Digital Commons Network^™

Bibliometric Analysis Of Spinopelvic Alignment In Total Hip Arthroplasty, Samantha Harrer, Justin A. Magnuson, Gregory R. Toci, Andrew M. Star, Arjun Saxena

Rothman Institute Papers

INTRODUCTION: Postoperative dislocation of unclear etiology remains a concern after total hip arthroplasty (THA). Interest is growing in the importance of spinopelvic alignment on stability in THA. The purpose of this study was to analyze publication trends, areas of interest, and future research direction of spinopelvic alignment in THA.

METHODS: Articles on the topic of spinopelvic alignment in THA published between 1990 and 2022 were obtained through Web of Science Core Collection of Clarivate Analytics (WSCCA). Results were screened by title, abstract, and full text. The inclusion criterion was English-language peer-reviewed journal publications on the clinical topic of spinopelvic alignment …

2023-06-16 Faculty Regent Report, Morehead State University. Faculty Senate., Annie Adams

Faculty Senate Records

A report submitted by the Faculty Board of Regent member to the Faculty Senate on June 16, 2023.

Lbsci 717: Digital Humanities, S E. Hackney

Open Educational Resources

This is a syllabus for a graduate-level introductory course on the Digital Humanities, primarily aimed at LIS students.

Latinx Students Higher Educational Trajectory Post Covid, Jonathan Felix-Martinez

University Honors Theses

COVID-19 caused many universities to go fully remote during the pandemic. Many Latinx students did not know how to navigate online learning. This paper examines the experiences of Latinx students in their university experiences while online to determine if their higher educational trajectory changed as a result of the effects of the COVID-19 pandemic. This qualitative project gathered data from 9 Latinx students using in-depth, in-person interviews. Recommendations are presented to help the university create resources that will help improve Latinx students' experiences within the context of online learning and the effects of the recent pandemic.

The Evolution Of Leadership During The Covid-19 Pandemic: An Analysis Of The Research, Luca Patrick Thierry Gregston

University Honors Theses

This paper's research question, "How has the COVID-19 pandemic changed the concept and practice of leadership? In the end much of the empirical evidence for what COVID-19 did or didn't change in leadership practices is still relatively ambiguous. So it is too early to say that "business as usual" is gone for good. And COVID furthered and deepened long term trends, accelerating the great resignation and a dramatic revaluation of intangible assets like reputation, intellectual property and human capital. In response, there is a clear need for a new leadership mindset for the 21st century after the COVID pandemic.

Fanning The Embers Of Discrimination At Work: Does Reward Structure Fuel Incivility?, Sam Allen

University Honors Theses

In recent years, there has been an uptick in public awareness of systemic and structural inequities within the workplace. Organizational reward structures (i.e., performance-based and seniority-based) act as incentives for employees' contributions toward organizational goals, but could also motivate employees' drive for gaining or maintaining social status by undermining other employees, particularly targeting people with minority status. The proposed research will study the relationship between reward structures and the perpetration of incivility by accounting for perpetrators' social dominance orientation (SDO), their motivations to protect the status quo (MPSQ), and the presence of minority race targets. We draw from SDO, status …

Network Tango: Examining State Dispositions Toward Attribution In International Cyber Conflict, Robert Riley Turner

University Honors Theses

Cyberspace is an environment of international conflict often sought out due to its ability to create significant effects at little cost, and obfuscating the ready attribution of hostility. One avenue toward streamlining the attribution of hostile actions in cyberspace is the introduction of a due diligence of data transparency amongst states. This level of data transparency must somehow be incentivized. The following study surveys the geopolitical dispositions of three major powers that utilize cyberspace as a venue of conflict: The United States, China, and Russia; in order to determine how each nation might interact with an international due diligence of …

Alternatives To Antibiotics In Veterinary Medicine: Considerations For The Management Of Johne's Disease, Laura M. O'Connell, Aidan Coffey, Jim O'Mahony

Dept. of Biological Sciences Preprints

Antibiotic resistance has become a major health concern globally, with current predictions expecting deaths related to resistant infections to surpass those of cancer by 2050. Major efforts are being undertaken to develop derivative and novel alternatives to current antibiotic therapies in human medicine. What appears to be lacking however, are similar efforts into researching the application of those alternatives, such as (bacterio)phage therapy, in veterinary contexts. Agriculture is still undoubtedly the most prominent consumer of antibiotics, with up to 70 % of annual antibiotic usage attributed to this sector, despite policies to reduce their use in food animals. This not …

