Digital Commons Network^™

Assessing Misidentification Potential When Using Percent Developmental Delay As An Early Intervention Eligibility Criterion, Allison Gladfelter, Sarah Thomas, Christine Nguyen, Sarah O'Connor

CISLL Publications

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Visdb 20: A Manually Curated Resource Of Viral Integration Sites And Their Regulatory Maps In Human Diseases, Citu Citu, Ajeet Singh, Xinyi Liu, Mounika Ashannagari, Rinki Ratnapriya, Zhongming Zhao

Faculty, Staff and Student Publications

The integration of viral sequence into the human genome plays critical role in the onset of various diseases, especially cancers. To facilitate systematic analysis of these events, we present VISDB 2.0, an expanded and updated database of human viral integration sites (VISs). The current release contains more than 270,000 manually curated VISs derived from 209 peer-reviewed publications, covering 11 viruses, including four retroviruses and seven DNA viruses. This represents a 3.5-fold increase in VIS entries compared with the previous version. Each VIS record includes standardized genomic coordinates and annotations describing local genomic context, CpG islands, repetitive elements, chromosomal fragile sites, …

Beyond Alumni Dollars: Developing Engagement With Graduate Alumni, Kyra J. Snyder

USF Tampa Graduate Theses and Dissertations

Alumni engagement plays an increasingly important role in supporting graduate program mission, reputation, and long-term sustainability. Despite its recognized value, limited research examines alumni engagement within graduate level programs from a practitioner perspective. The purpose of this study was to examine perceptions of alumni engagement among alumni, faculty, and staff within the University of South Florida (USF) Physician Assistant Program and to identify any needs or gaps in current engagement opportunities. This study employed a survey-based research design to gather data from two stakeholder groups from the USF PA Program: alumni and faculty/staff. A review of program records provided data …

2026 Clinical Practice Guideline Update By The Infectious Diseases Society Of America And The Pediatric Infectious Diseases Society On The Management Of Community-Acquired Pneumonia In Infants And Children Older Than 3 Months Of Age: The Use Of Tpa And Dnase Or Tpa Alone For Fibrinolysis, Shawn D St Peter, Krow Ampofo, Thomas Brogan, Michael D Cabana, Claudia Espinosa, Todd A Florin, Jeffrey S Gerber, Michelle Gill, Debra L Palazzi, Mark Sawyer, Angela M Statile, Derek J Williams, Sheena Patel, Mark I Neuman, Samir S Shah

Faculty, Staff and Students Publications

This paper is part of a larger clinical practice guideline on the diagnosis and management of parapneumonic effusion and empyema in children, developed by the Pediatric Infectious Diseases Society and the Infectious Diseases Society of America. In this report, the panel provides recommendations for intrapleural fibrinolysis with tissue plasminogen activator (tPA) alone over tPA and dornase alfa (DNase) in children (3 months to 18 years) with complicated parapneumonic effusion and empyema. The panel's recommendations are based upon evidence derived from systematic literature reviews and adhere to a standardized methodology for rating the certainty of evidence and strength of recommendation according …

Multimodal Imaging Reveals A Lysosomal Drug Reservoir That Drives Heterogeneous Distribution Of Parp Inhibitors, Carmen R Moncayo, Lauren Pendergast, Priyanka Verma, Et Al.

2020-Current year OA Pubs

For all drugs, effective target engagement requires sufficient intracellular concentrations of drug to be reached, but whether tumour heterogeneity impacts drug distribution and efficacy is poorly studied. Poly (ADP-ribose) polymerase (PARP) inhibitors have transformed treatment opportunities for women with high-grade serous ovarian carcinoma, but resistance remains a clinical hurdle in this highly heterogeneous tumour type. Here, we present a patient-derived explant multi-modal imaging pipeline, which demonstrates that cell-intrinsic PARP inhibitor accumulation is highly variable, both between patients and within tumours. Spatial transcriptomics reveals enrichment of apoptotic and lysosomal signatures in high-drug regions. Rucaparib, an intrinsically fluorescent PARP inhibitor, accumulates heterogeneously …

Factors Associated With Telemedicine Use By Cardiologists For Medicare Beneficiaries In 2022 To 2023: An Observational Study, Samantha Harris, R J Waken, Fengxian Wang, Khavya C Avula, Rishi K Wadhera, Jose F Figueroa, E John Orav, Uchenna Ofoma, Karen E Joynt Maddox

2020-Current year OA Pubs

BACKGROUND: During the COVID-19 pandemic, the Centers for Medicare and Medicaid Services created a waiver to reimburse telemedicine services. It is important to understand factors that facilitate incorporation of telemedicine into ongoing cardiovascular practice.

