Digital Commons Network^™

Absolute Quantification And Identification Of Rna From Rna-Lipid Nanoparticles Using High Resolution Mass Spectrometry, Jason C. Funderburk

Theses and Dissertations

RNA therapeutics are a rising drug category with potential use for a range of conditions encompassing infectious diseases to therapies for cancer, diseases, and genetic disorders. RNA-lipid nanoparticles (RNA-LNPs) are the prominent delivery method for these therapeutics approved products include mRNA vaccines and polyneuropathy treatments. The emergency use authorizations and orphan drug status of current RNA-LNP drugs has allowed approval without finalization of the regulatory analytical procedures for quality monitoring. The objective of the study was to develop an LC-MS assay to simultaneously measure identity and concentration of two therapeutically relevant intact RNA constructs extracted from RNA-LNPs to enhance quality …

Re-Sense, Nneoma Njoku

Theses and Dissertations

Re-Sense examines artist’s books as perceptual tools capable of reshaping how readers encounter history, memory, and archival absence. Beginning with the idea that books teach us how to know and how to see, the text argues that conventional book structures often reinforce Western knowledge systems through overemphasis of linearity, coherence, and containment. In contrast, artist’s books' experimental structures support novel modes of knowing and relation to ourselves and the world of humans and non-humans. The author describes this process of exhuming perception from Western constraints as re-sensing.

Through re-sensing, the historical past becomes less like a fixed record and more …

A Framework For Digital Energy Modulation And Translation In Projectional X-Ray Imaging, Richard R. Wargo

Theses and Dissertations

In projectional X-ray imaging, acquisition energy fundamentally influences subject contrast, image noise, and radiation dose. While dual-energy techniques exploit spectral differences to optimize contrast and enable material separation, acquiring multiple images of the same anatomy often requires additional exposures and increased system complexity.

This dissertation presents a framework for digital energy modulation (DEM), in which computational models are trained to translate projection images between energy domains without requiring additional X-ray acquisitions. DEM is conceived as a generalizable strategy for controlled contrast modulation in projection imaging, with potential applications in image optimization, radiation therapy alignment, and dual-energy applications.

The framework was …

Proof Of Recovery: A Model To Enhance Data Integrity In Data Management Systems, Gustaf Barkstrom

Theses and Dissertations

Businesses lose millions of dollars every year when they can’t restore data from backups. Research shows that Disaster Recovery Plan (DRP) testing is not conducted frequently enough, nor are records maintained that demonstrate full data recovery from backups. This work introduces a design science artifact called PRTOK that aims to increase DRP testing. The design science artifact is a software solution that integrates with Data Management Systems (DMS)

such as iRODS and DSpace, and can work with formats such as HDF5 and BagIt. Proof-of- recovery records, or tokens, are recorded in a replicated, resilient, and indelible proof-of- authority blockchain data …

The Impacts Of Mentoring On Mentor Teachers In A Teacher Residency Program, Eric J. Lindley

Theses and Dissertations

Teacher shortages across the United States have made educational researchers consider strategies for teacher retention. Teacher Residency Programs (TRPs) are a compelling focal area in which to study mentorship as it relates to teacher shortages and teacher retention because of their intentional preparation, development, and support for participating mentor teachers. For my dissertation study, I was interested in exploring mentors’ perceptions of their roles, relationships, and preparation as well as the impacts that mentoring had on them beyond what has already been reported in the literature. Using a qualitative interview design study approach, I conducted semi-structured interviews with 13 experienced …

In Search Of The Soul Of Creativity: Authorship, Agency, And Meaning In Refractive Collaboration With Generative Ai, Fatima Nazir

Theses and Dissertations

When images can be generated in seconds, what remains uniquely human in the act of creation? In Search of the Soul of Creativity: Authorship, Agency, and Meaning in Refractive Collaboration with Generative AI investigates where authorship, agency, and meaning reside within design practices mediated by generative AI. Rather than using AI to produce predictable results, this research deliberately relinquishes control to observe how generative systems interpret language through their own learned associations. Through a practice-led investigation across four generative models within the Higgsfield platform, user prompts were progressively shortened from full sentences to single words, revealing recurring patterns and cultural …

Follow The Cyclists: Everyday Navigation Of Richmond's Bike Infrastructure, Emily E. Schreer

Theses and Dissertations

This thesis explores the embodied experience of cycling in Richmond, emphasizing the importance of centering firsthand, lived experience in cycling research and urban planning. While traditional transportation planning can often myopically prioritize efficiency and safety metrics to evaluate infrastructure, this project argues that such approaches overlook essential experiential, sensory, and emotional dimensions of cycling that determine how infrastructure is perceived, used, and ultimately succeeds or fails.

