Digital Commons Network^™

Creating Systemic Support: Cross-Sector Partnerships As A Catalyst To Institutional Transformation For Southeast Asian Student Support, Brianna Lourdes Edoria Pascua

Master's Projects and Capstones

This paper investigates the potential impact of cross-sector partnerships between nonprofit organizations (NPOs) and universities on the educational attainment of Southeast Asian American (SEAA) students, particularly those from disenfranchised or nontraditional backgrounds. Guided by the research question, "Can cross-sector partnerships between NPOs and universities contribute to increased educational attainment among SEAA students?", the study seeks to comprehensively explore SEAA student experiences, challenge the Model Minority Stereotype, enrich SEAA higher educational achievement literature, underline the significance of disaggregated data and cross-sector collaborations, and create an adaptable framework for other communities. By adopting an Asian Critical Race Theory (AsianCrit) lens, the research …

Burnout: An Examination Of How Human Services’ Cultures Impact Person-Centered Care And Job Satisfaction, Ebony Webb

Master's Projects and Capstones

In a world that demands the constant requirement of adaptability and technology, the need for ‘hands on the ground’ continues to persist, and perhaps even grow. This research project explores burnout in the healthcare and nonprofit settings, as a pre-existing and ongoing issue, that was brought to centre-stage during the Covid-19 pandemic. The researcher explores the intersections of burnout with workplace culture, person-centered care (PCC), sweat equity and duty-of-care, through expert interviews and literature reviews. Data collected provides an immediate understanding of current workplace cultures and environments for human service providers, in both healthcare and nonprofit sectors. While the data …

Carbon Free Colorado: An Integrated Resource Plan For The Public Service Company Of Colorado 2020-2050, Vignesh Devaki Murugesan, Adam Lokar

Master's Projects and Capstones

This Integrated Resource Plan (IRP) outlines the Public Service Company of Colorado’s (PSCo) strategy to accommodate the growing energy demand of its customers while transitioning to renewable energy. The IRP attempts to quantify the impact of Colorado’s clean energy and climate policy by comparing three different scenarios:

1. Reference Scenario. New capacity is met with the lowest cost of generation ignoring Colorado Renewable Energy Standard.

2. 100% Carbon Free by 2050. Additional capacity is met with lowest cost mix of renewables sufficient to meet Colorado’s Renewable Energy Standard.

3. High Electrification. Adheres to Colorado’s Renewable Energy Standard while also accommodating …

Phase Ii Clinical Trial Of Axitinib And Avelumab In Patients With Recurrent/Metastatic Adenoid Cystic Carcinoma, Renata Ferrarotto, Luana G Sousa, Lei Feng, Frank Mott, George Blumenschein, Mehmet Altan, Diana Bell, Flavia Bonini, Kaiyi Li, Mario L Marques-Piubelli, Eduardo A Dal Lago, Jason J Johnson, Yoshitsugu Mitani, Myrna Godoy, Anna Lee, Michael Kupferman, Ehab Hanna, Bonnie S Glisson, Yasir Elamin, Adel El-Naggar

Faculty, Staff and Student Publications

Purpose: We conducted a phase II trial evaluating the efficacy of VEGFR inhibitor axitinib and PD-L1 inhibitor avelumab in patients with recurrent/metastatic adenoid cystic carcinoma (R/M ACC).

Patients and methods: Eligible patients had R/M ACC with progression within 6 months before enrollment. Treatment consisted of axitinib and avelumab. The primary end point was objective response rate (ORR) per RECIST 1.1; secondary end points included progression-free survival (PFS), overall survival (OS), and toxicity. Simon's optimal two-stage design tested the null hypothesis of ORR ≤5% versus ORR ≥20% at 6 months; ≥4 responses in 29 patients would reject the null hypothesis.