METHODS: This was a retrospective cohort study of telemedicine and office visits delivered by cardiologists between January 1, 2022, and December 31, 2023, for Medicare beneficiaries. We calculated the adjusted incidence rate ratio (aIRR) of telemedicine visits, representing the proportion of a physician's visits delivered by telemedicine, to identify factors associated with telemedicine use.

RESULTS: There were 23 334 physicians in our cohort; they were predominantly …

Dexmedetomidine On Supraventricular Tachycardia In Critical Illness: A Time-Dependent Propensity Score Matching Study, Qiaonan Zhong, Marin H Kollef, Patrick G Lyons, Andrew P Michelson

2020-Current year OA Pubs

BACKGROUND: Supraventricular tachycardia affects many critically ill patients. Dexmedetomidine, a commonly used sedative, has sympatholytic and vagotonic effects that may alter atrioventricular nodal conduction and contribute to SVT. We aim to determine the association between dexmedetomidine exposure and clinically significant supraventricular tachycardia in a heterogeneous cohort of mechanically ventilated, critically ill adults. METHODS: This retrospective cohort study included critically ill patients from 11 hospitals admitted between July 2018 and October 2022, who were intubated within 48 h of admission. The primary exposure was intravenous dexmedetomidine. The primary outcome was occurrence of clinically significant supraventricular tachycardia, defined as heart rate > 100 …

Avian Influenza Preparedness In Ghana: A Cross-Sectional Assessment Of Knowledge, Attitudes, And Practices Among Residents Of Nsawam-Adoagyiri Municipality, Eastern Region, Christopher Yaw Dumevi, George Boateng Kyei, Et Al.

2020-Current year OA Pubs

BACKGROUND: Avian influenza (AI) represents a persistent threat to public health, food security, and livelihoods in Ghana, where outbreaks of H5N1 and H9N2 have occurred. This cross-sectional study evaluated the knowledge, attitudes, and practices (KAP) related to avian influenza among residents of the Nsawam-Adoagyiri Municipality; an area characterized by intensive poultry production with the aim of delineating deficits in community-level preparedness and guiding evidence-based public health interventions. METHODS: A community-based cross-sectional study was conducted from May to July 2025 using a four-stage sampling technique. We surveyed 321 adults via structured questionnaires, evaluating socio-demographics and KAP related to AI. Scale reliability …

Sequential Transformation Of Polycythemia Vera To Myelofibrosis And Kmt2a-Rearranged Acute Myeloid Leukemia Treated With Revumenib: A Rare Case Of Clonal Evolution, Christopher M. Ahmad, Rae-Anne Kastle, Lara Zargarian, Yasmeen Sawalha, Samir Dalia

Student Publications

Transformation of polycythemia vera (PV) into post-polycythemic myelofibrosis (MF) and subsequently acute myeloid leukemia (AML) represents one of the most aggressive trajectories among myeloproliferative neoplasms (MPNs). Post-MPN AML carries a median survival of approximately six months, particularly among older adults with adverse cytogenetics. We report the case of a 73-year-old man with JAK2-positive PV diagnosed in 2020 who progressed to MF in 2024 and developed AML later that year. Cytogenetic analysis revealed a KMT2A (11q23) rearrangement with KMT2A::ELL fusion, a finding rarely described in secondary AML arising from MPNs. Due to advanced age, transfusion dependence, and significant cardiovascular comorbidities, the …

Using Mobile Devices To Support Outdoor Stem Learning In Rural Contexts: An Embedded Mixed-Methods Study, Jayson Seaman, Amanda Bastoni, Andrew D. Coppens, Cindy L. Hartman, Courtney Lachaine, Katelyn Moscouver, Janet Gronneberg