Through an ethnographic approach combining field observation of cyclist behavior and mental mapping sessions with Richmond cyclists, this study positions people who bike in Richmond as expert knowledge holders. Participant contributions, combined with observations …

Characterization Of Microrna Expression In Neuron-Enriched Extracellular Vesicles During Early Life, Allison Molen

Theses and Dissertations

Extracellular vesicles (EVs) are membrane-bound sacs released by cells that carry molecular cargo reflective of their cell of origin. EVs enriched using L1 cell adhesion molecule (L1CAM) as a marker of putative neuronal origin can cross the blood–brain barrier and provide a minimally invasive window into brain-related processes. Exosomal microRNA (miRNA) regulate gene expression and have been implicated in psychiatric disorders, including major depressive disorder (MDD). However, measuring and analyzing miRNA from L1CAM-positive EVs presents substantial analytical challenges due to low abundance and sparse detection across samples.

Plasma samples from participants recruited through the Mid-Atlantic Twin Registry (MATR) were used …

A Qualitative Analysis Of Teacher-Report Modifications Of A Tier 2 Evidence-Based Program In Elementary Schools After Implementation Supports Are Withdrawn, Navneet Kaur

Theses and Dissertations

Growing literature emphasizes the importance of examining modifications (i.e., responses to unforeseen challenges and deliberate changes to a program) made by implementers to understand the long-term outcomes of evidence-based programs (EBPs), particularly after formal implementation supports, such as training and coaching, are withdrawn. Although prior research has documented that they occur during implementation, less is known about whether modifications occur once external supports are no longer available, and if so, what types of modifications are made, and the rationale for them. This gap is especially salient in school settings for teacher-delivered interventions. To address this gap, this study used semi-structured …

Walking And Wondering, Helen T. Tran

Theses and Dissertations

My thesis approaches walking as a form of inquiry and the Flood Wall as a site open to reinterpretation. I believe that the way we walk changes the way we observe and experience the world around us. This contrast between purposeful and leisurely walking reveals how time and intention shape our awareness of space. When walking is no longer dictated by urgency, it invites observations and questions. Slowing our pace allows curiosity to emerge, which aligns with my design ethos of asking questions as a foundation for understanding and creating meaningful experiences.

The Flood Wall’s emphasis on uninterrupted movement prioritizes …

Nanomagnet Based Straintronic Devices For Unconventional Computing: Simulation And Performance Analysis, Rahnuma Rahman

Theses and Dissertations

Nanomagnetic devices are of great interest in digital hardware because of their non-volatility and dynamic ability to change magnetization but suffer from high switching error rates and temperature sensitivity. Magnetostrictive nanomagnets that utilize strain to switch between stable magnetization states encoding bit information are of interest since they are extremely energy efficient as piezoelectric layers can be used to rotate magnetization that have switching energies in the range of attojoules. Their stochasticity can also be useful in probabilistic, analog, neuromorphic, and collective computing systems, where occasional switching errors are not devastating. The dissertation extends spintronics beyond conventional computing schemes by …

Commissioning & Daily Qa Of Converted Linac For Electron Flash, Tomaj Javidtash

Theses and Dissertations

Ultra-high dose rate (FLASH) radiotherapy has demonstrated promising normal tissue sparing in preclinical studies; however, the lack of standardized dosimetry, commissioning, and quality assurance (QA) methodologies remains a major barrier to its reproducible and safe implementation. In particular, conventional clinical commissioning and QA protocols are not directly applicable at FLASH dose rates due to challenges associated with detector response, dose-per-pulse effects, and beam control limitations.

