Digital Commons Network^™

Vape Counseling At Pediatric Practices: The Rethink Vape Toolkit, Paul T. Harrell, Ann L. Edwards, Natasha K. Sriraman, Rebecca J. Slimak, Anisha S. Vanka, Amy C. Paulson, Kelli J. England

Department of Pediatrics Faculty Publications

Introduction:

E-cigarettes (Vapes) represent the most common form of tobacco used by adolescents, with one out of every 29 (3.5%) middle school students and one in every 13 (7.8%) of high school students vaping daily. This project aimed to increase vape screening and prevention education in youth visits at pediatric practices, to increase provider comfort with the topic of vaping, and to evaluate this educational process.

Methods:

A provider training and resource modules (talking points, billing codes, and shareable parent/teen-tailored resources) were developed. Providers (N = 32) completed an anonymous pre/postsurvey regarding their knowledge, comfort levels, barriers, and practices related …

Confessions In Cases Of Child Physical Abuse - A Capnet Study, Margaret R. Russell, Antoinette L. Laskey, Henry T. Puls, Suzanne P. Starling, Joanne N. Wood, Daniel M. Lindberg, Nancy S. Harper, Caitlin R. Mcnamara, Angela N. Bachim, Farah W. Brink, Lori D. Frasier, James D. Anderst, Porcia Vaughn, Kristine A. Campbell

Department of Pediatrics Faculty Publications

Objective

Prior research on confessions of physical abuse (PA) has explored mechanisms of injury. Little is known about conditions supporting a confession of abuse or how confessions may influence case outcomes.

Methods

This cross-sectional study of suspected PA in children age < 10 years at 10 centers participating in CAPNET, a multicenter child PA research network, included children with in-person Child Abuse Pediatrics (CAP) consultations between Feb 2021-Dec 2022 and excluded children without injury. Our focus was a confession of inflicted injury known to the CAP during clinical involvement. We compared child and clinical characteristics, out-of-home (OOH) placements, and arrests between cases with and without confessions. Multivariable models using generalized estimating equations (GEE) produced adjusted predicted probabilities (APP) clustering by CAPNET site.

Results

Confessions were known to CAPs in 115/4297 (2.7%) cases, with significant site variability. In a multivariable GEE model, confessions were more likely in cases with injuries with high-specificity for abuse (APP 6.0% vs 1.5%, p< 0.001), near-fatality (APP 5.5% vs 2.3%, p< 0.001), and older children (APP 4.8% vs 2.5%, p = 0.025). OOH placements and arrests were more common in cases with confessions. CAP awareness of confessions, OOH placements, and arrests did not follow racial or ethnic patterns seen in the US child welfare system. Lower socioeconomic status was associated with OOH placements and arrests but not CAP awareness of confessions.

Conclusions

Our findings highlight differences in case characteristics and outcomes where a confession is known to the CAP and raise questions about agency …

Bortezomib And Vorinostat In Combination With Mitoxantrone, Dexamethasone, And Pegasparaginase During Induction And Reinduction For Infants With Acute Lymphoblastic Leukaemia: A Multicentre Single-Arm Phase 1/2 Study, Tanja A. Gruber, Sima Jeha, Rebecca J. Deyell, Victor Lewis, Bill H. Chang, Eric J. Lowe, Jamie Frediani, Catherine Vezina, Bruno Michon, Michael Richards, Erin H. Breese, Thai-Hoa Tran, Norman Lacayo, Christine Bolen, Sunil Desai, Jennifer L. Pauley, Minxuan Huang, Emily Ashcraft, Cheng Cheng, Kirk R. Schultz, Linda Stork, Krysta Schlis, Van T. Huynh, Nathan Gossai, Yoav H. Messinger, Henrique Bittencourt, Terzah M. Horton, Uma Athale, Duncan Stearns, Deborah Schiff, Paul S. Gaynon

Department of Pediatrics Faculty Publications

Background: Acute lymphoblastic leukaemia in infants remains a therapeutic challenge. In preclinical studies we previously identified bortezomib and vorinostat as active agents against KMT2A rearranged (KMT2Ar) leukaemia. The aim of this study was to determine the tolerability of incorporating bortezomib and vorinostat into an acute lymphoblastic leukaemia-chemotherapy backbone for newly diagnosed infants with acute lymphoblastic leukaemia both with and without KMT2Ar.

