Digital Commons Network^™

A Study On The Early Stages Of Degradation Of Multi-Component Alloy Surfaces In Extreme Environments Using The Multi-Cell Monte Carlo Method, Tyler D. Dolezal

Theses and Dissertations

A computational toolset is presented and used in two examples that examined the interactions between structural materials and their extreme environments. A multi-cell Monte Carlo algorithm was developed to generate thermodynamically realistic solid-state alloy systems. These structures served as the foundation upon which surface slab models were generated. The tedious procedure of generating surface slab models from bulk structures was automated. The tools were used to study the high temperature surface corrosion resistance of a high-entropy alloy, Al₁₀Nb₁₅Ta₅Ti₃₀Zr₄₀, and a nickel-based alloy, Ni₇₀Nb₁₀W₂₀, under …

Characterization Of Environmental Conditioning Of Lithium Hydride Using Spectroscopy And Machine Learning, Ryan E. Pinson

Theses and Dissertations

Lithium compounds such as lithium hydride (LiH) and anhydrous lithium hydroxide (LiOH) have various applications in industry but are highly reactive when exposed to moisture and CO₂. These reactions create new molecular forms, including compounds such as lithium oxide (Li₂O), lithium hydroxide monohydrate (LiOH ·H₂O), and lithium carbonate (Li₂CO₃). These new compounds degrade the effectiveness in applications using these compounds. The negative effects induced by new lithium compounds creates a need for the ability to characterize the in-growth of such compounds. To study these in-growths, this work will present environmental …

Screening Heuristics For The Evaluation Of Covert Network Node Insertion Scenarios, Andrew E. Pekarek

Theses and Dissertations

The majority of research on covert networks uses social network analysis (SNA) to determine critical members of the network to either kill or capture for the purpose of network destabilization. This thesis takes the opposite approach and evaluates potential scenarios for inserting an agent into a covert network for information gathering purposes or future disruption operations. Due to the substantial number of potential insertion scenarios in a large network, this research proposes three screening heuristics that leverage SNA measures to reduce the solution space before applying a simple search heuristic.

A United States Air Force Site Selection Methodology In A Contested Agile Combat Employment Environment, Zachary T. Moer

Theses and Dissertations

The United States Air Force’s (USAF) Agile Combat Employment (ACE) strategy relies on host country access and underlying local infrastructure to facilitate airpower. However, numerous factors, including peer-to-peer threats, complex geopolitics, and intricate supply chain management, often complicate site access and thwart site selection decisions. When shaping the battlespace for future conflict, strategists and planners face the difficult task of identifying optimal locations to conduct adaptive basing operations given these complicating factors. Multi-Criteria Decision Analysis (MCDA) can help strategists appropriately account for competing objectives and maintain a competitive advantage with theater adversaries. This thesis presents an MCDA model that evaluates …

Examining Failures Of Kc-135s Using Survival Analysis, Vanessa I. R. Unseth

Theses and Dissertations

The United States Air Force manages an inventory of 396 KC-135 Stratotanker aircraft. With mission capability rates falling and total non-mission capability supply rates increasing, it is necessary to take a deeper look at recurrent failures. The study applies non-parametric and semi-parametric survival models to a dataset retrieved from LIMS-EV to look at the duration(s) until failure for the KC-135. Results of non-parametric models show cumulative failure rates increase as sorties or flight hours increase. In addition, semi-parametric models or Cox proportional hazards models with frailty confirm that locations or air bases are not associated with recurrent failures.

Burn Probability And Climate Change: A Quantitative Evaluation Of The Temporal Alterations Of Wildfire, David N. Robinson

Theses and Dissertations

The intensity of extreme weather events, specifically wildfires, along the West Coast has slowly grown overtime due to atmospheric changes caused by climate change. The Air Force, though aware of the threat that is wildfire, does not currently have a quantitative way to assess the hazard to base locations. In this paper, burn probability is quantitatively calculated through the geospatial analysis programs to provide a means of assessing wildfire vulnerability. The FlamMap fire simulator generated burn probabilities for Vandenberg Air Force Base using climate data generated by the remote automated weather station on the base to highlight how the burn …

Surrogate Modeling Of Computational Aerodynamic Responses For A Generic Hypersonic Vehicle, Jacob R. Johanik

Theses and Dissertations

In the field of multidisciplinary hypersonic vehicle design, striking the balance between the accuracy and efficiency of a predictive aerodynamic response model is a significant challenge. In response to this challenge, the objective of this thesis is to evaluate the aerodynamic performance of a Generic Hypersonic Vehicle (GHV) using the technique of surrogate modeling Computational Fluid Dynamic data points across a large range of flight conditions. To accomplish this, the full CFD process was conducted by preparing the vehicle geometry, generating a grid, computing the flow, and post-processing the data. A three-dimensional, quasi-random distribution of 1000 points defined the design …

