Digital Commons Network^™

Genetic Adaptations And Malaria Prophylaxis In Sickle Cell Disease: Reducing Morbidity And Mortality, Fuseina Gimballa

Lynchburg Journal of Medical Science

This study examines the relationship between sickle cell disease (SCD) and malaria, focusing on the benefits and risks of the sickle cell trait, complications associated with SCD, and the impact of malaria infection in endemic regions. The paper emphasizes the importance of antimalarial prophylaxis for patients with SCD living in these areas. Evidence suggests a genetic adaptation in populations exposed to malaria, where a β-globin mutation provides partial protection against infection in individuals with the sickle cell trait. Studies consistently show that heterozygous carriers are largely protected from severe malaria, whereas individuals with homozygous SCD remain highly susceptible, resulting in …

Management Of Difficult Patient Situations, Sangeetha Larsen Mpas, Pa-C

Lynchburg Journal of Medical Science

The purpose of this paper is to provide strategies for clinicians to manage difficult patient interactions. A comprehensive search of PubMed was conducted, identifying articles that identified the root cause of difficult patient interactions and assessed methods for successfully navigating these situations. The term “difficult patient” reflects the interaction of patient behavior, clinician perception, and systemic constraints rather than an inherent patient flaw. Effective management involves reframing difficult behavior as an expression of unmet needs and responding with empathy, active listening, clear boundaries, and collaborative decision-making. System-level strategies reduce patient distress and clinician burnout. Ultimately, the difficult patient represents strained …

Forever Un-Wild: How The Forever Wild Clause “Locks Up” New York’S Closed Correctional Facilities, William Carswell

Pace Environmental Law Review

Article XIV of the New York State Constitution, better known as the “Forever Wild Clause,” enshrines a conservationist ideal into law. The crux of article XIV prohibits the leasing, selling, or exchanging of state-owned land within New York’s Forest Preserve to private entities. Since its inception, this mandate has dictated the State’s approach to management of its Forest Preserve. Whenever New York decides to excise a piece of its Forest Preserve, the cumbersome yet necessary constitutional amendment process is triggered. Renewed attention to this legal requirement is peaking. Since 2009, five former Department of Corrections and Community Supervision sites located …

Surf And Turf: How Litigation Against Concentrated Animal Feeding Operations Can Inform Regulation Of The Aquaculture Industry, Amanda Kapitula

Pace Environmental Law Review

Industrial agriculture dominates the U.S. agricultural industry. On land, animals are stuffed into factory-like facilities, called concentrated animal feeding operations (“CAFOs”), where they are raised to maximize the output of food products. In the process, they produce vast amounts of waste, contaminating surrounding air and water resources. Increasingly, factory farms are making their way into the water as the fishing industry shifts from wild-catch systems to aquaculture operations, or the raising of fish for consumption. While aquaculture has the potential to be a more sustainable option than both wild-catch and animal agriculture, concentrated aquatic animal production facilities (“CAAPFs”) also have …

Climate Preemption And Fossil Fuel Entrenchment, Vincent Nolette

Pace Environmental Law Review

Mitigating the worst impacts of climate change demands a rapid reduction in greenhouse gas emissions and a transition to renewable, low-carbon sources of energy. This requires building thousands of gigawatts of clean energy at an unprecedented rate and expeditiously retiring existing fossil fuel infrastructure. Yet both parts of this task have been obstructed by state legislative efforts over the last decade—particularly in Republican-led states—to block local governments from reducing greenhouse gas emissions while legally mandating continued fossil fuel reliance. These efforts are accomplished through state climate preemption laws. Framed in neutral or positive terms like “energy choice,” the actual effect …

Returning To Roots: A Self-Study Of Married Faculty Transitioning To Faculty Roles At Alma Maters, David Wolff, Melissa Wolff, Mark Diacopoulos

The Interactive Journal of Global Leadership and Learning

This self-study explores the transition of two faculty members returning to teach at their alma maters. Using visual methods, reflective journals, and peer dialogue, the researchers documented their experiences over six months. Triangulated data revealed eight themes, including: Identity Formation, Shifting Perspectives from Student to Faculty, Interpersonal Attunement, Navigating Changes, Memories Shape Perception, Occupational Stressors Impacting Transitions, Student Advocacy, and Personal Growth. The study highlights how personal and professional identities evolve during career transitions, and how reflective practices can deepen understanding of adaptation in higher education. These findings contribute to the literature on faculty development and offer insight into the …