Novel Potential Targets For Function-Promoting Therapies: Orphan Nuclear Receptors, Anti-Inflammatory Drugs, Troponin Activators, Mas Receptor Agonists, And Urolithin A, Waly Dioh, Vihang Narkar, Anurag Singh, Fady Malik, Luigi Ferrucci, Cendrine Tourette, Jean Mariani, Rob Van Maanen, Roger A Fielding

Faculty, Staff and Student Publications

In recent years, several new classes of therapies have been investigated with their potential for restoring or improving physical functioning in older adults. These have included Mas receptor agonists, regulators of mitophagy, skeletal muscle troponin activators, anti-inflammatory compounds, and targets of orphan nuclear receptors. The present article summarizes recent developments of the function-promoting effects of these exciting new compounds and shares relevant preclinical and clinical data related to their safety and efficacy. The development of novel compounds in this area is expanding and likely will need the advent of a new treatment paradigm for age-associated mobility loss and disability.

Gata6-As1 Regulates Intestinal Epithelial Mitochondrial Functions, And Its Reduced Expression Is Linked To Intestinal Inflammation And Less Favourable Disease Course In Ulcerative Colitis, Katya E Sosnovski, Tzipi Braun, Amnon Amir, Danielle Moshel, Marina Benshoshan, Kelli L Vandussen, Nina Levhar, Haya Abbas-Egbariya, Katia Beider, Rakefet Ben-Yishay, Syed Asad Ali, Sean R Moore, Subra Kugathasan, Ifat Abramovich, Efrat Glick Saar, Batya Weiss, Iris Barshack, Eyal Gottlieb, Tamar Geiger, Shomron Ben-Horin, Igor Ulitsky, Jeffrey S Hyams, Lee A Denson, Yael Haberman

Faculty, Staff and Student Publications

BACKGROUND AND AIMS: Widespread dysregulation of long non-coding RNAs [lncRNAs] including a reduction in GATA6-AS1 was noted in inflammatory bowel disease [IBD]. We previously reported a prominent inhibition of epithelial mitochondrial functions in ulcerative colitis [UC]. However, the connection between reduction of GATA6-AS1 expression and attenuated epithelial mitochondrial functions was not defined.

METHODS: Mucosal transcriptomics was used to conform GATA6-AS1 reduction in several treatment-naïve independent human cohorts [n=673]. RNA pull-down followed by mass spectrometry was used to determine the GATA6-AS1 interactome. Metabolomics and mitochondrial respiration following GATA6-AS1 silencing in Caco-2 cells were used to elaborate on GATA6-AS1 functions.

RESULTS: GATA6-AS1 …

Ulama's Resistance To The Closing Of Worship Places During The Covid-19 Pandemic In Indonesia, Luthfi Hadi Aminuddin, Isnatin Ulfah, Siti Rohmaturrosyidah Ratnawati, Chafid Wahyudi

The Qualitative Report

PPKM Darurat (the implementation of community activity restrictions) is one of the policies implemented by the Indonesian government to control the spread of COVID-19. PPKM Darurat received opposition from ulama (Islamic religious leaders) because all places of worship had to be closed. Our qualitative study explores the forms, factors, and impacts of ulama’s resistance to the closing of worship places during the COVID-19 pandemic. This research data were collected through interviews with participating ulama. This study indicates that ulama’s resistance to the closure of places of worship during the PPKM Darurat period manifested in discourse and action. In …

Prognostic Role Of Cd68+ And Cd163+ Tumour-Associated Macrophages And Pd-L1 Expression In Oral Squamous Cell Carcinoma: A Meta-Analysis, Mohammed Haseeb Chohan, Matthew Perry, Paul Laurance-Young, Vehid M. Salih, Andrew D. Foey

Peninsula Dental School

Background: Oral squamous cell carcinoma (OSCC) is a common malignant cancer in humans. An abundance of tumour associated macrophages (TAMs) create an immunosuppressive tumour microenvironment (TME). TAM markers (CD163 and CD68) are seen to serve as prognostic factors in OSCC. PD-L1 has seen to widely modulate the TME but its prognostic significance remains controversial. The aim of this meta-analysis is to evaluate the prognostic role of CD163+, CD68+ TAMs and PD-L1 in OSCC patients. Methods: Searches in PubMed, Scopus and Web of Science were performed; 12 studies were included in this meta-analysis. Quality assessment of included studies was performed according …

Transmembrane Stem Factor Nanodiscs Enhanced Revascularization In A Hind Limb Ischemia Model In Diabetic, Hyperlipidemic Rabbits, Eri Takematsu, Miles Massidda, Gretchen Howe, Julia Goldman, Patricia Felli, Lei Mei, Gregory Callahan, Andrew Sligar, Richard Smalling, Aaron Baker