Lockdowns As A War On The Poor: Looking At Outcomes In Silicon Valley, John B. Estill

Faculty Research, Scholarly, and Creative Activity

COVID-19 has led to unprecedented state-sponsored assaults on individual liberty including mask requirements, lockdowns, and mandatory testing and vaccinations. Unfortunately, these broad restrictions have multiple unintended consequences beyond the simple stripping away of individual rights. Silicon Valley, centered in Santa Clara County, represents a particularly compelling case. There has been much dialogue about the digital divide separating poor service workers from wealthy techies, and mandatory lockdowns have had a particularly damaging effect on the divide. They will continue to have negative ramifications long into the future.

Does Restoration Of Urban Riparian Zones Impact Stream Water Quality In Portland, Oregon, Ash Ivanov

University Honors Theses

Riparian zones influence urban stream quality through factors such as shading the stream, adding nutrients through leaf litter, stabilizing the stream banks to reduce turbidity, and filtering toxins out of the water. Riparian restoration often involves changing plant assemblage to be more diverse and include primarily native species instead of non-native, improving connection to the stream through changing stream morphology, improving species habitat, and reducing pollution. The goal of this study was to determine if urban riparian restoration projects in the region were successful, and if not, why that may be the case. The study was performed in the Portland, …

Exploring Stress Relief Methods And The Efficacy For The Houseless At Urban Settings, Lexis Bates

University Honors Theses

When the word "stress" is mentioned to lay people, they might think that their definitions of "stress" would be the same or similar. However, stress may vary by, not only degrees of the adverse circumstances, but also kinds of stressors which make an individual's experience of stress and their coping mechanisms complicated. Stress refers to a state of mental strain or tension resulting from adverse circumstances. Each individual living in society undergoes stress as a part of life. To some degree, stress keeps us motivated to stay alive in this way through survival instincts. However, excess stress may cause chaos …

Enhancing Exchange Of Knowledge On The Practice Of Applied Behavior Analysis, Harper C. Thomas

University Honors Theses

Applied behavior analysis (ABA) - originally a method of studying behavior - is now an intervention style that utilizes operant conditioning and behaviorism to teach and address behaviors that support the development of autistic students. While much of ABA is strongly supported by research, a debate exists over its use. Criticisms from people on the spectrum, their families, and professionals of various fields target everything from ABA’s implementation, research, and ethical basis. By clarifying what ABA entails, reviewing the history of ABA, compiling criticisms, and collecting opinions of Oregon-based behavioral specialists, this thesis seeks to identify regions where ABA can …

Child Success And Parental Marital Status: The Impact Of Mental Health, Poverty, And Trauma, Cambria Ort

University Honors Theses

Children are brought into this world under many different circumstances and to many different families. Some are planned, some are not; all come from families with a range of income, relationship status, and experiences. Throughout a child's life, there can be many changes in the family unit that impact the ways parents are available to care for their children. This includes divorce/separation, incarceration, co-parenting, married life, etc., relationship statuses may change over time. Different life stressors impact the financial wellbeing of a family and parents’ ability to spend time with their children. This study used secondary data analysis of the …

Perversion: A Genealogy Of Deviance And Creation Of The "Other", J D. Lyell

University Honors Theses

Drawing from Thomas Aquinas' Theory of Natural Law, I investigate Euro-Christian conceptions of naturalness and unnaturalness and how they were weaponized to cast racialized groups as perverse in the construction of the United States. I focus on the enforcement of Euro-heteropatriarchy to demonize Indigenous family and gender structures, as well as the characterization of Black bodies as abnormal by white academia to demonstrate some of the ways gender and sexuality have been colonized in the U.S. My research provides a general outline tracing a genealogy of deviance as established by Euro-Christian norms of sexuality and gender, which emerges from a …

A Literary Examination Of The Efficacy Of Zoological Conservation In The United States Versus Foreign Efforts, Madeleine M. Lecorre

University Honors Theses

Falling into the top four threats to biodiversity, human activity is impacting species around the globe like never before. Zoological conservation of threatened species aids in the support and reestablishment of these dwindling populations. The examination of conservation work done in the U.S compared to foreign efforts provides insight into strengths, reveals weaknesses, and will help us better serve threatened species around the world. The status of conservation in the U.S. as well as foreign efforts were assessed through literary review of published reports from accredited organizations. As zoologic conservation aims to conserve threatened species, it is also important to …

