Digital Commons Network^™

Logistic-T Multinomial Mixture Model For Clustering For Microbiome Data, Wenshu Dai, Yuan Fang, Sanjeena Subedi

Mathematics & Statistics Faculty Publications

The logistic-normal multinomial distribution has been used for modelling microbiome data obtained from high-throughput sequencing technologies, which are compositional in nature. A logistic-normal multinomial distribution is a hierarchical multinomial distribution that assumes the latent variable which are the additive log-ratio (ALR) transformed proportions in a multinomial distribution follows a Gaussian distribution. Model-based clustering algorithms have also been developed for clustering microbiome data based on the logistic-normal models. However, the Gaussian assumption may violated when the ALR transformed variable exhibit heavy-tailed distributions or has outliers. Our study introduces a novel mixture of logistic-t multinomial models that effectively address these challenges. Utilizing …

Real-World Anti-Amyloid Therapy Beyond Traditional Symptomatic Populations: A Longitudinal Case Series, Jayoung Han, Yuan Fang, Darlingtina Esiaka, Olufunmilola Abraham

Mathematics & Statistics Faculty Publications

Introduction: Anti-amyloid monoclonal antibodies are approved as disease-modifying therapies for early Alzheimer’s disease (AD), but real-world evidence remains limited, particularly among individuals treated during preclinical or minimally symptomatic stages. This study characterized clinical and biomarker trajectories among anti-amyloid therapy recipients across disease stages.

Method: We conducted a longitudinal retrospective case series of three biomarker-positive individuals from the Alzheimer’s Disease Neuroimaging Initiative who received lecanemab or donanemab. Clinical, cognitive, cerebrospinal fluid, plasma biomarker, and amyloid PET data were examined.

Results: In all three cases, most of the observation period preceded anti-amyloid therapy initiation. Clinical trajectories varied by biomarker profile and treatment …

Dextromethorphan And Trace Level Detections Of Dextrorphan In Post-Race Urine Samples – A Case Report And Analysis, Kimberly Brewer, Justin C. Holmes, Clara Fenger, Abelardo Morales-Briceño, Andreas F. Lehner, George A. Maylin, Robert Holland, Levent Dirikolu, Thomas Tobin

Maxwell H. Gluck Equine Research Center Faculty Publications

Dextrorphan is a Phase I equine metabolite of dextromethorphan, a widely used anti-tussive / cough suppressant medication marketed and available in numerous over-the-counter formulations in the United States. Dextromethorphan is an Association of Racing Commissioners International (ARCI) drug class 4 penalty class B substance and a Horseracing Integrity and Welfare Authority (HIWU) CONTROLLED S7 B substance and is regulated as such in horse racing. In horses, dextromethorphan is metabolized to its Phase I metabolite, dextrorphan, which is next glucuronidated and the resultant dextrorphan-glucuronide conjugate then excreted at remarkably high concentrations in equine urine. Dextrorphan is therefore at times identified in …

Increasing Uptake Of Diabetes Self-Management Education And Support (Dsmes) In Rural Kentucky Primary Care Clinics, Mary E. Lacy, Jessica Elliott, Vance Drakeford, Laura Wright, Brent Mckune, Key C. Douthitt, Aaron J. Kruse-Diehr, James W. Keck

Epidemiology and Environmental Health Faculty Publications

Background: Diabetes self-management education and support (DSMES) is an evidence-based intervention that improves outcomes for people with diabetes, but uptake is <10%. We conducted a pilot pragmatic trial to increase DSMES in rural primary care clinics that integrated health information technology with a quality improvement (QI) learning collaborative. Methods: Two healthcare systems from rural Kentucky participated in the study. Within each system, 2 clinics received the intervention and 1 clinic served as a control (N = 6 clinics). Each intervention clinic identified a QI team (5-6 individuals) who participated in a 9-month QI learning collaborative followed by 5 months of follow-up. Our primary outcome was DSMES referrals; secondary outcomes were DSMES attendance and percentage with A1c >9%. Results: The 6 study clinics served 1,803 patients with diabetes; n = 1083 (60.1%) from 4 intervention clinics and n = 720 (39.9%) from 2 control clinics. DSMES referrals significantly increased in the intervention clinics compared to the control clinics (31.7% vs 0.1%, P < .001) and continued to increase throughout 5-month follow-up (40.0% vs 0.1%, P < .001). Conclusions: A structured QI intervention can significantly increase DSMES referral rates in primary care clinics. Findings highlight the potential of systems-level approaches to address persistent gaps in diabetes care delivery in rural settings. Clinical Trial Registry: Using Practice Facilitation and Operationalizing Referral Information Technology to Increase DSMES Utilization (Clinicaltrials.gov registration number no. NCT05472142). Clinicaltrials.gov URL (https://clinicaltrials.gov/study/NCT05472142).

