Concordance Of Fluorescence In Situ Hybridization, Whole-Exome Sequencing, And Chromosomal Microarray For Evaluating High-Risk Molecular Features In Meningiomas, Brenndan Crumley, Emilie Russler-Germain, Sonika Dahiya

2020-Current year OA Pubs

BACKGROUND: Meningiomas are the most common primary intracranial tumors, classified into three WHO grades based on histologic and/or molecular criteria. cIMPACT-NOW Update 8 underscores the increasing importance of molecular testing in grading and risk stratification, noting that morphologically WHO grade 1 tumors with concurrent 1p and 22q losses demonstrate clinical behavior comparable to WHO grade 2 meningiomas. This study aimed to assess the concordance of fluorescence in situ hybridization (FISH), chromosomal microarray analysis (CMA), and whole-exome sequencing (WES) in defining the molecular risk profile of meningiomas.

METHODS: A total of 113 meningiomas were analyzed by WHO grade to assess the …

Immortalization And Characterization Of Schwann Cell Lines Derived From Nf1-Associated Cutaneous Neurofibromas, Hua Li, Angela Hirbe, Et Al.

2020-Current year OA Pubs

Neurofibromatosis type 1 (NF1) is an autosomal dominant condition in which patients are heterozygous for a disruptive pathogenic variant in the NF1 gene. The most characteristic feature of the condition NF1 is the neurofibroma, a benign, multi-cellular tumor which initiates when a cell of the Schwann cell lineage gains a somatic pathogenic variant of the other NF1 allele. Neurofibromas developing at nerve termini in the skin are termed "cutaneous" neurofibromas (cNFs), while those developing within larger nerves are termed "plexiform." Most patients develop cNFs beginning in late childhood or early adulthood, continuing throughout life at variable rates. Some patients may …

Spatial Variation In Socio-Economic Vulnerability To Influenza-Like Infection For The Us Population, Shrabani S. Tripathy, Joseph V. Puthussery, Taveen S Kapoor, John R. Cirrito, Rajan K. Chakrabarty

2020-Current year OA Pubs

This study aims to quantify environmental health impacts and assess risk by understanding the disproportionate burden of infectious diseases, specifically Influenza-like Illness (ILI), across regions with varying socio-economic characteristics. We introduce a novel vulnerability-based approach to better understand the complex relationship between socio-economic factors and ILI burden. We develop a machine-learning-driven framework to assess and map state-level socio-economic vulnerability to ILI in the United States. A vulnerability index was created by integrating 39 diverse socio-economic and health indicators from the latest CENSUS. A Random Forest Regression model then weighed these indicators to quantify each state's vulnerability for the ILI values …

Characterization Of The Spatiotemporal Representations Of Visual, Semantic, And Memorability Features In The Human Brain, Yue Wang, Peter Brunner, Jon T. Willie, Runnan Cao, Shuo Wang

2020-Current year OA Pubs

Object recognition requires integrated processing that extends beyond the visual cortex, incorporating semantic and memory-related processes. However, it remains unclear how different attributes, such as visual, semantic, and memorability features, are encoded and interact during perception. Here, we recorded intracranial electroencephalography from 5,143 channels while participants viewed natural object images. We systematically characterized the spatiotemporal patterns of neural encoding for visual, semantic, and memorability attributes and showed that memorability was encoded in a distributed manner, which can be dissociated from visual and semantic coding. While the ventral temporal cortex (VTC) was engaged in encoding all three attributes, the representations were …

Capacity And Site Readiness For Hypertension Control Program Implementation In Nigeria: A Nationwide Cross-Sectional Study, Innocent Ijezie Chukwuonye, Mark D. Huffman, Et Al.

2020-Current year OA Pubs

BACKGROUND: The aim of this study is to determine the capacity and readiness of Nigerian primary healthcare facilities to adopt a multi-level approach for the diagnosis, treatment, and control of hypertension.