Models Of Care In Higher Education: Comparing Integrated And Standalone Approaches To Student Mental Health, Tevia Q. Strand

The Interactive Journal of Global Leadership and Learning

This qualitative study examines how the organization of campus mental health services—integrated, co-located care versus standalone counseling centers—shapes college students’ awareness, access, stigma/privacy, and engagement. Semi-structured interviews with five Midwestern undergraduate women (n = 5) explored perceptions of visibility, ease of use, barriers, and improvement ideas. Transcripts were analyzed using reflexive thematic analysis. Themes included confusion about entry pathways, visibility-related stigma, and the salience of faculty/peer bridges to services. Students generally preferred integrated models, citing privacy through co-location, normalization, and easier warm handoffs; some noted that standalone centers can feel more specialized yet risk heightened visibility depending on location. Findings …

Redefining Rural School Leadership In The Post-Pandemic Era: Lessons From Covid-19, Brennan Kent

The Interactive Journal of Global Leadership and Learning

The COVID-19 pandemic fundamentally reshaped educational leadership, especially in rural school settings where leaders confronted unique resource constraints, geographic isolation, and heightened community interdependence. This conceptual study reexamines rural educational leadership in the post-pandemic era through a synthesis of findings from Author’s (2023) dissertation, The Rural Education Leadership Experience Amid the COVID-19 Pandemic, and current leadership theory. Drawing on the McREL Balanced Leadership Framework alongside adaptive and servant leadership models, the analysis identifies four interrelated dimensions that define post-pandemic rural leadership: communication as community cohesion, relationships as infrastructure, adaptive leadership as necessity, and well-being as a leadership priority. These …

Voices From The Other Side: Leadership Practices Teachers Value For Equity Systems Change, Heather L. Dunham, Heather Dunham

The Interactive Journal of Global Leadership and Learning

A growing body of scholarship has explored leadership for equity through frameworks such as social justice leadership (Theoharis, 2010), culturally responsive leadership (Khalifa et al., 2016), and equity audits (Skrla & Scheurich, 2004). Yet, these efforts often target isolated symptoms of inequity—achievement, discipline, or inclusion—rather than engaging in systemic reform that addresses both the ostensive and performative routines sustaining racialized practices. This study centers the Integrated Comprehensive Systems (ICS) for Equity framework (Capper & Frattura, 2017) to examine teachers’ perspectives on leadership practices that support organizational equity systems change.

Using a qualitative multi-case study design (Stake, 1995), two Midwestern schools …

Reclaiming My Story: A Freirean Framework For Surviving Trauma And Transforming Recovery Into Liberation, Carl Bryan

The Interactive Journal of Global Leadership and Learning

This white paper explores trauma recovery through the lens of Paulo Freire’s Pedagogy of the Oppressed (1970/2018), framing healing as an act of critical consciousness and liberation rather than passive survival. Using the author’s lived experience of stalking, manipulation, and emotional abuse as a case study, it reimagines recovery not as a return to normalcy but as a dialectical process of reclaiming narrative agency, reconstructing identity, and transforming pain into purpose. Drawing upon Freirean concepts of conscientização (critical consciousness), dialogue, and praxis, the paper outlines a model for survivors to move from internalized oppression toward empowerment and social transformation.

Voices From The Hyflex Classroom: Understanding The Graduate Counseling Student Experience, Taryn Akgul, Jessica Brown, Aaron Suomala Folkerds

The Interactive Journal of Global Leadership and Learning

Counselor education and counseling master’s Programs face a changing landscape in higher education. This includes balancing the demand for a high-quality HyFlex program that prepares students for the counseling field. This qualitative exploratory study utilized a phenomenological approach to understand the counseling master's student experience in a hybrid program. The research questions focused on the students' experience attending the program either strictly on zoom, in person, or a combination of both and how that impacted them and their learning. The study consisted of eight participants who were alumni from one CACREP accredited counseling masters program. The findings included themes of …