Results: …

Magrolimab In Combination With Azacitidine In Patients With Higher-Risk Myelodysplastic Syndromes: Final Results Of A Phase Ib Study, David A Sallman, Monzr M Al Malki, Adam S Asch, Eunice S Wang, Joseph G Jurcic, Terrence J Bradley, Ian W Flinn, Daniel A Pollyea, Suman Kambhampati, Tiffany N Tanaka, Joshua F Zeidner, Guillermo Garcia-Manero, Deepa Jeyakumar, Rami Komrokji, Jeffrey Lancet, Hagop M Kantarjian, Lin Gu, Yajia Zhang, Anderson Tan, Mark Chao, Carol O'Hear, Giridharan Ramsingh, Indu Lal, Paresh Vyas, Naval G Daver

Faculty, Staff and Student Publications

Purpose: Magrolimab is a monoclonal antibody that blocks cluster of differentiation 47, a don't-eat-me signal overexpressed on cancer cells. Cluster of differentiation 47 blockade by magrolimab promotes macrophage-mediated phagocytosis of tumor cells and is synergistic with azacitidine, which increases expression of eat-me signals. We report final phase Ib data in patients with untreated higher-risk myelodysplastic syndromes (MDS) treated with magrolimab and azacitidine (ClinicalTrials.gov identifier: NCT03248479).

Patients and methods: Patients with previously untreated Revised International Prognostic Scoring System intermediate-/high-/very high-risk MDS received magrolimab intravenously as a priming dose (1 mg/kg) followed by ramp-up to a 30 mg/kg once-weekly or once-every-2-week …

Efficacy Of A Smoking Cessation Intervention For Survivors Of Cervical Intraepithelial Neoplasia Or Cervical Cancer: A Randomized Controlled Trial, Jennifer I Vidrine, Steven K Sutton, David W Wetter, Ya-Chen Tina Shih, Lois M Ramondetta, Linda S Elting, Joan L Walker, Katie M Smith, Summer G Frank-Pearce, Yisheng Li, Sarah R Jones, Darla E Kendzor, Vani N Simmons, Damon J Vidrine

Faculty, Staff and Student Publications

PURPOSE: Women who smoke and have a history of cervical intraepithelial neoplasia (CIN) or cervical cancer represent a vulnerable subgroup at elevated risk for recurrence, poorer cancer treatment outcomes, and decreased quality of life. The purpose of this study was to evaluate the long-term efficacy of Motivation And Problem Solving (MAPS), a novel treatment well-suited to meeting the smoking cessation needs of this population.

METHODS: Women who were with a history of CIN or cervical cancer, age 18 years and older, spoke English or Spanish, and reported current smoking (≥100 lifetime cigarettes plus any smoking in the past 30 days) …

Insight Into The Desolvation Of Quaternary Ammonium Cation With Acetonitrile As A Solvent In Hydroxyl-Flat Pores: A First-Principles Calculation, Fudong Liu, Shaobin Yang, Xu Zhang, Shuwei Tang, Yingkai Xia

Faculty, Staff and Student Publications

Supercapacitors have a wide range of applications in high-technology fields. The desolvation of organic electrolyte cations affects the capacity size and conductivity of supercapacitors. However, few relevant studies have been published in this field. In this experiment, the adsorption behavior of porous carbon was simulated with first-principles calculations using a graphene bilayer with a layer spacing of 4-10 Å as a hydroxyl-flat pore model. The reaction energies of quaternary ammonium cations, acetonitrile, and quaternary ammonium cationic complexes were calculated in a graphene bilayer with different interlayer spacings, and the desolvation behavior of TEA+ and SBP+ ions was described. The critical …

Toll-Like Receptors 2, 4, And 9 Modulate Promoting Effect Of Copd-Like Airway Inflammation On K-Ras-Driven Lung Cancer Through Activation Of The Myd88/Nf-ĸb Pathway In The Airway Epithelium, Walter V Velasco, Nasim Khosravi, Susana Castro-Pando, Nelly Torres-Garza, Maria T Grimaldo, Avantika Krishna, Michael J Clowers, Misha Umer, Sabah Tariq Amir, Diana Del Bosque, Soudabeh Daliri, Maria Miguelina De La Garza, Marco Ramos-Castaneda, Scott E Evans, Seyed Javad Moghaddam

