Digital Commons Network^™

Search For Intermediate-Mass Black Hole Binaries In The Third Observing Run Of Advanced Ligo And Advanced Virgo, R. Abbott, T. D. Abbott, F. Acernese, K. Ackley, Teviet Creighton, Mario C. Diaz, Francisco Llamas, Soma Mukherjee, Volker Quetschke, Wenhui Wang

Physics & Astronomy Faculty Publications

Intermediate-mass black holes (IMBHs) span the approximate mass range 100−10⁵ M_⊙, between black holes (BHs) that formed by stellar collapse and the supermassive BHs at the centers of galaxies. Mergers of IMBH binaries are the most energetic gravitational-wave sources accessible by the terrestrial detector network. Searches of the first two observing runs of Advanced LIGO and Advanced Virgo did not yield any significant IMBH binary signals. In the third observing run (O3), the increased network sensitivity enabled the detection of GW190521, a signal consistent with a binary merger of mass ∼150 M_⊙ providing direct evidence of …

The Impact Of Light Rail Transit On The Urban Development In Dubai, Uae, Dhabia Nasser Alhazmi Alefari

Theses

The United Arab Emirates (UAE) has seen significant growth in urban development over the past two decades. To overcome the implication of this development, Dubai’s Roads and Transport Authority (RTA) has called for sustainable transport development at all levels, including the Light Rail Transit (LRT), which is a friendly mass transit system to satisfy the requirements of urban mobility, environmental sustainability, and green power efficiency. The shift towards sustainable mass transport systems has become the ideal choice to overcome the challenges accompanying the growth and development facing cities such as Dubai and to convert them into sustainable environmentally friendly places. …

A. T. Caedo And The University Of The Philippines: A Classical Sculptor's Contributions (1952-1972), Eugene Raymond P. Crudo

Journal Article

Anastacio T. Caedo is a forgotten classical sculptor whose contributions are ignored today. When Modernism gained a foothold in Philippine Art society, Caedo entered the University as faculty and served for twenty years. During those twenty years, some Caedo biographers missed noting his significant contributions to the University. Some of these works are icons of constituent universities for a time, while some are permanently exhibited, etched, and distributed. However, the problem remains that nobody remembers the artist behind them. Using periodicals, interviews, unpublished documents, and available scholarly research as a source of this article demonstrates the significant contributions of Anastacio …

Campbell Organ Festival: Celebrating 50 Years, Utah State University, Richard L. Elliot, Bradley Hunter Welch, Brian Mathias, Craig Jessop, Cory Evans

All Music Department Programs

As we approach the 50th Anniversary of the installation of the magnificent Holtkamp Organ at Utah State University, we reflect upon the generosity and vision of the original donors of the organ, Dr & Mrs. Melvin and Editha Kent. They, together with Glen L. Taggart, President of Utah State University from 1968-1979, Dr. Max Dalby, Head of the Department of Music, and a host of others contributed their time and resources to the creation of the Holtkamp Organ at USU.

Cervantes-Guevara V. District Court (Anderson), 138 Nev. Adv. Op 10 (Mar. 3, 2022), Jaden Braunagel

Nevada Supreme Court Summaries

No abstract provided.

Helix Electric Of Nevada, Llc V. Apco Construction, Inc. (Mar. 24, 2022), Anna Dreibelbis

Nevada Supreme Court Summaries

No abstract provided.

The Close Agn Reference Survey (Cars): Ifu Survey Data And The Bh Mass Dependence Of Long-Term Agn Variability, B. Husemann, M. Singha, J. Scharwächter, R. Mcelroy, J. Neumann, I. Smirnova-Pinchukova, T. Urrutia, S. A. Baum, V. N. Bennert, F. Combes, S. M. Croom, T. A. Davis, Y. Fournier, A. Galkin, M. Gaspari, H. Enke, M. Krumpe, C. P. O'Dea, M. Pérez-Torres, T. Rose, G. R. Tremblay, C. J. Walcher

Physics

Context. Active galactic nuclei (AGN) are thought to be intimately connected with their host galaxies through feeding and feedback processes. A strong coupling is predicted and supported by cosmological simulations of galaxy formation, but the details of the physical mechanisms are still observationally unconstrained.

