Digital Commons Network^™

Building Digital Twins Of The Human Immune System: Toward A Roadmap, Reinhard Laubenbacher, Anna Niarakis, Tomas Helikar, G. An, B. Shapiro, R. S. Malik-Sheriff, T. J. Sego, P. Macklin, J. A. Glazier

Department of Biochemistry: Faculty Publications

Digital twins, customized simulation models pioneered in industry, are beginning to be deployed in medicine and healthcare, with some major successes, for instance in cardiovascular diagnostics and in insulin pump control. Personalized computational models are also assisting in applications ranging from drug development to treatment optimization. More advanced medical digital twins will be essential to making precision medicine a reality. Because the immune system plays an important role in such a wide range of diseases and health conditions, from fighting pathogens to autoimmune disorders, digital twins of the immune system will have an especially high impact. However, their development presents …

Increased Signal Complexity Is Associated With Increased Mating Success, Noori Choi, Matt Adams, Kasey Fowler-Finn, Elise Knowlton, Malcolm Rosenthal, Aaron Rundus, Roger D. Santer, Dustin J. Wilgers, Eileen Hebets

Eileen Hebets Publications

The evolution of complex signals has often been explored by testing multiple functional hypotheses regarding how independent signal components provide selective benefits to offset the costs of their production. In the present study, we take a different approach by exploring the function of complexity per se. We test the hypothesis that increased vibratory signal complexity— based on both proportional and temporal patterning—provides selective benefits to courting male Schizocosa stridulans wolf spiders. In support of this hypothesis, all of our quantified metrics of vibratory signal complexity predicted the mating success of male S. stridulans. The rate of visual signalling, which is …

Emission Of Volatile Organic Compounds From Land-Applied Beef Cattle Manure As Affected By Application Method, Diet, And Soil Water Condition, Bryan L. Woodbury, John E. Gilley, David B. Parker, David B. Marx

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Land application of beef cattle manure may result in the emission of volatile organic compounds (VOC). This study was conducted to evaluate the effects of diet, land application method, soil water condition, and time since manure application on VOC emissions. Manure was collected from feedlot pens where cattle were fed diets containing 0%, 10%, or 30% wet distillers grains with solubles (WDGS). The effects of manure application method (surface-applied or incorporated) and soil water condition (saturated or wet) on VOC emissions were measured over a 48 h period. Heptanoic, hexanoic, isobutyric, and isovaleric acids contributed 23.5%, 17.6%, 9.26%, and 3.39% …

Unmanned Aerial System-Based Data Ferrying Over A Sensor Node Station Network In Maize, Jasreman Singh, Yufeng Ge, Derek M. Heeren, Elizabeth Walter-Shea, Christopher M. U. Neale, Suat Irmak, Mitchell S. Maguire

Department of Agricultural and Biological Systems Engineering: Faculty Publications

© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).

Sources Of Variability And Uncertainty In Food-Energy-Water Nexus Systems, Heydi Calderon-Ambelis, Deepak R. Keshwani

Department of Agricultural and Biological Systems Engineering: Faculty Publications

A nexus approach contributes to the strategic allocation of resources to secure food, energy, and water for the world population. Integrated models considering the complex interactions across food, energy, and water (FEW) enhance decision-making and strategic planning towards resilience. However, a significant number of the existing integrated models leave unaddressed the inherent variability and uncertainty present in the FEW sectors. Here, we review the importance of characterizing variability over spatial and temporal scales and the importance of decreasing the uncertainty present within a FEW nexus systems. The review also discusses existing modeling tools that address variability and uncertainty on single …

Comparison Effect On Biogas Production From Vegetable And Fruit Waste With Rumen Digesta Through Co-Digestion Process, Anika Tasnim, Muhammad Rashed Al Mamun, Md Anwar Hossen, Md Towfiqur Rahman, Md Janibul Alam Soeb

