Digital Commons Network^™

A Case Report Of Myocardial Infarction Complicated With Blood Pressure Fluctuations Caused By Pheochromocytoma, Huiping Li, Wei Yang, Yu Feng, You Zhang, Gan-Xin Yan, Chuanyu Gao

Department of Medicine Faculty Papers

Pheochromocytoma typically presents with sustained or paroxysmal hypertension, but initial manifestation as acute non-ST-segment elevation myocardial infarction (NSTEMI) is rare. Peri-procedural hemodynamic fluctuations are often dramatic, making diagnosis and management challenging. We report a 51-year-old male admitted with chest tightness for 17 days. Elevated troponin and coronary angiography showing multivessel disease with total occlusion of the mid-left anterior descending artery (LAD) led to a preliminary diagnosis of NSTEMI. During percutaneous coronary intervention, blood pressure surged to 240/130 mmHg; intravenous nitroprusside caused an instantaneous drop to 95/55 mmHg, with rapid rebound to >200 mmHg upon withdrawal, showing no clear temporal relationship …

Translational Reading Frame Predicts The Pathogenicity Of C-Terminal Frameshift Deletions In Mecp2, Jacky Guy, Elena Hein, Beatrice Alexander-Howden, Timur Von Bock Und Polach, Tricia Mathieson, Benjamin P Kleinstiver, Huda Y Zoghbi, Adrian Bird

Duncan NRI Faculty and Staff Publications

Mutations in the MECP2 gene cause the severe neurological disorder Rett syndrome. A cluster of frameshift-causing C-terminal deletions (CTDs) removes ~100 amino acids and accounts for approximately 10% of RTT-causing mutations. Their pathogenicity is unexpected because this C-terminal domain is dispensable in mice. Analysis of pathogenic and benign human MECP2 variants reveals that some individuals with apparently typical CTDs do not develop Rett syndrome, confirming that C-terminal truncations are not intrinsically pathogenic. Using human sequence data and mouse models we show that pathogenicity results from a marked reduction in MeCP2 levels and depends on the presence of a proline proline …

The Measured Toll: Visualizing The Hidden Impact Of Chronic Painkiller Use, Yun Chia (Lisa) Song

Theses

The Measured Toll: Visualizing the Hidden Impact of Chronic Painkiller Use investigates how clinical data can be reinterpreted through the lens of information design to reveal long-term effects on heart and liver health that are often overlooked or invisible. This project translates complex medical information into a visual language that prioritizes clarity, emotional resonance, and user engagement. Through a series of printed posters and a motion-based introduction, the work employs abstract design strategies—including subtle distortion, radial line structures, and restrained typography—to evoke a sense of internal tension and gradual change. By structuring the visuals to unfold as a narrative, the …

Functionality Risk Assessment And Risk-Based Management For Critical Infrastructure Systems, Anteneh Zewdu Deriba

Dissertations and Theses

Critical infrastructure systems such as transportation networks serve as the lifelines of modern society, supporting economic activity and ensuring access to critical services. Their disruption under extreme events can produce consequences extending far beyond physical damage to individual assets. In transportation networks for instance, failures of critical assets such as bridges and tunnels can reduce accessibility of communities, limit freight capabilities for commerce, and increase travel distance and travel time of road users. These consequences associated with the system functionality loss are tied not only to the physical vulnerability and failure of individual assets, but also to the system configuration …

How We Benefit From Job Satisfaction: The Moderating Effect Of Informal Caregiving On The Associations Between Job Satisfaction And Physiological And Psychological Stress, Jensine Paoletti-Hatcher, Vincent D. Lai, Christopher P. Fagundes

Psychology Faculty Publications and Presentations

Job satisfaction and the resource-building processes it supports may have meaningful implications for health and well-being. These processes may work differently for employees who have informal (i.e., unpaid) caregiving duties outside of work. Guided by conservation of resources theory, we examined two indirect stress-buffering pathways in a sample of 799 nursing home workers, measured four times over 18 months. We tested how job satisfaction affects gain strengthening (via higher positive spillover) and loss weakening (via lower work-family conflict), how these processes impact indices of physiological (i.e., C-reactive protein) and psychological (i.e., perceived) stress, and how informal caregiving status may moderate …

