Digital Commons Network^™

Pneumoperitoneum As A Rare Complication Of Percutaneous Vertebroplasty: A Case Report, Chen-Ting Yang, I-Han Hsiao, Chun-Chung Chen, Der-Yang Cho, Hui-Shan Lu, Po-Fan Chiu

BioMedicine

A 70-year-old woman with a history of hepatocellular carcinoma and bone metastasis underwent percutaneous vertebroplasty for multilevel pathological vertebral compression fractures due to back pain persisting despite conservative treatment. Subsequently, she reported significant pain relief; however, on postoperative day 1, she complained of intermittent, diffuse, and severe abdominal pain. Imaging examination revealed free air in the retroperitoneum and paraspinal space, suggesting hollow organ perforation. She refused exploratory surgery and was consequently discharged against medical advice with only oral antibiotics. Two weeks later, she returned for follow-up. She was in good condition with stable vital signs and no signs of toxic …

Tracking The Course Of Fibrodysplasia Ossificans Progressiva In A Patient With The Classic Acvr1 Mutation, Mohamed Mostafa Kotb, Usama Farghaly Omar, Bishoy Raafat Zaky, Arun-Kumar Kaliya-Perumal

BioMedicine

Fibrodysplasia Ossificans Progressiva (FOP) is an extremely rare and debilitating genetic disease affecting approximately 1 in 2 million people. It is caused by a heterozygous gain-of-function mutation in the gene encoding activin A receptor type I (ACVR1), leading to dysregulated bone morphogenetic protein (BMP) signaling. Clinically, the disease features progressive heterotopic ossification, with bone forming in sites of soft tissue inflammation. We report a 7-year-old boy with two isolated ectopic bone masses in the paraspinal muscles of the neck and lumbar spine, resulting in pain and restricted spinal mobility. Genetic analysis revealed the classic c.617G>A mutation in the gene …

Neuroinflammatory And Neuronal Damage Biomarkers In Depression: A Meta-Analysis Of Hmgb1, S100Β, And Nse Levels, Ikbal Andrian Malau, Suet-Kei Wu, Jane Pei-Chen Chang, Cheng-Ho Chang, Chun-Hung Chang, Ming-Jun Tsai, Yung-Chih Chiang, Kuan-Pin Su

BioMedicine

Background: Depression is associated with neuroinflammation and dysfunction of neurons and glial cells. Immune activation and damage-associated signals such as S100 calcium-binding protein B (S100β) and high mobility group box 1 (HMGB1) amplify inflammation, leading to neuronal injury. Neuron-specific enolase (NSE) reflects such injury. These molecules may serve as potential biomarkers of depression.

Aims: This study compared levels of S100β, HMGB1, and NSE in individuals with depression versus non-depressed controls.

Methods: PubMed, Embase, and Web of Science were searched up to April 5, 2025, using the terms “S100B AND Depression”, “neuron specific enolase AND Depression”, and “HMGB1 …

Design And Development Of Novel Peptidomimetic Compounds For Cancer Therapeutics: Focus On Hsp90–Cdc37 Interaction, Sarath Perumal, Ramanathan Karuppasamy

BioMedicine

Background: The HSP90 and CDC37 molecular chaperone complex governs the

stability and function of numerous client protein kinases, making it a crucial cancer target. Given their central role, disrupting this interaction induces proteotoxic stress and inhibits tumor progression. Therapeutic peptides are the mainstay of treatment for disruption of key interactions, yet they face limitations such as toxicity, resistance, and poor stability. Aim: This study aims to leverage peptidomimetics as novel disruptors of the HSP90–CDC37 interaction. Methods: Two peptides, a 9-mer and a 7-mer, were rationally designed by analyzing key regions facilitating HSP90–CDC37 complex formation. In silico mutational analysis identified …

Evaluation Of The Anti-Inflammatory Properties In Vitro, In Vivo And In Silico, Of The Snail Slime Helix Aspersa Müller, Marouane Aouji, Malak Zirari, Mariame Taibi, Meryem Lamdak, Amine Rkhaila, Rachid Bengueddour

BioMedicine

Background: The search for effective natural alternatives to synthetic non-steroidal antiinflammatory drugs (NSAIDs), which are often associated with undesirable side effects, is an important axis of current research. The slime of the snail Helix aspersa Müller, is a traditional remedy that deserves scientific investigation for its potential therapeutic properties.

