Digital Commons Network^™

Role Of Piezo1 Channels Expressed In Pvn In Regulating Sympathetic Nerve Activity And Arterial Blood Pressure In Rats, Yue Chen, Wei Guo, Jichun Wang, Min Wang, Yuying Yang, Gregory Miodonski, Enshe Jiang, Qing Hui Chen, Yi Yang, Renjun Wang

Michigan Tech Publications

Mechanosensitive Piezo1 channels participate in regulating pain sensitivity, insulin secretion, and vascular tension; however, their expression in the autonomic paraventricular nucleus (PVN) and role in modulating sympathetic outflow and cardiovascular function remain unstudied. In this study, unilateral PVN microinjection of the Piezo1 channel blocker Dooku1 (0.1, 1, 10, 100, and 200 pmol) administered to anesthetized male rats increased renal sympathetic nerve activity (RSNA) and mean artery pressure (MAP) in a dose-dependent manner, with maximum increases of 93 ± 30% (p < 0.0001) and 21 ± 5 mmHg (p < 0.0001), respectively, elicited by Dooku1 at 100 pmol. Similarly, PVN microinjection of the peptide Piezo1 channel blocker GsMTx4 (1 nmol) significantly increased RSNA (p < 0.001) and MAP (p < 0.0001). Conversely, PVN-microinjected Piezo1 channel activators Yoda1 (5 nmol) and Jedi2 (5 nmol) did not significantly alter RSNA or MAP. Western blot and qRT-PCR analyses of the hypothalamic PVN showed abundant Piezo1 mRNA and protein expression. Immunofluorescence detection showed that Piezo1 was expressed in pre-sympathetic PVN neurons with axons projecting to the rostral ventrolateral medulla. We conclude that Piezo1 channels expressed in the autonomic PVN neurons play an important role in regulating sympathetic outflow and cardiovascular function.

Simulating Cyber-Resilience: The Strategic Role Of The Locked Shields Exercise In Enhancing International Cyber Preparedness, Christopher A. Ramezan, Ludwig Christian Schaupp, Elizabeth A. Vitullo, William J. Walker

Journal of Cybersecurity Education, Research and Practice

As cyberthreats to critical infrastructure remain prevalent, national response mechanisms must evolve beyond the technical domain to incorporate legal, communicative, strategic, and cross-sector coordination. This work explores Locked Shields, an annual exercise conducted by NATO's Cooperative Cyber Defence Centre of Excellence, as a pedagogical and conceptual framework for simulating whole-of-government responses to cyber incidents. Unlike traditional cyber exercises, Locked Shields engages legal advisors, media strategists, and civil-military roles in realistic, scenario-driven simulations that portray the political and operational conditions of a real international-scale cyber crisis. We detail the exercise architecture, contrast with other cyber exercises, and assess its pedagogical and …

University Of Northern Iowa Faculty Senate Meeting Minutes, February 23, 2026, University Of Northern Iowa. Faculty Senate.

Documents - Faculty Senate

Meeting minutes from the Faculty Senate of the University of Northern Iowa.

Vol. 70, No. 7 (February 23, 2026)

Indiana Law Annotated

No abstract provided.

Faculty Senate Xxx 2025-2026 - February 23, 2026 Agenda, Faculty Senate

Faculty Senate Agendas & Minutes

No abstract provided.

Quenching-Based Electrochemiluminescence Detection Of Chlorpyrifos Using A Portable Sensor Platform, Emre Dokuzparmak

Turkish Journal of Biology

Background/aim: Chlorpyrifos (CPF) is an organophosphate pesticide extensively used in agriculture, posing significant threats to human health due to its neurotoxic effects. Its presence in food products has raised considerable public health concerns, necessitating the development of rapid, sensitive, and reliable detection methods. This study aims to design and validate an electrochemiluminescence (ECL) sensor platform operating via a quenching-based mechanism to enable ultrasensitive detection of CPF in food matrices.

Materials and methods: The sensing strategy exploits the coreactant mechanism between 2-(dibutylamino)ethanol (DBAE) and [Ru(bpy)₃]²+ (tris(2,2′-bipyridyl)ruthenium(II)), wherein CPF suppresses the ECL emission by interfering with the excited-state electron transfer pathway. The …

Investigation Of Antimicrobial Synergism Of Actinomycin Derivatives From Streptomyces Parvus 35m1 Against Escherichia Coli Atcc 25922, Özge Can, Mustafa Ünver Kurt, Meli̇s Küçüksolak, Ataç Uzel, Erdal Bedi̇r

Turkish Journal of Biology

Background/aim: Limited drug development and increased antibiotic tolerance among Gram-negative bacteria have led researchers to consider combination therapy. Actinomycin derivatives, particularly actinomycin D, exhibit a wide range of bioactivities, including antibacterial effects. However, actinomycin D is less effective against Gram-negative pathogens. Therefore, it is essential to demonstrate the synergy of actinomycin D and its derivatives with clinically known antibiotics against Escherichia coli ATCC 25922 and investigate the effects on cellular morphology.

