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Articles 51121 - 51150 of 2913340
Full-Text Articles in Entire DC Network
Leveraging Ai, Iot, And Predictive Analytics For Crisis Management And Urban Resilience In Dubai, Suhail Bin Kalli
Leveraging Ai, Iot, And Predictive Analytics For Crisis Management And Urban Resilience In Dubai, Suhail Bin Kalli
Theses
The thesis will discuss how smart technologies could be incorporated in the crisis management structures of Dubai to make the city more resilient. As Dubai grows more urbanized, it experiences increased problems with managing its crisis especially in the high population density places, traffic congestion, utility disruption, and extreme weather. This paper discusses how artificial intelligence (AI), the Internet of Things (IoT), and predictive analytics can be used to ameliorate the response to emergencies, manage the allocation of resources, and enhance the coordination between different agencies. The crisis management systems at Dubai are still ineffective despite the level of technologies …
Optimizing Marketing Campaigns To Maximize The Response Rate For A Supermarket Using Machine Learning Techniques, Alia Almansoori
Optimizing Marketing Campaigns To Maximize The Response Rate For A Supermarket Using Machine Learning Techniques, Alia Almansoori
Theses
Supermarkets must improve their marketing tactics at a time of changing consumer behavior and increasing competition in the retail industry. Engaging the wide and sophisticated consumer base of today's supermarkets is difficult using traditional methods. This proposal presents a data-driven approach using cutting-edge machine learning methods to enhance supermarket marketing strategies. The main goal is to increase the response rate of marketing initiatives, which will improve consumer engagement and ultimately increase revenue. Additional primary objectives are customer segmentation and targeting, predictive modeling, personalization, ongoing performance monitoring, and ROI evaluation. The current problem centers around personalization and accuracy. Due to the …
The Effects Of Inadequate Training On Knowledge Management Systems: Retention Crisis Of Captains In The United States Army, Lexis R. Grudzinski
The Effects Of Inadequate Training On Knowledge Management Systems: Retention Crisis Of Captains In The United States Army, Lexis R. Grudzinski
Theses and Dissertations
This research explores the relationship between the United States Army’s communication strategy in knowledge management for officers and the desires of captains to continue serving beyond their service obligation. Amidst the current retention crisis (Winkie, 2023) at the captain rank, blame often falls on factors outside of the Army’s control. This research, however, seeks to investigate a factor within the Army’s control and offer workable solutions.
For this research, we will use the common definition of knowledge management (KM): the process of creating, capturing, and organizing knowledge within an organization in a way that improves efficiency. KM includes both explicit …
Literacy Intervention At The Middle Level: A Mixed-Methods Examination Of The Implementation Of Thinking Maps, Ashley Chantal Choice
Literacy Intervention At The Middle Level: A Mixed-Methods Examination Of The Implementation Of Thinking Maps, Ashley Chantal Choice
Theses and Dissertations
This study examined the implementation of Thinking Maps® as a literacy instructional intervention for students in grades four and five. Using an explanatory sequential mixed-methods design, the study investigated the effect of Thinking Maps® on student achievement, changes in students’ literacy-related work products, and teachers’ perceptions of the strategy. The study was conducted at a rural Title I elementary school in the southeastern United States and included nine teachers and 150 students across English language arts, mathematics, science, and social studies during an eight-week intervention period. Quantitative data included unit pretest and posttest scores from standards-aligned assessments and teacher perception …
Why Stay? A Qualitative Case Study Of Parents Who Choose Local Public Schools Over Alternative Options, Michael Antonio Scott
Why Stay? A Qualitative Case Study Of Parents Who Choose Local Public Schools Over Alternative Options, Michael Antonio Scott
Theses and Dissertations
Public schools face challenges that directly impact the quality of education and educational programming. Declining student enrollment trends affect school funding and resource allocation for school improvement. This qualitative case study identified key factors influencing parents' perceptions of school quality and explored how these perceptions shaped school choice decision-making. Guided by Rational Choice Theory, the study examined how individuals make enrollment decisions by weighing perceived costs, benefits, constraints, and available resources to achieve desired educational outcomes. Semi-structured interviews, an open-ended survey, and archival school performance data were used to explore the perspectives of parents with children enrolled in public high …
The Relationship Of Federal Title V Funding To Retention And Graduation Rates Of Hispanic-Serving Institutions In The Southeastern United States, Julio Cesar Llanos Jr.