Views On Aging – Current Trends And Future Directions For Cross-Cultural Research, Anna E. Kornadt, Clara De Paula Couto, Klaus Rothermund

Online Readings in Psychology and Culture

The investigation of what enables societies and individuals to age well remains one of the greatest challenges of our time. Views on aging are a decisive factor in this process, and thus, improving their understanding through cross-cultural research is of utmost importance. In the current review, we address the role of socio-ecological variables and cultural values and beliefs when investigating country differences in what people think about older persons and getting old themselves. Several complexities are introduced in terms of a differentiated conceptualization of views on aging that takes life domains and normative prescriptions into account, and also in terms …

Multidisciplinary Simulation Improves Resident Confidence For Pregnant Patients Requiring Surgical Intervention., James Harrington, Gary Duncan, Karen Dangelo, Brad D Gable

Women’s Health Articles

INTRODUCTION: Hepatocellular adenomas are a rare but serious cause of bleeding, which is further complicated by pregnancy. Interprofessional cooperation is a key component of residency education, thus simulations designed to integrate multiple programs are mutually beneficial. This simulation details surgical and obstetric management of a pregnant patient in hemorrhagic shock from a bleeding hepatocellular adenoma. Objectives for the study were to evaluate learners' confidence to 1) prioritize the care of a pregnant patient with hemoperitoneum and hemorrhagic shock, 2) demonstrate interdisciplinary collaboration with other specialties, 3) apply massive transfusion protocol (MTP) in the appropriate clinical setting, and 4) analyze critical …

Longitudinal And Cross-Sectional Validation Of The Wercap Screen For Assessing Psychosis Risk And Conversion, Daniel Mamah, Victoria N Mutiso, David M Ndetei

2020-Current year OA Pubs

BACKGROUND: The Washington Early Recognition Center Affectivity and Psychosis (WERCAP) Screen was developed to assess risk for developing psychosis. Its validity has not been investigated in a large population-based study or with longitudinal analyses.

METHODS: 825 participants, aged 14-25, were recruited from Kenya. Symptoms were assessed using the WERCAP Screen, as experienced over the prior 3-months (3MO), 12-months (12MO) or lifetime (LIF). ROC curve analysis was used to determine the validity of the WERCAP Screen against the Structured Interview of Psychosis-Risk Syndromes. Longitudinal validity was assessed by comparing baseline p-WERCAP scores in psychotic disorder converters and non-converters, and using ROC …

Gender Parity In Authorship Of Published Randomized Clinical Trials In Stroke Neurology From 2000 To 2021., Noor F Shaik, Ali A Saherwala, Diana L Tzeng

Department of Neurology Faculty Papers

Gender parity is a crucial goal in clinical medicine so that women have equal access and representation. Although approximately half (46%) of US neurology residents and fellows are female, proportions of female assistant, associate, and full professors are 49%, 41%, and 23%, respectively. This has far-reaching effects, from clinical publications to invited speakerships.Although a study noted increasing trends in female authorship in high-impact neurology journals the current literature lacks evidence on a more informative benchmark—first and last authorship in randomized clinical trials (RCTs), which is typically considered for career advancement. This study assessed annual proportions and trends of female first …

Degenerative Cervical Myelopathy, Ratko Yurac, José Manuel Matamala, Juan José Zamorano, James S Harrop, Benjamin M Davies, Aria Nouri, Michael G Fehlings

Department of Neurology Faculty Papers

Degenerative cervical myelopathy (DCM) is the most common cause of spinal cord dysfunction in adults. Its prevalence is increasing as a result of population aging. The diagnosis of DCM is often delayed or overlooked, resulting in secondary neurologic morbidity. The natural course of DCM typically presents as a gradual neurological deterioration, with symptoms ranging from muscle weakness to complete paralysis, with variable degrees of sensory deficits and sphincter dysfunction. Magnetic resonance imaging (MRI) and electrophysiological studies allow the assessment of spinal cord function and its structural damage to determine treatment and clinical outcomes. All patients with signs and symptoms consistent …

High Resistance To Quinclorac In Multiple-Resistant Echinochloa Colona Associated With Elevated Stress Tolerance Gene Expression And Enriched Xenobiotic Detoxification Pathway, Gulab Rangani, Christopher E. Rouse, Christopher Saski, Rooksana E. Noorai, Vijay Shankar, Amy L. Lawton-Rauh, Isabel S. Werle, Nilda Roma-Burgos

