Digital Commons Network^™

Green Value Chain Analysis And Its Role In Improving Resource Allocation Decisions: A Case Study In Diwaniya Dairy Factory, Ail Abdul-Hussein Hani Al-Zameli, Nabaa Duaa Fakher

Muthanna Journal of Administrative and Economics Sciences

The purpose of this study is to justify the role of The green value chain as a modern technique of management accounting in facilitating investment decisions and optimizing the effectiveness in resources utilization at industrial units. The premise underlying the study is that green value serves as a frame of reference for analysing activities, which in turn allows to separate value-adding from non-value adding ones, leading to cost reduction and environmental soundness. Management is also not about finding faults for waste and allocating funds, it's all about tapping new ways of creating value by eliminating non-value adding activities. The deductive …

Application Of A Fuzzy Multi-Objective Defuzzification Method To Solve A Multi-Modal Transportation Problem, Qusay H Khalaf, Khalid Zeghaiton Chaloob

Muthanna Journal of Administrative and Economics Sciences

Multi-modal transportation systems are the logistics networks for global economy. Transportation systems are fraught with uncertainties that hinder the traditional deterministic models reaching the optimal performance. The main obstacle for traditional deterministic models is the uncertainties (e.g., fuel prices volatility, inaccurate transit-times prediction, and evolving environmental regulations). This paper proposes a novel method of fuzzy multi-objective defuzzification. It integrates a modified center of gravity (COG) technique with multi-objective linear programming (MOLP) to address the uncertainty challenges. Triangular fuzzy numbers and partitioning to sud-intervals generated crisp solutions to balance conflicting objectives: cost, time, and environmental sustainability. A four transportation-mode used as …

The Role Of Transformable Facade Technologies In Enhancing The Architectural Environment Quality In Educational Buildings, Waad Marawan Elashry, Ahmed Eltantawy Elmaidawy, Esraa Elazab

Mansoura Engineering Journal

In recent times, Educational Buildings development has become an increasingly important issue at all locations, even in the areas with the least means. Progress in the field of technology has impacted the development of architecture and modern technologies have provided for the architect enormous possibilities in the formation and design of buildings. The facade of a building plays a crucial role in providing environmental comfort, depending on the type of envelope and design. Architects and engineers need to consider many issues when working with facade designs, including environmental issues, aesthetic appearance, comfort of building occupants, and the view; these aspects …

Developing A Novel Index For Neighborhood Social Determinants Of Cardiovascular Diseases In The Cardia Study, Tao Gao, Yinan Zheng, Brian T Joyce, Lei Liu, Lili Liu, Catarina Kiefe, Sarah Forrester, Penny Gordon-Larsen, Chunyu Liu, Donald Lloyd-Jones, Kai Zhang, Lifang Hou

2020-Current year OA Pubs

Neighborhood social determinants of health have been shown to influence cardiovascular risk and the development of cardiovascular disease, but few studies have been done about early-life exposure as well as the combined effect of multiple neighborhood social determinants of health measures. Each 1-standard-deviation increase in the neighborhood social determinants of health index is associated with increased risk of coronary artery calcification at the year 7, year 15, and year 20 visits (Odds Ratios range from 1.15 to 1.17). The area under the Receiver Operating Characteristics curve ranges between 0.718 (year 7) and 0.719 (year 20). Compared to White participants, Black …

Developing Empathy In Middle And High School Adult Educators Within Multicultural Contexts, Warren M. Grimm

Electronic Theses and Dissertations Archive

This qualitative study examined how school-based professional development reflection programs influence teachers’ empathy across cultural differences within an independent school context. Grounded in Multicultural Theory and scholarship on empathy, the study explored how structured, sustained reflective practices shape educators’ understanding, relational engagement, and collective organizational culture. The problem of practice addressed in this study was the need for independent school leaders to cultivate culturally responsive environments within limited time and resource constraints, while serving increasingly diverse school communities. Using a qualitative design, data were collected through in-depth interviews with educators who participated in a structured, research-based reflective professional development program. …

Spacecube: Interactive Real-Time Uas Hyperspectral Processing, Thomas Pascarella Watson