Faculty, Staff and Student Publications

Therapies to revascularize ischemic tissue have long been a goal for the treatment of vascular disease and other disorders. Therapies using stem cell factor (SCF), also known as a c-Kit ligand, had great promise for treating ischemia for myocardial infarct and stroke, however clinical development for SCF was stopped due to toxic side effects including mast cell activation in patients. We recently developed a novel therapy using a transmembrane form of SCF (tmSCF) delivered in lipid nanodiscs. In previous studies, we demonstrated tmSCF nanodiscs were able to induce revascularization of ischemia limbs in mice and did not activate mast cells. …

Electrical & Computer Engineering, Georgia Southern University

Electrical & Computer Engineering: News & Publications (2014-2023)

• ECE Department Is Hiring Visiting Instructor

Hierarchical Wilson–Cowan Models And Connection Matrices, Wilson A. Zuniga-Galindo, Brian A. Zambrano-Luna

School of Mathematical & Statistical Sciences Faculty Publications

This work aims to study the interplay between the Wilson–Cowan model and connection matrices. These matrices describe cortical neural wiring, while Wilson–Cowan equations provide a dynamical description of neural interaction. We formulate Wilson–Cowan equations on locally compact Abelian groups. We show that the Cauchy problem is well posed. We then select a type of group that allows us to incorporate the experimental information provided by the connection matrices. We argue that the classical Wilson–Cowan model is incompatible with the small-world property. A necessary condition to have this property is that the Wilson–Cowan equations be formulated on a compact group. We …

Beyond The Clock: Exploring The Complexities Of Women’S Domestic Roles In India Through The Lenses Of Daughters And Daughters-In-Law, Pushpendra Singh, Falguni Pattanaik, Archana Singh

Articles

This study aims to estimate the distribution of time spent on unpaid activities in India, with a focus on understanding the gendered nature of this work. The study seeks to contribute to the existing literature by providing empirical insights into the time spent on unpaid domestic activities by daughters and daughters-in-law, and by identifying the sociocultural and economic factors that contribute to this work. To achieve this objective, the study employs data from the Time Use Survey (TUS) conducted by the National Sample Survey Office (NSSO) in India from January to December 2019. The study uses a two-phase analysis to …

Impact Of Cultural Behaviour On Indoor Comfort: Examining The Air Quality In Homes And Exploring Observational And Experimental Methods Of Representation Through Filmmaking, B. K. Satish, Allister Gall, Sally Shahzad

School of Art, Design and Architecture

There is a limited understanding of householders' cultural differences and their impact on spatial organisation and energy behaviour in dwellings. Indoor air quality directly impacts the health and well-being of occupants. The airborne COVID-19 epidemic has highlighted shortcomings of controlled ventilation systems in recent reports (PHE, Dec 2020). While efficiency interventions can make homes more affordable to heat, they can exacerbate conditions such as asthma, due to reduced indoor air quality and ventilation. Preliminary research conducted in Plymouth by the applicant indicates that British Asians use their homes differently compared to native British in terms of spatial organisation, cooking habits …

Book Review: Research Handbook On Ocean Governance Law By Simone Borg, Felicity G Attard And Patricia Mallia Vella De Fremeaux, J Lowther

School of Law, Humanities and Social Sciences

Book Review.

Everyone Could Use A Little Entrepreneurial Resilience, Niamh Imbusch

Irish Journal of Academic Practice

This short opinion piece argues that entrepreneurial resilience is not confined to entrepreneurs; rather, it comprises a mix of personal, transversal skills which can be developed, and which may be to benefit of all students, regardless of discipline. It offers an invitation to third level educators to join a resilience pedagogy community of practice to share experiences and best practice.

New Records Of Southern Pine Beetle (Dendroctonus Frontalis Zimmermann; Coleoptera: Curculionidae) In New York, New Hampshire, And Maine, Usa Indicate Northward Range Expansion, Caroline R. Kanaskie, Thomas C. Schmeelk, Jessica A. Cancelliere, Jeff R. Garnas

Faculty Publications

No abstract provided.