Purpose: This study aimed to comprehensively evaluate the anti-inflammatory effects of Helix aspersa Müller slime using a combination of in vitro, in vivo, and in silico methodologies.

Methods: In vitro analyses included assays for inhibition of protein denaturation, antiprotease and antilipoxygenase activities, and membrane stabilization, with diclofenac and indomethacin as reference …

Traditional Chinese Medicine And Healthcare Utilization In Bipolar Disorder: A Population-Based Study With Propensity-Matched And Mirror-Image Analyses, Shu-Ping Chen, Su-Tso Yang, Kai-Chieh Hu, Hui-Chih Chang, Jane Pei-Chen Chang, Kuan-Pin Su

BioMedicine

Background: Bipolar disorder (BD) is a chronic relapsing illness associated with high rates of acute psychiatric hospitalizations (APH) and emergency services (ES) use, placing burdens on healthcare systems. Many patients seek complementary modalities, including traditional Chinese medicine (TCM), alongside standard pharmacotherapy. However, population-based evidence regarding TCM’s effect on acute healthcare utilization in BD is lacking.

Methods: Using data from Taiwan’s Longitudinal Health Insurance Database 2000 (LHID 2000), this population-based study employed propensity score matching (PSM) based on age, gender, the index year (defined as the calendar year of the index date for TCM users and their matched nonTCM counterparts), and …

Topical Peony And Licorice Decoction Attenuates Exercise-Induced Muscle Pain: A Randomized Double-Blind Self-Controlled Trial In Taiwan, Daniel Tzu-Li Chen, Chang-Wei Hsieh, Chia-Han Tsai, Tzung-Yan Lee, Pin-Chun Chen, Pu-Wei Hou, Kuan-Pin Su, Hen-Hong Chang

BioMedicine

Background

Delayed onset muscle soreness (DOMS) is a common phenomenon that occurs after exercise training, resulting in pain and reduced muscle performance. Previous basic and animal studies have reported that oral use of Peony and Licorice Decoction (PLD), a traditional Chinese formula with anti-inflammatory and muscle-relaxing properties, may be safe and effective for DOMS. However, there have been no clinical studies, particularly on the topical use of PLD, in this field to date.

Material and Methods

Our study is a double-blind, randomized, placebo-controlled trial. We recruited healthy male athletes to assess the effect of external PLD, whose bioactive compounds were …

A Causal Association Between Alkaline Phosphatase And Natural-Cause Mortality: A Mendelian Randomization Study In East Asians And Europeans., Hung-Lin Chen, Ping-Hsun Wu, Yi-Ting Lin, Amrita Chattopadhyay, Hsiu-Yin Chiang, Yu-Ting Lin, Ya-Chi Lin, Che-Chen Lin, Min-Yu Chiang, Hung-Chieh Yeh, I-Wen Ting, Yu-Cyuan Hong, David Ray Chang, Jenq-Wen Huang, Yu-Ting Lin, Wei-Chi Syu, Tzu-Pin Lu, Yi-Chun Tsai, Fuu-Jen Tsai, Chin-Chi Kuo

BioMedicine

Background: Although observational studies show a positive association between alkaline phosphatase (ALP) levels and mortality, a causal study is not yet available.

Objective: We conducted a retrospective cohort study and a systematic one-sample Mendelian randomization (MR) study to investigate the causality of ALP on natural-cause mortality.

Methods: The study used a hospital-based cohort of Asian patients recruited from the China Medical University Hospital (CMUH) and a community-based cohort of white European participants from the UK Biobank (UKB). Two retrospective cohorts included 43,994 patients from CMUH and 80,941 participants from UKB, all aged 50–55 years, with ALP measurements. For the MR …

Tracking Toward Zero: Implementing A Picc Team Tracker To Prevent Clabsis, Christian Justin Carreon

Master's Projects and Capstones

Problem: Central line-associated bloodstream infections (CLABSIs) remain a significant and preventable patient safety concern in acute care settings, contributing to increased morbidity, mortality, prolonged hospitalization, and substantial healthcare costs.