Electronic Theses and Dissertations Archive

Hyperspectral cameras capture hundreds of data points per sample (pixel), thereby providing numerous advantages in remote sensing tasks. Many tasks can be effectively conducted with such a camera mounted on a small uncrewed aerial system (sUAS). However, obtaining results traditionally requires significant post-processing of captured data after flight, delaying insight. To mitigate the delay, this work proposes Spacecube, a program that implements a complete interactive hyperspectral processing pipeline. Spacecube's novel inverse georectification algorithm processes entire datasets in seconds, compared to hours for traditional methods, and eliminates pixel coverage artifacts. This allows immediate high-quality viewing and adjustment of captured flight data. …

Organic Management Of Pillbugs And Sowbugs In Strawberries And Other Fruits, Briger Carey, Marion Murray, Emilie Demard, Jennifer R. Reeve

All Current Publications

Pillbugs and sowbugs are collectively known as isopods that typically feed on soil organic matter, but under certain conditions, they can be a pest of many young plants and berries. This fact sheet reviews identification, life cycle, damage, and organic management strategies for pillbugs and sowbugs.

Pseudomonas Aeruginosa: A Rare Cause Of Necrotizing Fasciitis, Carrine S. Kogulan, Oluwafemi Ajibola

Student Publications

Necrotizing fasciitis (NF) is a rare but life-threatening soft tissue infection characterized by rapid progression, systemic toxicity, and high mortality. While Group A Streptococcus is the most common pathogen, Pseudomonas aeruginosa is an uncommon cause, typically reported in immunocompromised patients.

We present the case of a 77-year-old male with chronic lymphocytic leukemia (CLL), chronic kidney disease, and other comorbidities who initially presented to an outside facility with three days of fever and left lower extremity pain. He was admitted with presumed cellulitis, and blood cultures grew Pseudomonas aeruginosa. Despite appropriate antibiotic therapy with vancomycin and ceftriaxone, the patient developed …

Neutrosophic Probability With Dynamic Temporal Uncertainty (Nptu), Bhimraj Basumatary, Ashoke Kumar Brahma

Neutrosophic Systems with Applications

This paper introduces Neutrosophic Probability with Dynamic Temporal Uncertainty (NPTU), an extension of classical neutrosophic probability that incorporates the dimension of time. In classical neutrosophic probability, the degrees of truth, indeterminacy, and falsity are considered static. However, real-world uncertainties evolve, and their degrees change as new information becomes available. NPTU models these uncertainties dynamically, allowing for more accurate decision-making in time-varying environments. The paper explores key mathematical properties of NPTU, including entropy, distance measures, similarity measures, and Kullback-Leibler (KL) divergence, to quantify and compare temporal uncertainty states. The proposed framework is demonstrated through a case study on stock price prediction, …

Double-Valued Complex Neutrosophic Graphs, Suriyakumar G, V. J. Sudhakar, Takaaki Fujita

Neutrosophic Systems with Applications

This paper introduces a novel graph-theoretic framework, called the double-valued complex neutrosophic graph, as an extension of double-valued neutrosophic set theory. Within this framework, we investigate several important classes of such graphs, including self-complementary, strong, and full double-valued complex neutrosophic graphs, and establish a number of their fundamental properties. To clarify the proposed concepts and demonstrate their structural behavior, several relevant illustrative examples are also provided.

Bifurcation Exploration Of Ion Acoustic Solitons Formation Of A Nonlinear Beta Fractional Kadomtsev-Petviashvili Burger Model In Plasma State, Mst. Razia Pervin, Alrazi Abdeljabbar, Fahad Sameer Alshammari, Mst. Shekha Khatun, Harun Or-Roshid

Mathematical Modelling and Numerical Simulation with Applications

This research presents an extensive investigation of Ion acoustic soliton dynamics governed by a Beta-fractional Kadomtsev-Petviashvili-Burgurs (KPB) model. By engaging the planar dynamical system scheme in aggregation with the extended $(\phi, \psi)$ expansion, Kudryashov expansion, and the NMKM analytic schemes, we create a broad class of exact nonlinear pattern wave solutions. The local stability edifice of the fractional plasma model is explored through bifurcation theory, enabling the far-reaching classification of all admissible phase diagrams. Conforming Ion acoustic wave structures allied with every detour alignment are systematically assembled. Owing to the fractional and dissipative appearances of the model, an all-embracing assortment …

Numerical Simulations And Hyers-Ulam Stability Of A Novel Nonlocal Anthropogenic Cutaneous Leishmaniasis Mathematical Model, Khalid Fanoukh Al Oweidi, Zakirullah -, Kamal Shah, Thabet Abdeljawad