Aims. Galaxies are complex systems of stars and a multiphase interstellar medium (ISM). A spatially resolved multiwavelength survey is required to map the interaction of AGN with their host galaxies on different spatial scales and different phases of the ISM. The goal of the Close AGN Reference Survey (CARS) is to obtain the necessary spatially resolved …

Parent-Of-Origin Effects Propagate Through Networks To Shape Metabolic Traits, Juan F. Macias-Velasco, Celine L.St Pierre, Jessica P. Wayhart, Li Yin, Larry Spears, Mario A. Miranda, Caryn Carson, Katsuhiko Funai, James M. Cheverud, Clay F. Semenkovich, Heather A. Lawson

Biology: Faculty Publications and Other Works

Parent-of-origin effects are unexpectedly common in complex traits, including metabolic and neurological traits. Parent-of-origin effects can be modified by the environment, but the architecture of these gene-by-environmental effects on phenotypes remains to be unraveled. Previously, quantitative trait loci (QTL) showing context-specific parent-of-origin effects on metabolic traits were mapped in the F16 generation of an advanced intercross between LG/J and SM/J inbred mice. However, these QTL were not enriched for known imprinted genes, suggesting another mechanism is needed to explain these parent-of-origin effects phenomena. We propose that non-imprinted genes can generate complex parent-of-origin effects on metabolic traits through interactions with imprinted …

Conserving The American Man: Gender, Eugenics And Education In The Civilian Conservation Corps, Charles Tocci, Ann Marie Ryan

Education: School of Education Faculty Publications and Other Works

The Civilian Conservation Corps (CCC) was a novel United States federal education programme that enrolled nearly three million men during the 1930s and early 1940s. This public work relief programme provides a case study of the ways that masculine, eugenicist ideas concerning public education evolved from the Progressive Era through the Great Depression. This educational philosophy was espoused by a small group of men – some educators, some not – who sought to remedy what they saw as the failures of public schooling, namely its overly feminine nature. Through an analysis of their public writings and the images that were …

Improved Characterization Of The Astrophysical Muon-Neutrino Flux With 9.5 Years Of Icecube Data, R. Abbasi, M. Ackermann, J. Adams, J. A. Aguilar, M. Ahlers, M. Ahrens, J. M. Alameddine, C. Alispach, A. A. Alves, N. M. Amin, K. Andeen, T. Anderson, G. Anton, C. Argüelles, Y. Ashida, S. Axani, X. Bai, A. Balagopal V., A. Barbano, S. W. Barwick, B. Bastian, V. Basu, S. Baur, R. Bay, J. J. Beatty

Physics: Faculty Publications and Other Works

We present a measurement of the high-energy astrophysical muon-neutrino flux with the IceCube Neutrino Observatory. The measurement uses a high-purity selection of 650k neutrino-induced muon tracks from the northern celestial hemisphere, corresponding to 9.5 yr of experimental data. With respect to previous publications, the measurement is improved by the increased size of the event sample and the extended model testing beyond simple power-law hypotheses. An updated treatment of systematic uncertainties and atmospheric background fluxes has been implemented based on recent models. The best-fit single power-law parameterization for the astrophysical energy spectrum results in a normalization of φ@100TeVνμ+ν¯μ=1.44-0.26+0.25×10-18GeV-1cm-2s-1sr-1 and a spectral …

Spartan Daily, March 1, 2022, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2022

Volume 158, Issue 14

Including Autistic Teens In Libraries, Aisling Smith

Articles

This article discusses the needs of autistic teenagers with low support needs and how best to cultivate and promote inclusivity in libraries to better serve this vulnerable sector of the community. Librarians should endeavour to understand the difficulties they encounter and how to minimize factors that might exacerbate these issues if autistic adolescents are to feel welcome and accepted.

