Digital Commons Network^™

Brief Pulses Of High-Level Fluid Shear Stress Enhance Metastatic Potential And Rapidly Alter The Metabolism Of Cancer Cells, Amanda N. Pope, Devon L. Moose, Guy O. Hudson, Hank R. Weresh, Marion R. Dykstra, Aabha Y. Joshi, Patrick Breheny, Eric B. Taylor, Michael D. Henry

Department of Biomedical and Translational Sciences Faculty Publications

Circulating tumor cells (CTCs) face challenges to their survival, including mechanical and oxidative stresses that are different from cancer cells in solid primary and metastatic tumors. The impact of adaptations to the fluid microenvironment of the circulation on the outcome of the metastatic cascade is not well understood. Here, we find that cancer cells exposed to brief pulses of high-level fluid shear stress (FSS) exhibit enhanced invasiveness and anchorage-independent proliferation in vitro and enhanced metastatic colonization/tumor formation in vivo. Cancer cells exposed to FSS rapidly alter their metabolism in a manner that promotes survival by providing energy for cytoskeletal remodeling …

Stat4-Dependent Regulation Of Neuroinflammation In Atherosclerosis, Natalie Stahr, Alina K. Moriarty, Shelby D. Ma, W. Coles Keeter, Woong-Ki Kim, Larry D. Sanford, Elena V. Galkina

Department of Biomedical and Translational Sciences Faculty Publications

Atherosclerosis is linked to an increased risk of cognitive decline, with chronic inflammation being a common feature of both pathologies. IL-12 activates STAT4 to regulate myeloid cell functions, and blockade of this pathway alleviates cognitive impairment in Alzheimer's models. However, the mechanisms connecting vascular pathology to neuroinflammation remain unclear. Here, we examine whether STAT4 functions as a common mediator of neuroinflammation in atherosclerosis. We demonstrate that LysM^Cre-specific STAT4 deficiency ameliorates deficits in long-term memory in low-density lipoprotein-deficient (Ldlr^-/-) mice fed a high-fat diet (HFD-C). STAT4 deficiency moderately reduces Ser199-phosphorylated Tau burden. Atherosclerosis alters brain immune …

Cocaine Upregulates Microglial Lipid Droplet Formation Through Increasing Lipid Synthesis Activity In Vitro And In Vivo, Yan Cheng, Brooke Russell, Liam Liyang Guo, Aryan Patel, Yan Y. Sanders, Ming-Lei Guo

Department of Biomedical and Translational Sciences Faculty Publications

A novel subtype of microglia, lipid droplet accumulation microglia (LDAMs), has been identified in the aged brain, which is characterized by sustained inflammation and senescent-like phenotypes. LDAMs are deeply involved in promoting brain aging as well as the pathogenesis of multiple neurodegenerative diseases. Cocaine can alter brain lipidomic profiles, induce microglial activation, and accelerate brain aging. This suggests that cocaine might affect microglial lipid metabolism, which ultimately aggravates aging-related neurological disorders in people with addictions. In this study, we explored the effects of cocaine on microglial lipid metabolism. Our results showed that chronic cocaine administration altered brain lipid profiles and …

The Effects Of Abused Drugs On Ferroptosis Pathways: Potential Therapeutic Targets For Substance Use Disorders, Tamara Bouchard, Brooke Russell, Liam Liyang Guo, Tina Nguyen, Yan Cheng, Yan Y. Sanders, Ming-Lei Guo

Department of Biomedical and Translational Sciences Faculty Publications

Substance use disorders (SUDs) remain major public health concerns worldwide, particularly in developed countries. SUDs are characterized by persistent neuroinflammation and synaptic dysfunction in the brain. Despite decades of extensive investigation, the detailed mechanisms underlying SUDs remain elusive. Ferroptosis is a highly regulated cell death process deeply affected by iron metabolism, lipid peroxidation, reactive oxygen species (ROS) production, and antioxidant systems. It has been implicated in multiple neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, multiple sclerosis, and ischemic stroke. Recently, emerging evidence has highlighted the role of ferroptosis in drug-induced pathological changes. Various types of abused …

The Effects Of Abused Drugs On Ferroptosis Pathways: Potential Therapeutic Targets For Substance Use Disorders, Tamara Bouchard, Brooke Russell, Liam Liyang Guo, Tina Nguyen, Yan Cheng, Yan Y. Sanders, Ming-Lei Guo