The Association Between Human Papillomavirus Type 16 E6 Seroprevalence And Degrees Of Anal Disease Among Men With Hiv, Krystle A.Lang Kuhs, Christopher Otieno, Staci Sudenga, Tim Waterboer, Weiqun Tong, Dorothy Wiley, Jay H. Bream, Steven Wolinsky, Jeremy Martinson, Gypsyamber D’Souza

Epidemiology and Environmental Health Faculty Publications

Introduction: Human papillomavirus type 16 (HPV16) E6 antibodies may be an early biomarker of anal cancer. We cross-sectionally evaluated when in the course of anal disease, HPV16 antibodies are induced. Methods: A nested case-control study of 846 men who have sex with men (MSM) was conducted within a prospective study of men with and without HIV. Cases of anal HPV16 (N=262), biopsy-confirmed high-grade squamous intraepithelial lesion (HSIL;N=140), and anal cancer (N=21) were individually matched to controls (N=423) on HIV status, study-participation duration, and age. Serum samples closest to diagnosis underwent HPV serologic testing; prediagnostic serial samples were tested for anal …

A Comprehensive Analysis Of Jurisdiction-Specific Laws Related To Scheduling Or Required Prescription Drug Monitoring Of Gabapentin In The United States, 2016–2024, Katherine Gora Combs, Rachel Vickers-Smith, Collin Stewart, Daniel Wacker, Juan M Hincapie-Castillo

Epidemiology and Environmental Health Faculty Publications

Gabapentin prescription use has increased across the United States since the late 2000s. Concerns of potential misuse and growing overdose involvement have led to the passage of jurisdiction-specific policies targeting gabapentin prescribing; however, the current legal landscape of these policies is not well documented or understood. We conducted a comprehensive, longitudinal analysis of policies related to scheduling or required prescription drug monitoring of gabapentin across 51 jurisdictions in the United States from January 2016 through December 2024. Across the study period, 25 jurisdictions (49 %) enacted policies related to gabapentin scheduling or required prescription reporting. Eight (16 %) jurisdictions classified …

Optimizing Control Definitions In Opioid Use Disorder Genetic Research Using Electronic Health Records, Maria Niarchou, Ellen L Tsai, Mariela V Jennings, Annika Faucon, Hyunjoon Lee, Kritika Singh, Justin D Tubbs, Panos Roussos, Tian Ge, Richard C Crist, Rachel Vickers-Smith, Howard Edenberg, Amy Moore, Bradley T Webb, Eric O Johnson, Rachel L Kember, Jordan W Smoller, Lea K Davis, Brandon J Coombes, Georgios Voloudakis, David Burstein, Travis T Mallard, Vanessa Troiani, Sandra Sanchez-Roige

Epidemiology and Environmental Health Faculty Publications

Amidst the opioid crisis, understanding the genetic basis of opioid use disorder (OUD) is crucial for identifying biological mechanisms and intervention points. However, genome-wide association studies (GWASs) have been hampered by inadequate sample sizes and often the use of control populations not assessed for prior opioid exposure. Because opioid exposure is a prerequisite for the development of OUD, consideration of exposure history in controls is important. Electronic health record data (EHR) paired with genomic information allow a broader sampling of patients with OUD and exposed controls. We leveraged data across two healthcare systems to evaluate the impact of using controls …

Shaping The Future Of Human Biomonitoring (Hbm), Maryam Zare Jeddi, Nancy B. Hopf, Karen S. Galea, Kate Jones, Henriqueta Louro, Maria João Silva, Adrian Covaci, Tiina Santonen, Paul T.J. Scheepers, Susana Viegas, Lesliam Quirós-Alcalá, Asif Qureshi, M. Elizabeth Marder, Natalie Von Goetz, Konstantinos M. Kasiotis, Kyriaki Machera, Ovnair Sepai, Radu Corneliu Duca, Manosij Ghosh, An Van Nieuwenhuyse, Ming Kei Chung, Jihyon Kil, Shoji F. Nakayama, Aziza Menouni, Kaoutar Chbihi, Ana Maria Vekic, Gustavo Souza, Maisarah Nasution Waras

