Digital Commons Network^™

The Prospector, March 3, 2026, Utep Student Publications

The Prospector

No abstract provided.

Post-Traumatic Stress Disorder And Risk Of All-Cause And Cause-Specific Mortality: A Nationwide Population And Sibling-Controlled Cohort Study In Taiwan, Chih-Wei Hsu, Yang-Chieh Brian Chen, Liang-Jen Wang, Mu-Hong Chen, Yao-Hsu Yang, Chih-Sung Liang, Edward Chia-Cheng Lai

Children’s Nutrition Research Center Staff Publications

Aims: Post-traumatic stress disorder (PTSD) may shorten life expectancy, but evidence for Asian populations and cause-specific mortality remains limited. The aim of this study is to investigate the association between PTSD and mortality risk in an Asian population.

Methods: We used Taiwan's National Health Insurance Research Database (2000-2022) to assemble a cohort of 28,777 individuals with incident PTSD and 115,108 age- and sex-matched unexposed individuals, plus a sibling cohort of 13,305 affected patients and 22,030 unaffected siblings. Cox models estimated adjusted hazard ratios (AHRs) for all-cause, unnatural-cause (suicide and accidents) and natural-cause mortality, with progressive adjustment for sociodemographic factors, comorbidity …

"Wellness 2 U” Program To Promote Nurse Leaders' Loving- Kindness Toward Self And Others, Linda Y. Kim, Akal Khalsa, Jennifer Astasio

Creating Healthy Work Environments (CHWE)

Problem/Background: A 2021 study by the American Organization for Nursing Leadership reported that sustainment of staff emotional health and well-being were top priorities for 75% of the nurse leader respondents.¹ Compassionate caring of others begins with loving-kindness toward self.² Nurse leaders must practice self-care and loving-kindness for themselves and role model it as a means of empowering and promoting wellness for their staff. Holistic and integrative strategies aimed at promoting nurse leader and staff well-being consequently promote a healing environment for authentic caring presence for patients.

Purpose/SMART Aims: This project aimed to promote nurse leader wellness …

Nurse Resident Job Satisfaction With A Formal Mentorship Program, Jessica Hoehne

Creating Healthy Work Environments (CHWE)

Purpose: Job satisfaction is a predictor of nursing turnover and intent to stay. New nurses are especially vulnerable to turnover during their first year creating a significant barrier to building the nursing workforce. Research shows reasons contributing to the high attrition rates of new nurses include a lack of confidence, an inability to cope with work-related stress and a decreased sense of belonging. Several studies have shown that mentorship promotes personal and professional development, increases learning, and builds confidence. The goal of implementing a mentorship program is to create a culture of support for nurse residents resulting in increased job …

Baccalaureate Nursing Students Identify Positive And Negative Belongingness Behaviors In Clinical Practice: Lessons For Clinicians, Missy Ofe Fleck, Cathrin L. Carithers, Lynnette Leeseberg Stamler, Leeza A. Struwe

Creating Healthy Work Environments (CHWE)

Creating inclusive clinical learning environments in which students thrive is a priority in nursing education and practice to foster belongingness (Metzger & Taggert, 2020), address person-centered care needs (Marjadi et al., 2023), and prepare a diverse nursing workforce (Charania & Patel, 2022). Relationships nurtured among health care team members and nursing students provide the fundamental social context for acceptance and efficacious learning (Levett-Jones et al., 2007). Levett-Jones and Lathlean (2008) identified belongingness as a “deeply personal and contextually mediated experience that evolves in response to the degree to which an individual feels (a) secure, accepted, included, valued, and respected by …

Berlin, Sherry, Jessica Amselem

Bronx Jewish History Project

Summarizer: Jessica Amselem

Sherry Berlin, grew up in multiple neighborhoods in the Bronx, beginning on Longfellow Avenue in the South Bronx and later moving at age five to Kingsbridge in the Northwest Bronx, near Riverdale. Her maternal grandparents immigrated from Poland/Russia and settled in the Bronx, where they owned grocery stores and remained closely involved in her upbringing. Berlin’s early childhood was rooted in a predominantly Jewish community, while her later years in Kingsbridge exposed her to a more ethnically mixed environment, including Irish and Italian neighbors.

Berlin’s movement across different parts of the Bronx shaped her experiences of community, …

The Link March 3, 2026, Access To Justice Institute

The Link Newsletter

No abstract provided.

