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Oral Health Service Of Older Adults In Long-Term Care Facilities, Puntawee Barameepipat Jan 2022

Oral Health Service Of Older Adults In Long-Term Care Facilities, Puntawee Barameepipat

Chulalongkorn University Theses and Dissertations (Chula ETD)

To assess oral health service in long-term care facilities in Bangkok Methods: A cross-sectional study was conducted in 50 licensed long-term care facilities in Bangkok. Informed consent was obtained from all participants before conducting phone interviews and administering the questionnaire. The questionnaire covered various aspects, including demographics, health services, and oral health services provided within the long-term care facilities. Results: The study revealed variations in terms of operational years, service capacity, service expense per month, and provision of health services, including oral health services. It was found that the differences in service expenses impacted the provision of denture care for …

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Intention To Obtain Silver Diamine Fluoride Treatment For Dental Caries Among Elderly, Ratchawipa Nakphu Jan 2022

Intention To Obtain Silver Diamine Fluoride Treatment For Dental Caries Among Elderly, Ratchawipa Nakphu

Chulalongkorn University Theses and Dissertations (Chula ETD)

Aims: To evaluate the intention of the elders to use the Silver Diamine Fluoride (SDF) treatment for stopping dental caries progression after being informed Materials and Methods: The elders aged 60-90 years old who are independent and can read Thai were recruited. A questionnaire-guided interview was performed to the elders after introduction of the SDF treatment. The questionnaire-guided interview was guided by the Theory of Reason Action (TRA) composed of 23 questions of 7 constructs including behavioral belief, evaluation of behavioral outcome, normative belief, motivation to comply, attitude towards behavior, subjective norm and intention. The intention to do the SDf …

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Cranio-Oro-Facial Features And Masticatory Function In Patients With Craniosynostosis, Yanisa Wongbanthit Jan 2022

Cranio-Oro-Facial Features And Masticatory Function In Patients With Craniosynostosis, Yanisa Wongbanthit

Chulalongkorn University Theses and Dissertations (Chula ETD)

Objectives: The aim of this study was to evaluate cranio-oro-facial features and masticatory function in Thai subjects with craniosynostosis. Methods: Thirteen craniosynostosis (CS) patients aged between 6 - 17 years old who had treatment at the Princess Sirindhorn Craniofacial (PSC) Center, King Chulalongkorn memorial hospital and thirty age-matched non-CS subjects were recruited. Inform consents were obtained. Medical records were retrieved. Craniofacial and oral examination, radiographic evaluation, photograph, and masticatory function were recorded and compared with data of control subjects and that of Thai norms. Results: Among thirteen CS patients, four cases had cleft palate (30.8%), five had anterior openbite (38.5%), …

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Factors Associated With Oral Health Status Among The Healthy Elderly In Phon Thong District, Roi Et Province, Thailand, Yaowapa Chantaraboot Jan 2022

Factors Associated With Oral Health Status Among The Healthy Elderly In Phon Thong District, Roi Et Province, Thailand, Yaowapa Chantaraboot

Chulalongkorn University Theses and Dissertations (Chula ETD)

Objective: This study aimed to identify factors related to the oral health status of healthy elderly people in Phon Thong District, Roi Et Province, Thailand. Materials and methods: This cross-sectional study was conducted between 1 May and 25 December 2020 in Phon Thong District, Roi Et Province. A total of 249 male and female elderly people participated in the study. Oral health information was collected by trained dental hygienists using the Thai version of the oral health assessment tool [OHAT]. Data analysis used Mann–Whitney U tests, Chi-Square tests, and Binary logistic regression. Results: There were statistically significant associations between oral …

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The Potential Risk And Occupational Exposure Of Pesticides Among Rice Farmers In Delta Ayeyarwady Division, Myanmar, Moe Thu Khin Jan 2022

The Potential Risk And Occupational Exposure Of Pesticides Among Rice Farmers In Delta Ayeyarwady Division, Myanmar, Moe Thu Khin

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study aims to assess the potential risk and occupational exposure of pesticides among rice farmers in the Delta Ayeyarwady Region, Myanmar. A cross-sectional study was carried out with 454 rice farmers from March-April 2022. Data collection was done through face-to-face interviews used with a semi-structured questionnaire. The study showed that the mean age of farmers was 44.36 years old while the range was 16 and 74 years old. Rice farmers' average weight (± standard deviation) was 56.86 (± 7.30) kg. In this study, over two-thirds of the rice farmers (77 %) had a moderate level of knowledge regarding environmental …

