Digital Commons Network^™

Conditional Deletion Of Lrrc8a In The Brain Reduces Stroke Damage Independently Of Swelling-Activated Glutamate Release, Mustafa Balkaya, Preeti Dohare, Sophie Chen, Alexandra L Schober, Antonio M Fidaleo, Julia W Nalwalk, Rajan Sah, Alexander A Mongin

2020-Current year OA Pubs

The ubiquitous volume-regulated anion channels (VRACs) facilitate cell volume control and contribute to many other physiological processes. Treatment with non-specific VRAC blockers or brain-specific deletion of the essential VRAC subunit LRRC8A is highly protective in rodent models of stroke. Here, we tested the widely accepted idea that the harmful effects of VRACs are mediated by release of the excitatory neurotransmitter glutamate. We produced conditional LRRC8A knockout either exclusively in astrocytes or in the majority of brain cells. Genetically modified mice were subjected to an experimental stroke (middle cerebral artery occlusion). The astrocytic LRRC8A knockout yielded no protection. Conversely, the brain-wide …

Library Workers On The Front Lines Of Conspiracy Theories In The Us: One Nationwide Survey, Stephanie Beene, Katie Greer

University Libraries & Learning Sciences Faculty and Staff Publications

Purpose

The purpose of this study was to investigate whether and in what ways library workers in the United States encountered patrons espousing beliefs in conspiracy theories and, if so, to explore the effectiveness of the strategies they used to address information disorder during the interactions.

Design/methodology/approach

The study was designed with an exploratory qualitative approach. Data were collected via an online survey posted to national and state library association listservs, utilizing a self-selected sampling method. Researchers inductively and deductively analyzed results, developing predetermined themes based on the research questions, then iteratively integrating unexpected data during coding.

Findings

A total …

Co-Delivery Of Therapeutics And Bioactive Gas Using A Novel Liposomal Platform For Enhanced Treatment Of Acute Arterial Injury, Shao-Ling Huang, Melanie R Moody, Xing Yin, David D Mcpherson, Hyunggun Kim

Faculty, Staff and Student Publications

Atherosclerosis is a complex, multi-stage disease characterized by pathological changes across the vascular wall. Endothelial dysfunction, inflammation, hypoxia, and vascular smooth muscle cell proliferation contribute to its progression. An effective strategy capable of delivering pleiotropic treatment to the vascular wall is essential to limit neointimal formation. Echogenic liposomes (ELIP), which can encapsulate bioactive gases and therapeutic agents, have the potential to deliver enhanced penetration and treatment efficacy for atherosclerosis. In this study, liposomes loaded with nitric oxide (NO) and rosiglitazone, a peroxisome proliferator-activated receptor agonist, were prepared using hydration, sonication, freeze-thawing, and pressurization. The efficacy of this delivery system was …

Raising A Bottle-Fed Calf On A Cow/Calf Operation, Reganne K. Briggs, Katelyn Barsnick, Cheyenne Reid, Ashley Longmore

All Current Publications

Having bottle-fed calves on the ranch is common for beef producers. The most likely scenarios are a cow has died, a cow isn’t giving enough milk, or a twin has been rejected. All these scenarios are likely to happen, which results in an orphan calf. Bottle-feeding a calf is straightforward; however, there are limited resources, specifically for beef producers, looking for bottle-fed calf management strategies. When bottle-feeding a beef calf, there are some things to consider, such as feeding colostrum, selecting and using milk replacers, and weaning the calf. Many of the resources on bottle-calf management come from the dairy …

Neonatal Abstinence Syndrome (Nas): What You Need To Know, Maren Wright Wright Voss, Amelia Van Komen, Emily Hamilton, Aarica Cleveland, Jaclyn Miller

All Current Publications

National overdose deaths continue to rise, with 2021 marking the first time U.S. overdose deaths topped 100,000 in a 12-month timeframe. Substance use, such as alcohol, cocaine, opioids, and marijuana, during pregnancy is also increasing. As the U.S. struggles with harmful substance use, a growing number of infants are born with neonatal abstinence syndrome (NAS), a harmful outcome of fetal exposure to substances. This fact sheet will talk about why and what to do, with recommendations for safe treatment and support during pregnancy.

