Digital Commons Network^™

Brain Stereotactic Radiosurgery Using Mr-Guided Online Adaptive Planning For Daily Setup Variation: An End-To-End Test, Eun Young Han, He Wang, Tina Marie Briere, Debra Nana Yeboa, Themistoklis Boursianis, Georgios Kalaitzakis, Evangelos Pappas, Pamela Castillo, Jinzhong Yang

Faculty, Staff and Student Publications

Online magnetic resonance (MR)-guided radiotherapy is expected to benefit brain stereotactic radiosurgery (SRS) due to superior soft tissue contrast and capability of daily adaptive planning. The purpose of this study was to investigate daily adaptive plan quality with setup variations and to perform an end-to-end test for brain SRS with multiple metastases treated with a 1.5-Tesla MR-Linac (MRL). The RTsafe PseudoPatient Prime brain phantom was used with a delineation insert that includes two predefined structures mimicking gadolinium contrast-enhanced brain lesions. Daily adaptive plans were generated using six preset and six random setup variations. Two adaptive plans per daily MR image …

Of Vascular Defense, Hemostasis, Cancer, And Platelet Biology: An Evolutionary Perspective, David G Menter, Vahid Afshar-Kharghan, John Paul Shen, Stephanie L Martch, Anirban Maitra, Scott Kopetz, Kenneth V Honn, Anil K Sood

Faculty, Staff and Student Publications

We have established considerable expertise in studying the role of platelets in cancer biology. From this expertise, we were keen to recognize the numerous venous-, arterial-, microvascular-, and macrovascular thrombotic events and immunologic disorders are caused by severe, acute-respiratory-syndrome coronavirus 2 (SARS-CoV-2) infections. With this offering, we explore the evolutionary connections that place platelets at the center of hemostasis, immunity, and adaptive phylogeny. Coevolutionary changes have also occurred in vertebrate viruses and their vertebrate hosts that reflect their respective evolutionary interactions. As mammals adapted from aquatic to terrestrial life and the heavy blood loss associated with placentalization-based live birth, platelets …

The Degenerative Impact Of Hyperglycemia On The Structure And Mechanics Of Developing Murine Intervertebral Discs, Marianne Lintz, Remy E Walk, Simon Y Tang, Lawrence J Bonassar

2020-Current year OA Pubs

INTRODUCTION: Diabetes has long been implicated as a major risk factor for intervertebral disc (IVD) degeneration, interfering with molecular signaling and matrix biochemistry, which ultimately aggravates the progression of the disease. Glucose content has been previously shown to influence structural and compositional changes in engineered discs in vitro, impeding fiber formation and mechanical stability.

METHODS: In this study, we investigated the impact of diabetic hyperglycemia on young IVDs by assessing biochemical composition, collagen fiber architecture, and mechanical behavior of discs harvested from 3- to 4-month-old db/db mouse caudal spines.

RESULTS: We found that discs taken from diabetic mice with elevated …

Current State And Future Directions Of Genomic Medicine In Aortic Dissection: A Path To Prevention And Personalized Care, Alana C Cecchi, Madeline Drake, Chrisanne Campos, Jake Howitt, Jonathan Medina, Scott M Damrauer, Sherene Shalhub, Dianna M Milewicz, Aortic Dissection Collaborative

Faculty, Staff and Student Publications

Aortic dissection confers high mortality and morbidity rates despite advances in treatment, impacts quality of life, and contributes immense burden to the healthcare system globally. Efforts to prevent aortic dissection through screening and management of modifiable risk factors and early detection of aneurysms should incorporate genomic information, as it is integral to stratifying risk. However, effective integration of genomic-guided risk assessment into clinical practice will require addressing implementation barriers that currently permeate our healthcare systems. The Aortic Dissection Collaborative was established to define aortic dissection research priorities through patient engagement. Using a collaborative patient-centered feedback model, our Genomic Medicine Working …

Commentary On “Burnout And The Sexual Assault Nurse Examiner: Who Is Experiencing Burnout And Why?”, Jacqueline Callari Robinson, Jeneile Luebke, Sarah J. Hoffman, Kaylen M. Moore, Peninnah M. Kako, Lucy Mkandawire-Valhmu