Methods: In this single-arm phase 1/2 study conducted at 18 hospitals in the USA and Canada, we enrolled patients aged 1 year or younger at the time of diagnosis with newly diagnosed acute lymphoblastic leukaemia or undifferentiated leukaemia (with …

Incorporating New Guidelines Into School-Based Asthma Management, Jessica Michala Jindra, Angela Duff Hogan

Department of Pediatrics Faculty Publications

Purpose of the Review

The aim of this review is to identify barriers and provide solutions to the implementation of inhaled corticosteroid-formoterol as rescue therapy within schools.

Recent findings

GINA guidelines in 2019 and NAEPP in 2020 recommended inhaled corticosteroids combined with formoterol for a rescue inhaler over the traditional short-acting beta-agonist.

Summary

The findings discussed in this article describe the barriers to the implementation of inhaled corticosteroids combined with formoterol for a rescue inhaler in school systems. Traditional asthma action plans, school nursing and parental education, and differences in dosing are some barriers identified. This paper provides solutions for …

35 Individuals With Huwe1-Related Neurodevelopmental Disorder And Suggested Clinical Evaluations, Mindy H. Li, Deziree L. Coleman, Kelsey Hogan, Danielle Luz, Lindsay Bhandari, Newell Belnap, Tiffany Busa, Charles Coutton, Klaus Dieterich, Svetlana Gorokhova, Clara Hildebrandt, Rachel Logan, Milena Mariani, Manuela Morleo, Vincenzo Nigro, John Pappas, Rachel Rabin, Kelly Schoch, Angelo Selicorni, Vandana Shashi, Rebecca Spillman, Jennifer Sullivan, Charlotte Tardy, Samantha A. Schrier Vergano, Brock Grill, Kristin Baranano

Department of Pediatrics Faculty Publications

HUWE1 (HECT, UBA, and WWE Domain Containing E3 Ubiquitin Protein Ligase1, OMIM 300697), located at Xp11.22, encodes a ubiquitin ligase that is highly conserved across species. Genetic variants in HUWE1 described in multiple independent studies cause X-linked intellectual disability, including in the patients identified by Juberg, Marsidi, and Brooks. This report describes 35 additional cases of individuals with variants in HUWE1 and suggested guidelines for clinical management. Our study includes several female cases, which have not been widely reported previously. Our findings confirm earlier reported clinical features including developmental delay, autism, hypotonia, short stature, and dysmorphic facial features as well …

Grant-O-Thon: A Designathon-Informed Grant Writing Program To Enhance Research Grant Writing Skills In Low- And Middle-Income Countries, Yusha Tao, Gifty Marley, Lauren Fidelak, Bin Yu, Yusuf Babatunde, Anita N. Walker, Anthony A. Attama, Andrea L. Conroy, Esther K. Afolabi, Dimitrios N. Vatakis, Iheanyi Omezuruike Okonko, Shyngle K. Balogun, Hongyun Fu, Xin Peng, Ijeoma M. Ifeorah, Patience Kukundakwe, Alexandra Cossio, Ifeoma M. Obionu, Ángela Patricia Beltrán López, Matthew Idowu Olatubi, Ucheoma C. Nwaozuru, Yuanyi Chen, Huachun Zou, Eneyi E. Kpokiri, Daniil Wu, Oliver Ezechi, Juliet Iwelunmor, Meredith Labarda, Jason J. Ong, Weiming Tang, Joseph D. Tucker

Department of Pediatrics Faculty Publications

Problem

Early career researchers in low- and middle-income countries (LMICs) face substantial barriers when writing research grants and have limited writing support. A designathon approach was applied to organize a grant writing workshop (grant-o-thon) tailored for early-career LMIC researchers. This study describes the planning, implementation, and participant-reported outcomes of the grant-o-thon as a participatory training approach.

