Digital Commons Network^™

Feeling Otherwise: Affective Enactments Of Teaching And Learning Among Youth Researchers And Early-Career Teachers In A Cross-Course University Collaboration, Karen Zaino

Dissertations, Theses, and Capstone Projects

This study examines a cross-collaboration between early-career teachers enrolled in a graduate action research class and youth researchers taking part in a dual-enrollment youth participatory action research (YPAR) class at the same university. Grounded in critical youth studies, anti-colonial theories of the human, and queer-feminist studies in its approach to relationality, and drawing from transcripts of the combined class sessions and individual follow-up interviews, this critical narrative analysis seeks to understand how participants enact and experience the collaboration, with particular attention to how they understand and engage with one another. This study especially attends to the affective-discursive practices that participants …

Economic Factors And Theories Of Decline And Reform In The Late Ottoman Empire C. 1789–1911, Peter S. Gomori

Dissertations, Theses, and Capstone Projects

Tribes of Turkish speaking people (“Turks”) migrated in the 11th century from the Central Asian Steppes to what we consider the Middle East. Over the next two centuries this community would expand north, west and south to form a vast empire: the Ottoman Empire. Possibly the peak of the size of this empire would probably occur during the 16^th century under the rule of the Sultan, Suleiman the Magnificent (1494- 1566) where the population of the Ottoman Empire was estimated to be up to 30 million. Yet there would be rivals. To the East was the Safavid Empire (today …

A Critical Study Of Contemporary Palestinian Musical Culture, Karl H. Hausmann

Dissertations, Theses, and Capstone Projects

This study is concerned with the field of musical culture and practice in Palestine, and the connotations of musical expression, whether as music or songs. It addresses the period extending from the end of the seventies and the beginning of the eighties, through the first intifada of 1987 and then the era of the Oslo Accords until today.

This study deals with the artistic meanings and expressions associated with the music and singing that was produced in that period, assuming that it was created within the socio-political context in which it existed, specifically that music that was associated with the …

Barriers To Optimal Audiological Care For Members Of The Deaf Community, Joyce Orenshein

Dissertations, Theses, and Capstone Projects

Background:

The purpose of this study was to identify the barriers to optimal audiological care for members of the Deaf community from the perspectives of Deaf individuals compared to audiologists. The goal is to help bridge the clinical communication barriers that lie between audiologists and the Deaf community by identifying the perceived gaps in care specifically and by gathering suggestions for improvement. A survey was administered to both audiologists and members of the Deaf community, making the present study unique and essential in that responses from both communities are compared and suggestions for bridging the gap are made.

Methods …

The Persephone Series: Storytelling, Art, And Making Sense Of Myself, Katie M. Frank

Dissertations, Theses, and Capstone Projects

What can I do with what I already have? How can I make of it something beautiful, or useful, or interesting? Over the past two and a half years, I have been creating wall sculptures and collages out of found objects that speak to the history of my family, the way the earth reclaims its space after being used by humans, and how our individual lives have impact beyond our recognition. The people we love, the things we have lost, the garbage and grief we try to bury: it doesn’t go away. It comes back to the surface in shapes …

Reviews Of Applications For Smartphone-Connected Hearing Aids And Implications On Counseling, Rebecca Strong

Dissertations, Theses, and Capstone Projects

With the recent rise of smartphone ownership, more applications have been created that connect user’s hearing aids to their smartphone. One type of application that has become popular is one that allows the user to control hearing aids using a smartphone. While these applications have many benefits for the user, there has been very little research on the experiences of individuals using these applications. In order for audiologists to best help their patients troubleshoot and prepare reasonable expectations for using smartphone-connected hearing aids, they need to understand the patient experience to create effective solutions. One technique that can be used …

Bi Erasure And Bi Invisibility In Media And Medicine: Moving Beyond, Lacy M. Telles

Dissertations, Theses, and Capstone Projects

This project examines the bisexual erasure and invisibility that is found in film, television, literature, and in the field of reproduction. Even though bisexual people make up a large portion of the LGBTQ community, because of bi invisibility, they tend to get lost in the cause. This website offers information about bi invisibility, highlights obstacles faced by bisexuals, provides resources for bisexuals, and includes some fun topics for bisexual people. It also has a page of bisexual testimonies: real bi people with real bi stories. There is evidence of erasure and invisibility, especially in children’s books and the field of …