Single Ventricle Physiology May Not Preclude Cardiac Repair In The Setting Of Congenital Diaphragmatic Hernia, Kylie I Holden, Michael C Scott, Ashley H Ebanks, Amir M Khan, D Michael Mcmullan, Anthony Johnson, Charles S Cox, Matthew T Harting, Damien J Lapar

The Brown Foundation: Institute of Molecular Medicine

Objective: Management for congenital heart disease (CHD) with congenital diaphragmatic hernia (CDH), particularly in single ventricle physiology, is challenging, with limited studies showing poor outcomes. This investigation evaluated outcomes for these complex patients.

Methods: This retrospective cohort study (2007-2022) from the CDH Study Group analyzed mortality in patients with CDH and single ventricle physiology, using standard statistical methods and Cox regression for estimation.

Results: A total of 9,261 CDH patients were identified, including 1,886 with CDH + CHD and 131 with single ventricle physiology. The median gestational age was 38 weeks and birthweight was 2.8 kg. Of 131 patients, 34 …

Mostly Haunted: A Socio-Spatial Analysis Of Ghost Tourism In England And Wales, Tom Clark, Joseph O. Baker, Christoper D. Bader

Sociology Faculty Articles and Research

There is now a well-established literature on ghost tourism. However, much of this work examines aspects associated with the demand side of the industry, or the motivations and experiences of consumers. There are currently no studies that have sought to explore the supply of ghost tourism and the spatial, social, and economic relationships that exist between these places. Using Lower Tier Local Authorities (LTLAs) in England and Wales as the units of analysis, this study draws on a bespoke range of local government and Census data to examine the prevalence of ghost tourism and explore how these sites are differentiated …

Robots, Ledgers, And Revpar: A Blockchain-Enabled Ai–Robotics Conceptual Model For Sustainable Hotel Revenue And Asset Management, Leonard A. Jackson

Faculty Articles

Introduction: Robotics and artificial intelligence (AI) are rapidly reshaping hospitality by automating frontline and back-of-house processes, augmenting service encounters, and expanding the analytical scope of revenue management. Yet, existing research remains fragmented: service-robot studies largely emphasize adoption and human–robot interaction, while revenue-management research prioritizes pricing and distribution, sustainability research focuses on environmental practices, and hotel real-estate scholarship foregrounds governance and asset value. Meanwhile, blockchain technologies—through distributed ledgers, smart contracts, digital identity, and tokenization—offer a complementary trust and value-transfer layer that can address coordination and verification problems across hotel ecosystems (e.g., data sharing, sustainability claims, and owner–operator contracting).

Methods: Drawing on …

Influence Of Body Composition On The Efficacy Of Nivolumab Plus Ipilimumab For Metastatic Clear Cell Renal Cell Carcinoma, Kabir Grewal, Maria Julia Moura Nascimento Santos, Pankaj Kumar Chauhan, Kai Yu, Nizar M Tannir, Sagar S Mukhida, Neha Venkatesh, Amishi Y Shah, Amado J Zurita, Andrew C Johns, Matthew T Campbell, Sangeeta Goswami, Jianjun Gao, Eric Jonasch, Jennifer L Mcquade, Omar Alhalabi, Pavlos Msaouel, Andrew W Hahn

Faculty, Staff and Student Publications

Background: Immune checkpoint inhibitor therapy (ICI) with nivolumab+ipilimumab is a first-line (1L) standard for metastatic clear cell renal cell carcinoma (ccRCC), yet outcomes remain heterogeneous. Increasing evidence suggests that host factors influence the tumor microenvironment and response to ICI. Although higher body mass index (BMI) has been associated with improved outcomes in several malignancies, BMI is an imprecise surrogate for underlying adipose and muscle compartments. We evaluated the association between body composition and outcomes with 1L nivolumab+ipilimumab in metastatic ccRCC.

Methods: We retrospectively analyzed patients with mccRCC treated with 1L nivolumab+ipilimumab at MD Anderson Cancer Center between June 2015 and …

Tongue Reduction For Pediatric Obstructive Sleep Apnea: A Systematic Review., Adrian Williamson, Rohit Nallani, Jason R. Brown

Manuscripts, Articles, Book Chapters and Other Papers

OBJECTIVE: Obstructive sleep apnea (OSA) is a prevalent pediatric disorder that, if untreated, can result in substantial developmental and health consequences. Tongue reduction procedures, such as midline posterior glossectomy (MPG), are increasingly used to address tongue base obstruction. This systematic review evaluates the effectiveness and safety of tongue reduction procedures for pediatric OSA.

DATA SOURCES: Embase, PubMed, and Web of Science databases were queried for studies from inception to September 20, 2023.