Approach

Grant-o-thons were organized in 2023, 2024, and 2025. Consistent with the designathon model, the grant-o-thon was structured in three stages: preparation using co-creation with end-users, intensive collaborative teamwork supported by mentor feedback and weekly writing deliverables, and structured follow-up. Each grant-o-thon consisted of …

Gender Differences In The Association Between Adverse Childhood Experiences And Drug Use: Findings From A Community-Based Survey In China, Hongyun Fu, Elizabeth Monk-Turner, Xiushi Yang

Department of Pediatrics Faculty Publications

Background

While adverse childhood experiences (ACEs) are widely recognized risk factors for behavioral health problems, including drug use, prior research has largely been conducted in Western countries, focused primarily on males, and relied on convenience samples without comparison groups of nonusers. Limited work has examined the impact of ACEs on drug use in non-Western contexts. This study examines gender differences in the relationship between ACEs and drug use in China, using data from a population-based probability sample survey.

Methods:

Cross-sectional data were collected in 2019 from one city in Yunnan Province in Southwest China and one city in Guangdong Province …

Empowering Caregivers, Protecting Patients: An Ambulatory Central Line Quality Improvement Initiative For Education And Follow-Up, Elizabeth Martinez, Belinda Bordeaux, Stephanie Langevin, Cristina Herrera, Mary Smith, Merissa Doyle, Barbara Stein, Kimberly Poshar, Marissa Dunlap, Allison Silva, Eric Werner

Department of Pediatrics Faculty Publications

Introduction: Preventing ambulatory central line-associated bloodstream infections (A-CLABSIs) is challenging due to inconsistent education, follow-up, and home care practices. Pediatric intestinal failure (IF) patients are particularly vulnerable. This institution aimed to decrease its IF A-CLABSI rate by 25% within 2 years through a standardized, step-by-step central line care education program.

Methods: Using the Toyota problem-solving method, the team reviewed data and performed a root cause analysis of the prioritized problem, implementing a 2-phase education program. Phase 1 delivered in-hospital education using videos, handouts, and hands-on teaching with skill demonstration. The existing pediatric central line skills class was expanded and offered …

Type 2-Low Asthma: Epidemiology, Multiomics, And Emerging Therapies, Philip Mendez, Alanis Rosado, Juan Carlos Cardet

Department of Pediatrics Faculty Publications

Purpose of Review

Type 2-low (T2-low) asthma, characterized by low blood and sputum eosinophils and low fractional exhaled nitric oxide (FeNO), remains a major unmet need because of frequent corticosteroid insensitivity and a lack of targeted therapies. This review summarizes recent advances in its epidemiology, multiomics, and therapeutic landscape.

Recent findings

T2-low inflammation is highly prevalent, affecting approximately 14%-39% of adults with current asthma and up to 60% of children. Its pathogenesis reflects complex non-T2 mechanisms, including IL-17 signaling, innate immune activation through IL-1β and IL-33, and neutrophilic inflammation. Heterogeneity is further shaped by systemic factors such as obesity and …

Planning A Clinical Practice Guideline Revision For A Core Set Of Outcome Measures In Adults Undergoing Neurologic Physical Therapy, Part 1: Assessing Dissemination And Scholarly Uptake, Jennifer Moore, Jane E. Sullivan, Marghuretta D. Bland, Wendy Romney, Elizabeth Anderl, Zeynep Gulen Erkoc, Kristen Potter

Physical Therapy Faculty Publications

Introduction

Clinical Practice Guidelines (CPGs) facilitate evidence-based decision-making and standardising care, yet their dissemination and scholarly uptake vary widely. The Core Set of Outcome Measures for Adults With Neurologic Conditions Undergoing Rehabilitation CPG (Core Set) has been broadly referenced within neurologic physical therapy. As the next revision approaches, understanding its scholarly influence, citation patterns, and published feedback is essential. This study evaluated the dissemination and use of the Core Set across the peer-reviewed literature and identified areas for refinement.