METHODS: Using a multi-stage sampling technique, 5 states were selected for the nationwide study, and 10 Primary Healthcare Centres (PHCs) were selected from each of the participating states. The 50 PHCs were evaluated using the World Health Organization-modified Service Availability and Readiness Assessment, focusing on the diagnosis and treatment of hypertension in Nigeria. The indicator scores for general and cardiovascular service preparedness were computed using the proportion of PHCs …

An Emerging Timer-2c Framework For Addressing Barriers To Research Culture And Productivity Among Local Healthcare Providers In The Middle East And Sub-Saharan Africa: A Qualitative Study And Modified Delphi Approach, Beryne Odeny, Dorothy Mangale, Dhananjaya Sharma, Mariam Balogun, Elizabeth Bukusi, Fatima Suleman, Miliard Derbew, Juliet Iwelunmor, Ermyas Birru, Isaac Che Ngang, Akila Anandarajah, Vaishnavi Mamillapalle, Wael Almahmeed

2020-Current year OA Pubs

Contributions from healthcare professionals in the Middle East and North Africa (MENA) and sub-Saharan Africa (SSA) to global health research remain disproportionately low. We conceptualized the TIMER-2C framework to capture the multi-level barriers and facilitators shaping research productivity among local healthcare professionals in MENA and SSA. We conducted qualitative interviews using a modified Delphi approach comprising two rounds to: 1) identify barriers and facilitators, and 2) establish consensus on the most prominent factors influencing research productivity. We purposively sampled 17 participants from Jordan, Qatar, Egypt, Lebanon, North Sudan, South Sudan, Nigeria, Ghana, Kenya, Uganda, Ethiopia, South Africa and India. Interview …

Implementing The Lung Donor (Lundon) Acceptability Score In U.S. Donor Management And Transplant Decision-Making: A Multi-Aim, Mixed-Methods Protocol, Nikki E. Rossetti, Su-Hsin Chang, Yan Yan, Graham Jaensch-Frie, Charles R. Liu, Nahom Y. Seyoum, Meghna Katta, Arvind Kumar, Zhizhou Yang, Christian Oncken, Christy Hamilton, Kyle Stumbaugh, Brendan Heiden, Sarah Peskoe, Varun Puri, Et Al.

2020-Current year OA Pubs

BACKGROUND: Despite advances in transplantation science, a persistent shortage of donor lungs continues to limit access to life-saving lung transplants. The Lung Donor (LUNDON) Acceptability Score is a validated tool that predicts donor lung utilization and post-transplant recipient outcomes, but integration into practice remains limited. This study will evaluate determinants of LUNDON score adoption, its impact on clinical decision-making, and develop tools to support its implementation.

METHODS: This is a multi-aim mixed-methods pre-implementation study that will be conducted across U.S. Organ Procurement Organizations (OPOs) and lung transplant centers. Aim 1 will identify barriers and facilitators of LUNDON score adoption through …

Chronic Oral Cannabidiol Delays Seizure Onset And Reduces Seizure Burden In A Mouse Model Of Cln2 Disease, Joshua T. Dearborn, Keigo Takahashi, Nicholas R. Rensing, Michael Wong, Jonathan D. Cooper, Mark S. Sands

2020-Current year OA Pubs

A growing body of literature describes the anti-inflammatory, neuroprotective, and anti-epileptic properties of the cannabis sativa constituent cannabidiol, suggesting that it might play a useful role in the treatment of neurodegenerative diseases. Late infantile neuronal ceroid lipofuscinosis (CLN2 disease) is a rare pediatric neurodegenerative disorder resulting from an inherited dysfunction of the lysosome. CLN2 disease, and its representative animal models, display neuroimmune response, neuroinflammation, neurodegeneration, and epileptic seizures, and these symptoms are all touted as potential targets of cannabidiol therapeutic benefit. Here, we treated a valid model of CLN2 disease with long-term daily cannabidiol (300 mg/kg) from 1 month of …