Faculty Publications

Background: Rural youth face barriers to involvement in effective Science, Technology, Engineering, and Math (STEM) learning experiences, leading to persistent underrepresentation in STEM fields. Purpose: This study examined the feasibility of using mobile devices to engage rural youth in informal STEM learning (ISL) during free-choice, outdoor recreational activities. We assessed outcomes of a 10-month intervention related to STEM interest, identity, and future planning. Method: Fifty-four youth ages 12 to 17 completed monthly STEM challenges delivered via a mobile platform, aligned with connected learning and free-choice learning principles. Surveys measured pre/post changes in STEM supports, STEM confidence, and …

2026 Clinical Practice Guideline Update By The Infectious Diseases Society Of America And The Pediatric Infectious Diseases Society On The Management Of Community-Acquired Pneumonia In Infants And Children Older Than 3 Months Of Age: The Choice Of Chest Tube Size, Shawn D St Peter, Krow Ampofo, Thomas Brogan, Michael D Cabana, Claudia Espinosa, Todd A Florin, Jeffrey S Gerber, Michelle Gill, Debra L Palazzi, Mark Sawyer, Angela Statile, Derek J Williams, Sheena Patel, Mark I Neuman, Samir S Shah

Faculty, Staff and Students Publications

This paper is part of a larger clinical practice guideline on the diagnosis and management of parapneumonic effusion and empyema in children, developed by the Infectious Diseases Society of America. In this paper, the panel provides recommendations on the appropriate size of thoracostomy tube for drainage. The panel's recommendations are based upon evidence derived from systematic literature reviews and adhere to a standardized methodology for rating the certainty of evidence and strength of recommendation according to the GRADE (Grading of Recommendations Assessment, Development, and Evaluation) approach.

03-17-26 Bor Hsc Committee Meeting Agenda, Patricia Serna

HSC Committee (A subcommittee of the UNM Board of Regents)

03-17-26 BOR HSC Committee Meeting Agenda

Regression Dressed As Reform: Bharatiya Nyaya Sanhita And The Shifting Contours Of Political Speech, Anushka Singh

National Law School of India Review

This paper examines the shifting contours of criminal law in relation to political speech, with a focus on Section 152 of the Bharatiya Nyaya Sanhita (BNS). It advances three arguments. First, the decolonising narrative behind deleting sedition glosses over substantive continuities between colonial and post-colonial periods, with Section 152 BNS refashioning the colonial-era bifurcation between ‘sedition’ and ‘sedition-like’ activity. The BNS provision represents a backslide in the way it converges the various legal and political connotations of sedition from colonial to contemporary times, creating a new criminal category constructed through popular political-extra-legal discourses. Second, Section 152 BNS borrows from the …

Lessons Learned: Ignazio Visco, Mercedes Cardona

Journal of Financial Crises

Ignazio Visco served as deputy director general (the equivalent of deputy governor) of the Bank of Italy during the Global Financial Crisis of 2007–09 (GFC) and as governor during the European Sovereign Debt Crisis in 2011 (SDC). During his multidecade tenure at the bank, he held several positions and served under nine prime ministers before stepping down in 2023. Although Italy had the third-largest economy in the eurozone, its banking sector had little exposure to mortgages, which resulted in its being somewhat less impacted by the GFC than other countries. However, the SDC had a severe impact. With the assistance …

Lessons Learned: Masaaki Shirakawa, Mercedes Cardona, Benjamin Hoffner

Journal of Financial Crises

Masaaki Shirakawa became governor of the Bank of Japan (BOJ) in 2008, after a long tenure at the central bank. His career spanned a series of significant crisis events in Japan’s economic history, including the economic boom in the 1980s, which was followed by a period of stagnation characterized by low GDP growth, multiple recessions, and persistent deflation. Shirakawa led the BOJ’s response during the Global Financial Crisis of 2007–09 (GFC). He also initiated the central bank’s contingency plan in response to the 2011 tsunami, earthquake, and Fukushima nuclear disaster before stepping down near the end of his term in …

Lessons Learned: Eugen Rădulescu, Benjamin Hoffner

Journal of Financial Crises

Eugen Rădulescu has worked at the National Bank of Romania (NBR) since 1990 in various roles covering monetary policy, foreign exchange, and supervision. During his tenure, he contributed to the NBR’s work to fortify Romanian’s post-communist banking laws and the operational structure of its financial system to bring it up to the European standard, enabling Romania to join the European Union (EU) in 2007. Following the Global Financial Crisis of 2007–09 (GFC), Rădulescu was named director of the NBR’s Financial Stability Department and has served in this role until June 2023,when he became senior adviser to the governor of the …

