Digital Commons Network^™

Redefining The Role Of Chaperones For Dot/Icm T4bss-Mediated Substrate Translocation By Legionella Pneumophila, Sukhithasri Vijayrajratnam, Ahmet Hasanovic, Joseph P Vogel

2020-Current year OA Pubs

Legionella pneumophila, the etiological agent of legionnaires' disease, establishes its intracellular niche through the Dot/Icm type IVB secretion system, which translocates ∼300 effector proteins into host cells. Efficient secretion of many effectors requires the IcmS and IcmW chaperones, which interact with both substrates and the type IV coupling protein DotL. A prior model proposed that IcmSW are released from substrates during translocation by transfer to the C terminus of DotL and then recycled to the cytoplasm. This model predicts an excess cytoplasmic pool of IcmSW and their dissociation from DotL. We tested these predictions using quantitative stoichiometric analysis of Dot/Icm …

Myd88 Signaling In Myeloid Cells Induces Gastrointestinal Tract Injury And Systemic Inflammation After West Nile Virus Infection, Shih-Ching Lin, Fang R Zhao, Matthias Mack, Gabriel Mbalaviele, Michael S Diamond

2020-Current year OA Pubs

Humans with autoantibodies to type I interferons (IFNs) are at higher risk for neurological disease after West Nile virus (WNV) infection. IFN signaling deficient WNV-infected mice develop greater inflammation in the brain, which correlates with loss of gut barrier integrity. Here, we investigate the immune pathways that mediate this virus-gut-brain axis of inflammation. Myd88

Dual Roles Of Trpv2 In The Innate Immune Response To Cytosolic Dna: Arresting Dormant And Boosting Activated Sting, Chen Cheng, Hsiang-Ting Lu, Shan Li, Zhongsheng You

2020-Current year OA Pubs

The cGAS/STING-dependent innate immune pathway is central in the cellular response to cytosolic DNA derived from viral infections, genotoxic stress, or mitochondrial defects. While efficient activation of the pathway is crucial for defending against pathogens and cancer, maintaining its dormancy without stimuli is equally important to avoid autoimmunity. However, the precise control of the cGAS/STING pathway remains poorly understood. Here, we report that the ion channel TRPV2 regulates both the dormancy and activation of STING. TRPV2 associates with STING and suppresses spontaneous STING activation in the absence of cytoDNA but dissociates from STING and promotes its activation by releasing Ca

Distinct Contributions Of Etv2+ And Flk1+ Progenitors To Endothelial, Hematopoietic, And Cardiac Lineages, Dereck Alleyne, Minseo Kim, Jun Wu, Yoojung Kwon, Ye-Ram Kim, Ashraf Ul Kabir, Matthew Ishahak, Jeffrey R Millman, Changxu Fan, Hyung Joo Lee, Karen Krchma, Xiaoyun Xing, Kory Lavine, Ting Wang, Kyunghee Choi

2020-Current year OA Pubs

The ETS family transcription factor ETV2, VEGFA, and its receptor FLK1 are essential for hematopoietic, vascular, and cardiac development. Here, we combine dual Etv2 and Flk1 lineage tracing with molecular profiling to define how mesoderm progenitors are allocated to hematopoietic, endothelial, cardiomyocyte, and smooth muscle lineages. We demonstrate that hematopoietic, endothelial, and cardiac valves arise from dual Etv2

Ablation Of Cd38 In Multiple Myeloma Cells Leads To An Aggressive Phenotype In A Mouse Xenograft Model, Michael R Dyer, Alex Zheleznyak, Erin N Teubner, Julie L Prior, Brad Manion, Zhenghan Jing, Amit K Sharma, Junwei Du, Rui Tang, Mark A Fiala, John F Dipersio, Deborah Veis, Julie O'Neal, Mikhail Y Berezin, Monica Shokeen

2020-Current year OA Pubs

Multiple myeloma (MM) is a plasma cell malignancy characterized by bone pain and end-organ failure. A major challenge in treating MM is therapeutic resistance. CD38-targeted immunotherapies, such as daratumumab, have significantly improved outcomes; however, variable responses, resistance, and relapse remain vital challenges. We hypothesized that loss of CD38 drives a more aggressive phenotype and resistance to therapy. To test this, we developed a CD38 knockout (KO) clone of a human MM cell line and evaluated it in immunodeficient mice. Mice with CD38 KO tumors exhibited an increased tumor burden and reduced survival compared with those with CD38 wild-type (WT) tumors. …

Inducible Deletion Of Dgat1 And 2 From Microglia Exacerbates Neurodegeneration And Endolysosomal Lipid Accumulation In Male Ps19 Mice, G Travis Tabor, Alexandra Litvinchuk, Yun Chen, Austin Allison, Carisa Zeng, Hao Hu, Peter B Lin, Prabal Sharma, Samira Parhizkar, Sihui Song, Xin Bao, Abhirami K Iyer, Shih Feng You, Javier Remolina Serrano, Melissa Manis, Emily Franke, Anil G Cashikar, Carla M Yuede, Celeste M Karch, Eric J Huang, Maxim Artyomov, Jason D Ulrich, David M Holtzman, Et Al.