Context: At Hospital A, a tertiary referral center in Northern California, six adult CLABSIs were identified between June and December 2025 following an eight-month CLABSI-free period. Four events occurred in adult medical surgical telemetry. All peripherally inserted central catheter (PICC) line CLABSIs were attributed to gaps in maintenance bundle adherence and the lack of a standardized, real-time tracking mechanism for the PICC Team.

Interventions: A PICC Team Tracker was implemented as …

2026 August 31 - Faculty Senate Agenda And Minutes, Faculty Senate, East Tennessee State University

Faculty Senate Agendas and Minutes

No abstract provided.

Using Clustering Techniques And Mitre Att&Ck Threat Interpretation To Detect Anomalies In Modbus/Tcp For Industrial Control Systems, Shivanjali Khare, Tirthankar Ghosh, Jhansi Sreya Jagarapu, Atharva Haridas Sagare

Journal of Cybersecurity Education, Research and Practice

Recent attacks on America's critical infrastructure have drawn increased attention on securing industrial control systems and operational technology in power plants, utility companies, and other sectors providing public services. Attack detection and mitigation strategies on these systems have shown promising results using machine learning and other statistical baselining techniques, mostly using supervised learning and classification. Unsupervised learning using cluster analysis and other techniques remain mostly unexplored. In this paper, we propose multi-layered feature extraction and hybrid clustering framework to detect fine-grained nested attack patterns in Modbus-over-TCP traffic. Operating under the assumption of known number of distinct network categories, our approach …

Between Digital Transformation And Regulatory Vacuum: Cybersecurity Of Public Services In Mozambique, Faztudo Languisse Eng.

Journal of Cybersecurity Education, Research and Practice

The rapid expansion of digital public services in Mozambique—including e-government platforms, digital health systems, and electronic tax administration—has outpaced the development of a coherent legal framework for cybersecurity. While Law No. 3/2017 (Electronic Transactions Law) of 9 January 2017 introduced foundational data-protection principles, Mozambique long lacked a dedicated cybersecurity regulatory authority, mandatory security standards, and formal incident-notification mechanisms. This regulatory vacuum exposed critical public services to escalating cyber risks as digital transformation was actively promoted as a development priority. This article examines the legal and institutional gaps in Mozambique's cybersecurity governance framework prior to the 2026 Cybersecurity and Cybercrime Laws, …

Nutrition Labeling And Food Choice Behavior In A Cross-Border Context: Evidence From The Rio Grande Valley, Edith Galy

International Business and Entrepreneurship Faculty Publications

Unhealthy dietary habits have been linked to chronic conditions such as obesity, diabetes, and cardiovascular disease. As a result, governments have implemented nutritional labeling policies intended to assist consumers in making informed food choices. While the United States relies primarily on Nutrition Facts panels, Mexico recently adopted a front-of-package warning label system that uses highly visible warning symbols. This study examines how nutritional labels influence food choices among university students in the Rio Grande Valley, a unique border region where consumers are exposed to both U.S. and Mexican food-labeling systems. Data was collected through an online Qualtrics survey administered to …

Americans For Prosperity Foundation V. Anthony Albence

2026 Decisions

USDC for the District of Delaware

Shannon Macdonald V. President Nj State Board Of Medical Examiners

2026 Decisions

USDC for the District of New Jersey

Millentine Coates V. Ford Motor Co

2026 Decisions

USDC for the District Court of the Virgin Islands

Waves Of Exhaustion, Currents Of Renewal: An Autoethnography Of Academic Emotional Burnout And Recovery, Rofiza Aboo Bakar

The Qualitative Report

This autoethnography explores my experience of academic burnout and emotional recovery as a mid-career female educator in a Malaysian public university. Drawing from reflective journals, memory work, and embodied recollections between 2023 and 2025, I trace a personal journey through three experiential phases: the weight of expectations, burnout and emotional rupture, and embodied recovery through open sea swimming. The narrative is guided by Chang’s (2016) thematic structuring approach and interpreted through Lazarus and Folkman’s (1984) Transactional Model of Stress and Coping. My story reveals how burnout was not the result of overwork, but of institutional erasure. As I navigated the …

A Post-Positivist Perspective On The Varieties Of Qualitative Research: The Foris Framework, Marius Bytautas

