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Articles 5311 - 5340 of 2929954
Full-Text Articles in Entire DC Network
Spatial Control Of Parathyroid Hormone Receptor-1 Signaling Dictates Ligand-Specific Biological Outcomes, Jakob Höppner, Harald Jüppner, Monica Reyes, Prem Swaroop Yadav, Dian Wang, Thomas Dean, Patrick Hanna, Roberto Civitelli, Asuka Inoue, Ernestina Schipani, Ignacio Portales-Castillo, Thomas J Gardella
Spatial Control Of Parathyroid Hormone Receptor-1 Signaling Dictates Ligand-Specific Biological Outcomes, Jakob Höppner, Harald Jüppner, Monica Reyes, Prem Swaroop Yadav, Dian Wang, Thomas Dean, Patrick Hanna, Roberto Civitelli, Asuka Inoue, Ernestina Schipani, Ignacio Portales-Castillo, Thomas J Gardella
2020-Current year OA Pubs
Parathyroid hormone receptor-1 (PTH1R) is a class B GPCR that regulates mineral ion homeostasis via parathyroid hormone (PTH) and skeletal development via parathyroid hormone-related peptide (PTHrP). While PTHrP signaling is thought to occur predominantly at the plasma membrane, PTH is considered to also signal from endosomes; however, the mechanisms that encode subcellular PTH1R actions, as well as the biological relevance of plasma membrane vs internalized PTH1R activation, remain unclear. Here, by examining the Eiken syndrome mutant R485X-PTH1R, in which C-tail truncation removes key βarrestin docking sites, we identified βarrestins as critical modulators of compartmentalized PTH1R signaling in response to endogenous …
Molecular Signaling Pathways, Regulatory And Coactivator Networks, And Emerging Mechanisms In Hepatocellular Carcinoma, Rohit K Srivastava, Pratibha Singh, David M Lonard
Molecular Signaling Pathways, Regulatory And Coactivator Networks, And Emerging Mechanisms In Hepatocellular Carcinoma, Rohit K Srivastava, Pratibha Singh, David M Lonard
Faculty, Staff and Students Publications
Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and a leading cause of cancer-related mortality worldwide. Despite advances in diagnosis and therapy, the prognosis for advanced HCC remains poor due to late-stage diagnosis, high recurrence rates, therapeutic resistance, and pronounced molecular heterogeneity. HCC development is driven by complex somatic gene alterations, epigenetic reprogramming, dysregulated signaling pathways, metabolic changes, and an immunosuppressive tumor microenvironment. Molecular profiling studies have identified key oncogenic pathways involved in HCC progression, including MAPK/ERK (mitogen-activated protein kinase/extracellular signal-regulated kinase), Wnt/β-catenin, PI3K/AKT/mTOR (Phosphoinositide 3-kinase/Protein Kinase B/mechanistic Target of Rapamycin), Hippo-YAP/TAZ, (Yes-associated protein/transcriptional co-activator with PDZ-binding motif) …
Engineering Circular Rna Expression Systems To Minimize Contaminating Linear Rna Byproducts, Christopher J Fields, Rina Fujiwara, Bradley W Wright, Brett W Stringer, Simon J Conn, Jeremy E Wilusz
Engineering Circular Rna Expression Systems To Minimize Contaminating Linear Rna Byproducts, Christopher J Fields, Rina Fujiwara, Bradley W Wright, Brett W Stringer, Simon J Conn, Jeremy E Wilusz
Faculty, Staff and Students Publications
Circular RNAs (circRNAs) are generated by backsplicing of eukaryotic protein-coding transcripts and can regulate microRNAs and RNA binding proteins, or serve as translation templates. Their covalently closed structure confers resistance to exonuclease-mediated degradation, extending their half-life and supporting their development as RNA therapeutics. However, existing overexpression methods often yield substantial contaminating linear RNAs, limiting their utility. Here, we systematically benchmarked plasmid-based circRNA overexpression strategies in human cells, comparing spliceosome- and ribozyme-based mechanisms across constructs incorporating widely used flanking sequences. The ribozyme-based Tornado system produced the highest circRNA yield but introduced extraneous “molecular scars” into the mature product. By contrast, spliceosome-mediated …
Incipient Buckling Detection Using Nonlinear System Identification Algorithms: A Comparative Study, Raymond Andrew Swartz, Padmanabh Shridhar Desai
Incipient Buckling Detection Using Nonlinear System Identification Algorithms: A Comparative Study, Raymond Andrew Swartz, Padmanabh Shridhar Desai
Michigan Tech Publications
Structural health monitoring detects and characterizes damage to predict failure, but failures like buckling, which lack signs of damage, are harder to detect. Direct load measurement is costly and complex, especially for dead loads requiring copious sensors and data acquisition hardware. Vibration-based detection is a good alternative because it infers global structural characteristics with fewer sensors. This paper presents a structural health monitoring approach for the detection of incipient buckling in structures due to excessive load conditions. Existing nonlinear modeling algorithms available in commercial software platforms, such as MATLAB and other open-source toolboxes, are leveraged to make this method potentially …
Racial Discrimination And Its Effects On Health And Maternal Mortality, Vanessa Newsome-Slade
Racial Discrimination And Its Effects On Health And Maternal Mortality, Vanessa Newsome-Slade
Fresh Voices: Composition at Cal Poly
No abstract provided.