Cigarette Smoke Induces Fasn-Dependent Fatty Acid Metabolic Rewiring To Drive Bladder Cancer Progression, Chandra Sekhar Amara, Danthasinghe Waduge Badrajee Piyarathna, Abu Hena Mostafa Kamal, Yuen San Chan, Karthik Reddy Kami Reddy, Chandra Shekar R Ambati, Mohammed Khurshidul Hassan, Pratik Shriwas, Tanmay Gandhi, Antrix Jain, Tanja Gangnus, Pooja Popli, Roshan Borkar, Sung Wook Kang, Silvia L Summers, Vasanta Putluri, Sandra L Grimm, Sharan Venkatesh, Ningxin Song, Erin H Seeley, Jenna Hedlich-Dwyer, Shu-Hsia Chen, Nupam P Mahajan, Abhinav K Jain, Lacey Elizabeth Dobrolecki, Gabrielle A Wells, Hugo Villanueva, Jenny Li, Xuefeng Liu, Roni J Bollag, Anna Malovannaya, Sung Yun Jung, Hyun-Sung Lee, Irfan A Asangani, Martha K Terris, Chad J Creighton, Leomar Y Ballester, Balasubramanyam Karanam, Suyu Liu, Minjae Lee, Rajeeva R Raju, M Minhaj Siddiqui, Livia S Eberlin, Ramakrishna Kommagani, Arun Sreekumar, Jianjun Gao, Nicolas L Young, H Courtney Hodges, Cristian Coarfa, Natalie R Gassman, Seth P Lerner, Yair Lotan, Nagireddy Putluri

Faculty, Staff and Students Publications

Cigarette smoke promotes bladder tumor growth by enhancing cancer cell survival and proliferation through smoke mediated carcinogens. FASN, a key enzyme in fatty acid synthesis, is dysregulated in many cancers and correlates with aggressive phenotypes. In this study, we demonstrate elevated fatty acid levels and FASN specifically in smokers with bladder cancer. Elevated FASN under smoke exposure imparted epigenetic alterations, particularly histone acetylation, impacts DNA repair and DNA-binding transcription factors which regulate metabolic pathways. Under cigarette smoke, bladder cancer cells undergo a metabolic shift, utilizing glutamine as a major carbon source through reductive carboxylation to fuel fatty acid biosynthesis via …

Frequency And Outcome Of Peg Tube Implantations In Hospitalized Parkinson's Disease Patients, Rachael M. Burke, Ruina He, Hikaru Kamo, Tejas R. Mehta, Anne Brooks, Adrianne Smiley, Michael S. Okun, Christopher W. Hess, Matthew A. Remz

Department of Neurology Faculty Papers

BACKGROUND: Dysphagia is a known complication of Parkinson's Disease (PD). Percutaneous endoscopic gastrostomy (PEG) tube placement is a therapy for select patients with dysphagia. There is a paucity of information on the role of PEG in PD management.

OBJECTIVES: To investigate the frequency and outcomes of PEG tube implantations in hospitalized patients with PD.

METHODS: We performed a retrospective review of the PINC AI™ Healthcare Database of hospitalized PD patients between 2017 and 2023. PEG implantation, discharge status, and aspiration pneumonia (AP) diagnoses were collected and analyzed. The relationships between AP and PEG were evaluated using logistic regression. Generalized estimating …

Measuring The Tokenization Premium: A Cost Audit For Underserved Language Communities, Avijit Roy, Proma Roy, Hrishitva Patel

Publications and Research

Large language models are increasingly deployed as general-purpose educational and technical assistance systems, but their basic infrastructure does not treat languages equally. One underexamined source of disparity is tokenization: semantically equivalent content can require substantially different token counts across languages, affecting API cost, latency, and usable context length before a model is even invoked. We introduce the Tokenization Equity Audit (TEA), a reproducible benchmark for measuring tokenization premiums in technical tutoring content. TEA evaluates three widely used tokenizers, GPT-4o’s o200k base, Qwen2.5-7B, and Mistral-7B, on a 120-item Python debugging corpus translated from English into Bengali, Hindi, Arabic, Tamil, and Yoruba. …

Corruption In The Service Of The Common Good: The Legitimation Of Traditional Practitioners In Cameroon, Victorine Oyane Ossah

Journal of Law and Public Policy

This article shows how health law and public policy, in seeking to regulate traditional medicine, without fully recognising it, paradoxically end up producing the very social conditions for the corruption that they are supposed to combat. The aim is to identify, based on the experience of traditional healers, the various factors that contribute to establishing corruption not as a moral choice, but as a pragmatic strategy for preserving their knowledge, resources, and place in the healthcare system. The analysis presented is based on a qualitative survey of 30 traditional medicine practitioners in Yaoundé and Douala between 2021 and 2026, in …

Cardinal Vices In Middle-Earth (2025), By Martina Juričková, John Wm. Houghton

Journal of Tolkien Research

Book review, by John Wm. Houghton, of Cardinal Vices in Middle-earth (2025), by Martina Juričková.

