Digital Commons Network^™

Abca4 Versus Prph2-Associated Retinopathy: Clinical And Electrophysiological Findings, Rachael C. Heath Jeffery, A. Thompson, Johnny Lo, Andrea L. Vincent, Minal Patil, Lorenzo Bianco, Maurizio Battaglia Parodi, Lucia Ziccardi, Carmen Dell’Aquila, Lucilla Barbano, Wei Chao Tang, Choi Mun Chan, Camiel J.F. Boon, Jonathan Hensman, Ta Ching Chen, Chien Yu Lin, Pei Lung Chen, Ajoy Vincent, Anupreet Tumber, Elise Heon, John R. Grigg, Robyn V. Jamieson, Elisa E. Cornish, Benjamin N. Nash, Jeremy Chou, Tina M. Lamey

Research outputs 2022 to 2026

Purpose. The purpose of this study was to characterize the clinical features, electrophysiology, and variant spectrum in ABCA4- and PRPH2-retinopathies and to identify novel electrodiagnostic biomarkers to differentiate between these two genotypes. Methods. We conducted an international multicenter case-control study of patients with a clinical and genetic diagnosis of ABCA4- or PRPH2-retinopathy. Age at symptom onset, best-corrected visual acuity (BCVA), electroretinography (ERG) components, and fundus autofluorescence (FAF) imaging were compared. Subgroup exploratory analysis was performed on those patients with a phenotype similar to central areolar choroidal dystrophy (“CACD-like”), those with flecks distributed throughout the posterior pole (“fleck-like”) and a healthy …

Trends In Meningioma-Related Mortality Among U.S. Adults: A Cdc Wonder Analysis From 2000 To 2023, Tirath Patel, Rai Muhammad Umar Khan, Fatima Hussain, Meer Murtaza, Muhammad Shayan Tariq, Abuzar Khan, Sara Aleem, Maryam Athar, Sharoz Shahid, Nikhilesh Anand

School of Medicine Publications

Background: Meningiomas are the most common primary intracranial tumors in the United States, comprising nearly 41% of central nervous system tumors. While the majority are benign, atypical (World Health Organization Grade II) and malignant (Grade III) subtypes are clinically significant due to their aggressive biology, higher recurrence, and increased mortality risk. Despite their burden, national mortality trends and demographic disparities in meningioma-related deaths remain underexplored.

Methods: We conducted a population-based analysis of meningioma-related mortality among U.S. adults aged ≥65 years from 1999 to 2023 using the centers for disease control and prevention (CDC) wide-ranging online data for epidemiologic research (WONDER) …

When Birth Control Turns Biliary: A Rare Case Of Profound Hyperbilirubinemia From Oral Contraceptives, Taiwo Ajani, Aura Calderon, Jose J. Loayza Pintado, Nayiri Derian, Catherine Matos, Ivan Mogollon, Andres Suarez Parraga

School of Medicine Publications

Oral contraceptives (OCs) are extensively utilized and generally considered safe (reference); nonetheless, infrequent hepatobiliary complications such as cholestasis and hyperbilirubinemia have been documented, particularly among individuals with a genetic predisposition. We present a case involving a 19-year-old female who exhibited significant conjugated hyperbilirubinemia shortly after the commencement of OC therapy. Comprehensive investigations ruled out alternative causes, and the findings from liver biopsy, in conjunction with the clinical context, indicated an estrogen-induced cholestatic injury, likely revealing an underlying Dubin–Johnson syndrome. This case underscores the critical necessity of acknowledging hepatic adverse effects associated with estrogen as well as the influence of genetic …

The Anchored: Issue 3, Spring 2026, Writer's Club Of The Hope-Western Prison Education Program

The Anchored

The Anchored is a quarterly publication of the Writer’s Club of the Hope-Western Prison Education Program.

