Digital Commons Network^™

Of Vascular Defense, Hemostasis, Cancer, And Platelet Biology: An Evolutionary Perspective, David G Menter, Vahid Afshar-Kharghan, John Paul Shen, Stephanie L Martch, Anirban Maitra, Scott Kopetz, Kenneth V Honn, Anil K Sood

Faculty, Staff and Student Publications

We have established considerable expertise in studying the role of platelets in cancer biology. From this expertise, we were keen to recognize the numerous venous-, arterial-, microvascular-, and macrovascular thrombotic events and immunologic disorders are caused by severe, acute-respiratory-syndrome coronavirus 2 (SARS-CoV-2) infections. With this offering, we explore the evolutionary connections that place platelets at the center of hemostasis, immunity, and adaptive phylogeny. Coevolutionary changes have also occurred in vertebrate viruses and their vertebrate hosts that reflect their respective evolutionary interactions. As mammals adapted from aquatic to terrestrial life and the heavy blood loss associated with placentalization-based live birth, platelets …

Current State And Future Directions Of Genomic Medicine In Aortic Dissection: A Path To Prevention And Personalized Care, Alana C Cecchi, Madeline Drake, Chrisanne Campos, Jake Howitt, Jonathan Medina, Scott M Damrauer, Sherene Shalhub, Dianna M Milewicz, Aortic Dissection Collaborative

Faculty, Staff and Student Publications

Aortic dissection confers high mortality and morbidity rates despite advances in treatment, impacts quality of life, and contributes immense burden to the healthcare system globally. Efforts to prevent aortic dissection through screening and management of modifiable risk factors and early detection of aneurysms should incorporate genomic information, as it is integral to stratifying risk. However, effective integration of genomic-guided risk assessment into clinical practice will require addressing implementation barriers that currently permeate our healthcare systems. The Aortic Dissection Collaborative was established to define aortic dissection research priorities through patient engagement. Using a collaborative patient-centered feedback model, our Genomic Medicine Working …

The Epistemology Of Second Best, Gary S. Lawson

Faculty Scholarship

Second best theory “holds that where it is not possible to satisfy all the conditions necessary for a[] . . . system to reach an overall optimum, it is not generally desirable to satisfy as many of those conditions as possible.” Adrian Vermeule, Foreword: System Effects and the Constitution, 123 HARV. L. REV. 4, 17 (2009). In other words, if you are not moving all the way to the ideal state of affairs, it is unclear whether partial moves that seem to go in the direction of the ideal make the world “better” or “worse” – with “better” or “worse” …

Value Of Measurable Residual Disease Monitoring In Patients With Acute Promyelocytic Leukemia In The Era Of Frontline ‘Chemotherapy-Free’ Therapy, Jorge M Ramos Perez, Keyur P Patel, Sanam Loghavi, Guillermo Garcia-Manero, Gautam Borthakur, Elias Jabbour, William Wierda, Sherry Pierce, Mark Brandt, Steven Kornblau, Tapan Kadia, Naval Daver, Courtney D Dinardo, Nitin Jain, Musa Yilmaz, Nicholas Short, Srdan Verstovsek, Alessandra Ferrajoli, Michael Andreeff, Marina Konopleva, Daniel Rivera, David Mccue, Hagop M Kantarjian, Farhad Ravandi

Faculty, Staff and Student Publications

Acute promyelocytic leukemia (APL) is characterized by the chromosomal translocation t(15;17) and the resulting gene PML-RARA, used for measurable residual disease (MRD) monitoring. Despite highly effective therapy for APL, MRD monitoring practices are not fully established. We aimed to assess the value of MRD monitoring by RT-qPCR in patients with APL treated with ATRA and arsenic trioxide +/- GO. We reviewed 223 patients with APL treated with this regimen. RT-qPCR for PML-RARA was measured every 3 months, and at 12, 18, and 24 months after therapy. Seven patients relapsed. Time to relapse was 7.9-12.4 months in 6 patients, and …

Glutathione S-Transferase: A Candidate Gene For Berry Color In Muscadine Grapes (Vitis RotundifoliA), Aruna Varanasi, Margaret Worthington, Lacy Nelson, Autumn Brown, Thomas Mason Chizk, Renee Threlfall, Luke Howard, Patrick Conner, Rosa Figueroa-Balderas, Melanie Massonnet, Dario Cantu, John R. Clark