First Insular Record And Dna Barcoding Of Euscorpius Vailatii Tropea & Fet, 2015 From Trizonia Island (Fokida, Greece), Konstantinos Kalaentzis, Francesco Frigioni, Alexios Panagiotopoulos, Elias Tzoras, Styliani Minoudi, Alexandros Triantafyllidis

Euscorpius

Euscorpius vailatii Tropea & Fet, 2015 (Scorpiones: Euscorpiidae), originally described from Aitoloakarnania and Fokida (Greece), is herein reported from Trizonia Island in the Gulf of Corinth, representing the first insular record for the species. The examined specimens are consistent with the diagnostic morphology of E. vailatii. The first molecular data for the species are provided, based on both mainland and insular populations. Comparative analyses further highlight the distinctiveness of E. vailatii from geographically close congeners, while phylogenetic results indicate a sister-taxon relationship with E. erymanthius, supporting a Quaternary biogeographic history shaped by the evolution of the Gulf of …

Staged Bilateral Magnetic Resonance‐Guided Focused Ultrasound For Treating Essential Tremor: Systematic Review And Meta‐Analysis, Nima Norbu Sherpa, Andrea Gonzalez Lezana, Gabriela Prilip, Kenji Fukutome, Nathan J. Pertsch, Ruth Reeve, Nadège Bault, Elsa Fouragnan

School of Psychology

BackgroundUnilateral magnetic resonance guided focused ultrasound (MRgFUS) thalamotomy reduces tremor in essential tremor, yet disability often persists on the untreated side. The added benefit and safety of a staged contralateral lesion remain uncertain.ObjectiveThe aim was to evaluate the efficacy and safety of staged bilateral MRgFUS thalamotomy for essential tremor.MethodsWe searched MEDLINE, EMBASE, Web of Science, Cochrane CENTRAL, Scopus, ClinicalTrials.gov, and World Health Organization International Clinical Trials Registry Platform from inception to April 12, 2026 (PROSPERO CRD420251027624). Eligible studies were staged bilateral MRgFUS with Clinical Rating Scale for Tremor outcomes and adverse events, and at least 3 months of follow up. …

Curious Minds, Critical Thinkers: Contextualization-Based Instruction In Secondary Social Studies, Kelcie J. Mashburn

Masters Projects

Research shows that many secondary students lack the critical thinking skills necessary for academic and civic success. Traditional instructional methods that prioritize content coverage and recall fail to help students develop and apply this skill. Effective instruction requires educators to move beyond these traditional methods and intentionally design curriculum that incorporates instructional strategies that engage students in analysis, investigation of diverse perspectives, and formulate evidence-based conclusions. This project addresses this gap by presenting a contextualization-based curriculum unit designed to support and build critical thinking skills among secondary Social Studies students. The result is a unit that immerses secondary Social Studies …

Reduction Of Length Of Stay For Total Joint Replacement Patients, Melody C. Golden

Master's Projects and Capstones

Abstract

Problem: Prolonged LOS in the PACU for patients undergoing total joint replacement surgery contributes to inefficiencies in patient flow, delayed throughput, and increased resource utilization. At Hospital A, recent LOS averages exceed internal and regional benchmarks, indicating a need for process improvement.

Context: The PACU is a high-volume, fast-paced environment requiring coordination among nursing, physical therapy, anesthesia, and discharge planning teams. Variability in workflow, communication gaps, and inconsistent timing of key processes contribute to delays in discharge readiness.

Interventions: From May through July 31^st, 2026, a quality improvement project was implemented using the Baldrige Excellence …

Evaluating The Effectiveness Of Upward Health’S Community-Based Care Model In San Mateo County, Emma Hunt

Master's Projects and Capstones

Program Overview

This evaluation examines the Upward Health program, a multidisciplinary, community-based care model that partners with Health Plan of San Mateo (HPSM) to provide comprehensive healthcare services for high-risk Medicare and Medi-Cal beneficiaries in San Mateo County, California. The program serves adults with multiple chronic conditions, behavioral health needs, frequent emergency department (ED) utilization, and significant social determinants of health (SDOH) challenges. Through an interdisciplinary team that includes Community Health Workers (CHWs), Nurse Practitioners, Registered Nurses, Licensed Clinical Social Workers, physicians, and Mental Health Nurse Practitioners, Upward Health delivers in-home, tele-health, and community-based services designed to improve access to …