Department of Biomedical and Translational Sciences Faculty Publications

Substance use disorders (SUDs) remain major public health concerns worldwide, particularly in developed countries. SUDs are characterized by persistent neuroinflammation and synaptic dysfunction in the brain. Despite decades of extensive investigation, the detailed mechanisms underlying SUDs remain elusive. Ferroptosis is a highly regulated cell death process deeply affected by iron metabolism, lipid peroxidation, reactive oxygen species (ROS) production, and antioxidant systems. It has been implicated in multiple neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, multiple sclerosis, and ischemic stroke. Recently, emerging evidence has highlighted the role of ferroptosis in drug-induced pathological changes. Various types of abused substances including alcohol, cocaine, …

Expert Consensus On Osteoporosis Risk Management In Patients With Sleep Disorders, Siqi Leng, Jinming Yang, Yuming Jin, Jie Shi, Ye Zhang, Junying Zhou, Lusi Tan, Taomei Li, Peiyan Ni, Kejia Hu, Yuan Shi, Jiamin Liao, Yun Li, Pei Xue, Christian Benedict, Alexandros N. Vgontzas, Michael Furian, Talant Sooronbaev, Naima Covassin, Virend K. Somers, Zhoulong Yu, Hongqiang Sun, Xiao Tan, Jihui Zhang, Yun Kwok Wing, Yue Leng, Larry D. Sanford, Michael V. Vitiello, Katie L. Stone, Rong Ren, Lin Lu, Xiangdong Tang

Department of Biomedical and Translational Sciences Faculty Publications

A rate-limiting step in the prevention and early intervention of osteoporosis is identifying its asymptomatic onset. Accumulating evidence shows that sleep disorders are associated with an increased risk of osteoporosis. Given their early detectable and modifiable nature, integrating sleep disorder management into osteoporosis prevention and care pathways offers a novel approach for enhancing skeletal health. This expert consensus represents a collaborative effort by specialists in sleep medicine and orthopedics from across the world, integrating epidemiological, mechanistic, and interventional evidence to provide general guidance for prevention and clinical practice, and to foster multidisciplinary collaboration in the management of sleep disorders and …

Does Textualism Constrain Supreme Court Justices?, James J. Brudney, Lawrence Baum

Faculty Scholarship

A principal justification for textualism is the constraint hypothesis. Conservative Justices and leading textualist scholars contend that—in stark contrast to reliance on legislative history—focus on the ordinary meaning of enacted text leaves little room for the Justices to be policy-oriented or ideological in their interpretations. This Article represents the first systematic study probing the validity of the constraint hypothesis, one that employs both quantitative and qualitative analysis.

The Article examines the Justices’ reliance on interpretive resources in over 660 statutory decisions in the field of labor and employment, decided by the Burger Court, the Rehnquist Court, and the Roberts Court—during …

Cross-Cultural Communication Challenges In Multicultural Hospitality Teams: A Case Study Of The Arlington Hotel, Dublin, Lorrana Rosendo Da Silva

Business ETD Collections

This study investigates intercultural communication challenges within multicultural teams in the hospitality sector in Dublin, focusing on how linguistic barriers, cultural expectations and the dynamics of subgroups influence staff collaboration and day-to-day coordination. The research employs a qualitative case study at the Arlington Hotel, utilizing four semi-structured interviews—two with managers and two with employees—analyzed using thematic analysis. The findings indicate that, particularly during periods of high operational pressure, differences in English proficiency and understanding of accents can affect the clarity of instructions and the confidence to seek clarification. Furthermore, subgroups based on language or nationalities were described as useful in …

Analysis Of Employee Retention In The Irish Hospitality Sector, Ali Okan Yazicioglu

Business ETD Collections

This study investigates the organisational and external labour market factors influencing employee retention in the Irish hospitality sector. The sector faces persistently high turnover rates, yet existing literature has largely focused on internal factors such as leadership and working conditions, overlooking broader labour market dynamics. To address this gap, a qualitative research design was adopted, involving semi-structured interviews with six participants (three managers and three kitchen staff) working in hospitality establishments in Dublin’s Temple Bar area. Thematic analysis was applied to identify key themes related to working conditions, management practices, job satisfaction, employee retention, and labour market factors. The findings …

Key Factors Influencing Consumer Booking Decisions On Booking.Com, And The Role Of Trust In Online Reviews, Deisiane Soares

Business ETD Collections

This study examines the factors influencing accommodation booking decisions on Booking.com, with a particular focus on the role of trust in online reviews. Using a quantitative survey, the research analyses how consumers evaluate key factors such as price, location, ratings, and user-generated reviews. The findings show that while online reviews help reduce uncertainty and build trust, they are not the main driver of booking decisions. Instead, price and location are the most influential factors, with trust in reviews acting as a supporting element. Trust is also found to be conditional, depending on review consistency, detail, and recency. Hence, the study …