The Relationship Of Federal Title V Funding To Retention And Graduation Rates Of Hispanic-Serving Institutions In The Southeastern United States, Julio Cesar Llanos Jr.
Theses and Dissertations
The number of Latino/a or Hispanic students, also known as Latinx students, are expected to grow demographically in various regions of the United States over the next several years. To ensure Latinx students are progressing toward graduation in their respective cohorts, it may be beneficial to anticipate and prepare for the increase in this student demographic. This study focused on institutions in the Southeastern region of the United States. This study compared the relationship of federal Title V funding and retention rates and graduation rates of students; it also compared degrees awarded to Hispanic students and enrollment of Hispanic students …
The Nfl’S Collision With Antitrust Law: A Strategy For Defending The National Football League’S Joint Agreements With Streaming Providers, Jack Mays
Chapman Law Review
The next frontier of sports broadcasting is here. Media consumption has shifted dramatically in recent years. Streaming services have become the preferred medium for television shows and movies, and sports broadcasts have expanded beyond traditional cable to streaming services. Given this reconfiguration of public behavior, the Sports Broadcasting Act (SBA)—a 1961 exemption to antitrust law—should be construed to allow the National Football League (NFL) to collectively negotiate with streaming providers like Amazon Prime Video, Peacock, and Netflix.
The SBA exempts joint agreements between professional sports leagues and broadcasters from antitrust scrutiny when those agreements involve the “sponsored telecasting” of games. …
Part 1: Experiences - In Shakers At The Center: Manifesting Spirits & Spectacles In Nineteenth-Century America, Douglas L. Winiarski
Part 1: Experiences - In Shakers At The Center: Manifesting Spirits & Spectacles In Nineteenth-Century America, Douglas L. Winiarski
Religious Studies Faculty Publications
Two months after the “painful opperation” in which an angel cut the bloody “secret interests” from her heart, Eunice Bathrick became an instrument. It was the answer to her most fervent prayers.
William Taylor Muse Law Library Annual Report 2025-2026, William Taylor Muse Law Library
William Taylor Muse Law Library Annual Report 2025-2026, William Taylor Muse Law Library
Muse Law Library Annual Reports
No abstract provided.
Green Synthesis Of Tio2 Nanoparticles Via Graphene Oxide-Doped Malabar Spinach Leaf Extract For Perovskite Solar Cells, Nofrijon Sofyan, Ichsan Pandu Wicaksono, Fiona Angellinnov, Aga Ridhova, Akhmad Herman Yuwono, Donanta Dhaneswara
Green Synthesis Of Tio2 Nanoparticles Via Graphene Oxide-Doped Malabar Spinach Leaf Extract For Perovskite Solar Cells, Nofrijon Sofyan, Ichsan Pandu Wicaksono, Fiona Angellinnov, Aga Ridhova, Akhmad Herman Yuwono, Donanta Dhaneswara
Baghdad Science Journal
This study investigates a green synthesis route for titanium dioxide (TiO2) nanoparticles (NPs) using Malabar spinach (Basella rubra) leaf extract, with graphene oxide (GO) as a dopant, for application as an electron transport layer in perovskite solar cells (PSCs). The synthesized TiO2 NPs were characterized using Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), ultraviolet-visible diffuse reflectance spectroscopy (UV-Vis DRS), and field emission scanning electron microscopy equipped with energy dispersive X-ray spectroscopy (FESEM/EDX). XRD results confirmed the presence of a pure anatase phase with a smaller crystallite size than that of commercial TiO2, …