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Biogas is the best renewable energy as it can be produced from any biomass for example any plant or living organism. The purpose of this research was to produce biomethane from co-digestion of vegetable and fruit waste with rumen digesta through anaerobic digestion process. In this research, two trials of experiment were conducted. Each trial has three different sample with different mixing ratios. Raw materials used in the experiment was rumen digesta of goat and cow, potato, capsicum, cucumbers, onions, radish, cauliflower, carrot, leafy vegetables, apple, banana, and papaya. In each sample, 1200 gram of raw materials were used. Hydraulic …

Social Networks In The Single Cell, Moira Rodriguez, Ana Martinez-Hottovy, Alan C. Christensen

School of Biological Sciences: Faculty Publications

Plant mitochondrial DNA (mtDNA) can become damaged in many ways. A major repair mechanism is homologous recombination, which requires an undamaged DNA template. Presumably, this template comes from a different mitochondrion in the same cell. Plant mitochondria undergo fission and fusion to form transient networks which could allow the exchange of genetic information. To test this hypothesis, Chustecki et al. (2022) used msh1 mutants with defective DNA repair, and showed that mitochondrial interactions increased, revealing a link between the physical and genetic behavior of mitochondria.

Experimental Evaluation Of Ecological Principles To Understand And Modulate The Outcome Of Bacterial Strain Competition In Gut Microbiomes, Rafael R. Segura Munoz, Sara Mantz, Ines Martinez, Fuyong Li, Robert J. Schmaltz, Nicholas A. Pudlo, Karthik Urs, Eric C. Martens, Jens Walter, Amanda Ramer-Tait

Department of Food Science and Technology: Faculty Publications

It is unclear if coexistence theory can be applied to gut microbiomes to understand their characteristics and modulate their composition. Through experiments in gnotobiotic mice with complex microbiomes, we demonstrated that strains of Akkermansia muciniphila and Bacteroides vulgatus could only be established if microbiomes were devoid of these species. Strains of A. muciniphila showed strict competitive exclusion, while B. vulgatus strains coexisted but populations were still influenced by competitive interactions. These differences in competitive behavior were reflective of genomic variation within the two species, indicating considerable niche overlap for A. muciniphila strains and a broader niche space for B. vulgatus …

Thermal Inactivation Of Salmonella On Chicken Wings Cooked In Domestic Convection And Air Fryer Ovens, Carmen Cano, Xinyao Wei, Cyril A. Etaka, Byron D. Chaves

Department of Food Science and Technology: Faculty Publications

Chicken wings are among the most popular poultry products for home and foodservice consumption. Poultry products must be handled and cooked safely to decrease the risk of foodborne salmonellosis for consumers. This study aims to validate the use of domestic appliances (convection and air fryer ovens) for the thermal inactivation of Salmonella on chicken wings. Wings (n = 3, 46.5 ± 4.3 g) were inoculated with a five-strain cocktail of Salmonella (ca. 8 log₁₀ CFU/wing) and cooked in a convection oven (179.4ºC) or an air fryer (176, 190, or 204ºC) for 2, 5, 10, 15, 20, 22, or 25 …

Small Bowel Stomas Are Associated With Higher Risk Of Circulating Food-Specific-Igg Than Patients With Organic Gastrointestinal Conditions And Colostomies, Walker K. Carson, Joseph L. Baumert, Jennifer Clarke, Jacques Izard

Department of Food Science and Technology: Faculty Publications

Objective The effects of food sensitivity can easily be masked by other digestive symptoms in ostomates and are unknown. We investigated food-specific-IgG presence in ostomates relative to participants affected by other digestive diseases.

Design Food-specific-IgG was evaluated for 198 participants with a panel of 109 foods. Immunocompetency status was also tested. Jejunostomates, ileostomates, and colostomates were compared with individuals with digestive tract diseases with inflammatory components (periodontitis, eosinophilic esophagitis, duodenitis, ulcerative colitis, Crohn’s disease, and appendicitis), as well as food malabsorption due to intolerance. A logistic regression model with covariates was used to estimate the effect of the experimental data …

Analysing Bim Implementation In The Egyptian Construction Industry, Ayman Ahmed Ezzat Othman, Mohamed Marzouk, Heba Elsaay

