Digital Commons Network^™

Global, Regional, And National Burden Of Cardiovascular Diseases And Risk Factors In 204 Countries And Territories, 1990-2023, Global Burden Of Cardiovascular Diseases And Risks 2023 Collaborators, Benjamin A. Stark, Nicole K. Decleene, Emily C. Desai, Johnathan M. Hsu, Catherine O. Johnson, Laura Lara-Castor, Kate E. Legrand, Prof Bhoomadevi A, Mohammad Amin Aalipour, Hasan Aalruz, Bedru J. Abafita, Ukachukwu O. Abaraogu, Mohammad Abavisani, Nasir Abbas, Madineh Abbasi, Mohammadreza Abbasian, Hedayat Abbastabar, Abdallah H.A. Abd Al Magied, Samar Abd Elhafeez, Prof Ahmed Abdelalim, Omar M. Abdelfattah, Prof Reda Abdel-Hameed, Mahmoud Abdelnabi, Prof Wael M Abdel-Rahman, Parsa Abdi, Wakgari Mosisa Abdisa, Daba Abdissa, Arman Abdous, Mujahid Abdullah

Peninsula Medical School

Background: Cardiovascular diseases (CVDs) are the leading cause of mortality and are among the foremost causes of disability globally. CVD burden has continued to increase in most countries since 1990, with trends driven by changing exposures to harmful risk factors, population growth, and population aging. Objectives: We report estimates of global, national, and subnational CVD burden, including 18 subdiseases and 12 associated modifiable risk factors. We analyzed change in CVD burden from 1990 to 2023 and identified drivers of change including population growth, population aging, and risk factor exposure. Methods: The Global Burden of Disease (GBD) 2023 study, a multinational …

Hif-2-Dependent Regulation Of Pthrp And Paraneoplastic Hypercalcemia In Aggressive Clear-Cell Renal Cell Carcinoma, Arijit Mal, Bingqing Xie, Zane Gray, Charlotte Small, Susmita G Ramanand, Yunpeng Gao, Vanina Toffessi Tcheuyap, Sashi Debnath, Alana Christie, Jeffrey Miyata, Brooklyn Jackson, Hua Zhong, Boning Gao, Jay Lohrey, Naim M Maalouf, Sangeetha M Reddy, John D Minna, Ivan Pedrosa, Xiankai Sun, Ram S Mani, Payal Kapur, James Brugarolas

Faculty, Staff and Student Publications

Renal cell carcinoma (RCC) patients with hypercalcemia (HC) have worse outcomes. HC often involves PTHrP, and the role of HIF-2 is incompletely understood. Leveraging RCC tumorgraft (TG) models of HC, which were characterized by tumor cell autonomous inflamatory/immune signatures, we show that HIF-2 inhibition with PT2399 frequently normalized calcium, downregulated circulating PTHrP and reduced HIF-2 binding to the PTHLH (PTHrP) promoter. Likely contributing to the selective induction of PTHrP in a subset of HIF-2-dependent tumors, the PTHLH locus was generally more accessible in TG(HC). However, PTHLH chromatin accessibility was grossly unaffected by PT2399, unlike elsewhere (including EPO locus in a …

Public Priorities For The Post-War Reconstruction Of Ukraine’S Energy Sector., Olena Savchenko, Vasyl Zhelykh, Khrystyna Kozak, Omar Al-Hafith, Joao Alencastro, Olugbenga Oladinrin, Ademola Adebayo Akinbami

School of Art, Design and Architecture

The Russian invasion of Ukraine has resulted in the large-scale destruction of many cities across the country. Although the war has not yet ended, there will come a time when the conflict concludes, and reconstruction efforts will begin. Global experiences show that the first step in preparing for post-war reconstruction is to assess the level of destruction. Additionally, it is essential to understand people’s needs and priorities. Otherwise, reconstruction activities may fail to address the existing challenges and actual needs of local communities. This study aims to explore post-war reconstruction priorities of Ukrainians, with special focus on the energy sector …

Examining The Relationship Between School Location, Neighborhood Resources And Advancement Courses Offerings, Eudarius Jones

