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Empowering Caregivers: An Occupational Therapy-Informed Educational Program For Dementia Care In Rural Communities, Maria Lynn Johnson Jan 2026

Empowering Caregivers: An Occupational Therapy-Informed Educational Program For Dementia Care In Rural Communities, Maria Lynn Johnson

Occupational Therapy Capstones

Purpose: Hospitalization presents significant risks for individuals with dementia, including increased behavioral and psychological symptoms (BPSD), delirium, functional decline, and reduced occupational engagement (Boltz et al., 2023; Teichmann et al., 2019; Zwingmann et al., 2020). Acute care environments are often overstimulating, unfamiliar, and task-oriented, which can exacerbate cognitive impairment and contribute to caregiver distress. Despite strong evidence supporting nonpharmacological, occupation-based interventions, structured engagement opportunities are rarely integrated into acute care workflows (Burgdorf et al., 2023; Faeder et al., 2023). This doctoral capstone project aimed to develop occupation-based dementia activities for use during hospitalization while equipping formal and informal caregivers with …


Quality Of Life Of Individuals Residing In Senior Living Facilities, Meagan R. Danda Jan 2026

Quality Of Life Of Individuals Residing In Senior Living Facilities, Meagan R. Danda

Occupational Therapy Capstones

Introduction: Formal caregivers play an essential role in supporting residents’ physical, emotional, and social needs which contribute to overall health and well-being (Spilsbury et al., 2024). Due to these responsibilities, caregivers need to be properly equipped with the knowledge and skills necessary to perform clinical duties with confidence. The purpose of this scholarly project is to develop a product that increases caregiver confidence by providing caregivers with occupational therapy informed education. By enhancing caregivers’ knowledge and skill set, this product may contribute to a supportive environment that fosters resident engagement in meaningful occupations and promotes improved quality of life (QoL) …


Determining Driving Ability Following Traumatic Brain Injury, Shauna M. Corrigan Jan 2026

Determining Driving Ability Following Traumatic Brain Injury, Shauna M. Corrigan

Occupational Therapy Capstones

Introduction: A traumatic brain injury (TBI) can be a severe injury that causes lasting effects such as visual changes, challenges with concentration and memory, and problems with coordination and balance (Centers for Disease Control, 2024). This can impact an individual’s ability to safely return to the valued occupation of driving. Occupational therapists will commonly assess an individual’s ability to return to drive following a TBI, but they experience challenges in doing so due to a lack of standard method in assessing one’s safety while operating a motor vehicle (Baker et al., 2015; Tamietto et al., 2006; Classen et al., 2009; …


Demonstration Of Infrared Pavement Heater, Dwayne Harris Jan 2026

Demonstration Of Infrared Pavement Heater, Dwayne Harris

JTRP Technical Reports

Indiana Department of Transportation (INDOT) maintenance currently employs several patching methodologies; however, prior to this study, INDOT had little experience with using infrared pavement heaters as a maintenance tool.  The purpose of this research was to introduce pavement heating technologies and provide INDOT maintenance personnel with experience using these technologies.


Simulating Current And Future Ev Growth Scenarios In Indiana, Omar Faruqe Hamim, Xiaowei Chen, Kenny Chandra Wijaya, Lavan Teja Burra, Zengxiang Lei, Rajat Verma, Konstantina (Nadia) Gkritza, Satish Ukkusuri Jan 2026

Simulating Current And Future Ev Growth Scenarios In Indiana, Omar Faruqe Hamim, Xiaowei Chen, Kenny Chandra Wijaya, Lavan Teja Burra, Zengxiang Lei, Rajat Verma, Konstantina (Nadia) Gkritza, Satish Ukkusuri

JTRP Technical Reports

As Indiana transitions toward electric mobility, data-driven planning is essential to guide electric vehicle (EV) charging infrastructure investment and deployment. This study evaluates the current and future performance of Indiana’s EV charging infrastructure using Multimodal Energy-Efficient Trip Simulation in Real Time (METS-R), a high-resolution simulation platform. Five EV adoption scenarios, ranging from pessimistic to optimistic, are modeled for the years 2024 through 2031, to assess spatial and temporal variations in public charging demand. Results reveal increasing public charging demand under high adoption scenarios, with significant disparities between urban and non-urban areas. Accessibility to public charging is found to be uneven …


Sport Training Day Affects Adolescent Athletes’ Sleep Schedules, Abigail Larson, Jena Heck Street, Roman De Guia, Jacob J. Capin Jan 2026

Sport Training Day Affects Adolescent Athletes’ Sleep Schedules, Abigail Larson, Jena Heck Street, Roman De Guia, Jacob J. Capin

Physical Therapy Faculty Research and Publications

Introduction: Sufficient sleep is integral to overall health whereas suboptimal sleep puts athletes at greater risk for injury, lengthens their recovery time, and decreases their performance. Our purpose was to compare sleep across training days (i.e., competition, practice, and rest) in adolescent athletes, specifically identifying differences between nights before and after training.