The Territorial Continuum: American Samoa, Criminal Adjudication, And Territorial Administration, Emmanuel Hiram Arnaud

Faculty Scholarship

The standard account of American territorial expansion posits that territorial acquisition moved along a spectrum of sovereignty. The federal government acquired new inhabited land through conquest or purchase, and the Constitution tasked Congress with organizing and administering the new territories until they were ready to become states. That pattern came to an abrupt halt in 1898 when, at the conclusion of the Spanish-American War, the Supreme Court, fearing the extension of citizenship to, and the permanent integration of, non-White populations into the American polity, suddenly pronounced that the Constitution authorized the holding of colonies. The Court thus sentenced new territories, …

Uncovering Ethical Values In Information Systems Development Methodologies, Zahidah Zulkifli, Noor Hayani Abd Rahim, Tahmid Alam, Fakhrul Hazman Yusoff, Mohammad Masudur Rahman

Malaysian Journal of Computing (MJoC)

Information system development involves a lot of tools, infrastructures, and humans. The many phases in system development need humans to interact and work with each other to obtain the goal: to complete information system development. These interactions of humans require the right ethics to ensure that the information system development can be successful. For example, ethical leadership is a vital component in determining the success of any project related to information system development in organizations. The aim of this study is to identify the ethical values which are important in information system development methodology phases. This systematic literature review (SLR) …

Textual Adversarial Example Generation Using Bigram Unigram-Semantic Preservation Optimization Algorithm, Noor Adam Noor Azmi, Haslizatul Fairuz Mohamed Hanum

Malaysian Journal of Computing (MJoC)

The vulnerability of Natural Language Processing (NLP) models to adversarial attacks remains a critical challenge in the field of cybersecurity and AI robustness. While deep learning models have achieved high performance in sentiment analysis, they are susceptible to subtle input perturbations that induce misclassification. This study presents the design and practical implementation of a web-based system (Proof of Concept) that automates the generation of textual adversarial examples using the Bigram Unigram-Semantic Preservation Optimization (BU-SPOF) algorithm. Rather than proposing a novel attack algorithm, our primary contribution is the architectural integration of a dual-source candidate generation strategy (WordNet and OpenHowNet) and a …

Structuring The Notional Imprisonment Period When The Accused Is Unfit To Plead – Abdul Ghufran Bin Abdul Wahid V Public Prosecutor, Abhishek Behera, Aaron Yoong

Research Collection Yong Pung How School Of Law

This case comment examines how Abdul Ghufran bin Abdul Wahid v Public Prosecutor [2025] 3 SLR 1572 brings clarity to Singapore’s “fitness to plead” regime by structuring the nominal imprisonment period (“NIP”) as a principled, non-punitive ceiling on confinement for unfit accused persons. It explains the General Division of the High Court’s four-step framework, the elevation of prevention over rehabilitation at the NIP stage, and the constrained role of mental disorders in adjusting the provisional term. It further highlights the decisive influence of psychiatric evidence and explores how the framework mediates between consistency, individualised justice, and public protection.

Powell’S Overland Trip To The Grand Canyon, Daniel Styer

Faculty & Staff Scholarship

No abstract provided.

A Model For Professional Organization Membership Support: Trust, Commitment, Membership Value, And Relationship Quality Commitment, Shawn F. Clouse, Nader H. Shooshtari, Simona Stan, Liz Kohl

AMTP Proceedings 2026

Members of professional associations join these organizations for reasons that include benefits and services to members, advocacy and lobbying on behalf of members and their interests, networking opportunities, and a sense of community and identification with fellow association members. Members are likely to commit to the association and remain as members to the extent they are satisfied with what the association provides and if they perceive the benefits to exceed the costs (not just monetary) of membership. This survey of members of a professional association investigates the relationship between trust, relationship quality commitment, membership dues value and commitment (normative, affective, …

Exploring The Effect Of Counterstereotype And Perspective Taking In Reducing Bias And Promoting Empathy In Police, Sydney C. Timmer-Murillo, Keara Kangas, Nakia Gordon

Psychology Faculty Research and Publications

Racism in policing continues to be a serious issue in the United States (U.S.). While most efforts to reduce racism, focus on changing implicit (i.e., nonconscious) racial biases, other factors may also influence behavior. Intergroup emotion theory posits that emotions, especially empathy, may play a powerful role in changing behavior. In this study, using community-based participatory research design we created and tested a virtual reality (VR) experience designed to reduce implicit racial bias through perspective taking and counter-stereotypical information. Fifty-six police officers from a large city took part in the study. They completed questionnaires and an implicit association task (IAT) …

Chimes: April 1, 2026, Calvin University

Chimes

Kelvin president to be replaced with AI, sources say by I Am Choking

Rodrick Heffley selected as Kelvin's next provost by Alex De Old

Kelvin announces transition to subscription model by June B. Under

Less-Than-Creative Dining explains the disappearance of meat week by Zachiachus Kolonel

