Digital Commons Network^™

Ketogenic Diet Dampens Excitatory Neurotransmission By Shrinking Synaptic Vesicle Pools, Marion I Stunault, Pan-Yue Deng, Anjali Yadav, Erica M Periandri, Francisca N De Luna Vitorino, Michael B Thomsen, Jasmin Sponagel, Amelia J Barfield, Renzelle J Ponce, Layla Foroughi, Benjamin A Garcia, Gabor Egervari, Vitaly A Klyachko, Ghazaleh Ashrafi

2020-Current year OA Pubs

Ketogenic diet (KD) is used for the treatment of drug-resistant childhood epilepsy and has been proposed to improve outcomes in neurodegenerative diseases. However, the mechanisms by which KD alters brain circuitry remain unclear. Here, we investigated the impact of KD on hippocampal function through integrative analysis of gene expression and neurotransmission. We found that KD induces extensive transcriptional reprogramming, including altered expression of numerous synaptic genes. Proteomic and genomic profiling revealed significant changes in histone modifications, particularly at promoters of KD-regulated genes. Electrophysiological recordings showed that KD reduces excitatory synaptic gain and short-term plasticity at CA3-CA1 synapses, dampening the summation …

Estimating The Baseline Age When Longitudinal Changes In Biomarkers Accelerate: Application To An Imaging Study Of Preclinical Alzheimer Disease, Chengjie Xiong, Folasade Agboola, Jingqin Luo

2020-Current year OA Pubs

BACKGROUND: Biomarkers are routinely measured from human biospecimens and imaging scans in Alzheimer disease (AD) research. Age is a well-known risk factor for AD. Detecting the baseline age at which the longitudinal change in biomarkers starts to accelerate is important to design preventive interventions. METHODS: We analyzed longitudinal biomarker data by a random intercept and random slope model where the slope (longitudinal rate of change) was modeled as a piecewise linear and continuous function of baseline age. We proposed to estimate the baseline age at the intersection of the two linear functions by multiple methods: maximum (profile) likelihood, minimum squared …

Applying Frame-Is To Characterize Provider-Led Adaptations To A Cervical Cancer Prevention Intervention In Kenya, Harriet Fridah Adhiambo, Katherine Thomas, Megan M Coe, Lynda Oluoch, Valary Ihaji, Mary Bernadette Kerubo, Alex Kinyua, Sarah Njoroge, Kenneth Ngure, Michelle Shin, Thomas A Odeny, Bryan Weiner, Nelly Mugo, Sarah Gimbel

2020-Current year OA Pubs

BACKGROUND: Implementation strategies that are contextually refined are essential for optimizing the delivery of evidence-based interventions (EBI) to prevent cervical cancer in low-resource settings. This paper reports the application of the Framework for Reporting Adaptations and Modifications to Evidence-based Implementation Strategies (FRAME-IS) to capture and disseminate strategy adaptations made to a single-visit, screen-and-treat approach with thermal ablation (SV-SAT + TA) strategy aimed at establishing sustainable cervical cancer prevention services in Kenya.

METHODS: A FRAME-IS-based tracking spreadsheet was developed to document bundled site-specific implementation strategy adaptations and across 10 facilities. Data was collected during technical assistants' (TAs) site visits, phone calls, …

Only Americans Left Behind: Iran’S Illegal Use Of Hostages As Political Pawns To Advance Their Foreign Policy, Ava Namazi

San Diego International Law Journal

The Islamic Republic of Iran has emerged as one of the most prominent contemporary practitioners of hostage diplomacy—a strategy rooted in the 1979 Hostage Crisis and sustained through recurring detentions of foreign nationals on fabricated security charges. The government uses innocent foreign nationals as political pawns to coerce Western states, including the United States, to release frozen Iranian assets held abroad. This Comment situates Iran’s use of hostage diplomacy within its post-revolutionary foreign policy, examining how the collapse of the Pahlavi dynasty contributed to this tactic. Additionally, this Comment will analyze the current international legal frameworks governing hostage diplomacy and …

An International Human Rights-Based Approach To Reducing Maternal Mortality And Enhancing Safe Motherhood In Africa, John Mukum Mbaku