Caring For Individuals Who Are Experiencing Homelessness: An Audiologist’S Toolkit, Jenna Marie Sparacio

Dissertations, Theses, and Capstone Projects

National-level counts for individuals experiencing homelessness have been steadily on the rise. People experiencing homelessness face extraordinary barriers and challenges in accessing health care services, including hearing healthcare. Additionally, there is a high prevalence of self- reported hearing difficulties and hearing handicap among people experiencing homelessness. Hearing loss status and management is often not prioritized in healthcare settings, and treatment plans are not typically modified to best address the hearing needs of individuals who are homeless. This evidence-based toolbox for audiologists was developed to help understand and mediate healthcare barriers that people experiencing homelessness face, as well as to help …

Dementias Among Older Males And Females In The U.S. Medicare System With And Without Hiv, Xiaoying Yu, Yong-Fang Kuo, Mukaila A Raji, Abbey B Berenson, Jacques Baillargeon, Thomas P Giordano

Faculty, Staff and Students Publications

Background: Despite the growing concern that people with HIV (PWH) will experience a disproportionate burden of dementia as they age, very few studies have examined the sex-specific prevalence of dementia, including Alzheimer disease and related dementias (AD/ADRD) among older PWH versus people without HIV (PWOH) using large national samples.

Methods: We constructed successive cross-sectional cohorts including all PWH aged 65+ years from U.S. Medicare enrollees and PWOH in a 5% national sample of Medicare data from 2007 to 2019. All AD/ADRD cases were identified by ICD-9-CM/ICD-10-CM diagnosis codes. Prevalence of AD/ADRD was calculated for each calendar year by sex-age strata. …

Jus Soli And Jus Sanguinis: Politics, Race, Culture, And Citizenship In The Dominican Republic And Haiti, Guido A. Proano

Dissertations, Theses, and Capstone Projects

The promulgation of laws such as the Dominican Republic’s Constitutional Court’s Judgment TC-168-13 serves as a basis upon which to argue the major impediments presented by the Dominican government to deny Haitians and Dominicans of Haitians descent citizenship. The right to citizenship is based on legal principles of jus soli and jus sanguinis and is recognized in a series of international legal documents. Following a Marxist framework, this research demonstrates the uncounted possible relationships between modern social forces and politics that have been working closely following European productions of knowledge for decades against Haitians and Dominicans of Haitian descent in …

Emancipatory And Retributive Labor: Conflicting Representations Of Enslaved Labor In Us And Caribbean Literature, 1830–1855, Michael Druffel

Dissertations, Theses, and Capstone Projects

Emancipatory and Retributive Labor follows the development of a concept that I call emancipatory labor as it appeared in the US and Caribbean during the period 1830 to 1855. Emancipatory labor is a subversive tactic in which enslaved people in the United States and Caribbean redefined a portion of their labor in capitalist terms. Re-theorizing a portion of enslaved labor stakes a claim to agency and humanity according to Western, humanistic logic. Examples of the types of labor being redefined include selling commodities, hiring time, and working “extras” for wages. I use enslaved person Lunsford Lane’s 1842 narrative as a …

Targets And Study Design For Symptom-Focused Trials Aimed At Patients With Cirrhosis: An Expert Consensus, Arpan A Patel, Elliot B Tapper, Fasiha Kanwal, Christopher D Woodrell, Lissi Hansen, Jennifer C Lai, Shari Rogal, Cara Mcdermott, Mina Rakoski, Nneka N Ufere

Faculty, Staff and Students Publications

BACKGROUND: Symptom-focused trials are critically needed for patients with cirrhosis. However, this work would benefit from standard processes and validated measures.