Mathematical Modelling and Numerical Simulation with Applications

In this work, the fractal-fractional Atangana-Baleanu derivative with the Mittag-Leffler kernel is employed to capture the memory and hereditary effects inherent to anthropogenic cutaneous leishmaniasis transmission dynamics. The Banach fixed-point theorem and contraction mapping principle are used to prove the existence and uniqueness of solutions, while Hyers-Ulam stability of the system is analyzed to demonstrate the robustness of solutions with respect to small perturbations. Using a nonlinear least-squares approach, model parameters and fractional order are estimated using epidemiological data from the World Health Organization. The basic reproduction number $R_0 = 0.53$ indicates that the disease is under control after adding …

Optimal Control And Bifurcation Analysis Of A Predator–Prey Model With Self-Limiting Growth And Predator Disease, Dipo Aldila, Muhammad Akmal Fasya, Bevina D. Handari, Chidozie Williams Chukwu, Olumuyiwa James Peter

Mathematical Modelling and Numerical Simulation with Applications

We propose and analyze an eco-epidemiological predator–prey model that incorporates self-limitation and disease transmission within the predator population. The model is formulated as a system of ordinary differential equations describing logistic prey growth under the interspecific interaction with the predator. On the other hand, the predator population is divided into susceptible and infected classes, whose growth is constrained by prey availability. Three biologically relevant equilibria are identified: predator extinction, disease-free coexistence, and coexistence with endemic disease. The existence and stability of these equilibria are determined by key ecological and epidemiological thresholds, including the basic reproduction number. Using numerical continuation methods, …

Measuring Market Risk Through Entropic Var, Dragomir Nedeltchev, Tsvetelin Zaevski

Mathematical Modelling and Numerical Simulation with Applications

The article aims to measure the market risk beyond the basic risk measures like the Value-at-Risk (VaR) and the Expected Shortfall (ES). The Entropic Value-at-Risk is selected among the available measures based on its advantages -- it is the coherent upper bound of the VaR and ES. This risk measure is applied to the classical Black-Scholes model as well as to some more realistic ones, such as the exponential tempered stable model (the log-returns are presented by a tempered stable L\'evy process), the stochastic volatility model of Heston, its jump extension of Bates, and another stochastic volatility model but with …

Free Versus In Situ Right Internal Mammary Artery As A Conduit In Coronary Artery Bypass Surgery: A Meta-Analysis, Yuta Kikuchi, Tomoki Sakata, Tomonari Shimoda, Shinichi Fukuhara, Junichi Shimamura, Makoto Hibino, Tsuyoshi Kaneko, Hiroo Takayama, Hisato Takagi, Michel Pompeu Sa, Toshiki Kuno

Department of Medicine Faculty Papers

OBJECTIVES: There is debate regarding the optimal choice for a second conduit in coronary artery bypass grafting. The right internal mammary artery (RIMA) is commonly employed as a second conduit; however, it is unclear whether the free (fRIMA) or in situ (isRIMA) configuration yields superior outcomes. We performed a systematic review and meta-analysis to compare clinical outcomes between fRIMA and isRIMA as the second conduit.

METHODS: A comprehensive search of PubMed (MEDLINE), EMBASE, and CENTRAL was performed through May 2025 to identify studies comparing outcomes in patients undergoing coronary artery bypass grafting with either fRIMA or isRIMA as a second …

Toxicity, Chemistry, And Public Health Relevance Of Emerging Nicotine Analog Vapes, Pods, And Pouches., Rhea Raghu, Mohana Sengupta, Karen Lin, Felix Effah, Robert M. Strongin, Irfan Rahman

Chemistry Faculty Publications and Presentations

Electronic nicotine delivery system manufacturers, such as Charlie's Holdings Inc., ECBlend, Outlaw, and NicRiver, have recently introduced nicotine analogs, such as 6-methyl nicotine, 6-MN ("Metatine"), and nicotinamide, NA ("Nixamide," "Nixodine," or "Nixotin-free base and salt") in products to circumvent the U.S. FDA's premarket tobacco product application (PMTA) requirements. Marketed as "tobacco-free," "PMTA-exempt," or "FDA-approved," these compounds now appear in oral nicotine pouches and disposable bars/vapes from brands such as Outlaw Dip, Kumi-Six, SBX, Katchmi, and Spree Bar under proprietary labels including "NoNic6," "Metatine," or "NIC-SAFE." These products often mimic the appeal of conventional nicotine delivery systems, with extensive use of …

