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Articles 40741 - 40770 of 2913381
Full-Text Articles in Entire DC Network
City Of Reno V. Dist. Ct. (Conrad) (Civil) [State Of Nevada], 142 Nev. Adv. Op. 13 (Feb. 26, 2026), Nathan Mackay
City Of Reno V. Dist. Ct. (Conrad) (Civil) [State Of Nevada], 142 Nev. Adv. Op. 13 (Feb. 26, 2026), Nathan Mackay
Nevada Supreme Court Summaries
Before issuing an ex parte writ of mandamus, a district court must address why regular inter partes procedure is inadequate. A district court that does not consider whether ex parte practice is appropriate abuses its discretion in issuing the writ.
An Exploratory Study Of Employability, Work Readiness, And International Experiences For One-Year International Postgraduate Taught Business Students In The Uk, Fa Wang
Plymouth Business School Theses
Delivering world-class student experiences, navigating evidence-based graduate outcomes, and advancing the employability agenda are central to the current landscape of UK universities. While maintaining high educational standards and remaining competitive in international student recruitment have become increasingly challenging after the global pandemic and amid ongoing financial pressures faced by the UK universities, limited academic attention has been given to the employability of one-year international postgraduate taught students (IPGTs) in UK higher education. Recognising IPGTs as a significant cohort that makes substantial economic, sociocultural, and expertise-related contributions to both tertiary education and the host country’s labour market, this doctoral study aims …
A Comparative Assessment Of School Psychological Services In A Select Higher Education Institution, Alvin Ryan Alcantara Dizon
A Comparative Assessment Of School Psychological Services In A Select Higher Education Institution, Alvin Ryan Alcantara Dizon
Makara Human Behavior Studies in Asia
This quantitative descriptive-comparative research assessed the effectiveness and adequacy of SPS in a higher education institution in Southern Tagalog, Philippines. This study aimed to identify the perceived importance of both direct and indirect psychological services and evaluate the extent of administrative support in implementing them. Participants included 75 administrative personnel, 30 mental health staff, and 384 faculty and student respondents selected through stratified proportional sampling. Data were collected using a validated and reliable instrument (Cronbach’s alpha = 0.966-0.989) and analyzed using analysis of variance and independent sample t-tests. Results revealed that all respondent groups rated direct services as very important …
Marital Satisfaction And Social Media Use: A Comparative Study Based On Addiction Levels, Fatma Ayhan, Elif Arık, Merve Gülsüm Saçan, Zehra Sevim, Esme Arguç
Marital Satisfaction And Social Media Use: A Comparative Study Based On Addiction Levels, Fatma Ayhan, Elif Arık, Merve Gülsüm Saçan, Zehra Sevim, Esme Arguç
Makara Human Behavior Studies in Asia
In recent years, the widespread use of social media platforms has raised questions about their impact on marital relationships. This study examined the relationship between marital satisfaction, social media use, and certain sociodemographic characteristics. This descriptive and cross-sectional study comprised 461 individuals residing in Turkey who had been married for at least one year. Data were collected using the Bergen Social Media Addiction and Marital Satisfaction Scales. Statistical analyses included t-tests, analysis of variance, and multiple linear regression analysis. Social media addiction was high among 16.5% of the participants. Marital satisfaction was higher among males, those who married at age …
Quaker Campus, February 26, 2026 (Vol. 24, Issue 9), Whittier College
Quaker Campus, February 26, 2026 (Vol. 24, Issue 9), Whittier College
Quaker Campus
No abstract provided.
Kenyon Collegian - February 26, 2026
February 26, 2026, The Daily Mississippian
February 26, 2026, The Daily Mississippian
Daily Mississippian (all digitized issues)
No abstract provided.