The Operation And Control Strategy Of Microgrids: A Brief Review, Mohammad Alam, Salsabila Zaman

Electrical Engineering Student Publications

A microgrid is an effective approach for integrating various distributed energy resources to meet local energy demand. It possesses the capability to operate independently or in conjunction with the main utility grid. Typically, a microgrid is a small-scale power system (usually several megawatts or less) comprising three primary components: the ability to function in both grid-connected and islanded modes, distributed power generation sources, and autonomous control centers. Microgrids enhance system resilience by ensuring uninterrupted operation during grid disturbances. Additionally, they are environmentally sustainable and contribute to improved power quality. As a crucial element of modern power systems, microgrids can effectively …

Perceptions Of Georgia Elementary School Administrators Toward Elementary Agricultural Education, Addie Tucker

Murray State Theses and Dissertations

Elementary agricultural education (EAE) is a growing component of K-12 agricultural education, yet limited research exists on how school leaders perceive its value. The purpose of this study was to explore the perceptions of Georgia elementary school administrators regarding the implementation and value of EAE programs. Specifically, this study examined elementary principals’ and district superintendents’ views on the benefits, effectiveness, and value of EAE. A descriptive research design was used. Georgia elementary principals and district superintendents with active EAE programs during the 2025-2026 academic year were surveyed in the fall of 2025. The sample consisted of 18 principals and 18 …

Identifying The Knowledge And Skills That Students Enrolled In Agricultural Systems Technology Degree Programs Need: Perspectives From University Faculty, Jerry Blake Kennedy

Murray State Theses and Dissertations

National trends have highlighted the need for a knowledgeable, skilled workforce in advanced agricultural systems. University-level Agricultural Systems Technology (AST) undergraduate degree programs and closely-related degree programs are vital to equipping the agricultural workforce with the knowledge and skills needed to support the industry. Ensuring that AST curricula are relevant and appropriate is vital to equipping undergraduate students in such programs with the knowledge and skills they need to succeed in the modern agricultural workforce. This study sought to identify the essential knowledge and skills needed by undergraduate AST degree program students from the perspectives of university-level faculty across the …

Speaking For The Families: Organizational Socialization Of Military Spouses In Volunteer Leader Positions, Virginia Klaus

Murray State Theses and Dissertations

Military spouses holding volunteer leadership positions in military unit family readiness groups, provide a link between commanders and families of service members. They act within military organizations as the only official voice of spouses, a stakeholder group recognized as influential in retention rates and force readiness. Despite their importance, military spouses are often portrayed in research as passive members, taking on roles to meet the expectations of their peers and military organizations. That contradicts historical evidence of military spouses as active organizational members who have socialized other spouses, and as family advocates who have challenged military organizational practices and policies. …

Personality Assessment Inventory Profiles In Adults Seeking Autism Spectrum Disorder Assessment, Emily Kinsey

Murray State Theses and Dissertations

The current study aimed to examine differences in interpersonal functioning and response validity among adults presenting for autism spectrum disorder (ASD) assessment compared to those seeking services for other clinical concerns. The study used archival data from 238 client files collected in an outpatient clinical setting. Interpersonal functioning was assessed using the Dominance (DOM), Warmth (WRM), and Nonsupport (NON) subscales of the Personality Assessment Inventory (PAI; Morey, 1991). Response validity was evaluated using the Negative Impression Management (NIM) and Positive Impression Management (PIM) scales. A multivariate analysis of variance (MANOVA) showed no significant group differences across DOM, WRM, and NON …

Wired For Inclusion: Leveraging Strengths Of Neurodivergent Special Educators, Brok Hess, Teresa Clark Ed.D.

