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To What Extent Do 3- To -6-Year-Olds Demonstrate Connection To Nature At A Montessori School In The Upper Midwest, Natasha Yates Jul 2023

To What Extent Do 3- To -6-Year-Olds Demonstrate Connection To Nature At A Montessori School In The Upper Midwest, Natasha Yates

School of Education and Leadership Student Capstone Theses and Dissertations

Yates, N. (2023). To What Extent Do 3- to -6-Year-Olds Demonstrate Connection to Nature at a Montessori School in the Upper Midwest.

Young children are born into a world today with a drastically changing environmental climate. When young people develop an emotional attachment and sense of identity with nature, they may be more likely to behave in less destructive ways towards the planet and possibly live with a sense of responsibility and respect for nature. This mixed method study aimed to measure to what extent 3- to 6-year-olds demonstrated environmental sensitivity, awareness, and preferences at a nature-based Montessori school in …


Er Translocon Inhibitor Ipomoeassin F Inhibits Triple-Negative Breast Cancer Growth Via Blocking Er Molecular Chaperones, Shishi Tao, Eun Ju Yang, Guanghui Zong, Pui Kei Mou, Guowen Ren, Liang Chen, Ho Jeong Kwon, Jianhong Zhou, Zhijian Hu, Arman Khosravi, Qingyang Zhang, Yuchun Du, Wei Q. Shi, Joong Sup Shim Jul 2023

Er Translocon Inhibitor Ipomoeassin F Inhibits Triple-Negative Breast Cancer Growth Via Blocking Er Molecular Chaperones, Shishi Tao, Eun Ju Yang, Guanghui Zong, Pui Kei Mou, Guowen Ren, Liang Chen, Ho Jeong Kwon, Jianhong Zhou, Zhijian Hu, Arman Khosravi, Qingyang Zhang, Yuchun Du, Wei Q. Shi, Joong Sup Shim

Biological Sciences Faculty Publications and Presentations

Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer where no effective therapy has been developed. Here, we report that the natural product ER translocon inhibitor ipomoeassin F is a selective inhibitor of TNBC cell growth. A proteomic analysis of TNBC cells revealed that ipomoeassin F significantly reduced the levels of ER molecular chaperones, including PDIA6 and PDIA4, and induced ER stress, unfolded protein response (UPR) and autophagy in TNBC cells. Mechanistically, ipomoeassin F, as an inhibitor of Sec61α-containing ER translocon, blocks ER translocation of PDIA6, inducing its proteasomal degradation. Silencing of PDIA6 or PDIA4 by RNA interferences …


Surveillance And The Future Of Work: Exploring Employees’ Attitudes Toward Monitoring In A Post-Covid Workplace, Jessica Vitak, Michael Zimmer Jul 2023

Surveillance And The Future Of Work: Exploring Employees’ Attitudes Toward Monitoring In A Post-Covid Workplace, Jessica Vitak, Michael Zimmer

Computer Science Faculty Research and Publications

The future of work increasingly focuses on the collection and analysis of worker data to monitor communication, ensure productivity, reduce security threats, and assist in decision-making. The COVID-19 pandemic increased employer reliance on these technologies; however, the blurring of home and work boundaries meant these monitoring tools might also surveil private spaces. To explore workers’ attitudes toward increased monitoring practices, we present findings from a factorial vignette survey of 645 U.S. adults who worked from home during the early months of the pandemic. Using the theory of privacy as contextual integrity to guide the survey design and analysis, we unpack …


Confidentiality Clauses In Settlement Agreements After The Consumer Review Fairness Act, Wayne Barnes Jul 2023

Confidentiality Clauses In Settlement Agreements After The Consumer Review Fairness Act, Wayne Barnes