The Contribution Of Local Wisdom In The Nagasasra Textbook As Support For The Pancasila Student Profile Strengthening Project (P5), Nurhidayati Nurhidayati, Suwarna Suwarna, Sri Hertanti Wulan, Nujumun Niswah, Laura Zarbaliyeva
The Contribution Of Local Wisdom In The Nagasasra Textbook As Support For The Pancasila Student Profile Strengthening Project (P5), Nurhidayati Nurhidayati, Suwarna Suwarna, Sri Hertanti Wulan, Nujumun Niswah, Laura Zarbaliyeva
Bahasa dan Seni: Jurnal Bahasa, Sastra, Seni, dan Pengajarannya
The Merdeka Curriculum places strong emphasis on students' character development, which is operationalized through the Pancasila Student Profile Strengthening Project (P5) comprising six core dimensions. As one of the primary curricular resources, textbooks are expected to reflect and mediate these character values in classroom learning. This study aims to examine the contribution of Javanese local wisdom represented in the Nagasasra textbook to supporting the implementation of P5. Employing a qualitative descriptive design, this research adopts a document-based analysis of the Nagasasra Javanese language textbooks for grades X, XI, and XII. Data were collected using a read-and-record technique and analyzed through …
Advances In Real-Time American Sign Language Recognition System Using Deep Learning Techniques For Enhanced Accessibility, Bader Alsharif
Advances In Real-Time American Sign Language Recognition System Using Deep Learning Techniques For Enhanced Accessibility, Bader Alsharif
Electronic Theses and Dissertations 2020 - Present
Advancements in technology have significantly contributed to the development of innovative tools aimed at improving communication and accessibility for individuals with hearing impairments. This dissertation explores various machine learning and deep learning techniques for recognizing American Sign Language (ASL) gestures, focusing on enhancing accessibility and bridging the communication gap between hearing-impaired and hearing individuals. Traditional machine learning models, such as Random Forest, Support Vector Machines (SVM), and K-Nearest Neighbors (KNN), alongside deep learning architectures like AlexNet, ResNet-50, EfficientNet, ConvNeXt, and VisionTransformer, were investigated for their effectiveness. Experiments conducted on an extensive dataset of 87,000 ASL gesture images revealed exceptional recognition …
Machine Learning For Elderly Behavior And Risk Incident Modeling, Muhammad Tanveer Jan
Machine Learning For Elderly Behavior And Risk Incident Modeling, Muhammad Tanveer Jan
Electronic Theses and Dissertations 2020 - Present
The rapid expansion of the aging population presents critical challenges to healthcare systems, particularly in maintaining independent living, ensuring mobility safety, and optimizing emergency interventions. Traditional monitoring solutions are often fragmented, reactive, and hindered by the scarcity of data regarding rare high-risk events. This dissertation proposes a comprehensive, multi-modal machine learning framework designed to model elderly behavior and predict risk incidents across three critical environments: the home, the vehicle, and the clinical setting.
To address the fundamental challenge of class imbalance in medical and behavioral datasets—where risk events are statistically rare—this research first introduces a dual-phase data augmentation strategy. By …
Gastric Volvulus As A Rare Sequelae Of A Hiatal Hernia: A Case Report And Review Of The Literature, George Ladas, Jake Wiepen, Christopher Stewart, Mitchell Fisher, Suporn Sukpraprut-Braaten, Charles Harper
Gastric Volvulus As A Rare Sequelae Of A Hiatal Hernia: A Case Report And Review Of The Literature, George Ladas, Jake Wiepen, Christopher Stewart, Mitchell Fisher, Suporn Sukpraprut-Braaten, Charles Harper
Student Publications
Gastric volvulus is a rare but potentially life-threatening complication of a hiatal hernia that can result in gastric ischemia or necrosis if not promptly recognized and treated. A 51-year-old man presented with several hours of severe nausea, vomiting, and chest pain. Physical examination was notable for signs of acute distress, and the patient reported dark-colored emesis. Initial laboratory evaluation demonstrated leukocytosis and elevated serum lactate levels. Computed tomography of the chest and abdomen revealed a large hiatal hernia with herniation of the majority of the stomach into the thoracic cavity and findings concerning for mesoaxial gastric volvulus. Esophagogastroduodenoscopy demonstrated ischemic …
An Interoperable Vaccine Record: A Roadmap To Realization, Xia Jing, Arild Faxvaag, Christian G Nøhr, David Robinson, Paul G Biondich, Timothy D Law, Hua Min, Adam Wright, Yang Gong, Dean F Sittig
An Interoperable Vaccine Record: A Roadmap To Realization, Xia Jing, Arild Faxvaag, Christian G Nøhr, David Robinson, Paul G Biondich, Timothy D Law, Hua Min, Adam Wright, Yang Gong, Dean F Sittig
Faculty, Staff and Student Publications
Objectives: The objectives of this study were to educate the healthcare professional and the general public about interoperable vaccine records by elaborating on its definition, why we need one, what the challenges are, and what progress has been made in this direction.
