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Articles 57871 - 57900 of 2917266
Full-Text Articles in Entire DC Network
Modeling Of Laser-Produced Plasma Plumes: Expansion, Chemistry, And Thin-Film Deposition, Edmund Tsiri Semaha, Edmund Tsiri Semaha
Modeling Of Laser-Produced Plasma Plumes: Expansion, Chemistry, And Thin-Film Deposition, Edmund Tsiri Semaha, Edmund Tsiri Semaha
Theses and Dissertations
Abstract
Laser-assisted material processing involves coupled plasma expansion, chemical reactions, and particle transport that govern the quality of thin-film deposition. This dissertation presents a comprehensive computational investigation of these processes using the OpenFOAM framework. First, the performance of the twoPhaseEulerFoam (tPEF), rhoCentralFoam (rCF), and sonicFoam (sF) solvers is evaluated for modeling laser-produced plasma plume expansion under atmospheric conditions, demonstrating that tPEF accurately captures shock-wave propagation, hydrodynamic behavior, and multispecies interactions. Building on this validation, the reactingFoam (rF) solver is employed to investigate the chemistry of aluminum plasma expanding into an air environment (Al–N₂–O₂). The model incorporates appropriate thermodynamic, transport, and …
Positive Body Image In Postpartum Women: A Psychometric Evaluation Of The Body Appreciation Scale-2 And A Phenomenological Exploration, Taylor Vashro
Positive Body Image In Postpartum Women: A Psychometric Evaluation Of The Body Appreciation Scale-2 And A Phenomenological Exploration, Taylor Vashro
Theses and Dissertations
Postpartum women appear particularly vulnerable to body dissatisfaction due to the rapid physiological, emotional, and environmental changes that occur across the perinatal experience (Baskin et al., 2021; Nippert et al., 2021). Recent studies have demonstrated the experience of both negative and positive body image during postpartum (Rodgers et al., 2024; Watson et al., 2016). However, there is limited research regarding the measurement and exploration of positive body image in postpartum women. The current study aimed to: 1) evaluate the factor structure and psychometric properties of the Body Appreciation Scale-2 (BAS-2), a widely used measure of positive body image in postpartum …
Introducing Consensus Library, Joanne Romano
Introducing Consensus Library, Joanne Romano
TMC Library Newsletter (2015-)
No abstract provided.
Assessment Of Major Adverse Cardiovascular Event Across Diverse Racial Groups Of Psoriasis Patients On Biologic Therapy: A Retrospective Cohort Study, Chunghwan Ro, Ana Ormaza Vera, Waleed Adawi, Clinton W. Enos
Assessment Of Major Adverse Cardiovascular Event Across Diverse Racial Groups Of Psoriasis Patients On Biologic Therapy: A Retrospective Cohort Study, Chunghwan Ro, Ana Ormaza Vera, Waleed Adawi, Clinton W. Enos
Department Dermatology Faculty Publications
Psoriasis is associated with an increased risk of major adverse cardiovascular events (MACE), and biologic therapy may reduce this risk by targeting systemic inflammation. However, limited data exist on whether long term MACE risk differs by biologic class or across racial groups. We conducted a retrospective cohort study to assess the risk of primary MACE in psoriasis patients receiving biological therapies, stratified by biological class, compared with biologic-naïve psoriasis patients. Whether MACE risk among biologic-treated patients varied by race was further examined. After 1:1 propensity score matching, 36 330 biologic-treated patients were compared with 36 330 non-biologic-treated patients. Incident MACE …
The Development And Initial Validation Of A Measure Of Professional Mentoring Engagement Among School Counselors, Emily Kitching
The Development And Initial Validation Of A Measure Of Professional Mentoring Engagement Among School Counselors, Emily Kitching
Theses and Dissertations
This study describes the development and initial validation of the Mentoring Engagement Scale (MES), a self-report instrument designed to measure a person’s level of engagement in professional mentoring. Despite emerging evidence that professional mentoring may serve as a protective factor against the burnout and stress associated with school counselors’ roles and responsibilities, existing measures of mentoring are limited by weak documentation of development procedures, mixed psychometric support, and limited practical applicability. In two phases, the present study aimed to (1) evaluate content validity and systematically refine items grounded in Kahn’s (1990) theory of engagement and (2) investigate the preliminary psychometric …
Dodgeballs And Dragons: Gamified Live Theatre In The Service Of Community Betterment, Teddy Mcpherson
Dodgeballs And Dragons: Gamified Live Theatre In The Service Of Community Betterment, Teddy Mcpherson
Theses and Dissertations
This thesis qualifies and documents a new genre of interdisciplinary, interactive theatre called Dodgeballs and Dragons. It covers a brief history of Dungeons and Dragons and Theatre of the Oppressed (the two foundational works for the new genre) as well as previous uses of D&D as a form of theatrical entertainment. After establishing the precedence used to create this product, the rest of the thesis breaks down how to write, lead, and play these shows on a regular basis. The document culminates in collected data providing concrete evidence for the future of the form and its many applications.
