Digital Commons Network^™

Identity, Structure, And Function Of The Mitochondrial Permeability Transition Pore: Controversies, Consensus, Recent Advances, And Future Directions, Paolo Bernardi, Christoph Gerle, Andrew P. Halestrap, Elizabeth A. Jonas, Jason Karch, Nelli Mnatsakanyan, Evgeny Pavlov, Shey-Shing Sheu, Alexander A. Soukas

Center for Translational Medicine Faculty Papers

The mitochondrial permeability transition (mPT) describes a Ca2+-dependent and cyclophilin D (CypD)-facilitated increase of inner mitochondrial membrane permeability that allows diffusion of molecules up to 1.5 kDa in size. It is mediated by a non-selective channel, the mitochondrial permeability transition pore (mPTP). Sustained mPTP opening causes mitochondrial swelling, which ruptures the outer mitochondrial membrane leading to subsequent apoptotic and necrotic cell death, and is implicated in a range of pathologies. However, transient mPTP opening at various sub-conductance states may contribute several physiological roles such as alterations in mitochondrial bioenergetics and rapid Ca2+ efflux. Since its discovery decades ago, intensive efforts …

Detecting Mental Distresses Using Social Behavior Analysis In The Context Of Covid-19: A Survey, Sahraoui Dhelim, Liming Chen, Sajal K. Das, Huansheng Ning, Chris Nugent, Gerard Leavey, Dirk Pesch, Eleanor Bantry-White, Devin Michael Burns

Computer Science Faculty Research & Creative Works

Online social media provides a channel for monitoring people's social behaviors from which to infer and detect their mental distresses. During the COVID-19 pandemic, online social networks were increasingly used to express opinions, views, and moods due to the restrictions on physical activities and in-person meetings, leading to a significant amount of diverse user-generated social media content. This offers a unique opportunity to examine how COVID-19 changed global behaviors regarding its ramifications on mental well-being. In this article, we surveyed the literature on social media analysis for the detection of mental distress, with a special emphasis on the studies published …

Synthesis Of Small Molecule Modulators Of Non-Traditional Drug Targets, Jamie Nunziata

USF Tampa Graduate Theses and Dissertations

This work details the effort toward structure-activity-relationship (SAR) studies and synthesis of the small molecule modulators of two non-traditional drug targets. The first part of this manuscript (chapters 1–2) will discuss the collaborative work and synthesis of an inhibitor of Slingshot Homology 1 (SSH1) with the potential therapeutic application toward Alzheimer’s Disease (AD) treatment. The second part (chapters 3–6) will discuss the synthetic efforts toward modulation of a protein target known as STING, or stimulator of interferon genes, with the therapeutic application toward autoimmune disease or anti-tumor activity.

AD is a progressive and degenerative illness that holds the title of …

Genomes To Fields 2022 Maize Genotype By Environment Prediction Competition, Dayane Cristina Lima, Jacob D. Washburn, José Ignacio Varela, Qiuyue Chen, Joseph L. Gage, Maria Cinta Romay, James Holland, David Ertl, Marco Lopez-Cruz, Fernando M. Aguate, Gustavo De Los Campos, Shawn Kaeppler, Timothy Beissinger, Martin Bohn, Edward Buckler, Jode Edwards, Sherry Flint-Garcia, Michael A. Gore, Candice N. Hirsch, Joseph E. Knoll, John Mckay, Richard Minyo, Seth C. Murray, Osler A. Ortez, James C. Schnable, Rajandeep S. Sekhon, Maninder P. Singh, Erin E. Sparks, Addie Thompson, Mitchell Tuinstra, Jason Wallace, Teclemariam Weldekidan, Wenwei Xu, Natalia De Leon

Department of Agronomy and Horticulture: Faculty Publications

Objectives The Genomes to Fields (G2F) 2022 Maize Genotype by Environment (GxE) Prediction Competition aimed to develop models for predicting grain yield for the 2022 Maize GxE project field trials, leveraging the datasets previously generated by this project and other publicly available data.