Methods: The vaccination practices and vaccine record-keeping in the Nordic countries, the UK, and the USA are used as examples to demonstrate the necessity of interoperable vaccine records. The authors' expertise and experience in interoperability, medicine, and HealthIT, along with the literature, informed this paper's content, structure, and organization. Real-world examples and scenarios illustrate the reality …
Making Sense Of And Responding To The Good And Bad Within Psychology: Common Grace And Antithesis As Tools For Psychology, Tyler Greenway, Cory B. Wilson
Making Sense Of And Responding To The Good And Bad Within Psychology: Common Grace And Antithesis As Tools For Psychology, Tyler Greenway, Cory B. Wilson
University Faculty Publications and Creative Works
As psychologists and students of psychology make sense of and respond to the good and bad within human behavior and its study, theological tools benefit their discernment. This paper presents two Neocalvinist theological concepts — common grace and antithesis — as tools for psychologists. These concepts help psychologists recognize God’s common gifts to humanity while also identifying what must be corrected. Such applications benefit psychologists in clinical cases and as they consider theoretical frameworks. When used together, these tools encourage us to anticipate both the true, good, and beautiful things in the world and the need at times for redirection. …
What Every Economist Should Know About Energy, Matthew Kuperus Heun
What Every Economist Should Know About Energy, Matthew Kuperus Heun
University Faculty Publications and Creative Works
Presentation to students in Political Economy of the Environment UMass Amherst Thur, 26 February 2026
February 26, 2026, James Madison University
February 26, 2026, James Madison University
The Breeze, 2020-
The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.
How Fhsu's Ethic Of Care Is Transforming Kansas, February 26, 2026, Tisa Mason Ed.D.
How Fhsu's Ethic Of Care Is Transforming Kansas, February 26, 2026, Tisa Mason Ed.D.
Heart of a Tiger Columns
No abstract provided.
Computational Repurposing And Experimental Validation Of Ybx1 Inhibitors In Hepatocellular Carcinoma, Omar Karkoutly, Veerababu Nagati, Subhash Chauhan, Manish Tripathi
Computational Repurposing And Experimental Validation Of Ybx1 Inhibitors In Hepatocellular Carcinoma, Omar Karkoutly, Veerababu Nagati, Subhash Chauhan, Manish Tripathi
School of Medicine Publications
Background/Objectives: Hepatocellular carcinoma (HCC) is the most common type of liver cancer worldwide. While early-stage HCC can often be treated with surgical resection, ablation, or liver transplantation, advanced disease typically relies on systemic chemotherapy. Sorafenib is the standard first-line therapy for advanced and unresectable HCC; however, both intrinsic and acquired resistance remain major clinical challenges. The Y-box binding protein-1 (YBX1), a transcription factor implicated in drug resistance across multiple cancers, is highly expressed in HCC and represents a potential therapeutic target. This study aimed to identify novel YBX1 inhibitors using a drug repurposing strategy to overcome sorafenib resistance. Methods: A …
Pest Management For Utah Cut Flower Production: Insects And Their Relatives, Nick Volesky, Marion Murray, Melanie Stock
Pest Management For Utah Cut Flower Production: Insects And Their Relatives, Nick Volesky, Marion Murray, Melanie Stock
All Current Publications
Pest management is important in cut flower production, marketability, and farm profitability. This fact sheet focuses on animal pests (insects, arthropods, mollusks, and vertebrates), not diseases or weeds, and has two parts. Part 1 applies Integrated Pest Management (IPM): using preventive techniques, pest thresholds, and best management practices with pests in cut flower crop production. Part 2 highlights the top 10 common pests of cut flowers in Utah and their management.
