Digital Commons Network^™

Twas-Ctl: A Robust And Efficient Method For Multi-Tissue Transcriptome-Wide Association Studies Using Cross-Tissue Learners, Md Mutasim Billah, Hairong Wei, Fengzhu Sun, Kui Zhang

Michigan Tech Publications

The advent of transcriptome-wide association studies (TWAS) has expanded the classical genome-wide association study (GWAS) framework by integrating gene expression with genetic variation to identify trait-associated variants. While multi-tissue TWAS approaches improve statistical power over single-tissue models, existing methods often lose information during result aggregation and require intensive computation. Here, we present TWAS-CTL (Cross-Tissue Learner), a novel framework that leverages heterogeneous gene expression across tissues by adaptively reweighting and optimizing multiple single-tissue learners. Simulations demonstrate that TWAS-CTL achieves higher statistical power than the leading method, UTMOST, while maintaining proper type I error control and reducing computational time by over half. …

Assessing The Gender Differences In Mental Health Access And The Intersectionality Of Depression, Anxiety, Stress Between Black Men And Black Women During Covid-19, Turquoise Ef'e Pipes

Walden Dissertations and Doctoral Studies

The COVID-19 pandemic, which emerged in the past five years, has had a particularly severe impact on well-being, mental health, and access to care for Black communities. Therefore, the purpose of this quantitative study, grounded in intersectionality theory was to assess gender differences between Black women and Black men confronted with depression, anxiety, stress symptoms and mental health access during the crisis of COVID-19, which has been under researched within this demographic. The study sample included participants from various cities across the United States who lived through the COVID-19 pandemic from March 2020 to March 2023 (n= 104). A MANOVA …

Virtually Present In The Vastness: Vr’S Pathway To Awe And Appreciation, David Paul Peters

Dissertations - ALL

This dissertation explores how spatial presence in Virtual Reality (VR) creates awe and appreciation through the role of perceived vastness. 92 participants played a custom-built VR game (VR Nature Photographer) in three environments designed to be low, medium, and high in vastness. A repeated-measures design measured spatial presence, vastness, awe, and appreciation across conditions. Results showed higher vastness increased all four outcomes, with awe and vastness having the largest effect sizes and presence and appreciation medium sized. Mediation analyses showed perceived vastness fully mediated the effect of spatial presence on awe in all vastness conditions and partially mediated its effect …

Building Bridges: Industrial Trade Unions In A Changing Climate, Nicole Möller

Dissertations - ALL

This dissertation examines how German industrial trade unions and workers in the automobile and coal industries navigate the profound challenges of the green transition. Workers’ experiences are situated within a broader political-economic context shaped partly by market-led decarbonization efforts, welfare retrenchment/austerity, erosion of progressive institutions in society, and global competition, as well as a global restructuring of value accumulation. The analysis critically engages with unions’ current responses to a market-led transition and their implications for labor’s future. The dissertation develops its argument across three empirical chapters. Chapter 2 investigates workplace-level changes in coal mining and automobile production, analyzing how workers …

Effects Of Π-Rich Solvents And Nickel And Cobalt Dopants On The Synthesis And Properties Of Cesium Lead Halide Nanocrystals, Tsung-Hsing Chiang

Dissertations - ALL

Colloidal semiconductor nanocrystals feature unique properties like quantum confinement, tunable band gaps, and high surface-to-volume ratio; and have been proven as prominent materials in applications such as light-emitting diodes, sensors, lasers, solar cells, etc. Optoelectronic properties of semiconductor nanocrystals are highly associated with their sizes, morphologies, and compositions. Understanding the growth mechanism can lead to the ability to control the size, morphology, and composition of nanocrystals. In this thesis, growth and b-site doping of perovskite, cesium lead halide (CsPbX3), nanocrystals are discussed. Solvent effects in the growth of cesium lead bromide were first investigated from the aspect of plumbates in …

Robust Security Assurance In Cyber-Physical Systems: From Attack Diagnosis To Attack Resilience, Zifan Wang