“Something Would’Ve Been Better Than Nothing”: An Analysis Of Young Adults’ Stories Of Being Ghosted, Katherine Anne Holmes

Communication Studies

Utilizing the Narrative Paradigm (Fisher, 1984) and thematic analysis (Braun & Clarke, 2006), the present study seeks to explore and analyze stories of being ghosted from the perspective of young adults and to identify the themes that may animate these experiences. Recorded qualitative interviews with 21 young adults who had previously been ghosted resulted in 4 emergent themes: a) justifications b) confusion over responsibility c) avoiding future vulnerability and d) contribution of technology. Findings are consistent with previous research concerning ghosting and attachment theory, destiny beliefs, implicit theories of relationships, the role of technology, and more. Directions for future research …

The George-Anne Inkwell Edition, Georgia Southern University

The Inkwell

No abstract provided.

Getting Clear About Fuzzy Matching: A Guide To Matching Administrative Data Sets, Taylor Doren, Chia-Hua Yu, Benjamin Gronowski

Articles, Abstracts, and Reports

No abstract provided.

Pathways From Child Maltreatment To Proactive And Reactive Aggression: The Role Of Post-Traumatic Stress Symptom Clusters, Elizabeth M. Mcrae, Laura Stoppelbein, Sarah E. O'Kelley, Paula K. Fite, Shana B. Smith

Research, Publications & Creative Work

Objective: Childhood aggression is related to a myriad of negative concurrent and long-term outcomes. To mitigate the risks associated with childhood aggression, it is important to understand risk factors that might predispose one to aggressive behaviors. One risk factor commonly associated with aggression is the experience of child maltreatment. A common outcome associated with child maltreatment is the development of post-traumatic stress symptoms (PTSS). Several prevailing theoretical models of both post-traumatic stress and aggression indicate that these constructs have similar underlying cognitive, behavioral, and emotional mechanisms. Therefore, the present study examined the relations between and among child maltreatment, PTSS clusters, …

Molecular Epidemiology Of Mycobacterium Tuberculosis Complex Strains In Urban And Slum Settings Of Nairobi, Kenya, Glennah Kerubo, Perpetua Ndungu, Yassir Adam Shuaib, Evans Amukoye, Gunturu Revathi, Susanne Homolka, Samuel Kariuki, Matthias Merker, Stefan Niemann

Pathology, East Africa

Kenya is a country with a high tuberculosis (TB) burden. However, knowledge on the genetic diversity of Mycobacterium tuberculosis complex (MTBC) strains and their transmission dynamics is sparsely available. Hence, we used whole-genome sequencing (WGS) to depict the genetic diversity, molecular markers of drug resistance, and possible transmission clusters among MTBC strains in urban and slum settings of Nairobi. We analyzed 385 clinical MTBC isolates collected between 2010 and 2015 in combination with patients’ demographics. We showed that the MTBC population mainly comprises strains of four lineages (L1–L4). The two dominating lineages were L4 with 55.8% (n = 215) and …

Spiritual Warfare

Journal of Adventist Mission Studies

No abstract provided.

How To Engage Voluntary Spirit Possession Rituals In Mission: The Case Of The Dendi Adorcism Ritual, Michée Badé

Journal of Adventist Mission Studies

Missionaries face unique challenges when confronted with spirit possession rituals. Because not all spirit possessions are regarded as negative in some cultures, some spirit possessions are sought through adorcism rituals. Such spirit possessions are considered advantageous for the individual or the community. Contrasted with exorcism which is to expel or bind troublesome or uninvited entities, adorcism creates or strengthens beneficial ties between the possessed person and the spirits (Openshaw 2020:6).