This thesis presents the commissioning of a converted Varian 21EX linear accelerator for electron FLASH operation within the Division of Medical Physics at the Virginia Commonwealth University (VCU) Department of Radiation Oncology. Comprehensive beam characterization …

Within The Ruin: A Modern Brewery Rebirth, Karim Asarzadeh

Theses and Dissertations

This thesis project focuses on the revitalization of the historic ruins of the James River Steam Brewery in Richmond, Virginia. The project transforms the forgotten industrial structure into a modern brewery with a second-floor restaurant addition and community gathering spaces while preserving the historic masonry ruins. It showcases a holistic design approach that considers all aspects of the building, including its connection to the urban context and landscape, as well as its architecture, interiors, and furniture. The project demonstrates how a holistic design approach can create stronger spatial connections and more cohesive environments. In particular, it offers a strategy for …

Exploring, Understanding, And Supporting Academic Help-Seeking In Context, Molly L. Taylor

Theses and Dissertations

Conceptualized as a self-regulated learning (SRL) strategy, academic help-seeking is a fascinating behavior because it is self-directed while also reliant on social interactions with help-givers (Karabenick, 2004). What is known about help-seeking in academic settings largely revolves around individual traits, strategies, motivations, beliefs, and identities, and how each of these constructs influence help-seeking outcomes (Bornschlegl et al., 2020; Fong et al., 2023; Karabenick & Gonida, 2018). What is underexplored in these areas, however, is how features of the learning context interact with student-level factors to shape academic help-seeking behaviors and beliefs. This dissertation attempts to address some of these gaps …

The Effects Of Overwash On Barrier Island Evolution And Building A Barrier Island Measure Of Resistance, Beth Thomas

Theses and Dissertations

Barrier islands are critical for coastal communities, as they serve as a natural buffer against storm surge, waves, and the effects of rising sea levels, protecting life and property. These islands continuously evolve due to both normal and severe environmental conditions; global warming makes it increasingly difficult to predict the evolution of these islands due to increases in storm frequency and intensity. We present a cellular model of barrier island evolution consisting of biotic and abiotic processes including the effects of vegetation, wind, ocean currents, and gravity. The model is used to predict the future evolution of barrier islands off …

In-Between Echoes, Jiayi Liang

Theses and Dissertations

In this dissertation, I explore memory, diaspora, labor, and intergenerational trauma through constructed photography and experimental film. Informed by Homi K. Bhabha’s concept of the Third Space, I examine how identity is shaped through displacement, cultural negotiation, and inherited memory. Drawing from my relationship with my grandmother and my experience as a Chinese woman living in diaspora, I consider labor as both survival and care, tracing how domestic gestures and emotional structures continue across generations. Through collage, reconstruction, and animation, I rework fragments of family archives, colonial landscape imagery, and personal photographs to address grief, racialized perception, belonging, and the …

Profile: More Is Morris, Communications And Marketing

Profile (1996-)

In this Issue: New Name and New Director for the AgCountry Challenge ; Salute to Scholarships ; Gift to Not Only Enhance Cougar Sports Center But Entire Community ; Lucy Imholte's Lasting Legacy Honored Through Sculpture ; From Dining Hall to Third Floor Behmler: Rodriguez '87 is Eighth Chancellor ; Partnership Pilots New Energy Storage Technology on Campus ; Faculty and Staff Awards ; Van Wey Named Fulbright Finalist ; UMN Morris Receives Carnegie Community Engagement Classification ; Public Lecture, Telescope Viewing Part of SCOPES Conference ; UMN Morris Adds $165.3 Million to Minnesota's Economy Each Year ; PBS Documentary …

Nest Eggs And Lifelines: The Overlooked Strain Of Economic Volatility On 401(K) Participants, Samantha Prince

Faculty Scholarship

Many Americans rely on defined contribution plans like 401(k) plans for retirement savings. These plans do not guarantee a fixed retirement benefit; rather, the benefit is based on accumulated contributions and investment performance. When the stock market drops, so do retirement account balances. When inflation hikes living expenses, money does not go as far. President Donald Trump's policies, including those associated with tariffs, are causing economic and resource volatility leading to financial hardship. Americans worry as they watch living costs increase and their retirement savings diminish. It is well known that retirees rely on 401(k) plan balances to fund their …

Embracing Imperfection And Stress As The Foundation For Growth, Excellence, And Well-Being In Dentistry, John W. Claytor Jr., Dds, Magd-Llsr, Facd

Journal of the American College of Dentists

Studies reveal that stress in dentistry begins early in training and may progress throughout a dentist’s career. Fear of managing patient dissatisfaction, demanding schedules, time constraints, staff issues, and the stressors of clinical dentistry all contribute to professional strain. Difficulties associated with perfectionistic tendencies, burnout, and mental health concerns remain ever-present challenges within the profession. This article discusses evidence-based strategies, coping skills, organizational approaches, and professional resources that may help mitigate the effects of stress in dentistry. Particular emphasis is placed on reducing stigma surrounding mental health care and supporting initiatives such as the Lorna Breen Heroes Foundation’s “Safe Haven” …