Epidemiology and Environmental Health Faculty Publications

Human biomonitoring (HBM) continues to play an indispensable role within exposure science, offering insights into aggregate chemical exposures across populations and life stages. Since 2018, the European chapter of the International Society of Exposure Science Human Biomonitoring Working Group (ISES Europe HBM WG) has aimed to facilitate generation of more and high-quality HBM data. The working group aims to strengthen integration of HBM data into regulatory frameworks through improved study design, harmonized methodologies, and enhanced reporting practices. Key achievements in the past seven years include the harmonization of HBM metadata through development of minimum information requirements for HBM (MIR-HBM), development …

Association Between Educational Attainment And Discharge Disposition Following Incident Stroke Hospitalization, Ning Li, Erin L. Abner, Silvia Koton, Lena Mathews, Kunihiro Matsushita, Anna Kucharska-Newton

Epidemiology and Environmental Health Faculty Publications

Background – The relationship between educational attainment and discharge disposition after stroke hospitalization remains unclear. This study examined whether educational attainment is associated with discharge disposition after incident stroke and whether stroke severity modifies this association. Methods – The study included Atherosclerosis Risk in Communities (ARIC) participants with an incident stroke hospitalization from 1991 to 2020 who were enrolled in fee-for-service (FFS) Medicare at discharge. Discharge disposition was obtained from hospitalization claims. Educational attainment was categorized as “less than high school” vs. “high school or more.” Multivariable logistic regression models were used to estimate associations between educational attainment and discharge …

Building The Ryan White Hiv/Aids Program Bench In Kentucky, Lauren Bifulco, Kathleen Harding, Jana Collins, Anna Rogers, Lenon Farkash, Marwan Haddad, Alice Thornton

Epidemiology and Environmental Health Faculty Publications

The Ryan White HIV/AIDS program (RWHAP) is governed by legislative and programmatic guidelines that ensure comprehensive services are provided to persons with HIV (PWH) across the United States. Comprehensive training and skill building opportunities for programmatic staff are rare. RWHAP funding recipient organizations may struggle to acquire and retain essential program-specific knowledge, with downstream impact on patient care and treatment. We designed a comprehensive 11-session videoconference learning series to improve program staff’s confidence and competence with RWHAP fundamentals. Quantitative pre-vs-post session data were analyzed using Wilcoxon Signed-Rank tests, and qualitative data using thematic analysis. We enrolled 136 staff from 23 …

Decreased Gabapentin Prescription Fills Among Medicaid Enrollees Following State-Level Schedule V Controlled Substance Classification In Kentucky And West Virginia, Katherine Gora Combs, Stephen W. Marshall, Rachel Vickers-Smith, Alan Kinlaw, Nabarun Dasgupta, Juan M. Hincapie-Castillo

Epidemiology and Environmental Health Faculty Publications

Background: Driven by concerns of gabapentin misuse and other harms, Kentucky (KY) and West Virginia (WV) became the first states to classify gabapentin as a schedule V controlled substance in July 2017 and June 2018, respectively. This study examined the association of these policies with gabapentin utilization among Medicaid beneficiaries. Methods: Using a controlled interrupted time series design, we modeled a segmented generalized least squares regression and calculated the immediate and trend changes of gabapentin prescriptions among Medicaid enrollees in 2 states (KY, WV), separately. North Carolina (NC) was used as a control to account for secular changes; there was …

Metabolic Reprogramming Following Mitochondrial Transfer Between Idh2-Mutant Chondrosarcoma Cells And A Normal B-Cell Line, Caleb Wyckoff, Christopher Osgood, Ellen Jing, Michael Stacey

Bioelectrics Publications

Background/Objectives: Chondrosarcoma, glioblastoma, acute myeloid leukemia, chronic lymphocytic leukemia, and cholangiocarcinoma cancers all contain mutations in the gene isocitrate dehydrogenase 2 (IDH2). The mutant IDH2 enzyme metabolizes alpha-ketoglutarate (αKG) into the potent oncometabolite D-2-hydroxyglutarate (D2HG) in the mitochondria of these cancers, leading to altered cellular metabolism. Emerging evidence suggests that mitochondrial transfer between cancer and recipient cells represents an important form of intercellular communication that may influence cellular metabolism. The presence of intercellular TNTs between IDH2-mutant chondrosarcoma cells motivated an investigation into mitochondria-associated physiological changes occurring during an intercellular exchange with immune cells. A mitochondrial transfer is a two-way …