San Diego International Law Journal

In 2015, the U.N. General Assembly (UNGA) noted that almost fifteen years after the global community had agreed to the Millennium Development Goals (MDGs), which provided an important framework for economic and human development, significant progress has been made in several areas. However, the UNGA explained that many developing countries have not been able to achieve the MDGs, especially those goals related to maternal and reproductive health. Although the global maternal mortality rate has declined significantly, only 50% of pregnant women in developing countries receive the recommended minimum of four antenatal care visits. Additionally, complications suffered during pregnancy and childbirth …

Seamless Security: Reforming Export Controls For A Stronger Allied Defense Industrial Base, Justin Belcher

San Diego International Law Journal

Russia’s invasion of Ukraine and China’s accelerating military modernization underscore the need for the United States and its allies to reinforce their defense industrial bases to deter and prevail in future conflicts. This paper examines the historical and strategic foundations driving the need for export control reform, identifies key U.S. export control laws governing defense coproduction and co-development, and analyzes how current regulations constrain allied industrial integration. It concludes by proposing solutions to streamline export control regulations to improve the strength and resilience of the modern defense industrial base.

Beyond The Cisg: Utilizing Unidroit Principles To Synchronize International Contract Law Beyond Sales Of Goods, Noor Albandar

San Diego International Law Journal

Modern advancements have made it easier than ever for individuals and businesses to enter into cross-border transactions. Contract law in the United States employs legal instruments such as the UCC to aid contracting parties, and international law consists of tools such as the CISG supporting cross-border contracts for the sale of goods. Such tools are important because international transactions for goods occur frequently. This Comment will examine the complexities that arise in the face of international contracts, discuss tools for uniform law that are currently utilized by various governing bodies, and propose further implementation of uniform international contract law. In …

Electric Pressure Cookers: What You Need To Know, Callahan Adams, Emily Smith

All Current Publications

Electric pressure cookers (EPCs) offer convenience, versatility, and efficiency in everyday cooking. EPCs offer multiple cooking functions beyond pressure cooking, including sautéing, slow cooking, steaming, cooking rice, and preparing yogurt. They are not suitable for pressure canning, as confirmed by multiple Extension research studies and national guidelines. When used properly, EPCs provide a safe and effective way to prepare meals quickly while saving counter and storage space.

Hybrid Vision Transformer–Cnn Framework For Alzheimer’S Disease Cell Type Classification: A Comparative Study With Vision–Language Models, Md Easin Hasan, Md Tahmid Hasan Fuad, Omar Sharif, Amy Wagler

School of Mathematical & Statistical Sciences Faculty Publications

Accurate identification of Alzheimer’s disease (AD)-related cellular characteristics from microscopy images is essential for understanding neurodegenerative mechanisms at the cellular level. While most computational approaches focus on macroscopic neuroimaging modalities, cell type classification from microscopy remains relatively underexplored. In this study, we propose a hybrid vision transformer–convolutional neural network (ViT–CNN) framework that integrates DeiT-Small and EfficientNet-B7 to classify three AD-related cell types—astrocytes, cortical neurons, and SH-SY5Y neuroblastoma cells—from phase-contrast microscopy images. We perform a comparative evaluation against conventional CNN architectures (DenseNet, ResNet, InceptionNet, and MobileNet) and prompt-based multimodal vision–language models (GPT-5, GPT-4o, and Gemini 2.5-Flash) using zero-shot, few-shot, and chain-of-thought …

Safety And Feasibility During Early Implementation Of Robotic-Assisted Percutaneous Coronary Intervention, Dung Thuong Ho, Manh Cuong Nguyen, Tran Tran Nguyen, Long Tran, Huy Nguyen, Dil Mai, Tuong Mien Ngo, Duc Chinh Nguyen, Chi Cuong Tran, Khiem D. Ngo

School of Medicine Publications

Background: Robotic-assisted Percutaneous Coronary Intervention (R-PCI) is an advanced technique offering potential advantages for both patients and interventional cardiology practices. In 2023, Can Tho S.I.S General Hospital implemented its first robotic system for PCI procedures. This study aimed to evaluate the safety and clinical outcomes during the early learning curve of R-PCI.