Conceptual Concerns Regarding The Content Validity Of The Construct Of Gender Dysphoria In The Diagnostic And Statistical Manual Of Mental Disorders, Fifth Edition, Text Revision, Waverley Vesely
Theses and Dissertations
The diagnostic classification of gender dysphoria in the DSM-5-TR elicits a number of clinical, political, and philosophical concerns, ranging from those that are diagnostic and taxonomical in nature to those that fall within the domains of ontology, phenomenology, and hermeneutics. Part of the reason for the complexity of studying the diagnostic and nosological validity of gender dysphoria as an extant diagnostic classification is that, unlike many disorders, gender dysphoria is inextricably tethered to identity. While the recent change from gender identity disorder to gender dysphoria has nominally removed the status of disorder, in practice, both clinicians and the general population …
Optimizing Markov Chain Monte Carlo Algorithms For Fairness, Scalability, And Interpretability In Electoral Redistricting, Madhukara Kekulandara
Optimizing Markov Chain Monte Carlo Algorithms For Fairness, Scalability, And Interpretability In Electoral Redistricting, Madhukara Kekulandara
Open Access Dissertations
Gerrymandering undermines democratic representation by manipulating electoral district boundaries to dilute the political influence of targeted communities. While Markov Chain Monte Carlo (MCMC) based redistricting algorithms have become a standard computational tool for detecting partisan gerrymandering, their effectiveness in addressing racial gerrymandering and their scalability on modern computing systems remain limited. This dissertation advances the theory and practice of algorithmic redistricting by optimizing MCMC-based approaches across three dimensions: racial fairness, computational efficiency, and interpretability.
First, this work introduces the Partial Map MCMC algorithm, a novel redistricting method designed specifically to address racial gerrymandering under the legal framework of Section 2 …
Coached By A Custom Chatgpt And Ready For Trial, Staci J. Pratt
Coached By A Custom Chatgpt And Ready For Trial, Staci J. Pratt
Publications
No abstract provided.
Developer Perspectives On Licensing And Copyright Issues Arising From Generative Ai For Software Development, Trevor Stalnaker, Nathan Wintersgill, Oscar Chaparro, Laura A. Heymann, Massimiliano Di Penta, Daniel M. German, Denys Poshyvanyk
Developer Perspectives On Licensing And Copyright Issues Arising From Generative Ai For Software Development, Trevor Stalnaker, Nathan Wintersgill, Oscar Chaparro, Laura A. Heymann, Massimiliano Di Penta, Daniel M. German, Denys Poshyvanyk
Faculty Publications
Despite the utility that Generative AI (GenAI) tools provide for tasks such as writing code, the use of these tools raises important legal questions and potential risks, particularly those associated with copyright law. As lawmakers and regulators respond to these questions, the views of users can offer relevant perspectives. In this article, we provide: (1) a survey of 574 developers on the licensing and copyright aspects of GenAI for coding, as well as follow-up interviews; (2) a snapshot of developers’ views at a time when GenAI and perceptions of it were rapidly evolving; and (3) an analysis of developers’ perspectives, …
Spectrum Of Neurodevelopmental Disorders In Children Attending A Developmental Clinic In Dar Es Salaam, Tanzania, Aleya Zulfikar Remtulla, Sumayyah Nasiruddin Saudin, Orujul Hassan, Mariam Noorani
Spectrum Of Neurodevelopmental Disorders In Children Attending A Developmental Clinic In Dar Es Salaam, Tanzania, Aleya Zulfikar Remtulla, Sumayyah Nasiruddin Saudin, Orujul Hassan, Mariam Noorani
Paediatrics and Child Health, East Africa
Background: Neurodevelopmental disorders (NDDs) in children present significant challenges for healthcare systems globally. In Tanzania, children with NDDs and their families face significant challenges due to late diagnosis, lack of standardized screening tools, widespread stigma and cultural beliefs that deter health-seeking behaviours. Awareness about NDDs is low, and financial constraints further complicate access to necessary medical interventions. The country suffers from a severe shortage of specialized healthcare providers, and general healthcare providers often lack adequate training. Additionally, limited specialized facilities, high treatment costs and insufficient healthcare policies dedicated to NDDs make it difficult to manage these conditions effectively. Understanding the …