Electronic Theses and Dissertations Archive

This study addresses a critical gap in educational equity research by examining how neighborhood-level factors intersect to shape access to rigorous academic programming, a key gateway to postsecondary success. Integrating geospatial visualization and hierarchical linear modeling within a critical geography framework, the study investigates how structural inequalities—rooted in race, poverty, and place—influence advanced course-taking opportunities across the Memphis metropolitan region. Data sources included the U.S. Department of Education’s Common Core of Data (CCD) for district-level enrollment and school type, the U.S. Census and American Community Survey (ACS) for demographic and socioeconomic indicators, and the National Center for Charitable Statistics (NCCS) …

Inhibition Of Clostridioides Difficile-Specific Dna Adenine Methyltransferase Cama By Analogs Of S‑Adenosyl‑L‑Methionine, Jujun Zhou, Youchao Deng, Dan Yu, Taraneh Hajian, Masoud Vedadi, Xing Zhang, Robert M Blumenthal, Rong Huang, Xiaodong Cheng

Faculty, Staff and Student Publications

Epigenetically targeted therapies, especially those inhibiting S-adenosyl-l-methionine (SAM)-dependent methylations of DNA, mRNA, and histones, have advanced rapidly in cancer treatment. However, these therapies remain underexplored for antibiotic development, despite the growing threat of antimicrobial resistance. Here, we screened a focused library of SAM analogs against the DNA adenine methyltransferase CamA specific to the enteric pathogen Clostridioides difficile. At the same time, we examined six other adenine methyltransferases, including two bacterial DNA methyltransferases and four human RNA methyltransferases having distinct RNA substrates. Compound 113 selectively inhibited CamA (IC50 = 0.15 μM). In addition, compound 67 inhibited Caulobacter crescentus CcrM …

Christmas Calories And Hallmark Movies, Mark Volkers

Faculty Work Comprehensive List

"Christmas is a great time to indulge in a few sweets, while also enjoying hearty meals that give us strength for the new year to come."

Posting about ­­­­­­­­balancing seasonal comforts with faithful living from In All Things, an online hub that offers insight into maintaining and faithful and orthodox Reformed Christian worldview while fearlessly engaging in every aspect of contemporary life – until all is made new.

Christmas Calories and Hallmark Movies

Matthew Draper, Matthew Draper, Gus Guikema

Oral Histories of Farming along the Middle Rio Grande

No abstract provided.

Policy Design For Multiple Funding Flows Into Trump Accounts, Jin Huang, Michael Sherraden, Lissa Johnson

Center for Social Development Research

The law creating the new Trump Accounts explicitly authorizes employers to provide deposits matching contributions that their employees make to the accounts and also authorizes contributions by philanthropic organizations. Both features are essential for build­ing substantial lifetime assets for America’s children. Implementing them successfully – and ensuring that the funds reach every eligible child efficiently – will require an effective policy platform for routing, verifying, and reporting on third-party contributions. This brief discusses why traditional retail IRAs cannot support matching contributions and how to build a policy platform capable of accommodating multiple contribution streams.

Readability Analysis Of Aaos And Assh Shoulder And Elbow Patient Education Online Content: A 9-Year Follow-Up Study, Connor Parry, Teresa Veselack, Matthew Doscher, Bryan G. Beutel

Student Publications

Given the progressive spread of medical misinformation, access to understandable educational content from trusted sources has become increasingly more crucial for patients. Online patient education materials, particularly from specialty organizations, have been criticized for being too complex for the average reader. It is advised that this information be at or below the 6^th-grade reading level. This study is a 9-year follow-up to an analysis conducted in 2013 which evaluated the overall readability of educational articles from the American Academy of Orthopaedic Surgeons (AAOS) and American Society for Surgery of the Hand (ASSH) websites related to shoulder and elbow …

Extensions Of Weighted Integral Inequalities For Ga-Convex Functions In Connection With Fejér’S Result, Muhammad Amer Latif

Publications and Research

No abstract provided.