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Assessment Of Greenhouse Gases Emissions From Dairy Cattle Production In Thailand, Phoo Pwint Pwint Thu Jan 2022

Assessment Of Greenhouse Gases Emissions From Dairy Cattle Production In Thailand, Phoo Pwint Pwint Thu

Chulalongkorn University Theses and Dissertations (Chula ETD)

Thailand’s agriculture sector plays a vital role in driving economic growth. Globally, livestock production is estimated to contribute about 18% of greenhouse gas (GHG) emissions. Despite its importance, there is a relative lack of research on GHGs assessment in the livestock sector in Thailand. The aim of this research was to estimate GHGs emissions from dairy cattle production in Saraburi and Ratchaburi provinces of Thailand. The 2019 Refinement to the 2006 IPCC guidelines for national greenhouse gas inventories was applied in this research. Twenty dairy farms (n=20) including both small farms (n=10) and medium farms (n=10) were selected as the …

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Effectiveness Of 1- And 2- Per Cent Acetic Acid Solutions In The 2-Week Treatment Of Granular Myringitis, Sarun Prakairungthong Jan 2022

Effectiveness Of 1- And 2- Per Cent Acetic Acid Solutions In The 2-Week Treatment Of Granular Myringitis, Sarun Prakairungthong

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: Granular myringitis is characterized by de-epithelization of the tympanic membrane. Patients present with intermittent otorrhea, otalgia or itching. Granular myringitis could result in ear canal stenosis from fibrotic formation if improper or inadequate treatments were offered. At the present, there are still no standard specific topical ear drops for granular myringitis. The choices of treatment are various with inconsistent success rate in variable timeline. Objectives: To compare granular myringitis treatment between 1% and 2% acetic acid solution at 2 weeks Materials and methods: This study is a double blind randomized controlled trial to compare the effectiveness of 1% acetic …

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Optimizing Energy Efficiency Projects In Bangkok Large Commercial Buildings, Angelica Arisa Morgan Jan 2022

Optimizing Energy Efficiency Projects In Bangkok Large Commercial Buildings, Angelica Arisa Morgan

Chulalongkorn University Theses and Dissertations (Chula ETD)

As a significant contributor to greenhouse gas emissions in the Asia Pacific region, Thailand has pledged to lower its GHG emissions by 555 million tCO2e by the year 2030. In Bangkok, energy efficiency projects in the large commercial buildings sector are an integral method by which to reduce emissions and to support a lower carbon future. Besides carbon dioxide emissions, energy efficiency projects also have the potential for other benefits including electricity and cost savings. This study develops a methodology to quantify the emissions reduction, electricity savings, and cost savings potential of various energy efficiency methods in this sector, and …

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Forecasting Cane Sugar Production Under Climate Change And Human-Ecotoxicological Impact, Arisara Tachabunya Jan 2022

Forecasting Cane Sugar Production Under Climate Change And Human-Ecotoxicological Impact, Arisara Tachabunya

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study forecasted sugar cane yield and cane sugar production using stepwise multiple linear regression (MLR) and autoregressive integrated moving average (ARIMA). Then, impacts on human health and ecosystems at the endpoint level were evaluated using openLCA software version 1.10.3 and the ReCiPe 2016 method. The functional units were the production of 1 kg raw sugar, 1 kg granulated sugar, and 1 kg refined sugar at Tamaka Sugar Industry Co., Ltd., Kanchanaburi province, Thailand. The result revealed that relative humidity at the Thong Pha Phum meteorological station, maximum temperature at the Kanchanaburi meteorological station, and oceanic Niño Index (ONI) were …

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Influence Of Tidal Current On Microplastic Dynamics In Chao Phraya River Estuarine Ecosystem, Jiradet Tang-Siri Jan 2022

Influence Of Tidal Current On Microplastic Dynamics In Chao Phraya River Estuarine Ecosystem, Jiradet Tang-Siri

Chulalongkorn University Theses and Dissertations (Chula ETD)