Methods: Participants [n = 33 (14 male, 19 female), aged 15.6 ± 1.0 years] wore an activPAL accelerometer continuously for 14 consecutive days and completed a sleep log noting training day status (i.e., competition, practice, rest).

Results: Athletes slept less on the day after competition compared to …


Social Safety And Social Security: Validating Context-Specific Instruments For Slums, Liss D. Romero, Katherine Palacio, Zacheous Ako Abang, Valeria Silgado, Humberto Llinas, Leidy González, Erika Frydenlund, Daniel Bolivar, Jose J. Padilla Jan 2026

Social Safety And Social Security: Validating Context-Specific Instruments For Slums, Liss D. Romero, Katherine Palacio, Zacheous Ako Abang, Valeria Silgado, Humberto Llinas, Leidy González, Erika Frydenlund, Daniel Bolivar, Jose J. Padilla

VMASC Publications

Social safety and social security are concepts that help explain a community's well-being by assessing how it manages and mitigate existing, or perceived, risks. However, these terms are often conflated, which can limit understanding, particularly in areas with unstable living conditions. This study explores both concepts in the context of residents living in slums. As the number of displaced people grows, slums and informal settlements are becoming increasingly common worldwide, making it essential to clarify these concepts. Residents of slums face numerous hazards, including crime, violence, inadequate housing, overcrowding, and limited access to essential services. To measure social safety and …


Socio-Spatial Patterns Of Suicide Mortality In The United States, Kushagra Tiwari, M. Amin Rahimian, Marie-Laure Charpignon, Philippe J. Giabbanelli, Praveen Kumar Jan 2026

Socio-Spatial Patterns Of Suicide Mortality In The United States, Kushagra Tiwari, M. Amin Rahimian, Marie-Laure Charpignon, Philippe J. Giabbanelli, Praveen Kumar

VMASC Publications

Suicides cause more than 49,000 deaths per year in the United States, including 55% associated with the use of a firearm. Across states and counties in the US, suicide mortality exhibits substantial geographical and sociodemographic heterogeneity. However, the role of large-scale social networks in shaping this variation remains underexplored. To assess how both the risk of suicide mortality and the effect of firearm restriction policies propagate through inter-county social ties, we integrate data on county-level suicide mortality (2010–2022) and the Facebook Social Connectedness Index (SCI), a continuous measure of the strength of social ties between counties used to derive weighted …


Synergistic Sensitization Of Pancreatic Cancer Cells By Nanosecond Pulsed Electric Fields And Cold Atmospheric Plasma Via Amplifying Ros And Apoptotic Signaling, Zobia Minhas, Edwin A. Oshin, Lifang Yang, Chunqi Jiang, Siqi Guo Jan 2026

Synergistic Sensitization Of Pancreatic Cancer Cells By Nanosecond Pulsed Electric Fields And Cold Atmospheric Plasma Via Amplifying Ros And Apoptotic Signaling, Zobia Minhas, Edwin A. Oshin, Lifang Yang, Chunqi Jiang, Siqi Guo

Bioelectrics Publications

Pancreatic cancer remains a highly lethal malignancy, with standard therapies offering limited benefits in advanced stages; thus, novel strategies that exploit specific cancer cell vulnerabilities are urgently needed. Building on our previous findings that nanosecond pulsed electric fields (nsPEF) combined with cold atmospheric plasma (CAP) produce enhanced cytotoxicity, this study investigates the molecular mechanisms underlying this synergy. Pan02 pancreatic cancer cells were subjected to nsPEF, CAP, or a combination of both. We assessed cell viability, reactive oxygen species (ROS) production, and mitochondrial integrity using metabolic assays, flow cytometry, and fluorescence microscopy. Apoptotic markers were evaluated via Western blotting and caspase …