Global Drivers Of Local Water Stresses And Global Responses To Local Water Policies In The United States, Iman Haqiqi, Laura Bowling, Sadia Jame, Uris Baldos, Jing Liu, Thomas Hertel

Department of Agricultural Economics Faculty Publications

The rapid depletion of US groundwater resources and rising number of dying wells in the Western USbrings attention to the significance of groundwater governance and sustainability restrictions. However, such restrictions on groundwater withdrawals are likely to generate spillover effects causing further environmental stresses in other locations and adding to the complexity of sustainability challenges. The goal of this paper is to improve our understanding of the implications of growing global food demand for local sustainability stresses and the implications of local sustainability policies for local, regional, and global food production, land use, and prices. We employ SIMPLE-G-US (Simplified International Model …

Using Mass Spectrometry Imaging To Map Fluxes Quantitatively In The Tumor Ecosystem, Michaela Schwaiger-Haber, Ethan Stancliffe, Dhanalakshmi S Anbukumar, Blake Sells, Jia Yi, Kevin Cho, Kayla Adkins-Travis, Milan G Chheda, Leah P Shriver, Gary J Patti

2020-Current year OA Pubs

Tumors are comprised of a multitude of cell types spanning different microenvironments. Mass spectrometry imaging (MSI) has the potential to identify metabolic patterns within the tumor ecosystem and surrounding tissues, but conventional workflows have not yet fully integrated the breadth of experimental techniques in metabolomics. Here, we combine MSI, stable isotope labeling, and a spatial variant of Isotopologue Spectral Analysis to map distributions of metabolite abundances, nutrient contributions, and metabolic turnover fluxes across the brains of mice harboring GL261 glioma, a widely used model for glioblastoma. When integrated with MSI, the combination of ion mobility, desorption electrospray ionization, and matrix …

The Influence Of Selected Personal And Academic Demographic Characteristics On Retention From Fourth To Fifth Semester Of Enrollment Among Traditional-Age Undergraduate Students At A Research Extensive University In The Southern Portion Of The United States, Tammy R. Millican

LSU Doctoral Dissertations

While many Americans may be questioning the value of a college degree due to rising costs, on virtually every measure of economic well-being and career attainment—from personal earnings to job satisfaction to the share employed full time—young college graduates are outperforming their peers with less education. Yet college dropout rates indicate that up to 32.9% of undergraduates do not complete their degree program, which has a financial impact on both students and the universities and colleges where they enroll (Hanson, 2022).

Historically, students who leave college before completing a baccalaureate degree are no better qualified than those with a high …

Mass Spectrometry Imaging Reveals Abnormalities In Cardiolipin Composition And Distribution In Astrocytoma Tumor Tissues, Anna C Krieger, Luis A Macias, J Clay Goodman, Jennifer S Brodbelt, Livia S Eberlin

Faculty, Staff and Students Publications

Cardiolipin (CL) is a mitochondrial lipid with diverse roles in cellular respiration, signaling, and organelle membrane structure. CL content and composition are essential for proper mitochondrial function. Deranged mitochondrial energy production and signaling are key components of glial cell cancers and altered CL molecular species have been observed in mouse brain glial cell xenograft tumors. The objective of this study was to describe CL structural diversity trends in human astrocytoma tumors of varying grades and correlate these trends with histological regions within the heterogeneous astrocytoma microenvironment. To this aim, we applied desorption electrospray ionization coupled with high field asymmetric ion …

Stakeholder Engagement In Urban Public Transportation Agencies In The United States, Tyler Joseph Wolfe

Dissertations and Theses

Major urban public transportation agencies in the United States are often under pressure to engage stakeholders in order to improve both the legitimacy and effectiveness of their transit systems. Based on qualitative methods of directed content analysis, this dissertation answers three related questions: (I) How do internal organizational qualities affect stakeholder engagement? (II) How do external socioeconomic factors affect stakeholder engagement? and (III) Does stakeholder engagement lead to better performance? Using a most similar comparative case study design, this research studies stakeholder engagement in five major urban public transportation agencies (Denver, Oklahoma City, Seattle, Portland, and Memphis). It demonstrates the …