Methods: This prospective study included all patients undergoing R-PCI with the CorPath GRX Vascular Robotic System at Can Tho S.I.S General Hospital from April to September 2023. Baseline patient characteristics, procedural details, and six-month follow-up data were collected. Primary outcomes included Clinical Success, defined as < 30% residual diameter stenosis in the target vessel without major adverse cardiovascular events (MACE) during hospitalization (e.g., death, myocardial infarction, target-vessel revascularization, stroke), and robotic success, defined as achieving clinical success with partial manual support or no manual support.

Results: Thirty-one patients …

Prevalence And Predictors Of Inappropriate Antibiotic Prescriptions Among Dentists In Muscat Governorate, Oman, Wajiha Abdul Majeed Al-Lawati, Manar Alsanaa Ali Alzeedi, Elham Mohammadi, Noora Alhosni

Sultan Qaboos University Medical Journal

Objectives: Inappropriate antibiotic prescriptions represent a major healthcare concern, contributing to increasing antimicrobial resistance. Dentists account for up to 10% of antibiotic prescriptions, highlighting the need for rational prescribing practices. This study aimed to assess the prevalence and predictors of inappropriate antibiotic prescriptions by dentists in primary health clinics in Muscat Governorate, Oman. Methods: This retrospective cross-sectional study was conducted on dental antibiotic prescriptions issued between July and December 2024 in government and private dental care facilities across Muscat Governorate. Clinics were randomly selected and data were extracted from electronic patient records using a structured form. Descriptive statistics, Chi-square tests …

Synthesis Of Data Products For Ocean Carbonate Chemistry, Li Qing Jiang, Amanda Fay, Jens Daniel Müller, Luke Gregor, Alizée Roobaert, Lydia Keppler, Dustin Carroll, Siv K. Lauvset, Tim Devries, Judith Hauck, Christian Rödenbeck, Nicolas Metzl, Andrea J. Fassbender, Jean Pierre Gattuso, Peter Landschützer, Rik Wanninkhof, Christopher Sabine, Simone R. Alin, Mario Hoppema

Faculty Research, Scholarly, and Creative Activity

As the largest active carbon reservoir on Earth, the ocean is a cornerstone of the global carbon cycle, playing a pivotal role in modulating ocean health and the Earth’s climate system. Understanding these crucial roles requires access to a broad array of data products documenting the changing chemistry of the global ocean as a vast and interconnected system. This review article provides an overview of 68 existing ocean carbonate chemistry data products and data product sets, encompassing compilations of cruise datasets, derived gap-filled data products, model simulations, and compilations thereof. It is intended to help researchers identify and access data …

Motion To Approve Revisions To The Articles Of Authorities - April 2013 Version – Article Ii And Article Iii, Faculty Senate, Academic Policies Committee

Faculty Senate Motions

A Motion to Approve Revisions to the Articles of Authorities - April 2013 version – Article II and Article III

Motion In Defense Of Academic Freedom And Tenure, Faculty Senate

Faculty Senate Motions

A Motion in Defense of Academic Freedom and Tenure

Tendon Transfers After Midfoot Amputations: Limb Salvage, Erin Finn, Steven Smith, Brandon Kunz

Advocate GME

No abstract provided.

An Examination Of Trends And Factors Influencing Teen Retention In 4-H Youth Development Program: A Case Study, Bethany R. Corona

LSU Master's Theses

Teen participation in 4-H has declined nationally in recent years, raising concerns about long-term program sustainability and youth engagement. Understanding the factors that influence teens’ decisions to remain involved in 4-H is critical for informing program design and delivery. Guided by the theory of planned behavior, this qualitative study explored teen perceptions of 4-H programming, youth voice, social influences, communication, and barriers to participation. Data were collected through two group interviews with teen 4-H members representing multiple parishes. Interviews were audio recorded, transcribed verbatim, and analyzed using the constant comparative method through a three-phase coding process consisting of open, axial, …