Targeting Ptp4a3 And Kvx-053 Mitigates Alcohol-Amplified Sars-Cov-2 Spike Protein-Induced Acute Lung Injury, Pavel A. Solopov, Ruben Manuel Luciano Colunga Biancatelli, Elizabeth R. Sharlow, John S. Lazo, John D. Catavas Jan 2026

Targeting Ptp4a3 And Kvx-053 Mitigates Alcohol-Amplified Sars-Cov-2 Spike Protein-Induced Acute Lung Injury, Pavel A. Solopov, Ruben Manuel Luciano Colunga Biancatelli, Elizabeth R. Sharlow, John S. Lazo, John D. Catavas

Bioelectrics Publications

Introduction: Chronic alcohol exposure is associated with increased vulnerability to acute respiratory distress syndrome (ARDS), and emerging evidence suggests that this susceptibility extends to the severe respiratory manifestations of COVID- 19. The SARS-CoV-2 Spike Protein S1 subunit (S1SP) can independently trigger robust inflammatory and vascular injury responses in the lung, and our prior work demonstrated that chronic alcohol consumption markedly intensifies these effects in mice. PTP4A3 phosphatase is a key regulator of inflammation and endothelial barrier function. In this study, we investigated whether the PTP4A3 inhibitor KVX-053 can counteract alcohol-enhanced S1SP-induced lung injury in K18-hACE2 mice.

Methods: Animals were maintained …


Hsp90 Inhibitor, At13387 Mitigates Chronic Lung Injury In Pre-Pubertal Mice: A Therapeutic Axis In Bronchopulmonary Dysplasia, Pavel A. Solopov, Christiana Dimitropoulou, John D. Catravas, Ruben M. L. Colunga Biancatelli Jan 2026

Hsp90 Inhibitor, At13387 Mitigates Chronic Lung Injury In Pre-Pubertal Mice: A Therapeutic Axis In Bronchopulmonary Dysplasia, Pavel A. Solopov, Christiana Dimitropoulou, John D. Catravas, Ruben M. L. Colunga Biancatelli

Bioelectrics Publications

Exposure to hydrochloric acid (HCl) can provoke severe chronic pulmonary injury. Children are particularly vulnerable due to their smaller airways, higher respiratory rate, and stronger inflammatory response; yet no countermeasures exist for HCl-induced chronic lung injury in the pediatric population. We have previously demonstrated the involvement of HSP90 during HCl-induced lung injury in pre-pubertal (p24) mice, who develop stronger persistent inflammation with higher NLRP3 inflammasome activation, but less pulmonary fibrosis compared to adults. Here, we tested the hypothesis that post-treatment with the second-generation HSP90 inhibitor AT13387 (Onalespib), administered subcutaneously beginning 24 h after HCl instillation, would prevent HCl-induced chronic lung …


Foreword, Mckenzie Porter Jan 2026

Foreword, Mckenzie Porter

University of Colorado Law Review

No abstract provided.


"Women’S Language" In Supreme Court Oral Arguments, Carolina Nunez, Lucy Williams, David Wingate, Aerin Christensen, Anna Mae Walker Jan 2026

"Women’S Language" In Supreme Court Oral Arguments, Carolina Nunez, Lucy Williams, David Wingate, Aerin Christensen, Anna Mae Walker

University of Colorado Law Review

No abstract provided.


The Indelible Flaws Of Conviction Integrity Units, Sarah Gottlieb Jan 2026

The Indelible Flaws Of Conviction Integrity Units, Sarah Gottlieb

University of Colorado Law Review

No abstract provided.


Aggregation At The Bottom, Seema Tahir Saifee Jan 2026

Aggregation At The Bottom, Seema Tahir Saifee

University of Colorado Law Review

No abstract provided.


Narrating The Gap: Generational Experience, Organizational Norms, And The Pursuit Of Cohesion, Nicole E. Madden, Jimmy A. Merino-Cruz, Laura G. Miller, Alice R. Smiley Jan 2026

Narrating The Gap: Generational Experience, Organizational Norms, And The Pursuit Of Cohesion, Nicole E. Madden, Jimmy A. Merino-Cruz, Laura G. Miller, Alice R. Smiley

Educational and Organizational Learning and Leadership Dissertations

Contemporary organizations are increasingly multigenerational, yet much of the existing literature frames generational difference through simplified cohort categories that obscure the relational, structural, and interpretive conditions shaping organizational life. This dissertation examines how individuals across generational experiences make sense of their interactions with one another in organizations, particularly focused on tensions between generational identity and organizational norms. Generational Theory, Organizational Sensemaking, and Narrative Identity informed this study, highlighting the socially constructed, contextually mediated, and narratively interpreted nature of generational experiences rather than fixed or universal. A constructivist qualitative design rooted in narrative inquiry drew upon semi-structured narrative interviews with nine …