Collaborating To Create A Research Training Program For Underrepresented Students: Insights And Strategies For Developing And Sustaining A Multi-Institutional Consortium, Mackenzie J. Gray, Dara Shifrer, De’Sha S. Wolf, Olivia M. Ainsworth, Rosemary A. Fama, Roberto P. Anitori, Ernest Blackwell, Tracey K. Burke, Carlos J. Crespo, Derek Helsham, Travis Kibota, Alissa Leavitt, Beylul Solomon, Thomas E. Keller

Sociology Faculty Publications and Presentations

Introduction

In 2014, the National Institutes of Health (NIH) invested in the Building Infrastructure Leading to Diversity (BUILD) initiative to enhance diversity in the biomedical research workforce. As one of ten grantees nationwide, the BUILD EXITO project at Portland State University established an institutionally and geographically diverse consortium including local community colleges, a research-intensive medical institution, and universities and community colleges around the Pacific Rim. The goal of this collaboration was to support comprehensive research training for undergraduates from backgrounds historically underrepresented in the biomedical workforce. This manuscript aims to provide insights into creating and sustaining a large-scale multi-institutional consortium.MethodsUsing …

High-Power Dual-Channel Chamber For High-Frequency Magnetic Neuromodulation, Xiaoyang Tian, Hui Wang, Boshuo Wang, Jinshui Zhang, Dong Yan, Jeannette Ingabire, Samantha Coffler, Guillaume Duret, Quoc-Khanh Pham, Gang Bao, Junzhe Wang, Ashok Veeraraghavan, Jacob T Robinson, Stefan M Goetz, Angel V Peterchev

Faculty, Staff and Students Publications

Objective. Several novel methods, including magnetogenetics and magnetoelectric stimulation, use high frequency alternating magnetic fields to precisely manipulate neural activity. To quantify the behavioral effects of such interventions in a freely moving mouse, we developed a dual-channel magnetic chamber, specifically designed for rate-sensitive magnetothermal-genetic stimulation, and adaptable for other uses of alternating magnetic fields.

Approach. Through an optimized coil design, the system allows independent control of two spatially orthogonal uniform magnetic fields delivered at different frequencies within a 10 × 10 × 6 cm3 chamber suitable for mouse studies. The two channels have nominal frequencies of 50 and 550 kHz …

Feasibility Of High-Intensity Interval Training In Older Adults With Hiv And Co-Occurring Hypertension, Michael J Hankes, Taylor L Taylor, Emily L Zumbro, Ene M Enogela, Fitzgerald Dodds, Mckenna Tharpe, Silvienne C Sint Jago, Burel R Goodin, Amanda L Willig, Thomas W Buford, Raymond Jones

2020-Current year OA Pubs

BACKGROUND: As life expectancy for people living with HIV (PWH) has increased, there has been a rise in age-related comorbidities such as hypertension. Exercise is an important nonpharmacological strategy to counter such adverse effects of chronic HIV infection. High-intensity interval training (HIIT) has been demonstrated to be safe and efficacious in improving health outcomes in individuals with chronic illness, but data are limited in older PWH and co-morbid conditions. The primary objective of this pilot feasibility study was to assess the feasibility, efficacy, and safety of a 6-week HIIT intervention among older PWH and co-occurring hypertension.

METHODS: PWH were recruited …

From Reclamation To Restoration: Remaking Nature On Portland's Peninsula, Theus Richards

University Honors Theses

This environmental history of the North Portland Peninsula is a critical case study of a landscape in transition, where new "natures" have been constructed through shifting projects of reclamation and restoration. The Port of Portland, who controlled the Peninsula, transformed the marshy bottomlands near the confluence of the Columbia and Willamette Rivers to accommodate greater networks of industrial infrastructure and expand their capacity for global trade. Beginning in 1967, the Port began dredging operations to fill Ramsey Lake to make way for the construction of Rivergate Industrial District. Through this process, Smith & Bybee Lakes were set aside as a …

Non-Javanese Speakers’ Perception Toward Javanese Language In Denny Caknan’S Ambyar Songs, Ryan Fauzi