College of Nursing Faculty Research and Publications

In the paper Burnout and the Sexual Assault Nurse Examiner: Who is Experiencing Burnout and Why? in this edition of the Journal of Emergency Nursing (JEN), Zelman et al examine the frequency of burnout and its accompanying features among sexual assault nurse examiners (SANEs) in North Carolina using the Maslach Burnout Inventory scale. The authors’ cross-sectional study provides the field of forensic nursing with essential knowledge and contextual understanding of burnout among SANEs working within forensic programs and those working in emergency departments of varying sizes, including some located in rural areas. The knowledge garnered from this study is also …

Using Repeated Reading And Previewing Vocabulary Interventions With Elementary-Aged Struggling Readers To Improve Fluency And Comprehension, Khaled S. Alotaibi

Communication Disorders & Special Education Theses & Dissertations

Students with Learning disabilities and at risk for reading difficulties often face challenges in reading fluency and comprehension that impact negatively on academic success. Repeated reading (RR) is an intervention designed to increase reading fluency and comprehension skills among students at risk and diagnosed with disabilities. The purpose of this review was to investigate the effectiveness of the repeated reading (RR) and vocabulary previewing (VP) interventions on the fluency and comprehension skills of elementary school students. The review yielded a modest number of research articles published between 2008 and 2019. The results of these studies suggested that RR can have …

The Epistemology Of Second Best, Gary S. Lawson

Faculty Scholarship

Second best theory “holds that where it is not possible to satisfy all the conditions necessary for a[] . . . system to reach an overall optimum, it is not generally desirable to satisfy as many of those conditions as possible.” Adrian Vermeule, Foreword: System Effects and the Constitution, 123 HARV. L. REV. 4, 17 (2009). In other words, if you are not moving all the way to the ideal state of affairs, it is unclear whether partial moves that seem to go in the direction of the ideal make the world “better” or “worse” – with “better” or “worse” …

Newly Identified Cardiomyopathy Often Presents With Advanced, Global Cardiac Remodeling When Associated With Atrial Fibrillation, Vinay Mehta, Alexander Albers, Maharaj Singh, Timothy E. Paterick

College of Nursing Faculty Research and Publications

Background: AF concurrent with cardiomyopathy is associated with increased morbidity and mortality. There is limited research comparing the extent of cardiac remodeling present in patients with new-onset cardiomyopathy (CM) associated with atrial fibrillation (AF) (AF-CM group) to that present in patients with new-onset CM without any concomitant or antecedent dysrhythmia (CM group). This study aimed to evaluate the extent of baseline cardiac remodeling present in patients with new-onset CM with and without AF. This review does not attempt to address the gap in knowledge of the mechanisms or the temporal relationship of AF-associated remodeling in patients with CM and AF. …

Surgical Outcomes Of Severe Spinal Deformities Exceeding 100° Or Treated By Vertebral Column Resection (Vcr). Does Implant Density Matter?: An Observational Study Of Deformity Groupings, Oheneba Boachie-Adjei, Henry Ofori Duah, Arthur Sackeyfio, Kwadwo P. Yankey, Lawrence G. Lenke, Paul Sponseller, Amer F. Samdani, Daniel J. Sucato, Brenda Sides, Peter Newton, Suken Shah, Harry Akoto, Munish Gupta, Fox Pediatric Spinal Deformity Study

College of Nursing Faculty Research and Publications

Study design

Prospective multicenter international observational study.

Objective

To investigate the effect of implant density on clinical outcomes in complex pediatric spine reconstruction.

Summary of background data

Implant density in spine deformity surgery has been a subject of much debate with some authors advocating higher density for better correction. Few studies have looked at the effect of implant density on severe curves > 100 deg or treated with vertebral column resection (VCR).