Horticulture Faculty Publications and Presentations

Muscadine grapes (Vitis rotundifolia Michx.) are a specialty crop cultivated in the southern United States. Muscadines (2n = 40) belong to the Muscadinia subgenus of Vitis, while other cultivated grape species belong to the subgenus Euvitis (2n = 38). The muscadine berry color locus was mapped to a 0.8 Mbp region syntenic with chromosome 4 of Vitis vinifera. In this study, we identified glutathione S-transferase4 as a likely candidate gene for anthocyanin transport within the berry color locus. PCR and Kompetitive allele-specific PCR genotyping identified a single intragenic SNP (C/T) marker corresponding to a proline …

Gender Gaps In Math Performance, Perceived Mathematical Ability And College Stem Education: The Role Of Parental Occupation, Lina Anaya, Frank P. Stafford, Gema Zamarro

Education Reform Faculty and Graduate Students Publications

Despite the promising future of employment opportunities in occupations related to Science, Technology, Engineering, and Mathematics (STEM), women remain underrepresented in some STEM occupational fields. We use data from the Panel Study of Income Dynamics to study the role of gender differences in achievement and self-perceived ability in math during childhood, along with parental occupation (science-related versus non-science-related jobs), in the subsequent decision of majoring in science in college. Our findings suggest a loss in STEM enrollment by otherwise qualified young women and highlight the potential importance of parental occupation in STEM in encouraging women's participation in certain STEM fields.

Tax Evasion And Fraud In The United States Sex Market, Youngbee Dale

Dignity: A Journal of Analysis of Exploitation and Violence

This study describes tax evasion or fraud in the United States sex market. Prior to this study, scholars have recognized the problem of tax evasion in the commercial sex market as an obstacle to national revenue collection. Tax violation and fraud investigations also are ways to combat the illegal commercial sex industry. However, no studies have focused on the problem in the United States sex market. Hence, this study aims to describe tax evasion or fraud methods used by the criminals operating in the United States sex market. This study relies on both quantitative and qualitative methods to examine the …

Prediction Of Bystander Intervention Behavior In A Sexual Assault Situation: The Role Of Religiosity, Empathy, And Gratitude, John D. Foubert, Mwarumba Mwavita, Kelva Hunger, Wei-Kang Kao, Pam Pittman-Adkins

Dignity: A Journal of Analysis of Exploitation and Violence

Bystander intervention in potential sexual assault situations is a common method of helping to address sexual violence on college campuses. Although numerous variables have been shown to mediate bystander intervention behavior, the pool of potential correlates is limited. The present study used regression analysis to determine the relationship between bystander behavior and three predictors: religiosity, gratitude, and victim empathy. Consistent with prior research, both religiosity and gratitude significantly predicted bystander behavior. Contrary to prior research, the relationship between victim empathy and bystander behavior was negative. Findings are discussed relating to potential bystander intervention programs, and future research, particularly on gratitude, …

Sexual Coercion, Unintended Pregnancy, And Poor Reproductive Health Among Adolescent Girls (Aged 13 - 19) In Mexico, Arun Kumar Acharya, Maria Luisa Martinez

Dignity: A Journal of Analysis of Exploitation and Violence

In Mexico, nearly 23,000 adolescents between the ages of 12-17 years suffer sexual coercion every year. This group also has a high birth rate of 77/1,000 adolescents, which indicates that one in every five pregnant women is an adolescent. This study describes the sexual coercion of victims and their views regarding the experience based on data collected from 37 Mexican girls between the age of 13 to 19, selected purposively using the snowball method in Monterrey city, Mexico. Results indicate that sexual coercion among adolescents is a serious problem, where 70% of adolescents experienced vaginal sexual coercion, nearly 22% experienced …

‘They Did Not Have To Burn My Sister Alive’: Causes And Distribution By State Of Dowry Murder In India, Peter Mayer

Dignity: A Journal of Analysis of Exploitation and Violence

Dowry, the money, goods, property, or gifts given by the bride’s family to the groom or his family at the time of marriage, is a common custom in South Asia. Although it is illegal to demand—or offer—a dowry in India, it is a nearly universal custom in many parts of the country. If, after marriage, a husband’s family feels that the wife’s dowry was insufficient, they may harass or inflict other forms of domestic violence on her to put pressure on her family to provide an additional dowry. At its most extreme, this violence may lead to the murder of …

Simultaneous Strength-Ductility Enhancement In As-Cast Ti6al4v Alloy By Trace Ce, K. M. Li, Y. J. Liu, X. C. Liu, X. Wu, S. F. Zhou, Laichang Zhang, W. Li, W. C. Zhang