The Qualitative Report

With the aim of bringing clarity to the realm of qualitative research—and offering a transition from tradition to methodological rationale—I employ Millian and Popperian inductive analysis methods to build a post-positivist account regarding the diversity of qualitative research varieties. I am responding to the problem that common labels in qualitative research often obscure the epistemic reasoning through which a study approaches its object. A brief set of working definitions is introduced to support the framework, but the main contribution is the conceptualization of research approach in five dimensions: focus, orientation, relation to the object, researcher intrusiveness, and scale (FORIS). By …

Community-Based Research: Key Considerations For Researchers And Community Partners When Collaborating, Bothwell Piason, Kathleen A. Fox

The Qualitative Report

Community-based research (CBR) is a research orientation that emphasizes equitable engagement in the process of knowledge production, though researchers and community partners may navigate collaborative partnerships with differing expectations, priorities, and understandings of success. Extant research has demonstrated that successful CBR partnerships can benefit both researchers and community partners, yet little is known about how both groups simultaneously conceptualize successful collaboration across diverse partnership contexts. In this study, we ask: What considerations do researchers and community partners identify as important when engaging in community-based research partnerships? Drawing on semi-structured interviews with 10 university researchers and 10 community partners engaged in …

The Lived Spirituality Experiences Of Adult Diabetes Patients In Adhering To Treatment, Dwight Mahaputera Marulitua Hutapea

The Qualitative Report

This descriptive phenomenological study explored the lived spirituality experiences of adult patients with Type 2 Diabetes Mellitus (T2DM) in adhering to treatment. Prior research has indicated that spirituality may influence attitudes toward and adherence to chronic disease management; however, empirical evidence addressing the spiritual dimension among people with diabetes remains limited. Guided by Colaizzi's (1978) phenomenological method, in-depth interviews were conducted with 12 purposively selected participants, equally distributed among Christians and Muslims. All interviews were transcribed verbatim and subjected to rigorous phenomenological analysis. Seven themes emerged from the data analysis: (a) spirituality strengthens relationships; (b) spirituality affects choices and outcomes; …

Relational-Developmental Autoethnography: A Method Of Qualitative Inquiry That Fosters Personal Growth, Chris Wells

The Qualitative Report

This paper introduces relational–developmental autoethnography (RDA), a qualitative method for exploring psychological growth through personal writing and reflection. Developed through lived experience, RDA traces psychological development through sustained, recursive engagement with personal writing. Drawing on an archive of my journals, letters, clinical records, and correspondence spanning more than 30 years, I show how writing and reflection were first tools for my survival, and later became catalysts for insight, healing, and transformation. RDA is grounded in two developmental frameworks: Dąbrowski’s theory of positive disintegration, which views emotional intensity and inner conflict as signs of developmental potential, and relational-cultural theory, which …

Moralized Indulgence In The Age Of Inflation: How “Better-For-You” Dessert Brands Reframe Pleasure As Self-Care, Dariya Savrukova

Honors College Theses

In the modern U.S. food landscape, the line between indulgence and wellness has nearly disappeared. The booming “better-for-you” dessert industry, owned primarily by multinational giants such as Mondelēz International, PepsiCo, and Mars Inc., reframes high-sugar, high-calorie treats as acts of self-discipline or self-care. This phenomenon is often referred to as “healthwashing” (Tufts Health & Nutrition Letter, 2022), when through verbal and visual language, these companies transform indulgence into moral consumption, inviting consumers to feel virtuous through consumption. Many consumers crave stability and health, but navigate an environment saturated with manipulative design and ambiguous claims. “Better-for-you” branding exploits this gap by …

Exposing And Addressing Machine Learning Brittleness Through Constraint Solving, Muyeed Ahmed

Dissertations

Machine Learning (ML) implementations are fundamentally brittle: nondeterministic, inconsistent, and prone to overfitting; however, constraint solving can be used to systematically expose, quantify, and address this brittleness.