Pharmacogenetic Testing For The Pediatric Gastroenterologist: Actionable Drug-Gene Pairs To Know., Tracy L. Sandritter, Rachel Chevalier, Rebecca Abt, Valentina Shakhnovich

Manuscripts, Articles, Book Chapters and Other Papers

Gastroenterologists represent some of the earlier adopters of precision medicine through pharmacogenetic testing by embracing upfront genotyping for thiopurine S-methyltransferase nucleotide diphosphatase (TPMT) before prescribing 6-mercaptopurine or azathioprine for the treatment of inflammatory bowel disease. Over the last two decades, pharmacogenetic testing has become more readily available for other genes relevant to drug dose individualization. Common medications prescribed by gastroenterologists for conditions other than inflammatory bowel disease now have actionable guidelines, which can improve medication efficacy and safety; however, a clear understanding of how to interpret the results remains a challenge for many clinicians, precluding wide implementation of …

Strengthening Tobacco 21 Implementation And Enforcement To Reduce Tobacco-Related Health Disparities: A Stakeholder Engagement Project., Summer Woolsey, Athena K. Ramos, Kaeli Samson, Delwyn Catley, Keyonna M. King, Rob Crane, Hongying Daisy Dai

Manuscripts, Articles, Book Chapters and Other Papers

INTRODUCTION: As a part of a priority-setting stakeholder engagement project to strengthen the impact of the federal Tobacco 21 (T21) law, we conducted a qualitative study to solicit input from a nationwide sample of tobacco control stakeholders regarding the implementation, enforcement, and equity implications of the T21 law.

METHODS: Following the T21 policy evaluation guidance developed by the Centers for Disease Control (CDC), we identified T21 experts in four domains: policy, evaluation, subject matter, and implementation from a national search of stakeholders (invitations, n=1279) to account for geographical variation. This study presents results from five focus groups conducted in December …

Sustainability Of Open-Access Author Fund: A Case Study Of Faculty Usage Patterns And Apc Cost, Jayati Chaudhuri, Adele Dobry

Library Philosophy and Practice (e-journal)

The California State University, Los Angeles Library established a pilot program on Open-Access (OA) Author Fund in 2018. This article presents information about the management of the University Library's Open-Access Author Fund. Particularly, this article focuses on faculty usage of the OA Author Fund by colleges, disciplines, and publishers. Additionally, the authors examined the article processing charges (APCs) and self-archiving policies of the top open-access journals where Cal State LA faculty publish. This analysis will assist the University Library’s Open-Access Group to understand if the University Library needs to provide additional funding and explore new ways to sustain the funding. …

Medicare Modernization—The Urgent Need For Fiscal Solvency, Brian J. Miller, Lisa M. Grabert, Eric D. Hargan

College of Nursing Faculty Research and Publications

Launched in 1965 based on the design prevalent in employer-sponsored insurance markets, Medicare began as a fee-for-service (FFS) benefit for the “very elderly,” with eligibility at age 65 years when the average life expectancy in the US was approximately 70 years. Fast forward to 2023, more than 60 million Americans depend on Medicare for financing their health benefits. Today, the program faces questions of fiscal sustainability, with hospital insurance (Part A) trust fund insolvency projected for 2028. Leaders across administrations, including former US Department of Health and Human Services Secretaries Burwell and Leavitt and former Center for Medicare & Medicaid …

Predicting Chemotherapy Benefit Across Different Races In Early-Stage Breast Cancer Patients Using The Oncotype Dx Score, Vikram R Shaw, Christopher I Amos, Chao Cheng

Faculty, Staff and Students Publications

Background: Oncotype DX assay, a multigene molecular test, has been widely used to stratify relapse risk and guide chemotherapy treatment in breast cancer. However, the optimal threshold of the Oncotype DX score in predicting chemotherapy benefit and its racial variation has not been investigated.

Methods: In this study, we apply a random forest survival model to the SEER-Oncotype cohort data (Surveillance, Epidemiology, and End Results with Oncotype DX test information for breast cancer patients) and determine chemotherapy benefit thresholds in early-stage, estrogen-receptor-positive (ER+), and HER2-negative (HER2-) patients of different races.

Results: Our results indicate that early-stage ER+, HER2-, and LN-/LN+ …

Coronavirus Disease 2019 Convalescent Plasma Outpatient Therapy To Prevent Outpatient Hospitalization: A Meta-Analysis Of Individual Participant Data From 5 Randomized Trials, Adam C Levine, Yuriko Fukuta, Moises A Huaman, Jiangda Ou, Barry R Meisenberg, Bela Patel, James H Paxton, Daniel F Hanley, Bart J A Rijnders, Arvind Gharbharan, Casper Rokx, Jaap Jan Zwaginga, Andrea Alemany, Oriol Mitjà, Dan Ouchi, Pere Millat-Martinez, Valerie Durkalski-Mauldin, Frederick K Korley, Larry J Dumont, Clifton W Callaway, Romina Libster, Gonzalo Perez Marc, Diego Wappner, Ignacio Esteban, Fernando Polack, David J Sullivan

Faculty, Staff and Students Publications

BACKGROUND: Outpatient monoclonal antibodies are no longer effective and antiviral treatments for coronavirus disease 2019 (COVID-19) disease remain largely unavailable in many countries worldwide. Although treatment with COVID-19 convalescent plasma (CCP) is promising, clinical trials among outpatients have shown mixed results.