Materials and methods: Streptomyces parvus 35M1 isolated from coastal sediment in İzmir/Türkiye was identified via genome sequencing. Large-scale (30 L) fermentation followed by chromatographic purification yielded compounds 1 (actinomycin …

Transcriptomic Identification And Developmental Mapping Of Nrg3b Expression In Zebrafish, Elham Tarahomi, Nuray Soğünmez Erdoğan

Turkish Journal of Biology

Background/aim: Neuregulin 3 (NRG3) is an epidermal growth factor-like ligand that is involved in neuronal circuit formation in mammals. However, the expression profile of its zebrafish ortholog, nrg3b, remains poorly defined. The transcriptomic analyses of zebrafish sco-spondin mutants, which display alterations in their neurodevelopmental pathways, have indicated potential dysregulation of Nrg3b. Guided by these insights, this study aimed to characterize the temporal and spatial expression patterns of nrg3b in vivo in embryonic and adult zebrafish.

Materials and methods: Publicly available RNA-seq data from heterozygous and maternal-zygotic zebrafish sco-spondin mutants at 5, 15, and 30 days postfertilization (dpf) were analyzed to …

Biological Evaluation Of Novel 6,9-Disubstituted Purine Analogues In High-Grade Serous Ovarian Cancer Cell Lines, Duygu Altiparmak, Deren Demi̇rel Yavuz, Pinar Kul Karadeni̇zli̇, İrem Durmaz Şahi̇n, Meral Tunçbi̇lek

Turkish Journal of Biology

Background/aim: High-grade serous ovarian cancer (HGSOC) remains one of the most aggressive forms of ovarian malignancy and frequently shows resistance to conventional therapies. This study aimed to synthesize a novel series of purine analogues, 6-[(4-substituted benzyl amine)/(4-substituted aniline)]-9-cyclopentyl purines, and evaluate their anticancer efficacy against HGSOC cell lines.

Materials and methods: We assessed the biological effects of the synthesized purine analogues on the OVCAR3, OVSAHO, and KURAMOCHI HGSOC cell lines using the sulforhodamine B assay. To investigate the mechanism of action, we conducted flow cytometry and western blot analyses, focusing on DNA replication and apoptosis.

Results: Among the tested compounds, …

Crow's Nest, February 23, 2026, Crow's Nest Staff

Crow's Nest

The February 23, 2026 issue of Crow's Nest.

Optimizing Patient Adherence Through Improved Technology-Based Communication By Enhancing Staff Efficiency At An Opiate Treatment Program Clinic, Jennifer Parsons

Doctor of Nursing Practice Projects

High rates of missed appointments and unreliable follow-up remain a problem in outpatient opioid treatment clinics. This project improved the communication workflow at a methadone maintenance clinic by strengthening reminder systems and staff coordination. A needs assessment found several problems: appointment reminders were inconsistent, tracking was unreliable, and staff communication often relied on manual handoffs. The project was to test a technology-based workflow designed to improve staff communication and reduce missed appointments. The Technology Acceptance Model and Lewin’s Change Theory guided the change. The clinic implemented automated reminders, secure messaging, and clearer documentation to support daily communication. A pre-post evaluation …

P*Law Week 2026: Student-Led Expert Panels Focusing On Public Service Law, Benjamin N. Cardozo School Of Law

Cardozo Law News Archive

Cardozo School of Law's annual Public Law Advocacy Week (P*LAW), hosted by the Center for Public Service Law, featured student-led panels on disability rights, labor law, LGBTQ+ rights, immigration law, environmental law, and international accountability. The event brought together students, alumni, faculty, and practitioners to discuss pressing public interest issues and careers in public service law.

Mcsa Forum Minutes 02/23/2026, Morris Campus Student Association

Morris Campus Student Association

No abstract provided.