High Frequency Emergency Department Use And Heterogeneity Of Reasons For Attendance By Children And Young People: A Retrospective Cohort Study, Akshay Kumar, Rebecca M Simpson, Kerryn Husk, Graham D Johnson, Chris Burton
High Frequency Emergency Department Use And Heterogeneity Of Reasons For Attendance By Children And Young People: A Retrospective Cohort Study, Akshay Kumar, Rebecca M Simpson, Kerryn Husk, Graham D Johnson, Chris Burton
Peninsula Medical School
Objective To quantify patterns of emergency department (ED) use over two consecutive 12-month periods among children aged 15 and under, and to assess heterogeneity of reasons for attendance in high-frequency users.Design Population-based retrospective cohort study of routinely collected ED data.Setting EDs in the Yorkshire and Humber region, UK, from 31 March 2014 to 1 April 2017.Patients Children aged 15 and under with ≥1 ED attendance.Main outcome measures Proportion with ≥7 attendances over 2 years and heterogeneity of diagnostic reasons quantified by the Herfindahl index.Results The cohort included 71 143 individuals. Although only 13.6% were high-frequency attenders in the first year, …
Family Imprint Reveals Basin-Wide Patterns Of Amazon Forest Embolism Resistance, Julia Valentim Tavares, Emanuel Gloor, Thiago S.F. Silva, Rafael S. Oliveira, Fernanda Coelho De Souza, Caroline Signori-Müller, Francisco Carvalho Diniz, Luciano Pereira, Martin Acosta, Martin Gilpin, Manuel J. Marca Zevallos, Carlos A. Salas Yupayccana, Flor M. Perez-Mullisaca, Halina Jancoski, Marina Corrêa Scalon, Beatriz Schwantes Marimon, Ben Hur Marimon Junior, Yadvinder Malhi, Imma Oliveras Menor, Lucy Rowland, Patrick Meir, Paulo Bittencourt, Antonio Carlos Lola Da Costa, João Antônio R. Santos, Renata Teixeira De Oliveira, Adriane Esquivel-Muelbert, Esteban Álvarez-Dávila, Miguel N. Alexiades, Edmar Almeida De Oliveira, Ana Andrade
Family Imprint Reveals Basin-Wide Patterns Of Amazon Forest Embolism Resistance, Julia Valentim Tavares, Emanuel Gloor, Thiago S.F. Silva, Rafael S. Oliveira, Fernanda Coelho De Souza, Caroline Signori-Müller, Francisco Carvalho Diniz, Luciano Pereira, Martin Acosta, Martin Gilpin, Manuel J. Marca Zevallos, Carlos A. Salas Yupayccana, Flor M. Perez-Mullisaca, Halina Jancoski, Marina Corrêa Scalon, Beatriz Schwantes Marimon, Ben Hur Marimon Junior, Yadvinder Malhi, Imma Oliveras Menor, Lucy Rowland, Patrick Meir, Paulo Bittencourt, Antonio Carlos Lola Da Costa, João Antônio R. Santos, Renata Teixeira De Oliveira, Adriane Esquivel-Muelbert, Esteban Álvarez-Dávila, Miguel N. Alexiades, Edmar Almeida De Oliveira, Ana Andrade
School of Geography, Earth and Environmental Sciences
Amazon rainforests face intensifying water stress due to increases in vapour pressure deficit and changing hydrological regimes. Embolism resistance (Ψ50) is a critical metric of tree survival under drought conditions, it is defined as a plant’s capacity to resist disruption of xylem water flow due to air bubble formation from water stress. However, measurements of Ψ50 are only available for a limited number of Amazon locations and species. Conversely, data on forest taxonomic composition are abundant across Amazonia, and if Ψ50 is conserved phylogenetically, these data could provide a way to scale-up drought resistance patterns. Here …
Meeting The Challenge Of Civic Education In Hyperpolarized Times, Linda C. Mcclain
Meeting The Challenge Of Civic Education In Hyperpolarized Times, Linda C. Mcclain
Faculty Scholarship
What role can civic education play in polarized times? That is the pressing question posed by Civic Education in Polarized Times, edited by Elizabeth Beaumont and Eric Beerbohm.1 As Beaumont’s introduction explains, “as political polarization has intensified across the world, civic education seems more urgent, but it has also become more challenging.” (P. 1.) The volume brings together an eminent group of education scholars, legal scholars, political theorists, and philosophers to consider challenging questions about how to carry out civic education “in a polarized era” and “for a polarized era.” (P. 2.)