Faculty Scholarship

Online commerce has skyrocketed in recent years, and shoppers are purchasing goods or services online in greater numbers every year. The COVID-19 pandemic has only hastened the trend. One significant aspect of online shopping is the presence of consumer reviews posted by prior purchasers of goods or services, describing their experience with the products, the services and/or the selling merchant. A vast majority of online shoppers say that they rely on these reviews to help inform their purchasing decisions. Positive reviews can be tremendously beneficial to a business’ profitability, whereas negative reviews can be equally detrimental. Users of the internet …


Lift Force Analysis For An Electrodynamic Wheel Maglev Vehicle, Colton W. Bruce, Jonathan Bird, Matthew K. Grubbs Jul 2023

Lift Force Analysis For An Electrodynamic Wheel Maglev Vehicle, Colton W. Bruce, Jonathan Bird, Matthew K. Grubbs

Electrical and Computer Engineering Faculty Publications and Presentations

This paper used an analytic based 3-D second order vector potential model to study the vertical dynamic force ripple and dynamic airgap height change when using a one pole-pair electrodynamic wheel (EDW) maglev vehicle. A one-pole pair EDW creates the lowest lift specific power; however transient finite element analysis (FEA) also shows that the one pole-pair EDW will create a large oscillating vertical force when maintaining a static airgap height. A dynamically coupled eddy current model was used to confirm that when the airgap length is allowed to change with time then an increase in vertical airgap creates a large …


Child And Adolescent Psychiatrists’ Use, Attitudes, And Understanding Of Genetic Testing And Pharmacogenetics In Clinical Practice, Takahiro Soda, Amanda R Merner, Brent J Small, Laura N Torgerson, Katrina Muñoz, Jehannine Austin, Eric A Storch, Stacey Pereira, Gabriel Lázaro-Muñoz Jul 2023

Child And Adolescent Psychiatrists’ Use, Attitudes, And Understanding Of Genetic Testing And Pharmacogenetics In Clinical Practice, Takahiro Soda, Amanda R Merner, Brent J Small, Laura N Torgerson, Katrina Muñoz, Jehannine Austin, Eric A Storch, Stacey Pereira, Gabriel Lázaro-Muñoz

Center for Medical Ethics and Health Policy Staff Publications

The purpose of this study was to report current practices and attitudes of child and adolescent psychiatrists (CAP) regarding diagnostic genetic and pharmacogenetic (PGx) testing. We surveyed 958 US-based practicing CAP. 54.9% of respondents indicated that they had ordered/referred for a genetic test in the past 12 months. 87% of respondents agreed that it is their role to discuss genetic information regarding psychiatric conditions with their patients; however, 45% rated their knowledge of genetic testing practice guidelines as poor/very poor. The most ordered test was PGx (32.2%), followed by chromosomal microarray (23.0%). 73.4% reported that PGx is at least slightly …


Peat Fires And The Unknown Risk Of Legacy Metal And Metalloid Pollution, Colin P.R. Mccarter, Gareth D. Clay, Sophie L. Wilkinson, Susan Page, Emma L. Shuttleworth, Scott J. Davidson, Muh Taufik, Gabriel Sigmund, James M. Waddington Jul 2023

Peat Fires And The Unknown Risk Of Legacy Metal And Metalloid Pollution, Colin P.R. Mccarter, Gareth D. Clay, Sophie L. Wilkinson, Susan Page, Emma L. Shuttleworth, Scott J. Davidson, Muh Taufik, Gabriel Sigmund, James M. Waddington

School of Geography, Earth and Environmental Sciences

Introduction. Peatlands have persisted for millennia, acting as globally-important sinks of atmospheric carbon dioxide (Yu 2012) and regionally-important role sinks of pollutants, such as lead, arsenic, or mercury (toxic metals and metalloids, TMMs) (Bindler 2006). The role peatlands play in atmospheric carbon sequestration often overshadows their role in storing pollutants despite, for example, peat mercury accumulation rates increasing 60–130× relative to pre-industrial rates (Bindler 2006). Peatlands sustain their carbon and TMM sink persistence through a suite of ecohydrological feedbacks and plant traits (Souter and Watmough 2016, McCarter et al 2020). However, the interaction of climate change, land-use change and wildfire …