2020-Current year OA Pubs

Brain myeloid cells accumulate neutral lipids in multiple human neurodegenerative disorders and relevant mouse models. These lipids are often assumed to be contained in lipid droplets (LDs). While studies have been performed in cell culture and Drosophila models to characterize glial LDs, the roles of microglial LD biogenesis in mammalian tauopathy are unclear. To address this issue, we induced the deletion of diacylglycerol acyltransferases (DGATs) 1 and 2, enzymes critical for LD formation, from microglia in the PS19 mouse model of tauopathy. Microglial DGAT double knockout (KO) exacerbated neurodegeneration and increased the abundance of brain cholesteryl esters in male PS19 …

Expression Spectrum Of Te-Driven Transcripts In Human Adult Tissues, Benpeng Miao, Xinlong Luo, Amina Ademovic, Yushan Yang, Tao P Wu, Bo A Zhang

2020-Current year OA Pubs

BACKGROUND: Transposable elements (TEs) are vital components of eukaryotic genomes and have played a critical role in genome evolution. Although most TEs are silenced in the mammalian genome, increasing evidence suggests that certain TEs are actively involved in gene regulation during early developmental stages. However, the extent to which human TEs drive gene transcription in adult tissues remains largely unexplored. RESULTS: In this study, we systematically analyze 17,329 human transcriptomes to investigate how TEs influence gene transcription across 47 adult tissues. Our findings reveal that TE-driven transcripts are broadly expressed in human tissues, contributing to both housekeeping functions and tissue-specific …

Place Identity Of Korean Restaurants In Bandung, Indonesia, Aida Faiz Mutiara Sari, Hayuning Anggrahita, Alif Raya Zulkarnaen, Guswandi Guswandi

Jurnal Geografi Lingkungan Tropik (Journal of Geography of Tropical Environments)

Place identity is a perception that comes from social actors who have knowledge, interest, or authority in that place. Moreover, it refers to the relationship between space and its identity. It emphasizes its meaning and significance for individuals that experience it. Korean restaurant In Bandung-Indonesia is a culinary or food business that combines South Korean culture as an attraction that can become the identity of the place. Bandung Wetan Sub-District in Bandung City, Indonesia, is chosen as the case study location to determine the place identity of Korean restaurants. This study aims to determine the place identity of Korean restaurants …

Educational Design Models In Transition: A Comparative Review, Tofan Stofiana, Yeti Mulyati, Andoyo Sastromihardjo, Dadang Sunendar

Journal of Educational Research and Practice

A persistent gap between educational theory and classroom practice underscores the need for methodological approaches that are reflective, participatory, and context responsive. This study provides a comparative review of four major educational design models, including research and development (R&D); Analysis, Design, Development, Implementation, and Evaluation (ADDIE); design-based research (DBR); and educational design research (EDR), to examine their theoretical orientations and contemporary applications. A systematic literature synthesis and bibliometric mapping were conducted on 80 peer-reviewed journal articles indexed in Scopus between 2020 and 2025. The findings reveal that ADDIE remains the most frequently applied framework due to its procedural clarity and …

Factor And Demand Conditions Shaping Production Effectiveness In Remote Msmes: A Case Study Of Luci Snack In North Kalimantan, Saadiq Alhadi, Hasyim Asyari

Jurnal Vokasi Indonesia

The production effectiveness of agro-industrial MSMEs in remote frontier regions is severely hampered by geographic isolation and lack of basic infrastructure. This study examines the unique case of Luci Snack in North Kalimantan, operating without state electricity or land access. The research aims to analyze how the interaction between Factor Conditions (river logistics and technology) and Demand Conditions influences Production Effectiveness. Employing an embedded single-case study design, data were collected via in-depth interviews with the owner and village officials, participant observation, and documentation, then analyzed using the Miles, Huberman, and Saldaña (2014) interactive model. Findings reveal a paradox: (1) Production …

Analysis Of The Effect Of Neuro-Developmental Treatment (Ndt) On Gross Motor Function In Children With Spastic Diplegic Cerebral Palsy: A Systematic Review, Haunan Naja Izdihar, Aditya Denny Pratama

Jurnal Vokasi Indonesia

Effectiveness of Neurodevelopmental Treatment (NDT) in Children with Spastic Diplegia Cerebral Palsy: A Systematic Review

Background:
Neurodevelopmental Treatment (NDT) is commonly used in pediatric rehabilitation to improve motor function in children with cerebral palsy, particularly those with spastic diplegia.