Establishment And Histopathological Characterization Of A Kyse-30 Subcutaneous Xenograft Model Of Esophageal Squamous Cell Carcinoma, Pavel A. Solopov, Alayna Enos, Mantas Silkunas, Giedre Silkuniene, Eleni Zivla, Andrei G. Pakhomov, Olga N. Pakhomova

Bioelectrics Publications

Background/Objectives: Esophageal squamous cell carcinoma (ESCC) is an aggressive malignancy with poor prognosis and limited treatment options, highlighting the need for reliable preclinical models for translational research. Although xenograft models are widely used in cancer biology, systematic characterization of subcutaneous ESCC models under defined implantation conditions remains limited. The objective of this study was to systematically compare implantation conditions and define histopathological and growth-related parameters that enable reproducible tumor establishment while maintaining a practical experimental window for therapeutic studies. Methods: We established and characterized a subcutaneous ESCC xenograft model using human ESCC cell line KYSE-30 implanted into immunodeficient J:NU mice. …

Cxcr6+ Natural Killer Cell Immunotherapy Preserves Cd4+ T Helper Cells In Humanized Mice, Naushad Khan, Kayla Frank, Silke Paust

Faculty Research 2026

Human immunodeficiency virus (HIV) persists despite antiretroviral therapy because long-lived viral reservoirs are not eliminated, and ongoing or rebound infection contributes to progressive loss of CD4⁺ T helper cells. Natural killer (NK) cells can acquire adaptive, antigen-experienced functions, including recall responses to HIV envelope protein, suggesting that defined NK-cell subsets may be therapeutically useful against HIV. Because HIV-responsive adaptive NK-cell activity is enriched among CXC chemokine receptor 6-positive (CXCR6⁺) NK cells, we tested whether CXCR6⁺ NK cells provide enhanced antiviral activity and CD4⁺ T-cell protection compared with CXCR6⁻ NK cells. In co-cultures with HIV-infected …

Legislating Infrastructure: A State-Level Model To Accelerate Endometriosis Research And Women's Health Equity., E T Courtois, L Roy, Jasmina Uvalic, K Mullaj, D Lockshire, D E Luciano

Faculty Research 2026

Impact statement: A legislatively mandated, statewide endometriosis biorepository integrated within a multidisciplinary endometriosis focused program demonstrates how policy-driven infrastructure can integrate education, clinical care, harmonized biobanking, and translational research to address persistent gaps in women's health in the long term. The Connecticut Endometriosis Working Group (EWG), a group of legislators, researchers, patients, health care providers, and advocates, was established in 2021. The EWG met monthly to discuss strategies to address endometriosis and propose endometriosis specific legislation which has been a turning point. Public Acts 22-33 and 23-67 directed the establishment, governance, and annual reporting of a coordinated endometriosis data and …

Integration Of A Neuronal Rnaseq Dataset With The Draft Gryllus Bimaculatus Transcriptome Refines Gene Predictions And Highlights Potential Systematic Response To Injury., Felicia F Wang, Harrison P Fisher, Lisa M Ledwidge, Joel H Graber, Riley A Grindle, Jarod A Rollins, Hadley W Horch

Faculty Research 2026

The cricket Gryllus bimaculatus presents a compelling model for investigating neuroplasticity due to its unusual capability of adult structural reorganization. The molecular pathways underlying these changes remain poorly understood. Here, we reanalyzed RNAseq data, originally collected from deafferented and control prothoracic ganglia one, three, and seven days post-injury, which had previously been used to assemble a de novo transcriptome. In this current analysis, we aligned our original RNAseq data to the publicly available G. bimaculatus draft genome, and used the resulting alignments to refine and update the existing annotations. The integration added 3,868 novel genes, 9,172 new transcript isoforms including …

Identifying Transcriptomic Signatures That Mediate The Causal Effect Of Genotype On Alzheimer's Disease., Simran Kaur, Anna L. Tyler, Giovanna L Durante, Gregory Cary, Gregory W. Carter, J Matthew Mahoney