REVIEW METHODS: Studies reporting on outcomes of pediatric patients (≤21 years) undergoing tongue reduction surgery for OSA were included.

RESULTS: From 477 abstracts, 9 studies met the inclusion …

Pregnancy, Cancer, And Radiation-A Modern Refresher, Kelly Kisling, Sandra M Meyers, Rebecca Milman, Susan Richardson, Christina Chapman, Justine Dupere, Grace Eliason, Suzanne Evans, Titania Juang, Young Lee, Jeffrey Masten, Julia Maues, Rachel Newman, Mike Silosky, Catherine Song, Catheryn Yashar, Sara Thrower

Faculty, Staff and Student Publications

Cancer occurs in ∼1 per 1000 pregnancies; thousands of patients may require radiation procedures for diagnosis and treatment each year in the United States alone. This rare but high-risk scenario, coupled with fear of radiation, has created ambiguity in the ideal management of pregnant patients. Without a comprehensive guide for the use of radiation in imaging and treatment for pregnant cancer patients, it is difficult for providers to offer optimal patient-centered care without introducing disparities. The goal of this paper is to provide guidance on the use of radiation for screening, diagnosis, staging, and treatment of cancer, while highlighting gaps …

Proteomic Profiling Of Pulmonary Function And Cardiovascular Disease Risk In The Atherosclerosis Risk In Communities Study, Yura Lee, Astrid M Manuel, Ngoc Quynh H Nguyen, Christine Ladd-Acosta, Alanna C Morrison, Kari E North, Eric Boerwinkle, Amil M Shah, Zhongming Zhao, Stephanie J London, Bing Yu

Faculty, Staff and Student Publications

Background: Pulmonary function is linked to cardiovascular disease risk; however, the underlying mechanisms remain unclear. We aimed to identify protein biomarkers associated with pulmonary function and examine their impact on incident chronic obstructive pulmonary disease, coronary heart disease, heart failure, and all-cause mortality.

Methods: Data from White and Black Americans in the Atherosclerosis Risk in Communities study (visit 2: N=11 354, mean age=57 years; visit 5: N=3517, mean age=75 years), a prospective cohort, were analyzed. Linear regression assessed associations between protein levels and pulmonary function measures, including forced expiratory volume in 1 second and forced vital capacity. The impact of …

Early Childhood Echo (Ec Echo) Start-Up & Operations Manual, Lisa Long, I. Michelle Gaither, Ruby Brenner, Bradley Long, Emily Mcclelland, Malcolm Huell, Lauren Elliott, Katerina Sergi

Publications

The Early Childhood ECHO (EC ECHO) Start-up & Operations Manual is a practical guide to launching case-based telementoring and professional development using the Project ECHO® model. Prepared for early childhood programs and agencies. Adapted from Mississippi’s EC ECHO implementation (2023–2025) and aligned with Project ECHO® guidance.

Striving To Become A Dean Of Faculty Affairs And Development, Beatriz Tapia, Guadalupe Federico-Martinez

School of Medicine Publications

Academic medicine allows you to grow in your field of expertise and interest. Yet, the guidance you receive will provide you with the path toward successful professorial promotion. As a dean of faculty affairs and development, there is no greater pleasure than serving as a guide for faculty across their life cycle from recruitment to retirement and everything in between. In this chapter, you will find information regarding the dean of faculty affairs and development role. Depending on the maturity of your institution, you will need to define who is intended for you to serve and where the greatest needs …

Review Of Modern Methods For Identification, Forecasting, And Intelligent Control Of Wastewater Biological Treatment Processes, Mirkhalil Agzamovich Ismailov, Boburbek Zokirjon O'G'Li Mannobjonov

Chemical Technology, Control and Management

This article presents a comprehensive review of contemporary approaches to the automation and intelligent control of wastewater biological treatment processes. Particular emphasis is placed on the digitalisation of wastewater treatment plants, ranging from the implementation of automated process control systems (APCS/SCADA-based solutions) to the application of predictive algorithms and the development of digital twins of bioreactors.