Methods:
This systematic review followed PRISMA 2020 guidelines. Seven studies published between 2018 and 2024 were identified through electronic databases, including PubMed, Scopus, ProQuest, ScienceDirect, SpringerLink, Cochrane Library, Google Scholar, and Crossref.

Results:
The included studies reported improvements in gross motor function, posture, balance, and daily functional independence following NDT, particularly when combined with other therapeutic interventions. However, outcome measures and …

A Cross-System Analysis Of Structural Commensurability Between Axiomatic Foundations Of Set Theory (Zfc) And The Principles Of Transcendent Wisdom, Mohammadjavad Maarefvand

Comparative Philosophy

Building on observed similarities in uniqueness proofs for the empty set and the Necessary Existent (Wājib al-Wujūd), this study engages the meta-methodological issue of cross-system commensurability. It identifies four instances of structural commensurability between Zermelo-Fraenkel set theory with Choice (ZFC) and Mulla Sadra's Transcendent Wisdom (Ḥikmat al-Muta'āliyah). First, identity principles: the Axiom of Extensionality provides a formal operational criterion analogous to the philosophical principle of identity through absence of distinguishing features. Second, multiplicity mechanisms: ZFC's constructor axioms (bottom-up construction) and emanation principles (top-down explanation) address analogous problems with inverse orientations. Third, transcending limitation: the Axiom of Infinity ensuring quantitative extensional …

A Critique Of Ziporyn’S Interpretation Of Early Chinese Thought: From The Constructive-Engagement Vantage Point, Xiaoqiao Liu

Comparative Philosophy

Sameness and difference are among the most fundamental and yet most tension-laden categories in philosophy, bearing directly on the conditions under which judgment, classification, and meaning become possible. This article critically reconstructs and compares two influential but methodologically divergent approaches to this issue in contemporary comparative philosophy. One is Brook Ziporyn’s idea of coherence, which seeks to articulate a non-substantialist metaphysics as a response to tensions internal to the Western metaphysical tradition. The other is Bo Mou’s enhanced account of relative identity, which revises both absolute and modern relative identity theories through a bottom-up, semantically grounded framework oriented toward cross-tradition …

Father Knows Best? Not Here: Metaphors Of Kinship And Kingship In Haudenosaunee, Aristotelian, And Confucian Political Thought, Ian Kalman

Comparative Philosophy

The notion that the organization of large-scale social structures are rooted in domestic ones has a longstanding history in both Chinese and Greek classical political philosophy. Aristotle and Confucius independently reasoned that a good family, one with a strong father, mapped onto a good state, one with a strong king - though they differed on the details. While there is a strong literature juxtaposing these two titans, less attention has been paid to how their ideas compare with other philosophical traditions. This article provides an anthropological intervention to the comparative study of Confucius and Aristotle – while both autonomously argued …

The Coherence Of Navayāna Pragmatism: Ambedkar And The Pragmatist Reconstruction Of Buddhist Philosophy, Danish Hamid

Comparative Philosophy

This paper examines the philosophical coherence of B.R. Ambedkar’s reconstruction of his (Navayāna) Buddhism in relation to John Dewey’s pragmatism. Building on Scott Stroud’s reading of Ambedkar as a Deweyan Pragmatist (2017, 2023), it argues that Dewey’s evolutionary naturalism, his conception of growth, and pragmatic redefinition of concepts provide Ambedkar with the methodological tools for a naturalistic and socially reconstructive reinterpretation of Buddhist doctrines such as anicca (impermanence), dhamma (Buddha’s teaching), nirvāṇa (enlightenment), karuna (compassion), etc. Ambedkar transforms impermanence from a metaphysics of flux into an ethics of progressive growth, and recasts dhamma as a social morality grounded in fraternity …

Challenging The Double-Negation Principle: An Analysis Of Strategic Theories Of Sun Zi, Carnot, And Clausewitz Through Intuitionist Logic, Antonino Drago

Comparative Philosophy

To study a subject similarly represented in Eastern and Western cultures, I examine some classical theories of war strategy according to a new analytical method. This method is based on the recognition that the most important strategic theories are organized as theories essentially not deduced from axioms according to classical logic. Such theories reason through doubly negated propositions (DNPs), whose meanings differ from those of their affirmative counterparts. This corresponds to the use of intuitionist logic instead of classical logic. An inspection of the works of the texts of Sun Zi, Lazare Carnot, and Clausewitz reveals many such propositions, and …

Vol 17 No 1 Information Page

Comparative Philosophy

No abstract provided.