Feasibility, Acceptability And Implementation Of A Whole-Family Mental Health Intervention For Displaced Adolescent Girls In Colombia: A Mixed-Methods Pilot Randomized Controlled Trial, Ilana Seff, Arturo Harker Roa, Byron Powell, Natalia Cordoba, Carolina Rodriguez, Julianne Deitch, Elvia Tamaity Ariza Pena, Feven Gebrekidan, Lindsay Stark

2020-Current year OA Pubs

Adolescent girls affected by displacement face substantial mental-health risks. The Sibling Support for Adolescent Girls in Emergencies (SSAGE) is a 12-week, gender-transformative, family-based program designed to improve adolescent girls' mental health in humanitarian settings. This mixed-methods pilot randomized controlled trial (RCT) assessed SSAGE's feasibility, acceptability and potential effects among 186 Venezuelan migrant and Colombian returnee families in Colombia. Adolescent girls aged 13-19 years, their male siblings and caregivers participated in parallel sessions on gender dynamics, communication and relationships. Implementation outcomes drew on the Mental Health Implementation Science Tools (acceptability and feasibility subscales), attendance records and qualitative interviews. Analyses followed an …

Increasing Ketamine Administration In Children's Hospitals For Youth With Sickle Cell Disease., Ashley M. Jenkins, Erin Hendry, Alexandra Power-Hays, Marin Valentino, Matthew Hall, Kathyrn Kyler, James W. Antoon, Sonya Tang Girdwood, Jennifer Goldman, Armand N. Morel, Timothy J. Savage, Lucas E. Orth, Natasha M. Archer

Manuscripts, Articles, Book Chapters and Other Papers

Ketamine is recommended as an opioid-sparing adjunct for sickle cell disease (SCD)-related pain management. Little is known regarding its use in hospitalized youth with SCD. We aimed to describe trends in ketamine administration and examine associations between ketamine administration and outcomes in hospitalized youth with SCD. We conducted a cross-sectional, multicenter study examining hospital admissions for youth with SCD from 44 children's hospitals in the United States from 2016 to 2023. Youth aged ≥6 months with SCD were identified using International Classification of Diseases tenth revision codes. Exposures included age, sex, race, payor, childhood opportunity index, hydroxyurea administration, and concomitant …

Regional Brain Age Is Decreased In Children With Sickle Cell Anemia, Amy E Mirro, Landon C Power, Jinli Wang, Paula Germino-Watnick, Heather Roberts, Yonca Cam, Kristin P Guilliams, Slim Fellah, Yasheng Chen, Hongyu An, Jin-Moo Lee, Andria L Ford, Melanie E Fields

2020-Current year OA Pubs

DeepBrainNet, a machine learning tool, uses magnetic resonance imaging (MRI) to predict an individual's brain age, allowing calculation of the brain age gap (predicted chronological age) for use as a biomarker of brain health. We tested the DeepBrainNet tool in sickle cell anemia (SCA) on 210 brain MRIs from 130 children (90 with SCA; 40 healthy controls) to investigate the hypothesis that children with SCA would have a younger predicted brain age than healthy controls as an index of aberrant brain development. DeepBrainNet estimates brain age from 80 axial slices of each brain, with the median used as global brain …

Benefit Of Rituximab Maintenance After First-Line Bendamustine-Rituximab In Patients With Mantle Cell Lymphoma, Yucai Wang, Imran A Nizamuddin, Brad S Kahl, Et Al.

2020-Current year OA Pubs

The benefit of rituximab maintenance after first-line (1L) bendamustine-rituximab (BR) in patients with mantle cell lymphoma (MCL) remains uncertain, with inconsistent results from the phase 2 MAINTAIN trial and several retrospective studies. We conducted a large retrospective study at 27 US and Canadian academic centers to examine the benefit of rituximab maintenance after BR. A total of 911 patients received 1L BR between 2010 and 2020, and 703 had an objective response and no evidence of disease progression at the 3-month post-BR landmark. Among those, 394 (56%) received rituximab maintenance and 309 (44%) did not, with largely similar baseline patient …

The George-Anne Daily, Georgia Southern University

George-Anne Media Group: Newsletters & Magazines

No abstract provided.