Revisiting Nasal Polyp Scoring In Clinical Trials: Interpretive Variability And The Need For Standardization, Leigh J. Sowerby, Babak Pourmomenarabi, Antonino Maniaci, Olivia Ginty, Joseph Khristian Han

Department of Otolaryngology (ENT) Faculty Publications

[Introduction] Borish et al. provided an excellent review highlighting methodological variability among the six pivotal Phase III trials [1]. One critical yet overlooked issue is the inconsistent application of the endoscopic nasal polyp score (NPS), a primary outcome measure in all trials.

Oropharyngeal Syphilis Presenting As Tongue Based Ulcer With Lymphadenopathy, Serena F. Pu, Kevin J. Carlson, Jonathan R. Mark, Benjamin J. Rubinstein

Department of Otolaryngology (ENT) Faculty Publications

Within the aerodigestive tract, syphilis presents with varied signs and symptoms, some of which may mimic malignancy or other disease processes. We present the case of a 29-year-old man with otalgia and odynophagia who was found on physical examination and office laryngoscopy to have a 4-cm ulcerative mass of the tongue base and cervical lymphadenopathy. While planning for tissue diagnosis, the patient’s serologies revealed positive treponemal antibody testing and elevated rapid plasma reagin (RPR) titers, confirming syphilitic infection, likely representing secondary syphilis. While awaiting operative biopsy, the patient received intramuscular penicillin with complete resolution of the mass and symptoms, and …

Dupilumab In Chronic Rhinosinusitis Without Nasal Polyps: Randomized Phase 2 Trial (Orion), Stella E. Lee, Anju T. Peters, Philippe Gevaert, Joseph K. Han, Claus Bachert, Francisco Moreira Da Silva, Andrés Rosenblüt, Chih-Chi Hu, Jennifer Maloney, Paolo Caferra, Adrianna Michalak, Andrew P. Fontenot, Lacey B. Robinson, Neelam A. Phadke

Department of Otolaryngology (ENT) Faculty Publications

BACKGROUND: Chronic rhinosinusitis (CRS) is often driven by type 2 inflammation and is characterized by nasal obstruction/ discharge, facial pain/pressure, and/or reduced smell, either with or without nasal polyps (CRSwNP or CRSsNP).

OBJECTIVE: To test whether dupilumab improves radiographic features in CRSsNP. Methods: ORION (NCT04678856), a phase 2, randomized, multicenter, double blind, placebo-controlled study, assessed dupilumab efficacy and safety in adults with uncontrolled CRSsNP. Patients were randomized 1:1 to dupilumab or placebo for 24 to 52 weeks. Endpoints included changes from baseline at week 24 in Lund–Mackay computed tomography (LMK-CT) score (dupilumab only [primary] and vs placebo [secondary]), sinus Total …

Development Of Dashboards And Procedures For Using Connected Vehicle Data To Prioritize Investments In Electric Vehicle Related Infrastructure, Jairaj C. Desai, Nathaniel J. Sturdevant, George Mccue, Darcy M. Bullock

JTRP Technical Reports

The National Electric Vehicle Infrastructure (NEVI) Formula Program and the Charging and Fueling Infrastructure Discretionary Grant Program together provide $7.5 billion to support states with building out a nationwide EV charging network. Indiana’s Charging the Crossroads program, funded through the NEVI program, plans to invest almost $100 million to build an EV charging network along Indiana interstates and highways. There is broad consensus among states, that these fast charging station investments should be based upon quantitative geospatial data with the objective of maximizing the impact of the NEVI program investments.

However, traditional methods for monitoring electric vehicle (EV) usage have …

Portable Driving Simulation Platform For Innovative Intersections, Luyang Jiang, Zihao Li, David Chen, Blake Edwards, Angel Rivera Cardenas, George Takahashi, Brandon Pitts, Ziran Wang

JTRP Technical Reports

This report presents a portable driving simulation platform developed to improve public understanding and evaluation of innovative intersection designs. Built in Unity, the system integrates real-world roadway data with modular traffic and vehicle simulation to create realistic, interactive driving scenarios. Results show the platform effectively supports driver learning and stakeholder engagement, demonstrating its feasibility as a tool for education, safety analysis, and deployment support of innovative intersections.