This dissertation first establishes that widely-used implementations of popular ML algorithms are nondeterministic (producing different outputs on the same input, across different runs) and inconsistent (different implementations of the same algorithm producing different outputs on the same input). This is more prevalent in Unsupervised Learning (UL) implementations where, due to the lack of a ground truth, subtle execution errors can go unnoticed and are difficult to verify. Nondeterminism and inconsistency also introduce security …

Engineered Porous Structures For Propellants Using Additive Manufacturing, Elbert Caravaca

Dissertations

Foamed polymers are widely used today for shock absorption and packaging materials to prevent damage to their contents. Typical foamed densities vary from 0.1 g/cm³ to 0.4 g/cm³ depending on the polymeric materials used. There is a need to explore foaming densities above 0.4 g/cm³ for propellants with highly engineered surface area progression for increased combustion performance. One way to achieve this is through highly controlled and engineered graded foam structures. To further exploit this approach, additive manufacturing coupled with a tunable means to generate foamed structures is the target of this work. To generate foam structures …

Development Of Ultrafast Protein Digestion And Standards Free Quantitation Methods For Mass Spectrometric Analysis, Praneeth Ivan Joel Fnu

Dissertations

A wide variety of biologically important molecules, such as enzymes, antibodies, hormones, transporters and receptors are proteins by composition and they play key roles in biological functions such as cellular regulation, communication, metabolism and physiological function. Protein dysfunctions and abnormalities are associated with numerous diseases, making proteins critical targets for understanding disease mechanisms and developing therapeutic interventions. Protein-based therapeutics such as monoclonal antibodies, hormones and vaccines gained popularity due to their high specificity, efficacy, and ability to treat complex diseases that are often difficult to address with small-molecule drugs.

Given the important role of proteins in a variety of biological …

The Inverse Elasto-Acoustic Problem, Patrick Grice

Dissertations

A stable and numerically efficient boundary integral method formulation of the elasto-acoustic problem is presented, based on Fourier analysis. The method generalizes well to multiple scattering. The Frechet derivative of the elasto-acoustic problem with respect to shape perturbations is derived, and geometric flow theory is used to design stable numerical methods for the simulation of moving boundaries. The shape derivative is used to define a regularized Gauss-Newton algorithm for shape fitting of elasto-acoustic scatterers.

Geographic And Environmnetal Influences On Color Pattern Similarity Between Coral Snakes (Genus: Micrurus) And Their Lookalikes, Anthony Sena

Dissertations

Venomous coral snakes and their lookalikes are often regarded as a classic example of Batesian mimicry, whereby a harmless species imitates a harmful species. The existing literature regarding coral snake resemblance presents a divisive stance on whether Batesian mimicry is the primary driver of shared color patterns or if alternative factors are responsible. While recent literature largely favors the Batesian hypothesis, empirical support remains inconsistent, and the specific geographic and interpretation of the conditions required for mimicry lacks consensus within the scientific community.

To evaluate the mechanisms maintaining these phenotypes, a quantitative, multivariate framework was utilized to analyze 400 museum …

Geometric Convergence And State-Space Decompositions For Stochastic Gradient Descent Markov Chains, Philip Zaleski

Dissertations

No abstract provided.

Solar Wind - Magnetosphere - Ionosphere Coupling Processes Through Small-Scale Magnetic Flux Ropes, Youra Shin

Dissertations

Small-scale magnetic flux ropes (SMFRs) in the solar wind are examined to determine their properties in the near-Earth upstream region and their effects on geospace. Although SMFRs are observed frequently in the solar wind, their statistical behavior near Earth and their role in solar wind-magnetosphere-ionosphere coupling remain insufficiently constrained. In this dissertation, an automated Grad-Shafranov reconstruction technique is applied to magnetic field and plasma measurements from MMS and Wind, and ionospheric responses are investigated using geomagnetic indices and SuperDARN observations. During the survey period, MMS has an apogee of approximately 25-29 R_E. This orbital configuration allows the near-Earth …

Tracking Towards Zero: Implementing A Picc Team Tracker To Prevent Clabsis, Carolina Maria Gerodias Cayetano

Master's Projects and Capstones

Background: Central line-associated bloodstream infections (CLABSIs) remain among the most serious and costly healthcare-associated infections in acute care settings, with each event associated with significant excess mortality, prolonged hospital stays, and avoidable healthcare costs. At Hospital A, a 239-bed acute care facility, two of six total CLABSI events over a 12-month period were associated with peripherally inserted central catheters (PICCs), representing 33% of all facility CLABSIs and exposing a critical gap in standardized PICC line surveillance and maintenance bundle monitoring.

Problem: The PICC team lacked a systematic, real-time tracking mechanism to monitor central line maintenance bundle adherence across seven adult …