Murray State Theses and Dissertations

Special education teachers face unique challenges, and neurodivergent special educators possess distinctive strengths that can allow them to excel in the classroom. However, barriers, stigma, and ableism persist that have prevented neurodivergent individuals from accessing this career, receiving support, and thriving as special educators. Self-efficacy and executive functioning both correlate to success and retention within education. This research analyzed the relationship between special education teachers’ self-efficacy and executive functioning, specifically among neurodivergent special educators. Results concluded that a significant positive correlation exists between neurodivergent special education teachers’ executive functioning and self-efficacy. Attention to these results will highlight the importance of …

Don’T Give The Fae Your Name: Focus Of Attention And Victim Blaming, Entropy Cramer

Murray State Theses and Dissertations

Victim-blaming is thought to be a result of the fundamental attributional error, where people over-emphasize internal attributions about the victim. Despite this, there is little literature on manipulating the focus of attention and the result for victim-blaming. People who are high in rape myth acceptance tend to visually focus on the victims longer (Süssenbach et al., 2015). Rempala and Bernieri (2005) found that adding irrelevant information, such as height and weight, to the trial about the victim increased victim-blaming compared to when it was absent. The current study investigated if relevant information about the victim and perpetrator changed the amount …

Out In The Arena: Examining The Lgbtq+ Experience In Ihsa, Katharine C. Didier

Murray State Theses and Dissertations

This study investigated factors influencing Intercollegiate Horse Show Association (IHSA) LGBTQ+ riders’ perceptions of inclusion, safety, and belonging, with the hypothesis that teams with diversity and inclusion policies would be perceived as more accepting. An online survey was developed to gather information from self-identified LGBTQ+ IHSA students. Questions covered demographics, team environment, and perceived inclusivity within their equestrian programs. Question types included multiple choice, Likert-type, short answer, and open-ended. IHSA coaches were asked to share the survey link with team members. Students were able to respond anonymously. The survey was open for 8 weeks. Reminders were sent out at 3 …

Attention Or Affect? Evaluating The Discriminant Validity Of Cpt-3 Performance, Gavin F. Price

Murray State Theses and Dissertations

The Conner Continuous Performance Test Third Edition (CPT-3) is a behavior-based measure of attention-related problems commonly used to assess Attention-Deficit/Hyperactivity Disorder (ADHD). Research into the discriminant validity of the CPT-3 remains limited, particularly regarding the influence of internalizing symptoms such as anxiety and depression on performance. The current study examined whether CPT-3 performance was more strongly associated with cognitive indicators of inattention or internalizing symptoms, such as depressive or anxious symptoms. Archival data from 105 adult clients at Murray State University Psychological Center was analyzed. Cognitive inattention was measured using Verbal Comprehension Index (VCI) – Working Memory Index (WMI) discrepancy …

Comprehensive Postsecondary Transition Planning For Students With Intellectual Disability In Florida, Sonia Y. Clark-Rosier

Murray State Theses and Dissertations

The purpose of this qualitative study was to explore the impact of early transition planning on parents’ postsecondary expectations for their child with an intellectual disability and to examine the benefits of planning, particularly when considering higher education opportunities. This study also probed the factors that contribute to the development of self-efficacy in special education teachers facilitating comprehensive transition planning. Schlossberg’s transition theory, with its four S’s—situation, support, self, and strategies—served as the theoretical framework. The data collection methods were document analysis, focus groups with special education teachers, high school teachers, and parents, and researcher observations. Seven themes emerged to …

The Economic Impact Of The Georgia Young Farmers Association On Georgia's Economy, Robert E. Bodiford Iii

Murray State Theses and Dissertations

Agriculture is Georgia’s largest economy, generating billions of dollars annually. Sustaining this sector requires ongoing investment in human capital through education, training, and leadership development. While research has extensively examined youth agricultural education, limited attention has been given to the economic contributions of adult agricultural education programs. The Georgia Young Farmers Association serves as a primary provider of structured adult agricultural education in the state, offering continuing education through meetings, farm tours, workshops, and leadership development activities. The purpose of this study was to estimate the economic impact of the Georgia Young Farmers Association on Georgia’s economy[BL1] . The …