Parkland's Beginnings, 1966-1986 (Exhibit Materials), Donica Swann

Library Scholarship

2026 marked Parkland College's 60th anniversary. This exhibit explores Parkland's beginnings with a focus on the college's creation, classes offered, and the first students to enroll.

Embodied, Relational, And Rooted: A Social Work Portfolio, Deneen Pancari

Graduate Student Portfolios, Professional Papers, and Capstone Projects

This portfolio reflects my professional and personal growth over the past three years of the University of Montana!s (UM!s) Online Master of Social Work (MSW) Program and showcases my understanding of advanced social work competencies (University of Montana School of Social Work, n.d.). My background includes yoga facilitation and preschool education, where I developed a strong appreciation for early childhood development and mindfulness. I never imagined how this path would lead me into clinical work in eating disorder recovery, adolescent therapy, and somatic-based interventions, which focus on the connection between the mind and body. My MSW coursework and practicum experiences …

Practicing From The Inside Out: A Portfolio Of Trauma-Informed And Spirit-Led Social Work, Cailey R. Denboer

Graduate Student Portfolios, Professional Papers, and Capstone Projects

This portfolio represents the integration of academic learning, practicum experience, and personal growth throughout my Master of Social Work education at the University of Montana. Grounded in empowerment theory, trauma-informed care, and anti-oppressive practice, this work reflects my commitment to ethical, culturally humble, and relational social work across individual, community, and organizational contexts. Drawing from coursework and practicum experiences, I highlight the development of core competencies through applied work.

A central theme of this portfolio is the ongoing process of self-reflection and humility, particularly in recognizing areas of growth and navigating the tensions between personal values, professional responsibilities, and systemic …

A Chromosome-Level Assembly And Functional Genomic Resources For The Model Annelid Capitella Teleta, Billie E. Davies, Paul Gonzalez, Abhinav Sur, Jingcheng Wei, Tom Frankish, Jimena Montagne, Allan M. Carrillo-Baltodano, Kero Guynes, Yan Liang, Rory D. Donnellan, Travis Moreland R., Sumeeta Singh, Suiyuan Zhang, Reynold Yu, Tyra G. Wolfsberg, Néva Meyer, Elaine C. Seaver, Andreas D. Baxevanis, José M. Martín-Durán

Biology

The polychaete Capitella teleta is a primary model for evolutionary developmental biology, comparative genomics, conservation, and ecotoxicology. Although it was the first polychaete genome sequenced, the original assembly is outdated by modern standards. Here, we combine long-read and short-read sequencing with Hi-C chromatin conformation capture to assemble chromosome-level nuclear and mitochondrial genomes of the laboratory strain of C. teleta. This reference assembly accurately reflects the expected genome size (∼243.6 Mb) and contains a highly complete, evolutionarily conserved gene repertoire. Notably, the nuclear and mitochondrial genomes are heavily rearranged, indicating a decoupling between gene family repertoire and chromosomal evolution. The analyses …

Embedded Tense And The Problem Of Acquisition, Sam Alxatib, Spencer Caplan

Publications and Research

What we hope to do is pose questions that, to our knowledge, have not received attention in the literature. The broad form of the question is all too familiar: how do speakers of a language—say, English—come to possess the grammatical knowledge that they demonstrate? The questions that guide this paper are narrow instances of this broad one, narrowed in three ways. First, they concern three particular languages: Japanese, English, and Russian. Second, they concern tenses specifically, and more specifically still, constructions containing embedded tenses. Third, they concern the semantics of tense. The learning challenge of interest to us is not …

General Education Teachers' Perceptions Of Emotional Impairment, Ivy Smith

Brehm Scholars Research

Roughly 67% of students with disabilities spend 80% or more of their day in a general education setting (National Center for Education Statistics, 2024). This can be challenging for general education teachers as they do not receive the same level of training on disabilities as special educators, leading to struggles with students with behavioral difficulties and Emotional Impairment. This study surveyed Michigan general educators’ to assess their understanding of Emotional Impairment eligibility as written in the Michigan Administrative Rules for Special Education (MARSE). Results from a survey completed by 16 participants were derived through descriptive statistics and inductive content analysis. …