The Poisoning Of Flint’S People, Vanessa Lamoureux
The Poisoning Of Flint’S People, Vanessa Lamoureux
Fresh Voices: Composition at Cal Poly
No abstract provided.
The Death Of Marilyn Monroe, Kaylee Earnshaw
The Death Of Marilyn Monroe, Kaylee Earnshaw
Fresh Voices: Composition at Cal Poly
No abstract provided.
Plastics Are Out: Reusables Are In, Anna Wannenwetsch
Plastics Are Out: Reusables Are In, Anna Wannenwetsch
Fresh Voices: Composition at Cal Poly
No abstract provided.
The Stacks, Alexander Watkins
The Stacks, Alexander Watkins
Fresh Voices: Composition at Cal Poly
No abstract provided.
Undocumented And Unafraid, Claudia
Undocumented And Unafraid, Claudia
Fresh Voices: Composition at Cal Poly
No abstract provided.
Menstruation Nation: Let’S Free The Tampons, Holly Masterson
Menstruation Nation: Let’S Free The Tampons, Holly Masterson
Fresh Voices: Composition at Cal Poly
No abstract provided.
How Does Language Learning Work?, Luis Wiley
How Does Language Learning Work?, Luis Wiley
Fresh Voices: Composition at Cal Poly
No abstract provided.
Eyes For The Dark, Stephanie Mullen
Eyes For The Dark, Stephanie Mullen
Fresh Voices: Composition at Cal Poly
No abstract provided.
Curving Our Enthusiasm: The Downsides Of Grading Curves, Kevin Lee
Curving Our Enthusiasm: The Downsides Of Grading Curves, Kevin Lee
Fresh Voices: Composition at Cal Poly
No abstract provided.
Comfort V. Necessity, Bryanna Gay
Comfort V. Necessity, Bryanna Gay
Fresh Voices: Composition at Cal Poly
No abstract provided.
Cal Poly Needs More Composting, Sarah Bates
Cal Poly Needs More Composting, Sarah Bates
Fresh Voices: Composition at Cal Poly
No abstract provided.
Voter Registration, Kayla Cheyno
Voter Registration, Kayla Cheyno
Fresh Voices: Composition at Cal Poly
No abstract provided.
Blinded By The Bubble, Jaxon Silva
Blinded By The Bubble, Jaxon Silva
Fresh Voices: Composition at Cal Poly
No abstract provided.
Bodily Movement, Laura Nelson
Bodily Movement, Laura Nelson
Fresh Voices: Composition at Cal Poly
No abstract provided.
The Og Feminist: Queen Elizabeth I, Leanna Mcmahon
The Og Feminist: Queen Elizabeth I, Leanna Mcmahon
Fresh Voices: Composition at Cal Poly
No abstract provided.
The King Of Rhetoric, Jose Mendez
The King Of Rhetoric, Jose Mendez
Fresh Voices: Composition at Cal Poly
No abstract provided.
Ethos, Pathos And Logos In ‘We Need To Talk About An Injustice', Fiona Cullen
Ethos, Pathos And Logos In ‘We Need To Talk About An Injustice', Fiona Cullen
Fresh Voices: Composition at Cal Poly
No abstract provided.
Race And The Evaluation Of Nfl-Ready Quarterbacks, Thomas Mctygue
Race And The Evaluation Of Nfl-Ready Quarterbacks, Thomas Mctygue
Fresh Voices: Composition at Cal Poly
No abstract provided.
Catching Fire, Alex Cushing
Catching Fire, Alex Cushing
Fresh Voices: Composition at Cal Poly
No abstract provided.
Eat. Sleep. Lift. Repeat., Jaymi Boynton
Eat. Sleep. Lift. Repeat., Jaymi Boynton
Fresh Voices: Composition at Cal Poly
No abstract provided.
Los Sauces: A People And Place Defined By Time, Marissa Zamudio
Los Sauces: A People And Place Defined By Time, Marissa Zamudio
Fresh Voices: Composition at Cal Poly
No abstract provided.
Understanding The Abandoned: An Educator’S Immersive Approach, Mackenzie Croxdale
Understanding The Abandoned: An Educator’S Immersive Approach, Mackenzie Croxdale
Fresh Voices: Composition at Cal Poly
No abstract provided.
Living In Eden, Alex Cushing
Living In Eden, Alex Cushing
Fresh Voices: Composition at Cal Poly
No abstract provided.
Welcome To My Journey, Valeria Salazar
Welcome To My Journey, Valeria Salazar
Fresh Voices: Composition at Cal Poly
No abstract provided.
Halves, Laura Kuffner