Faculty Research 2026

The combined effects of thousands of genetic polymorphisms account for Alzheimer's disease (AD) genetic risk. Most AD polymorphisms affect gene expression. Thus, the transcriptome, the set of all gene expression levels for every gene in the genome, is a major mediator between the genotype to phenotype. This study uses genotypes, transcriptomes, and clinical phenotypes to identify the transcriptomic signature that mediates the causal effect of genotype on AD. By utilizing a causal inference method known as high dimensional mediation analysis (HDMA) on the Religious Orders Study/Memory and Aging Project (ROSMAP) longitudinal cohort, the genotype, transcriptome, and phenotype data were reduced …

Editorial: Interdisciplinary Innovations In Car T-Cell Therapy For Autoimmune And Cancer Treatment., Apostolos Zaravinos, Derya Unutmaz, Marko Radic

Faculty Research 2026

No abstract provided.

Il1a Enhances Tnf-Induced Retinal Ganglion Cell Death., Katherine M Andersh, Michael Maclean, Gareth R Howell, Richard T Libby

Faculty Research 2026

Introduction:

A growing body of literature suggests a role for neuroinflammation in retinal ganglion cell (RGC) death in glaucoma. For instance, deficiency of three proinflammatory cytokines, complement component 1, subcomponent q (C1q), interleukin 1 alpha (Il1a), and tumor necrosis factor (Tnf), resulted in significant protection of RGCs after glaucoma-relevant insults. While TNF and C1Q have been extensively investigated in glaucoma-relevant model systems, the role of IL1A in RGCs is not well defined.

Methods:

Eyes of 2–4 month-old C57BL/6J mice or mice deficient in either Jun or Sarm1 were intravitreally injected with IL1A alone, TNF …

Editorial: Interdisciplinary Innovations In Car T-Cell Therapy For Autoimmune And Cancer Treatment., Apostolos Zaravinos, Derya Unutmaz, Marko Radic

Faculty Research 2026

No abstract provided.

Wilson, Issue 02, 2025-26, University Of Northern Iowa. Wilson College Of Business.

Wilson

Contents:

From the Dean --- 3
Auditing Students Learn Emerging Technologies and Real-World Analysis --- 4
How Real Estate Students are Learning Industry Software in the Classroom --- 8
Marketing in the Age of Data --- 14
Building Communities, Shaping Futures --- 18
Data Drives Business Success for UNI Student Entrepreneurs --- 22
Data to Assist in Iowa Stomr Response --- 23
Ethical Considerations of Data Breaches --- 24
How Ethics and Data Management Intersect In Today's Business Climate --- 26
Students Dominate Advertising Competition --- 28
AACSB Supplemental Accounting Accreditation --- 30
A New Era for Business: UNI's Wilson …

An Evaluation Of Aquatic Interventions To Support Increased Physical Fitness Levels For Children With Cerebral Palsy, Grace Kasberger

Cal Poly Humboldt theses and projects

This study was designed to determine the most appropriate aquatic interventions to best improve physical fitness levels in children with cerebral palsy (CP). Children with CP often experience reduced aerobic capacity, muscular strength, and functional mobility, which can limit participation in traditional land-based physical activities such as walking and playing. Aquatic environments provide safe and resistance-based environments that can reduce joint loading, spasticity, and provide training. This systematic review examined a variety of different aquatic interventions (e.g. HIIT, aerobic based, strength training, flexibility, and the Halliwick Method) to improve physical fitness in children with CP. Data collection focused on outcomes …

Nourishing Roots: Supporting Indigenous Food Education In School Gardens, Tatiana Marina Patino Madriaga

Cal Poly Humboldt theses and projects

This project asked: How can a school garden at Hoopa Valley Elementary support Indigenous food education, student well-being, and relational learning? To explore this question, I designed and implemented a garden classroom and facilitated hands-on garden and culinary workshops with students.

The garden was planned in September, built in October, and had plants in the ground by November. Over the course of the project, I facilitated four workshops, one Earth Day community event, and weekly garden classes. Approximately 350 students participated in the garden in some capacity, reflecting broad, school-wide engagement.