Digital Competence Of Primary School Teachers In Andalusia (Spain): A Multidimensional Analysis Based On Self-Perceptions, Francisco Ábalos-Aguilera, Luis M. Romero-Rodríguez, Bárbara Mercedes Castillo Abdul Hadi

Artículos científicos

This study analyzes the self-perception of digital teaching competence (DTC) among primary education teachers in Andalusia, using an instrument based on the European DigCompEdu framework. Data were collected through a self-administered online questionnaire applied to a sample of 416 primary education teachers working in Andalusia. The study employed a mixed-methods design, combining quantitative analyses (descriptive, correlational, and comparative) with qualitative analysis of open-ended responses. Employing a mixed-methods approach, the research assesses teachers’ competence levels and examines differences according to professional experience, school ownership, teaching specialization, and territorial distribution. Results indicate that most teachers perceive themselves at intermediate levels of digital …

Shifting Focus: Youth Sports And Mental Health, Tara Boer

Faculty Work Comprehensive List

"Ultimately, athletes should be encouraged to develop their identity holistically. They are athletes, but they are first and foremost children of the King."

Posting about protecting mental health while participating in sports from In All Things, an online hub that offers insight into maintaining and faithful and orthodox Reformed Christian worldview while fearlessly engaging in every aspect of contemporary life – until all is made new.

Shifting Focus

The Echo: February 23, 2026, Taylor University

2025-2026 (Volume 113)

No abstract provided.

Experienced Nurses: Improving Retention By Implementation Strategies Found In Research And Those Applied In Practice, Hemilla Raju Matta

Creating Healthy Work Environments (CHWE)

Background & Purpose: The lack of literature focused on retention of experienced nurses reflects the need for more research in this area to help develop retention strategies and decrease turnover. Literature notes nurses want a safe work place, collegial relationships, supportive leadership and organization, and professional development. The purpose of this quality improvement project was to evaluate the effectiveness of a 12-week educational intervention aimed at professional development.

Methods: The quality improvement project was implemented at a community teaching medical center with outpatient services, located on the east coast post IRB approval. A pre/post educational interventional design method …

Q&A With Filmmaker Antonio Tarrell On 'Cole: Bridge To Justice', Clara Turnage

University of Mississippi News

OXFORD, Miss. – Antonio Tarrell is a Mississippi filmmaker who recently co-directed "Cole: Bridge to Justice," a documentary on the life and legacy of University of Mississippi icon Donald Ray Cole.

Synergistic Effect Of Different Ions And Hexadecyltrimethylammonium Bromide On Wettability Alteration For Carbonate Rock, Rafal S. Abdullah, Hussein Q. Hussein, Rana R. Jali

Baghdad Science Journal

Naturally carbonate reservoirs have very low oil recovery efficiency owing to their wettability and tightness of matrix. However, adding surfactant to brine solution can enhance oil recovery by changing the wettability of the carbonate rock surface from oil-wet to water-wet. In the present study, the effects of different brines in the presence of surfactant hexadecyltrimethylammonium bromide (CTAB), on the wettability of carbonate rock were investigated through different characteristics such as surface tension interfacial tension and contact angle. The best concentration of CTAB was investigated at 500 ppm in brine (NaCl) reduced surface tension and interfacial tensions to 42 mN/m and …

The Impact Of Vascular Endothelial Growth Factor, Neutrophil Gelatinase-Associated Lipocalin, And Interleukin-38 Food And Air Allergy Patients Following The Pandemic Of Covid-19 In Iraq, Esraa Hameed Khamees, Zaizafoon N. Nasif

Baghdad Science Journal

Allergies are a common health issue where the immune system reacts to substances in the environment that are normally harmless. This study further investigates the effects of vascular endothelial growth factor (VEGF), neutrophil gelatinase-associated lipocalin (NGAL), interleukin-38 (IL-38), immunoglobulin E (IgE), and the neutrophil-lymphocyte ratio (NLR) in these individuals, offering insight into the probable processes behind allergic responses following the pandemic. The study comprised 120 non-vaccinated females with previous COVID-19 infection. Groups included controls and food and air (F&A) allergic patients, with 60 individuals matched for age and gender. Serum levels of IL-38, VEGF, IgE, and NGLA were assessed using …

Best Friends, Jim Hannon/Staff

Documents

Kicking off National Pet Week with Miss UNA 1985, Alyssa Ashley, and her dog.

Freshman Wins Miss Una Title, Timesdaily

Documents

Bridgette DeLon Smith wins crown.

Cissy Ashley Commended By Alabama Legislature, East Lauderdale News

Documents

Miss UNA 1985 commended by the Alabama Legislature for her outstanding accomplishments.

Kitchens Chosen Miss Una, Itawamba County Times

Documents

Sondra Patrice Kitchens chosen as Miss UNA 1989.