Methods

A medical librarian conducted comprehensive searches of Web of Science, CINAHL, and Scopus to identify peer-reviewed English-language articles citing the …

Planning A Clinical Practice Guideline Revision For A Core Set Of Outcome Measures In Adults Undergoing Neurologic Physical Therapy, Part 2: Determining Stakeholders' Uptake And Recommendations, Jane E. Sullivan, Kristen Potter, Marghuretta D. Bland, Elizabeth Anderl, Wendy Romney, Zeynep Gulen Erkoc, Jennifer Moore

Physical Therapy Faculty Publications

Objective: To determine the uptake and recommendations for revision of the 2018 Clinical Practice Guideline (CPG): Core Set Outcome Measures for Adults with Neurologic Conditions Undergoing Rehabilitation.

Design: Online Survey

Setting: Online with participants from multiple settings.

Participants: Licensed physical therapists (PT) or physical therapist assistants (PTA) or a non-PT supervisor of PTs and/or PTAs.

Interventions: N/A.

Main Outcome Measures:  An online survey was developed to determine respondents' knowledge, perceived benefits, challenges, gaps, and modifications made to the 2018 CPG as well as to ascertain respondents' recommendations for the CPG revision. Data were analyzed descriptively by respondent role (clinician, educator/researcher, …

Readability Of Online Patient Education Materials For Myopia Management, Monica Jong, Michelle Waugh, Pinar Ozmizrak, Ian Flitcroft

Research Outputs: 2025-Present

Purpose: Patients are turning to the internet to access educational materials to help them make healthcare decisions, making readability an important factor. This cross-sectional study assessed the readability of online patient education materials for myopia management treatments that have regulatory approval. Methods: The top 10 Google search results from May 2024 for freely available online patient information on myopia management modalities and regulatory-approved products in Canada and Australia were analysed for readability. The modalities included orthokeratology, myopia control spectacle lenses, myopia control soft contact lenses and atropine. The products included MiYOSMART® [HOYA®], Stellest® [Essilor®], MyoCare® [ZEISS], MiSight® 1 day [CooperVision®], …

Smart Biosensing Nanomaterials For Alzheimer’S Disease: Advances In Design And Drug Delivery Strategies To Overcome The Blood–Brain Barrier, Manickam Rajkumar, Furong Tian, Bilal Javed, Bhupendra G. Prajapati, Paramasivam Deepak, Koyeli Girigoswami, Natchimuthu Karmegam

Research Outputs: 2025-Present

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder marked by persistent memory impairment and complex molecular and cellular pathological changes in the brain. Current treatments, including acetylcholinesterase inhibitors and memantine, only help with symptoms for a short time and do not stop the disease from getting worse. This is mainly because these drugs do not reach the brain well and are quickly removed from the body. The blood–brain barrier (BBB) restricts the entry of most drugs into the central nervous system; therefore, new methods of drug delivery are needed. Nanotechnology-based drug delivery systems (NTDDS) are widely studied as a potential …

Identification Of Microbial Hotspots And Biofilm-Forming Bacteria In A High Output Industrial Cheese Plant: Comparative Evaluation Of Enzymatic Versus Sodium Hydroxide-Based Cleaning-In-Place (Cip) For Biofilm Removal, Karan J. Pant, Martin G. Wilkinson, Murali Kumar, Hend Roshdy, Sai Ravi Chandra Nori, Vincenzo Fiore, Antonio Lourenco, Jamie A. Fitzgerald, Wiley Barton, Paul D. Cotter, Jeremiah J. Sheehan