METHODS: A writing group was formed among hepatologists, nurses, palliative care providers, pharmacists, and clinical trial experts focused on symptom management in patients with cirrhosis to define the key (1) components of trial design, (2) symptom targets, (3) measurement, and (4) outcomes for each target. From July 2022 to January 2023, panelists participated in an iterative process of developing and arriving at a consensus for each component. The goal was to provide consensus definitions that can be operationalized in …

Thirty-Day Outcomes Of Resolute Onyx Stent For Symptomatic Intracranial Stenosis: A Multicenter Propensity Score-Matched Comparison With Stenting Versus Aggressive Medical Management For Preventing Recurrent Stroke In Intracranial Stenosis Trial, Farhan Siddiq, Ravi S Nunna, Jonathan M Beall, Inamullah Khan, Musharaf Khan, Wondwossen G Tekle, Mohamad Ezzeldin, Omar Tanweer, Jan-Karl Burkhardt, Pascal M Jabbour, Stavropoula I Tjoumakaris, Nabeel A Herial, Adnan H Siddiqui, Ramesh Grandhi, Renee L Martin, Adnan I Qureshi, Ameer E Hassan

Faculty, Staff and Students Publications

BACKGROUND: Symptomatic intracranial atherosclerotic disease (sICAD) is estimated to cause 10% of strokes annually in the United States. However, treatment remains a challenge with several different stenting options studied in the past with unfavorable results.

OBJECTIVE: To report the 30-day stroke and/or death rate associated with intracranial stent placement for sICAD using Resolute Onyx Zotarolimus-Eluting Stent (RO-ZES) and provide a comparison with the results of Stenting Versus Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis (SAMMPRIS) trial.

METHODS: Prospectively maintained databases across 8 stroke centers were used to identify adult patients treated with RO-ZES for sICAD between January …

Preterm Birth Alters The Feeding-Induced Activation Of Akt Signaling In The Muscle Of Neonatal Piglets, Agus Suryawan, Marko Rudar, Jane K Naberhuis, Marta L Fiorotto, Teresa A Davis

Faculty, Staff and Students Publications

BACKGROUND: Postnatal lean mass accretion is commonly reduced in preterm infants. This study investigated mechanisms involved in the blunted feeding-induced activation of Akt in the skeletal muscle of preterm pigs that contributes to lower protein synthesis rates.

METHODS: On day 3 following cesarean section, preterm and term piglets were fasted or fed an enteral meal. Activation of Akt signaling pathways in skeletal muscle was determined.

RESULTS: Akt1 and Akt2, but not Akt3, phosphorylation were lower in the skeletal muscle of preterm than in term pigs (P < 0.05). Activation of Akt-positive regulators, PDK1 and mTORC2, but not FAK, were lower in preterm than in term (P < 0.05). The formation of Akt complexes with GAPDH and Hsp90 and the abundance of Ubl4A were lower in preterm than in term (P < 0.05). The abundance of Akt inhibitors, PHLPP and SHIP2, but not PTEN and IP6K1, were higher in preterm than in term pigs (P < 0.05). PP2A activation was inhibited by feeding in term but not in preterm pigs (P < 0.05).

CONCLUSIONS: Our results suggest that preterm birth impairs regulatory components involved in Akt activation, …

Covid-19 Vaccines And The Pandemic: Lessons Learnt For Other Neglected Diseases And Future Threats, Peter J Hotez, Sarah Gilbert, Melanie Saville, Lois Privor-Dumm, Salim Abdool-Karim, Didi Thompson, Jean-Louis Excler, Jerome H Kim

Faculty, Staff and Students Publications

Through the experiences gained by accelerating new vaccines for both Ebola virus infection and COVID-19 in a public health emergency, vaccine development has benefited from a 'multiple shots on goal' approach to new vaccine targets. This approach embraces simultaneous development of candidates with differing technologies, including, when feasible, vesicular stomatitis virus or adenovirus vectors, messenger RNA (mRNA), whole inactivated virus, nanoparticle and recombinant protein technologies, which led to multiple effective COVID-19 vaccines. The challenge of COVID-19 vaccine inequity, as COVID-19 spread globally, created a situation where cutting-edge mRNA technologies were preferentially supplied by multinational pharmaceutical companies to high-income countries while …

Novatest: Identifying Genes With Location-Dependent Noise Variance In Spatial Transcriptomics Data, Mohammed Abid Abrar, M Kaykobad, M Saifur Rahman, Md Abul Hassan Samee

Faculty, Staff and Students Publications

Motivation: Spatial transcriptomics (ST) can reveal the existence and extent of spatial variation of gene expression in complex tissues. Such analyses could help identify spatially localized processes underlying a tissue's function. Existing tools to detect spatially variable genes assume a constant noise variance across spatial locations. This assumption might miss important biological signals when the variance can change across locations.