Cape Cod Ocean Watch, Finn Wimberly, Svenja Ryan, Aubrey Ellertson Church, Melissa Sanderson, George Maynard, Linus Stoltz

Benefits of Ocean Observing Catalog (BOOC)

The Cape Cod Ocean Watch dashboard is an interactive, map-based data visualization platform that delivers near real-time information on coastal ocean conditions across the Northeast U.S. shelf. The dashboard integrates hydrographic profiles collected by commercial fishermen with remotely-sensed surface datasets, bottom-condition products from eMOLT and FIShBOT, and short-term forecasts from the Doppio regional ocean model. These datasets are synthesized into a single, user-friendly interface designed to support the information needs of the fishing community. We aim to provide an integrated platform which transforms diverse oceanographic datasets into actionable insights, strengthens communication between members of the fishing community and scientists, and …

Procedure To Evaluate Artificial Intelligence (Ai) Output For Educational And Clinical Tasks, Lynn Gilbertson, Cody Marie Busch, Jon Spike, Kaitlin Demoss, Jae Thompson

Teaching and Learning in Communication Sciences & Disorders

As generative artificial intelligence (AI) becomes more ubiquitous and accessible, there is a call to promote awareness, implementation, and evaluation skills among AI users. Free AI platforms offer unprecedented opportunities to transform how education and healthcare tasks are approached. However, a process for evaluating AI output has yet to be standardized. The current study implemented a structured process for guiding graduate and undergraduate students through critical evaluations of various AI platforms, promoting students' critical thinking and career readiness.

Assessing Learning In Simulation Learning Experiences In Graduate Programs For Speech-Language Pathology: A Phenomenological Study, Robyn Walker, Casey Ozaki

Teaching and Learning in Communication Sciences & Disorders

The purpose of this study was to use qualitative inquiry to explore how faculty assess student learning in clinical simulation-based learning experiences (SBLEs) used to demonstrate clinical competence in graduate programs in Communication Sciences and Disorders: Speech-Language Pathology (CSD). The following research questions were addressed: How do faculty experience the assessment of learning in SBLE? In what ways do faculty assess student learning in SBLE specifically designed to meet clinical competency standards? What, if any, effect has the COVID-19 pandemic had on the use of SBLE and assessment of student learning used to address clinical competency standards? A total of …

Effects Of Infused Instruction On Graduate Students’ Knowledge, Self-Perceptions, And Misconceptions Of African American English Dialect, Virginia L. Dubasik, Tim Brackenbury, Jasmine I. Wilson

Teaching and Learning in Communication Sciences & Disorders

Despite guidelines and requirements for training programs in communication sciences and disorders (CSD), pre-service and practicing speech-language pathologists report feeling under-prepared to work with speakers of Nonmainstream American English (NMAE) dialects such as African American English (AAE; Latimer-Hearn, 2020). The current study explored explicit instruction of the phonological and syntactic characteristics of AAE via infused instruction with speech-language pathology graduate students. Participants were 43 first- and second-year students in a CSD program. At the start of the course, participants completed a pre-instruction survey containing questions regarding demographics, exposure/experiences with AAE, baseline knowledge of AAE characteristics, and misconceptions regarding the dialect. …

Review Of "Canada And The Korean War: Histories And Legacies Of A Cold War Conflict" Edited By Andrew Burtch And Tim Cook, Tod Strickland

Canadian Military History

Review of Canada and the Korean War: Histories and Legacies of a Cold War Conflict edited by Andrew Burtch and Tim Cook

Review Of "The Age Of The Gas Mask: How British Civilians Faced The Terrors Of Total War" By Susan R. Grayzel, Kyle Pritchard

Canadian Military History

Review of The Age of the Gas Mask: How British Civilians Faced the Terrors of Total War by Susan R. Grayzel

Interview With Natalia Rachel Singer

Creative Nonfiction Magazine

No abstract provided.

Interview With Mary Paumier Jones

Creative Nonfiction Magazine

No abstract provided.

Interview With Carolyn Kremers

Creative Nonfiction Magazine

No abstract provided.

Profile: John Mcphee, Michael Pearson

Creative Nonfiction Magazine

No abstract provided.

Profile: Susan Feldman

Creative Nonfiction Magazine

No abstract provided.

Pilgrims, Philip Garrison

Creative Nonfiction Magazine

No abstract provided.

How Tununak Came To Me, Carolyn Kremers

Creative Nonfiction Magazine

No abstract provided.