Research Outputs: 2025-Present

Effective cleaning and sanitation are essential in cheese manufacturing to control microbial contamination and prevent biofilm formation. A multi-step approach was undertaken to assess microbial persistence and cleaning-in-place (CIP) strategies at an industrial Cheddar cheese facility with a production capacity of ∼40,000 tonnes. Pre- and post-CIP environmental swabs were analysed using plate counts and high-throughput (16S rRNA amplicon and shotgun) sequencing to identify microbial hotspots. Traditional CIP was broadly effective, however residual contamination persisted in critical zones such as the Alfomatic weir, curd distribution tank (CDT), and block formers. Industrial-scale trials comparing caustic and acid-based CIP with an enzymatic alternative …

Red-Sensitive Photopolymerizable Glass For Fabrication Of Holographic Optical Elements, Jamshed Aftab, Izabela Naydenova, Tatsiana Mikulchyk

Research Outputs: 2025-Present

Water-resistant photopolymerizable glass, which represents a photopolymerizable hybrid sol–gel (PHSG) material, has emerged as a compelling platform for holographic optical elements fabrication (HOEs), owing to its exceptional mechanical and thermal robustness with high holographic recording performance. Until now, PHSG compositions have been limited to blue/green-sensitive systems, despite significant interest in extending sensitivity into the red spectral region. Here, we report the first holographic photopolymerizable glass with sensitivity to red light, achieved through the incorporation of methylene blue (MB) as a photosensitizer and N-phenylglycine (NPG) as a co-initiator, with an optimal MB/NPG ratio of 1:150. This PHSG composition is capable of …

Ocular Dominance Is Associated With Interocular Asymmetry In Refractive Error And Axial Length Across Childhood And Early Adulthood, Síofra C. Harrington, Gareth Lingham, James Loughman, Ian Flitcroft, David A. Mackey, Michael Moore

Research Outputs: 2025-Present

Purpose: To determine whether ocular dominance is associated with systematic interocular asymmetry in spherical equivalent refraction (SER) and axial length (AL) across childhood and early adulthood, and assess whether such asymmetry exceeds laterality effects. Methods: Data were analysed from three population-based cohorts: 728 children (6–7-year-olds) and 898 adolescents (12–13-year-olds) from Ireland and 303 young adults (25–30-year-olds) from Western Australia. Ocular dominance was assessed using sighting tests. SER was measured by cycloplegic autorefraction and AL by optical biometry. Interocular differences were evaluated using paired comparisons, concordance correlation coefficients (CCC), Deming regression, Bland–Altman analyses and mediation modelling. Analyses were stratified by refractive …

A Comparative Analysis Of The Efficacy, Safety And Mechanism Of Action Of Flebogamma Dif, Fostamatinib And Romiplostim In Immune Thrombocytopenia, Mary Akinyemi, Kamna Ravi, Furong Tian, Baljit Singh

Research Outputs: 2025-Present

Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by immune-mediated platelet destruction, resulting in a platelet count below 100 × 10⁹/L and an increased risk of bleeding complications that significantly impair quality of life. Despite advances in ITP management, the unpredictable and heterogeneous nature of the disease continues to challenge treatment selection. This review compares the efficacy, safety, and mechanisms of action of Fostamatinib, Flebogamma DIF, and Romiplostim in adult and pediatric ITP patients. Peer-reviewed studies published over the past 20 years, including randomized and non-randomized clinical trials, observational studies, and real-world evidence, were screened for relevance, with …

Sustainable Remediation Of Antibiotic Contaminants Using Engineered Biochar And Composite Materials, Arvind Kumar, Prerna Sunar, Duraisamy Ramamoorthy, Swapnamoy Dutta, Ravikant Verma, Km Smriti Jaiswal, Krishna Kumar Jaiswal, Vinod Kumar, Amit K. Jaiswal, Mahaveer D. Kurkuri