Results: In this article, we propose NoVaTeST, a framework to identify genes with location-dependent noise variance in ST data. NoVaTeST models gene expression as a function of spatial location and allows the noise to vary spatially. NoVaTeST then statistically compares …

Longer Time To Recovery From Acute Kidney Injury Is Associated With Major Adverse Kidney Events In Patients With Cirrhosis, Kavish R Patidar, Mobasshir A Naved, Shaowli Kabir, Ananth Grama, Andrew S Allegretti, Giuseppe Cullaro, Sumeet K Asrani, Astin Worden, Archita P Desai, Marwan S Ghabril, Lauren D Nephew, Eric S Orman

Faculty, Staff and Students Publications

BACKGROUND: In patients with cirrhosis and acute kidney injury (AKI), longer time to AKI-recovery may increase the risk of subsequent major-adverse-kidney-events (MAKE).

AIMS: To examine the association between timing of AKI-recovery and risk of MAKE in patients with cirrhosis.

METHODS: Hospitalised patients with cirrhosis and AKI (n = 5937) in a nationwide database were assessed for time to AKI-recovery and followed for 180-days. Timing of AKI-recovery (return of serum creatinine7-days. Primary outcome was MAKE at 90-180-days. MAKE is an accepted clinical endpoint in AKI and defined as the composite outcome of ≥25% decline in estimated-glomerular-filtration-rate (eGFR) compared with baseline with …

Dual-Target Deep Brain Stimulation For Obsessive-Compulsive Disorder And Tourette Syndrome, Ricardo A Najera, Nicole Provenza, Huy Dang, Kalman A Katlowitz, Alyssa Hertz, Sandesh Reddy, Ben Shofty, Steven T Bellows, Eric A Storch, Wayne K Goodman, Sameer A Sheth

Faculty, Staff and Students Publications

No abstract provided.

Imaging Of Pediatric Calvarial And Skull Base Tumors: A Cog Diagnostic Imaging Committee/Spr Oncology Committee/Asnpr White Paper, Jarunee Intrapiromkul, Pattana Wangaryattawanich, Zoltan Patay, Thierry A G M Huisman, Jason N Wright, Jeremy Y Jones, Raghu Ramakrishnaiah, Rajan Patel, Adam E Goldman-Yassen, Stephen Kralik, Mark Mamlouk, Nilesh K Desai

Faculty, Staff and Students Publications

A standardized imaging protocol for pediatric oncology patients is essential for accurate and efficient imaging, while simultaneously promoting collaborative understanding of pathologies and radiologic assessment of treatment response. The objective of this article is to provide standardized pediatric imaging guidelines and parameters for evaluation of tumors of the pediatric orbit, calvarium, skull base, and temporal bone. This article was drafted based on current scientific literature as well as consensus opinions of imaging experts in collaboration with the Children's Oncology Group Diagnostic Imaging Committee, Society of Pediatric Radiology Oncology Committee, and American Society of Pediatric Neuroradiology.

Cost-Effective Microscopic Draping: Covid-19 Umbrella, Yusif Hajiyev, Ronald J Vilela

Faculty, Staff and Students Publications

We describe a cost-effective solution to limit aerosol transmission to the surgeon and other personnel in the operating room during otologic surgery.

Tumour Infiltrating Lymphocytes (Tils) And Immune Composition In Breast Cancer Patients From Kenya: Spatial Distributions And Associations With Risk Factors And Tumour Characteristics, Shahin Sayed, Hela Koka, Mustapha Abubakar, Kevin Gardner, Roberto Salgado, Zahir Moloo, Ambar Beatriz Caban-Ureña, Daniel Rosen, Patricia Castro, Mansoor Saleh, Asim Jamal Shaikh, Jasmit Shah, Jonine Figueroa, Francis Makokha, Hien Khanh Ha, Zhong Wang, Pumza Magangane, Richard Naidoo, Veronica Ngundo, Xiaohong Rose Yang, Dhirendra Govender

Faculty, Staff and Students Publications

Background: The immune landscape of breast cancer (BC) in patients from Sub Saharan Africa is understudied. Our aims were to describe the distribution of Tumour Infiltrating Lymphocytes (TILs) within the intratumoural stroma (sTILs) and the leading/invasive edge stroma (LE-TILs), and to evaluate TILs across BC subtypes with established risk factors and clinical characteristics in Kenyan women.