Research outputs 2022 to 2026

Impurity elements always play a major role in hindering mechanical property improvement in Ti6Al4V, and specifically most of them e.g. O, P, Cl, and S dissolved in the matrix deteriorate the mechanical properties of Ti6Al4V. This work presents a strategy of enhancing the mechanical performance of as-cast Ti6Al4V alloy by adding a small amount of rare earth (i.e. 0.1 wt% Ce), where deleterious elements could be absorbed from the crystalline lattice during solidification process, forming uniformly distributed Ce-rich oxides or precipitates with ∼200 nm in size. The Ce-rich precipitates in turn refine the beta phase lamellae by introducing more nucleation …

Gatekeepers, Guides And Ghosts: Intermediaries Impacting Access To Schools During Covid-19, Michelle Striepe, Christine Cunningham

Research outputs 2022 to 2026

This article reflects on the effect of gatekeepers, guides and ghosts on gaining access to research participants and field sites. Using a critically reflective approach, we examine our role as researchers and the roles of intermediaries in the process to access schools during the COVID-19 pandemic. Our findings show how gaining access is a non-linear process that is influenced by the agency of researchers and intermediaries at different contextual levels. Our analysis probes past research on gatekeepers, develops the emerging research on the role of guides and advances current understandings by introducing the concept of ghosts. Given the lack of …

Taking Flight, Georgia Southern University

College of Business: News & Publications

• Taking Flight- March 2022
• Message from the Dean

Bc-Dunet-Based Segmentation Of Fine Cracks In Bridges Under A Complex Background, Tao Liu, Liangji Zhang, Guoxiong Zhou, Weiwei Cai, Chuang Cai, Liujun Li

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

Crack is the external expression form of potential safety risks in bridge construction. Currently, automatic detection and segmentation of bridge cracks remains the top priority of civil engineers. With the development of image segmentation techniques based on convolutional neural networks, new opportunities emerge in bridge crack detection. Traditional bridge crack detection methods are vulnerable to complex background and small cracks, which is difficult to achieve effective segmentation. This study presents a bridge crack segmentation method based on a densely connected U-Net network (BC-DUnet) with a background elimination module and cross-attention mechanism. First, a dense connected feature extraction model (DCFEM) integrating …

Spatiotemporal Analysis Of Urban Road Congestion During And Post Covid-19 Pandemic In Shanghai, China, Pengfei Xu, Weifeng Li, Xianbiao Hu, Hangbin Wu, Jian Li

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

Coronavirus Disease 2019 (COVID-19) has become one of the most serious global health crises in decades and tremendously influence the human mobility. Many residents changed their travel behavior during and after the pandemic, especially for a certain percentage of public transport users who chose to drive their owned vehicles. Thus, urban roadway congestion has been getting worse, and the spatiotemporal congestion patterns has changed significantly. Understanding spatiotemporal heterogeneity of urban roadway congestion during and post the pandemic is essential for mobility management. In this study, an analytical framework was proposed to investigate the spatiotemporal heterogeneity of urban roadway congestion in …

A Case Study Of Community-Engaged Design: Creating Parametric Insurance To Meet The Safety Needs Of Fisherfolk In The Caribbean, Daniel B. Oerther

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

The creation of the Caribbean Ocean and Aquaculture Sustainability faciliTy (COAST) is used as a case study of community-engaged design addressing safety needs. COAST is a parametric insurance product, sold to national governments, which was designed to meet the food and nutrition security of small- and medium-scale fisherfolk. The design of COAST is an example of convergence research, where the discipline of engineering was integrated with another discipline to solve pressing societal needs of Caribbean fisherfolk. This case study demonstrates that community-engaged design helps to (1) identify and include historically underrepresented stakeholders, (2) emphasize the importance of professional responsibility for …

The Correlation Of D-Dimer To Stroke Diagnosis Within 24 Hours: A Meta-Analysis, Adeel Ahmad, Zara Islam, Saad Manzoor Ahmad, Zouina Sarfraz, Azza Sarfraz, Miguel Felix, Ivan Cherrez-Ojeda

Department of Paediatrics and Child Health

Background: Diagnosing D-Dimer early is essential to optimize clinical treatment and quality of life and reduce mortality. This study aims to identify the difference of D-Dimer levels (ng/ml) in patients with stroke within the 6- and 24-h period compared to patients that mimic stroke.
Methods: An electronic database search across PubMed/MEDLINE, Cochrane, Web of Science, CINAHL, EMBASE, and Scopus was conducted until December 10, 2021. Studies were eligible if they included adult patients with stroke compared to stroke mimics or controls reporting D-Dimer values. Quality assessment was conducted using GRADE. The standardized mean difference and 95% confidence intervals were calculated …