Academic Growth From Preact To Act: The Influence Of Socioeconomic Status And Attendance In A Rural Alabama High School, Stacy L. Tinch

Murray State Theses and Dissertations

The purpose of this quantitative correlational study was to examine academic growth from the PreACT to the ACT among students attending a rural public high school in Alabama and to investigate whether socioeconomic status (SES) and attendance were associated with differences in that growth. Guided by Opportunity-to-Learn Theory, the study explored whether students demonstrated academic growth during high school and whether SES, attendance, or the interaction between these variables influenced growth outcomes. Archival student-level data were collected from four graduating cohorts. The final sample consisted of 384 students with complete records for PreACT scores, ACT scores, attendance, and socioeconomic status. …

An Analysis Of Systemic And Contact Herbicide Usage Trends In Illinois Corn Production Systems, Paige E. Mckittrick

Murray State Theses and Dissertations

Herbicide use is central to weed management in Illinois corn production; however, long-term changes in the balance between systemic and contact herbicides have not been well quantified at the statewide scale. This study analyzes herbicide trends in Illinois corn from 1982 to 2016 using secondary data from the USDA Agricultural Chemical Use Survey, paired with climate, regulatory, and herbicide resistance information. Herbicide active ingredients were classified into systemic and contact functional categories and grouped according to Weed Science Society of America (WSSA) mode-of-action (MOA) codes. For each survey year, total herbicide load (lb a.i./acre), functional proportions, MOA-specific contributions, and a …

Parent And Family Engagement In Middle Schools: A Qualitative Exploration Of Parent Perspectives And Student Success In West Tennessee, Angela Y. Searcy

Murray State Theses and Dissertations

Abstract

Parent and family engagement in middle school has been demonstrated to increase students' academic achievement; however, barriers often prevent parental participation. This study focused on parents' and teachers' perceptions of the parents' role in the educational process and sought to answer research questions about parents' perceptions, parents as equal partners in the educational process, and barriers to parental participation. A qualitative research design was used for the study. Teachers and parents from a middle school in West Tennessee participated in interviews to generate data used in this study. Teachers and parents identified common themes affecting the parent-school partnership, including …

Barriers To Mental Healthcare Among Men, Adrienne White

Murray State Theses and Dissertations

Men are consistently less likely than women to seek professional mental health services despite experiencing significant rates of depression and psychological distress. Traditional masculine norms and depression-related stigma have been proposed as major contributors to this disparity. The present study examined the relationships among depression stigma, conformity to masculine norms, depression severity, perceived barriers to care, and attitudes toward seeking professional mental health treatment among adult men with current or past depression. Seventy participants completed measures of depression severity (PHQ-9), conformity to masculine norms (CMNI-30), depression stigma (DSS), attitudes toward help seeking (MHSAS), and perceived barriers to care (BMHS). Contrary …

Career And Technical Education Readiness Trends Across Kentucky High Schools And Workforce Regions: A Longitudinal Analysis, Brittany Forgey

Murray State Theses and Dissertations

Career and Technical Education (CTE) has become an increasingly important component of Kentucky’s educational accountability system and workforce development initiatives. Despite expanded emphasis on career readiness and technical skill attainment, limited research has examined long-term trends in CTE readiness across Kentucky public high schools. The purpose of this quantitative, non-experimental, longitudinal study was to examine trends in CTE readiness indicators from 2011 through 2025. Human Capital Theory and Social Capital Theory provided the conceptual framework. Publicly available data from the Kentucky Department of Education School Report Card, KYStats, Supplemental Career and Technical Education reports, and other Kentucky Department of Education …