Journal of Language, Literature, and Arts

Language plays a significant role in shaping meaning and influence in song lyrics. Denny Caknan’s Ambyar songs, which predominantly use the Javanese language, have attracted a wide audience, including non-Javanese speakers. This study aims to identify the linguistic aspects in the lyrics that appeal most to non-Javanese listeners and to examine how these songs influence their understanding of the Javanese language. A descriptive qualitative method was employed to obtain detailed and accurate findings. Data were collected through questionnaires distributed to non-Javanese speakers, consisting of both descriptive and multiple-choice questions. The results reveal that pure Javanese expressions, code mixing, and rhyme …

The Representation Of Bisexuality In Avatar: The Rise Of Kyoshi By F. C. Yee, Abdurrafi Nugraha Putra, Mochamad Ilham, Supiastutik Supiastutik

Journal of Language, Literature, and Arts

LGBT identities are often perceived as deviant within society; however, their representation has increasingly appeared across various media, including films, novels, and music. This study examines the representation of bisexuality in Avatar: The Rise of Kyoshi by F. C. Yee*. The data are drawn from narrative elements that reflect bisexual themes and are analyzed using Stuart Hall’s theory of representation, supported by Eve Kosofsky Sedgwick’s concept of homosocial desire. The findings show that bisexuality is represented through Kyoshi’s relationships with two characters: Yun (male) and Rangi (female). These relationships develop through three phases: heterosexual, homosocial, and homosexual. The interaction between …

Editor’S Introduction, Michael D. Pante

Philippine Studies: Historical and Ethnographic Viewpoints

No abstract provided.

Sexual Behavior Transitions Among Transgender Women In Indonesia: Insights From Palembang City And Banyuasin District, South Sumatra, Rico Januar Sitorus, Misnaniarti Misnaniarti, Novrikasari Novrikasari, Beka Purnama, Merry Natalia Panjaitan

Media Kesehatan Masyarakat Indonesia

Despite ongoing HIV prevention efforts, risky sexual behavior among transgender women remains a major public health concern in Indonesia. However, limited evidence is available regarding the determinants of sexual behavior among transgender women. This study aimed to analyze the main determinants influencing sexual behavior among transgender women in Palembang City and Banyuasin Regency, South Sumatra, Indonesia. A quantitative ap-proach with a cross-sectional design was employed, involving 233 transgender women. Sampling was conducted using the Time Loca-tion Sampling (TLS) method in collaboration with Warna Sriwijaya Foundation between June and October 2025. Data were collected through a structured and validated questionnaire covering …

Ultra-Processed Food Consumption, Physical Activity, And Overweight Among Adolescents: A Path Analysis In Indonesia, Oktia Woro Kasmini Handayani, Syifa Qolbiyah Nasir, Rinta Amalia, Rafidha Nur Alifah, Ida Leida Maria, Wahiduddin Wahiduddin, Andi Selvi Yusnitasari

Media Kesehatan Masyarakat Indonesia

The prevalence of overweight in adolescents aged 13–15 has increased from 2018 (11.2%) to 2023 (12.1%), as well as the impacts caused in the short and long term related to degenerative diseases. This study aimed to analyze the influence of Ultra-Processed Food (UPF) consumption habits and physical activity on overweight incidence among adolescents. A quantitative approach was employed, involving 280 junior high school students in Tangerang Regency, Banten Province, Indonesia, selected through quota sampling based on inclusion and exclusion criteria. The independent variables were UPF consumption habits and physical activity, while the dependent variable was the incidence of over-weight. Age, …

Modeling Perceived Organizational Support, Orientation Toward Organization, And Well-Being In Enhancing Intention To Stay, Muhammad Risya Rizki, Achmad Djunawan, Stefanus Supriyanto, Ernawaty Ernawaty, Tatin Wahyanto, Heru Wijono, Agus Aan Adriansyah

Media Kesehatan Masyarakat Indonesia

High employee turnover is often considered an indication of un-derlying organizational issues. The employee withdrawal decision process emphasizes that job satisfaction has a direct influence on an employee's intention to stay or quit. This research aims to model how Perceived Organizational Support (POS), orientation toward the organization and work, and employee well-being enhance in-tention to stay. This research is an analytical observational study with a cross-sectional research design. This study was conducted at Private Hospital X in Surabaya from November to December 2024. The population of this study consists of all employees working at Hospital X in Surabaya. The study …