Research Outputs: 2025-Present

Antibiotic contamination is a growing global crisis due to widespread use and unregulated disposal, contributing to the proliferation of antibiotic-resistant microbes and ecological risks. This review critically evaluates antibiotic contamination and its impact on the environment and human health. Biochar and modified biochar modulate antibiotic resistance gene (ARG) dynamics and the destruction of ARG transfer. Optimization of biochar properties includes surface chemistry, structure, synthesis process, and surface engineering to enhance antibiotic adsorption and degradation. Therefore, a comprehensive evaluation of biochar and modified biochar for the adsorption and degradation of different antibiotics under diverse water and soil chemistry conditions is needed. …

Human-Centered Evaluation Of Control And Perception Interface Factors In A Teleoperational Cutting Task, Inês F. Ramos, Keerthi Sagar, Philip Long, Maria Chiara Leva, Ernesto Damiani, Gabriele Gianini

Research Outputs: 2025-Present

Despite significant advances in teleoperated systems, optimal human performance remains a challenging task due to one key aspect, i.e. reduced situational awareness. Active telepresence is one of the major contributing factors affecting operator’s situational awareness. Providing the user with multiple perspectives of the remote environment can be very beneficial, although it may also introduce challenges in maintaining effective control. Prior work has largely examined discrete manipulation tasks using single-modality assessments, whereas this study applies a multimodal neuroergonomic approach to a continuous precision-cutting task, providing first insights into control–view alignment and multi-camera perception effects. In this work, we focus on two …

Valorisation Of Barley Straw For Sustainable Nanocellulose Production Via Subcritical Alkaline Hydrolysis And Hdes-Assisted Processing, Dileswar Pradhan, Swarna Jaiswal, Brijesh K. Tiwari, Amit K. Jaiswal

Research Outputs: 2025-Present

This study investigates a sustainable and efficient approach to valorising barley straw by producing nanocellulose via an integrated subcritical alkaline hydrolysis and HDES-assisted processing pathway. Subcritical alkaline pretreatment under best processing conditions (150 bar, 200 °C, 125 min) enabled effective biomass fractionation, achieving average hemicellulose and lignin solubilisation of 57.72% and 82.69%, respectively. Subsequent purification of the pretreated solid fraction yielded cellulose fibres with an average cellulose yield of 41.97% and a purity of 87.87%. Nanocellulose was then obtained using a sequential HDES treatment followed by high-intensity ultrasound (HIUS), producing a sample (NC-BTW-3) in which 66% of particles exhibited diameters …

Multifunctional Nanomaterials Coupled With Ai-Based Optimization For Advanced Wastewater Treatment, Ananya Tiwari, Isha Dharsandia, Shreedhar Tiwari, Gajendra Singh Vishwakarma, Budhi Sagar Tiwari, Narendra Kumar, Amit K. Jaiswal

Research Outputs: 2025-Present

Conventional wastewater treatment performs reliably against routine contaminants but remains inconsistent for complex industrial effluents and for emerging pollutants such as pharmaceutical residues, per- and polyfluoroalkyl substances and micro/nano plastics. Engineered nanomaterials and artificial intelligence (AI)/machine learning (ML) have each been reviewed extensively, but predominantly in isolation. The present review is distinguished from existing reviews in three specific respects. First, the nanomaterial-AI interface is treated as the unit of analysis rather than the two fields being surveyed in parallel: AI-guided material selection, dosing and pH control, membrane fouling prediction, nano sensor-assisted monitoring and regeneration scheduling are examined together. Second, evidence …

Thermophilic Microorganisms For Bioremediation Of Industrial Pollutants Including Hydrocarbons And Heavy Metals, Isha Dharsandia, Narendra Kumar, Ananya Tiwari, Amit K. Jaiswal