Caveat Emptor: Scan Quality Of Elsevier's Digital Backfile Pdf Collection, Gregory M. Nelson, Paul K.J. Robbins, Dennis L. Eggett Jul 2023

Caveat Emptor: Scan Quality Of Elsevier's Digital Backfile Pdf Collection, Gregory M. Nelson, Paul K.J. Robbins, Dennis L. Eggett

Faculty Publications

Scans of journal articles originally published in print, otherwise known as digital journal backfiles, benefit library patrons by providing near instantaneous access to important older information and full-text searchability. Digital backfiles can serve as a reliable surrogate for their corresponding print journals which could be removed from the library, freeing up space for other patron services. Both benefits are realized when the scanned articles are of sufficient clarity to replace the print versions. Several studies have analyzed small and subject-narrow sections of Elsevier’s digital backfile. This article contains a scan-quality analysis from 1578 journals that contain nearly four million articles …


Accurate Covariance Estimation For Pose Data From Iterative Closest Point Algorithm, Rick H. Yuan, Clark N. Taylor, Scott L. Nykl Jul 2023

Accurate Covariance Estimation For Pose Data From Iterative Closest Point Algorithm, Rick H. Yuan, Clark N. Taylor, Scott L. Nykl

Faculty Publications

One of the fundamental problems of robotics and navigation is the estimation of the relative pose of an external object with respect to the observer. A common method for computing the relative pose is the iterative closest point (ICP) algorithm, where a reference point cloud of a known object is registered against a sensed point cloud to determine relative pose. To use this computed pose information in downstream processing algorithms, it is necessary to estimate the uncertainty of the ICP output, typically represented as a covariance matrix. In this paper, a novel method for estimating uncertainty from sensed data is …


Bishop Healy Committee E- Newsletter (Summer 2023), Bishop Healy Committee, College Of The Holy Cross Jul 2023

Bishop Healy Committee E- Newsletter (Summer 2023), Bishop Healy Committee, College Of The Holy Cross

Bishop Healy Committee Newsletter

This e-publication is the newsletter for Holy Cross ALANA alumni created by the Bishop Healy Committee of the Holy Cross Alumni Association (HCAA). Read student testimonials and alumni highlights, learn how to get involved through volunteering and mentorship, and stay up to date on campus news and events.

Featured articles include Commencement, Financial Literacy Workshop, LASO Noche Latina, upcoming events, a student highlight, engagement opportunities and HC community updates.


Submission To The United Nations Universal Periodic Review Of Saudi Arabia, Mwatana For Human Rights, Smith Family Human Rights Clinic Jul 2023

Submission To The United Nations Universal Periodic Review Of Saudi Arabia, Mwatana For Human Rights, Smith Family Human Rights Clinic

Human Rights Institute

Mwatana Organization for Human Rights (Mwatana) and the Columbia Law School Smith Family Human Rights Clinic (Clinic) jointly submit this report to inform the examination of Saudi Arabia during its Universal Periodic Review.


Carajás Corridor In Brazil: Could An Sea Have Reconciled Shared-Use Infrastructure And Environmental Protection?, Perrine Toledano, Martin Dietrich Brauch Jul 2023

Carajás Corridor In Brazil: Could An Sea Have Reconciled Shared-Use Infrastructure And Environmental Protection?, Perrine Toledano, Martin Dietrich Brauch

Columbia Center on Sustainable Investment

The 998km Carajás railway corridor connects the world’s largest iron ore mine, operated by private mining company Vale S.A. (Vale) in Brazil’s northern state of Pará (PA), to the company’s maritime terminal in São Luís, the capital of the northeastern state of Maranhão (MA). Carajás is one of the few integrated railway corridors financed by a mining company that, apart from transporting the iron ore that made the infrastructure investments viable, also transports general cargo and operates passenger services along the corridor. This corridor was born from the Brazilian government’s plans in the mid1950s that foresaw the iron ore reserves …