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

Echinochloa colona and other species in this genus are a threat to global rice production and food security. Quinclorac, an auxin mimic, is a common herbicide for grass weed control in rice, and Echinochloa spp. have evolved resistance to it. The complete mode of quinclorac action and subsequent evolution of resistance is not fully understood. We analyzed the de novo transcriptome of multiple-herbicide-resistant (ECO-R) and herbicide-susceptible genotypes in response to quinclorac. Several biological processes were constitutively upregulated in ECO-R, including carbon metabolism, photosynthesis, and ureide metabolism, indicating improved metabolic efficiency. The transcriptional change in ECO-R following quinclorac treatment indicates an …

Measurable Microcystin In Ozark Streams Was Rare During Summer 2018 Baseflow Conditions, Bradley J. Austin, Brian E. Haggard

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

Accelerated eutrophication due to human activity has been linked to an increase in the occurrence of cyanobacteria in freshwater systems. The purpose of this study was to document the occurrence of microcystin, a common cyanotoxin, within northwest Arkansas streams. Twenty streams were sampled from May through October 2018, and water and periphyton samples were analyzed for microcystin and chlorophyll-a (CHL-a). Mean microcystin concentrations in water samples were low across sites, ranging from < 0.10 to 0.21 μg L⁻¹. Mean microcystin in the periphyton across sites ranged from 2.6 to 9.9 μg m⁻² and were within values observed in the literature. …

Health-Related Quality Of Life, Symptoms, And Tolerability Of Loncastuximab Tesirine In Patients With Relapsed Or Refractory Diffuse Large B-Cell Lymphoma, Alexander Spira, Xiaolei Zhou, Lei Chen, Ari Gnanasakthy, Luqiang Wang, David Ungar, Rafael Curiel, Laura Liao, John Radford, Brad Kahl

2020-Current year OA Pubs

BACKGROUND: Loncastuximab tesirine has shown antitumor activity with an acceptable toxicity profile in patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) who were relapsed or refractory after ≥2 prior therapies, including activity in patients with high-risk disease characteristics. This analysis examined health-related quality of life (HRQoL), symptoms, and tolerability in patients receiving loncastuximab tesirine for relapsed or refractory DLBCL.

PATIENTS AND METHODS: The single-arm, open-label phase II LOTIS-2 study (ADCT-402-201; NCT03589469) enrolled 145 patients aged ≥18 years. Patients received loncastuximab tesirine as a 30-minute intravenous infusion on day 1 of each 3-week treatment cycle. Patient-reported outcomes were measured …

Prolonged Response Of Recurrent Idh-Wild-Type Glioblastoma To Laser Interstitial Thermal Therapy With Pembrolizumab, Helen Hwang, Jiayi Huang, Karam Khaddour, Omar H Butt, George Ansstas, Jie Chen, Ruth Gn Katumba, Albert H Kim, Eric C Leuthardt, Jian L Campian

2020-Current year OA Pubs

Despite the improved understanding of the molecular and genetic heterogeneity of glioblastoma, there is still an unmet need for better therapeutics, as treatment approaches have remained unchanged in recent years. Research into the role of the immune microenvironment has generated enthusiasm for testing immunotherapy (specifically, immune checkpoint inhibitors). However, to date, trials of immunotherapy in glioblastoma have not demonstrated a survival advantage. Combination approaches aimed at optimally inducing response to immune checkpoint inhibitors with radiotherapy are currently being investigated. Herein, the authors describe their experience of the potential benefit and clinical outcomes of using combination pembrolizumab (an immune checkpoint inhibitor) …

Prevalence Of Surgical Procedures At Symptomatic Onset Of Prion Disease, Amanda L Porter, Christian C Prusinski, Evelyn Lazar, Clara Yuh, Robert C Bucelli, Brian S Appleby, Gregory S Day

2020-Current year OA Pubs

No abstract provided.

Numbers And Narratives: How Qualitative Methods Can Strengthen The Science Of Paediatric Antimicrobial Stewardship, Charlotte Z Woods-Hill, Anping Xie, John Lin, Heather A Wolfe, Alex S Plattner, Sara Malone, Kathleen Chiotos, Julia E Szymczak

2020-Current year OA Pubs

Antimicrobial and diagnostic stewardship initiatives have become increasingly important in paediatric settings. The value of qualitative approaches to conduct stewardship work in paediatric patients is being increasingly recognized. This article seeks to provide an introduction to basic elements of qualitative study designs and provide an overview of how these methods have successfully been applied to both antimicrobial and diagnostic stewardship work in paediatric patients. A multidisciplinary team of experts in paediatric infectious diseases, paediatric critical care and qualitative methods has written a perspective piece introducing readers to qualitative stewardship work in children, intended as an overview to highlight the importance …

Moving The Needle: Directed Intervention By The American Society For Surgery Of The Hand Is Effective In Encouraging Diversity In Expert Panel Composition, Lauren Elisabeth Wessel, Ambika E Paulson, Elizabeth A Graesser, Amy M Moore, Christopher J Dy

2020-Current year OA Pubs

PURPOSE: Recent efforts have been made by the American Society for Surgery of the Hand to encourage female inclusion in expert panels. We hypothesized that female representation on expert panels has increased over the past decade and that a directed intervention by the American Society for Surgery of the Hand would be associated with an increased percentage of submissions with female panelists.