Chemistry + Libraries -> Better Learning, Ashley S. Mcguire, Ellen A. Humphries, Ash B C Curtiss

Libraries Professional Work

The American Chemical Society (ACS) guidelines for chemical literacy, in undergraduate programs, are in three critical areas: information retrieval, information evaluation, and information management. As part of an ACS certified degree (1) students receive instruction in effective methods for performing and assessing the quality of searches using keywords, authors, abstracts, citations, patents, and structures/substructures; (2) students can use chemical identifiers to locate physical and chemical properties in handbooks and databases; and (3) students are assessed in their ability to conduct effective searches by reading, analyzing, interpreting, and citing the chemical literature as applied to answering chemical questions. There is an …

Broad Laboratory Testing Does Not Show Utility For Telogen Effluvium: A Retrospective Analysis Of 22-Million Laboratory Results Using Trinetx, Zachary J.K. Neubauer, Shari R. Lipner

Student Papers, Posters & Projects

No abstract provided.

Effect Of Remineralization And Resin Infiltration On Microhardness, Mineral Content And Cervical Microleakage Of Restored Demineralized Enamel, Sara Adel Botros, Caroline Maged Massieh

Dentistry

No abstract provided.

Technology-Enabled Cognitive Behavioral Therapy For Insomnia (Cbt-I) In Older Adults With Mild Cognitive Impairment: Development And Feasibility Study, Hongtu Chen, Marta Pagán-Ortiz, Sara Romero Vincente, Emma Chapman, James Maxwell, Otis L. Owens, Sue E. Levkoff Scd, Msw, Sm

Faculty and Staff Publications

Background/Objectives: Mild Cognitive Impairment (MCI) is a transitional stage between normal aging and early dementia, affecting up to 20% of older adults. Sleep disturbances, particularly insomnia, affect around 60% of individuals with MCI, contributing to declines in cognitive and physical function. Although Cognitive Behavioral Therapy for Insomnia (CBT-I) is an evidence-based non-pharmacological treatment, few studies have adapted it for individuals with MCI. This pilot study developed and evaluated Slumber, a clinician-supported mobile CBT-I app tailored for older adults with MCI and insomnia. Methods: The study had three aims: (1) to develop the app for delivering CBT-I to individuals with …

Real-World Data Investigating The Frequency Of Flash Glucose Monitoring And Glycaemic Metrics In Omani Diabetes Patients: A Preliminary Retrospective Cross-Sectional Study, Ammar Al-Mamari, Sumaia Al Gharabi, Merah Al Busaidy, Abdulla Al Futaisi

Sultan Qaboos University Medical Journal

Objectives: This study aimed to evaluate real-world glycaemic outcomes associated with flash glucose monitoring (FGM) use in patients with diabetes at Sultan Qaboos University Hospital, Muscat, Oman. Methods: This retrospective cross-sectional study was conducted among diabetic patients using flash glucose monitoring between January 2022 and August 2023. Patients were grouped by scanning frequency, time-in-range (TIR) and estimated A1c (eA1c). Associations between scanning frequency and glycaemic metrics were analysed. Results: A total of 436 patients were included in this study. Patients with higher scanning frequency (≥12 scans/day, median = 17) achieved greater TIR (52.4% versus 34.8%), lower time-above-range (41.8% versus 57.0%), …

Biochar To Improve The Thermal Performance Of Living Wall Systems: Laboratory Assessment Of Three Planting Substrates, Joao Alencastro, Thomas Murphy, Jack Morewood, Steve Goodhew

School of Art, Design and Architecture

Living wall systems (LWSs) help to alleviate the climate and biodiversity harms associated with buildings and bring benefits to building occupants. Their performance can be variable and existing research points to the planting substrate as a key design factor. This study provides quantitative evidence on the physical, thermal and moisture performance of three planting substrates that vary according to the proportion of biochar added to green waste compost (GWC). Thermal conductivity (Wm−1 K−1), thermal resistivity (mK W−1), volumetric moisture content (%) and mass (g) are measured for each fraction, replicated six times. Controlled drying procedures were employed, measuring these properties …

Financial Ratios And Stock Volatility: Empirical Evidence From The Banking Sector, Rahma Tri Benita