Dissertations - ALL

Cyber-Physical Systems (CPS) have become integral to critical infrastructure, from autonomous vehicles to industrial control systems. However, their increased connectivity and sophistication introduce new vulnerabilities, making security a paramount concern. This dissertation presents a comprehensive pipeline for enhancing CPS security, focusing on accurate diagnosis of trustworthy time frames and subsystems, followed by system resilience measures to restore safe states. The foundation of system resilience lies in an advanced checkpointing protocol for real-time multi-process systems. A novel three-step approach uniquely addresses both logical and timing correctness, which are crucial for modern CPS applications. By partitioning processes into directed acyclic graphs, implementing …

Essays On Housing Choices, Neighborhood Quality, And Urban Blight, Samuel Saltmarsh

Dissertations - ALL

This dissertation contains two chapters related to housing choices of low-income families, neighborhood quality, and the remediation of urban blight. The first chapter examines the effectiveness of Detroit's 2014–2022 residential demolition program in addressing neighborhood blight and vacancy in a shrinking city context. Using a stylized model of durable housing with downward price frictions, I combine parcel-level data on vacancies, blight, and demolitions to estimate the causal effects of demolition exposure on vacancy rates for non-demolished, single-family homes. Employing a difference-in-differences design, I find that the program as a whole did not reduce vacancies, and instead slightly increased them by …

Using A Heuristic Tool To Improve Symptom Self-Management In Adolescents And Young Adults With Cancer: Protocol For A Randomized Controlled Trial., Suzanne Ameringer, Grace Hodges, R K Elswick, Lauri Linder, Catherine Fiona Macpherson, Kristin Stegenga

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Adolescents and young adults (AYAs) with cancer experience multiple distressing symptoms during treatment, yet few developmentally relevant resources have been developed to help them self-manage their symptoms. Empowering patients to have a more active role in self-management during cancer treatment may lessen their symptom severity and distress.

OBJECTIVE: The aim of this study is to test an intervention designed to improve symptom self-management, the Computerized Symptom Capture Tool (C-SCAT), by helping AYAs understand their unique symptom experience and discuss it with their health care providers.

METHODS: We are conducting a multisite, 2-group randomized controlled trial to evaluate the effects …

Feasibility Of Exercise And Mindfulness Intervention For Improving Psychological Symptoms In Female University Students With Smartphone Addiction: A Pilot Study, Huange Liu, Kim Geok Soh, Shamsulariffin Samsudin, Suriyan Somphong, Ranintya Meikahani, Nugroho Puji Santoso

Modern Sport

The prevalent use of smartphones has raised significant concerns regarding smartphone addiction among university students. This addiction can lead to a range of psychological problems, which may ultimately affect their academic performance and overall well-being. Engaging in exercise has been linked to improved mental well-being, mainly by regulating endorphin levels, which can help reduce feelings of anxiety and depression. Mindfulness-based interventions (MBIs) have become effective strategies for tackling different psychological challenges. Evidence indicates that mindfulness practices can significantly decrease stress, anxiety, and depression levels. Combining exercise with mindfulness (EM) techniques can boost their overall effectiveness and provide additional mental health …

Exploring The Chemical And Biological Foundations Of Protein Lipidation Through Functional And Computational Studies, Andrea Sprague-Getsy

Dissertations - ALL

Post-translational modifications (PTMs) are essential for the diversification of the human proteome. Prenylation is a PTM defined by the addition of a 15-carbon or 20 carbon isoprenoid group by FTase and GGTase-I, respectively, onto a cysteine near the C-terminus of proteins. This modification is the first step within the prenylation pathway where proteolysis and carboxymethylation occur afterwards, aiding in proteins localization to the cellular membrane. These prenyltransferases canonically recognize a “CaaX” box motif which has been determined through biochemical and structural studies. Recently, sequences following the C(x)3X and Cxx patterns have been shown to be prenylated as well as an …