Robustness Assessment Of Head And Neck Proton Therapy Plans Using Composite Synthetic Cts: A Preliminary Step Toward Ai Driven Anatomy Prediction Planning: A Retrospective Dosimetric Study., Ryan Michael Rodriguez

Masters Projects

Proton therapy is more commonly being utilized for head and neck cancer treatment due to its ability to reduce dose to the surrounding normal tissue. However, one of the biggest challenges in proton treatment is its sensitivity to changes in tissue density, often necessitating adaptive replanning. This study evaluated if incorporating additional synthetic CTs (sCT) datasets during robust optimization can create treatment plans that maintain target coverage and organ sparing despite anatomical changes better than the original nominal plan, thereby reducing the need for adaptive planning in head and neck proton treatment. Ten head and neck cancer patients who underwent …

The Role Of Parents In Supporting Student Learning At Home, Lindsey M. Deblaay

Masters Projects

This study addresses the pedagogical disconnect between modern, inquiry-based mathematics instruction and traditional caregiver support structures. While caregiver involvement has proved to be helpful in student achievement, systematic barriers that limit family’s capacity, parent self-efficacy and their willingness to use learning strategies at home, the perception of the parent role of caregivers in their child’ s education makes it difficult. The curriculum prioritizes conceptual number sense and critical thinking rather than rote standard algorithm, so it has created a barrier in parent support among caregivers with these instructional shifts. It diminishes parent self-efficacy particularly in fifth grade. The project features …

Bridging Fiscal Sustainability And Health Equity: A Policy Analysis Of California’S Healthcare Coverage Safeguards, Guadalupe Castaneda Martinez

Master's Projects and Capstones

Without structural policy intervention, approximately 4.6 million Californians remain at risk of being uninsured by 2030, worsening racial and ethnic health disparities and hospital uncompensated care burdens. This policy analysis advocates for a hybrid universal coverage model combining sliding-scale subsidies (California Senate Bill 78) with full-scope Medi-Cal expansion for all income-eligible residents regardless of legal status (California Assembly Bill 133). The framework relies on existing funding mechanisms, including the Managed Care Organization tax and the Health Care Affordability Reserve Fund. Comparative analysis indicates that market-only subsidies leave severe equity gaps, whereas immediate single-payer transitions pose substantial fiscal and administrative risks. …

Under The Surface: A Rare Case Of The En Coup De Sabre Subtype Of Linear Morphea In The Rio Grande Valley, Miguel Lopez, Jared Hensley, Maria Villegas

School of Medicine Publications

Localized scleroderma, also referred to as 'morphea,' is a rare autoimmune disorder that affects the superficial layers of the skin and is characterized by both erythematous and bruise-like lesions with signs of central skin tightening or sclerosis; deeper lesions may be identified as edematous, erythematous plaques in the absence of well-defined borders. A subtype named en coup de sabre (ECDS) exists in the classification of linear morphea and presents with a linear induration on either the face or scalp. Our patient is a 21-year-old Hispanic female initially residing outside of the South Texas region who experienced an onset of skin …

Moss Biomonitoring And Isotopic Signatures Reveal Aviation Fuel As Local Lead Source Near Oregon Airports, Oluwaseyi E. Aderinboye, Alyssa E. Shiel, Lauren Stalford, Christina J. Murphy, Dean B. Atkinson

Chemistry Faculty Publications and Presentations

Lead emissions from piston-engine aircraft using leaded aviation gasoline (avgas) remain a significant source of environmental contamination near regional airports, posing potential health risks to nearby communities. Passive biomonitoring using the epiphytic moss Orthotrichum lyellii was combined with lead isotope fingerprinting to quantify lead concentrations and distinguish between legacy leaded gasoline and current avgas emissions near Hillsboro and Troutdale airports in Oregon. Here we show that lead levels are elevated by up to 50 times the rural background near airports, with isotopic signatures confirming avgas as a dominant local source. These findings indicate that avgas use contributes substantially to environmental …

Anatomiya Ng Karinderya: An Exploration On The Reflected Filipino Cultural Values On The Visual Identity Of Carinderias In Cavite, Dan Gabriel V. Bagadiong, Ellaine Marie L. De Castro, Miriam Joan C. Generoso, Ej Jimenez, Fernando R. Lacson