Methods

250/311 pts with 2-year f/u enrolled in the FOX pediatric database from 17 international sites were queried for the impact of implant density and surgical outcomes. Patients were …

Value Of Measurable Residual Disease Monitoring In Patients With Acute Promyelocytic Leukemia In The Era Of Frontline ‘Chemotherapy-Free’ Therapy, Jorge M Ramos Perez, Keyur P Patel, Sanam Loghavi, Guillermo Garcia-Manero, Gautam Borthakur, Elias Jabbour, William Wierda, Sherry Pierce, Mark Brandt, Steven Kornblau, Tapan Kadia, Naval Daver, Courtney D Dinardo, Nitin Jain, Musa Yilmaz, Nicholas Short, Srdan Verstovsek, Alessandra Ferrajoli, Michael Andreeff, Marina Konopleva, Daniel Rivera, David Mccue, Hagop M Kantarjian, Farhad Ravandi

Faculty, Staff and Student Publications

Acute promyelocytic leukemia (APL) is characterized by the chromosomal translocation t(15;17) and the resulting gene PML-RARA, used for measurable residual disease (MRD) monitoring. Despite highly effective therapy for APL, MRD monitoring practices are not fully established. We aimed to assess the value of MRD monitoring by RT-qPCR in patients with APL treated with ATRA and arsenic trioxide +/- GO. We reviewed 223 patients with APL treated with this regimen. RT-qPCR for PML-RARA was measured every 3 months, and at 12, 18, and 24 months after therapy. Seven patients relapsed. Time to relapse was 7.9-12.4 months in 6 patients, and …

Pandemic Visitor Policies: Parent Reactions And Policy Implications, Ashlee J. Vance, Kathryn J. Malin, Annella Benjamin, Clayton J. Shuman, Tiffany A. Moore, Deena K. Costa

College of Nursing Faculty Research and Publications

No abstract provided.

A Scoping Review Of The Experiences Of Adolescents And Young Adults In The Icu, Their Family Members, And Their Health Care Team, Natalie S. Mcandrew, Jeanne Erickson, Jill L. Guttormson, Alexandrea Bear, Sean Marks, Jayshil Patel, Eric Harding

College of Nursing Faculty Research and Publications

No abstract provided.

Association Of Geriatric Emergency Department Post-Discharge Referral Order And Follow-Up With Healthcare Utilization, Michelle Simpson, Clinton Sergi, Aaron Malsch, Suzanne Ryer, Christopher Rubach, Maharaj Singh

College of Nursing Faculty Research and Publications

Background

Compared with younger adults who receive care in the emergency department (ED), older patients who are discharged home have greater risk of adverse health outcomes. Connecting older adults with outpatient care following ED discharge are among the guidelines of the Geriatric Emergency Department (GED). The objective of this study was to examine the association between referral order placed during the ED visit for older adults and post-discharge follow-up to the outcomes of 72-h ED revisit, 30-day ED revisit, and 30-day all cause and unplanned hospital admission.

Methods

We conducted a retrospective cohort study. Ten accredited GEDs within one midwestern …

Outcomes Of Acute Versus Subacute Scapholunate Ligament Repair, Raymond E Chen, Ryan P Calfee, Jeffrey G Stepan, Daniel A Osei

2020-Current year OA Pubs

PURPOSE: This study investigated the long-term outcomes of direct scapholunate ligament (SLL) repairs with or without dorsal capsulodesis performed within 6 weeks (acute repair) of a SLL tear versus 6 to 12 weeks following injury (subacute repair).

METHODS: A review of medical records from April 1996 to April 2012 identified 24 patients who underwent SLL repair (12 acute, 12 subacute). Patients returned to the clinic for radiographic examinations of the injured wrist, standardized physical examinations, and validated questionnaires.