On Detecting Change-Points Of A Segmented Logistic Regression Model, Jingwen Li

Dissertations - ALL

This dissertation investigates the problem of change-point detection in segmented logistic regression models, where the total number of change-points is unknown. We consider both unconstrained models, which allow discontinuities at change-points, and constrained models, which impose continuity across change-points. The central challenge is to determine the number of change-points and to accurately estimate their locations, while ensuring valid statistical inference for the associated regression coefficients. We begin by introducing a set of regularity assumptions that underlie the theoretical analysis throughout this work. For a given number of change-points, we present algorithms to estimate their locations and obtain the maximum likelihood …

Three Essays On The Supplemental Nutrition Assistance Program (Snap): Examining External Shocks, Protective Effects, And Administrative Challenges, Hyojeong Kim

Dissertations - ALL

Abstract In this dissertation, I present three studies that examine how different forms of inconsistency—arising from timing disruptions, eligibility structures, and administrative churn—shape the functioning and effectiveness of the Supplemental Nutrition Assistance Program (SNAP). Although SNAP is designed to provide a reliable source of food assistance, access to benefits is not always predictable, continuous, or evenly accessible. The studies show that inconsistencies can emerge through external shocks that alter the timing of benefit delivery, through eligibility rules tied to disability determinations in other programs that may exclude self-reported disabled households from accommodations, and through administrative procedures that generate temporary interruptions …

Mapping Research Trends On Mental Health Literacy Among University Students: A Bibliometric Systematic Review, Eko Pramudya Laksana, Muslihati Muslihati, Arbin Janu Setiyowati, Salsabila Kholifahtun Nisa, Muhammad Nur Hudha, Margaret Kehinde Soetan

Jurnal Kajian Bimbingan dan Konseling

Mental health is a global issue that has received increasing attention, particularly among university students. Mental health literacy (MHL) is an important factor in promoting students' psychological well-being through knowledge, attitudes, and the ability to recognize and address mental health problems. This study aims to map the developmental trends of MHL research among university students in order to provide a comprehensive overview of the direction and focus of studies in this field. This research employed a bibliometric literature review approach by analyzing 48 journal articles indexed in the Scopus database and published between 2021 and 2025. The findings indicate that …

Perceptions Of Lumbee Tribe Members On Participating In Diabetes Type Ii Prevention Practices, Jeremy Wesley Lowery

Walden Dissertations and Doctoral Studies

Type II diabetes (DB2) is one of the leading causes of death in the United States, whether directly or as a comorbidity. This is especially alarming for Native Americans, who have the highest DB2 prevalence and death rates when compared to their non-Native American peers. This qualitative phenomenological study explored the lived experiences of Lumbee Tribe members in Robeson County regarding DB2. The health belief model was used as a lens through which to understand and interpret findings. In-person semi-structured audio-recorded interviews were conducted with 12 participants recruited through social media. Data were coded and analyzed using deductive thematic analysis. …

Antifungal Activity Of Nutmeg Mace (Myristica Fragrans Houtt) Ethanol Extract Against Candida Spp., Muhammad Akbar Yandji, Eka Astuty, Fitri Kadarsih Bandjar

Folia Medica Indonesiana

Candida infections are increasingly common worldwide and represent one of the leading causes of death after cardiovascular disease. There are three types of candida that often infect humans, namely Candida albicans, Candida tropicalis and Candida parapsilosis. In the standard treatment used, immunity and side effects of treatment have been found. Therefore, other treatment options are needed, one of which is by using mace (Myristica fragrans Houtt) which is a native plant of Maluku and has secondary metabolite compounds that can be antifungal agents. This study aims to test the ability of ethanol extract of mace nutmeg ( …

Group Counseling Deactivation Mode To Improve Psychological Well-Being Of Students, Muya Barida, Dian Ari Widyastuti, Yuanita Dwi Krisphianti, Aslina Ahmad, Nurul Hidayati Rofiah, Andriyani Andriyani, Riana Mashar, Emiko Saraswaty