Journal of Accounting Auditing and Business

Banking stock price volatility is closely related to company performance and fundamental indicators. This study analyzes the short-term and long-term relationships between financial ratios and stock price volatility in the banking sector. Based on the results of the long-term correlation, the Price to Earnings Ratio (P/E) and Dividend Yield (DY) variables are proven to be dominant factors influencing volatility because they are directly related to stock price movements. In the short-term correlation between state-owned banks, there is an inverse relationship between Price to Book and ROE, and Debt to Equity has a significant negative effect on Return on Assets and …

Large-Scale Blood Pressure Gwas Accounting For Gene-Depression Interactions In 564,680 Individuals From Diverse Populations, Songmi Lee, Clint L Miller, Amy R Bentley, Michael R Brown, Pavithra Nagarajan, Raymond Noordam, John L Morrison, Karen Schwander, Kenneth Westerman, Minjung Kho, Aldi T Kraja, Paul S De Vries, Farah Ammous, Hughes Aschard, Traci M Bartz, Anh Do, Charles T Dupont, Mary F Feitosa, Valborg Gudmundsdottir, Xiuqing Guo, Sarah E Harris, Keiko Hikino, Zhijie Huang, Christophe Lefevre, Leo-Pekka Lyytikäinen, Yuri Milaneschi, Giuseppe Giovanni Nardone, Aurora Santin, Helena Schmidt, Botong Shen, Tamar Sofer, Quan Sun, Ye An Tan, Jingxian Tang, Sébastien Thériault, Peter J Van Der Most, Erin B Ware, Stefan Weiss, Wang Ya Xing, Chenglong Yu, Wei Zhao, Md Abu Yusuf Ansari, Pramod Anugu, John R Attia, Lydia A Bazzano, Joshua C Bis, Max Breyer, Brian Cade, Guanjie Chen, Stacey Collins, Janie Corley, Gail Davies, Marcus Dörr, Jiawen Du, Todd L Edwards, Tariq Faquih, Jessica D Faul, Alison E Fohner, Amanda M Fretts, Srushti Gangireddy, Adam Gepner, Mariaelisa Graff, Edith Hofer, Georg Homuth, Michelle M Hood, Xu Jie, Mika Kähönen, Sharon L R Kardia, Carrie A Karvonen-Gutierrez, Lenore J Launer, Daniel Levy, Maitreiyi Maheshwari, Lisa W Martin, Koichi Matsuda, John J Mcneil, Ilja M Nolte, Tomo Okochi, Laura M Raffield, Olli T Raitakari, Lorenz Risch, Martin Risch, Ana Diez Roux, Edward A Ruiz-Narvaez, Tom C Russ, Takeo Saito, Pamela J Schreiner, Rodney J Scott, James Shikany, Jennifer A Smith, Harold Snieder, Beatrice Spedicati, E Shyong Tai, Adele M Taylor, Kent D Taylor, Paola Tesolin, Rob M Van Dam, Rujia Wang, Wei Wenbin, Tian Xie, Jie Yao, Kristin L Young, Ruiyuan Zhang, Alan B Zonderman, Biobank Japan Project, Lifelines Cohort Study, Maria Pina Concas, David Conen, Simon R Cox, Michele K Evans, Ervin R Fox, Lisa De Las Fuentes, Ayush Giri, Giorgia Girotto, Hans J Grabe, Charles Gu, Vilmundur Gudnason, Sioban D Harlow, Elizabeth Holliday, Jonas B Jost, Paul Lacaze, Seunggeun Lee, Terho Lehtimäki, Changwei Li, Ching-Ti Liu, Alanna C Morrison, Kari E North, Brenda W J H Penninx, Patricia A Peyser, Michael M Province, Bruce M Psaty, Susan Redline, Frits R Rosendaal, Charles N Rotimi, Jerome I Rotter, Reinhold Schmidt, Xueling Sim, Chikashi Terao, David R Weir, Xiaofeng Zhu, Nora Franceschini, Jeffrey R O'Connell, Cashell E Jaquish, Heming Wang, Alisa Manning, Patricia B Munroe, Dabeeru C Rao, Han Chen, W James Gauderman, Laura J Bierut, Thomas W Winkler, Myriam Fornage