Influence Of Solvent Type On The Morphology And Mechanical Properties Of Electrospun Pmma Nanofibers, Mohd Khairulniza Mansor, Ahmad Faiza Mohd, Khairunnadim Ahmad Sekak, Norhanifah Mohd Yazid, Nurul Fatahah Asyqin Zainal, Yong Kok Chong
Influence Of Solvent Type On The Morphology And Mechanical Properties Of Electrospun Pmma Nanofibers, Mohd Khairulniza Mansor, Ahmad Faiza Mohd, Khairunnadim Ahmad Sekak, Norhanifah Mohd Yazid, Nurul Fatahah Asyqin Zainal, Yong Kok Chong
Baghdad Science Journal
Electrospinning is a versatile and widely used technique for producing nanofibers with controlled morphology and high surface area, essential for applications in filtration, biomedical engineering, and sensors. The choice of solvent plays a crucial role in determining the efficiency of the electrospinning process and the properties of the resulting fibers. In this study, poly(methyl methacrylate) (PMMA) nanofibers were fabricated via electrospinning using four different solvents: tetrahydrofuran (THF), dimethylformamide (DMF), chloroform (CHCl3), and acetone at a 20% (w/w) polymer concentration. Surface tension tests revealed that DMF exhibited the highest surface tension, at 40.11 mN/m, which influenced fiber formation. Electrospinning …
Effect Of Demineralization And Physical Activation In Enhancing The Porosity And Adsorption Properties Of Recovered Carbon Black Pyrolyzed From Waste Tire, Siti Nuramirah Rabbani Muhammad Zaki, Nurul Fatahah Asyqin Zainal, Hartini Ahmad Rafaie, Suhaila Idayu Abdul Halim, Chia Chay Tay
Effect Of Demineralization And Physical Activation In Enhancing The Porosity And Adsorption Properties Of Recovered Carbon Black Pyrolyzed From Waste Tire, Siti Nuramirah Rabbani Muhammad Zaki, Nurul Fatahah Asyqin Zainal, Hartini Ahmad Rafaie, Suhaila Idayu Abdul Halim, Chia Chay Tay
Baghdad Science Journal
This research aims to improve the porosity structure and adsorption characteristics of rCB through demineralization and physical activation techniques. Hydrochloric acid (HCl) at various concentrations (1, 5, 6, and 10 M) was employed for demineralization, followed by the addition of 6 M potassium hydroxide (KOH). Physical activation was conducted at temperature ranges of 300, 350, 400, 450, and 500°C for durations of 1, 2, and 3 h. Characterization of rCB was conducted using Fourier Transform Infrared Spectroscopy (FTIR), ash content analysis, Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES), Brunauer-Emmett-Teller (BET), and iodine adsorption number (IAN). Demineralization decreased the ash content …
Mastering Enterprise Networks (3rd Ed), Mathew J. Heath Van Horn
Mastering Enterprise Networks (3rd Ed), Mathew J. Heath Van Horn
OER Main
Mastering Enterprise Networks, is a comprehensive guide to building, defending, and attacking enterprise networks. It covers a wide range of topics, from network fundamentals to advanced security concepts. The book is well-organized and easy to follow, making it a valuable resource for both beginners and experienced network professionals.
One of the strengths of this book is its focus on hands-on learning. The book includes 50 chapters of labs that allow readers to practice the concepts they have learned. These labs are a great way to reinforce your understanding of enterprise networks while developing practical skills.