Understanding Adaptation, Resilience, And Thriving Among Vietnamese Catholic Missionary Sisters In The United States Through The Lens Of Traditions, Transitions, And Leadership, Huyen T. Nguyen Jan 2026

Understanding Adaptation, Resilience, And Thriving Among Vietnamese Catholic Missionary Sisters In The United States Through The Lens Of Traditions, Transitions, And Leadership, Huyen T. Nguyen

Educational and Organizational Learning and Leadership Dissertations

While the presence of international Catholic Sisters serving in the United States has grown (Johnson et al., 2019), the lived experiences of Vietnamese Catholic Missionary Sisters remain largely absent from the scholarly literature. Addressing this gap, this qualitative study examined adaptation, resilience, and thriving among the Sisters serving in the United States by centering their voices through in-depth narratives. Their experiences were interpreted through Social Identity Theory, Servant Leadership, and Transformational Leadership Theory within the context of Vietnamese Catholicism and the charism of the Lovers of the Holy Cross. Data were collected through semi-structured interviews with 10 Sisters ministering in …


Improving Efficiency In Noma Schemes Having Inter-User Interference Using Mechanism Design, Zory Marantz Jan 2026

Improving Efficiency In Noma Schemes Having Inter-User Interference Using Mechanism Design, Zory Marantz

Publications and Research

Modern wireless systems utilize non-orthogonal multiple access to increase their rate capacities; however, the efficiency of the individual utility defined in bits per Joule has yet to be considered. Multiple variations of non-orthogonal multiple access have the interference of the signal-to-interference-plus-noise ratio as a function of the received power from multiple other users due to code implementations that are non-orthogonal or non-ideal cancellation in successive-interference-cancellation methods. Game theoretic concepts are used to improve user bits-per-Joule performance. Previous solutions increment transmit power and are not based on closed form systematic methods. The mechanism design presented here led to a non-cooperative Nash …


Magang Atau Pekerja? Menggugat Status Abu-Abu Tenaga Paruh Waktu Mahasiswa Di Fakultas Hukum Ugm, Patricia Nerissa Krisna Putri, Markus Togar Wijaya Jan 2026

Magang Atau Pekerja? Menggugat Status Abu-Abu Tenaga Paruh Waktu Mahasiswa Di Fakultas Hukum Ugm, Patricia Nerissa Krisna Putri, Markus Togar Wijaya

Jurnal Hukum & Pembangunan

This study highlights the controversy surrounding the change in nomenclature for student workers at Gadjah Mada University, particularly within the Faculty of Law. The status of these workers has shifted from 'part-time' to 'student intern'. This unilateral change has created a legal grey area that could lead to students being subjected to disguised employment practices. Using socio-legal research methods, this article examines the validity of the 'internship' status based on the elements of an employment relationship (work, orders and wages) within the labour law regime, analysing it using the theory of structural injustice. The research findings suggest that reclassifying part-time …


Research Nexus : Volume 33 - 2026, Office Of Research And Graduate Studies Jan 2026

Research Nexus : Volume 33 - 2026, Office Of Research And Graduate Studies

Office of Research and Graduate Studies

  • Researcher Spotlight
  • Research Milestones & News
  • Capacity Building Initiatives
  • Explore New Funding Opportunities


Internationalization Struggles And Student Mobility: Ethnic Exclusion And Racism In Philippine Higher Education, Yasmin Y. Ortiga Jan 2026

Internationalization Struggles And Student Mobility: Ethnic Exclusion And Racism In Philippine Higher Education, Yasmin Y. Ortiga

Research Collection School of Social Sciences

There is an extensive literature on student mobility that seeks to understand the nature of, rationales for and consequences of internationalisation in higher education. This scholarship primarily focusses on students studying in the ‘west’. This paper shows how ‘atypical’ student destinations also illuminate the contradictions of internationalisation, revealing the challenges faced by higher education settings beyond academic centres in the west. Drawing on the case of the Philippines, I discuss how private universities actively recruited international students to maximise profits from student tuition. Yet, these efforts led to a backlash among Filipino educators and students, prompting administrators to institute policies …