Exploring The Challenges Faced By Home Care Workers In Dublin, Camila Melo Dos Santos

Business ETD Collections

This study explores the challenges faced by home care workers employed by private healthcare providers in Dublin, and how the workers perceive the training and organisational support available to manage job demands. Using a mixed methods approach, quantitative data was collected through a survey that received 24 responses, and qualitative data from four in depth interviews. The findings identify time pressure as the most significant challenge, and discovered that formal training is available but it is not considered relevant by the workers, who rely on their experience to deliver the service. Organisational support was perceived as inconsistent, with lack of …

Member Engagement And Retention Challenges In The Latin Cycling Club Dublin, Sarideth Ailin Solis Lopez

Business ETD Collections

This study investigates participant engagement and retention challenges at Latin Cycling Club Dublin, a volunteer-run, non-profit community cycling group based in Dublin, Ireland. The group brings together Spanish-speaking people and others interested in Latin culture who ride together for hobby, social connection, and health improvement. Despite having 259 Instagram followers, 125 Strava participants, and 112 WhatsApp group members, only 8 to 12 people join rides on a regular basis, representing a drop-off of approximately 90 to 93%. The same small core group attends most rides, while the majority of followers remain inactive. Female participation is below 10%, and non-Spanish speakers …

The Impact Of Multicultural Staff On Service Performance And Customer Loyalty: Evidence From A Dublin Beauty Spa, Paulina Veronica Flores Lopez

Business ETD Collections

The present research explores the relationship between multicultural staff service performance and loyalty within the context of a beauty spa in Dublin. The investigation focuses to understanding how employee cultural diversity affects customer experience and service delivery in a highly interactive service scenario.

A quantitative research methodology was adopted, based on survey information collected by 50 clients and 25 employees. Key variables, including employee performance, intercultural communication, Human Resources practices, customer satisfaction, and customer loyalty, were analysed using descriptive statistics. Additionally, the interpretation of the results was supported by the analysis of qualitative insights from open-ended responses.

The findings show …

Adapting International Marketing Strategies To Local Markets: A Case Study Of Zambrero In Ireland, Júlia Megale Freitas Pimenta

Business ETD Collections

As companies expand into increasingly globalised markets, they face the strategic challenge of balancing global standardisation with responsiveness to local market needs. This study examines how the balance between standardisation and local adaptation influences customer perception in the international fast-casual food sector. While standardisation can provide economies of scale, operational efficiency, and consistency in global brand identity, adaptation allows companies to respond to differences in consumer preferences, cultural expectations, and competitive conditions. Drawing on international marketing and branding literature, the study considers how these strategies influence perceptions of brand identity, authenticity, value, and customer loyalty across different national markets. Particular …

Country-Of-Origin Cues And Indian Consumers’ Skincare Purchase Intention: A Research Proposal For Reliance Retail’S Tira Beauty, Mohammed Ismail Shareef

Business ETD Collections

This study investigated how Indian consumers perceive the "country-of-origin" (COO) cue when evaluating skincare products from Tira Beauty. Specifically, this study focused on COO for both Indian-origin and foreign-origin skincare to determine if there is a link between origin, consumer trust in brands, attitudes toward brands, and intentions to make purchases. Using a qualitative methodology and three semi-structured online zoom interviews with Indian consumers who are familiar with Tira Beauty, the study identified themes within the interview responses and analysed them using manual thematic analysis in Microsoft Excel. Results indicate that COO influences initial perceptions of products; however, it does …

“I Don’T Always See A Future For Me Here”: Oppressive Political Pressures On Lgbtq+ College Students’ Well-Being, Jodi Linley, Olivia M. Copeland, Kathleen J. Buell, Cindy Ann Kilgo, Megan Pendleton, Alex C. Lange, N F. Tennessen

Journal of Queer and Trans Studies in Education

In recent decades, colleges have broadly supported LGBTQ+ students. Now, institutions have shuttered LGBTQ+ initiatives in response to political pressures, with little consideration for the effects on students. This study answers the question, what current policy factors do LGBTQ+ college students describe as affecting their well-being, and in what ways? We analyzed 426 responses from a multi-institution study of LGBTQ+ students. By and large, students feel anxious and fearful as they navigate the current climate. Our analysis illustrated numerous factors, from the President and his administration to states and general emboldened violence, and the real and potential consequences of those …