Architectural Engineering

Purpose – This research is built up upon exploring the concepts of building information modeling (BIM) adoption and strategy formulation with the aim to develop a strategy for implementing BIM in the Egyptian construction industry. Design/methodology/approach – The development of the BIM implementation strategy was based on two pillars, namely the literature review and results of the survey questionnaire and interviews. First, the review of literature helped investigating the BIM challenges and international strategies developed to implement BIM worldwide. Findings – The research presented recommendations to assist policymakers in Egypt to facilitate BIM implementation. Originality/value – Although multiple frameworks have …

Achieving Sustainability Through Reducing Risks During Architecture Design Process: A Lean Management Perspective, Sherouk Abdelrehim, Ayman Ahmed Ezzat Othman

Architectural Engineering

The construction industry, as one of the largest industries in the world, plays a critical role in achieving national and international social and economic sustainable development goals. Socially, it is concerned with delivering long-term projects that turn client and end-user requirements into designs that specify technical aspects, functional specific requirements, and standards of quality. Economically, the construction industry contributes to a country's gross domestic product (GDP) by creating jobs and providing the country's infrastructure. the construction industry's nature is more vulnerable than other industries. This is believed to be due to the complex and dynamic nature of construction projects, as …

The Aesthetic Effect Of Photovoltaic Cells On The Building Facades, Khloud Khalid Eldamshiry

Architectural Engineering

Technological advancement in building incorporated photovoltaic (BIPV) has transformed the façade of the building into a generator powered by renewable energy sources. The BIPV facades are designed to provide energy production alongside traditional design goals such as aesthetics art and environmental control. However, the problem is that architectural design goals sometimes conflict with energy performance such as visibility and daylight versus maximum power output. In this context, the use of renewable energy sources such as solar energy seems to be worthwhile as they are numerous and have enormous environmental and economic prospects. This study aims to provide a new entrance …

An Examination Of Ethical Attitudes Towards Wild Pig (Sus Scrofa) Toxicants In The United States, Keith Carlisle, Erin E. Harper, Stephanie A. Shwiff

United States Department of Agriculture Wildlife Services: Staff Publications

This research aims to understand ethical attitudes of the U.S. public towards the use of a toxicant to control wild pigs (Sus scrofa), a destructive invasive species whose population growth is proving difficult to control through conventional management methods. Using a nationwide self-administered survey with 2,186 completed and returned questionnaires, we found that among six different lethal control methods, toxicant usage was the only method that a majority of respondents (51%) found to be unethical, with no significant differences between rural and urban respondents or between respondents from counties with wild pigs and counties where the species is absent. The …

Dietary Supplement Use By Individuals Living With And Beyond Cancer

Saudi Medical Journal

No abstract provided.

10th Global Conference On Health Promotion Charters A Path For Creating ‘Well-Being Societies’

Saudi Medical Journal

No abstract provided.

Addressing Big Tech's Market Power: A Comparative Institutional Analysis, Thomas A. Lambert

Faculty Publications

This Article provides a comparative institutional analysis of the three leading approaches to addressing the market power of large digital platforms: (1) traditional antitrust law, the approach thus far taken in the United States; (2) ex ante conduct rules, the approach embraced by the European Union's Digital Markets Act and several bills under consideration in the U.S. Congress; and (3) ongoing agency oversight, the approach embraced by the United Kingdom with its newly established "Digital Markets Unit." After identifying the general advantages and disadvantages of each approach, the Article examines how they are likely to play out in the context …

Borderplex Business Barometer, Volume 6, Number 1, Thomas M. Fullerton Jr., Steven L. Fullerton

Border Region Modeling Project

No abstract provided.

Mexico Consensus Economic Forecast, Volume 25, Number 1, Thomas M. Fullerton Jr., Steven L. Fullerton

Border Region Modeling Project

No abstract provided.