The Weight Of Stigma, Rebekah A. King, Michael S. Sinha

All Faculty Scholarship

Many health care providers, both implicitly and explicitly, perpetuate stigma in their treatment of patients classified as obese. While medical professionals understand that a one-size-fits-all approach to treatment is ineffective, patients classified as obese are frequently offered limited treatment options that fail to account for their unique needs. Access to a range of effective treatment options has historically been limited, but new GLP-1 receptor agonist medicines like Wegovy (semaglutide) and Zepbound (tirzepatide), have shown incredible promise in addressing the obesity crisis. Unfortunately, these transformative drugs are costly, in high demand, and not widely covered by insurance, rendering them inaccessible for …

Integrating Human Rights Into State And Federal Court Litigation, Lauren E. Bartlett

All Faculty Scholarship

Human rights have never been more important in the United States as they are today. After more than 10 years of dormancy, the seminal work that guides public interest attorneys in incorporating human rights work has been finally updated. The Human Rights in the U.S. Handbook for Public Interest Attorneys is a handbook that provides practical direction to public interest attorneys, including clinical law teachers, legal aid attorneys, public defenders, and others, on how to use human rights in their everyday work. The Handbook invaluably advises attorneys on best practices for using human rights arguments before U.S. state and federal …

The Asexual Assumption, Faith K. Whatley-Blaine, Michael S. Sinha

All Faculty Scholarship

Inclusion-focused dating shows such as ‘Love on the Spectrum’ feature individuals with developmental or neurological disabilities on a quest for love. Despite the focus on disability representation, these shows perpetuate stigma against the disabled community by fostering an infantilizing portrayal of individuals with disabilities. This portrayal undermines the premise of encouraging meaningful romantic relationships and reinforces the stigmatizing association of asexuality with disability. This framing aligns with the broader societal narrative that individuals with disabilities are incapable of or lack interest in participating in romantic relationships or physical intimacy.

The stigma that associates asexuality with disability extends beyond mere entertainment, …

Library Support For Massive Open Online Courses (Moocs) In The Philippines: The Case Of American Corners, Princess Grace Wooden, Darin Jan Tindowen

Library Philosophy and Practice (e-journal)

This study examined the role of libraries in supporting Massive Open Online Courses (MOOCs) in the Philippines, with particular focus on American Corners as library-based learning spaces. Grounded in the increasing demand for flexible and accessible education, the study aimed to assess the readiness of American Corner libraries and determine the extent of MOOC implementation, as well as examine the relationship between these variables. A quantitative descriptive-correlational research design was employed, involving 28 American Corner staff composed of directors and librarians from 14 participating institutions. Data were collected using a validated survey questionnaire and analyzed through frequency, percentage, weighted mean, …

Uncovering The Disciplinary Pulse Of Library And Information Science Through Large-Scale Topic Modelling Of Openalex Scholarly Literature, Sailendra Malik, Sukumar Mandal

Library Philosophy and Practice (e-journal)

Library and Information Science is among the oldest and intellectually pluralistic scholarly disciplines but the inner thematic structure has not been established. The article develops a systematic and data intensive mapping of the field by the Latent Dirichlet Allocation topic modelling to 7,824 articles in the English language indexed in OpenAlex in the year 2000 to 2025. A ten topic solution is an optimised solution that identifies a group of readable and sensible thematic domains including information literacy digital libraries scientometrics archives and scholarly communication. The analysis of temporal trajectory reveals that there have been consistent expansion at the emergent …

Rethinking Library Opac: From Siloed Retrieval To Ai And Ml-Driven Discovery Using Fastapi And Mysql, Sukumar Mandal

Library Philosophy and Practice (e-journal)

The paper explores integration methods between MySQL and FastAPI to develop dynamic Online Public Access Catalog services including functionalities for modern libraries and information centers. It addresses evolving user expectations by replacing rigid keyword-based search models with adaptive, intelligent discovery experiences that prioritize search relevance. The goal involves transforming traditional library retrieval tools into contextual discovery platforms that effectively understand specific user intent and complex needs. The prototype was created on Ubuntu in a customized Python environment. It uses FastAPI to manage asynchronous API calls and MySQL to store bibliographic data. SQLAlchemy abstracts the database layer, and Pydantic validates data. …