Black Swans And Financial Stability: A Framework For Building Resilience, Daniel J. Barth, Stacey L. Schreft

Journal of Financial Crises

This article refines the concept of black swans, typically described as highly unlikely and catastrophic events, to be internally consistent. It explores features of the financial system that prevent the eradication of black swans. The main implication is the need to enhance the financial system’s resilience to withstand unforeseen events rather than focus on past crises. The article introduces a “resilience principle” for designing official-sector policies that can achieve such goals. The principle calls for policies that are adaptable, universal, and systemic. The article provides examples of policies with these features, assuming that the official sector is not better positioned …

How The Fdic Sourced Crisis-Time Fed Funding Through The Failed Banks Of 2023, Steven Kelly

Journal of Financial Crises

During the Banking Crisis of 2023, the Federal Deposit Insurance Corporation (FDIC) had to contend with the liquidity demands of the second-, third-, and fourth-largest bank failures in US history, all in a compressed timeframe. Facing uncertainty over its liquidity needs, particularly if additional banks were to fail, and optics and political challenges over accessing its standing credit lines with the Treasury—which itself was brushing against the federal debt ceiling—the FDIC relied on two creative forms of financing itself. First, the agency kept open the Federal Reserve (Fed) loans taken on by the failed banks, eschewing its standard practice of …

Settler Colonialism: A Case-Study Analysis Of Dam Infrastructure In The American West, Kassidy Haynes, Carrie Mott

The Cardinal Edge

In 17^th-century North America, a number of world powers began extensive colonial efforts to stake a claim on territories and their resources. Settler colonialism in the United States followed a distinct track to the west compared to that which occurred in the east following this initial land-grab. Because infrastructure preceded some formal, highly concentrated settlement in the western United States, this region experienced the oppression of settler colonialism in distinct manifestations. Namely, the physical imposition of construction projects such as dams established early dynamics of differential power and control between the federal government and the diverse array of …

Aristotle And The Proslavery Writings Of The Antebellum South, Ace Farris

The Cardinal Edge

This paper explores how nineteenth-century Southern intellectuals appropriated and adapted Aristotle’s ancient defense of slavery to legitimize racial slavery in the antebellum United States. Although Aristotle’s theory of “natural slavery” emerged from the social and economic conditions of classical Greece, where enslaved people constituted essential components of the household, Southern thinkers tailored his argument to justify the peculiar institution. The paper begins by outlining Aristotle’s defense of slavery in his Politics, which states that some individuals naturally lack the capacity for rational deliberation, thereby benefiting from enslavement. Then, it traces how the American South’s investment in classical education allowed …

Fear And Freedom: California Gay Bars In The 1960s, Bridget L. Kelley

The Cardinal Edge

This article explores the interactions between gay bars, queer people, and police in California in the 1960s. The gay bar served as both a place of community and safety while paradoxically being a site of oppression suffered at the hands of law enforcement. These conflicting experiences made gay bars sites of both fear and freedom. Arrest practices, plain clothes policing, raid practices, and monetary manipulation made the gay bar a space of danger. However, the resistance of queer patrons against police brutality made it a space where one could express their queerness and fight for change.

Making A Victim: The Quest To Define Austria In A Cold War Context, Katherine E. White

The Cardinal Edge

When the Second World War concluded, the Allied Powers were left with the complicated question of how to deal with the territories that they had occupied on their march to Berlin. Of all the territories conquered by Germany under Nazi rule, Austria proved to be one of the most difficult and polarizing to define. It towed the line between victim and accomplice, having endorsed its own annexation to Germany in 1938. For ten years after the war’s end, the Allied Powers occupied Austria, locked in a stalemate over the country’s fate. This paper examines how the various occupying powers, in …

The Kennedy Familys' Influence On The Passage Of The Immigration And Nationality Act Of 1965, Jillian Wallshield

The Cardinal Edge

This paper covers the influence of the Kennedy Family on immigration policy in the United States. United States immigration legislation changed dramatically in the 1960s with the passage of the Immigration and Nationality Act of 1965 (sometimes called the Hart-Cellar Act). This shift was caused primarily by the political work of prominent figures like John F. Kennedy, and, later, Edward Kennedy. Edward Kennedy in particular is examined through his influence on Lyndon B. Johnson, the President under which the Immigration and Nationality Act was passed. This position is supported through the examination of relevant public speeches, private telephone calls, and …