Antitrust And Sustainability: A Landscape Analysis, Columbia Center On Sustainable Investment, Sabin Center For Climate Change Law Jul 2023

Antitrust And Sustainability: A Landscape Analysis, Columbia Center On Sustainable Investment, Sabin Center For Climate Change Law

Columbia Center on Sustainable Investment

Competition policy and antitrust law are experiencing a global renaissance. New market realities such as digital market gatekeepers, the financialization of firms, highly concentrated markets, a rising labor movement, industrial policy, and trade wars, among others, are radically reshaping how this policy area is understood and applied.

Sustainability concerns have also been a driving force for reconstituting antitrust to meet twenty-first century challenges. It is now widely accepted that competition policy – both its aims and its enforcement – has wider societal impacts beyond competition, including effects on democracy, economic inequality, growth and innovation, racial and gender imbalances, privacy, geopolitical …


The Nciter Newsletter July 2023, National Counterterrorism Innovation, Technology, And Education Center Jul 2023

The Nciter Newsletter July 2023, National Counterterrorism Innovation, Technology, And Education Center

Newsletters

NCITE (National Counterterrorism Innovation, Technology, and Education) is the Department of Homeland Security's center of excellence for terrorism prevention and counterterrorism research. They are a federally funded academic consortium based in Omaha, Nebraska. Their newsletters covers the current news, activities, and updates of the center and the latest in counterterrorism research. NCITEr newsletter covers specifically center updates.


An Evolutionary Comparative Study Of Congenital Stationary Night Blindness-Associated Trpm1 Genetic Variants Of Uncertain Significance In Horses And Humans Utilizing Caenorhabditis Elegans, Gabrielle Davis Jul 2023

An Evolutionary Comparative Study Of Congenital Stationary Night Blindness-Associated Trpm1 Genetic Variants Of Uncertain Significance In Horses And Humans Utilizing Caenorhabditis Elegans, Gabrielle Davis

Theses

Congenital stationary night blindness (CSNB) is a heterogeneous collection of genetic diseases affecting the eyes and vision in horses and humans. Current research has implicated several genetic mutations impacting different genes involved in phototransduction and signal transmission, including TRPM1. In horses, genetic mutations in TRPM1 also result in a leopard spotting pattern or leopard complex. The goal of this study is to examine the potential impact of CSNB associated TRPM1 missense variants of uncertain significance (VUS). Previous research in Caenorhabditis elegans have revealed an orthologous TRPM1 gene known as gon-2 that allows for comparative studies. The evolutionary relationship of …


Enhancing And Securing Wireless Medical Technology For Diagnosis And Treatment Of Lower Urinary Tract Dysfunction, Farhath Zareen Jul 2023

Enhancing And Securing Wireless Medical Technology For Diagnosis And Treatment Of Lower Urinary Tract Dysfunction, Farhath Zareen

USF Tampa Graduate Theses and Dissertations

Lower urinary tract dysfunction (LUTD) is a debilitating medical condition that affects millions of individuals worldwide. Urodynamics is the current gold standard for diagnosing LUTD but uses non-physiologically fast, retrograde cystometric filling to obtain a brief snapshot of bladder function. Current state-of-the-art research in bladder monitoring includes ambulatory urodynamics using wireless implantable devices to evaluate bladder function during natural filling for long-term monitoring. However, there are various challenges and limitations to this multi-sensor approach. This research focuses on developing frameworks for automated event detection, data analysis, and optimization of long-term bladder recordingsto improve the diagnosis and treatment of LUTD. In …


Best Practices For Implementing Experimental Research Methods, Jennifer L. Stoner, Reto Felix, Ashley Stadler Blank Jul 2023

Best Practices For Implementing Experimental Research Methods, Jennifer L. Stoner, Reto Felix, Ashley Stadler Blank

