguistic Supports In The United States., Zohre Sarlak-Ghassemi

Electronic Theses and Dissertations Archive

Abstract This qualitative study examines the Family Language Policy (FLP) of second-generation Iranian American (SGIA) parents regarding the maintenance of their heritage language (HL), specifically Persian, within two U.S. contexts: Orange County, California, and Memphis, Tennessee. Based on Curdt-Christiansen and Huang’s (2020) dynamic FLP model and Bronfenbrenner’s (1979) ecological systems theory, the research examines parental language ideologies and the impact of perceived ethnolinguistic vitality of their communities on their language ideologies. Semi-structured interviews and background questionnaires with ten families (primarily mothers, with some fathers) revealed complex and hybrid language ideologies. All participants expressed emotional and identity-related attachments to Persian, viewing …


The Horror And The Passion: The Christian/Secular Paradigm In The Twentieth-Century Southern Gothic, Matthew Ryan Pike Oct 2025

The Horror And The Passion: The Christian/Secular Paradigm In The Twentieth-Century Southern Gothic, Matthew Ryan Pike

Electronic Theses and Dissertations Archive

The goal of this dissertation is to provide a foundational definition of the southern gothic literary genre. In this analysis, I argue that the core of the southern gothic is a Christian/secular paradigm and that all of the conflict within these narratives is principally grounded in this dichotomy. Not only does this framework provide the best interpretive lens to understand the genre, but it ameliorates the cloud of confusion in the critical scholarship, wherein a wide and fluid array of propositions are advanced on what essentially comprises the southern gothic. I execute this via an interdisciplinary strategy, adopting scholarship and …


A Guide To Breaking Seed Dormancy Of Common Wetland Plant Species, Samantha R. Kurkowski, Rae Robinson, Sandra E. Johnston, Montana M. Horchler, Adrienne E. Ernst, Margaret D. Haney, Karin M. Kettenring Oct 2025

A Guide To Breaking Seed Dormancy Of Common Wetland Plant Species, Samantha R. Kurkowski, Rae Robinson, Sandra E. Johnston, Montana M. Horchler, Adrienne E. Ernst, Margaret D. Haney, Karin M. Kettenring

All Current Publications

This guide was developed from a series of seed dormancy break and germination experiments conducted over 4 years with 41 species. The purpose of this guide is to synthesize the information we learned through these experiments and present the findings for those interested in breaking seed dormancy, such as land managers, restoration practitioners, and wetland researchers. Ultimately, we hope this guidance catalyzes further wetland restoration throughout the Intermountain West.


Understanding Extreme-Wave Hazards On High-Energy Coasts Requires A Standardised Approach To Field Data Collection: Analysis And Recommendations, Rónadh Cox, Mary C. Bourke, Max Engel, Andrew B. Kennedy, Annie Lau, Serge Suanez, Sarah J. Boulton, Maria Alexandra Oliveira, Raphaël Paris, Dimitra Salmanidou, Michaela Spiske, Wayne Stephenson, Storm Roberts, Adam D. Switzer, Nadia Mhammdi, Niamh D. Cullen, Masashi Watanabe Oct 2025

Understanding Extreme-Wave Hazards On High-Energy Coasts Requires A Standardised Approach To Field Data Collection: Analysis And Recommendations, Rónadh Cox, Mary C. Bourke, Max Engel, Andrew B. Kennedy, Annie Lau, Serge Suanez, Sarah J. Boulton, Maria Alexandra Oliveira, Raphaël Paris, Dimitra Salmanidou, Michaela Spiske, Wayne Stephenson, Storm Roberts, Adam D. Switzer, Nadia Mhammdi, Niamh D. Cullen, Masashi Watanabe

School of Geography, Earth and Environmental Sciences

Coastal boulder deposits provide vital information on extreme wave events. They are crucial for understanding storm and tsunami impacts on rocky coasts, and for understanding long-term hazard histories. But study of these deposits is still a young field, and growth in investigation has been rapid, without much contactbetween research groups. Therefore, inconsistencies in field data collection among different studies hinder crosssite comparisons and limit the applicability of findings across disciplines. This paper analyses field methodologiesfor coastal boulder deposit measurement based using an integrated database (ISROC-DB), and demonstrates inconsistencies in current approaches. We use the analysis as a basis for outlining …


The Life Of A Copyright, Annabel Haddock Oct 2025

The Life Of A Copyright, Annabel Haddock

Cardozo Arts & Entertainment Law Journal (AELJ) Blog

On August 23rd, 2021, stand-up comedian Caroline Timoney posted a TikTok video where she stated, “I fear I may have girl bossed a little too close to the sun.” The video went viral and, to this day, it is her most viewed post on the platform, with upwards of seven and a half million views as of October 13, 2025, and over twenty-four thousand videos reposted using her audio. Taylor Swift’s twelfth and most recent album, The Life of a Showgirl, was released on October 3rd, 2025, and includes a song titled “CANCELLED!” featuring the lyric “Did you girlboss …


Parco V. Fisch Oct 2025

Parco V. Fisch

All Decisions

The court denied the tenant's motion to dismiss a holdover petition, finding the predicate notice sufficient despite lacking detailed small landlord exemption proof. The landlord was permitted to amend the petition to include Good Cause Eviction Law (GCEL) small landlord exemption information required by RPL § 214(1), as such pleading defects are amendable. The tenant's motion for leave to file an answer was largely granted, and limited discovery was ordered regarding the landlord's claimed exemption and the tenant's harassment counterclaims, while overly broad discovery demands were stricken.