Data description This resource used data from the Maize GxE project within the G2F Initiative [1]. The dataset included phenotypic and genotypic data of the hybrids evaluated in 45 locations from 2014 to 2022. Also, soil, weather, environmental covariates data and metadata information for all environments (combination of year and location). Competitors also had access to ReadMe …

The Role Of Region And Religious Tradition In Predicting Individuals’ Expressions Of Faith In The Workplace, Jacqui Frost, Christopher P. Scheitle, Elaine Howard Ecklund, Denise Daniels

Purdue University Libraries Open Access Publishing Fund

While many variables might influence an individual’s willingness to express their faith in the workplace, the role of regional context has not been fully considered. The different geographical regions in the U.S. consist of unique demographics and cultures that could shape an individual’s expression of faith at work. Moreover, these regional effects might be moderated by an individual’s specific religious tradition. Using data from a survey of U.S. adults featuring oversamples of Jewish and Muslim individuals, we utilize two unique measures of religious expression—displaying/wearing religious items at work and talking about religion at work—to assess the roles of region and …

How Does Digital Technology Innovation Affect The Internationalization Performance Of Chinese Enterprises? The Moderating Effect Of Sustainability Readiness, Fei Li, Yang Zhao, Jaime Ortiz, Yan Chen

International Business and Entrepreneurship Faculty Publications

The existing literature highlights the role of digital technology innovation in driving the international performance of enterprises. However, it has largely overlooked the nonlinear relationships that emerge from their quest for contributing towards global sustainable development goals. Our study explores the nonlinear influence of digital technology innovation on firms’ international performance, further investigating how this relationship may be moderated by sustainability readiness, as measured through sustainable technological capabilities and sustainable certification standards. Using a double fixed effects model on a sample of 269 Chinese listed digital enterprises from 2012 to 2019, our findings reveal a U-shaped relationship between digital technology …

Understanding The Factors Associated With Us Dermatology Resident Trainees’ Diagnostic Confidence And Skill For Skin Of Color Pathology, Alissa Jeanfreau, Kaylin Beiter, Deborah Hilton

School of Medicine Faculty Publications

Background: Inequities in dermatologic health outcomes translate to worsened clinical outcomes for minority groups. For example, despite a lower incidence of skin cancer overall, African Americans are diagnosed at later stages with greater degrees of lymph node involvement. This has been shown to lead to disproportionate mortality when compared to lighter skinned individuals. Medical education materials contain a significantly lower percentage of skin of color (SOC) images than of lighter skin and research has indicated lower diagnostic accuracy of dermatologic conditions in darker skin by U.S. medical students. The objective of this study was to explore U.S. resident dermatologists’ ability …

Julie Kinsey, Petitioner/Appellee V. Glen D. Kinsey, Respondent/Appellant : Brief Of Appellee, Utah Court Of Appeals

Utah Court of Appeals Briefs (2020 –)

Appeal from a final Order entered on February 17, 2023, by the Third Judicial District Court in and for Salt Lake County, State of Utah The Honorable Dianna Gibson, District Court Judge, presiding

K. Bradley Carr, No. 14428 CARR & WOODALL Attorney for Appellant

Cory R. Wall, No. 4937 WALL & WALL, PС Attorney for Appellee

State Of Utah, Plaintiff/Appellee V. Lisa Yvonne Oreilly, Defendant/Appellant : Brief Of Appellant, Utah Court Of Appeals

Utah Court of Appeals Briefs (2020 –)

Appeal from the District Court for the Sixth Judicial District Court for Garfield County Judge Mandy Larsen

Jerry Jaeger, Attorney for Appellee

Nicolas C. Wilde, Trevor J. Lee, Attorneys for Appellant

Exploring The Digital Divide In Educational Technology Across Illinois School Districts: A Focus On Business Education In Urban, Suburban, And Rural Schools, Zahra Syedah Kazmi

Theses and Dissertations

This research study examines the extent of the digital divide in educational technologies among K-12 Illinois public schools, with a specific focus on business education. The study investigates the disparities in access and usage of educational technologies across urban, suburban, and rural schools in Illinois, aiming to identify the challenges and opportunities for promoting equitable access to technology in education. The research findings indicate significant differences in access and usage of educational technologies among the different types of schools. While all schools experience the digital divide to some extent, rural schools face more pronounced challenges in accessing and utilizing educational …

Efficient Synchronous Byzantine Consensus, Nibesh Shrestha

Theses

With the emergence of decentralized technologies such as Blockchains, Byzantine consensus protocols have become a fundamental building block as they provide a consistent service despite some malicious and arbitrary process failures. While the Byzantine consensus problem has been extensively studied for over four decades under various settings, many challenges and open problems still exist. Improving the communication complexity and the latency or round complexity are the two key challenges in the design of efficient and scalable solutions for the Byzantine consensus problem. This thesis focuses on improving the communication complexity and the round complexity of the synchronous Byzantine consensus problem …