Cost-Effectiveness Analysis For Neonatal Hypothyroidism Screening: A Systematic Review, Izza Fitrotun Nisa, Nurajizah Kalla, Welsa Indrias, Dilma Suzete Bento Alves Pereira, Firdaus Hafidz, Mufdlilah Mufdlilah

Media Kesehatan Masyarakat Indonesia

Neonatal hypothyroidism screening plays a crucial role in preventing irreversible neurological disorders causing developmental delays. Therefore, the policy decisions are needed based on context-appropriate cost-effectiveness analysis studies. Trend of evidence on cost-effectiveness is still dominated by studies from high-income countries. This evidence cannot be directly generalized to developing countries context such as Indonesia, which differ in health systems, financing, and access to services. In response to this issue, this study aims to analyze cost-effectiveness of using a systematic review approach of five studies following PRISMA-SR guidelines. This study systematically mapping threshold simulation analysis by evaluating the results of each study …

A Pathogenic Tau Mutation Drives Autophagy-Lysosome Dysfunction That Limits Tau Degradation In A Model Of Frontotemporal Dementia, Farzaneh S Mirfakhar, Jacob A Marsh, Chihiro Sato, Kylie J Schache, Miguel A Minaya, Roland E Dolle, Stephen C Pak, Gary A Silverman, David H Perlmutter, Shannon L Macauley, Celeste M Karch

2020-Current year OA Pubs

Tau accumulates in a group of neurodegenerative diseases known as tauopathies. A prevailing hypothesis has been that Tau degradation is impaired due to an age-related imbalance in the autophagy-lysosome pathway, but whether these defects are a cause or consequence of Tau accumulation remains unclear. Here we show that a disease-causing mutation in the MAPT gene, which encodes Tau, p.R406W, is sufficient to disrupt multiple steps of the autophagy-lysosome pathway in human neurons. Using Airyscan super-resolution imaging, we find that mutant Tau neurons accumulate Tau and phosphorylated Tau in dysfunctional lysosomes, exhibit reduced lysosome motility, impaired fusion of autophagosomes and lysosomes, …

Ketone Body Supplementation Exerts Renoprotective Effects Against Adenine-Induced Kidney Injury Via Oxct1-Mediated Ketolysis In Mice, Shoji Omachi, Sho Sugahara, Junya Horiguchi, Mako Yasuda-Yamahara, Shogo Kuwagata, Kosuke Yamahara, Yuki Tanaka-Sasaki, Shogo Ida, Tetsuro Kusaba, Benjamin D Humphreys, Kenji Kufukihara, Jin Nakahara, Masami Chin-Kanasaki, Shinji Kume

2020-Current year OA Pubs

Ketone bodies have traditionally been recognized as glucose-sparing energy sources, with hepatic ketogenesis and peripheral ketolysis serving pivotal functions in maintaining energy homeostasis during fasting. Although they are commonly seen as harmful due to their link with ketoacidosis, recent studies emphasize their roles in organ protection. This has sparked interest in their possible use as a treatment for chronic kidney disease (CKD). In this study, we examined both exogenous and endogenous ketone body supplementation in adenine-induced kidney injury in mice. Supplementation with the ketone body precursor 1,3-butanediol significantly improved adenine-induced renal fibrosis, inflammation, and apoptotic cell death. However, genetically deleting …

Post-Hemorrhagic Hydrocephalus Of Prematurity Is Associated With Disruption Of Tight Junctions And Increased Macrophage Activity In The Choroid Plexus, Maria Garcia-Bonilla, Rajiv Swarup, Owen W Limbrick, Habeebah Z Vohra, Ayodamola Otun, Konrad Mckalip, William Bernhardt, Kirill Shumilov, Marie Michenkova, Jayne Crouthamel, Mackenzie Newman, Krikor Dikranian, James P Mcallister Ii, David D Limbrick

2020-Current year OA Pubs

BACKGROUND: Previous studies on intraventricular hemorrhage (IVH), a common and severe complication of preterm birth, and subsequent post-hemorrhagic hydrocephalus (PHH), have predominantly concentrated on the secretory function of the choroid plexus (ChP), with considerably less emphasis on its barrier function. We hypothesized that PHH is associated with immune-related alterations in the junction biology of ChP. METHODS: We examined differences in tight junctions and macrophages using a neonatal mouse model of PHH (n = 40) and in vitro ChP explants (n = 22), as well as human post-mortem samples (n = 6). To test our hypothesis, we employed histology, immunofluorescence, magnetic …