The Law Of Quitting, Andrew K. Jennings

Faculty Articles

Throughout life, people enter countless positions of authority and trust in relation to one another and the public. These positions include, among many others, being a public official, being a corporate director, and being an employee. Law announces prerequisites for starting such positions, as well as incumbents’ rights and obligations once in them. But no office holds forever. Indeed, incumbents often choose to exit positions before they would otherwise end by expiration, removal, or death. Yet law governs such voluntary relinquishment—often called “resignation” or, more generically, “quitting”—largely as afterthought. That is, law expansively attends how positions of authority and trust …

Applying Transfer Learning For Street-Scale Nuisance Flood Forecasting In Coastal-Urban Environments, Binata Roy, Jonathan L. Goodall, Diana Mcspadden, Chetan Kumar, Steven Goldenberg, Yidi Wang, Malachi Schram

Data Science Faculty Publications

An important challenge with Machine Learning (ML) is its transferability; that is, whether an ML model trained on one set of data can be applied to a second set of data without requiring full retraining of the model. Transfer Learning (TL) addresses this challenge by transferring knowledge learned in the source domain (the data it was trained on) to the target domain (a second set of data that is statistically different but related, which the model was not trained on). This study investigates the use of TL for street-scale nuisance flood forecasting by exploring whether an ML model trained for …

Managing Deportation: How Docket Control Replaced Substantive Relief In Immigration Courts, R. Linus Chan

SMU Law Review

In the modern deportation era, immigration courts saw their ability to grant relief from deportation undergo significant restrictions, constraining individualized discretion in favor of "categorical" denials. Congress dramatically curtailed the discretionary tools available to immigration judges, with the latest being the pair of immigration reforms from 1996, shifting the locus of individualized decision-making away from the courts and toward enforcement officers and prosecutors. Immigration courts lost discretion in being able to decide who could formally be granted status and stay in the United States when facing deportation through various restrictive eligibility requirements written into the law.

This Article argues that …

Fda After Loper Bright, Erika Lietzan

SMU Law Review

Loper Bright Enterprises v. Raimondo, which overruled the Chevron, U.S.A. v. Natural Resources Defense Council decision from 1984, tells us that a court should determine the meaning of all statutory provisions for itself, rather than deferring to the views of the federal agencies that implement those provisions. But the overruling of Chevron may have less of an impact on the U.S. Food and Drug Administration (FDA) than conventional wisdom supposes. Most challenges to FDA action do not concern its statutory interpretations. And the agency prevailed in most cases involving statutory interpretation before the Chevron doctrine took hold. After 1984, …

The Effects Of A Teacher-Led Coaching Intervention On Paraprofessionals’ Rates Of Behavior-Specific Praise In Secondary Special Education Classrooms, Melanie Urmilla Singh

PCOM Psychology Dissertations

The role of paraprofessionals in education is essential as they work alongside teachers to provide additional support to students within classrooms. Their responsibilities may differ based on the needs of the school, classroom, and student, paraprofessionals often play an important role in supporting students’ behavioral needs. While their roles being prevalent in education, paraprofessionals could benefit from additional training in evidence-based strategies, specifically when working with students with behavioral needs and the application of behavior-specific praise. Considering that teachers typically receive more formal training and work closely with paraprofessionals in the classroom, they are well positioned to provide training support …

Social Drivers Of Healthcare Access In Pediatric Autoimmune Disease: A U.S. Analysis (2022–2023), Kevin Okifo

Yale Medicine Thesis Digital Library

Background: Prior studies in adults have demonstrated that social drivers of health contribute to disparities in disease burden, management, and healthcare access among individuals with autoimmune disease (AD). There is emerging pediatric evidence suggesting similar patterns, but national-level data describing how social and structural factors shape healthcare access for children with AD remain limited. The aim of this study is to identify the sociodemographic and structural factors associated with healthcare access among children and adolescents with AD in the United States. Understanding these factors can support meaningful advances that will optimize patient-centered care and wraparound services for pediatric AD.Study Design: …

Health Communication Challenges In The Digital Era: Two Empirical Investigations, Neeraj Gautam Patel

Yale Medicine Thesis Digital Library

Background: The quality and availability of health information consumed by the general public have undergone dramatic changes in the 21st century with the rise of digitization and the internet. These include the growth of direct-to-consumer (DTC) advertising of prescription drugs on television and online media, changes in health content on traditional news media platforms, and the propagation of health misinformation and disinformation on social media and other websites. Understanding the nature and sources of these changes can inform efforts and interventions aimed at improving the general public’s understanding of health information. One area of interest within regulated health communication is …

The Bridwell Quarterly, Issue 30 Winter 2026, Anthony Elia, Michelle S. Ried

Bridwell Library Publications

No abstract provided.