The Role Of Religion In Ensuring National Security In Kazakhstan, Nurzhan Arystanbekuly Tursin Nur, Mukhan Issakhan, Shamshadin Kerim, Kovalev Dmitriy, Kalimash Begalinova

Occasional Papers on Religion in Eastern Europe

This article explores the foundations of state policy aimed at ensuring religious stability in Kazakhstan. It analyzes the scientific basis of religious studies, principles of tolerance toward the country’s traditional religions, and the role of religion in maintaining national security. The methodology, goals, and objectives of the study are shaped by the interdisciplinary nature of the subject. The research examines state and interfaith relations, the development of freedom of religion, its integration into domestic and international law, and ways of resolving legal contradictions, traditions, and stereotypes. The theoretical framework relies on the works of domestic and foreign scholars devoted to …

Adventism In The Ukrainian Ssr During The Post-War Period (1946–1952): Structure, Activities, And Relations With The Authorities (A Case Study Of Vinnytsia Region)., Anatoliy A. Voynarovskiy Skiy

Occasional Papers on Religion in Eastern Europe

The article contributes to the study of Adventism as a Protestant movement and examines its structure, activities, and interactions with Soviet authorities in the Ukrainian SSR during the post-war period (1946–1952). Particular attention is paid to the organizational characteristics and functioning of the Seventh-day Adventist Church (hereinafter SDA), which, among Ukrainian SSR regions, had the largest number of adherents in Vinnytsia region. In the present-day context of Ukraine’s fight for sovereignty, formation of the national church, and protection of religious freedoms for all citizens, particular attention should be paid to understanding the role of religious institutions in the development of …

The Rhetorical Discourse Of Uniate Writers’ Polemic Literature Of The End Of The 16th – First Half Of The 17th Century In The Retrospection Of Oratory's History, Ruslan Tkachuk

Occasional Papers on Religion in Eastern Europe

The examination of the poetics inherent in the polemical prose authored by Uniate writers during the late 16th and the first half of the 17th centuries holds substantial significance for comprehending rhetoric as a pivotal element in the stylistic evolution of Ukrainian literature throughout this period. The objective of this article is to explore the interrelationship between the works of Uniate polemicists and the framework of classical rhetoric, particularly by elucidating the functioning of rhetorical figures and argumentation techniques within their texts. To accomplish this aim, a range of literary methodologies were employed. Those methods included historical-cultural, comparative-historical, biographical, structural-analytical, …

The Legal Position Of The Religious Communities In The Republic Of Macedonia, Jovan Jonovski

Occasional Papers on Religion in Eastern Europe

The territory of the modern Republic of Macedonia (official name as of recently is Republic of North Macedonia) has historically been exposed to Judaism, Eastern and Western Christianity, Islam, and later to Protestantism. In the People’s /Socialist Republic of Macedonia, the religious communities were kept out of public life and suppressed. The government favored the Macedonian Orthodox Church for strengthening the Macedonian national consciousness. The Republic of Macedonia is a self-declared secular multi-confessional state. The article covers the history of the religious landscape as well as the legal framework and practices of the state toward the Churches, faith communities, and …

Religious Communication In Ukraine's Media Space As Factor In The Formation Of Confessional Identity, Oleh Sokolovskyi, Dmytro Garaschuk

Occasional Papers on Religion in Eastern Europe

This article presents a comprehensive study within religious studies of religious periodicals in Ukraine from the early 1990s to the present. It attempts to analyze the dynamics of the emergence and transformation of printed religious mass media in the context of the democratization of social life, changes in the information environment, and the development of civil society. It is noted that religious periodicals occupy a special place within the media landscape, since they perform not only the function of conveying information but also tasks of catechesis, spiritual-educational ministry, the formation of value orientations, and the preservation of cultural-historical heritage.

The …

Religion And Human Rights In The Realities Of The Russian-Ukrainian War, Andrii Marchenko

Occasional Papers on Religion in Eastern Europe

The article is devoted to the peculiarities of the relationship between religion and human rights in the context of the Russian-Ukrainian war. It is noted that Russia’s expansion results in a decrease in religious freedom in the temporarily occupied lands, a narrowing of the scope of this fundamental norm. At the same time, the author emphasizes not only the violations of the rights and freedoms of believers in the temporarily occupied territories of the country caused by external factors, but also some internal problems of the socio-religious life of modern Ukraine.The article analyzes the actions of the Ukrainian authorities to …