Special attention is devoted to mathematical models that underpin the control of bioprocesses. The evolution of the most widely used activated sludge models—ASM1, ASM2d, and ASM3—is examined, as these models describe key processes such as microbial community growth, nitrification, denitrification, and phosphorus removal. It …

Place And Time: Interrogating The Spatial And Temporal Patterns Of Social Vulnerability In Tennessee, Max Bangham Dixon

Electronic Theses and Dissertations Archive

Social vulnerability is essential for research and as a framework in disaster management. Despite a common understanding that social vulnerability is spatially and temporally variable, the ways in which it is variable are not well understood. This research examines the dynamic nature of social vulnerability through two indices (SoVI and SVI) at a census tract-level using Fuzzy-C Means clustering and spatial analyses. Drivers of vulnerability are examined to understand what influences place-based vulnerability and discover how those drivers vary across space. Findings suggest that Fuzzy-C Means clustering is effective in creating interpretable groups of vulnerability indicators that are consistent with …

Arbitrability Of Government Contracts Disputes Between State Sovereignty And Investors’ Guarantees: A Comparative Study, Arem Sayed Aboelazm, Fady Tawakol, Mohammad Rababa

All Works

This paper examines the balance between state sovereignty and the subordination of states to non-national jurisdictions. It explores jurisprudential and legal perspectives on arbitration in state contracts and highlights its implications for the legal framework governing such contracts (Alanzi, 2021a; Abbas, 2020). The analysis focuses on Egypt and the United Arab Emirates (UAE), assessing the legitimacy of arbitration in state contracts within both jurisdictions. A descriptive-analytical method is applied to investigate the debates among public law scholars regarding the admissibility of arbitration in disputes involving state contracts, as well as the arguments underpinning their positions. In parallel, a comparative analytical …

Review On Data Privacy And Security For Iot-Based Multifunctional Layers Of Cyber-Physical Systems In Smart Grids, Mohammad Kamrul Hasan, Md Mehedi Hasan, Nabeel Al-Qirim, Siti Norul Huda Sheikh Abdullah, Shayla Islam, Md Abdur Razzaque

All Works

Smart grid cyber-physical systems (SG-CPS) are intelligent platforms that incorporate IoT-enabled multifunctional layers including the physical, perception, communication, cyber, and application layers. It includes supervisory control and data acquisition, wide-area measurement systems, and advanced metering infrastructure for remote data aggregation, monitoring, and control operations. From an environmental perspective, these green technologies support two-way operations, which generate and transmit data over wired and wireless communication systems. However, this critical infrastructure faces data privacy and cybersecurity challenges. Hence, extensive research is required to address data privacy and security gaps to strengthen national grid cybersecurity and reduce economic losses. Therefore, this review highlights …

The George-Anne Daily, Georgia Southern University

George-Anne Media Group: Newsletters & Magazines

No abstract provided.

The Price Of Democracy: The Revolutionary Power Of Taxation In American History, Vanessa Williamson

Brookings Scholar Lecture Series

As part of the Brookings Scholar Lecture Series, Brookings Mountain West presented a lecture titled, "The Price of Democracy: The Revolutionary Power of Taxation in American History" by Brookings senior fellow in governance studies, Vanessa Williamson.

From tariffs to “no tax on tips”, taxation has often been a hot topic in American elections. What is not commonly recognized, however, is that—from the framing of the Constitution to the decades-long backlash to the civil rights movement—taxes have been at the heart of battles over the breadth of our democracy. Brookings senior fellow Vanessa Williamson discusses her new book, The Price of …

Prevalence And Characteristics Of Workplace Violence Towards Healthcare Workers In Primary Healthcare Settings In Muscat, Oman, Manar Al Sanaa Ali Al Zeedi, Bishara Hamed Al Maamari, Khadija Saleh Alghammari, Aisha Rashid Al Mufarrji, Nahid Saif Al Hasni, Rahma Yaqoob Al Shuhaimi

Sultan Qaboos University Medical Journal

Objectives: Workplace violence (WPV) is a growing occupational health concern, with healthcare workers (HCWs) particularly at risk. While high rates of WPV towards HCWs have been reported in emergency and psychiatry settings in Oman, little is known about its prevalence in primary care. This study aimed to assess the prevalence and characteristics of WPV towards HCWs in primary care settings in Muscat, Oman. Methods: This cross-sectional study was conducted between November and December 2024 in Muscat's primary health centres using the validated Workplace Violence in the Health Sector Country Questionnaire. Descriptive statistics and inferential analyses (Chi-square and logistic regression) were …

Differences In Graft Rupture And Subsequent Meniscal Tears Following Adolescent Acl Reconstruction Using Quadriceps Tendon Versus Hamstrings Autograft: A Retrospective Study With Minimum 2-Year Follow-Up., Morgan E. Swanson, Christopher Defrancesco, Kevin M. Landrum, David Kell, Richa Gandhi, Sulagna Sarkar, Theodore J. Ganley, Kathleen J. Maguire

Department of Medicine Faculty Papers

BACKGROUND: Anterior cruciate ligament (ACL) reconstruction (ACLR) using quadriceps tendon (QT) autograft is associated with lower rates of graft rupture and favorable functional outcomes compared with hamstring (HS) autograft in adolescents. The ACL-deficient knee is at increased risk of injury to secondary stabilizers of the knee, including the menisci, although studies have not reported differences in rates of subsequent meniscal tear between HS and QT groups.