Data Analytics And Decision-Making Systems: Implications Of The Global Outbreaks, Desheng Wu, David L. Olson, James H. Lambert

Department of Supply Chain Management and Analytics: Faculty Publications

The COVID-19 pandemic has disrupted the goals and functions of technology-based systems around the world [16]. From a health perspective, the World Health Organization has reported that over six million have died of the disease. Government efforts to control the spread of COVID-19 have had drastic impact on global supply chains. The world’s health systems have been heavily taxed. Travel is difficult anywhere, and more difficult internationally. Economies are still in downturns [13], as many workers have been taken out of the economy for indefinite periods of time, and the structure of work has radically changed, with many working remotely …

Co-Use Among Confidants: An Examination Of Polysubstance Use And Personal Relationships In Southeastern Nebraska, G. Robin Gauthier, Kelly Markowski, Jeffrey A. Smith, Sela R. Harcey, Bergen Johnston

Department of Sociology: Faculty Publications

This study examines the relationship between personal networks and polysubstance use among people who use drugs (PWUD) in a medium sized city in the Midwest. A large body of work has demonstrated that personal relationships have an ambivalent association with substance use. On the one hand, a supportive network is associated with safer drug use practices and dramatically improves the outlook for recovery. However, individuals whose personal networks are composed of co-drug use partners are more likely to engage in risky practices. We argue that this notion of “supportive” social contacts and “risky” social contacts is ultimately incomplete: risky behaviors …

Why Neighborhoods (And How We Study Them) Matter For Adolescent Development, T.D. Warner, R.A. Settersten

Department of Sociology: Faculty Publications

Adolescence is a sensitive developmental period marked by significant changes that unfold across multiple contexts. As a central context of development, neighborhoods capture—in both physical and social space—the stratification of life chances and differential distribution of resources and risks. For some youth, neighborhoods are springboards to opportunities; for others, they are snares that constrain progress and limit the ability to avoid risks. Despite abundant research on “neighborhood effects,” scant attention has been paid to how neighborhoods are a product of social stratification forces that operate simultaneously to affect human development. Neighborhoods in the United States are the manifestation of three …

Is Perceived Inability To Procreate Associated With Life Satisfaction? Evidence From A German Panel Study, Julia Mcquillan, Jasmin Passet-Wittig, Arthur L. Greil, Martin Bujard

Department of Sociology: Faculty Publications

Most studies of the psychosocial consequences of infertility have focused on those who seek medical treatment, leaving a research gap regarding the psychosocial consequences of perceived inability to procreate in the general population. Moreover, most studies are cross-sectional and the results are thus likely affected by omitted variable bias. Inspired by aspects of the Theory of Conjunctural Action, this study analysed 10 waves of data from the German Family Panel (pairfam) for women and men using fixed effects panel regression and including time-varying control variables suggested by theory and research. This study found that both women and men experienced lower …

Family Violence, Personality Traits, And Risk Behaviors: Links To Dating Violence Victimization And Perpetration Among College Students, Kimberly A. Tyler, Douglas A. Brownridge

Department of Sociology: Faculty Publications

Though dating violence (DV) is prevalent on college campuses, few studies have examined a multitude of risk factors that may better explain this process. As such, we examined the role of family violence (i.e., childhood physical abuse, witnessing parental violence), personality traits (i.e., entitlement, antisocial personality [ASP] and borderline personality [BP]) and risk behaviors (i.e., risky sexual behaviors, heavy drinking, marijuana use, illicit drug use) on DV victimization and perpetration among 783 college students. Path analysis revealed that witnessing parental violence was linked to DV perpetration while experiencing more physical abuse was positively correlated with entitlement (females only), ASP traits, …

Improving Taxonomic Delimitation Of Fungal Species In The Age Of Genomics And Phenomics, Ashley Stengel, Kimberly M. Stanke, Amanda C. Quattrone, Joshua R. Herr

Department of Plant Pathology: Faculty Publications

Species concepts have long provided a source of debate among biologists. These lively debates have been important for reaching consensus on how to communicate across scientific disciplines and for advancing innovative strategies to study evolution, population biology, ecology, natural history, and disease epidemiology. Species concepts are also important for evaluating variability and diversity among communities, understanding biogeographical distributions, and identifying causal agents of disease across animal and plant hosts. While there have been many attempts to address the concept of species in the fungi, there are several concepts that have made taxonomic delimitation especially challenging. In this review we discuss …