Amicus Brief In Trump V. Barbara: An Originalist Defense Of Birthright Citizenship, Jed Handelsman Shugerman, Evan D. Bernick
Amicus Brief In Trump V. Barbara: An Originalist Defense Of Birthright Citizenship, Jed Handelsman Shugerman, Evan D. Bernick
Faculty Scholarship
For nearly all of the first 235 years under the Constitution, the citizenship of every child born in the United States to alien parents, with immaterial exceptions, was a given. Then, in 2025, the Trump administration changed course. Even though the Fourteenth Amendment makes no mention of limiting birthright citizenship to the children of domiciled parents, the Government now claims that is what “subject to the jurisdiction thereof” has always meant. While the Government and its amici admit that the common law recognized the citizenship of children of transient aliens, their remaining “survey of history range[s] from the constitutionally irrelevant” …
Hiv Infection, Neurotoxicity, Inflammation, Premature Aging, And Therapeutic Challenges To Plwh: An Overview, Mudit Tyagi, Ulhas P. Naik, Kratika Tyagi, Madhulika Sharma, Gagan Kaushal, Alok Bhushan, Michael Bukrinsky, Priya Tyagi
Hiv Infection, Neurotoxicity, Inflammation, Premature Aging, And Therapeutic Challenges To Plwh: An Overview, Mudit Tyagi, Ulhas P. Naik, Kratika Tyagi, Madhulika Sharma, Gagan Kaushal, Alok Bhushan, Michael Bukrinsky, Priya Tyagi
Department of Medicine Faculty Papers
HIV infection remains a major global health challenge due to its complex pathogenesis and lifelong persistence in people living with HIV (PLWH). A central barrier to eradication is the virus's ability to establish long-lived latent reservoirs in different tissues, including the central nervous system (CNS), where it evades immune clearance and antiretroviral therapy (ART). These reservoirs, seeded early during infection, fuel viral rebound if ART is interrupted, requiring lifelong treatment. In the CNS, HIV persists despite systemic viral suppression because of limited ART penetration across the blood-brain barrier (BBB), and infection of long-lived cells such as microglia and perivascular macrophages. …
Recognizing Structural And Social Determinants Of Health In The Diagnosis And Care Of Dementia, Shana D Stites, Sharnita Midgett, Nisha Patel, Kimberly Halberstadter, Rosalie Schumann, Marissa L Streitz, Yidan Shi, John C Morris, Jason Flatt, Crystal M Glover, Dawn Mechanic-Hamilton
Recognizing Structural And Social Determinants Of Health In The Diagnosis And Care Of Dementia, Shana D Stites, Sharnita Midgett, Nisha Patel, Kimberly Halberstadter, Rosalie Schumann, Marissa L Streitz, Yidan Shi, John C Morris, Jason Flatt, Crystal M Glover, Dawn Mechanic-Hamilton
2020-Current year OA Pubs
Structural and social determinants of health are environmental conditions that affect individuals' health and functioning across the life course. These determinants are salient factors at the apex of individual psychology, community variables, and larger sociological factors, exerting prominent effects on individuals' wellbeing. The National Institute on Aging seeks to understand their influence on aging and Alzheimer's disease. We propose that the benefits of doing so may reach beyond knowledge of disease mechanisms - it may also improve clinical outcomes. We describe efforts introducing structural and social determinants of health data into the national network of Alzheimer's disease research centers. We …
Bl(U)E Crab: Bluetooth Low Energy Connection Risk Assessment Benchmarking, Dylan Christopher Conklin