Faculty, Staff and Student Publications

Gene-environment interactions may enhance our understanding of blood pressure (BP) biology. We conducted a meta-analysis of multi-population genome-wide association studies (GWASs) of BP traits accounting for gene-depressive symptomatology (DEPR) interactions. Our study included 564,680 adults from 67 cohorts and four population backgrounds: African (5%), Asian (7%), European (85%), and Hispanic (3%). We discovered seven previously unreported BP loci showing gene-DEPR interaction. These loci mapped to genes implicated in neurogenesis (TGFA and CASP3), lipid metabolism (ACSL1), neuronal apoptosis (CASP3), and synaptic activity (CNTN6 and DBI). We also showed evidence for gene-DEPR interaction at nine known BP loci, further suggesting links between …

Proton Versus Photon Radiotherapy For Patients With Oropharyngeal Cancer In The Usa: A Multicentre, Randomised, Open-Label, Non-Inferiority Phase 3 Trial, Steven J Frank, Paul M Busse, J Jack Lee, David I Rosenthal, Mike Hernandez, David M Swanson, Adam S Garden, G Brandon Gunn, Samir H Patel, James W Snider, Daniel J Ma, Jason K Molitoris, Nancy Y Lee, Upendra Parvathaneni, Mark W Mcdonald, Noah S Kalman, Alexander Lin, Nasiruddin Mohammed, Christina Henson, Christian Hyde, Gopal K Bajaj, Sanford R Katz, Roi Dagan, William H Morrison, Jay P Reddy, C David Fuller, Shalin J Shah, Jack Phan, Gregory M Chronowski, Lauren Mayo, Erich M Sturgis, Renata Ferrarotto, Xiaorong R Zhu, Xiaodong Zhang, Li Wang, Katherine A Hutcheson, Adel K El-Naggar, Amy C Moreno, Anna Lee, Michael T Spiotto, Neil D Gross, Stephen Y Lai, Jay J Liao, Jonathan Paly, Zhongxing Liao, Robert L Foote

Faculty, Staff and Student Publications

Background: Radiotherapy is an integral component of treatment for oropharyngeal cancer. Toxicity from the current state-of-the-art photon radiotherapy, intensity-modulated radiation therapy (IMRT), has prompted the search for alternative, less toxic therapies. One such alternative that might de-intensify treatment is proton therapy. In this trial, we aimed to directly compare IMRT with intensity-modulated proton therapy (IMPT), both concurrent with systemic therapy, hypothesising comparable disease control and survival and lower toxicity.

Methods: This randomised, multicentre, open-label, non-inferiority, phase 3 trial was conducted in 21 sites (cancer centres or universities) in the USA. Patients (aged ≥18 years) with stage III or stage IV …

Association Of Neighborhood Economic Trajectories And Risk Of Mortality Among Older Adults, Erika Figueroa-Solis, Qian Xiao

Faculty, Staff and Student Publications

Background

Lower neighborhood socioeconomic status (SES) and decline in neighborhood SES have been linked to detrimental health outcomes, such as cardiovascular disease (CVD), cancer, and mortality. However, few studies have investigated distinct types of neighborhood economic trajectories in relation to mortality. We examined the association between the recently developed multidimensional measure of neighborhood trajectories and mortality in older adults enrolled in the National Institutes of Health-AARP Diet and Health Study (NIH-AARP).

Methods

Neighborhoods were classified into five groups based on economic change patterns from 2000 to 2016 using American Community Survey data: Stability, Growth, Displacement, Abandonment, and Poverty Concentration. Mortality …

Characteristics And Effectiveness Of Maternal Health Interventions To Prevent Mother-To-Child Transmission (Pmtct) Of Syphilis In A Global Setting: A Scoping Review Using Intervention Mapping As A Framework, Jinni Tang, Anusha Sajja, Christine Markham, Emily T Hebert, Irene Stafford, Sheryl Dacso, Melissa F Peskin

Faculty, Staff and Student Publications

Background: Despite the availability of cost-effective treatments, maternal syphilis continues to contribute significantly to preventable stillbirths and congenital syphilis cases worldwide. This scoping review aimed to identify and characterize maternal health interventions designed to prevent mother-to-child transmission (PMTCT) of syphilis globally, using a modified Intervention Mapping (IM) framework.