Faculty, Staff and Student Publications

INTRODUCTION: Toll-like receptors (TLRs) are an extensive group of proteins involved in host defense processes that express themselves upon the increased production of endogenous damage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns (PAMPs) due to the constant contact that airway epithelium may have with pathogenic foreign antigens. We have previously shown that COPD-like airway inflammation induced by exposure to an aerosolized lysate of nontypeable

METHODS: In the present study, we have dissected the role of TLRs in this process by knocking out TLR2, 4, and 9 and analyzing how these deletions affect the promoting effect of COPD-like airway inflammation on …

Teacher Perceptions On The Influence Of The Amistad Integrated Units On Instructional Practices And Black Female Students' Academic Experiences, Tiffany Wicks

Seton Hall University Dissertations and Theses (ETDs)

ABSTRACT

The purpose of this study is to understand the thoughts of teachers on the Amistad Integrated Units and the influence of the culturally relevant units on Black female students. The researcher identified if culturally relevant pedagogy influenced teacher instructional practices and the classroom academic experiences of Black female students. The findings helped to explain the needs of Black girls in an urban classroom and possible solutions that can benefit them within classroom environments.

For this study, the researcher used a narrative inquiry research design to examine and understand the perspectives of teachers and the influence of culturally relevant curriculum …

Black Males’ Self-Efficacy And College Attendance: A Quantitative Study, Shawanda Beale

Seton Hall University Dissertations and Theses (ETDs)

This study will investigate the relationship between Black males’ self-efficacy, college aspirations, and college attendance. Researchers have examined self-efficacy among racial groups and gender (Richardson et al., 2013). Yet, the researcher is interested in examining factors that relate to Black males aspiring to and attending college and the role of self-efficacy in those relationships. Self-efficacy involves belief in one’s ability to accomplish goals (Bandura, 1997). Self-efficacy helps students see themselves as capable of achieving goals. Students with higher self-efficacy develop action plans to attend college, and students with lower self-efficacy are less likely to develop action plans to attend college. …

Understanding Community College Transfer Student Experiences: Academic And Social Engagement At A Private Four-Year Institution, Hezal Patel

Seton Hall University Dissertations and Theses (ETDs)

The purpose of this study was to understand the academic and social engagement experiences of community college transfer students at a private four-year institution. Approached through the lens of a conceptual critical framework for transfer student research advanced by Laanan and Jain (2017), and using a qualitative narrative methodology, this study collected the stories of 12 community college transfer students attending a private four-year institution to understand their engagement experiences. Restorying participants’ narratives and multiple rounds of coding including: deductive coding, open and in vivo coding and process coding revealed the findings for this study. The findings indicate that individuals’ …

Fever Dive: A Novel, Sofia Ohrynowicz

Seton Hall University Dissertations and Theses (ETDs)

This is the craft reflection, prologue, and first five chapters of Fever Dive, a novel in progress.

Photoisomerizable Membrane Active Peptides, Cristina Ventura

Seton Hall University Dissertations and Theses (ETDs)

Membrane active peptides (MAPs) bind and partition into the cell membrane thus causing permeabilization. Many α-helical membrane active peptides contain central proline residues that distinguish the hydrophobic and hydrophilic faces of the helix. The proline induces a bend that produces a helix-hinge-helix motif. Mutation of these proline residues has a significant effect on the activity of the MAP. Azobenzene is a photoisomerizable molecule that switches from its trans to cis isomer upon excitation with ultraviolet (UV) light and from its cis to trans isomer upon excitation with visible light (VL). In this work it is hypothesized that the hinge function …

First-Year Engagement And Intention To Return In Higher Education: A National Study Of Undecided Major Students, Jacqueline Galler

Seton Hall University Dissertations and Theses (ETDs)

Research suggests that a student’s persistence in higher education is influenced by their academic preparation, commitments, and involvement, (Tinto 2005). Predictors including student demographics, academic preparation and commitments have shown in previously studies to affect the rate at which students persist in higher education, (Pascarella & Terenzini 2005, Astin & Oseguera 2005, Terenzini & Reason 2005). Involvement at an institution contributes to a students’ engagement and intent to persist in higher education or at a specific institution. Researchers have found that students engage in the university, academically and socially, based on how their values align with the institution, feedback they …