Hallucinogens For Mood And Anxiety Disorders: A Critical Review Of Psychedelic-Assisted Therapies, Georgia Chlebek

The Cardinal Edge

In quite a few people worldwide, there are several mental disorders that prevent the brain from operating in the “proper” way, depression, anxiety, and post-traumatic stress disorder (PTSD) being among the most common. Luckily, there are several medications that are produced and used to treat these disorders, but some medications are hard to access, and others simply don’t help the patient. Firstly, these medications take time to study and prove safe for public use, though in some cases time is not readily available. In other cases, these medications are going through shortages and becoming increasingly difficult for patients to access …

Determination Of Trace Amounts Of Pb2+ And Cu2+ Ions In The Ohio River With Anodic Stripping Voltammetry And Flame Atomic Absorption Spectroscopy To Test Water Contamination From Factories., Eliana Purcell

The Cardinal Edge

In this project, water near factories in Rubbertown, Louisville, KY were tested to see if a significant enough amount of waste is deposited in the Ohio River that the concentrations of Pb2+ and Cu2+ exceed the maximum contaminant levels the World Health Organization (WHO) and the United States Environmental Protection Agency (EPA) have set in place. Waste from industrial factories may contain contaminants that have negative effects on aquatic ecosystems and even human health, so two potentially harmful metal ions were tested. The concentration of Cu2+ in water samples was detected through flame atomic absorption spectroscopy (FAAS), and the concentration …

Asimina Triloba (L.) Dunal: The Complete Story Of America’S Forgotten Fruit, Autumn M. Howard

The Cardinal Edge

Asimina triloba, commonly known as the pawpaw, is a unique and historically significant native fruit tree of the eastern United States. This research paper explores the taxonomy, botanical description, distribution, habitat requirements, ecological interactions, economic importance, and reproductive biology of A. triloba. The species is distinguished by its tropical-flavored fruits, adaptation to temperate climates, and reliance on clonal reproduction and specific insect pollinators. While offering promising opportunities for sustainable agriculture and riparian restoration, A. triloba faces challenges related to limited seed dispersal, susceptibility to certain pests and diseases, and the presence of neurotoxic compounds. Despite its historical importance …

Development And Preliminary Pressure Control Validation Of Woundwatch: Npwt System With Remote Monitoring Capabilities, Swetha Senthil Nathan

The Cardinal Edge

Chronic wounds, including diabetic foot ulcers, pressure sores, and venous leg ulcers, affect over 40 million individuals worldwide and are often complicated by delayed healing due to limited access to continuous monitoring. Negative Pressure Wound Therapy (NPWT) is an established treatment that promotes wound healing through controlled sub-atmospheric pressure. However, conventional NPWT systems lack real-time physiological feedback and require frequent in-person follow-ups, limiting their effectiveness in remote or low-resource settings. This study presents WoundWatch, a portable, low-cost NPWT device that integrates real-time temperature, humidity, and pressure sensing with wireless data transmission via an IoT platform. The system includes a vacuum …

Lamin A/C And Linc Complex Expression Affects Nuclei's Mechanical Properties And Functions In Osteosarcoma, Shridha Rajeswar

The Cardinal Edge

The nucleus has long been simplified in the field of biology, despite being an important organelle. Until recently, it has been commonly depicted as a simple sphere located at the center of a cell, responsible mainly for regulating protein synthesis. However, current research indicates that the linkers of the nucleoskeleton and cytoskeleton (LINC) complexes, the pillars of nuclear architecture, play a critical role in maintaining nuclear integrity and function. These complexes interact with proteins, such as Lamins, that modulate responses to biomechanical stimuli through the regulation of gene expression. As such, when these structures are downregulated, they can contribute to …

The Silent Epidemic: How E-Cigarettes And Policy Gaps Endanger Public Health, Fizzah Syed, Saumya Sikhwal, Priya Viswakumar

The Cardinal Edge

No abstract provided.

Sound, Speech, And Synapses: Rebuilding The Brain Through Neuroplasticity, Sireen Khader

The Cardinal Edge

No abstract provided.