Methods: We conducted a scoping review of maternal health interventions targeting PMTCT of syphilis published between January 2010 and August 2023. Searches were performed in PubMed, Medline Ovid, and Embase, supplemented by manual reference screening. Eligible studies described at least one maternal health intervention addressing syphilis PMTCT and were analyzed using a …

Flipi24: A Modern Prognostic Model And Clinical Trial Enrichment Tool For Newly Diagnosed Follicular Lymphoma, Matthew J Maurer, Vit K Prochazka, Tarec Christoffer El-Galaly, Christopher R Flowers, Diego Villa, Emmanuel Bachy, Elliot J Cahn, Marguerite Fournier, Melissa C Larson, Caroline E Dietrich, Lasse Hjort Jakobsen, Hervé Ghesquières, Robert Kridel, Maher K Gandhi, Chan Y Cheah, Eliza A Hawkes, John F Seymour, Ciara L Freeman, Michael R Clausen, Björn E Wahlin, Jonathan W Friedberg, Carla Casulo, Thomas M Habermann, Yucai Wang, Loretta J Nastoupil, Peter De Nully Brown, David Belada, Andrea Janíková, Heidi Mocikova, Tomáš Fürst, Pierre Feugier, Hervé Tilly, Corinne Haioun, Andrew J Davies, Guillaume Cartron, Richard Burack, Dai Chihara, Peter Martin, Jonathon B Cohen, Izidore S Lossos, Brad S Kahl, Laurie H Sehn, Karin E Smedby, Gilles Salles, Marek Trneny, Brian K Link, Franck Morschhauser, James R Cerhan

Faculty, Staff and Student Publications

Purpose: Although most patients with follicular lymphoma (FL) can expect an indolent course, progressive lymphoma remains the primary cause of death during the first decade after diagnosis. Progression of disease within 24 months (POD24) of starting first-line (1L) immunochemotherapy defines a high-risk population with poor survival, but better risk stratification at diagnosis is needed.

Methods: The FLIPI24 model was developed and internally validated to predict 24-month event rates using individual data from 4,485 patients treated with 1L immunochemotherapy from 10 observational cohorts of FL. Overall and cause-specific survival was further evaluated in FLIPI24 risk groups. External validation in the 1L …

Comparing Power Outputs Of A Jump Shrug With A Hex Bar Vs A Straight Bar, Joshua Neumann

Doctorate in Kinesiology

The purpose of this dissertation was to examine whether barbell selection influenced power outputs during loaded jump shrugs in collegiate athletes and to connect research findings to practical applications in strength and conditioning. Although Trap Bars are often assumed to provide mechanical advantages during explosive lifts, limited research has evaluated their impact during ballistic derivatives such as jump shrugs. This study addressed that gap by comparing the performance of Straight Bar and Trap Bar exercises across four standardized loads in male and female Division II athletes. A repeated-measures design was used to assess barbell velocity, concentric mean power, peak landing …

Identification Of Cadm1 As An Immunotherapeutic Target And Evaluation Of A Novel Cadm1-Targeting Antibody-Drug Conjugate In Preclinical Osteosarcoma Models, Yifei Wang, Zhongting Zhang, Caterina Longo, Wendong Zhang, Qi Wang, Amer Najjar, Xiangjun Tian, Rossana N Lazcano Segura, Michael E Roth, Jonathan Gill, Douglas J Harrison, Zhaohui Xu, Yanhua Yi, Xin Zhou, Sylvester Jusu, Timothy M Stearns, Steven B Neuhauser, Carol J Bult, Jing Wang, Alexander J Lazar, Richard Gorlick

Faculty, Staff and Student Publications

Due to the paucity of validated cell surface osteosarcoma-specific targets, patients with this condition have long been excluded from the benefits of antibody-drug conjugate (ADC) therapy observed in patients with several solid and hematologic malignancies. Our comprehensive surfaceome profiling approach previously identified osteosarcoma-specific cell-surface antigens that are highly expressed in osteosarcomas but minimally expressed in normal tissues. As a result, one such antigen, CADM1, was selected for the generation of an ADC. We tested a CADM1-targeting ADC with a tesirine payload (SG3249) in vitro in osteosarcoma, rhabdomyosarcoma, and neuroblastoma patient-derived xenograft cell lines. In vivo, we tested six CADM1-expressing osteosarcoma …