RESULTS: The mean follow-up times for the acute and subacute groups were 7.2 and 6.2 years, respectively. At the final examination, patients …

Glutathione S-Transferase: A Candidate Gene For Berry Color In Muscadine Grapes (Vitis RotundifoliA), Aruna Varanasi, Margaret Worthington, Lacy Nelson, Autumn Brown, Thomas Mason Chizk, Renee Threlfall, Luke Howard, Patrick Conner, Rosa Figueroa-Balderas, Melanie Massonnet, Dario Cantu, John R. Clark

Horticulture Faculty Publications and Presentations

Muscadine grapes (Vitis rotundifolia Michx.) are a specialty crop cultivated in the southern United States. Muscadines (2n = 40) belong to the Muscadinia subgenus of Vitis, while other cultivated grape species belong to the subgenus Euvitis (2n = 38). The muscadine berry color locus was mapped to a 0.8 Mbp region syntenic with chromosome 4 of Vitis vinifera. In this study, we identified glutathione S-transferase4 as a likely candidate gene for anthocyanin transport within the berry color locus. PCR and Kompetitive allele-specific PCR genotyping identified a single intragenic SNP (C/T) marker corresponding to a proline …

International Stroke Genetics Consortium Recommendations For Studies Of Genetics Of Stroke Outcome And Recovery, Arne G Lindgren, Jin-Moo Lee, Et Al

2020-Current year OA Pubs

Numerous biological mechanisms contribute to outcome after stroke, including brain injury, inflammation, and repair mechanisms. Clinical genetic studies have the potential to discover biological mechanisms affecting stroke recovery in humans and identify intervention targets. Large sample sizes are needed to detect commonly occurring genetic variations related to stroke brain injury and recovery. However, this usually requires combining data from multiple studies where consistent terminology, methodology, and data collection timelines are essential. Our group of expert stroke and rehabilitation clinicians and researchers with knowledge in genetics of stroke recovery here present recommendations for harmonizing phenotype data with focus on measures suitable …

Gender Gaps In Math Performance, Perceived Mathematical Ability And College Stem Education: The Role Of Parental Occupation, Lina Anaya, Frank P. Stafford, Gema Zamarro

Education Reform Faculty and Graduate Students Publications

Despite the promising future of employment opportunities in occupations related to Science, Technology, Engineering, and Mathematics (STEM), women remain underrepresented in some STEM occupational fields. We use data from the Panel Study of Income Dynamics to study the role of gender differences in achievement and self-perceived ability in math during childhood, along with parental occupation (science-related versus non-science-related jobs), in the subsequent decision of majoring in science in college. Our findings suggest a loss in STEM enrollment by otherwise qualified young women and highlight the potential importance of parental occupation in STEM in encouraging women's participation in certain STEM fields.

Comparison Of Performance Of Psychiatrists Vs Other Outpatient Physicians In The 2020 Us Medicare Merit-Based Incentive Payment System, Andrew C Qi, Karen E Joynt Maddox, Laura J Bierut, Kenton J Johnston

2020-Current year OA Pubs

Importance: Medicare's Merit-Based Incentive Payment System (MIPS) is a new, mandatory, outpatient value-based payment program that ties reimbursement to performance on cost and quality measures for many US clinicians. However, it is currently unknown how the program measures the performance of psychiatrists, who often treat a different patient case mix with different clinical considerations than do other outpatient clinicians.

Objective: To compare performance scores and value-based reimbursement for psychiatrists vs other outpatient physicians in the 2020 MIPS.

Design Setting and Participants: In this cross-sectional study, the Centers for Medicare & Medicaid Services Provider Data Catalog was used to identify outpatient …

Acculturation Implications On Obesity Among Ethnically Diverse Teens, Tien Vo, Lori A. Spruance

Faculty Publications

Obesity is a prevalent public health concern among children, especially those from minoritized backgrounds. In order to understand how acculturation and race/ethnicity influence obesogenic behavior in adolescents, a national convenience sample of 11- to 14-year-olds was recruited to participate in a survey about acculturation, physical activity, nutrition, and the school and home environment. Preliminary results showed significant differences in obesogenic behaviors when comparing White to non-White groups. Time spent watching TV, time spent playing video/computer games, and physical inactivity was higher for non-White Westernized adolescents compared to White adolescents. self-reported obesity, participation in school meals were both positively correlated with …