Kelvin adds artificial intelligence department, cuts engineering and business programs by Henry B. Len

Student workers at Peter's to be replaced with campus squirrels by Inca Left-Nonbinary

Client And Self-Advocacy In Coordinated Entry: A Qualitative Case Study Of King County, Washington’S Coordinated Entry For All, Ugochinyere Onyeukwu

Theses and Dissertations from DePaul University

Despite policy attempts to address homelessness, it remains a societal concern. One such policy effort was the U.S. Department of Housing and Urban Development’s mandated implementation of Coordinated Entry (CE) systems, a streamlined, equitable approach to match individuals to the appropriate housing intervention based on need and housing vulnerability. However, research indicates that CE may not produce the desired outcomes. There is limited research identifying factors that may interfere with effective need-based housing allocation. Thus, this qualitative study aimed to gain insight into advocacy in CE as a potential factor influencing implementation. This study used Qualitative Content Analysis to explore …

Multiscale Effects Of Landscape Structure, Biodiversity, And Chronic Physiological Stress In Atlantic Forest Small Mammals, Lizette Arroyo

Theses and Dissertations from DePaul University

Habitat loss and fragmentation are major drivers of biodiversity decline and can alter the physiological condition of wildlife through changes in habitat quality, resource availability, and community composition. The Atlantic Forest of South America is one of the world’s most threatened biodiversity hotspots. This study examined relationships among biodiversity, landscape structure, and chronic stress in nonvolant small mammals within the Reserva Natural Tapytá in eastern Paraguay using hair glucocorticoid concentrations as indicators of long-term physiological stress. Small mammals were sampled from forest fragments representing multiple patch sizes between 2023 and 2025. Hair cortisol and corticosterone concentrations were quantified using enzyme …

Experiential Learning In Marketing Education: Student Reflections In A Client Based Project, Samit Chakravorti

AMTP Proceedings 2026

This paper explores student experience with a client based project in an upper division marketing class and its impact on development of work readiness skills, learning and satisfaction with the course. The client was a local small business food cooperative. Student reflection papers submitted at the end of the project were content analyzed based on preset categories to understand the impact of the project on the outcome variables. Analysis shows that for most students the project was interesting, relevant but challenging, increased their satisfaction and enjoyment of the course, and positively impacted learning of profession specific and foundational work ready …

Methodological Progress Note: Logic Models, Molly J Horstman, Kyler M Godwin

Faculty and Staff Publications

Logic models are an accessible tool to organize the planning, management, and evaluation of programs across healthcare disciplines. This methodological progress note describes the five standard components of a logic model (Inputs, Activities, Outputs, Outcomes, and Impact) and provides guidance for developing a logic model. Logic models offer a visual representation of the work and theory of a program and should be created with input from all interested parties. Logic models are living tools that need to be revised as programs evolve and new information becomes available.

Tfeb Degradation Is Regulated By An Ikk/Β-Trcp2 Phosphorylation-Ubiquitination Cascade, Yan Xiong, Jaiprakash Sharma, Meggie N Young, Wen Xiong, Ali Jazayeri, Karl F Poncha, Ma Xenia G Ilagan, Qing Wang, Bei Gao, Hui Zheng, Nicolas L Young, Marco Sardiello

Center on Aging Staff Publications

Transcription factor EB (TFEB) is a master regulator of lysosomal biogenesis and cellular clearance pathways. TFEB activity is tightly controlled by multiple post-translational mechanisms, but the exact molecular mechanism controlling its stability has remained elusive. Here, we identify the IκB kinase (IKK) complex as a key regulator of TFEB protein stability through a phosphorylation-ubiquitination cascade. A high-content kinase inhibitor screen reveals that IKK inhibition increases TFEB protein levels, and genetic ablation of IKK components increases TFEB stability, upregulates lysosomal genes, and enhances lysosomal biogenesis and degradative capacity. Mechanistically, we show that IKK phosphorylates TFEB on a cluster of serine residues …

Birthdate Phaseout, Katharine B. Silbaugh

Faculty Scholarship

This Article explores the Nicotine Free Generation ("NFG") policy, an emerging endgame strategy for tobacco products that employs a completely novel legal design. Tobacco remains the leading cause of preventable death, killing almost half of its users and imposing $600 billion in social costs each year. We see two basic choices for regulating sales: prohibition or a legal age-gate, such as twenty-one, for retail sales. NFG charts a third way. Recognizing the dire harm of tobacco and the serious consequences of abrupt prohibition, NFG lays the groundwork for a gradual transition to a sales sunset. In place of the twenty-one …