This book covers security from …
Gradient-Based, Post-Optimality Sensitivity Analysis With Respect To Parameters Of State Equations, Gene Hou, Jonathan Degroff
Gradient-Based, Post-Optimality Sensitivity Analysis With Respect To Parameters Of State Equations, Gene Hou, Jonathan Degroff
Mechanical & Aerospace Engineering Faculty Publications
Design optimization is a computational tool that can enable a designer to investigate the effectiveness of a design concept in an organized format. However, this design process requires the design variables, constraints, and objective function to be properly defined and expressed in mathematical forms. Post-optimality analysis thus becomes a necessary step to investigate different variations in the problem formulation and parameters to ensure that optimization produces a stable and trustworthy outcome. One efficient way to achieve this aim is to compute the local derivative of the optimized objective function with respect to the optimization problem parameters, such as bounds on …
Uncertainty-Aware Estimation, Planning, And Control For Tracking Multiple Drifting Patches In Flow Fields, Daniel O. Akanji, Krishnanand N. Kaipa, Cong Wei
Uncertainty-Aware Estimation, Planning, And Control For Tracking Multiple Drifting Patches In Flow Fields, Daniel O. Akanji, Krishnanand N. Kaipa, Cong Wei
Mechanical & Aerospace Engineering Faculty Publications
In this study, we present a replay-based framework for uncertainty-aware persistent tracking of multiple advected surface patches using an autonomous marine vehicle operating in spatiotemporal-varying currents. The method combines three components: local flow estimation, covariance-aware patch-boundary propagation with intermittent boundary fusion, and mission-level scheduling over multiple patches. Each patch is represented by a polygonal boundary, whose vertices are propagated through the estimated flow field while carrying per-vertex covariance, thereby quantifying uncertainty growth during advection. A flow-aware gain-scheduled linear quadratic regulator (LQR) was designed to shape the desired surge speed to take advantage of favorable currents. When the vehicle services a …
Influence Of Motion Artifacts On Instantaneous Frequency Based Heart Rate Variability Of Arterial Pulse Signals Measured By A Tactile Sensor: An Analytical Study, Mamun Hasan, Zhili Hao
Influence Of Motion Artifacts On Instantaneous Frequency Based Heart Rate Variability Of Arterial Pulse Signals Measured By A Tactile Sensor: An Analytical Study, Mamun Hasan, Zhili Hao
Mechanical & Aerospace Engineering Faculty Publications
Objective: Heart rate variability (HRV), quantified via the instantaneous frequency (IF) of arterial pulse signals, is a key indicator of cardiovascular (CV) regulation. This study presents a theoretical and experimental investigation of how motion artifacts (MA) influence IF-and thus HRVmeasured with a tactile sensor, emphasizing underlying mechanisms rather than population-level validation. Approach: Building on a previously developed single-degree-of-freedom (SDOF) model of the tissue-contact-sensor (TCS) stack between the sensor and the artery, MA is represented as low-frequency baseline drift and time-varying system parameters (TVSP) of the TCS stack. Analytical expressions quantify the effect of MA on the IF of each harmonic …
Mechanical-Medical Convergence In Heart Failure: Artificial Intelligence, Finite-Element Modeling, And 3d Printing For Diagnosis And Prognosis, Quazi Noor E. Sabrina, Quazi Md Zobaer Shah, Quazi Noor E. Sohela, Md Mahabub Hasan Mousum, Md. Moyeen Uddin Chisty, Quazi Md. Akbar Shah
Mechanical-Medical Convergence In Heart Failure: Artificial Intelligence, Finite-Element Modeling, And 3d Printing For Diagnosis And Prognosis, Quazi Noor E. Sabrina, Quazi Md Zobaer Shah, Quazi Noor E. Sohela, Md Mahabub Hasan Mousum, Md. Moyeen Uddin Chisty, Quazi Md. Akbar Shah
Mechanical & Aerospace Engineering Faculty Publications