Microplastics (MPs) can be found almost everywhere in marine ecosystems. That is one of the issues of concern around the world, including in Thailand. Estuary ecosystems are also among the most disturbed. By the estuary ecosystem affected by both rivers and oceans, such as the mouth of the Chao Phraya River in Thailand. Due to the change in tide, it is necessary to study the effects of tidal currents on the depth of MPs. Water samples were collected at approximately 60 water levels in 24 hours. Samples and three water quality indicators were collected at Pak Nam Chao Phraya. The …

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Wastewater-Based Epidemiology And Quantitative Microbial Risk Assessment Associated With Wastewater Contact Of Norovirus In Bangkok, Thailand, Nonnarit Sriporatana Jan 2022

Wastewater-Based Epidemiology And Quantitative Microbial Risk Assessment Associated With Wastewater Contact Of Norovirus In Bangkok, Thailand, Nonnarit Sriporatana

Chulalongkorn University Theses and Dissertations (Chula ETD)

Norovirus is one of the leading causes of acute gastroenteritis worldwide. Wastewater surveillance offer significant benefits such as enhancing our understanding of the disease occurrence in the population, evaluating the effectiveness of pathogen reduction in the treatment process, and tracking the spread of pathogens in the environment which pose a health risk to humans. Hence, wastewater surveillance is crucial. In this study, the influent and effluent samples were collected bi-monthly from March 2020 to March 2021 from three distinct wastewater treatment plants in Bangkok. Wastewater samples were concentrated and subjected to quantitative polymerase chain reaction (qPCR) to assess norovirus concentrations. …

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Southeast Asian Ministers Of Education Organization (Seameo) 'S Role In Digitalisation For Vocational Education Development : A Comparative Analysis Of Indonesia And Thailand, Anastasia Sylvia Jan 2022

Southeast Asian Ministers Of Education Organization (Seameo) 'S Role In Digitalisation For Vocational Education Development : A Comparative Analysis Of Indonesia And Thailand, Anastasia Sylvia

Chulalongkorn University Theses and Dissertations (Chula ETD)

This thesis focuses on the role of the SEAMEO (Southeast Asian Ministers of Education Organization) role in vocational education development in Industry 4.0. Nowadays, there is a demand for the education sector to align with Industry 4.0, known as Education 4.0. In 2018, the SEAMEO, in collaboration with the GIZ, launched a Regional In-Service Training Modules project to support vocational education for Education 4.0. This study compares the impact of the Regional In-Service Training Modules project in two countries with a medium level of education performance in Southeast Asia: Indonesia and Thailand. This study employs a qualitative method with a …

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Climate Imaginaries And Human Mobility: Complicating Climate Mobility As Adaptation In Thailand, Clare Steiner Jan 2022

Climate Imaginaries And Human Mobility: Complicating Climate Mobility As Adaptation In Thailand, Clare Steiner

Chulalongkorn University Theses and Dissertations (Chula ETD)

For centuries, agricultural households in Thailand have engaged in mobility to adapt to environmental change and climate shocks. However, current framings of “climate migration as adaptation” obscure how these adaptation pathways are constructed by existing power relations, leaving institutions liable to re-enforce inequality. This thesis uses the concept of “imaginaries” to de-construct how certain knowledge and values advance over others in the process of negotiating and acting towards a preferable future. It employs a dual methodological approach with a case study of Baan Non Daeng in Ubon Ratchathani, Thailand to analyze dominant imaginaries in Thailand and their function and limitations …

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Unpacking Gender Inequality For Inclusive Development: A Case Study Of Myanmar Female Migrant Workers In Samut Sakhon Province, Thailand, Hsan Thawdar Htun Jan 2022

Unpacking Gender Inequality For Inclusive Development: A Case Study Of Myanmar Female Migrant Workers In Samut Sakhon Province, Thailand, Hsan Thawdar Htun

Chulalongkorn University Theses and Dissertations (Chula ETD)

The study aims to address the issue of gender inequality in Thailand's seafood industry, with a specific focus on Myanmar female migrant workers in Mahachai (Samut Sakhon province). Although women migrant workers play a significant role in Thailand's economy, they have been facing various challenges in low-wage industries. Gender inequality remains a prominent concern in these low-skilled labor-intensive workplaces like seafood industry. While there have been studies on migration that include both men and women or focus solely on women, gender has not received sufficient emphasis in understanding the experiences of female migrant workers, particularly in the seafood industry. This …

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Migrant Trainees And Social Inclusion : A Study Of Construction And Electronics Company In Japan, Kazuhiro Watanabe Jan 2022