Jurnal Kajian Bimbingan dan Konseling

Life moves dynamically, profoundly impacting adolescents and often causing deep anxiety due to numerous pressures. The gap between expectations and reality frequently exacerbates this anxiety. Ideally, adolescents should be equipped to manage their inner lives to prevent excessive anxiety, and individuals can better manage anxiety if they possess strong psychological well-being. This study aims to improve psychological well-being through a group counseling deactivation mode. The research applied an experimental research method with a one group pretest-posttest design. Participants consisting of junior high school students in Yogyakarta, selected through purposive sampling for their low psychological well-being levels. Data on psychological well-being …

Online Counseling In Improving Achievement Motivation Over The Last Decade: A Bibliometric Review, Shopyan Jepri Kurniawan, Bambang Dibyo Wiyono, Mohd. Aziz Zulazmi

Jurnal Kajian Bimbingan dan Konseling

This research aims to determine online counseling research trends to increase achievement motivation. The method used in this research is bibliometric analysis using VOSviewer. The data used is the Scopus database for the last 10 years. Research findings found that there were 4302 documents that met the specified criteria. The number of online counseling studies increased gradually over the 2013-2022 research period. The largest source of documents comes from 3691 articles. Meanwhile, the annual distribution of 100 or more citations will be the highest in 2022 with 16. The keyword ``achievement motivation'' is not included in the top 10 keywords, …

Quantitative Evaluation Of Tunnel Rock Mass Integrity Based On Mwd Technology, Zhang Kunmu, Peng Hao, Liang Ming, Han Yu, Song Guanxian

Journal of China & Foreign Highway

In tunnel construction,the quantitative evaluation of rock mass integrity heavily relies on information from the exposed face,and there are challenges when drilling data is used for integrity evaluation.To this end,this study introduced a novel method for quantitative evaluation of rock mass integrity during drilling,integrating numerical statistics with machine learning.A substantial dataset of digital drilling data was collected,covering three common types of rock mass integrity:relatively intact,relatively fractured,and fractured.Subsequently,a high-performance random forest model for the classification of rock mass integrity was developed through data preprocessing and hyperparameter optimization.The interpretability of the model ’s predictive results was enhanced using Shapley additive explanations (SHAP …

Object Detection And Tracking Based On Fusion Of Radar And Camera On Highway Side, Zeng Yongqiang, Zhang Yonghua, Zhao Hui, Liu Xin, Xu Mingsheng, Shen Jianwei, Hu Zhiwei, Chen Zhenquan

Journal of China & Foreign Highway

Camera is the most widely used sensor in intelligent transportation systems (ITS),but the decline of detection and positioning accuracy caused by target occlusion and external environment interference has always been an important factor restricting the development of ITS.In order to solve this problem,a multi-mode fusion target detection and tracking method based on millimeter-wave radar (MWR ) and camera on highway side was designed.Compared with cameras,high-resolution MWR had better measurement accuracy and weather robustness,serving as a better complement to camera perception.The proposed method used the center point-based radar and camera fusion algorithm for target detection and adopted the greedy algorithm for …

Synthesis, Characterization, Antioxidant Content And Antibacterial Study Of New Ligand And Its Complexes From Sulfonic Acid And 2-Phthalaldehyde, Mawlood Khalid Mawlood, Wurood Ali Jaafar

Baghdad Science Journal

The research includes preparation of a new Schiff base from the condensation of sulfonic acid with 2-phthalaldehyde by dissolving (0.2 g, 0.346 mmole) of the ligand (L) in (10 ml) of absolute ethanol, then 0.06 g of potassium hydroxide (KOH) dissolved in 10 ml of distilled water added to it and reacting the product with some binary metal salts (Mn, Co, Ni, Cu, Cd, Zn, Pt, Hg). The biological study was conducted against two types of gram-positive and gram-negative bacteria, Staphylococcus. aureus and Escherichia coli, and the fungus Candida albicans was also used. All the prepared complexes showed …

Mobile Markets And Farmers’ Markets: Evaluating Food Accessibility For Underserved Communities In The Bay Area, Rajeshwari Rajesh