Heart failure remains a leading cause of global morbidity and mortality, yet routine clinical indices often miss the regional biomechanical disturbances that drive progression and shape treatment response. This State-of-the-Art review examines how finite-element (FE) modeling, additive manufacturing, and artificial intelligence (AI) are converging to improve the diagnosis, phenotyping, procedural planning, and prognostic assessment of heart failure (HF). Although these technologies have matured in structural heart disease and transcatheter intervention research, their greatest translational potential may lie in HF, where patient-specific ventricular remodeling, myocardial stress–strain heterogeneity, valve-ventricular coupling, and device-tissue interaction are incompletely captured by conventional clinical indices. We synthesize …
Meteorological And Air Quality Effects On Bioaerosol Detection Using Wibs-Neo And Ibac-2 In Dublin City, Emma Markey, Jerry Hourihane Clancy, Moisés Martínez-Bracero, José María Maya-Manzano, Raúl Pecero-Casimiro, Eoin Joseph Mcgillicuddy, Gavin Sewell, Roland Sarda-Estève, Andrés M. Vélez-Pereira, David J. O’Connor
Meteorological And Air Quality Effects On Bioaerosol Detection Using Wibs-Neo And Ibac-2 In Dublin City, Emma Markey, Jerry Hourihane Clancy, Moisés Martínez-Bracero, José María Maya-Manzano, Raúl Pecero-Casimiro, Eoin Joseph Mcgillicuddy, Gavin Sewell, Roland Sarda-Estève, Andrés M. Vélez-Pereira, David J. O’Connor
Research Outputs: 2025-Present
This study evaluates the performance of two real-time fluorescence-based bioaerosol sensors, the WIBS-NEO and IBAC-2, operating in urban Dublin, Ireland, and assesses the influence of different meteorological and pollution parameters on their outputs. This was done by comparing particle sensor data to meteorological variables and air quality metrics. Over the 41-day campaign, Urticaceae pollen and Cladosporium spores were the dominant bioaerosols recorded, comprising 78% and 66% of total pollen and fungal spore concentrations, respectively. Correlation analyses revealed several significant variables: fluorescent BC-type particles (>8 μm) detected by WIBS-NEO strongly correlated with pollen concentrations (r = 0.84 after excluding high-wind …
Code-Net++: An Attention-Guided Deep Learning Framework With Grad-Cam-Based Explainability For Covid-19 Detection Using Chest X-Ray Images, Fareesa Amina, Dr Krishnanaik Vankdoth
Code-Net++: An Attention-Guided Deep Learning Framework With Grad-Cam-Based Explainability For Covid-19 Detection Using Chest X-Ray Images, Fareesa Amina, Dr Krishnanaik Vankdoth
Mansoura Engineering Journal
Chest radiograph imaging has emerged as a practical and scalable diagnostic modality for respiratory diseases, including COVID-19. However, accurate discrimination of COVID-19 manifestations from other pulmonary abnormalities remains challenging because of low contrast, imaging noise, and overlapping radiographic patterns. This work presents CODE-NET++, an enhanced attention-guided deep learning framework with Grad-CAM-based explainability for reliable COVID-19 detection using chest X-ray images. The proposed framework integrates adaptive trilateral filtering for image enhancement, Reverse Edge Attention Network (RE-Net) for lesion-aware segmentation, and an Enhanced LinkNet architecture with dilated convolutions for multiscale feature extraction and classification. Grad-CAM-based explainable artificial intelligence visualization is incorporated to …
A Hybrid Object Detection And Temporal Attention Framework For Intelligent Video Surveillance, Sudheer Reddy Bandi, Eswari Vanaparthi, Yakshini Edapalli, Roshan Kavuri
A Hybrid Object Detection And Temporal Attention Framework For Intelligent Video Surveillance, Sudheer Reddy Bandi, Eswari Vanaparthi, Yakshini Edapalli, Roshan Kavuri
Mansoura Engineering Journal
The rapid growth of urban areas has greatly heightened the need for smart video surveillance systems that can automatically process extensive amounts of CCTV footage. Traditional surveillance methods largely depend on human monitoring, which is not only inefficient but also susceptible to human mistakes, especially in intricate and crowded environments. To tackle these issues, this paper introduces a combined object detection and temporal attention for intelligent video surveillance that concurrently analyzes spatial and temporal data from video streams. The proposed system analyzes real-time CCTV footage utilising a multi-pathway frame extraction technique that includes slow, fast, and full-frame sampling to capture …
University Of Central Florida Graduate Catalog, 2025-2026, University Of Central Florida
University Of Central Florida Graduate Catalog, 2025-2026, University Of Central Florida
UCF Catalogs
No abstract provided.