Migrant Trainees And Social Inclusion : A Study Of Construction And Electronics Company In Japan, Kazuhiro Watanabe

Chulalongkorn University Theses and Dissertations (Chula ETD)

This research analyzed the Technical Intern Training Program (TITP) by using the concept of social inclusion and discussed the factors that inhibit the social inclusion of trainees. Not much previous research on has been done on this because trainees are allowed to stay in Japan temporarily and they must go back to their home countries after the training is over. However, trainees contribute economic growth in Japan and play an important role for solving issues of the labor force. Realizing social inclusion of trainees is thus a significant issue for Japan. Factors that inhibit the social inclusion of trainees includes …

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Intersectionality And Livelihoods Of Conflict-Induced Displaced Myanmar Women In Mae Sot, Thailand, Su Myat Thwe Jan 2022

Intersectionality And Livelihoods Of Conflict-Induced Displaced Myanmar Women In Mae Sot, Thailand, Su Myat Thwe

Chulalongkorn University Theses and Dissertations (Chula ETD)

The Sustainable Development Goals Report (2022) highlighted the global displacement crisis as 24.5 million population impacted by conflict by mid-2021; 311 out of every 100,000 people worldwide seeking refuge outside their country of origin[1]. The cycle of migration to Thailand from Myanmar has a special history with many intersecting factors of forced migration and a new trend emerges following 1st February 2021: only 1,527 cases in 9 shelters[2]; 986,670 regularized as migrant workers in 2021[3]; tens of thousands of unrecorded. The role of Myanmar’s unsung heroines cannot go forgotten. From a sociocultural conservative country with a constitution drafted by a …

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Assessing The Contribution Of Thailand’S Poultry Agribusiness Towardsmitigating Climate Change, Tita Phairaksa Jan 2022

Assessing The Contribution Of Thailand’S Poultry Agribusiness Towardsmitigating Climate Change, Tita Phairaksa

Chulalongkorn University Theses and Dissertations (Chula ETD)

This research provides an overview of the Thailand agreement on greenhouse gas emissions, specifically focusing on the meat industry, and examines the roles of the government, private companies, and civil society in Thailand. Research indicates that the meat industry has significant environmental impacts, including greenhouse gas emissions, deforestation, and biodiversity loss. Livestock for meat consumption has been a major contributor to environmental issues such as climate change, water pollution, and deforestation. Livestock alone contributes a substantial percentage to global climate change. This issue has become a critical transboundary concern affecting not only one specific country or region. In response to …

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A Study On Government Lottery Buying Behavior : The Cases Of Thai Consumers In Bangkok And Korean Consumers In Seoul Using Online Questionnaire, Korakoj Tongboriboon Jan 2022

A Study On Government Lottery Buying Behavior : The Cases Of Thai Consumers In Bangkok And Korean Consumers In Seoul Using Online Questionnaire, Korakoj Tongboriboon

Chulalongkorn University Theses and Dissertations (Chula ETD)

The research investigates the important factors influencing the government’s lottery buying behavior. The objectives of this research are to study the behavior of the lottery consumers between Thai and Korean consumers. The number of participants of Thai and Korean consumers should be separated. Among the total of 864 consumers, 445 consumers are Thai and the other 419 are Korean. This research employs a quantitative research design, and the data is collected by a questionnaire as a research tool. The data is statistically analyzed by percentage, means, standard deviation, Chi-square and Logistic Regression.The results show that the differences between Thai and …

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The Influence Of K-Pop Thai Fan Loyalty On The Image Of Korean Male Idol: A Case Study Of Lim Youngmin, Nattanon Wongsantimeth Jan 2022

The Influence Of K-Pop Thai Fan Loyalty On The Image Of Korean Male Idol: A Case Study Of Lim Youngmin, Nattanon Wongsantimeth

Chulalongkorn University Theses and Dissertations (Chula ETD)

K-pop boyband artist AB6IX from South Korea, Lim Youngmin, has won the hearts of Thai fans that have developed into loyalness to him. However, Lim Youngmin has faced situations that affected the artist's idol image, and this resulted in the inability of performing as an artist in the meantime, from an incident in 2020, after being arrested for DUI - driving under the influence of alcohol. He had his driving license revoked in the same year which might force him to decide to enlist himself in the military, which is a requirement for all male citizens of South Korea without …