Tetramethylbenzidine Loaded Pva Nanofibers Strip For Visual Detection Of Hydrogen Peroxide Via Cu2+ Catalysis And Its Applications, Samar A. Salim

Nanotechnology Research Centre

Background Advancements in sensor technology have facilitated the development of cost-effective and highly sensitive sensors which have significantly improved the detection of biological analytes in various fields. This study presents a novel approach for the detection of hydrogen peroxide (H₂O₂), a critical analyte in both biological and environmental systems. A simple and sensitive colorimetric sensing platform was developed based on polyvinyl alcohol (PVA) nanofibers loaded with tetramethylbenzidine (TMB). Results The nanofibers were characterized using scanning electron microscopy, confirming the formation of smooth, spindle-shaped fibers with diameters from 324 to 551 nm. The colorimetric detection method utilized TMB, which undergoes oxidation …

"The Only Place I Feel Understood": A Mixed Methods Survey Of Adolescent And Caregiver Perspectives On Social Media And Parental Controls, Melanie Watt Ramos, Constance M Wiemann, Lauren A Bretz

Faculty, Staff and Students Publications

Purpose

Methods

Results

Mencari Pengaturan Dan Perlindungan Desain Industri, Felix Oentoeng Soebagjo, S.H., Ll.M.

Jurnal Hukum & Pembangunan

Abstract

Unifikasi Hukum Dagang Internasional Oleh Organisasi-Organisasi Internasional, Prof. Dr. Mr. Sudargo Gautama

Jurnal Hukum & Pembangunan

Abstract

Unifikasi Dan Harmonisasi Hukum Dagang Internasional Usaha Negara-Negara Asia-Afrika Dan Uncitral, Prof. Dr. Mr. Sudargo Gautama

Jurnal Hukum & Pembangunan

Abstract

Sikap Indonesia Terhadap Perjanjian Internasional Yang Dibuat Pemerintah Belanda, D. Sidik Suraputra, S.H.

Jurnal Hukum & Pembangunan

Abstract

Effect Of Cooking Methods On Lead (Pb) In Pasig River-Sourced Tilapia (Oreochromis Niloticus), Rhian Joy M. Romero, Mary Rosendahl D. Monteverde, Francesca Simone A. Remorozo, Lizel P. Bonifacio, John Albert D. Gurtiza

DLSU Senior High School Research Congress Conference Proceedings

Once declared biologically dead, the Pasig River now shows signs of aquatic life but remains heavily polluted with heavy metals like lead (Pb), which accumulate in fish and pose health risks. Despite this, many communities still rely on the river for food, particularly tilapia. This study addresses public health concerns by evaluating whether common cooking methods—frying, grilling, and steaming can reduce Pb levels in tilapia (Oreochromis niloticus) from the Pasig River to safe levels for consumption. A total of 107 tilapia samples were collected from Barangay Hulo, Mandaluyong City. The fish were cleaned, grouped, and cooked for 25 minutes using …

Tinjauan Terhadap Perkembangan Delik-Delik Khusus Masyarakat Yang Mengalami Modernisasi, Mardjono Reksodiputro, S.H., M.A.

Jurnal Hukum & Pembangunan

Abstract

Relationship Between Vegetation Greenness (Ndvi) And Land Surface Temperature Across Land Cover Types In Ciwidey Sub-Watershed (1990–2020), Syal Syabila, Kuswantoro Marko, Revi Hernina

Jurnal Geografi Lingkungan Tropik (Journal of Geography of Tropical Environments)

Land cover change significantly influences vegetation greenness and land surface temperature (LST), particularly in upstream watershed regions experiencing rapid development. This study aims to analyze changes in vegetation greenness (NDVI), land surface temperature, and their relationship across different land cover types in the Ciwidey Sub-Watershed, Bandung Regency, during 1990–2020. Landsat 5 TM and Landsat 8 OLI images (Path/Row 122/65) acquired in July 1990, 2005, and 2020 were processed using radiometric correction, supervised classification (Maximum Likelihood), NDVI extraction, and mono-window LST algorithm. Land cover classification accuracy was assessed using confusion matrix analysis. Linear regression was applied to evaluate the relationship between …