Research Outputs: 2025-Present

Industrialization and urbanization have led to the constant discharge of hazardous pollutants such as effluents, hydrocarbons, and heavy metals, which pose a grave threat to ecological balance and human beings' well-being. Traditional physiochemical techniques for the treatment of environmental pollutants are energy-intensive, expensive, and inefficient in extreme environments. Hence, there is a need to explore alternative strategies to address the above problems. Thermophiles are microorganisms that grow in high temperatures, and they have recently been regarded as viable sources for bioremediation due to their metabolic resilience, enzyme stability, and resistance to industrial conditions. The current paper presents an in-depth literature …

Investigation Of Different Aeration Strategies For The Production Of Kombucha With Defined Co-Cultures, Marie Ludszuweit, Leon Bender, Gayatri Mehta, Martin Hageböck, Brian Gibson, Martin Senz

Research Outputs: 2025-Present

Kombucha fermentation is a complex process influenced by many different process parameters and the dynamics of the microorganisms present. Since no universally established standards exist for large-scale production of kombucha, manufacturers still need to acquire the knowledge to establish controllable and reproducible processes. The aim of this study was to investigate the extent to which the kombucha fermentation process can be influenced by varying the oxygenation regime and the initial pH value. For this purpose, co-culture fermentations with the yeast Zygosaccharomyces bailii and the acetic acid bacterium Komagataeibacter hansenii were carried out under defined conditions, varying the type and intensity …

Transient Nanomaterials And Stimuli-Driven Transformation Pathways For Clean Energy Applications And Environmental Remediation, Mrinal, Navya Vikraman Nair, Lovepreet Singh, Harshita Jain, Krishna Kumar Jaiswal, Amit K. Jaiswal

Research Outputs: 2025-Present

The growing use of nanomaterials in clean energy and remediation has led to unintended consequences, including long-term persistence, secondary contamination, and accumulation in the natural environment. Traditional materials design has focused on stability and durability, but those qualities could be liabilities if materials outlive their intended purpose. This study suggests using transient nanomaterials as a design paradigm, in which materials are engineered to perform optimally for a specific period of time and then undergo controlled transformation, deactivation, or disappearance. The review focuses on the conceptualization of transient nanomaterials and how they may be distinguished from degradable, recyclable, and stimuli-responsive materials. …

Biogenic Chitosan-Encapsulated Cu/Zno Nanocomposite Surface Coating Inhibits Mdr Pseudomonas Aeruginosa Biofilm Establishment On Orthopedic Implants, Bushra Uzair, Zukhra Abbasi, Fehmida Fasim, Shoaib Alam, Apori Samuel Obeng, Furong Tian

Research Outputs: 2025-Present

Orthopedic implant-associated infections (IAIs), predominantly caused by Pseudomonas aeruginosa, represent a major clinical challenge due to antibiotic resistance and biofilm formation, which together contribute to their chronic nature. This research presents a biogenic biofilm-resistant chitosan encapsulated Cu/ZnO nanocoating (CS-Cu/ZnO NC) synthesized using Euphorbia thymofolia metabolites and applied on orthopedic implant surface (Tubular bone locked stainless steel plates). The synthesized CS-Cu/ZnO NCs were characterized physicochemically (UV–Vis, FTIR, XRD, SEM) and biologically (antibacterial, antibiofilm, antivirulence, hemolysis and cytotoxicity). Microstructural analysis using UV–Visible Spectroscopy (UV–Vis), X-ray diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR) and Scanning Electron Microscopy (SEM) confirmed the successful synthesis, crystallinity …

Finger Millet Extract Powder As A Sustainable Route To Enhanced Fermentation And Functional Quality In Cereal Food, Lavanya Manivannan, Ravikumar Rajarathinam, Raju Sasikumar, Amit K. Jaiswal