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Hallyu’S Media Hybridization: A Case Study Of A Korean Series Remake For Thai Audiences, Nutchapon Nimitphuwanai Jan 2022

Hallyu’S Media Hybridization: A Case Study Of A Korean Series Remake For Thai Audiences, Nutchapon Nimitphuwanai

Chulalongkorn University Theses and Dissertations (Chula ETD)

Korean culture has currently spread to many countries and benefited both the economy and society, but it also has the potential to integrate with those cultures. Hallyu is centered to the export of cultural products in order to further the spread of its culture throughout the world. Thailand is one of the countries that has been influenced by Hallyu, and the impact on Thai television has not exemplified cultural imperialism but hybridization. Hallyu, on the other hand, is not a single direction, but a composite of mixed and local reconstructions. Korean media imports are also incorporated into the local. Certain …

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Political Astronomy: South Korea Space Development Under The International Political Dimension, Nutnarin Ueasukpakdee Jan 2022

Political Astronomy: South Korea Space Development Under The International Political Dimension, Nutnarin Ueasukpakdee

Chulalongkorn University Theses and Dissertations (Chula ETD)

Human Knows about space technology development since 1950s era during that time U.S. and Soviet Union were main actors in “Space race” war. Space technology development of U.S. and Soviet Union in proxy war era were emphasized to develop for competition of political ideology and power of military. At the present time the purpose of space technology development different from the past, many countries that try to develop space technology for economic benefit, technology benefit, communication benefit or hidden connotation others. South Korea was the one that have potential and interesting to develop space technology because of the conflict with …

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Juxtaposition Images Of Two Koreas Portrayed In Crash Landing On You And Its Effect On Thai Audiences' Perspective, Phonpraphai Chanthanee Jan 2022

Juxtaposition Images Of Two Koreas Portrayed In Crash Landing On You And Its Effect On Thai Audiences' Perspective, Phonpraphai Chanthanee

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study examines the historical and political contexts of the two Koreas in terms of different ideologies that affect various elements of society by exploring insights into the backgrounds of South Korea and North Korea from a literature review. To analyze the disparities between the two nations, the research focuses on the scripts, visuals, and hidden agendas depicted in the renowned Korean series Crash Landing on You, along with investigating the production process and relevant interviews. In addition to exploring the narration, the study also surveyed the impact of the drama on the international perspective of the two Koreas through …

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Korean Migration And Hallyu: The Emergence Of Korean Celebrities In The Philippine Entertainment Industry, Rose Carmelle Lacuata Jan 2022

Korean Migration And Hallyu: The Emergence Of Korean Celebrities In The Philippine Entertainment Industry, Rose Carmelle Lacuata

Chulalongkorn University Theses and Dissertations (Chula ETD)

The Philippines is home to many Korean migrants, who started migrating to the Philippines in the 1990s for economic purposes, and later for educational purposes. As the Korean community in the Philippines continued to grow, they brought with them their own culture, with businesses catering to Koreans also increasing. Meanwhile, Hallyu or the Korean wave has been spreading like wildfire all over the world since it first became popular in China in the early 2000s, and the Philippines is one of the countries where Korean culture has become popular. Eventually, the Korean community in the Philippines, in one way or …

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Household Characteristics Of Indebted Households With Members Working In The Public And Private Sector, Kawita Niwatananun Jan 2022

Household Characteristics Of Indebted Households With Members Working In The Public And Private Sector, Kawita Niwatananun

Chulalongkorn University Theses and Dissertations (Chula ETD)

The research analyzed the influence of different household characteristics on household debt, including mortgage debt. Using data from Thailand’s Household Socio-Economic Survey in 2019 and 2021, the study implemented a logit model to identify household characteristics with significant impact on household debt. By analyzing data from two different periods that varied in social and economic contexts, the study highlighted critical factors that influenced household debt demand. The datasets were divided into three categories according to household work status. The categories include households with at least one public sector worker, households with no public sector workers but at least one private …

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Analyzing Two Opposing Opinions From Social Media Through Static And Contextualized Word Embeddings, Wassakorn Sarakul Jan 2022

Analyzing Two Opposing Opinions From Social Media Through Static And Contextualized Word Embeddings, Wassakorn Sarakul

Chulalongkorn University Theses and Dissertations (Chula ETD)