(Reverse) Piercing The Trust Veil, Eric Kades
(Reverse) Piercing The Trust Veil, Eric Kades
Faculty Publications
Emergent doctrine deems trusts legal entities distinct from their trustees and beneficiaries. Venerable doctrine empowers creditors to "pierce the veil" separating entities' and their owners' property to avoid inequitable treatment. This article weaves together the new and old to craft a legal roadmap for reversing the ongoing race to the bottom among the states authorizing indefensible self-settled asset protection trusts (SSAPTs) designed solely for the purpose of swindling creditors. As a matter of both policy and doctrine, piercing (more precisely, reverse piercing) an entity's veil is ideally suited to empower the creditor of a SSAPT beneficiary to get paid from …
Firearms And Fora: Constructing Public Carry Doctrine, Timothy Zick
Firearms And Fora: Constructing Public Carry Doctrine, Timothy Zick
Faculty Publications
Where can a person lawfully carry firearms in public? Under what conditions can they do so? Now that the Supreme Court has formally recognized a Second Amendment right to public carry, these are among the most important unresolved questions regarding the right to bear arms. The Second Amendment’s public carry doctrine is in its infancy. How the doctrine develops will have a profound impact on the exercise of Second Amendment rights in public places and on the public square. Integrating a new constitutional right into the public square is not a novel problem. After the Supreme Court recognized First Amendment …
The Library Of Congress At A Crossroads: Executive Overreach And The Future Of Public Knowledge, Leslie A. Street, Amanda M. Runyon
The Library Of Congress At A Crossroads: Executive Overreach And The Future Of Public Knowledge, Leslie A. Street, Amanda M. Runyon
Library Staff Publications
This Article argues that the removal of the Librarian of Congress and the Register of Copyrights exposed a dual vulnerability: a constitutional breach of the separation of powers and a cultural threat to the nation’s knowledge infrastructure. The Library’s structural ambiguity—its simultaneous identity as a legislative library, national library, and copyright agency—has left it vulnerable to executive overreach. By asserting control over an institution designed to serve Congress and safeguard America’s intellectual heritage, the President destabilized a statutory framework that has endured for over two centuries. To protect both constitutional integrity and the Library’s role as custodian of national memory, …
The Specter Of Jury Nullification, Anna Offit
The Specter Of Jury Nullification, Anna Offit
Faculty Publications
Attention to the trial of Luigi Mangione has renewed debate about nullification—the jury’s inviolate power to acquit a defendant contrary to the evidence presented. Jury nullification proponents hold that it is a mechanism of last resort for refusing to apply laws that conflict with the public conscience. Opponents, by contrast, argue that nullification undermines the law by diminishing its legitimacy. To prosecutors and defense attorneys, however, these arguments are immaterial: Jury nullification is part of the institutional landscape of the contemporary jury trial and thus must be treated as a potentiality—a feature of the agnostic, strategic, and ethical terrain of …
The Executive's Takeover Of Independent Agencies: How Institutional Design Gave Way To Political Will, Neal Devins
The Executive's Takeover Of Independent Agencies: How Institutional Design Gave Way To Political Will, Neal Devins
Faculty Publications
The anticipated demise of the independent agency is a saga that implicates Congress as much as it does the President or the Supreme Court. By capitulating to presidential initiatives and failing to defend their institutional prerogatives, Congress has facilitated presidential control of the administrative state. Indeed, irrespective of whether the Court formally repudiates Humphrey’s Executor, Congress has largely acquiesced to a regime whereby presidents essentially control independent agencies. By highlighting the competing incentives of Congress and the White House, this Essay explains the rise of presidential unilateralism vis-à-vis independent agencies. This Essay also casts light on a critically important but …
Mirabile Dictu: The Bryn Mawr College Library Newsletter 29 (2026), Bryn Mawr College Library
Mirabile Dictu: The Bryn Mawr College Library Newsletter 29 (2026), Bryn Mawr College Library
Mirabile Dictu: Newsletter of the Bryn Mawr College Libraries
No abstract provided.