DLSU Arts Congress Conference Proceedings

This study explored Filipino cultural values reflected in the visual identity of carinderias and examined their sociocultural and psychological significance within Filipino society. Known for serving lutong bahay (home-cooked meals), carinderias have long been embedded in Filipino culture, embodying values such as bayanihan (community spirit), kapwa (shared identity), and resilience while fostering community connections through food. Grounded in the framework of Pantayong Pananaw, the study investigated how these cultural and psychological values shape the identity and perception of carinderias. Focusing on selected small carinderias in Cavite, the research analyzed their cultural relevance, visual identity, and sociopsychological dimensions. Findings revealed …

Information Resources Utilization, Organisational Culture And Motivation As Determinants Of Quality Service Delivery Of Researchers In Nigerian Institute For Trypanosomiasis Research, Kaduna State, Nigeria., Alegbeleye Gabriel Olubunmi, Ibrahim Awodi, Yemisi Tomilola Babalola

Library Philosophy and Practice (e-journal)

This study investigated the combined influence of information resources utilization, organizational culture, and motivation on quality service delivery in the Nigerian Institute for Trypanosomiasis Research (NITR), Kaduna State. The population comprised 206 researchers across the six research departments of NITR, and a total enumeration technique was employed to include all the researchers. Using a structured questionnaire, 172 valid responses were obtained representing an 83.5% response rate. Data were analyzed using descriptive and multiple regression statistics. Anchored on Uses and Gratification Theory of Information behavior, the Denison Organizational Culture Model, and Self-Determination Theory, the findings revealed that the independent variables jointly …

Bibliometric Analysis Of The Top 100 Most Cited Publications From Saudi Arabia Reveals The Predominance Of Medical Fields, Mahmoud Kandeel, Abdulla Al-Taher

Saudi Medical Journal

Objectives: To explore the citation impact, journals, international collaborations, trends of research topics and gain more visibility for the Saudi contribution to the global scientific landscape. Methods: This bibliometric study analyzes the top 100 cited publications affiliated with Saudi Arabia in Scopus, from inception to January 2026. The extracted bibliometric indicators include total citation metrics, sources, collaboration maps, and co-occurrence networks of keywords and collaborations. Results: The results indicate a strong predominance for medicine and health sciences as the subjects of the most prolific and significant number of citations. A substantial proportion of the most cited papers originates from major …

Establishment Of A Specialized Pectus Clinic: Referral Patterns, Diagnostic Characteristics, And Early Management Experience At A University Hospital, Zeead M. Alghamdi

Saudi Medical Journal

Objectives: To describe the establishment and early impact of a dedicated pectus clinic at a university hospital, focusing on patient characteristics, referral pathways, clinical presentation, and initial management strategies. Methods: A retrospective observational study was conducted at a university hospital between January 2020 and April 2025, with 153 patients included in the final analysis. Data collected included demographic characteristics, referral sources, clinical presentation, deformity type, and treatment options. Descriptive statistical analysis was performed. Results: The mean patient age was 18.3 (range 1–44) years, with males accounting for 83.9% of cases. Pectus carinatum was the most common diagnosis (48.1%), followed by …

Patterns And Determinants Of Medication Errors Across The Medication-Use Process: A 3-Year Retrospective Study In A Saudi Tertiary Hospital, Nawaf S. Alqurashi, Mazen S. Alshehri, Mohammed J. Almalki, Mustafa M. Muradkhudhari, Rozan M. Radwan, Mohammed M. Aldurdunji, Saleh A. Almazam, Ohood K. Almuzaini, Saad M. Wali

Saudi Medical Journal

Objective: To characterize medication errors across the full workflow and identify stage-specific predictors in a tertiary care setting. Medication errors remain a major global patient safety concern, with limited comprehensive analyses across all stages of the medication-use process in Saudi Arabia. Methods: A retrospective observational study was conducted using medication error reports from Al-Noor Specialist Hospital, Makkah, between January 2023 and August 2025. Errors were classified by stage and severity using the National Coordinating Council for Medication Error Reporting and Prevention index. Multivariable logistic regression was performed to identify predictors associated with each stage. Results: A total of 6,546 errors …

Gender Differences In Primary Care Utilization And Determinants Of General Practitioner Visits Among Saudi Females: A Cross-Sectional Analysis Using World Health Survey In The Kingdom Of Saudi Arabia 2019, Ali M. Alzahrani, Holly C. Felix, Abdulrhman A. Alzhrani