Marketing Faculty Publications

Experimental research methods have a long history across a number of different disciplines—including consumer research. Although experiments are just one of many alternative research methods, experiments are notable because they are the best way to establish causation. This makes experiments a powerful tool when researchers need to show cause and effect relationships. In this article, we provide best practices for implementing experimental research methods in consumer studies. Specifically, we discuss several important topics researchers need to consider when designing experiments, including developing hypotheses, operationalizing the variables (manipulated or measured), deciding on the research design (between-subjects, within-subjects, or mixed), selecting the …


Policy - Vol. 47, Summer 2023 Jul 2023

Policy - Vol. 47, Summer 2023

Southern Illinois University Law Journal

No abstract provided.


Table Of Contents - Vol. 47, Summer 2023 Jul 2023

Table Of Contents - Vol. 47, Summer 2023

Southern Illinois University Law Journal

No abstract provided.


2022 Survey Of Illinois Law: Family Law, Stephanie L. Tang Jul 2023

2022 Survey Of Illinois Law: Family Law, Stephanie L. Tang

Southern Illinois University Law Journal

In 2022, there were significant changes to both family law legislation and case law. Relevant legislative changes include allowing litigants to seek attorney’s fees to retain a lawyer, allowing for temporary relocation, and clarifying when a change in circumstances is “contemplated” for purposes of modifying child support. Illinois courts also adjudicated cases across all areas of family law. These areas ranged from expanding on prior case precedent in areas like property division and allocation of parental responsibilities to establishing new precedent in others, including COVID-19 restrictions and allocation of frozen embryos.

This Article is a continuation of the 2017-2018 and …


Target Identification And Validation Of The Alpha7 Nicotinic Acetylcholine Receptor As A Potential Therapeutic Target In Retinal Disease, David M. Linn Jul 2023

Target Identification And Validation Of The Alpha7 Nicotinic Acetylcholine Receptor As A Potential Therapeutic Target In Retinal Disease, David M. Linn

Open Access Publishing Support Funded Articles

The role of acetylcholine (ACh) in visual processing in the mammalian retina has been the focus of research for many decades. Pioneering work on the localization of ACh discovered that the neurotransmitter is synthesized and stored in a distinct subpopulation of amacrine (starburst) cells. It has been shown that ACh release is regulated to a low resting “tonic” level, much like what is observed at the neuromuscular junction (NMJ). If there were a dysfunction in the tonic release of ACh, might post-synaptic changes render the targets of ACh [i.e., retinal ganglion cells (RGCs)] vulnerable to disease? During my time at …


Constitutive Als3 Expression In Candida Albicans Enhances Adhesion And Biofilm Formation Of Efg1, But Not Cph1 Mutant Strains, Nicholas C. Schena, Kassandra M. Baker, Anna A. Stark, Derek Thomas, Ian Cleary Jul 2023

Constitutive Als3 Expression In Candida Albicans Enhances Adhesion And Biofilm Formation Of Efg1, But Not Cph1 Mutant Strains, Nicholas C. Schena, Kassandra M. Baker, Anna A. Stark, Derek Thomas, Ian Cleary

Open Access Publishing Support Funded Articles

Adhesion to living and non-living surfaces is an important virulence trait of the fungal pathogen Candida albicans. Biofilm formation in this organism depends on the expression of a number of cell surface proteins including the hypha-specific protein Als3p. Loss of ALS3 impairs biofilm formation and decreases cell-cell adhesion. We wanted to test whether constitutively expressing ALS3 could compensate for defects in adhesion and biofilm formation observed in mutant strains that lack key transcriptional regulators of biofilm formation Efg1p and Cph1p. We found that ALS3 improved adhesion and biofilm formation in the efg1Δ and efg1Δ cph1Δ mutant …