Methods included participant observation, documentation of student engagement, and …

"What Power Do We Have?" Community Capacity And Justice In Samoa, California’S Floating Offshore Wind Terminal Development, Lauren Mccall Hart

Cal Poly Humboldt theses and projects

Floating offshore wind (OSW) is a relatively novel technology in the United States, which is positioned to play an integral role in California’s decarbonization strategy. Two federal OSW lease areas have been established off the coast of Northern California, and plans are underway to develop supporting port infrastructure, including the Humboldt Bay Offshore Wind Heavy Lift Marine Terminal (HLMT). The proposed HLMT site is adjacent to communities on the Samoa Peninsula of Humboldt Bay, which currently face socio-environmental vulnerabilities and critical infrastructure gaps. The social implications of OSW port development remain poorly understood, particularly in rural and underserved communities. This …

Weaponized Borders: A Contrapuntal Analysis Of Uneven Humanitarian Aid And Comparative Landscapes, Alex Orla-Bukowski

Cal Poly Humboldt theses and projects

The proliferation of global border regimes has caused an increased level of state violence against humans and the environment. In this thesis I explore how contemporary border regimes propagate myths on human mobility, obstruct humanitarian policy, and weaponize environmental landscapes to sustain state violence while obscuring political responsibility. Building on this, I argue that borders are the source of violence and create systems of vulnerability as a core-function of state making. My research primarily utilizes semi-structured interviews with humanitarian actors and secondary data analysis to trace the testimonies of those subject to state-based harm and explore the gaps in aid …

Beyond The Meter: Frameworks For Evaluating The Broad Spectrum Of Microgrid Benefits, Elias Henderson

Cal Poly Humboldt theses and projects

Community-scale microgrids can create a range of social benefits. These include resilient electricity, cleaner air, decarbonization, and economic development, alongside more qualitative values like energy sovereignty and community self-determination. Many such benefits, however, are illegible to California’s market and regulatory frameworks. This thesis traces this disconnect, with particular attention to grid-edge communities in Northern California.

Microgrid benefits are classified as monetized, modeled, or incommensurable according to their inclusion/exclusion in existing regulatory and revenue mechanisms. To explore each category, a mixed-methods analytic approach is employed, pairing Tribal and stakeholder interviews with the development of a microgrid valuation calculator. This tool is …

Improving Expository Reading Comprehension In College Students, Danielle M. De Lucia, George Noell

Psychology Faculty Publications

This study investigated the impact of the Collaborative Strategic Reading (CSR) method on reading comprehension and psychological well-being among college students, addressing a gap in research on expository reading comprehension at the post-secondary level. A total of 47 students from Introduction to Psychology courses participated in the study. Participants initially completed pre-test assessments, including a cloze test, the Wide Range Achievement Test, and scales for self-worth, depression, anxiety, and stress. Of these, 23 students underwent CSR intervention sessions, conducted over three weeks with bi-weekly 50-minute sessions using their course textbook. Post-intervention data from 44 students were analyzed using repeated-measures ANOVA. …

Reward Deficits In Co-Occurring Social Anxiety And Depression: The Roles Of Anhedonia, Boredom, Loneliness, And Covid-19 Social Restriction, Nathan M. Hager, Alicia L. Milam, Hannah C. Hamrick, Benjamin Swanson, Matt R. Judah

Psychology Faculty Publications

Prior research points toward reward deficits as crucial to the link between social anxiety disorder and major depressive disorder. However, studies have not explored specific types of reward deficits or how social-environmental factors may impact them. The current study examined whether the indirect effects of three reward deficits (anhedonia, boredom, and loneliness) accounted for the connection between social anxiety and depression. Questionnaires were collected in a sample of college students (N = 523) during the first year of the COVID-19 pandemic, allowing examination of environmental stressors (i.e., remote learning and current friend network size) on reward deficits. Indirect effect models …

2026-2029 Strategic Plan, Susan Davies

Documents of the Brain Health Collective

No abstract provided.

Ai Deployment Authorisation: A Global Standard For Machine-Readable Governance Of High-Risk Artificial Intelligence, Daniel Djan Saparning

Student Publications

Modern artificial intelligence (AI) governance lacks a formal, enforceable mechanism for determining whether a given AI system is legally permitted to operate in a specific domain and jurisdiction. Existing approaches-such as model cards, audits, and benchmark evaluations provide descriptive information about model behaviour and training data but do not produce binding deployment decisions with legal or financial force. This paper introduces the AI Deployment Authorisation Score (ADAS). This machine-readable, regulator-grade framework evaluates AI systems across five legally and economically grounded dimensions: Risk, Alignment, Externality, Control, and Auditability, derived from safety engineering, alignment theory, algorithmic accountability, and liability economics. ADAS produces …