Debauchery And Decorative Art: Framing The Relationship Between Dining And Material Culture In British Country And Town House Dining Rooms During The Long 18th Century, Guoyang Sun
MA in Fine and Decorative Art and Design Dissertations
This dissertation explores the profound effect of material culture and rituals in elite British dining interiors during the long eighteenth-century. As spaces greatly influenced by the process of museumification, they are often perceived by contemporary and historical observers as settings intended for the ostentatious display of family lineage, taste and affluence. The dining rooms of British Georgian formal houses were highly curated proto museums with huge potential for display through architectural expressions, artworks and decorative objects, however, they were more importantly extremely complex environments that require complete analysis from multiple disciplines and perspectives.
In framing the intimate relationship between dining …
Making The Invisible Visible: How Contemporary Artists Depict The Climate Crisis Through Visual And Conceptual Strategies, Isabella Ray
Making The Invisible Visible: How Contemporary Artists Depict The Climate Crisis Through Visual And Conceptual Strategies, Isabella Ray
MA in Contemporary Art Dissertations
This dissertation examines how contemporary artists depict the environmental consequences of climate change through visual and conceptual strategies. Through the examination of different artworks: Olafur Eliasson’s Ice Watch (2014-2018) and Your Waste of Time (2006), John Gerrard’s Western Flag (Spindletop, Texas) (2017), and Mary Mattingly’s Waterpod (2009) and Swale (2016-2020), this research analyzes how site, material choice, and civic participation create ecological awareness and model possible futures. Eliasson’s installations prompt phenomenological engagement with melting glacial ice and temporalities beyond human perception; Gerrard’s real-time simulations critique humanity’s dependence on fossil fuels through the digital presentation of a perpetual burning flag; Mattingly’s …
On Liminality: Rachel Whiteread & Archiving The In-Between, Natalie Emmerman
On Liminality: Rachel Whiteread & Archiving The In-Between, Natalie Emmerman
MA in Contemporary Art Dissertations
This dissertation examines the sculptural practice of Rachel Whiteread (b. 1963) through the lens of liminality, the uncanny, and the archive. By casting the negative spaces of everyday objects, domestic interiors, and monumental architecture, Whiteread materializes absence and transforms overlooked objects and spaces into solid, lasting forms. Her work destabilizes binary categories such as presence and absence, private and public, representation and abstraction, and permanence and ephemerality, exposing memory as fragile, discontinuous and often ghostly. Drawing on theoretical frameworks rooted in psychoanalysis, photography, time and space, this study explores Whiteread’s practice as a form of sculptural archivization.