Master's Theses

Studies indicate including farmers’ markets, mobile markets, and other local food systems improve fresh food access for low-income communities, especially when paired with food assistance programs that offer financial incentives. This study aims to evaluate mobile markets and farmers’ markets in the Bay Area using the five dimensions of food access: accessibility, availability, acceptability, affordability, and accommodation. The study is based on primary data collected from 173 in-person surveys at six mobile and eight farmers’ markets in the Santa Clara and Contra Costa counties. Key survey participants were market shoppers participating in food assistance programs. A mixed research methodology included …

Green Ai-Enhanced Deep Learning Model For Breast Cancer Detection And Classification In Mammography Images: Bc-Net-512, Nesma Abd El-Mawla, Mohamed A. Berbar, Nawal A. El-Fishawy, Mohamed A. El-Rashidy

Mansoura Engineering Journal

This study champions a sustainable approach for developing a Deep Learning (DL) model for medical image analysis, specifically focusing on breast cancer (BC) detection in mammograms. By prioritizing low-computing algorithms to achieve high diagnostic accuracy while minimizing the model's environmental footprint, that aligns with the principles of Green AI. In this paper, an innovative architecture called BC-Net-512 was constructed for the classification of BC mammography. It is composed of lightweight Convolutional Neural Network (CNN) blocks for texture, density, and structure feature extraction and detection, a thin, fully connected layer for learning complex patterns and correlations in the extracted features, and …

Extensive Superficial Dermatomycosis Caused By Cladophialophora Sp., A Deep Mycosis Pathogen: A Case Report, Nikko Vanda Limantara, Agnes Sri Siswati, Flandiana Yogianti

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Superficial dermatomycosis, predominantly caused by dermatophytes, affects approximately 20–25% of the global population. However, non-dermatophytic fungi, such as Cladophialophora species (sp.), can also cause similar cutaneous infections. Although less common, these organisms are particularly concerning in immunocompromised individuals.

Case Illustration: A 66-year-old immunocompromised male presented with widespread pruritic and erythematous patches, initially misdiagnosed as tinea corporis. Despite receiving standard antifungal therapy, his condition persisted. Further investigation through fungal culture identified Cladophialophora sp., which was resistant to common antifungal agents such as fluconazole, itraconazole, and ketoconazole. However, the fungus was sensitive to terbinafine, which has …

Successful Management Of Generalized Pustular Psoriasis With Cyclosporine In Hiv-Infected Patient, Rasinta Ayudya Deltania, Anggun Putri Yuniaswan

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Generalized pustular psoriasis (GPP) can be associated with human immunodeficiency virus (HIV) infection, making its management more challenging and complex. This case report aims to evaluate the effectiveness and safety of cyclosporine in HIV-associated GPP.

Case illustration: A 31-year-old male with a six-year history of HIV on antiretroviral therapy presented with rapidly spreading erythematous plaques with scaling and patches, along with “lakes of pus”, involving 50% of the body surface area (BSA). He reported oral burning, dysgeusia, and odynophagia; tongue Gram stain showed budding yeast and pseudohyphae. The patient was diagnosed with GPP and oral candidiasis in the setting …

Laser And Light-Based Therapy For Hair Growth And Hair Removal, Michelle Wiryadana, Nelva Karmila Jusuf

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Recent advances in laser and light-based technologies have introduced new options for both the stimulation of hair growth for alopecia and the reduction of unwanted hair growth. However, the clinical evidence remains varied, and treatment outcomes are influenced by factors such as device type, wavelength, and individual response. Ongoing evaluation of safety, efficacy, and standardization of treatment parameters is therefore essential.