The Human Right To A Healthy Environment: Corporate Responsibility In Critical Mineral Extraction, Erika George

Faculty Scholarship

This paper argues that the emerging human right to a clean, healthy, and sustainable environment should guide the governance of critical minerals by incorporating the corporate responsibility to respect human rights throughout supply chains to ensure a racially just energy transition. It frames the climate crisis within the history and political economy of racial capitalism, contending that without rights-based guardrails, mineral supply chains risk reproducing the extractive harms and racialized disparities of the fossil fuel era, including labor abuses, displacement, water depletion, and violence disproportionately borne by racialized and Indigenous communities. Methodologically, the paper combines doctrinal analysis of international norms …

Association Of Higher Body Mass Index With Imaging Escalation And Operative Complexity In Pediatric Appendicitis, Ryan T. Davis, Sahithi Pemmasani, Margaret Menoch

Conference Presentation Abstracts

Background: Obesity may complicate clinical assessment and ultrasound (US) evaluation in children with appendicitis, potentially increasing reliance on computed tomography (CT). At the same time, national pediatric quality-improvement initiatives and ALARA-driven imaging pathways emphasize reducing CT use and promoting US-first approaches. Data examining how body mass index (BMI) influences diagnostic pathways within these modern low-radiation protocols are limited.

Objective: To determine whether higher BMI is associated with greater CT utilization, escalation from US to CT, nondiagnostic US examinations, emergency department (ED) length of stay (ED-LOS), and operative duration in children with appendicitis.

Design/Methods: This retrospective cohort study included patients < 18 years with surgically confirmed appendicitis presenting to a tertiary pediatric ED from January 1, 2010, to December 31, 2023. Consistent with prior dataset methodology, encounters were identified through structured EHR query using ICD-10 and CPT codes and restricted to unique first visits. A total of 2,275 children were included; BMI was available for 2,012 (88%). BMI was analyzed in quartiles. Imaging modality (US-only, CT-only, or CT after US) and operative duration (proxy for case complexity) were evaluated. χ² and Wilcoxon tests and odds ratios (OR) with 95% CI were used. IRB approval was obtained (Corewell Health IRB No. 2024-128).

Results: …

Emote - A Modular Action Figure For Childhood Emotional Growth, Terrence Li

Theses

Emotional regulation and communication are one of the most important skills that we can learn. This skill allows us not only to recognize and effectively communicate our feelings to others but also allows us to recognize them in others. Although learning and recognizing these emotions may be a pursuit in which progress varies from person to person, this skill is especially invaluable to young children. Beginning as early as the age of 3, many children begin to show early awareness of their own emotions, such as reacting to discomfort or comfort, or starting to use words for feelings. This learning …

Targeting Unfairness, Omolara Bewaji Joseney

Vanderbilt Law Review

Companies often engage in racially targeted marketing practices whereby they target and tailor their advertisements to racially segmented consumer populations. As a result, a targeted racial group of consumers may receive advertisements for a product or service that is intentionally customized to appeal to them (a “pull”) or may be specifically untargeted or excluded from receiving advertisements as members of a nontargeted racial group (a “push”). This Article examines the marketing environment created by these pull-push dynamics as a consumer protection concern. Legal scholarship on targeted advertising has focused either on its risks to privacy due to the growing reliance …

Twitter, Tiktok, And Terrorism Torts: Using Product Liability To Hold Social Media Companies Accountable For Their Enablement Of Terrorism, Bailey Wilson

Vanderbilt Law Review

Social media platforms have become powerful tools for terrorist organizations, allowing them to recruit and radicalize actors who incite violence. Yet victims of terrorist attacks have been unsuccessful in holding these platforms legally accountable. The Antiterrorism Act imposes a demanding proximate-cause standard, and Section 230 of the Communications Decency Act broadly shields platforms from liability as publishers of third-party content. Together, these doctrines create a nearly impenetrable barrier for plaintiffs seeking redress from companies that profit while their algorithms amplify terrorist propaganda and promote violence. This Note argues that product liability offers a path forward. Courts have increasingly recognized digital …

Giving Meaningful Effect To Victims’ Rights: The Canadian Victims Bill Of Rights As Quasi-Constitutional Legislation, Benjamin Perrin

All Faculty Publications

This research paper is the first detailed examination of the quasi-constitutional status of the Canadian Victims Bill of Rights ("CVBR") and the implications for its interpretation and application. It aims to provide a doctrinal account of this extraordinary legal recognition and to serve as a resource for scholars, judges, lawyers, and other justice system participants to ensure that the CVBR is interpreted and applied consistently with its aim of serving as a catalyst for transformative change to how the criminal justice system has historically treated victims.