Unravelling Impact Of Comorbidities On Mortality Risks In Ckd Patients During The Covid-19 Pandemic: An Explainable Ai-Driven Study, Zeinab Abdollahi, Lin Huo, Donald Fraser, Shang-Ming Zhou

School of Nursing and Midwifery

ObjectivesThe chronic kidney disease (CKD) patients were at high risk for severe clinical complications during the COVID-19 pandemic. Our objectives were to evaluate comorbidity prevalence; predict mortality risks for CKD patients during the pandemic; assess how various health factors interact to influence mortality; and provide insights for targeted prevention strategies.MethodWe analysed data from 186,396 CKD patients in Mexico during the entire pandemic (Jan 2020- May 2023). Explainable artificial intelligence (XAI) methods with extreme gradient boosting (XGBoost) models and Shapley Additive Explanations (SHAP) were developed to predict mortality for CKD patients with model interpretations. Different metrics were used to comprehensively evaluate …

Multipath Exploitation For Radar Sensing In An Urban Environment Using The Music Algorithm For Jammer Mitigation, Daniel De Zutter

Theses

With the increased push for spectrum sharing techniques, the technological world surrounding radar has been constantly pushing to find new methodologies. From being able to integrate with a communication system to mitigating the effects of other users on a system, the research community is pushing forward. We look to tackle the problem of mitigating a jammer using a multipath MUltiple SIgnal Classification (MUSIC) based approach. We take multiple steps to implement this and generate a framework for future work. We first take a look at understanding the current state of the art research surrounding DFRC, multipath exploitation, MUSIC algorithms, RIS …

The Computationally Designed Tri2-2 Miniprotein Inhibitor Protects Against Multiple Sars-Cov-2 Omicron Variants, Jimin Lee, James Brett Case, Young-Jun Park, Rashmi Ravichandran, Daniel Asarnow, M Alejandra Tortorici, Jack T Brown, Shilpa Sanapala, Lauren Carter, David Baker, Michael S Diamond, David Veesler

2020-Current year OA Pubs

The continued evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has compromised neutralizing antibody responses elicited by prior infection or vaccination and abolished the utility of most monoclonal antibody therapeutics. We previously described a computationally-designed, homotrimeric miniprotein inhibitor, designated TRI2-2, that protects mice against pre-Omicron SARS-CoV-2 variants. Here, we show that TRI2-2 exhibits broadly neutralizing activity of SARS-CoV-2 variants and protects mice against BQ.1.1, XBB.1.5 and BA.2.86 challenge when administered intranasally post-exposure. The resistance of TRI2-2 to viral escape by most variants and the ability to deliver it directly to the upper airways highlight the potential of the multivalent …

An Optimized Hybrid Xgboost-Lstm-Gru Model For Energy Consumption Forecasting In Smart Homes Using Weather Data, Marwah J. Salman, Eman M. El-Gendy, Amira Y. Haikal, Mahmoud M. Saafan

Mansoura Engineering Journal

Energy consumption is increasing every day due to the proliferation of smart homes and smart household appliances, which deplete existing energy resources. Therefore, efficient energy management by accurately predicting energy consumption is critical. In this paper, a hybrid prediction model is proposed to forecast energy consumption in smart homes using weather data. The proposed system follows five steps: data acquisition, data preprocessing, feature selection, prediction, and hyperparameter optimization. In the data acquisition step, all attributes except the weather attributes are removed. The min-max algorithm is then applied to normalize the dataset to a specific scale, preventing the prediction model from …

Fragmented Foundations: Interpreter Educator Resources And Uneven Student Preparation, Kierstin S. Muroski

Journal of Interpretation

The readiness-to-work gap among graduates of signed language interpreting programs has been widely acknowledged for decades. Efforts to address the gap have primarily focused on training methods and student performance. This paper shifts the focus to interpreter educators, examining whether the inconsistencies in their awareness and use of discipline-related books may contribute to the disparate educational outcomes of students entering the workforce. Drawing on survey data from 75 interpreter educators in the United States, this study explores demographic patterns of their book awareness and usage in teaching. Results indicate that awareness and utilization of discipline-related books to support teaching are …