Developing And Testing A Clinical Care Bundle Incorporating Caffeine Citrate To Manage Apnoea Of Prematurity In A Resource-Constrained Setting: A Mixed Methods Clinical Feasibility Study Protocol, Grace Irimu, Ferdinand Okwaro, Jesse Coleman, Mary Waiyego, Dorothy Chomba, Millicent Parsimei, Cynthia Shitote, Roseline Ochieng, Jasmit Shah, William Macharia Jul 2023

Developing And Testing A Clinical Care Bundle Incorporating Caffeine Citrate To Manage Apnoea Of Prematurity In A Resource-Constrained Setting: A Mixed Methods Clinical Feasibility Study Protocol, Grace Irimu, Ferdinand Okwaro, Jesse Coleman, Mary Waiyego, Dorothy Chomba, Millicent Parsimei, Cynthia Shitote, Roseline Ochieng, Jasmit Shah, William Macharia

Paediatrics and Child Health, East Africa

Background Apnoea of prematurity (AOP) is a common condition among preterm infants. Methylxanthines, such as cafeine and aminophylline/theophylline, can help prevent and treat AOP. Due to its physiological benefts and fewer side efects, cafeine citrate is recommended for the prevention and treatment of AOP. However, cafeine citrate is not available in most resource-constrained settings (RCS) due to its high cost. Challenges in RCS using caffeine citrate to prevent AOP include identifying eligible preterm infants where gestational age is not always known and the capability for continuous monitoring of vital signs to readily identify apnoea. We aim to develop an evidencebased …


Sherrilyn Denise Clayton Jul 2023

Sherrilyn Denise Clayton

African American Funeral Programs

Sherrilyn_Denise_Clayton.pdf - Funeral program for Sherrilyn Denise Clayton


Deacon Otis Lee Sampson Jul 2023

Deacon Otis Lee Sampson

African American Funeral Programs

Deacon_Otis_Lee_Sampson.pdf - Funeral program for Otis Lee Sampson


An Rrna Fragment In Extracellular Vesicles Secreted By Human Airway Epithelial Cells Increases The Fluoroquinolone Sensitivity Of P. Aeruginosa, Katja Koeppen, Thomas H Hampton, Roxanna Barnaby, Carolyn Roche, Scott A Gerber, Young Ah Goo, Byoung-Kyu Cho, Danielle M Vermilyea, Deborah A Hogan, Bruce A Stanton Jul 2023

An Rrna Fragment In Extracellular Vesicles Secreted By Human Airway Epithelial Cells Increases The Fluoroquinolone Sensitivity Of P. Aeruginosa, Katja Koeppen, Thomas H Hampton, Roxanna Barnaby, Carolyn Roche, Scott A Gerber, Young Ah Goo, Byoung-Kyu Cho, Danielle M Vermilyea, Deborah A Hogan, Bruce A Stanton

2020-Current year OA Pubs

Lung infections caused by antibiotic-resistant strains of


Delphi Consensus On Reporting Standards In Clinical Studies For Endovascular Treatment Of Acute Iliofemoral Venous Thrombosis And Chronic Iliofemoral Venous Obstruction, Suresh Vedantham, Peter Gloviczki, Teresa L. Carman, Sandra Zelman Lewis, Peter A. Schneider, Saher S. Sabri, Raghu Kolluri Jul 2023

Delphi Consensus On Reporting Standards In Clinical Studies For Endovascular Treatment Of Acute Iliofemoral Venous Thrombosis And Chronic Iliofemoral Venous Obstruction, Suresh Vedantham, Peter Gloviczki, Teresa L. Carman, Sandra Zelman Lewis, Peter A. Schneider, Saher S. Sabri, Raghu Kolluri

2020-Current year OA Pubs

Acute iliofemoral deep vein thrombosis and chronic iliofemoral venous obstruction cause substantial patient harm and are increasingly managed with endovascular venous interventions, including percutaneous mechanical thrombectomy and stent placement. However, studies of these treatment elements have not been designed and reported with sufficient rigor to support confident conclusions about their clinical utility. In this project, the Trustworthy consensus-based statement approach was utilized to develop, via a structured process, consensus-based statements to guide future investigators of venous interventions. Thirty statements were drafted to encompass major topics relevant to venous study description and design, safety outcome assessment, efficacy outcome assessment, and topics …