Methods: Visual quantification of sTILs and LE-TILs were performed on Haematoxylin and eosin -stained pathologically confirmed BC cases based on the International TIL working group guidelines. Tissue Microarrays were constructed and stained with immunohistochemistry (IHC) for CD3, CD4, CD8, CD68, CD20, and FOXP3. Linear …

Evolution Of Cisplatin Resistance Through Coordinated Metabolic Reprogramming Of The Cellular Reductive State, Wangie Yu, Yunyun Chen, Nagireddy Putluri, Abdullah Osman, Cristian Coarfa, Vasanta Putluri, Abu H M Kamal, Jennifer Kay Asmussen, Panagiotis Katsonis, Jeffrey N Myers, Stephen Y Lai, Wuhao Lu, Clifford C Stephan, Reid T Powell, Faye M Johnson, Heath D Skinner, Jawad Kazi, Kazi Mokim Ahmed, Linghao Hu, Addison Threet, Matthew D Meyer, James A Bankson, Tony Wang, Jack Davis, Kirby R Parker, Madison A Harris, Mokryun L Baek, Gloria V Echeverria, Xiaoli Qi, Jin Wang, Andy I Frederick, Alex J Walsh, Olivier Lichtarge, Mitchell J Frederick, Vlad C Sandulache

Faculty, Staff and Student Publications

BACKGROUND: Cisplatin (CDDP) is a mainstay treatment for advanced head and neck squamous cell carcinomas (HNSCC) despite a high frequency of innate and acquired resistance. We hypothesised that tumours acquire CDDP resistance through an enhanced reductive state dependent on metabolic rewiring.

METHODS: To validate this model and understand how an adaptive metabolic programme might be imprinted, we performed an integrated analysis of CDDP-resistant HNSCC clones from multiple genomic backgrounds by whole-exome sequencing, RNA-seq, mass spectrometry, steady state and flux metabolomics.

RESULTS: Inactivating KEAP1 mutations or reductions in KEAP1 RNA correlated with Nrf2 activation in CDDP-resistant cells, which functionally contributed to …

The Role Of High-Order Anharmonicity And Off-Diagonal Terms In Thermal Conductivity: A Case Study Of Multi-Phase Cspbbr3, Xiangdong Ding, Guimei Zhu, Yi Xia, Jie Ren, Jun Sun, Multiple Additional Authors

Mechanical and Materials Engineering Faculty Publications and Presentations

We investigate the influence of three- and four-phonon scattering, perturbative anharmonic phonon renormalization, and off-diagonal terms of coherent phonons on the thermal conductivity of CsPbBr3 phase change perovskite, by using advanced implementations and first-principles simulations. Our study spans a wide temperature range covering the entire structural spectrum. Notably, we demonstrate that the interactions between acoustic and optical phonons result in contrasting trends of phonon frequency shifts for the high-lying optical phonons in orthorhombic and cubic CsPbBr3 as temperature varies. Our findings highlight the significance of wavelike tunneling of coherent phonons in ultralow and glasslike thermal conductivity in halide perovskites.

Witnessing Academic Dishonesty And Student’S Satisfaction With Learning, Motivation For Studying And Evaluation Of Faculty, Dawoon Lee

Student Theses

Academic dishonesty has been a long-term problem in secondary and higher education. Previous studies reported that an average of two-thirds of students reported that they have engaged in academic dishonesty in high school or college. This study explored witnessing academic dishonesty and its influence on students' experiences in the learning environment. The hypothesis is that witnessing academic dishonesty will negatively impact the student’s satisfaction with learning, motivation for studying, and evaluation of faculty. In conducting the study, participants (N = 250) completed an online survey assessing their satisfaction with learning, motivation for studying, and evaluation of faculty. Participants also reported …

Open Fire: The Expansion Of 9mm Hollow Point Bullets In Relation To Tissue Thickness, Abigail Wilson

Student Theses

Bullets can be broadly differentiated into jacketed and unjacketed groups. Jacketed ammunition can be further broken down based on the bullet’s design, one of which is hollow points. This research examines a representative brand of jacketed hollow point bullets used in a common caliber cartridge, the 9mm Luger. A jacketed hollow point bullet is designed to expand when it encounters a viscous medium such as tissue. This experiment simulated tissue using ballistic gelatin and simulated skin using a chamois overlay. As a positive and negative control, a series of bullets were fired into a full-size block of gelatin to achieve …