Orthodoxy, Culture And Language: Alaska In Russia’S Religious Diplomacy Of The 21st Century, Oleksandr Lukyanenko

Occasional Papers on Religion in Eastern Europe

The article is devoted to the analysis of the religious factor of the Russian foreign diplomacy in the light of Vladimir Putin’s high-profile visit to Alaska n August 15, 2025. The paper studies a special place of Alaska in the historical imagination of Russian political and church discourse. The status of this particular territory in Russian state worldview – the former “Russian America” – is indicative: it refers to the idea of an unfinished imperial legacy. The research doesn’t touch a main event that included a meeting with US President Donald Trump but an off-schedule meeting with Archbishop Alexei (Trader) …

Frontmatter (Volume 45, Issue 10), Paul B. Mojzes

Occasional Papers on Religion in Eastern Europe

No abstract provided.

Protests, Epistemic Injustice, And The Movement For Black Lives, Sofia De Ferrari

PSU McNair Scholars Online Journal

Epistemic injustice provides a powerful perspective for understanding media narratives of the Movement for Black Lives (#BlackLivesMatter). To understand the media coverage, I draw on Foucauldian theories and critical race theory, as well as accounts of hermeneutical and recognition injustice, which show how “truth” emerges as a product of knowledge/power/resistance. Special attention is given to the question of violence: what is violent and what isn’t? Who gets to decide? What are the consequences? Media narratives favor the status quo and delegitimize social movements which challenge it. This is achieved by prioritizing the voices of officials and law enforcement in coverage …

Grendel's Mother Talks Back: Contemporary Women's Mythopoeic Revisions, Anna Smol

Mythopoeic Society Seminar Proceedings

"Grendel's Mother Talks Back: Contemporary Women's Mythopoeic Revisions" examines how twenty-first-century feminist adaptations and translations examine the significance and point of view of Grendel's Mother, a character from the Old English poem Beowulf. In contrast to past views of Beowulf, especially in J.R.R. Tolkien's influential essay on the poem, these women writers and scholars argue for the central role of Grendel's Mother and give voice to her story. The paper discusses the main features of these adaptations, covering topics of narrative voice, borderlands, violence, and motherhood, and generally questions the concept of monstrosity as applied to Grendel's Mother. The paper …

Still Perilous, Still Fair: Perspectives On The Legacy, Or How (Not)Eowyn And (Not)Galadriel Made The Magic Work, Janet Croft, Leslie Donovan

Mythopoeic Society Seminar Proceedings

An informal and wide-ranging conversation between the co-editors of Perilous and Fair: Women in the Works and Life of J.R.R. Tolkien will cover the genesis and development of the project and the pitfalls and traps for the unwary we encountered along the way. We'll talk about the technicalities of our process as editors -- from developing the call for papers through choosing the cover art. And we'll assess the influence the collection has had on subsequent scholarship, and the continuing significance of some of the work included.

More Perilous And Fair, Cami Agan, Clare Moore, Robin A. Reid Dr.

Mythopoeic Society Seminar Proceedings

An overview of the conference's theme and speakers.

Book Review: Ecologies Of Inequity. How Disaster Response Reconstitutes Race And Class Inequality, Abel Traslaviña-Arias

Critical Disaster Studies

In Ecologies of Inequity: How Disaster Response Reconstitutes Race and Class Inequality, Sancha Doxilly Medwinter gathered diverse stories about how various migrant communities had to overcome not only disaster but also the overlapping networks established by those who were supposed to support them in 2012 in New York City. Medwinter portrays this contested post-disaster landscape through a thorough data recording of 120 individuals affiliated with various groups: racialized migrants or locals, tenants or property owners, local or external helpers, and those from wealthy or impoverished backgrounds. Ecologies of Inequity refer to the spatialized networks of organizational and interpersonal relations …

Upper-Body Post-Activation Performance Enhancement In Mma Athletes: Load-Dependent Effects Across Multiple Explosive Tasks, Jan Strawiński, Dariusz T. Skalski, Magdalena Prończuk, Kinga Łosińska, Ewelina Lulińska, Miłosz Drozd, Maciej Kostrzewa, Adam Maszczyk, Robert K. Roczniok