This article seeks to show that the practice of adorcism rituals, as is the case among the Dendi people in the northern part of Benin, presents a unique challenge to …

Arkansas Soybean Performance Tests 2021, J. F. Carlin, R. B. Morgan, R. D. Bond

Arkansas Agricultural Experiment Station Research Series

Soybean variety and strain performance tests are conducted each year in Arkansas by the University of Arkansas System Division of Agriculture’s Arkansas Crop Variety Improvement Program. The tests provide information to companies developing varieties and/ or marketing seed within the state, and aid the Arkansas Cooperative Extension Service in formulating variety recommendations for soybean producers.

Zanubrutinib For Treatment-Naïve And Relapsed/Refractory Chronic Lymphocytic Leukaemia: Long-Term Follow-Up Of The Phase I/Ii Au-003 Study, Gavin Cull, Jan A Burger, Stephen Opat, David Gottlieb, Emma Verner, Judith Trotman, Paula Marlton, Javier Munoz, Patrick Johnston, David Simpson, Jennifer C Stern, Radha Prathikanti, Kenneth Wu, William Novotny, Jane Huang, Constantine S Tam

Faculty, Staff and Student Publications

The phase I/II AU-003 study in patients with treatment-naïve (TN) or relapsed/refractory (R/R) chronic lymphocytic leukaemia/small lymphocytic lymphoma demonstrated that zanubrutinib therapy results in clinically meaningful and durable responses with acceptable safety and tolerability. We report updated safety and efficacy data for 123 patients with a median follow-up of 47·2 months. Patients received zanubrutinib 160 mg twice daily (81 patients), 320 mg once daily (40), or 160 mg once daily (two). Discontinuations due to adverse events or disease progression were uncommon. The overall response rate (ORR) was 95·9% (TN, 100%; R/R, 95%) with 18·7% achieving complete response (CR). Ongoing response …

Targeting Mitochondrial Respiration And The Bcl2 Family In High-Grade Myc-Associated B-Cell Lymphoma, Giulio Donati, Micol Ravà, Marco Filipuzzi, Paola Nicoli, Laura Cassina, Alessandro Verrecchia, Mirko Doni, Simona Rodighiero, Federica Parodi, Alessandra Boletta, Christopher P Vellano, Joseph R Marszalek, Giulio F Draetta, Bruno Amati

Faculty, Staff and Student Publications

Multiple molecular features, such as activation of specific oncogenes (e.g., MYC, BCL2) or a variety of gene expression signatures, have been associated with disease course in diffuse large B-cell lymphoma (DLBCL), although their relationships and implications for targeted therapy remain to be fully unraveled. We report that MYC activity is closely correlated with-and most likely a driver of-gene signatures related to oxidative phosphorylation (OxPhos) in DLBCL, pointing to OxPhos enzymes, in particular mitochondrial electron transport chain (ETC) complexes, as possible therapeutic targets in high-grade MYC-associated lymphomas. In our experiments, indeed, MYC sensitized B cells to the ETC complex I inhibitor …

Monitoring Malignant T-Cell Clones By Direct Tcr Expression Assay In Patients With Leukemic Cutaneous T-Cell Lymphoma During Extracorporeal Photopheresis, Xiao Ni, Sourindra Maiti, Alissa Redko, Pedram Bijani, Madeleine Duvic

Faculty, Staff and Student Publications

Background/purpose: Accurate assessment of malignant T-cell clones in patients with leukemic cutaneous T-cell lymphoma (L-CTCL) is crucial for diagnosis, treatment, and monitoring disease. Although multiple approaches to quantitate malignant T-cell clones have been reported, a cost-effective assay with broad coverage is not available. We report a NanoString-nCounter-Technology-based direct TCR expression assay (DTEA) that was previously developed to quantify both TCR-Vα and TCR-Vβ usages after adoptive immunotherapy. This study was performed to test the effectiveness of DTEA in assessing malignant T-cell clones in L-CTCL patients.