Effect Of Valemetostat On The Pharmacokinetics Of Midazolam And Digoxin: A Phase 1 Drug-Drug Interaction Study In Patients With Non-Hodgkin Lymphoma, Masaya Tachibana, Steven Horwitz, Eric Jacobsen, Francine Foss, Pamela Allen, Pierluigi Porcu, Tatyana Feldman, Jia Ruan, Jonathan Brammer, Jie Wang, Shinichi Inaba, Yuka Iko, Keiko Nakajima, Yasuyuki Kakurai, Noriaki Kitami, Yang Chen, Yvonne Lau Oct 2025

Effect Of Valemetostat On The Pharmacokinetics Of Midazolam And Digoxin: A Phase 1 Drug-Drug Interaction Study In Patients With Non-Hodgkin Lymphoma, Masaya Tachibana, Steven Horwitz, Eric Jacobsen, Francine Foss, Pamela Allen, Pierluigi Porcu, Tatyana Feldman, Jia Ruan, Jonathan Brammer, Jie Wang, Shinichi Inaba, Yuka Iko, Keiko Nakajima, Yasuyuki Kakurai, Noriaki Kitami, Yang Chen, Yvonne Lau

Department of Medicine Faculty Papers

Valemetostat tosylate (valemetostat) is an oral, potent, dual inhibitor of enhancer of zeste homolog (EZH)2/1, under investigation in non-Hodgkin lymphomas (NHLs) and solid tumors. In vitro, it inhibits cytochrome P450 3A (CYP3A) and P-glycoprotein (P-gp) when combined with sensitive CYP3A or P-gp substrates. This drug–drug interaction (DDI) sub-study is part of the phase 1 trial of valemetostat monotherapy (DS3201-A-J101; NCT02732275), assessing the effect of valemetostat on the pharmacokinetics (PK) of sensitive CYP3A and P-gp substrates midazolam and digoxin, respectively, in patients with relapsed or refractory NHL, and its safety and efficacy. Patients received two simultaneous single doses of midazolam and …


Impact Of Transplant Conditioning, Npm1 Mutations, And Measurable Residual Disease In Flt3-Itd Acute Myeloid Leukemia, Mark J Levis, Geoffrey L Uy, Et Al. Oct 2025

Impact Of Transplant Conditioning, Npm1 Mutations, And Measurable Residual Disease In Flt3-Itd Acute Myeloid Leukemia, Mark J Levis, Geoffrey L Uy, Et Al.

2020-Current year OA Pubs

We conducted a post hoc analysis of data from Blood and Marrow Transplant Clinical Trials Network 1506 (MORPHO), a randomized trial of gilteritinib vs placebo as posttransplantation maintenance for patients with FLT3-ITD-mutated acute myeloid leukemia (AML) undergoing allogeneic hematopoietic cell transplantation (HCT), focusing the interactions between conditioning regimen intensity, measurable residual disease (MRD), and NPM1 comutation status reported from diagnosis. Comparing FLT3-ITD MRD before and after conditioning, there was no difference between myeloablative conditioning (MAC) and reduced-intensity conditioning (RIC) in eradication or reduction of FLT3-ITD MRD. For participants who were FLT3-ITD MRD negative before HCT, there was no difference in …


Screening For Trypanosoma Cruzi In Patients Living With The Human Immunodeficiency Virus (Pwh) In The Peruvian Amazon, Silvia Otero-Rodriguez, Martin Casapia-Morales, Lilia-Lorena Pinedo-Ramirez, Esperanza Merino, Eva H Clark, José-Manuel Ramos-Rincón Oct 2025

Screening For Trypanosoma Cruzi In Patients Living With The Human Immunodeficiency Virus (Pwh) In The Peruvian Amazon, Silvia Otero-Rodriguez, Martin Casapia-Morales, Lilia-Lorena Pinedo-Ramirez, Esperanza Merino, Eva H Clark, José-Manuel Ramos-Rincón

Faculty, Staff and Students Publications

Introduction: Chagas disease (CD) - Trypanosoma cruzi infection - in people living with HIV (PWH), particularly those with advanced CD4 T cell depletion, can lead to severe syndromes affecting the central nervous system and the heart.