The Police Archipelago: Decentralization, Police Violence, Over-Punishment, And Crime, José F. Girón
The Police Archipelago: Decentralization, Police Violence, Over-Punishment, And Crime, José F. Girón
Faculty Publications
A strong consensus has taken hold in the legal academy. Criminal Justice Localism, espoused by scholars of every stripe, promotes greater local control of every facet of the criminal justice system. But Criminal Justice Localism largely overlooks an institution that plays a critical role in the criminal justice system, and which has been the subject of intense public criticism: the police. That oversight is remarkable for two reasons. First, calls for increased local control of the police seem to ignore that America operates one of the most—if not the most—decentralized policing models in the world, with its thousands of local, …
Armstrong V. Elizabeth, Southern District Of New York
Armstrong V. Elizabeth, Southern District Of New York
Historical and Topical Legal Documents
No abstract provided.
Survivors Of Historical Intergenerational And Familial Trauma Scale For Black American Descendants Of Enslaved People: A Development And Initial Validation Study, Loryn Chás Kimbrough
Survivors Of Historical Intergenerational And Familial Trauma Scale For Black American Descendants Of Enslaved People: A Development And Initial Validation Study, Loryn Chás Kimbrough
Graduate Research Theses & Dissertations
Despite extensive research documenting cultural and racialized trauma, no validated assessment tool had previously captured the intrafamilial mechanisms of trauma transmission specific to the BADEP population, whose trauma lineage is rooted in slavery. The present study addresses this gap through the development and initial validation of the Survivors of Historical Intergenerational and Familial Trauma Scale (SHIFTS), a culturally grounded instrument designed to measure the transmission of historical trauma (HT) and ongoing intergenerational trauma (IGT) among Black American Descendants of Enslaved People (BADEPs). The SHIFTS examines how HT gives rise to the continued transmission of two interrelated legacies: survival-based and trauma-rooted …
Amustaline/Glutathione Pathogen-Reduced Red Cell Hemoglobin Utilization In Complex Cardiac Surgery, Ian J. Welsby, Michael E. Sekela, Edward L. Snyder, James D. Gorham, John S. Mcneil, Kathy Liu, Stanley Bentow, Thomas Gniadek, Laurence Corash, Nina Mufti, Richard J. Benjamin
Amustaline/Glutathione Pathogen-Reduced Red Cell Hemoglobin Utilization In Complex Cardiac Surgery, Ian J. Welsby, Michael E. Sekela, Edward L. Snyder, James D. Gorham, John S. Mcneil, Kathy Liu, Stanley Bentow, Thomas Gniadek, Laurence Corash, Nina Mufti, Richard J. Benjamin
Surgery Faculty Publications
Background: The ReCePI randomized, controlled trial compared amustaline/glutathione pathogen-reduced (PR) and conventional red blood cell (RBC) transfusions in cardiac surgery. Study design and methods: We performed a post-hoc analysis of hemoglobin (Hb) utilization and safety outcomes. Hb content of study RBCs was measured at manufacture. Subject Hb levels, estimated blood loss and blood product use were recorded during and for 7 days post-surgery. Acute kidney injury (AKI) incidence was graded over 7 days, and adverse events were assessed for 28 days. Results: PR-RBCs contained 5.2% less Hb (mean [SD] Test 58.1 [6.5] g; Control 61.5 [6.8] g Hb, p <.001) due to manufacturing volume losses. Four hundred fifty-six PR- and 524 conventional RBCs were transfused to 159 Test and 162 Control subjects, respectively. Mean subject baseline and post-surgery Hb levels, and blood loss were not different between groups. Test subjects tended to require fewer total RBCs (3.5 [2.7] Test vs. 4.0 [3.5] Control, p =.08) resulting in 17.6% significantly less mean total Hb transfused (Test 203.2 g; Control 246.8 g Hb, p =.01). The proportions of subjects transfused with, and the number of platelet and cryoprecipitate units transfused were not different. Test subjects received less plasma (2.3 [1.8] units Test vs. 3.5 [3.8] Control, p =.03). Overall incidence of adverse events and AKI were not clinically different. Imbalances in AKI severity (Grade III Test 15/159 [9.4%]; Control 7/162 [4.3%], p =.07) may suggest under-transfusion in the highest-risk Test subjects. Discussion: Test patients required less transfused Hb than control subjects to maintain equivalent daily hemoglobin levels following similar blood loss.