Joint Effect Of Human Papillomavirus Exposure, Smoking And Alcohol On Risk Of Oral Squamous Cell Carcinoma, Zheng Yang, Peng Sun, Kristina R Dahlstrom, Neil Gross, Guojun Li

Faculty, Staff and Students Publications

BACKGROUND: Smoking, alcohol consumption, and human papillomavirus (HPV) infection are known risk factors for oral squamous cell carcinoma (OSCC) including SCC of oropharynx (SCCOP) and SCC of oral cavity (SCCOC). Researchers have examined each of these risk factors independently, but few have observed the potential risk of their interaction. This study investigated the interactions among these risk factors and risk of OSCC.

METHODS: Totally 377 patients with newly diagnosed SCCOP and SCCOC and 433 frequency-matched cancer-free controls by age and sex were included. Multivariable logistic regression was performed to calculate ORs and 95% CIs.

RESULTS: We found that overall OSCC …

Multi-Stakeholder Perspectives Regarding Preferred Modalities For Mental Health Intervention Delivered In The Orthopedic Clinic: A Qualitative Analysis, Abby L Cheng, Ashwin J Leo, Ryan P Calfee, Christopher J Dy, Melissa A Armbrecht, Joanna Abraham

2020-Current year OA Pubs

BACKGROUND: Although depressive and anxious symptoms negatively impact musculoskeletal health and orthopedic outcomes, a gap remains in identifying modalities through which mental health intervention can realistically be delivered during orthopedic care. The purpose of this study was to understand orthopedic stakeholders' perceptions regarding the feasibility, acceptability, and usability of digital, printed, and in-person intervention modalities to address mental health as part of orthopedic care.

METHODS: This single-center, qualitative study was conducted within a tertiary care orthopedic department. Semi-structured interviews were conducted between January and May 2022. Two stakeholder groups were interviewed using a purposive sampling approach until thematic saturation was …

Selecting The Optimal Formwork System For Horizontal Elements, Alaa Allam, Emad Elbeltagi, Mohamed Naguib Abouelsaad, Mohamed E. El Madawy

Mansoura Engineering Journal

Various types of formworks are available in the market for construction of cast-in-place concrete structures. Formwork has a significant impact on both construction time and cost. As such, decision making on the optimal formwork system is difficult and timeconsuming for designers or planners particularly for high-rise buildings, where any reduction in the cost of single-story formwork significantly decrease total construction cost. Formworks must be designed effectively as numerous accidents have happened as a result of poor design decisions. This article presents a Genetic Algorithm optimization model to select the optimal formwork system among Cuplock, Shore brace and Props systems that …

Chat Gpt: Revolutionizing Communication Or Threatening Authenticity?, Anubhav Mishra, Saumya Awasthi

Management Dynamics

No abstract provided.

The “Deliberate Indifference” Standard Of Mental Health Care: How It Fails Unaccompanied Minors Seeking Asylum, Karina Virk

Penn State Journal of Law & International Affairs (2012 - Present)

No abstract provided.

Must China Pay? How Claims Against China For Covid-19 Reveal Flaws In The International Legal System That Make Accountability Impractical, Talia Danielle Sturkie

Penn State Journal of Law & International Affairs (2012 - Present)

No abstract provided.

Semi-Presidentialism: A Pathway To Democratic Backslide, Connor Mcafee

Penn State Journal of Law & International Affairs (2012 - Present)

No abstract provided.

A Path For Cooperation Between Law Schools In China And The United States, Bryant Walker Smith, Ying Wang, Leighton Carlock, Karman Lucero

Penn State Journal of Law & International Affairs (2012 - Present)

No abstract provided.

Enforcing Arbitral Awards Against States And The Defense Of Sovereign Immunity From Execution: A U.S. Perspective, Ylli Dautaj

Penn State Journal of Law & International Affairs (2012 - Present)

No abstract provided.