PURPOSE: The goal of this study was to compare rates of graft rupture and subsequent meniscal tear after adolescent ACLR using HS or QT autograft.

STUDY DESIGN: Cohort study; Level of evidence, 3.

METHODS: …

Clinical Validation Of Perfusion Imaging With Pulmonary Function Test Data Using Voronoi-Based Discretization, Jorge Cisneros, Caleb J. Herrera, Yi-Kuan Liu, Lisa V. Du, Yevgeniy Vinogradskiy, Richard Castillo, Girish Nair, Edward Castillo

Department of Medicine Faculty Papers

Objective.Accurate lung function assessment is essential for diagnosing and managing diseases like chronic obstructive pulmonary disorder, pulmonary emboli, and lung cancer. Single-photon emission computed tomography (SPECT) provides valuable 3D functional imaging of ventilation and perfusion, but is limited by low spatial resolution, availability, additional radiation, and cost. Alternative methods, including CT-based perfusion (CT-P) and deep learning models, require large datasets to validate results that are often scarce. Pulmonary function tests (PFTs) offer rapid and noninvasive global lung function measures and are clinically widely used. While ventilation correlates well with PFTs, perfusion imaging presents challenges due to complex blood flow and …

Association Between Functional Status And Cardiac Function In Chronic Heart Failure: Insights From The C-Mic Ii Trial., Marat Fudim, Tamara Kovacevic-Preradovic, Marija Zdravkovic, Sasko Jovev, Nermir Granov, Tanja Popov, Igor Rudez, Petar Vukovic, Velibor Ristic, Annette Holtdirk, Muhammad Shahzeb Khan, Faouzi Kallel, Miodrag Peric, Javed Butler, Stefan D. Anker, Dragana Kosevic, J. Eduardo Rame

Department of Medicine Faculty Papers

INTRODUCTION: Relationship between changes in cardiac function, functional capacity, and patient-reported health status in heart failure (HF) remains incompletely defined, which may help inform endpoint selection and clarify how distinct clinical domains reflect treatment response.

METHODS: This post hoc analysis of the randomized cardiac microcurrent (C-MIC) II trial, which evaluated the efficacy and safety of C-MIC therapy in patients with chronic HF with reduced ejection fraction on optimal guideline-directed medical therapy, included 65 ambulatory patients with non-ischaemic dilated cardiomyopathy, New York Heart Association (NYHA) Class III-IV symptoms, and baseline left ventricular ejection fraction (LVEF) 25-35%. Correlations between changes in Kansas …

Single-Layer Spherical (Sls) Vs Single-Layer (Sl) Woven Endobridge (Web) Device In The Treatment Of Narrow-Neck Intracranial Aneurysms: A Propensity Score-Matched Analysis, Hamza Adel Salim, Vivek Yedavalli, Fathi Milhem, Nimer Adeeb, Basel Musmar, Muhammed Amir Essibayi, Motaz Daraghma, Mahmoud Dibas, Nicole M. Cancelliere, Jose Danilo Bengzon Diestro, Oktay Algin, Sherief Ghozy, Sovann V. Lay, Adrien Guenego, Leonardo Renieri, Joseph Carnevale, Guillaume Saliou, Panagiotis Mastorakos, Kareem El Naamani, Eimad Shotar, Markus Möhlenbruch, Michael Kral, Charlotte Chung, Mohamed M. Salem, Ivan Lylyk, Paul M. Foreman, Hamza Shaikh, Vedran Župančić, Muhammad U. Hafeez, Joshua Catapano, Muhammad Waqas, Muhammet Arslan, Onur Ergun, James D. Rabinov, Julian Maingard, Clemens M. Schirmer, Mariangela Piano, Anna L. Kühn, Caterina Michelozzi, Robert M. Starke, Ameer Hassan, Mark Ogilvie, Anh Nguyen, Jesse Jones, Waleed Brinjikji, Marie T. Nawka, Marios Psychogios, Christian Ulfert, Bryan Pukenas, Jan-Karl Burkhardt, Thien Huynh, Juan Carlos Martinez-Gutierrez, Sunil A. Sheth, Diana Slawski, Rabih Tawk, Benjamin Pulli, Boris Lubicz, Pietro Panni, Ajit S. Puri, Guglielmo Pero, Eytan Raz, Christoph J. Griessenauer, Hamed Asadi, Adnan Siddiqui, Elad I. Levy, Neil Haranhalli, David Altschul, Andrew F. Ducruet, Felipe C. Albuquerque, Robert W. Regenhardt, Christopher J. Stapleton, Peter Kan, Vladimir Kalousek, Pedro Lylyk, Srikanth Boddu, Jared Knopman, Stavropoula I. Tjoumakaris, Hugo H. Cuellar-Saenz, Pascal M. Jabbour, Frédéric Clarençon, Nicola Limbucci, Vitor Mendes Pereira, Aman B. Patel, Max Wintermark, Adam A. Dmytriw