Methods: Total RNAs extracted from peripheral blood mononuclear cells of patients before starting extracorporeal photopheresis (ECP) …

Dose Accumulation Of Daily Adaptive Plans To Decide Optimal Plan Adaptation Strategy For Head-And-Neck Patients Treated With Mr-Linac, Shin Yun Lim, Alan Tran, Anh Ngoc Kieu Tran, Angela Sobremonte, Clifton D Fuller, Lori Simmons, Jinzhong Yang

Faculty, Staff and Student Publications

Advances in magnetic resonance linear accelerators (MR-Linacs) allow for superior visualization of soft tissue to guide online adaptive replanning for precise radiotherapy delivery. Elekta Unity MR-Linacs (Elekta AB, Stockholm, Sweden) provides 2 plan adaptation approaches, adapt-to-position (ATP), plan reoptimization based on the reference CT with the iso-shift measured from daily MR scans, and adapt-to-shape (ATS), full plan reoptimization based on the re-contoured daily MR scans. Our study aims to close the gap in knowledge regarding the use of the ATP technique in the treatment of head and neck (HN) cancers through the analysis of accumulated dose of daily ATP plans …

Interleukin-6 Blockade Abrogates Immunotherapy Toxicity And Promotes Tumor Immunity, Ahmed Omar Kaseb, Elshad Hasanov, Hop Sanderson Tran Cao, Lianchun Xiao, Jean-Nicolas Vauthey, Sunyoung S Lee, Betul Gok Yavuz, Yehia I Mohamed, Aliya Qayyum, Sonali Jindal, Fei Duan, Sreyashi Basu, Shalini S Yadav, Courtney Nicholas, Jing Jing Sun, Kanwal Pratap Singh Raghav, Asif Rashid, Kristen Carter, Yun Shin Chun, Ching-Wei David Tzeng, Divya Sakamuri, Li Xu, Ryan Sun, Vittorio Cristini, Laura Beretta, James C Yao, Robert A Wolff, James Patrick Allison, Padmanee Sharma

Faculty, Staff and Student Publications

BACKGROUND: Hepatocellular carcinoma has high recurrence rates after surgery; however, there are no approved standard-of-care neoadjuvant or adjuvant therapies. Immunotherapy has been shown to improve survival in advanced hepatocellular carcinoma; we therefore aimed to evaluate the safety and tolerability of perioperative immunotherapy in resectable hepatocellular carcinoma.

METHODS: In this single-centre, randomised, open-label, phase 2 trial, patients with resectable hepatocellular carcinoma were randomly assigned (1:1) to receive 240 mg of nivolumab intravenously every 2 weeks (for up to three doses before surgery at 6 weeks) followed in the adjuvant phase by 480 mg of nivolumab intravenously every 4 weeks for 2 …

Metabolic Stress Induces Gd2+ Cancer Stem Cell-Like Phenotype In Triple-Negative Breast Cancer, Appalaraju Jaggupilli, Stanley Ly, Khoa Nguyen, Vivek Anand, Bin Yuan, Fouad El-Dana, Yuanqing Yan, Zoe Arvanitis, Danthasinghe Waduge Badrajee Piyarathna, Nagireddy Putluri, Helen Piwnica-Worms, Henry Charles Manning, Michael Andreeff, V Lokesh Battula

Faculty, Staff and Student Publications

Background: Metabolic stress resulting from nutrient deficiency is one of the hallmarks of a growing tumour. Here, we tested the hypothesis that metabolic stress induces breast cancer stem-like cell (BCSC) phenotype in triple-negative breast cancer (TNBC).

Methods: Flow cytometry for GD2 expression, mass spectrometry and Ingenuity Pathway Analysis for metabolomics, bioinformatics, in vitro tumorigenesis and in vivo models were used.