Research Outputs: 2025-Present

Finger millet (Eleusine coracana), a climate-resilient cereal, offers a sustainable substrate for fermented foods. This study investigates the use of finger millet extract (FME) powder as a value-addition strategy in batter fermentation. Finger millet–black gram and FME powder with black gram blends were naturally fermented separately for 12 hours at a ratio of 3 : 1. In order to comprehend the impact of FME incorporation on fermentation performance and product quality, the study compared the physicochemical, biochemical, microbiological, and rheological characteristics of fermented finger millet (FM) batter with those of FME batter. FME incorporation hastened fermentation, reflected by steeper drops …

Accuracy Of Voluntary Force Modulation During The Isometric Mid-Thigh Pull, S. Alexander Long, Olivia Vadas, Stephanie Balint, Michael H. Stone, Christopher Taber

Exercise Science Faculty Publications

The purpose of this study was to investigate voluntary force modulation accuracy during the isometric mid-thigh pull (IMTP) and to investigate biological sex and relative strength as factors relating to error. Strength-trained males (n = 18) and females (n = 18) completed ascending (ASC) (25%, 50%, 75%) or descending (DESC) (75%, 50%, 25%) submaximal testing followed by maximal testing. Subjects rested before completing the opposite submaximal testing sequence. External feedback was not provided during testing. Measured and intended (INT) forces were analyzed with two-way repeated-measures ANOVAs with within- (ASC, DESC, and INT) and between-subject factors (male or female). Independent-samples t-tests …

Harmonic Mitigation And Reactive Power Support Using Dpfc And Upfc In Grid‑Connected Solar Pv Systems: A Comparative Performance Evaluation, Abhishek Vashistha, Dharmbir Prasad, Rudra Pratap Singh

Mansoura Engineering Journal

Harmonic distortion, reactive power imbalance, and voltage instability represent major challenges regarding the power quality of grid-connected solar photovoltaic (PV) systems. Various recently developed flexible AC transmission system (FACTS) devices such as the unified power flow controller (UPFC) and distributed power flow controller (DPFC), however, have made them possible solutions but still do not provide a quantitative comparison in similar dynamic conditions. In this paper, comparative performance analysis of UPFC and DPFC in 3 MW grid connected solar PV system using Matlab Simulink is presented. The two controllers are affected by same disturbances, namely irradiance step change at t = …

A Dual-Domain Face Forgery And Deepfake Detection Framework, Neha Pradyumna Bora, Pradyumna Mulchand Bora, Rushikesh Sanjay Kumavat, Raunak Manoj Gangwal, Prit Sandesh Jain, Hardik Vijay Ostwal

Mansoura Engineering Journal

Concerns about media authenticity, privacy, and information security arising from rapid advances in deepfake technology have made it increasingly important to detect manipulated facial content reliably. The primary goal of our work was to develop a deepfake detection model with high generalization across multiple datasets. To achieve this, we developed a hybrid detection approach that combines spatial visual texture analysis and frequency-domain analysis to detect manipulated facial images. Our approach includes convolutional spatial feature extraction from facial images and frequency—domain representations of the same images obtained by applying the fast Fourier transform. To help alleviate concerns about overreliance on frequency—domain …

Multi-Method Energy Optimization: Linear Programming, Hmm Modeling And Arduino-Based Simulations, A.E. El-Alfy, Eman Elayat, M. A. E. Sheta

Mansoura Engineering Journal

This paper presents the simulation and optimization of hybrid energy systems integrating renewable energy and storage technologies. Linear Programming (LP) is utilized to minimize operational costs, while a Hidden Markov Model (HMM) improves reliability by accurately predicting energy flow. Hardware-in-the-loop simulation in Proteus demonstrates efficient energy trading, significantly reducing dependence on conventional sources. The results from a 24-hour analysis show that the system achieves an 87.14% load factor, indicating high efficiency in utilizing the system's rated capacity, 26.23 system reliability, and a 20% improvement in cost efficiency and enhanced sustainability, providing a robust and practical framework for hybrid energy solutions …