Determining The Novel Pathogen Neodothiora Populina As The Causal Agent Of The Aspen Running Canker Disease In Alaska, Loretta M. Winton, Gerard C. Adams, Roger W. Ruess

Department of Plant Pathology: Faculty Publications

Neodothiora populina Crous, G.C. Adams & Winton was determined to be a new pathogen of trembling aspen (Populus tremuloides) growing in Alaska, based on completion of Koch's Postulates in replicated forest and growth chamber inoculation trials. The pathogen is responsible for severe damage and widespread rapid mortality of sapling to mature aspen (≥ 80 years) in the boreal forests of interior Alaska, due to large diffuse annual (1–2 years) cankers. Isolation of the pathogen was challenging, and identification based on cultural characters was difficult. Fruiting bodies were not found on wild diseased trees, but erumpent pycnidia were found …

Mis 5e Sea-Level History Along The Pacific Coast Of North America, Daniel R. Muhs

United States Geological Survey: Staff Publications

The primary last interglacial, marine isotope substage (MIS) 5e records on the Pacific coast of North America, from Washington (USA) to Baja California Sur (Mexico), are found in the deposits of erosional marine terraces. Warmer coasts along the southern Golfo de California host both erosional marine terraces and constructional coral reef terraces. Because the northern part of the region is tectonically active, MIS 5e terrace elevations vary considerably, from a few meters above sea level to as much as 70m above sea level. The primary paleo-sea-level indicator is the shoreline angle, the junction of the wave-cut platform with the former …

Frugivory And Seed Dispersal By Carnivorans, John P. Draper, Julie K. Young, Eugene W. Schupp, Noelle G. Beckman, Trisha B. Atwood

United States Department of Agriculture Wildlife Services: Staff Publications

Seed dispersal is critical to the ecological performance of sexually reproducing plant species and the communities that they form. The Mammalian order Carnivora provide valuable and effective seed dispersal services but tend to be overlooked in much of the seed dispersal literature. Here we review the literature on the role of Carnivorans in seed dispersal, with a literature search in the Scopus reference database. Overall, we found that Carnivorans are prolific seed dispersers. Carnivorans’ diverse and plastic diets allow them to consume large volumes of over a hundred families of fruit and disperse large quantities of seeds across landscapes. Gut …

Aboveground Carbon Responses To Experimental And Natural Hurricane Impacts In A Subtropical Wet Forest In Puerto Rico, Hervé Chevalier, Nicholas V.L. Brokaw, Sheila E. Ward, Jess K. Zimmerman, Aaron B. Shiels, John Bithorn, Samuel Matta Carmona

United States Department of Agriculture Wildlife Services: Staff Publications

Climate change and disturbance make it difficult to project long-term patterns of carbon sequestration in tropical forests, but large ecosystem experiments in these forests can inform predictions. The Canopy Trimming Experiment (CTE) manipulates two key components of hurricane disturbance, canopy openness and detritus deposition, in a tropical forest in Puerto Rico. We documented how the CTE and a real hurricane affected tree recruitment, biomass, and aboveground carbon storage over 15 years. In the CTE treatments, we trimmed branches, but we did not fell trees. We expected that during the 14-year period after initial canopy trimming, regrowth of branches and stems …

Behavioral States In Space And Time: Understanding Landscape Use By An Invasive Mammal, Steven M. Gray, John M. Humphreys, Robert A. Montgomery, Dwayne R. Etter, Kurt C. Vercauteren, Daniel B. Kramer, Gary J. Roloff

United States Department of Agriculture Wildlife Services: Staff Publications

Animal movement models can be used to understand species behavior and assist with implementation of management activities. We explored behavioral states of an invasive wild pig (Sus scrofa) population that recently colonized central Michigan, USA, 2014–2018. To quantify environmental factors related to wild pig movement ecology and spatio‐temporal landscape use, we predicted wild pig behavioral states relative to land cover type, landscape structure (i.e., edge and patch cohesion), and weather conditions. We used global positioning system (GPS)‐collars and monitored 8 wild pigs from 2014–2018. We fit local convex hulls and calculated movement metrics revealing 3 wild pig behavioral states (resting, …