Discussion: This review provides an in-depth discussion of the principles, mechanisms, safety, and efficacy of lasers in promoting hair growth, as well as on lasers and light-based therapies used for hair removal. The mechanisms of laser-induced hair growth …

Variety Of Study Methods In Ophthalmology Residency, Muhammad Rizqy Abdullah, Evelyn Komaratih

Folia Medica Indonesiana

Effective study methods are critical in ophthalmology residency, which must balance cognitive learning with surgical skill development. This systematic review examined non-surgical cognitive strategies and surgical training techniques to inform curriculum design and enhance resident performance. A structured literature search was conducted in PubMed and Scopus (2016–2025) using keywords (“study method” OR “effective study” OR “learning strategy” OR “educational intervention” OR “training approach”) AND (“ophthalmology residency” OR “resident education”). After screening and applying eligibility criteria, 17 studies were included. Methods were categorized as non-surgical (n = 5) and surgical learning (n = 12). This review revealed that non-surgical strategies, including …

Dampit Robusta Coffee Effect On The Creatinine Kinase Levels And Muscle Pain Scales Among Sport Enthusiast, M. Fath Alhaqqi Sanis Salamy, Mohammad Fathul Qorib, Lilik Herawati, Rizky Darmawan, M. Izzul Mujahiddin, Salamun Salamun, Ahmed Zaiyan Nahel Salamy, Achmad Yarziq Mubarak Salis Salamy, Moh Nahar Azmi Mohamed, Ain Darojah Siddiq Ramadhan Ramadhan

Folia Medica Indonesiana

Excessive eccentric exercise often results in muscle injury, reflected by elevated serum creatine kinase (CK) levels and delayed onset muscle soreness (DOMS). In Indonesia, coffee consumption after exercise has increased, with Dampit Robusta Coffee (DRC)—a local variety rich in caffeine and antioxidants considered a potential aid for recovery. This study evaluated the effect of DRC consumption on biomarkers of muscle damage and perceived soreness. A single-blind randomized controlled trial was conducted on 20 healthy untrained men aged 20–25 years, allocated into treatment (n = 10) and control (n = 10) groups. The treatment group consumed brewed DRC (≈200 mg caffeine/day) …

Pathological And Molecular Parameters Show No Significant Association With Residual Cancer Burden In Breast Carcinoma, Fishella Aprista Rahmanti, Willy Sandhika, Lusiani Tjandra

Folia Medica Indonesiana

Residual Cancer Burden (RCB) is a validated scoring system that quantifies the amount of tumour remaining after neoadjuvant chemotherapy (NAC) for breast cancer, providing prognostic information beyond binary outcomes, such as pathologic complete response (pCR). pCR represents a binary endpoint within various NAC response-grading systems, including RCB, rather than a separate reporting system. This study aimed to assess clinicopathological and molecular predictors of RCB class, including histological grade, histopathological type, molecular subtype, and Ki-67 index. A retrospective study was conducted on 68 patients diagnosed with breast carcinoma who underwent NAC. Descriptive statistics and Pearson, Spearman, and chi-square tests were used …

How Narrative Storytelling On Social Media Develops Relationships Between Authors And Readers, Madelyn Woodson

Theses - ALL

With the rise of social media being used to sell products and connect communities, it is important to understand how creators are developing relationships with viewers. A specific community where this is evident is BookTok, where readers and authors can connect over shared interests. Understanding how, in this case, relationships are built between readers and authors can be broken down by looking at elements of trust, satisfaction, and commitment which stem from the Organization Public Relationship (OPR) theory developed by Hon and Grunig (1999). Research has shown that personalization and storytelling when creating content and communicating with publics develops a …

Dysconscious Ableism In The Public Library Advancing Disabled Patron And Staff Experiences Toward More Inclusive Programs And Services, William N. Myhill

Dissertations - ALL

This dissertation investigates the operation of dysconscious ableism in public librarianship and its impact on disabled patrons and staff. Drawing on critical disability studies, critical theory, and ethnographic methods, the study explores how public library policies, practices, and professional beliefs perpetuate ableist norms and marginalize disabled individuals. The research is grounded in three central questions: (1) How does dysconscious ableism operate in public librarianship? (2) What are the lived experiences of disabled patrons and staff in public library spaces? (3) What strategies can disrupt dysconscious ableism and promote a more inclusive, anti-ableist praxis? Data were collected through interviews with librarians …