Baltic Journal of Health and Physical Activity

Background: Post-activation performance enhancement (PAPE) has become a recognized method for acutely improving explosive output, particularly relevant to upper-body performance in combat sports. Objective: This study aimed to evaluate the effects of bench press conditioning activities (CAs) at different intensities (50 %, 65 %, and 80 % 1RM) on upper-body explosive performance in mixed martial arts (MMA) athletes, with emphasis on training status. Methods: Twenty-nine male MMA athletes were divided into intermediate (n = 14) and advanced (n = 15) groups. Each participant completed three CA sessions followed by a 4-minute recovery and then performed a plyometric push-up …

Evaluating Kansai Airport's Ppp: Grounded Ambitions, Concession Of Financial, Geotechnical, And Climate Risk, Edmund Cho, Dimitrios V. Siskos

International Journal of Aviation, Aeronautics, and Aerospace

This study critically examines the Kansai Airports Group’s 44-year Public-Private Partnership (PPP) monopoly-type concession encompassing Kansai International (KIX), Osaka Itami (ITM), and Kobe (UKB) airports. The research uses financial analysis, Monte Carlo simulation, and NPV-at-risk modeling to evaluate how Japan’s fixed-term private monopoly model allocates financial, operational, and environmental risks. In 2015, there were significant developments in the promotion of the Private Finance Initiative (PFI) Act. It was revised in 2015; as a result, it finds that the underestimated long-term maintenance liabilities, especially Kansai airport (KIX) foundation subsidence, and lacked flexibility to manage exogenous shocks like COVID-19 and Typhoon Jebi. …

Rogue Access Points And Their Impact On Networks, Sami Belmokhtar

Cybersecurity Undergraduate Research Showcase

This paper focuses on rogue access points (rogue APs) and how they can impact the security and stability of a network, and consequently, the safety and privacy of the users. Wireless access points (WAPs) are nodes that allow a user to connect to a local network. This includes devices such as the routers typically used in a home network. This paper examines how an unauthorized WAP may pose a threat to a network in both a public environment and an enterprise environment. Furthermore, it shows how a hacker can mimic a real wireless network and gain access to both user …

A Transition Framework For Hybrid Tls In Enterprise-Level Systems, William Hadd

Cybersecurity Undergraduate Research Showcase

Enterprises face an immediate need to protect long-lived data against harvest-now, decrypt-later threats while maintaining interoperability across layered systems. With NIST’s first post-quantum standards finalized (ML-KEM, ML-DSA, SLH-DSA) and TLS hybridization drafts defining concrete ECDHE + ML-KEM groups, adoption can begin at the TLS termination layer even before full ecosystem support for post-quantum signatures arrives (NIST, 2024; IETF, 2025). In this paper, we propose an enterprise-oriented transition framework and maturity model for hybrid TLS across email, internal API gateways, and object storage. We specify where to enforce, which hybrid groups to select, and how to prevent silent downgrade with policy …

The Legal And Ethical Impacts Of Cybersecurity Practices On Privacy And Digital Rights, Ibrahim Fejzulla

Cybersecurity Undergraduate Research Showcase

The General Data Protection Regulation (GDPR) and the Health Insurance Portability and Accountability Act (HIPAA) are meant to secure our data, but sometimes it feels as if organizations don’t do enough to secure and protect our data and privacy. Even some of the things organizations may do to improve security may sound counterintuitive like hiring ethical hackers or penetration testers. This research looks at the effects both, the GDPR and HIPAA, have had on cybersecurity practices and policies of organizations. This paper aims to analyze the effects of both the GDPR and HIPAA, answer whether ethical hacking is justified, analyze …

Taking A Trip Into Nature’S Medicine Cabinet: A Country Comparison Of Efforts To Reschedule Psilocybin And Mdma For Therapeutic Use, Ariyah Jones

Georgia Journal of International & Comparative Law

No abstract provided.

A Comparison Between American And Hong Konger Regulatory Efforts Of Cryptocurrency Exchanges In The Light Of The Bankruptcy Of Ftx Trading Ltd., Patrick Johnson

Georgia Journal of International & Comparative Law

No abstract provided.