Results: Serum/glucose deprivation not only increased stress markers but also enhanced GD2+ BCSC phenotype and function in TNBC cells. Global metabolomics profiling identified upregulation of glutathione biosynthesis in GD2high cells, suggesting a role of glutamine in the BCSC phenotype. Cueing …

Stem Cell Architecture Drives Myelodysplastic Syndrome Progression And Predicts Response To Venetoclax-Based Therapy, Irene Ganan-Gomez, Hui Yang, Feiyang Ma, Guillermo Montalban-Bravo, Natthakan Thongon, Valentina Marchica, Guillaume Richard-Carpentier, Kelly Chien, Ganiraju Manyam, Feng Wang, Ana Alfonso, Shuaitong Chen, Caleb Class, Rashmi Kanagal-Shamanna, Justin P Ingram, Yamini Ogoti, Ashley Rose, Sanam Loghavi, Pamela Lockyer, Benedetta Cambo, Muharrem Muftuoglu, Sarah Schneider, Vera Adema, Michael Mclellan, John Garza, Matteo Marchesini, Nicola Giuliani, Matteo Pellegrini, Jing Wang, Jason Walker, Ziyi Li, Koichi Takahashi, Joel D Leverson, Carlos Bueso-Ramos, Michael Andreeff, Karen Clise-Dwyer, Guillermo Garcia-Manero, Simona Colla

Faculty, Staff and Student Publications

Myelodysplastic syndromes (MDS) are heterogeneous neoplastic disorders of hematopoietic stem cells (HSCs). The current standard of care for patients with MDS is hypomethylating agent (HMA)-based therapy; however, almost 50% of MDS patients fail HMA therapy and progress to acute myeloid leukemia, facing a dismal prognosis due to lack of approved second-line treatment options. As cancer stem cells are the seeds of disease progression, we investigated the biological properties of the MDS HSCs that drive disease evolution, seeking to uncover vulnerabilities that could be therapeutically exploited. Through integrative molecular profiling of HSCs and progenitor cells in large patient cohorts, we found …

Seventh Grade Book Club Unit, Emily Donnell

Honors Program: Senior Projects (Public)

The purpose of this book club unit is to teach students the valuable lessons they need to learn about adversity and emotions while still preparing them for the assessments that are required by school districts. This unit is centered around “Drums Girls and Dangerous Pie” and “Wonder”. These books are part of the required curriculum for on-level 7th graders within Lincoln Public Schools (LPS) in Lincoln, NE. Open discussions and collaboration are the two main ways that students will come to understandings within this unit.

Furthering Women In Policing: How A Police Department's Duty Firearm Selection Process May Mitigate The Gender Disparity In Marksmanship, Jenna Prochnau

Honors Program: Senior Projects (Public)

Previous research has revealed that there are several benefits to increasing the representation of women in law enforcement, including less use of force, increased community trust, and better outcomes for domestic violence and sexual assault victims. While many police departments now recognize these benefits and are aiming to recruit more women, a problem persists because women are less likely to graduate from police academies than their male counterparts. A significant difference has been observed in the area of marksmanship, particularly, with more female recruits failing to meet firearm scoring standards. Currently, very little is known about how police departments select …

Chronic Estrus Disrupts Uterine Gland Development And Homeostasis, C Allison Stewart, M David Stewart, Ying Wang, Rachel D Mullen, Bonnie K Kircher, Rui Liang, Yu Liu, Richard R Behringer

Faculty, Staff and Student Publications

Female mice homozygous for an engineered Gnrhr E90K mutation have reduced gonadotropin-releasing hormone signaling, leading to infertility. Their ovaries have numerous antral follicles but no corpora lutea, indicating a block to ovulation. These mutants have high levels of circulating estradiol and low progesterone, indicating a state of persistent estrus. This mouse model provided a unique opportunity to examine the lack of cyclic levels of ovarian hormones on uterine gland biology. Although uterine gland development appeared similar to controls during prepubertal development, it was compromised during adolescence in the mutants. By age 20 weeks, uterine gland development was comparable to controls, …