Methods: We performed a cross-sectional study to screen for CD among PWH in Iquitos, Peru, between October 2023 and May 2024, with the objective of understanding the frequency of infection in this population. Adults with confirmed HIV attending outpatient services at two regional hospitals were enrolled. Two ELISA tests (lysate and recombinant) were used, and discordant results were adjudicated by indirect chemiluminescence immunoassay (CLIA). …


Molecular And Cellular Characterization Of Planarian Stem Cell Microenvironments, Frederick G Mann, Carolyn E Brewster, Dung M Vuu, Mol Mir, Riley Galton, Shao-Fu Nien, Enya R Dewars, Carlos Guerrero-Hernández, Jason A Morrison, Mary C Mckinney, Lucinda E Maddera, Melainia L Mcclain, Kate E Hall, Seth Malloy, Shiyuan Chen, Brian D Slaughter, Sean A Mckinney, Stephanie H Nowotarski, Anoja Perera, Blair W Benham-Pyle, Alejandro Sánchez Alvarado Oct 2025

Molecular And Cellular Characterization Of Planarian Stem Cell Microenvironments, Frederick G Mann, Carolyn E Brewster, Dung M Vuu, Mol Mir, Riley Galton, Shao-Fu Nien, Enya R Dewars, Carlos Guerrero-Hernández, Jason A Morrison, Mary C Mckinney, Lucinda E Maddera, Melainia L Mcclain, Kate E Hall, Seth Malloy, Shiyuan Chen, Brian D Slaughter, Sean A Mckinney, Stephanie H Nowotarski, Anoja Perera, Blair W Benham-Pyle, Alejandro Sánchez Alvarado

Faculty, Staff and Students Publications

Stem cell niches are essential for regulating stem cell self-renewal and differentiation during tissue repair and regeneration. However, the mechanisms supporting stem cell function in highly regenerative organisms, such as the freshwater planarian Schmidtea mediterranea, remain unclear. Using spatial transcriptomics, we identified two cell types associated with planarian stem cells: secretory cells we term "hecatonoblasts" and intestinal cells. Surprisingly, while hecatonoblasts were in close physical proximity to stem cells in the mesenchyme, they were dispensable for regeneration. In contrast, intestinal cells, despite lacking direct contact with stem cells, regulated both their position and function during regeneration. Electron microscopy revealed diverse …


Selective Rna Sequestration In Biomolecular Condensates Directs Cell Fate Transitions, Patrizia Pessina, Mika Nevo, Junchao Shi, Srikanth Kodali, Eduard Casas, Yingzhi Cui, Alicia L Richards, Emily J Park, Xi Chen, Florencia Levin-Ferreyra, Alejandra Rivera Tostado, Erica Stevenson, Nevan J Krogan, Danielle L Swaney, Qilong Ying, Qi Chen, Justin Brumbaugh, Bruno Di Stefano Oct 2025

Selective Rna Sequestration In Biomolecular Condensates Directs Cell Fate Transitions, Patrizia Pessina, Mika Nevo, Junchao Shi, Srikanth Kodali, Eduard Casas, Yingzhi Cui, Alicia L Richards, Emily J Park, Xi Chen, Florencia Levin-Ferreyra, Alejandra Rivera Tostado, Erica Stevenson, Nevan J Krogan, Danielle L Swaney, Qilong Ying, Qi Chen, Justin Brumbaugh, Bruno Di Stefano

Faculty, Staff and Students Publications

Controlling stem cell differentiation is a longstanding goal in biomedical research. Here we explore how cell fate is influenced by RNA condensates, specifically P-bodies, which modulate gene expression posttranscriptionally. We profiled the transcriptomes of biomolecular condensates in diverse developmental contexts spanning multiple vertebrate species. Our analyses revealed conserved, cell type-specific sequestration of untranslated RNAs encoding cell fate regulators. P-body RNA contents do not reflect active gene expression in each cell type but are enriched for translationally repressed transcripts characteristic of the preceding developmental stage. Mechanistically, P-body contents are controlled by microRNAs and can be profoundly reshaped by perturbing AGO2 or …


Factor Structure Of Food And Physical Activity Parenting Practices Among Us Fathers By Ethnicity And Survey Language: A Cross Sectional Study, Salma M A Musaad, Louise C Mâsse, Alicia Beltran, Oriana Perez, Teresia M O'Connor Oct 2025

Factor Structure Of Food And Physical Activity Parenting Practices Among Us Fathers By Ethnicity And Survey Language: A Cross Sectional Study, Salma M A Musaad, Louise C Mâsse, Alicia Beltran, Oriana Perez, Teresia M O'Connor

Children’s Nutrition Research Center Staff Publications

Background: Parenting practices contribute to children’s eating and physical activity behaviors, and thereby their risk of obesity and associated medical conditions. Fathers may engage in different parenting practices than mothers. The objective of this study was therefore to establish psychometrically sound tools in English and Spanish for measuring Physical Activity Parenting Practices (PAPP) and Food Parenting Practices (FPP) for Hispanic and non-Hispanic fathers of diverse races for use in future studies, such as evaluations of family-based obesity interventions targeted at fathers.

Methods: We conducted a preliminary assessment of the psychometric properties of a reduced version of the PAPP and FPP …