Index To Peacock, Bonnie Petry

Peacock – John M. Pfau Library Newsletter

When Using This Index:

Until the Spring 2017 issue, there were no page numbers in the newsletter.  Also, digitization adds a cover page.  Therefore, Adobe Acrobat-supplied page numbers were used in this index for the years 1997-2017.

From the Spring 2017 issue to the present, Peacock’s own page numbers have been used.

This index first compiled by Bonnie Petry in 2026.

Rurality, Infant Feeding Practices, And Perinatal Cardiovascular Health Behaviors, Elly Marie Marshall

Graduate Theses, Dissertations, and Problem Reports (ETD)

Introduction: Cardiovascular diseases are a leading cause of pregnancy-related deaths in the United States, with higher rates in rural areas. While limited healthcare access contributes to this disparity, other factors remain unclear. Breastfeeding provides long-term protection against cardiovascular disease, but modern infant feeding practices are complex and may impact maternal cardiovascular health (CVH) in unexpected ways. Healthy CVH behaviors of sufficient sleep duration, adequate physical activity, a healthy diet, and nicotine avoidance can enhance protection against future cardiovascular disease risk. Therefore, the aims of this dissertation are to 1) assess associations between rurality and first trimester CVH behaviors; 2) synthesize …

Preoperative Patient Sentiment Is Associated With Postoperative Outcomes In Adult Spinal Deformity Surgery, Ross J. Gore, David Mazur-Hart, Mohan K. Sunkara, Aaqib Ali, Qizar Ali, Christopher J. Lynch, Christopher Ames

Center for Secure and Intelligent Critical Systems (CSICS) Publications

Study Design: Prospective observational pilot study of adult spinal deformity surgery patients.

Objective: To determine whether preoperative patient sentiment, quantified using a 21-class valence scale extending the CARP paradigm implemented through an offline Large Language Model, predicts postoperative outcomes.

Summary of Background Data: Predicting adult spinal deformity surgery outcomes remains challenging with traditional clinical and radiographic parameters alone. Although patient psychological factors and expectations significantly influence postoperative satisfaction and quality of life, systematic approaches to capture these factors are underdeveloped. Offline Large Language Models offer scalable, privacy-preserving psychological risk stratification.

Materials and Methods: We prospectively enrolled 18 patients undergoing adult …

Promoting The Use Of Smoke Evacuation Systems In The Operating Room: A Quality Improvement Initiative, Andrea Leigh Drayer

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background: Surgical smoke produced during procedures poses serious health risks to operating

room (OR) staff and patients, yet many hospitals, including an academic medical center in

northern West Virginia, have underutilized smoke evacuation systems. The imminent

enforcement of West Virginia House Bill 4376, mandating smoke evacuation use, provided both

urgency and opportunity for an intervention.

Purpose: The purpose of this Doctor of Nursing Practice (DNP) quality improvement project

was to increase timely compliance with the use of smoke evacuation systems during all smoke-

producing procedures, ensuring alignment with safety standards and legislative requirements.

Methods: A systematic evidence review of academic …

Uncertain Enforcement And Standing To Sue, Ernest A. Young

Faculty Scholarship

Plaintiffs with strong claims that a law is unconstitutional may yet fail to establish standing when the law is rarely enforced. Other statutes, like Texas’s unusual abortion law, may render challenges difficult by delegating enforcement to private parties who are difficult to identify in advance. Both problems arise from the assumption that the law shapes behavior only through sanctions imposed in enforcement proceedings. This view is mistaken, both jurisprudentially and empirically. Worse, it requires courts to ask two unanswerable questions: How likely is enforcement? And how likely does Article III require it to be? It also asks standing doctrine to …

Should Judicial Opinions Be Read Like Statutes?, Margaret H. Lemos

Faculty Scholarship

Should judicial opinions be interpreted with an eye to their purpose, context, or the intent of their authors, or should interpreters focus on the ordinary meaning of the text? Opinions present the same sorts of interpretive puzzles as other legal texts, and yet they have been omitted from the debates over interpretive methodology that dominate the fields of constitutional and statutory interpretation. The omission is no accident: the Supreme Court has stated repeatedly—and with increasing frequency in recent years—that judicial opinions are not to be read like statutes. Yet neither courts nor commentators have explained why the principles that ground …