Digitizing The American West: Analyzing Rhetoric In Red Dead Redemption 2, Amalia Mcevoy

Seton Hall University Dissertations and Theses (ETDs)

High-budget, long-form storytelling games offer dozens of hours of content for audiences to explore and learn from. Although far different from sitting and reading a book, there is a distinct connection to be made between how literature is experienced and how audiences can experience a narrative-heavy video game. Based on this connection, there are bridges to be built between video games and literature, understanding how one field can benefit from the other as well as how one field can be informed by the other. An analysis of the video game Red Dead Redemption 2 using reader response theory can illustrate …

The Old And New Divides Of Patent Law: From The Theory Of Antedation To Defining Immediately Envisageable Limited Classes, Condon, Eamon M.

Santa Clara High Technology Law Journal

Recently, the United States Court of Appeals for the Federal Circuit (“Federal Circuit”) ruled on a patent case involving the application of pre-America Invents Act (“AIA”) antedation and the issue of when a genus of compounds is narrowly limited enough to anticipate an individual compound found within the genus.1 On appeal, this case generally discussed why the claimant’s anticipation and obviousness claims failed.2

While the entire Federal Circuit decision will be discussed, this Comment will discuss in greater depth the reasons why antedation is no longer applicable under the AIA, and the implications of the Federal Circuit’s decision to not …

Anna Mae Childers

African American Funeral Programs

No abstract provided.

Journalism On Forced Migration In Latin America: Recommendations From Experts And International Journalism Guides From A Qualitative Study, Gabriel Lotero-Echeverri, Luis M. Romero-Rodríguez

The Qualitative Report

Wars, insurgent groups, dictatorships, and economic crises are the main reasons for forced migration. Displaced persons, asylum seekers, and refugees often face public stigmatization, as they are treated by the media as a social problem and, in many cases, seen as economic and social threats. This article presents the results of in-depth interviews with expert journalists and researchers from different Latin American countries on the phenomenon of forced migration and its journalistic coverage. Their recommendations are complemented by Qualitative Document Analysis (QDA) of international guides on migration journalism. The findings highlight the need for training and awareness-raising in critical skills …

Community Gatekeepers: Power, Pitfalls And Possibilities When Recruiting And Researching Black, Asian, And Minority Ethnic (Bame) Participants, Nadia K. Bashir

The Qualitative Report

Using data from a large primarily qualitative research project on how people from Black, Asian and Minority Ethnic (BAME) communities experience and access health services, this methodological article focuses on the role of the community gatekeeper – a role that has significance for research teams globally when attempting to involve those facing multiple forms of exclusion. Drawing on standpoint feminist principles and using a reflexive approach, researcher positionality, situated knowledges, and the power dynamics between researchers, participants, and community gatekeepers are reflected upon. Addressing a gap in the literature by providing real-life examples of the power and influence of gatekeepers …

Balancing The Drinking Act: A Grounded Theory Of Youth Drinking, Policy And Covid-19 In Botswana, Tebogo Sebeelo

The Qualitative Report

Stakeholder and consumer participation is generally seen as a critical part of effective alcohol policy making as it has a direct impact on policy implementation. In the advent of COVID-19, the views and experiences of stakeholders and consumers were integral to how countries responded to the virus. The involvement of alcohol stakeholders and consumers raises critical questions about policy making practices. Using Grounded Theory (GT) methods amongst 20 drinkers and six alcohol stakeholders, I examined the views and experiences of stakeholders and alcohol consumers in Botswana during COVID-19. I identified two interrelated core categories of Balancing the Drinking Act and …

Writing With Pleasure: A Review, Kathryn Roulston

The Qualitative Report

As long as there have been writers, they have given advice to others on writing. Numerous academic and non-academic writers have contributed advice on how to create a writing life, how to write well, and how to get published. Much of this literature aims to assist writers through the challenges encountered in the writing process. Helen Sword’s book, Writing with Pleasure, takes an atypical approach to writing by showing readers how they can create their own action plan to write with pleasure. Suited to novice and experienced writers, Sword’s book provides practical strategies for creating and sustaining a writing practice …