Bl(U)E Crab: Bluetooth Low Energy Connection Risk Assessment Benchmarking, Dylan Christopher Conklin
Dissertations and Theses
The usage of Bluetooth Low Energy (BLE)-based tracker devices for stalking has become a salient privacy concern. Detecting unwanted or suspicious trackers is challenging due to their cross-platform compatibility issues, inconsistent detection methods, and lack of an industry-wide standard for detecting malicious devices. BL(u)E CRAB, Bluetooth Low Energy Connection Risk Assessment Benchmarking, scans data and generates risk factors about nearby devices to classify them as suspicious or not. These risk factors include the number of encounters the user had with a device, the duration of time a device has been near the user, the distance a device has traveled …
Merritt-Putnam Symposium | Tumor-Associated Epilepsy And Epilepsy-Associated Tumors: Exploring The Bidirectional Crosstalk Between Tumors And Seizures, Tracy A Bedrosian, Michael Wong, Erin L Heinzen, Benjamin Deneen, Catherine A Christian-Hinman
Merritt-Putnam Symposium | Tumor-Associated Epilepsy And Epilepsy-Associated Tumors: Exploring The Bidirectional Crosstalk Between Tumors And Seizures, Tracy A Bedrosian, Michael Wong, Erin L Heinzen, Benjamin Deneen, Catherine A Christian-Hinman
Faculty, Staff and Students Publications
Links between cancerous and noncancerous brain tumors and epilepsy have long been recognized. However, recent clinical and preclinical studies emphasize that not only do tumors impinge on surrounding brain tissue in ways that promote hyperexcitability and epileptogenesis, but that neural activity also influences tumor progression. In this review, inspired by the Merritt-Putnam Symposium of the 2025 meeting of the American Epilepsy Society, we present a cross-disciplinary dialog between cancer and epilepsy research, including discussion of tumors and epilepsies that are more prominent in pediatric versus adult populations. First, we discuss the neuropathology, genetics, and surgical outcomes of epileptogenic brain tumors, …
Frequency And Self-Reported Outcomes Of Transcranial Magnetic Stimulation For Obsessive Compulsive Disorder In The U.S. And Latin America, Hala Aziz, Guadalupe Vidal-Martinez, Ogechi C Onyeka, Jacey L Anderberg, Javier Vargas-Medrano, Diana Sotelo, Demi Kourtesi, Renee M Frederick, Josselyn S Muñoz, Dayan Berrones, Vanessa Zavala Cruz, Peter Thompson, Silvina Tonarelli, Andrew D Wiese, James J Crowley, Eric A Storch
Frequency And Self-Reported Outcomes Of Transcranial Magnetic Stimulation For Obsessive Compulsive Disorder In The U.S. And Latin America, Hala Aziz, Guadalupe Vidal-Martinez, Ogechi C Onyeka, Jacey L Anderberg, Javier Vargas-Medrano, Diana Sotelo, Demi Kourtesi, Renee M Frederick, Josselyn S Muñoz, Dayan Berrones, Vanessa Zavala Cruz, Peter Thompson, Silvina Tonarelli, Andrew D Wiese, James J Crowley, Eric A Storch
Faculty, Staff and Students Publications
Introduction: Obsessive compulsive disorder (OCD) affects about 1-2% of the global population, with roughly 30% of patients not responding to first-line treatments. Transcranial Magnetic Stimulation (TMS) has some support for treatment-resistant OCD but global use is unclear.
Methods: This study describes the frequency with which TMS was reported to be received among a large cohort of individuals who self-identified as Latino-Hispanic in Latin America and the United States. Among 3,391 participants, 76 (2.2%) had completed TMS for OCD.