Department of Neurosurgery Faculty Papers

Data on the use of Woven EndoBridge (WEB) devices in the treatment of narrow-neck intracranial aneurysms (NNA) are limited. We compared the efficacy and safety of single-layer (SL) and single-layer spherical (SLS) WEB devices in treating NNA. We conducted a multicenter retrospective analysis of adult patients with NNA (neck ≤ 4 mm and width-to-neck ratio ≥ 2) treated with SL or SLS WEB devices between January 2011 and December 2022. Patients with fusiform or blister aneurysms, adjunctive treatments, or devices other than SL or SLS were excluded. Propensity score matching was used to adjust for confounding variables. Outcomes included procedural …

Sex Differences In The Association Between Childhood Cyberbullying Victimization And College Sexual Assault: Moderating Roles Of Parental Monitoring And Relationship With Deviant Peers, Jungup Lee, Debra Patterson, Na Youn Lee, Jinyung Kim, Stephen J. Tripodi, Hyunkag Cho

Faculty Research, Scholarly, and Creative Activity

This study explores sex differences in the relationship between childhood cyberbullying victimization (CCBV) and young adult sexual assault experiences and the potential moderating roles of childhood parent monitoring and deviant peer association on the relationship. A total of 356 college students aged 19–25 in the US participated in the online survey. The results indicated that CCBV was associated with an increased risk of college sexual assault victimization for both males and females. A significant moderating effect of childhood parental monitoring and deviant peer association was found between the association between CCBV and college sexual assault victimization for female students only.

Dynamic Deep Prompt Optimization For Defending Against Jailbreak Attacks On Llms, Doniyorkhon Obidov, Honggang Yu, Xiaolong Guo, Kaichen Yang

Michigan Tech Publications

Large Language Models (LLMs) demonstrate impressive capabilities across many applications but remain vulnerable to jailbreak attacks, which elicit harmful or unintended content. While model fine-tuning is an option for safety alignment, it is costly and prone to catastrophic forgetting. Prompt optimization has emerged as a promising alternative, yet existing prompt-based defenses typically rely on static modifications (e.g., fixed prefixes or suffixes) that cannot adapt to diverse and evolving attacks.

We propose Dynamic Deep Prompt Optimization (DDPO), the first jailbreak defense based on deep prompt optimization. DDPO uses the target LLM’s own intermediate layers as feature extractors to dynamically generate defensive …

Pd-L1 Positivity Predicts A Unique Hyperaggressive Tumor Group Within Meng C Meningiomas, Vijay Nitturi, Shervin Hosseingholi Nouri, Collin English, Hsiang-Chih Lu, Elizabeth Ledbetter, Diego Rojas, Sean Lau, Malcolm Mcdonald, Jacob J Mandel, Abdul Basit Khan, Arif O Harmanci, Akdes S Harmanci, Tiemo Klisch, Akash J Patel

Duncan NRI Faculty and Staff Publications

Molecular profiling has identified 3 groups of meningiomas, with MenG C tumors exhibiting the vast majority of recurrences. Efforts to find effective treatments for recurrent meningiomas have remained elusive. Higher WHO-grade meningiomas have exhibited greater Programmed Death Ligand 1 (PD-L1) expression through various methods, but the prognostic value of PD-L1 expression has not been described in the context of molecular profiling. Additionally, trials investigating PD-1/PD-L1-targeted immunotherapies have produced disappointing results. Here, we find that PD-L1 positivity, while prevalent in MenG C tumors, does not predict recurrence in the benign MenG A and B tumors. PD-L1 positivity also occurs independently of …