The Jus Ad Bellum In Cyberspace: A New Framework, M. Walker Brunner

Penn State Journal of Law & International Affairs (2012 - Present)

No abstract provided.

Taking Exception To Criminal Justice Reforms That Fail To Transform: Using Transitional Justice To End The Carceral State, Angela A. Allen-Bell

Penn State Journal of Law & International Affairs (2012 - Present)

No abstract provided.

Foreword

Penn State Journal of Law & International Affairs (2012 - Present)

No abstract provided.

Dedication

Penn State Journal of Law & International Affairs (2012 - Present)

No abstract provided.

Forgoing The "Rule Of Five" : Fair Use Analysis In Interlibrary Loan And Collection Development, Linda Sizemore, Ashley Cole

OVGTSL 2023: Ongoing Challenges, Creative Solutions

Are you being bogged down by copyright? Are you getting all the access you deserve? Eastern Kentucky University Libraries recently developed and implemented a new copyright policy for interlibrary loan that forgoes the outdated CONTU Guidelines or "Rule of Five" to more closely comply with Copyright Law and leverage Fair Use.

In this session, the presenters will discuss the inspiration behind abandoning CONTU, the process for obtaining approval from library and university stakeholders, and the impact of a new copyright policy on interlibrary loan workflows and collection development decisions. Participants will also engage in a discussion of the opportunities and …

Authority Control: It's Not Just For Catalogers, Carl Horne

OVGTSL 2023: Ongoing Challenges, Creative Solutions

This presentation will discuss the importance of authority control of access points in the library's online catalog. Authority control, by means of a file of authority records, is the linchpin of a well-ordered catalog - it is the means of creating and maintaining standardized access points throughout the file of bibliographic records. It is this good order that makes searching in the catalog efficient. The importance of authority control is a matter that Technical Services, and especially catalogers, need to impress on public services and other librarians across the organization, because non-catalogers sometimes view authority work as a luxury, or …

Patron Driven Dei Acquisitions: Using Education Students And The Diverse Book Finder To Diversify A Children's Picture Book Collection, Mitchell Scott

OVGTSL 2023: Ongoing Challenges, Creative Solutions

In Fall 2022, the IU Southeast Library won an institutional Diversity, Equity, and Inclusion grant to conduct research on a patron driven acquisitions project carried out in a 300-level education course for preservice learning teachers. Leveraging the grant funds and the objectives of the 300-level course, we embedded an acquisition project into the course that used the Diverse Book Finder (DBF) as a teaching and selection tool. 29 students enrolled in the course were tasked with using the Diverse Book Finder to select 5 picture books that would be purchased and added to the library collection. This session will cover …

Print Government Documents: Working Together To Eliminate Your Print Documents (With Empathy), Claudene Sproles, Tyler Goldberg

OVGTSL 2023: Ongoing Challenges, Creative Solutions

Ekstrom Library collected print government documents for decades as a selective depository. We will discuss our process for weeding hundreds of print documents collection from the collection. What are the reasons for weeding? Where can you find digital copies? What is the process for exchanging documents, and how many are really being requested by other depository libraries? What is the current state of depository rules and procedures?

The Spectrum Of Severity In 368 Patients With Metopic Craniosynostosis: An Update To The Craniorate™ Machine Learning Algorithm, Annie Glenney, Joseph Mocharnuk, Griffin Bins, Erin Anstadt, Lucas Dvoracek, Wenzheng Tao, Ross Whitaker, Lisa David, David Runyan, Jesse Goldstein

St. Chris Research Day

No abstract provided.

Impact Of An Education Specialist On The Care Of Children With Hearing Loss, Leona J. Tu Bs, Nicole Miranda Bs, Carrie Brollier Ms, Michael S. Cohen Md

St. Chris Research Day

No abstract provided.

Association Of Patient Insurance Status With Discharge Outcomes Among Children Hospitalized With Acute Traumatic Brain Injury, Aisha Bosula

St. Chris Research Day

No abstract provided.