Public opinion analysis plays a vital role in various domains, such as marketing and politics. With the increasing volume of text data available through the internet and social media, efficient text-based analysis methods have become crucial. This study explores the application of static and contextualized word embeddings in word-based opinion analysis. The research questions focus on the impact of pre-training on static word embeddings, the efficacy of static and contextualized word embeddings in delineating opposing opinions, and the behavioral differences between the two embedding types. The findings suggest that pre-training improves embedding quality in small-sized datasets but may introduce noise …

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Connected Size Ramsey Numbers Of Matching And Some Graphs, Jirawat Mungtumklang Jan 2022

Connected Size Ramsey Numbers Of Matching And Some Graphs, Jirawat Mungtumklang

Chulalongkorn University Theses and Dissertations (Chula ETD)

No abstract provided.

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Simulation And Prototyping Of A Knee Assistive Device For Improved Gait Function, Khemwutta Pornpipatsakul Jan 2022

Simulation And Prototyping Of A Knee Assistive Device For Improved Gait Function, Khemwutta Pornpipatsakul

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study aimed to develop a knee-assistive device while walking. The research was separated into two sections: the gait support simulation in MATLAB and the prototype of the device. Data on body part positions and ground reaction force were collected from three adult Thai participants walking at a speed of 1.5 m/s to calculate knee moment. The simulation section provides support moments during walking using machine learning and artificial stiffness control strategy (MLASCS), composed of the kNN model and the instantaneous artificial stiffness per body mass (IASPB) equations. The MLASCS was used to determine the proper amount of support moment …

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Classification Of Bacteria And Fungi In Peritoneal Dialysis Fluids Of Patients With Chronic Kidney Disease Based On Metagenomic Analysis, Suthida Visedthorn Jan 2022

Classification Of Bacteria And Fungi In Peritoneal Dialysis Fluids Of Patients With Chronic Kidney Disease Based On Metagenomic Analysis, Suthida Visedthorn

Chulalongkorn University Theses and Dissertations (Chula ETD)

Chronic kidney disease (CKD) is a long-term condition where sustained damage of the renal parenchyma leads to the chronic deterioration of renal function that may gradually progress to end-stage kidney disease (ESKD). Peritoneal dialysis (PD) is a type of ESKD treatment that is beneficial to improve a patient's quality of life. However, PD-associated peritonitis is a major complication that contributes cause of death, and the detection of the pathogen provided a high culture-negative rate. This study aims to apply metagenomic approaches for identifying the bacteria and fungi in peritoneal dialysis effluent (PDE) of CKD patients based on the full-length 16S …

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Effects Of Different Serum Supplements On Piggybac Cd19 Chimeric Antigen Receptor T Cells, Mulita Sanyanusin Jan 2022

Effects Of Different Serum Supplements On Piggybac Cd19 Chimeric Antigen Receptor T Cells, Mulita Sanyanusin

Chulalongkorn University Theses and Dissertations (Chula ETD)

Chimeric Antigen Receptor (CAR) T cell is a novel therapy for relapse and refractory hematologic malignancy. Characteristics of CAR T cells is associated with clinical efficacy and toxicity. Type of serum supplements used during cultivation affect the immunophenotype and function of viral-based CAR T cells. This study explores the effect of serum supplements on non-viral piggyBac transposon CAR T cell production. PiggyBac CD19 CAR T cells were expanded in cultured conditions containing either fetal bovine serum, human AB serum, human platelet lysate or xeno-free serum replacement. Then, the effect of different serum supplements on cell expansion, transfection efficiency, immunophenotypes and …

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Macrophage Depletion Enhances Gut Dysbiosis And Severity In Sepsis Mouse Model, Pratsanee Hiengrach Jan 2022

Macrophage Depletion Enhances Gut Dysbiosis And Severity In Sepsis Mouse Model, Pratsanee Hiengrach

Chulalongkorn University Theses and Dissertations (Chula ETD)

Macrophage is vital players in the responsiveness of the innate immune system against injury or infection. Although macrophage depletion is well-known for some emerging therapies, such as osteoporosis, osteopenia, and decreasing tumor-associated macrophages in melanoma, dysfunction of macrophages leads to an inability of an appropriate immune response and implicated in various disease processes, especially intestinal macrophages that play a key role in the gut immune system and the regulation of gastrointestinal physiology. To obtain an understanding of the role of sepsis-associated macrophages, clodronate was used for the dysfunction of mouse macrophages with and without cecal ligation and puncture (CLP) sepsis. …

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