Hiv-1 Transmission Among Injecting Drug Users Is Principally Derived From Local Circulating Strains In Guangxi, China, Ping Cen, Hua Yue Liang, Yuan Yang, Fei Zhang, Shi Xiong Yang, Ju Cong Mo, Yi Feng, Jie Gang Huang, Chuan Yi Ning, Chun Yuan Huang, Yao Yang, Na Liang, Bing Yu Liang, Li Ye, Hao Liang

Faculty, Staff and Student Publications

OBJECTIVE: The mode of human immunodeficiency virus (HIV) transmission

METHODS: We performed a molecular epidemiological investigation of infections across Guangxi from 2009 to 2019. Phylogenetic and Bayesian time-geographic analyses of HIV-1 sequences were performed to confirm the characteristics of transmission between IDUs in combination with epidemiological data.

RESULTS: Among the 535 subjects, CRF08_BC (57.4%), CRF01_AE (28.4%), and CRF07_BC (10.7%) were the top 3 HIV strains; 72.6% of infections were linked to other provinces in the transmission network; 93.6% of sequence-transmitted strains were locally endemic, with the rest coming from other provinces, predominantly Guangdong and Yunnan; 92.1% of the HIV transmission …

Nursing Education In Complementary Alternative Modalities: A Case Study, Deborah Bird

Dissertations

Purpose: The purpose of this embedded case study was to describe the preparation for and utilization of complimentary alternative modality (CAM) interventions by an experienced Doctor of Nursing Practice (DNP) prepared nurse practitioner (NP) working in an outpatient setting.

Background: Given the widespread use of CAM by the American public and the potential complications involved in combining CAM and standard medical care, a lack of educational preparation in CAM interventions by NPs delivering primary care in outpatient health care settings represents both a potential risk and a missed opportunity to provide holistic patient care. Such a lack of knowledge also …

Addressing Funding Disparities In Women Of Color-Led Organizations, Christy J. Thomas

Master's Projects and Capstones

Women of color who are founders and/or leaders of nonprofit organizations typically come from the communities they serve. While their experience within their communities gives them an edge on service delivery and impact, these leaders face funding disparities compared to other organizations. This report highlights the stories and experiences of three women of color founders and nonprofit leaders to provide insight into the funding barriers and how to mitigate these barriers. Suggestions for improvement include Trust based philanthropy, listening sessions, and Women of color-leader development circles.

Biomodd: The Integration Of Art Into Transdisciplinary Research Practices, Ulrike Kuchner, Mona Nasser, Pieter Steyaert, Diego S. Maranan, Zeynep Birsel, Agatha Haines, Ann Peeters, Angelo C.J. Vermeulen

More Faculty of Health Research

Biomodd is an artistic project with the potential for supporting transdisciplinary practices in blended virtual and in-person environments. After describing the project components, we discuss the collaborative process of idea generation and participant engagement. In this paper, we argue for the integration of collaborative art practice in transdisciplinary (TD) research to generate ideas and engage researchers and non-academic stakeholders. We draw on the virtual and in-person (hybrid) participation of members of the TD collective Space Ecologies Art and Design (SEADS) during Biomodd, an art installation that addresses global challenges in ecology, humanity, technology, and technological waste. Using survey responses, diaries, …

Bovine Herpesvirus-4 Based Vaccine Provides Protective Immunity Against Streptococcus Suis Disease In A Rabbit Model, Nihua Dong, Hester Nichols, Q Sun, Xiaojun Chen, Jiayang Zheng, Zhixin Guan, Hailong Zhang, Andrew Davison, Yvonne Wezel, Z Li, B Li, Ke Liu, Donghua Shao, Yafeng Qiu, J Sun, Xiangdong Li, Mathew Upton, Zhiyong Ma, Michael A. Jarvis, Jianchao Wei