The Secret Garden: Staff Caring For Staff, Erin Quinlan, Jennifer Schlebusch

Creating Healthy Work Environments (CHWE)

Healthcare workers provide for others in thoughtful, therapeutic ways, which becomes problematic if their mental and emotional resources are depleted. When healthcare workers experience a self-care deficit, their well-being and patient care are compromised. Recent factors contributing to staff stress include the impact of COVID-19 and the Pediatric Behavioral Health Crisis. An identified need to improve staff well-being was visible. The purpose of this quality improvement project, using the Plan-Do-Study-Act methodology, was to develop and implement the Secret Garden to improve the health of the work environment. The Secret Garden is a staff-only respite space, operationalized and managed to support …

Addressing Faculty Gaps In The Psychiatric Mental Health Nurse Practitioner Program, Shea Brock

Doctor of Nursing Practice Projects

Graduate nursing programs increasingly rely on adjunct faculty to sustain enrollment growth; however, inconsistent onboarding processes may contribute to variability in faculty preparedness and job satisfaction. The purpose of this quality improvement project was to implement a standardized adjunct faculty education program and evaluate its impact on adjunct faculty knowledge and job satisfaction within an online Psychiatric–Mental Health Nurse Practitioner (PMHNP) program. A quantitative, quasi-experimental one-group pre–post design was utilized. Six adjunct faculty members (n = 6) completed a 10-item EXXAT Knowledge Survey and a 10-item Faculty Satisfaction Survey before and after participation in a structured one-hour education session focused …

Breast Cancer Mortality In Memphis: A Holistic Approach - Research Findings And Strategies For Improved Outcomes In Segregated Communities, The Benjamin L. Hooks Institute For Social Change

The Hooks Institute Policy Papers

The Benjamin L. Hooks Institute for Social Change (Hooks Institute) is pleased to present its tenth edition of the policy papers, which focuses on breast health outcomes for women living in racially segregated commu-nities. The research that informed the articles in this publication, as well as this volume of the policy papers itself, was funded by a 2022 grant from the National Institutes of Health (NIH). The grant was awarded to a team of researchers that included Shelley White-Means, PhD (Principal Investigator); Arash Shaban-Nejad, MSc, MPH, PhD and Minghui Li, MSc, PhD (Co-Investigators) at University of Tennessee Health Science Cen-ter …

Examining Crime Trajectories At Micro Geographic Locations Across Varied Urban Contexts In The U.S., Xiaoshuang Iris Luo

University Research

Objectives

There is a lack of research for the spatial distribution of crime at micro geographic units across a variety of places. To address the research gap, this study examines crime trajectories over the most recent decade across a wide range of cities in the U.S.

Methods

Using cities of different sizes, developmental stages, and employment levels as the three criteria, official crime data from 12 U.S. cities between 2010 and 2018 are analyzed to examine crime trajectories at the street segment level. Group-based trajectory models are used to determine the distinct longitudinal trajectory profiles of violent crime and property …

Population Satisfaction Indicators Of The Quality-Of-Life Standards During The Work Trip (A Case Study Of The Cities Of Minia And New Minia), Shimaa Mohammed Hamdy Derbala, Amna Waz Amgad Ali

Mansoura Engineering Journal

The research examined the indicators of population satisfaction with the quality of life during work trips in the cities of Minia and New Minia, in relation to the problem of low urban communication between the two cities and the continued dependence of debtors on each other to provide employment opportunities. The research examined previous studies linking the quality of life of work trips to the environmental, social and psychological aspects of the movement and economy, A questionnaire was designed for a sample of the population (388 individuals) to assess the residents' impression of the quality of life during their work …

Improving Rural Health Through Nutrition Incentives: A Mixed Methods Evaluation Of The First Year Of The Appalachian Farmacy Program, Bethesda O'Connell, Harrison Ihrig, Andrea D Nutsugah, Ignacio Garcia, Michael Rice, Ashley Cavender

Journal of Social, Behavioral, and Health Sciences

Food insecurity remains a critical public health concern, particularly in rural, low-income communities. In 2023, 13.5% of United States households experienced food insecurity, with rates in Tennessee (15.6%) exceeding the national average. Produce prescription programs have emerged as a strategy to improve food access and promote healthier eating behaviors. This study presents an evaluation of Appalachian Farmacy, a produce prescription program in Northeast Tennessee designed to increase fruit and vegetable consumption among individuals receiving Medicaid, Medicare, or Supplemental Nutrition Assistance Program (SNAP) benefits. Program evaluation methods included semi-structured interviews for process evaluation and pre- and post-surveys for outcome evaluation. Interviews …