Thinkmatter: Panoramic-Aware Instructional Semantics For Monocular Vision-And-Language Navigation, Guangzhao Dai, Shuo Wang, Hao Zhao, Bin Zhu, Qianru Sun, Xiangbo Shu Jan 2026

Thinkmatter: Panoramic-Aware Instructional Semantics For Monocular Vision-And-Language Navigation, Guangzhao Dai, Shuo Wang, Hao Zhao, Bin Zhu, Qianru Sun, Xiangbo Shu

Research Collection School Of Computing and Information Systems

Vision-and-Language Navigation in continuous environments (VLN-CE) requires an embodied robot to navigate the target destination following the natural language instruction. Most existing methods use panoramic RGB-D cameras for 360° observation of environments. However, these methods struggle in real-world applications because of the higher cost of panoramic RGB-D cameras. This paper studies a low-cost and practical VLN-CE setting, e.g., using monocular cameras of limited field of view, which means “Look Less” for visual observations and environment semantics. In this paper, we propose a ThinkMatter framework for monocular VLN-CE, where we motivate monocular robots to “Think More” by 1) generating novel views …


Memoryart: Enhancing Llms Via Multi-Memory Models With Adaptive Resonance Theory For Healthcare Agents, Renke Dai, Hebin Hu, Jiahui Zhang, Yilin Kang, Ah-Hwee Tan Jan 2026

Memoryart: Enhancing Llms Via Multi-Memory Models With Adaptive Resonance Theory For Healthcare Agents, Renke Dai, Hebin Hu, Jiahui Zhang, Yilin Kang, Ah-Hwee Tan

Research Collection School Of Computing and Information Systems

Though promising in healthcare consultation applications, large language models (LLMs) face critical limitations in retaining and utilizing long-term memory across multiturn interactions. In particular, existing memory enhancing paradigms are constrained by limited context windows and embedding-based retrieval, often failing to maintain task relevance and still suffering from memory prototype collapse in multi-turn healthcare consultation. To address these challenges, we propose a cognitively-inspired memory framework named MemoryART, which is grounded in Adaptive Resonance Theory (ART)—a cognitive and learning theory of how humans and animals adapt to dynamic environments. MemoryART employs three memory modules—working memory, episodic memory, and semantic memory to support …


Clique Annealing: Semi-Supervised Community Detection Under Crystallization Kinetics, Ling Cheng, Jiashu Pu, Ruicheng Liang, Qian Shao, Hezhe Qiao, Feida Zhu Jan 2026

Clique Annealing: Semi-Supervised Community Detection Under Crystallization Kinetics, Ling Cheng, Jiashu Pu, Ruicheng Liang, Qian Shao, Hezhe Qiao, Feida Zhu

Research Collection School Of Computing and Information Systems

Semi-supervised community detection seeks to find a specified community type when only few communities are labeled. Existing "select-then-refine" pipelines often start from mis-aligned cores and rely on Reinforcement-Learning or Generative Adversarial Network, increasing computational cost and limiting scalability. We address these issues with a unified energy framework under crystallization kinetics that jointly models energy, structure, and growth. Based on this perspective, we propose CLique ANNealing (CLANN), which first employs Nucleus Proposer to select candidate clique as community core under four physics-inspired criteria. A learning-free Transitive Annealer then iteratively merges neighboring cliques and repositions the nucleus, enabling spontaneous, scalable community growth. …


Arkansas Corn And Grain Sorghum Performance Tests 2025, J. F. Carlin, J. P. Kelley, T. N. Spurlock, T. D. Swanson, R. D. Bond, J. C. Mccoy, C. J. Bulloch Jan 2026

Arkansas Corn And Grain Sorghum Performance Tests 2025, J. F. Carlin, J. P. Kelley, T. N. Spurlock, T. D. Swanson, R. D. Bond, J. C. Mccoy, C. J. Bulloch

Arkansas Agricultural Experiment Station Research Series

Report Statement This Arkansas Agricultural Experiment Station (AAES) publication summarizes variety trial research conducted by the Arkansas Crop Variety Improvement Program. Variety trial information presented here furthers the AAES mission of conducting research that benefits the citizens of Arkansas by expanding agricultural profitability and strengthening local and state economies. This information is not a recommendation or an endorsement of any product by the University of Arkansas System Division of Agriculture or AAES. Recommendations interpreted from this information are made and presented by the Arkansas Cooperative Extension Service.