School of Biomedical Sciences

Streptococcus suis (S. suis) is a bacterial pathogen of pigs that has a major animal health and economic impact on the pig industry. Bovine herpesvirus-4 (BoHV-4) is a new virus-based vaccine vector that has been used for the immunogenic delivery of antigens from a variety of pathogens. In the present study, two recombinant BoHV-4-based vectors were evaluated for their ability to induce immunity and protection against S. suis in a rabbit model. The GMD protein is a fusion protein consisting of multiple dominant B-cell epitopes ((B-cell dominant epitopes of GAPDH, MRP, and DLDH antigens) (BoHV-4/GMD)) and the second suilysin (SLY) …

Ocean Circulation And Biological Processes Drive Seasonal Variations Of Dissolved Al, Cd, Ni, Cu, And Zn On The Northeast Atlantic Continental Margin, Xue Gang Chen, Dagmara Rusiecka, Martha Gledhill, Angela Milne, Amber L. Annett, Antony J. Birchill, Maeve C. Lohan, Simon Ussher, E. Malcolm S. Woodward, Eric P. Achterberg

School of Geography, Earth and Environmental Sciences

Nutrients and nutrient-like dissolved trace metals (dTMs) are essential for the functioning of marine organisms and therefore form an important part of ocean biogeochemical cycles. Here, we report on the seasonal distributions of dissolved zinc (dZn), nickel (dNi), copper (dCu), cadmium (dCd), aluminum (dAl), and nutrients on the Northeast Atlantic continental margin (Celtic Sea), which is representative for temperate shelf seas globally. Variations in surface water dTM and nutrient concentrations were mainly regulated by seasonal changes in biological processes. The stoichiometry of dTMs (especially for dCu and dZn) and nutrients on the continental shelf was additionally affected by fluvial inputs. …

Trends Over 20 Years Of Antimicrobial Prophylaxis For Artificial Urinary Sphincter Surgery, Helen H. Sun, Michael Callegari, Eric Zhou, Erin Jesse, Megan Prunty, Jonathan E. Shoag, Kyle Scarberry, Kirtishri Mishra, Shubham Gupta

Faculty Scholarship

Introduction and Objective: Perioperative antimicrobial prophylaxis is crucial for prevention of prosthesis and patient morbidity after artificial urinary sphincter (AUS) placement. While antibiotic guidelines exist for many urologic procedures, adoption patterns for AUS surgery are unclear. We aimed to assess trends in antibiotic prophylaxis for AUS and outcomes relative to American Urological Association (AUA) Best Practice guidelines. Methods: The Premier Healthcare Database was queried from 2000 to 2020. Encounters involving AUS insertion, revision/removal, and associated complications were identified via ICD and CPT codes. Premier charge codes were used to identify antibiotics used during the insertion encounter. AUS‐related complication events were …

Facilitators And Barriers To Effective Scale-Up Of Evidence-Based Nonprofit-Level Hiv Prevention And Treatment Interventions Among Black Men Who Have Sex With Men (Msm), Ugochukwu C. Uzoeghelu

Master's Projects and Capstones

Since the scale-up of HIV/AIDS prevention evidence-based interventions (EBIs) has not been simple in nonprofit settings, it is crucial to examine processes that occur in the translation of the EBIs into practice that affect successful implementation through the lens of nonprofit principles and practices. This paper examines the facilitators and barriers to effective scale-up of evidence-based HIV prevention and treatment services for nonprofit health organizations that serve Black men who have sex with men (MSM). I interviewed nonprofit health organizations (n = 4) engaged in the global response to end the HIV epidemic, specifically those who provide HIV prevention and …

A New Pipeline: Building A Transformative Leadership Pipeline For Formerly Incarcerated Individuals, Jackie Aguilar

Master's Projects and Capstones

While developing leadership roles for employers is critical to running an effective organization, building a bridge for those who have directly lived experiences regarding its mission is critical. Bringing back community members you have served to your organization is highly recommended and essential. This capstone research report will focus on building a leadership pipeline for formerly incarcerated individuals within the nonprofit sector. Returning community members can often be tokenized and are never given the tools and resources to develop as a leader. This report will outline the barriers formerly incarcerated individuals face while providing a foundation on the importance of …