Tax Evasion And Fraud In The United States Sex Market, Youngbee Dale

Dignity: A Journal of Analysis of Exploitation and Violence

This study describes tax evasion or fraud in the United States sex market. Prior to this study, scholars have recognized the problem of tax evasion in the commercial sex market as an obstacle to national revenue collection. Tax violation and fraud investigations also are ways to combat the illegal commercial sex industry. However, no studies have focused on the problem in the United States sex market. Hence, this study aims to describe tax evasion or fraud methods used by the criminals operating in the United States sex market. This study relies on both quantitative and qualitative methods to examine the …

Prediction Of Bystander Intervention Behavior In A Sexual Assault Situation: The Role Of Religiosity, Empathy, And Gratitude, John D. Foubert, Mwarumba Mwavita, Kelva Hunger, Wei-Kang Kao, Pam Pittman-Adkins

Dignity: A Journal of Analysis of Exploitation and Violence

Bystander intervention in potential sexual assault situations is a common method of helping to address sexual violence on college campuses. Although numerous variables have been shown to mediate bystander intervention behavior, the pool of potential correlates is limited. The present study used regression analysis to determine the relationship between bystander behavior and three predictors: religiosity, gratitude, and victim empathy. Consistent with prior research, both religiosity and gratitude significantly predicted bystander behavior. Contrary to prior research, the relationship between victim empathy and bystander behavior was negative. Findings are discussed relating to potential bystander intervention programs, and future research, particularly on gratitude, …

Sexual Coercion, Unintended Pregnancy, And Poor Reproductive Health Among Adolescent Girls (Aged 13 - 19) In Mexico, Arun Kumar Acharya, Maria Luisa Martinez

Dignity: A Journal of Analysis of Exploitation and Violence

In Mexico, nearly 23,000 adolescents between the ages of 12-17 years suffer sexual coercion every year. This group also has a high birth rate of 77/1,000 adolescents, which indicates that one in every five pregnant women is an adolescent. This study describes the sexual coercion of victims and their views regarding the experience based on data collected from 37 Mexican girls between the age of 13 to 19, selected purposively using the snowball method in Monterrey city, Mexico. Results indicate that sexual coercion among adolescents is a serious problem, where 70% of adolescents experienced vaginal sexual coercion, nearly 22% experienced …

‘They Did Not Have To Burn My Sister Alive’: Causes And Distribution By State Of Dowry Murder In India, Peter Mayer

Dignity: A Journal of Analysis of Exploitation and Violence

Dowry, the money, goods, property, or gifts given by the bride’s family to the groom or his family at the time of marriage, is a common custom in South Asia. Although it is illegal to demand—or offer—a dowry in India, it is a nearly universal custom in many parts of the country. If, after marriage, a husband’s family feels that the wife’s dowry was insufficient, they may harass or inflict other forms of domestic violence on her to put pressure on her family to provide an additional dowry. At its most extreme, this violence may lead to the murder of …

The Broken Fourth Amendment Oath, Laurent Sacharoff

Hofstra Law Faculty Scholarship

The Fourth Amendment requires that warrants be supported by "Oath or affirmation." Under current doctrine, a police officer may swear the oath to obtain a warrant merely by repeating the account of an informant. This Article shows, however, that the Fourth Amendment, as originally understood, required that the real accuser with personal knowledge swear the oath.

That real-accuser requirement persisted for nearly two centuries. Almost all federal courts and most state courts from 1850 to 1960 held that the oath, by its very nature, required a witness with personal knowledge. Only in 1960 did the Supreme Court hold in Jones …

High-Resistance Connection Diagnosis In Five-Phase Pmsms Based On The Method Of Magnetic Field Pendulous Oscillation And Symmetrical Components, Hao Chen, Jiangbiao He, Xing Guan, Nabeel Demerdash, Ayman M. El-Refaie, Christopher H.T. Lee

Electrical and Computer Engineering Faculty Research and Publications

An online approach for diagnosing high-resistance connection (HRC) faults in five-phase permanent magnet synchronous motor drives is presented in this article. The development of this approach is based on a so-called “magnetic field pendulous oscillation (MFPO)” technique and symmetrical components method. Under HRC fault condition, a “swing-like” MFPO phenomenon is observed compared to the healthy condition. Furthermore, with the extracted current features in symmetrical components domain, different HRC fault types are successfully identified and distinguished. These fault types include single-phase faults, e.g., HRC fault in phase-A; two-phase nonadjacent faults, e.g., HRC fault in phase-A&C; and two-phase adjacent faults, e.g., HRC …