Saudi Medical Journal

Objective: To document the number of visits Saudi adults have with general practitioners (GP) or family medicine doctors (FD), determine if there is an association between GP/FD visits and sex, and then identify factors associated with GP/FD visits among Saudi females. Methods: A cross-sectional analysis was conducted using data from the 2019 World Health Survey in the Kingdom of Saudi Arabia (KSAWHS 2019), a nationally representative household survey. The outcome variable was number of visits to GP/FD. Survey-weighted negative binomial regression was applied. Results: From April to July 2019, 8,912 individuals participated in the KSAWHS 2019 individual questionnaire, of whom …

Patient Experiences And Safety Concerns Regarding Glp-1 Receptor Agonists For Obesity: A Cross-Sectional Survey In Jeddah, Saudi Arabia, Mansour A Tobaiqy, Sulafa T. Alqutub, Mohammed A. Alzahrani, Renad H. Alazwari, Faisal A. Asiri

Saudi Medical Journal

Objective: To evaluate the perceptions, experiences, and safety concerns of patients regarding the glucagon-like peptide-1 (GLP-1) receptor agonists. Obesity is a significant public health issue. The newer anti-obesity medications: GLP-1 receptor agonists, with an increase in therapeutic options. However, little is known about the perceived benefits, safety, cost, and accessibility. Methods: Cross-sectional survey included adults who previously used at least 1 anti-obesity medication and conducted in 3 general hospitals in Jeddah, Kingdom of Saudi Arabia (KSA) during June 2025 to February 2026. The questionnaire was created after reviewing the current evidence and validated the contents. It included questions on demographic …

Patient Safety Culture Among Healthcare Professionals In Jeddah First Health Cluster: A Multi-Professional Cross-Sectional Study, Saad S. Alyazidi, Salah S. Alshagrawi

Saudi Medical Journal

Objective: Patient safety culture (PSC) is essential to improve healthcare quality and reduce preventable harm. Despite ongoing healthcare transformation in Saudi Arabia, there is limited evidence on healthcare professionals' (HCPs) perceptions of PSC in newly established health clusters. Methods: We conducted a cross-sectional study among HCPs in 6 government hospitals within the Jeddah First Health Cluster, Saudi Arabia. Data were gathered utilizing the Hospital Survey on PSC (HSOPSC). Descriptive measurement sand multiple linear regression analyses were used to evaluate perceptions of PSC and associated factors. Results: A total of 256 HCPs participated in the study. Overall, PSC was perceived as …

The Al-Bahah Paradox: Divergent Patterns Of Increased And Decreased Infectious Disease Incidence Relative To National Saudi Rates Over 12 Years Of Surveillance, Mohammed A. A. Alqumber

Saudi Medical Journal

Objective: To identify statistically significant deviations in notifiable infectious disease incidence between Al-Bahah region and national Saudi averages, and to generate hypotheses that may inform future epidemiological, microbiological, and public health investigations. Methods: In April 2026, a 12-year retrospective ecological study (2013–2024) was conducted using surveillance data from the Saudi Ministry of Health for 37 notifiable infectious diseases across 20 health regions. Cumulative incidence rates, standardized morbidity ratios (SMRs), and Z-tests compared observed cases in Al-Bahah against national estimates. Results: Overall incidence was 15.8% lower in Al-Bahah than nationally (86.42 versus 102.68; incidence rate ratios = 0.842; p …

Preoperative Urine Albumin-To-Creatinine Ratio Predicts Acute Kidney Injury After Coronary Artery Bypass Grafting, Ahmed M. Alkhunaizi, Jumana A. Al Naser, Khaled D. Algarni, Suhaib M. Ahmed, Amro M. Moubarak, Haralabos D. Parissis

Saudi Medical Journal

Objective: To prospectively evaluate whether baseline urine albumin-to-creatinine ratio (uACR) predicts acute kidney injury (AKI) and postoperative decline in kidney function in elective, isolated coronary artery bypass grafting (CABG) patients and explore the magnitude of effect across clinically relevant uACR strata. Preoperative uACR is a marker of glomerular endothelial dysfunction and systemic microvascular injury that may identify patients at increased risk for AKI after CABG. Methods: In this single-center prospective cohort study, 111 adults undergoing elective, isolated CABG between January 2020 and December 2024 were stratified by baseline uACR (< 30, 30–300, > 300 milligram/gram[mg/g]). The primary outcome was AKI defined by Kidney …