Helping Low-Income Smokers Quit: Findings From A Randomized Controlled Trial Comparing Specialized Quitline Services With And Without Social Needs Navigation, Matthew W Kreuter, Lauren M Grimes, Amy Mcqueen, Et Al. Jul 2023

Helping Low-Income Smokers Quit: Findings From A Randomized Controlled Trial Comparing Specialized Quitline Services With And Without Social Needs Navigation, Matthew W Kreuter, Lauren M Grimes, Amy Mcqueen, Et Al.

2020-Current year OA Pubs

BACKGROUND: Quitting smoking is especially challenging for low-income smokers due to high stress, high smoking prevalence around them, and limited support for quitting. This study aimed to determine whether any of three interventions designed specifically for low-income smokers would be more effective than standard tobacco quitline services: a specialized quitline, the specialized quitline with social needs navigation, or the standard quitline with social needs navigation.

METHODS: Using a randomized 2 × 2 factorial design, low-income daily cigarette smokers (n = 1944) in Missouri, USA who called a helpline seeking assistance with food, rent or other social needs were assigned to …


Nitric Oxide-Mediated S-Nitrosylation Of Iaa17 Protein In Intrinsically Disordered Region Represses Auxin Signaling, Hongwei Jing, Xiaolu Yang, Ryan J Emenecker, Jian Feng, Jian Zhang, Marcelo Rodrigues Alves De Figueiredo, Patarasuda Chaisupa, R Clay Wright, Alex S Holehouse, Lucia C Strader, Jianru Zuo Jul 2023

Nitric Oxide-Mediated S-Nitrosylation Of Iaa17 Protein In Intrinsically Disordered Region Represses Auxin Signaling, Hongwei Jing, Xiaolu Yang, Ryan J Emenecker, Jian Feng, Jian Zhang, Marcelo Rodrigues Alves De Figueiredo, Patarasuda Chaisupa, R Clay Wright, Alex S Holehouse, Lucia C Strader, Jianru Zuo

2020-Current year OA Pubs

The phytohormone auxin plays crucial roles in nearly every aspect of plant growth and development. Auxin signaling is activated through the phytohormone-induced proteasomal degradation of the Auxin/INDOLE-3-ACETIC ACID (Aux/IAA) family of transcriptional repressors. Notably, many auxin-modulated physiological processes are also regulated by nitric oxide (NO) that executes its biological effects predominantly through protein S-nitrosylation at specific cysteine residues. However, little is known about the molecular mechanisms in regulating the interactive NO and auxin networks. Here, we show that NO represses auxin signaling by inhibiting IAA17 protein degradation. NO induces the S-nitrosylation of Cys-70 located in the intrinsically disordered region of …


A Geriatric Approach To Percutaneous Coronary Interventions In Older Adults, Part Ii: A Jacc: Advances Expert Panel, Michael G Nanna, Michael W Rich, Et Al. Jul 2023

A Geriatric Approach To Percutaneous Coronary Interventions In Older Adults, Part Ii: A Jacc: Advances Expert Panel, Michael G Nanna, Michael W Rich, Et Al.

2020-Current year OA Pubs

We review a comprehensive risk assessment approach for percutaneous coronary interventions in older adults and highlight the relevance of geriatric syndromes within that broader perspective to optimize patient-centered outcomes in interventional cardiology practice. Reflecting the influence of geriatric principles in older adults undergoing percutaneous coronary interventions, we propose a "geriatric" heart team to incorporate the expertise of geriatric specialists in addition to the traditional heart team members, facilitate uptake of the geriatric risk assessment into the preprocedural risk assessment, and address ways to mitigate these geriatric risks. We also address goals of care in older adults, highlighting common priorities that …