Prolonged Invasive Mechanical Ventilation Is Associated With Decreased Survival After Lung Transplantation Among Recipients With Primary Graft Dysfunction, Meghan Aversa, Shaf Keshavjee, Tereza Martinu, Marcelo Cypel, Andrew T. Sage, Joshua M. Diamond, Jonathan P. Singer, Scott M. Palmer, Krishna Pandya, Edward Cantu, Jason D. Christie, Michaela R. Anderson
Prolonged Invasive Mechanical Ventilation Is Associated With Decreased Survival After Lung Transplantation Among Recipients With Primary Graft Dysfunction, Meghan Aversa, Shaf Keshavjee, Tereza Martinu, Marcelo Cypel, Andrew T. Sage, Joshua M. Diamond, Jonathan P. Singer, Scott M. Palmer, Krishna Pandya, Edward Cantu, Jason D. Christie, Michaela R. Anderson
Surgery Faculty Publications
Introduction: Prolonged invasive mechanical ventilation (IMV) after lung transplantation is an appealing early prognostic outcome as it can be reproducibly assessed both prospectively and retrospectively. Whether use of IMV at 72 h after lung transplantation is associated with post-transplant graft survival is unknown. Methods: We performed a retrospective cohort study of 1511 participants in the multi-center Lung Transplant Outcomes Group cohort (2011–2018). Using Cox proportional hazards models and restricted mean survival time, we investigated whether IMV at 72 h was associated with post-transplant graft survival. We secondarily evaluated whether IMV at 72 h was concordant with severe primary graft dysfunction …
Mouse Models For Post-Sepsis Syndrome, John Matthew K. Ang, Stephanie F. Mori, Erick Lewis, Maria E.C. Bruno, Arnold Stromberg, Hiroshi Saito
Mouse Models For Post-Sepsis Syndrome, John Matthew K. Ang, Stephanie F. Mori, Erick Lewis, Maria E.C. Bruno, Arnold Stromberg, Hiroshi Saito
Surgery Faculty Publications
Background – Sepsis survivors commonly suffer from chronic Post-Sepsis Syndrome (PSS). To understand the mechanisms of PSS, it is critical to utilize appropriate animal models. While cecal ligation and puncture (CLP) is a widely used model of sepsis, a concern exists regarding its suitability for studying long-term outcomes. Alternatively, we previously optimized a highly reproducible murine cecal slurry (CS)-injection model of sepsis. The objective of this study was to compare the suitability of CS and CLP models for investigating PSS. Methods – Male 4-month-old C57BL/6 mice were divided into 7 groups: (1) Naïve control; (2) Sham: laparotomy control; (3) CL: …
The Federalism Canons As Ordinary Interpretation, Anthony J. Bellia, Bradford R. Clark
The Federalism Canons As Ordinary Interpretation, Anthony J. Bellia, Bradford R. Clark
Journal Articles
From the article
Scholars remain generally skeptical of substantive canons of statutory interpretation even as courts continue to employ such canons in important cases. Unlike semantic canons, which help judges discern the best meaning of statutory text in context, substantive canons provide tiebreakers when the text is unclear or require special clarity in order for the text to perform certain functions. Among the substantive canons, the so-called “federalism canons” have been singled out for special scrutiny. The federalism canons are a family of canons that require courts to avoid interpreting an act of Congress to divest states of certain sovereign …
Faces Of Formalism, Jeffrey A. Pojanowski
Faces Of Formalism, Jeffrey A. Pojanowski
Journal Articles
Formalist approaches to legal interpretation, such as textualism and originalism, are ascendant in federal statutory and constitutional law. Yet with success have come uncertainty and dissatisfaction. Formalists and their critics observe that textualism and originalism can seem as open-ended as the purposive and dynamic methods they were supposed to replace. This Article tries to diagnose the source of this discontent. It does so by identifying two different faces of formalist interpretation: the formalism of authority—adherence to original sources of law—and the formalism of method—constraint through predictable, rule-bound interpretation. Defenses of formalism often assume these two paths to constraint run together, …
Assessing Sustainable E-Cigarette Prevention Messaging In Public Health Communication, Addo Anim Adinkrah
Assessing Sustainable E-Cigarette Prevention Messaging In Public Health Communication, Addo Anim Adinkrah
Graduate Research Theses & Dissertations