Analysis is structured …
Impacts Of Teacher Leadership On K-12 Teachers, School Communities, And Students, Jordan Birkeland
Impacts Of Teacher Leadership On K-12 Teachers, School Communities, And Students, Jordan Birkeland
All Electronic Theses and Dissertations
In K-12 education today, teachers are frequently being called upon to lead. Not only are they receiving increasingly more responsibilities, but they are relied upon more to support students and fellow staff in a variety of ways. Therefore, it is important to understand if the development and utilization of teacher leadership is a necessary method to provide schools with a way to support educators and other stakeholders. This literature review explores how teacher leadership is defined and practiced relative to the prevailing leadership models used in K-12 education, and identifies the impacts of teacher leadership on grades K-12 teachers, school …
Objective Assessment In Experiential Learning Contexts, Lily M. Brutger
Objective Assessment In Experiential Learning Contexts, Lily M. Brutger
All Electronic Theses and Dissertations
Experiential learning is widely recognized as a powerful approach to education; however, empirical evidence demonstrating its effectiveness remains limited. This gap in the literature is due less to the value of experiential learning itself than to the challenges of assessing learning within experiential contexts. Drawing on the foundational experiential learning theories of Kolb (1984) and Joplin (1981), as well as contemporary research on assessment validity and practice, this paper examines the relationship between assessment and experiential learning. It argues that purposeful, objective assessment is essential for maximizing student learning and supporting the credibility of experiential education. The paper synthesizes current …
Teaching Primary Sources To Increase Engagement And Build Literacy, Lindsey L. Beaulieu
Teaching Primary Sources To Increase Engagement And Build Literacy, Lindsey L. Beaulieu
All Electronic Theses and Dissertations
This thesis reviews the use of primary sources in education. This literature review analyzes 30 articles regarding educators’ use of primary sources. There are four major themes within the articles: literacy with primary sources, engagement with primary sources, comprehension with primary sources, and examples of primary source units or lessons. While specific teaching topics vary, the overall consensus is that primary sources can help students’ skills with literacy, engagement, and comprehension. A main topic among the research is the educators’ understanding of scaffolding, pre-teaching, choosing primary sources, and re-using the primary sources, to be able to teach students effectively.
Meconium Metal Concentrations And Infant Temperament And Development, Fiona Fogarty
Meconium Metal Concentrations And Infant Temperament And Development, Fiona Fogarty
Dissertations and Theses
BACKGROUND: Prenatal exposure to metals poses significant health consequences for early childhood development. Understanding the factors influencing metal concentrations that infants are exposed to in-utero is crucial for developing targeted interventions, particularly when maternal characteristics and environmental factors, may contribute to varying levels. Meconium offers insight into in-utero exposures for the developing infant, and the effect of each individual metal may be mediated or exacerbated by another and therefore should be studied in the context of a mixture. The effect of metal mixture exposure, as measured in meconium, on milestone and temperament outcomes has yet to be determined.
DESIGN: …
An Engine, Not A Vessel: Place, Politics, And Health In The United States, Philip B. Rocco
An Engine, Not A Vessel: Place, Politics, And Health In The United States, Philip B. Rocco
Political Science Faculty Research and Publications
Social scientists often treat places as containers for social and economic phenomena that shape health outcomes. Yet this analytic practice conceals more than it reveals. Local governments in the United States should be understood as engines of both health promotion and stratification. As the contributions to this symposium suggest, governments not only occupy a formal place in the U.S. public health system, their decisions on everything from housing to transportation infrastructure can also have profound impacts on health outcomes. Local political economies likewise renegotiate the parameters of acceptable health interventions, public understandings of health disparities, and the status of population …
A Thymine Dimer Stalls A High-Fidelity Dna Polymerase By Providing No Template Information In The Same Manner As An Abasic Site, Amanda R. Walsh, Hye Rhee Kim, Lorena S. Beese, Eugene Y. Wu
A Thymine Dimer Stalls A High-Fidelity Dna Polymerase By Providing No Template Information In The Same Manner As An Abasic Site, Amanda R. Walsh, Hye Rhee Kim, Lorena S. Beese, Eugene Y. Wu
Biology Faculty Publications
Cyclobutane pyrimidine dimers are photolesions that form when UV-B irradiation causes adjacent thymine or cytosine bases to covalently bond and can arrest DNA synthesis by replicative polymerases. To gain insight into the effects of cis-syn cyclobutane thymine dimers (T=T) on DNA replication in a model polymerase, we conducted solution and crystallographic studies of the Bacillus DNA polymerase I large fragment (BF) in complex with a T=T-containing template and an incoming dNTP. A thymine dimer lesion blocked nucleotide addition by BF in solution. The crystal structure of the BF-T=T-dATP complex indicated that the thymine dimer is too large to enter the …