Corn and grain sorghum performance tests are conducted each year in Arkansas by …


Crimes Of The Powerful And The Looting Of Contemporary Nigeria: An Integrated Theoretical Perspective, Charles Ubah Jan 2026

Crimes Of The Powerful And The Looting Of Contemporary Nigeria: An Integrated Theoretical Perspective, Charles Ubah

African Journal of Criminology and Justice Studies

Crime of the powerful is a humongous social problem with the potential to ravage development and threaten the corporate existence of nation states. The case of contemporary Nigeria is the focal point of analysis in this paper. The objective of the paper, therefore, is to investigate the menace in Nigeria from an integrated theoretical perspective. The methodology was exploratory survey and review of literature which were content analyzed. The theoretical framework is a kind of Modified Multiple Reinforcing Social Forces Theory. Findings indicate that, beside its high prevalence rate, elite criminality in the various forms of corruption, property and environmental …


Prosocial Ceos And Accounting Manipulation, Mei Feng, Weili Ge, Zhejia Ling, Wei Ting Loh Jan 2026

Prosocial Ceos And Accounting Manipulation, Mei Feng, Weili Ge, Zhejia Ling, Wei Ting Loh

Research Collection School Of Accountancy

This paper examines the association between chief executive officers’ (CEOs’) prosocial tendency and their firms’ likelihood of accounting manipulation. We measure CEOs’ prosocial tendency based on their involvement with charitable organizations. We find that prosocial CEOs are less likely to engage in accounting manipulation, as proxied by material non-reliance restatements and SEC or DOJ enforcement actions. The effect is more pronounced when CEOs are involved with charities that directly aim to improve the welfare of others and when they face stronger incentives to misreport. These results continue to hold in analyses of changes in CEOs’ prosocial tendency around turnover events. …


Assessing The Feasibility Of Small Modular Reactor Deployment On Islands In Southeast Asia And The Pacific, Hayden C. Beauchemin Jan 2026

Assessing The Feasibility Of Small Modular Reactor Deployment On Islands In Southeast Asia And The Pacific, Hayden C. Beauchemin

CMC Senior Theses

This study looks at the feasibility of using Small Modular Reactors (SMRs) to provide island microgrids in Southeast Asia and the Pacific with clean, reliable electricity. SMRs are compared to current methods of electricity generation, namely diesel generators, as well as to renewable alternatives. Policymakers will face geopolitical, technical, economic, and domestic political challenges to SMR deployment. The key considerations of SMRs, including economic viability, safety approaches, public attitudes, and diplomatic relations are considered, and solutions are identified for issues such as financing and nuclear waste disposal. The analysis reinforces the conclusion that SMR deployment is feasible for islands in …


Do The Oscars Move Markets? Best Picture Recognition And Public Equity Responses, Avi Dayani Jan 2026

Do The Oscars Move Markets? Best Picture Recognition And Public Equity Responses, Avi Dayani

CMC Senior Theses

This thesis examines when culturally salient events become financially material by testing whether Academy Awards recognition is reflected in public equity markets. The central question is whether Best Picture nomination announcements and wins generate abnormal returns or abnormal trading activity for the publicly traded parent firms linked to nominated films, and whether those responses depend on the firm’s exposure to filmed entertainment. I study Best Picture nominees from 2000 through 2024, map each film to the public parent of its primary distributor, and construct a firm-by-Oscar-year sample of 119 observations. Using an event-study framework, I calculate abnormal returns as firm …


Intermittent High-Fat, High-Sugar Access During Adolescence Drives Binge-Restriction Feeding And Reduced Weight Gain In A Food Unpredictability Model, Calvin G. Miller Jan 2026

Intermittent High-Fat, High-Sugar Access During Adolescence Drives Binge-Restriction Feeding And Reduced Weight Gain In A Food Unpredictability Model, Calvin G. Miller

CMC Senior Theses

Food insecurity affects nearly 48 million Americans and 318 million people worldwide, with very low food security disrupting normal eating habits through “feast-or-famine” episodes characterized by cycles of food overconsumption followed by restriction. This dietary pattern alters dopamine signaling within the mesocorticolimbic system — brain circuitry intimately linked to reward processing. This system includes the ventral tegmental area (VTA) and prefrontal cortex (PFC). Overstimulation can be promoted through sporadic high-fat, high-sugar diet (HFHSD) exposure, promoting dopamine neuron architecture alterations and binge-eating behavior. Adolescence represents a vulnerable window, as mesocorticolimbic dopamine projections undergo maturation during this period. Though evidence links food …