This study examines the sustainability of e-cigarette or vaping prevention messaging on X (formerly Twitter) and the message-design strategies used by public health institutions to maintain message visibility over time. Using the McGuire Communication/Persuasion Model and Media Framing theoretical frameworks, the research employs a qualitative thematic analysis based on Braun and Clarke’s six-phase approach to analyze 506 tweets from official accounts affiliated with the Centers for Disease Control and Prevention (CDC) and the U.S. Food and Drug Administration (FDA). The findings reveal that prevention messages are sustained through repeated core warnings and reinforcement of institutional authority rooted in scientific and …
Symbolic Logistic Regression For Interval-Valued Predictors: A Simulation Study And Application To Health Data, Soad Abdullah
Symbolic Logistic Regression For Interval-Valued Predictors: A Simulation Study And Application To Health Data, Soad Abdullah
Graduate Research Theses & Dissertations
This thesis investigates symbolic logistic regression for interval-valued predictors through simulation studies and a real health data application. Classical logistic regression assumes exact predictor values, whereas in many practical settings variables are available only in interval form due to coarsening or reporting uncertainty. Two simulation studies examine the impact of interval uncertainty under asymmetric intervals and measurement error. Symbolic models based on midpoint and midpoint-plus-width representations are compared with the classical approach. Results show that midpoint modeling captures the general relationship but introduces bias under asymmetry, while incorporating width reduces this distortion. Under measurement error, classical logistic regression exhibits attenuation …
The Only Duck I’Ve Ever Loved Is Daffy In Drag: A Textual Analysis Of Gender Norm Reinforcement In The Looney Tunes Show, Sara Bahaji
Graduate Research Theses & Dissertations
In 2011, Warner Brother’s latest attempt to make Looney Tunes appeal to modern audiences was released, The Looney Tunes Show. This was a departure from classic Looney Tunes, from its slice-of-life sitcom setting to the changes in the characters. But one of the ways it stood out in not just classic Looney Tunes but contemporary cartoons, was its treatment of Daffy Duck. This thesis is a textual analysis of the show’s presentation of Daffy Duck’s gender. Different frameworks were used to build the analytic tools: signifying theory, as presented by Savoy (1995), gender accountability from West & Zimmerman (1987) and …
Cultural Adaptation As A Catalyst For Creativity: The Role Of Immigrant Generation And Bicultural Identity, Milena Demario
Cultural Adaptation As A Catalyst For Creativity: The Role Of Immigrant Generation And Bicultural Identity, Milena Demario
Graduate Research Theses & Dissertations
This thesis examined the relationship between bicultural identity and creative thinking among first-, 1.5-, and second-generation immigrants across a broad range of skill levels. Creativity was assessed using the Alternate Uses Task, with fluency, flexibility, and originality combined into a composite score. Results indicated that biculturalism was a strong predictor of creativity, with both cultural distance and cultural conflict positively associated with creative performance. Cultural distance showed the strongest effect, suggesting that maintaining differentiated cultural frameworks enhances divergent thinking. Mediation analyses provided partial support for biculturalism as a mechanism linking immigrant generation to creativity, primarily among second-generation immigrants. Moderation analyses …
Application Of Paper Spray Mass Spectrometry For Screening Acetylcholinesterase Inhibitors, Diksha Gautam
Application Of Paper Spray Mass Spectrometry For Screening Acetylcholinesterase Inhibitors, Diksha Gautam
Graduate Research Theses & Dissertations
Paper spray mass spectrometry (PS-MS) is a novel ambient ionization method that allows chemical and biological samples to be rapidly analyzed with little preparation being required. In this paper, PS-MS was set up and streamlined as an acetylcholinesterase (AChE)-monitoring platform in addition to screening an existing and newly produced AChE-inhibitors. The detection of the substrate, acetylcholine (m/z 146), and the AChE catalysis product, choline (m/z 104) was performed without applying chromatographic separation or derivatization to the dried paper substrates. Assay conditions were optimized in a systematic way, to develop a robust MS-compatible enzymatic workflow.
Calibration curves for both, acetylcholine and …