Decoupling And Matching Network For Dual-Band Mimo Antennas, Min Li, Yujie Zhang, Di Wu, Kwan Lawrence Yeung, Lijun Jiang, Ross Murch

Electrical and Computer Engineering Faculty Research & Creative Works

This article presents a novel method to design the decoupling and matching network (DMN) for dual-band multi-input-multioutput (MIMO) antennas. The DMN consists of a grid of metallic microstrip stubs, some of which are connected while others are not. The connecting condition in the DMN is the only unknown variable for realizing high antenna isolation. It is determined by rigorous design formulas upon scattering matrix and optimized by the binary optimization algorithm, e.g., genetic algorithm (GA). Thus, high isolation among antennas can be achieved without requiring the optimization process in the electromagnetic simulation tool. Three decoupling examples of two two-element symmetric …

The Role Of Igg N-Galactosylation In Spondyloarthritis, Xiaojia Xu, Lois A. Balmer, Zhixian Chen, Gehendra Mahara, Ling Lin

Research outputs 2022 to 2026

Spondyloarthritis (SpA) is a group of chronic inflammatory arthritic diseases causing inflammatory back pain and stiffness, leading to irreversible damage of joint and spine, seriously affecting the quality of life. However, the exact pathogenesis of SpA is still unknown, although the blockers of tumor necrosis factor (TNF) are a major therapeutic advance. Of interest is the association between SpA and Immunoglobulin G (IgG) N-glycosylation. IgG N-glycosylation is a process of post-translational modification (PTM) that takes part in regulating anti- and pro-inflammatory effects. A relationship between IgG N-glycosylation and the development of inflammatory arthritic diseases exists, in addition …

Performance Improvement For Rural Hospitals: Front Line-Driven Change To Decrease Transfer Time From Ed To Inpatient Admission, Chasatie Whitley, Eddie Perez-Ruberte, Linda Kimsey, Bettye Apenteng

Center for Public Health Practice & Research

Highlights: A recent performance improvement project undertaken by a Georgia Critical Access Hospital (CAH) demonstrates the potential for use of Plan-Do-Study-Act (PDSA) techniques to improve operations in the area of patient transfers from Emergency Department (ED) to Inpatient Ward. Implemented process improvement, including visual tracking of inpatient hold in the ED and bedside handoff led to reductions in admission decision to ED departure time and delayed or omitted ED admission orders.

Background: The Georgia Southern Flex Team, funded by the Georgia State Office of Rural Health, assists the state’s CAHs in pursuing financial and operational excellence. Under an ongoing grant, …

Immunoanalytic Investigation Of Grain Proteins Antigenic For Celiac Disease Patients In An Einkorn Collection, Zsófia Birinyi, Dalma Réder, Ádám Diós, Ilma R. Korponay-Szabó, Éva Hunyadi-Gulyás, Christakis George Florides, Angéla Juhász, Gyöngyvér Gell

Research outputs 2022 to 2026

Our study focuses on the complex characterization of a wild and cultivated einkorn collection of the Cereal Gene Bank of Agriculture Research Institute in Hungary, using proteomics, immune analytics and bioinformatics analyses. In a serological ELISA pre-screen of 208 different Triticum monococcum L. ssp. monococcum and Triticum monococcum L. ssp. aegilopoides genotypes with celiac disease samples high diversity was observed in the immune response. Based on the immune analytic results, four genotypes with significantly reduced immune reactivity were selected for detailed proteomics characterization. Our results confirm the benefits of high-throughput/large-scale pre-screening and the use of a complex examination platform to …

Pcl-Peg Copolymer Based Injectable Thermosensitive Hydrogels, Mithun Rajendra Dethe, Prabakaran A, Hafiz Ahmed, Mukta Agrawal, Upal Roy, Amit Alexander

Health & Biomedical Sciences Faculty Publications

A number of stimuli-responsive-based hydrogels has been widely explored in biomedical applications in the last few decades because of their excellent biodegradability and biocompatibility. The development of synthetic chemistry and materials science leads to the emergence of in situ stimuli-responsive hydrogels. In this regard, several synthetic and natural polymers have been synthesized and utilized to prepare temperature-sensitive in situ forming hydrogels. This could be best used via injections as temperature stimulus could trigger in situ hydrogels gelation and swelling behaviors. There are many smart polymers available for the formulation of the in situ based thermoresponsive injectable hydrogel. Among these, poly …

The George-Anne Inkwell Edition, Georgia Southern University

The Inkwell

No abstract provided.

The George-Anne Daily, Georgia Southern University

George-Anne Media Group: Newsletters & Magazines

No abstract provided.