Results: Recipients who received TMS exhibited more severe current and lifetime OCD symptoms compared to non-recipients. On average, participants underwent 22.61 TMS …
Somatic Genetic Rescue In Zcchc8-Associated Telomere Biology Disorders, Sophie De Tocqueville, Flavia Donaires, Nicholas Decleene, Ibrahima Ba, Mina Nouri, Laëtitia Kermasson, Malika Chelbi, Emmanuel Bergot, Thierry Leblanc, Raphael Borie, Quentin Philippot, Elise Antone, Grégoire Prévot, Elodie Blanchard, Boris Keren, Elodie Lainey, Marilia Catto, Barbara Santana, Settara C Chandrasekharappa, Frank X Donovan, Luiz Fernando Bazzo Catto, Isabelle Callebaut, Neal S Young, Carine Halfon-Domenech, Rodrigo T Calado, Alison A Bertuch, Fernanda Gutierrez-Rodrigues, Caroline Kannengiesser, Patrick Revy
Somatic Genetic Rescue In Zcchc8-Associated Telomere Biology Disorders, Sophie De Tocqueville, Flavia Donaires, Nicholas Decleene, Ibrahima Ba, Mina Nouri, Laëtitia Kermasson, Malika Chelbi, Emmanuel Bergot, Thierry Leblanc, Raphael Borie, Quentin Philippot, Elise Antone, Grégoire Prévot, Elodie Blanchard, Boris Keren, Elodie Lainey, Marilia Catto, Barbara Santana, Settara C Chandrasekharappa, Frank X Donovan, Luiz Fernando Bazzo Catto, Isabelle Callebaut, Neal S Young, Carine Halfon-Domenech, Rodrigo T Calado, Alison A Bertuch, Fernanda Gutierrez-Rodrigues, Caroline Kannengiesser, Patrick Revy
Faculty, Staff and Students Publications
We show that somatic genetic rescue is frequent in telomere biology disorders (TBDs) caused by germ line ZCCHC8 variants. Our results highlight the critical intrinsic role of ZCCHC8 in human hematopoiesis and a potential mechanism for disease modification in TBDs.
Coordinated Stimulation Of Axon Regenerative And Neurodegenerative Transcriptional Programs By Atf4 Following Optic Nerve Injury, Preethi Somasundaram, Madeline M Farley, Melissa A Rudy, Katya Sigal, Andoni I Asencor, David G Stefanoff, Malay Shah, Puneetha Goli, Jenny Heo, Shufang Wang, Nicholas M Tran, Trent A Watkins
Coordinated Stimulation Of Axon Regenerative And Neurodegenerative Transcriptional Programs By Atf4 Following Optic Nerve Injury, Preethi Somasundaram, Madeline M Farley, Melissa A Rudy, Katya Sigal, Andoni I Asencor, David G Stefanoff, Malay Shah, Puneetha Goli, Jenny Heo, Shufang Wang, Nicholas M Tran, Trent A Watkins
Faculty, Staff and Students Publications
Stress signaling is important for determining the fates of neurons following axonal insults. Previously, we showed that the stress-responsive kinase PERK contributes to injury-induced neurodegeneration (Larhammar et al., 2017). Here, we show that PERK acts primarily through activating transcription factor-4 (ATF4) to stimulate not only pro-apoptotic but also pro-regenerative responses following optic nerve damage. Using conditional knockout mice, we find an extensive PERK/ATF4-dependent transcriptional response that includes canonical ATF4 target genes and modest contributions by C/EBP Homologous Protein (CHOP). Overlap with c-Jun-dependent transcription suggests interplay with a parallel stress pathway that orchestrates regenerative and apoptotic responses. Accordingly, neuronal knockout of …
Preferred Panethnic Terms Among Latina/O And Hispanic Sexual And Gender Minority People, Alexis Ceja, Nguyen K. Tran, Juan M. Peña, David J. Kinitz, Devin Hursey, Ramon Ramirez, Lilia Cervantes, Micah E. Lubensky, Juno Obedin-Maliver, Annesa Flentje, Mitchell R. Lunn
Preferred Panethnic Terms Among Latina/O And Hispanic Sexual And Gender Minority People, Alexis Ceja, Nguyen K. Tran, Juan M. Peña, David J. Kinitz, Devin Hursey, Ramon Ramirez, Lilia Cervantes, Micah E. Lubensky, Juno Obedin-Maliver, Annesa Flentje, Mitchell R. Lunn
Faculty Research, Scholarly, and Creative Activity
Importance Latino and Hispanic individuals in the US represent a diverse and growing population, including a significant number of sexual and gender minority (SGM) individuals whose identities challenge the use of a single panethnic (ie, ethnicity) label. Little is known about SGM individuals’ preferences for panethnic terms. Objective To understand Latino and Hispanic SGM individuals’ preferences and rationales for panethnic terms. Design, Setting, and Participants This cross-sectional study used survey data from SGM-identifying Latino and Hispanic adults in The PRIDE Study, an online, community-engaged cohort of SGM adults in the US completing 2021 or 2022 annual questionnaires, with qualitative analysis …