Comparison Of Hydrolysis Efficiency And Performance Of Four Recombinant Β- Glucuronidase Enzymes For The Detection Of Opioids In Urine Samples By Lc-Ms/Ms, Christina Fernandez

Student Theses

The United States has been experiencing a nationwide public health crisis since introducing prescription opioids in the 1990s. A central problem with opioids is their highly addictive nature causing a dose-dependent respiratory depression leading to overdoses and deaths. Drug overdose deaths have risen in the past two decades, with opioids being the dominant driver of this epidemic. Given the circumstances, accurate and efficient confirmatory analysis of opioids in urine is essential to monitoring patients’ compliance and preventing drug diversion in clinical and forensic settings. The development of recombinant β-glucuronidases allows for the hydrolysis of glucuronidated opioids using a shorter incubation …

Early Experiences Of Parents Of Children Who Are Deaf Or Hard Of Hearing: Navigating Through Identification, Intervention, And Beyond, Gabriella Reynolds, Krystal L. Werfel, Morgan Vachio, Emily A. Lund

Journal of Early Hearing Detection and Intervention

Guidelines created by the Joint Committee on Infant Hearing ([JCIH], 2019) were designed to aid in the early identification of infant hearing loss. Despite these guidelines, a quarter of children who fail their initial screening are lost to the follow-up process and many more do not receive care in line with the 1-3-6 guidelines (Centers for Disease Control and Prevention [CDC], 2018; JCIH, 2019). To acquire more information about the experiences of families and identify specific barriers to timely diagnosis and intervention, interviews were conducted with 13 parents of children who are deaf or hard of hearing whose children were …

Improving South Dakota Parents’ Knowledge Of Congenital Cytomegalovirus, Hannah M. Williams, Jessica Messersmith, Jacynda Gellhaus

Journal of Early Hearing Detection and Intervention

Introduction: Congenital cytomegalovirus (cCMV) is the most common infectious condition present at birth and the leading non-genetic cause of sensorineural hearing loss in children. Despite CMV being common and preventable, knowledge of CMV remains low among individuals in the United States (Doutre et al., 2016). Sudden infant death syndrome (SIDS) is also common among infants in the United States, but unlike cCMV, several studies have researched which educational methods have been most effective for improving parents’ knowledge of safe sleep practices. The purpose of this study was to investigate whether educational methods shown to be most effective for improving parents’ …

Parent And Provider Perspectives On Early Intervention In Ohio: A Community Collaborative Approach, Jessa Reed, Ursula M. Findlen, Carrie Davenport, Cheryl Deconde Johnson, Maria Sentelik, Carrie Spangler, Wendy Steuerwald, Derek Houston

Journal of Early Hearing Detection and Intervention

The network of early intervention (EI) for families with children who are deaf or hard of hearing (D/HH) consists of multiple professionals that partner with parents. As part of a community collaborative initiative, diverse perspectives were gathered via online surveys as part of a state-wide needs assessment to evaluate the landscape of EI in Ohio. The qualitative and quantitative feedback were analyzed in light of the Joint Committee on Infant Hearing’s (2007) goals and the 2013 early intervention supplement to those goals. Care coordination and equitable access emerged as top priorities across all three stakeholder groups queried (audiologists, EI providers, …

Adverse Childhood Experiences In Mothers And Their Children With Hearing Loss, Elizabeth A. Rosenzweig

Journal of Early Hearing Detection and Intervention

This study examined the relationship between maternal and child ACEs in children with hearing loss ages 3-12. One hundred twenty-four mother-child dyads completed assessments of mother and child ACEs. Adverse cChildhood eExperiences (ACEs) were measured using the Center for Youth Wellness Adverse Childhood Experiences Questionnaire (CYW ACE-Q; Burke Harris & Renschler, 2015).

Both maternal and child participants in this study reported higher levels of ACE exposure than previously reported in studies of the general population. Maternal and child ACEs were significantly correlated. White/Caucasian mothers experienced significantly fewer ACEs than mothers of other races/ethnicities. Children living in adoptive, foster, or guardianship …