The Broken Fourth Amendment Oath, Laurent Sacharoff

Hofstra Law Faculty Scholarship

The Fourth Amendment requires that warrants be supported by "Oath or affirmation." Under current doctrine, a police officer may swear the oath to obtain a warrant merely by repeating the account of an informant. This Article shows, however, that the Fourth Amendment, as originally understood, required that the real accuser with personal knowledge swear the oath.

That real-accuser requirement persisted for nearly two centuries. Almost all federal courts and most state courts from 1850 to 1960 held that the oath, by its very nature, required a witness with personal knowledge. Only in 1960 did the Supreme Court hold in Jones …

High-Resistance Connection Diagnosis In Five-Phase Pmsms Based On The Method Of Magnetic Field Pendulous Oscillation And Symmetrical Components, Hao Chen, Jiangbiao He, Xing Guan, Nabeel Demerdash, Ayman M. El-Refaie, Christopher H.T. Lee

Electrical and Computer Engineering Faculty Research and Publications

An online approach for diagnosing high-resistance connection (HRC) faults in five-phase permanent magnet synchronous motor drives is presented in this article. The development of this approach is based on a so-called “magnetic field pendulous oscillation (MFPO)” technique and symmetrical components method. Under HRC fault condition, a “swing-like” MFPO phenomenon is observed compared to the healthy condition. Furthermore, with the extracted current features in symmetrical components domain, different HRC fault types are successfully identified and distinguished. These fault types include single-phase faults, e.g., HRC fault in phase-A; two-phase nonadjacent faults, e.g., HRC fault in phase-A&C; and two-phase adjacent faults, e.g., HRC …

Documenting An Open Future In A Post-Policy World, Caitlin Harrington, Rachel E. Scott

Faculty and Staff Publications – Milner Library

This session continues the work of a 2019 survey that investigated library policies related to Open Access (OA). Specifically, this study sought to address the self-selection of participants by randomly selecting and directly contacting academic librarians at libraries within one of four different Carnegie classifications to request input on their library’s collection development policies and the existence of OA policies or informal practices related to library collections. The findings surface disparities in the documentation of OA collection practices among institution classifications and highlight concerns about both OA and policies in the collections strategies of academic libraries.

Double The Vocation, Double The Awe: An Examination Of Vocational Awe In Music Librarianship, Z. Sylvia Yang, Emily Vickers

Library Faculty Publications

Building upon Ettarh’s call to dismantle vocational awe in librarianship, this article outlines the shared components of Western libraries and Western music that lay the groundwork for vocational awe in each of these institutions and explores the ways in which vocational awe uniquely manifests for workers in the interdisciplinary field of music librarianship. The article explores the narrative of music’s goodness, disciplinary training, and manifestations of vocational awe as they appear in the institutional cultures of practice of music and librarianship: inability to develop work-life balance, job creep, low morale, and inequitable compensation. In naming this phenomenon as it is …

“I Went Into This As One Person, And Then Came Out A Totally Different Person”: Native Lgbtq2s+ Young Adults’ Conceptions Of Trauma, Rachel M. Schmitz, Ruby Charak

Psychological Science Faculty Publications

Intersecting sources of stigma influence harmful mental health outcomes for lesbian, gay, bisexual, transgender, queer, and Two-Spirit (LGBTQ2S+) young adults (YA) of color as they must manage multiple oppressions. Experiencing both mental health challenges and victimization, LGBTQ2S+ YA of color struggle with distinctive psychological traumas. There is a critical need to determine how certain groups of LGBTQ2S+ YA of color’s marginalized social statuses shape trauma understandings. Native LGBTQ2S+ people in general endure diverse forms of oppression and trauma, such as histories of colonialism, contemporary racism, sexism, homophobia, and classism. Understanding the subjective interpretations of violence and trauma among Native LGBTQ2S+ …

Genetic Diversity Of Wild And Cultivated Muscadine Grapes (Vitis Rotundifolia Michx.), Kenneth Buck, Margaret Worthington

Horticulture Faculty Publications and Presentations

The muscadine (Vitis rotundifolia syn. Muscadinia rotundifolia) is an American grape species native to the southeastern United States that has been cultivated for centuries. Muscadines are one of three grape species in subgenus Muscadinia with a chromosome number of 2n = 40 (V. rotundifolia, Vitis munsoniana, and Vitis popenoei), making them genetically distinct from the European wine and table grape (Vitis vinifera) and other species in subgenus Euvitis. Crop improvement efforts have been continuous since the late 19th century, yet the germplasm that served as the foundation for early muscadine …