Towards Reliable And Trustworthy Deep Learning Through Explainability And Interpretability, Dipkamal Bhusal

Theses

Deep neural networks achieve state-of-the-art performance across many domains, yet their deployment in high-stakes settings is constrained by two challenges: opaque decision-making and vulnerability to adversarial manipulation. This thesis investigates explainability and interpretability as principled mechanisms for improving the reliability and trustworthiness of deep learning models. First, we develop new post-hoc explanation methods that improve feature attribution and concept-based explanations. These methods provide faithful decision cues by modeling meaningful feature interactions and extracting faithful coherent concepts, enabling more reliable understanding of why a model predicts a given label. Second, we show that explanation quality is not solely a property of …

How Policing Data Visualizations Affect Comprehension, Decision Confidence, And Perceptions Of Racial Disparities, Abeer Mustafa

Theses

Police departments use public dashboards to share use-of-force data for policymaking and public awareness, but it remains unclear how visualization formats affect how people interpret this information. This between-subjects study with 64 participants compares absolute use-of-force incident counts (Totals) and population-adjusted rates (Rates) across four United States cities. The research included a quantitative analysis of graph comprehension, policy prioritization, confidence ratings, and attitude change, as well as a qualitative examination of open-ended responses. Results showed a strong framing effect: those who viewed absolute numbers prioritized Aurora, Colorado (highest incidents) for policy intervention, often disregarding population baselines, while those viewing per-capita …

Leveraging Machine Learning For Traffic Congestion Management In Smart Cities, Omar Alhasai

Theses

Traffic congestion continues to be a major urban issue, leading to traffic delays, higher fuel costs, and air pollution problems. Traffic management systems currently function in reactive mode because their algorithms only operate following congestion development rather than preventing it. Smart cities need predictive systems based on data analytics and machine learning to actively control urban traffic movements because traffic continues to rise as a result of urbanization and population growth. The proposed research designs a machine learning–driven traffic congestion prediction system that uses genuine data obtained from Aarhus, Denmark, and METR-LA, Los Angeles. The study will analyze fundamental traffic …

Wegmans School Of Health And Nutrition’S Culinary Kitchen Cart Manual Development, Neena Bhala

Theses

To facilitate the initiation of culinary medicine at RIT, a manual to guide the use of a mobile kitchen cart was developed and evaluated. This manual was developed to support faculty, staff, and students’ use of a Mobile Kitchen Cart to be able to support culinary medicine and nutrition education activities. The Manual was directed to RIT faculty, staff, and students who have experience with the cart or intend to have future use with the cart. A qualitative evaluation study was conducted with ten participants including RIT faculty (n=2), students (n=4), and staff (n=4). Feedback on the manual was obtained …

A Comparative Study Of Inference-Time Scaling Strategies For Large Language Models, Oluwamayowa Owolabi

Theses

Large language models (LLMs) have demonstrated strong performance on a range of reasoning tasks, however, their reliability often depends not only on model size or training data, but also on inference-time strategies. However, existing inference-time methods are typically evaluated in isolation and under differing experimental assumptions, making it difficult to draw systematic conclusions about their relative effectiveness. This thesis proposes a controlled empirical study of inference-time scaling strategies for large language models under fixed inference-time compute budgets. The findings reveal that no single strategy dominates uniformly. PRM guided selection with the IBM Granite verifier achieves the highest absolute accuracy across …

Software Vulnerability Recidivism In Open-Source Projects, Brandon Keller

Theses

Software vulnerabilities present a major threat to businesses and individuals alike and it is therefore critical that a culture exists among software engineers to encourage the discovery and patching of security flaws. Vulnerability counts are a common way of evaluating a project’s security. However, this metric can run counter to building a developer culture of fault recognition if more vulnerabilities is always seen as a bad thing. While these counts can present a rough idea of a project’s history with security, they provide no insight into how the development team improves and learns as a result of a vulnerability. A …