Documenting An Open Future In A Post-Policy World, Caitlin Harrington, Rachel E. Scott

Faculty and Staff Publications – Milner Library

This session continues the work of a 2019 survey that investigated library policies related to Open Access (OA). Specifically, this study sought to address the self-selection of participants by randomly selecting and directly contacting academic librarians at libraries within one of four different Carnegie classifications to request input on their library’s collection development policies and the existence of OA policies or informal practices related to library collections. The findings surface disparities in the documentation of OA collection practices among institution classifications and highlight concerns about both OA and policies in the collections strategies of academic libraries.

Double The Vocation, Double The Awe: An Examination Of Vocational Awe In Music Librarianship, Z. Sylvia Yang, Emily Vickers

Library Faculty Publications

Building upon Ettarh’s call to dismantle vocational awe in librarianship, this article outlines the shared components of Western libraries and Western music that lay the groundwork for vocational awe in each of these institutions and explores the ways in which vocational awe uniquely manifests for workers in the interdisciplinary field of music librarianship. The article explores the narrative of music’s goodness, disciplinary training, and manifestations of vocational awe as they appear in the institutional cultures of practice of music and librarianship: inability to develop work-life balance, job creep, low morale, and inequitable compensation. In naming this phenomenon as it is …

Stock Cut Flower Production In Utah, Maegen Lewis, Melanie Stock, Brent Black, Dan Drost

All Current Publications

Stock (Matthiola incana) is a cool-season annual in Utah with the highest quality stems being produced in spring and fall. Plants produce a single stem with either single or double florets that are known for their sweet and strong clove-like scent. Stock can be transplanted in the high tunnel and field in early spring and is tolerant of light frosts. Stems require a trellis to promote straight growth and can reach 36 inches tall. In North Logan, UT, stock grown in a high tunnel began blooming 5-10 weeks earlier, had 55% greater marketability, and stems averaged 4-8 inches …

Assessing The Contribution Of Rare Variants To Complex Trait Heritability From Whole-Genome Sequence Data, Pierrick Wainschtein, Deepti Jain, Zhili Zheng, Stella Aslibekyan, Diane Becker, Wenjian Bi, Jennifer Brody, Jenna C. Carlson, Adolfo Correa, John Blangero

School of Medicine Publications

Analyses of data from genome-wide association studies on unrelated individuals have shown that, for human traits and diseases, approximately one-third to two-thirds of heritability is captured by common SNPs. However, it is not known whether the remaining heritability is due to the imperfect tagging of causal variants by common SNPs, in particular whether the causal variants are rare, or whether it is overestimated due to bias in inference from pedigree data. Here we estimated heritability for height and body mass index (BMI) from whole-genome sequence data on 25,465 unrelated individuals of European ancestry. The estimated heritability was 0.68 (standard error …

“I Went Into This As One Person, And Then Came Out A Totally Different Person”: Native Lgbtq2s+ Young Adults’ Conceptions Of Trauma, Rachel M. Schmitz, Ruby Charak

Psychological Science Faculty Publications

Intersecting sources of stigma influence harmful mental health outcomes for lesbian, gay, bisexual, transgender, queer, and Two-Spirit (LGBTQ2S+) young adults (YA) of color as they must manage multiple oppressions. Experiencing both mental health challenges and victimization, LGBTQ2S+ YA of color struggle with distinctive psychological traumas. There is a critical need to determine how certain groups of LGBTQ2S+ YA of color’s marginalized social statuses shape trauma understandings. Native LGBTQ2S+ people in general endure diverse forms of oppression and trauma, such as histories of colonialism, contemporary racism, sexism, homophobia, and classism. Understanding the subjective interpretations of violence and trauma among Native LGBTQ2S+ …