METHODS: We conducted an individual participant data meta-analysis from outpatient trials to assess the overall risk reduction for all-cause hospitalizations by day 28 in transfused participants. Relevant trials were identified by searching Medline, Embase, medRxiv, World Health Organization COVID-19 Research Database, Cochrane Library, and Web of Science from January 2020 to September 2022.

RESULTS: Five included studies from 4 …

Targeting Energy Intake And Circadian Biology To Engage Mechanisms Of Aging In Older Adults With Obesity: Calorie Restriction And Time-Restricted Eating, Satchidananda Panda, Geraldine Maier, Dennis T Villareal

Faculty, Staff and Students Publications

With the rise in obesity across age groups, it has been a hindrance to engaging in physical activity and mobility in older adults. Daily calorie restriction (CR) up to 25% has been the cornerstone of obesity management even though the safety in older adults remains incompletely understood. Although some adults can follow CR with clinically significant weight loss and improved health metrics, CR faces 2 obstacles-many fail to adopt CR and even among those who can adopt it short term, long-term compliance can be difficult. Furthermore, there is a continuing debate about the net benefits of CR-induced weight loss in …

Treatment Decisions And The Use Of Mek Inhibitors For Children With Neurofibromatosis Type 1-Related Plexiform Neurofibromas, Amy E Armstrong, Allan J Belzberg, John R Crawford, Angela C Hirbe, Zhihong J Wang

2020-Current year OA Pubs

Neurofibromatosis type 1 (NF1), the most common tumor predisposition syndrome, occurs when NF1 gene variants result in loss of neurofibromin, a negative regulator of RAS activity. Plexiform neurofibromas (PN) are peripheral nerve sheath tumors that develop in patients with NF1 and are associated with substantial morbidity and for which, until recently, the only treatment was surgical resection. However, surgery carries several risks and a proportion of PN are considered inoperable. Understanding the genetic underpinnings of PN led to the investigation of targeted therapies as medical treatment options, and the MEK1/2 inhibitor selumetinib has shown promising efficacy in pediatric patients with …

Personalized [177lu]Lutetium-Psma Therapy For Patients With Pre-Treated Castration-Resistant Prostate Cancer: A Single Institution Experience From A Comprehensive Cancer Centre, Wolfgang Thaiss, Friedemann Zengerling, Julia Friedrich, Veronika Hechler, Michael Grunert, Christian Bolenz, Thomas Wiegel, Ambros J Beer, Vikas Prasad

2020-Current year OA Pubs

Castration resistant prostate cancer (CRPC) is characterized by an aggressive biological behavior with a relatively short survival time, especially in progressive tumors pretreated with new hormonal agents and taxane chemotherapy. [177Lu]-Lutetium-PSMA (Lu-PSMA) treatment has proven efficacy in these patients. However, around 30% of the CRPC patients do not benefit from Lu-PSMA treatment, and little is known about predictive factors for treatment success if Lu-PSMA is offered in an individualized approach based on clinical and laboratory features. In this monocentric retrospective study, 86 CRPC patients receiving Lu-PSMA treatment were evaluated. The focus of the study was to describe clinical factors at …

The Upper And Lower Respiratory Tract Microbiome In Severe Aspiration Pneumonia, Georgios D Kitsios, Janet S Lee, Et Al.

2020-Current year OA Pubs

Uncertainty persists whether anaerobic bacteria represent important pathogens in aspiration pneumonia. In a nested case-control study of mechanically ventilated patients classified as macro-aspiration pneumonia (MAsP, n = 56), non-macro-aspiration pneumonia (NonMAsP, n = 91), and uninfected controls (n = 11), we profiled upper (URT) and lower respiratory tract (LRT) microbiota with bacterial 16S rRNA gene sequencing, measured plasma host-response biomarkers, analyzed bacterial communities by diversity and oxygen requirements, and performed unsupervised clustering with Dirichlet Multinomial Models (DMM). MAsP and NonMAsP patients had indistinguishable microbiota profiles by alpha diversity and oxygen requirements with similar host-response profiles and 60-day survival. Unsupervised DMM …