METHODS: We performed a retrospective analysis of Instructional Course Lecture and Symposium submissions for the 2011 through 2021 American Society for Surgery of the Hand Annual Meetings. Authorship was reviewed, and the gender of the proposed authors was …

What Clinical Trials Are Needed For Treatment Of Leiomyosarcoma?, Bernd Kasper, Lorenzo D'Ambrosio, Elizabeth J Davis, Matthew Ingham, Javier Martin Broto, Jonathan C Trent, Winan J Van Houdt, Brian A Van Tine

2020-Current year OA Pubs

Leiomyosarcoma is one of the most common subtypes of soft tissue sarcomas accounting for approximately 20% of sarcomas. As leiomyosarcoma patients frequently develop metastatic disease, effective systemic therapies are needed to improve clinical outcomes. The overall activity of the currently available conventional systemic therapies and the prognosis of patients with advanced and/or metastatic disease are poor. As such, the treatment of this patient population remains challenging. As a result, there is a clear unmet medical need, and designing and performing meaningful clinical studies are of utmost importance to improve the prognosis of this patient group. Therefore, the aim of this …

Trabecular Meshwork Mitochondrial Function And Oxidative Stress: Clues To Racial Disparities Of Glaucoma, Hongli Wu, Ying-Bo Shui, Ying Liu, Xiaobin Liu, Carla J Siegfried

2020-Current year OA Pubs

PURPOSE: To identify racial differences of oxidative damage and stress and mitochondrial function in human trabecular meshwork (TM).

DESIGN: Experimental study.

PARTICIPANTS: One hundred seventy-three eyes of 173 patients undergoing intraocular surgery provided aqueous humor (AH) for analysis. Trabecular meshwork tissues from eye bank donors were used as healthy controls for primary cell culture.

METHODS: Enzyme-linked immunosorbent assay methods were used to measure 8-hydroxy-2-deoxyguanosine (8-OHdG), an oxidative damage marker, in AH comparing Black and White Americans. Human TM primary cultured cells from Black and White donors were used for adenosine triphosphate (ATP) measurement under high and low oxygen culture conditions. …

Comparison Of Standard And Penalized Logistic Regression In Risk Model Development, Yan Yan, Zhizhou Yang, Tara R Semenkovich, Benjamin D Kozower, Bryan F Meyers, Ruben G Nava, Daniel Kreisel, Varun Puri

2020-Current year OA Pubs

OBJECTIVE: Regression models are ubiquitous in thoracic surgical research. We aimed to compare the value of standard logistic regression with the more complex but increasingly used penalized regression models using a recently published risk model as an example.

METHODS: Using a standardized data set of clinical T1-3N0 esophageal cancer patients, we created models to predict the likelihood of unexpected pathologic nodal disease after surgical resection. Models were fitted using standard logistic regression or penalized regression (ridge, lasso, elastic net, and adaptive lasso). We compared the model performance (Brier score, calibration slope, C statistic, and overfitting) of standard regression with penalized …

Dmp1 Lineage Cells Contribute Significantly To Periosteal Lamellar Bone Formation Induced By Mechanical Loading But Are Depleted From The Bone Surface During Rapid Bone Formation, Taylor L Harris, Matthew J Silva

2020-Current year OA Pubs

Previous work has shown that osteoprogenitor cells (Prx1+) and pre-osteoblasts (Osx+) contribute to mechanical loading-induced bone formation. However, the role of mature Dmp1-expressing osteoblasts has not been reported. In this study we assessed the contribution of osteoblast lineage cells to bone formation at an early time point following mechanical loading (day 8 from onset of loading). We labeled Osx-expressing and Dmp1-expressing cells in inducible Osx and Dmp1 reporter mice (iOsx-Ai9, iDmp1-Ai9), respectively, 3 weeks before loading. Mice were then loaded daily for 5 days (days 1-5) and were dosed with 5-ethynyl-2'-deoxyuridine (EdU) in their drinking water until euthanasia on day …