Large Dry Metal Electrodes For Physiological Monitoring, Krittika Goyal

Theses

Cardiovascular disease is the leading cause of death in the United States. In-home physiological monitoring systems have a potential to track daily changes in cardiovascular health and to provide health care professionals data about the recovery or deterioration of their patient’s cardiac health. Various in-home monitoring systems have been designed to capture physiological signals from both standard (chest, wrist) and non-standard (palms, buttocks) locations. Unfortunately, most in-home monitoring systems provide poor signal quality due to the use of dry electrodes. Dry electrodes have an unstable electrochemical interface that results in high and variable contact impedance and poor signal quality. The …

Columbia Leasing L.P. V. Williams

All Decisions

No abstract provided.

Ancestry-Driven Metabolite Variation Provides Insights Into Disease States In Admixed Populations, Kaylia M Reynolds, Andrea R V R Horimoto, Bridget M Lin, Ying Zhang, Nuzulul Kurniansyah, Bing Yu, Eric Boerwinkle, Qibin Qi, Robert Kaplan, Martha Daviglus, Lifang Hou, Laura Y Zhou, Jianwen Cai, Saame Raza Shaikh, Tamar Sofer, Sharon R Browning, Nora Franceschini

Faculty, Staff and Student Publications

BACKGROUND: Metabolic pathways are related to physiological functions and disease states and are influenced by genetic variation and environmental factors. Hispanics/Latino individuals have ancestry-derived genomic regions (local ancestry) from their recent admixture that have been less characterized for associations with metabolite abundance and disease risk.

METHODS: We performed admixture mapping of 640 circulating metabolites in 3887 Hispanic/Latino individuals from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Metabolites were quantified in fasting serum through non-targeted mass spectrometry (MS) analysis using ultra-performance liquid chromatography-MS/MS. Replication was performed in 1856 nonoverlapping HCHS/SOL participants with metabolomic data.

RESULTS: By leveraging local ancestry, this …

The Effect Of Therapeutic Alliance Quality On Relationship Quality, With Latino Ethnicity As A Moderator: An Exploratory Study, Ivana Elisa Borba Gomez

Theses and Dissertations

A strong therapeutic alliance is consistently related to successful outcomes in couple therapy. However, most of the research done on therapeutic alliance has been done among non-Latino White individuals and couples, failing to account for other ethnic minorities like Latinos. Latinos tend to share certain commonalities as opposed to non-Latino clients that may alter the relationship between alliance quality and relationship quality. This exploratory study was designed to understand whether Latino clients have higher initial levels of alliance and a stronger alliance-outcome relationship in couple therapy when compared to non-Latino White couples. The sample consisted of 567 couples seeking therapy …

State Of Utah, Plaintiff/Appellee V. Lisa Yvonne Oreilly, Defendant/Appellant : Brief Of Appellant, Utah Court Of Appeals

Utah Court of Appeals Briefs (2020 –)

Appeal from the District Court for the Sixth Judicial District Court for Garfield County Judge Mandy Larsen

Jerry Jaeger Special Garfield County Attorney Attorney for Appellee

Nicolas C. Wilde Law Office of Nicolas C. Wilde, LLC Trevor J. Lee Hoggan Lee Hutchinson Attorneys for Appellant

The Lived Experiences Of Expert Nurse Clinicians Transition To Novice Nurse Educators: A Phenomenological Study, Sabrina L. Colbert

Dissertations

The literature is replete with information regarding the nationwide shortage of nursing faculty occurring in academia and practice. Due to the lack of available nursing faculty, masters-prepared nurses are being recruited into academia from clinical practice: expert clinicians with limited preparation in educational pedagogy. This descriptive phenomenological study explored the lived experiences of participants who transitioned from expert nurse clinicians to novice nurse educators in academia. The theoretical framework was Benner's novice to expert theory to explain and interpret the phenomenon as consciously experienced by novice nurse educators.

Anti-Mir-93-5p Therapy Prolongs Sepsis Survival By Restoring The Peripheral Immune Response, Mihnea P Dragomir, Enrique Fuentes-Mattei, Melanie Winkle, Keishi Okubo, Recep Bayraktar, Erik Knutsen, Aiham Qdaisat, Meng Chen, Yongfeng Li, Masayoshi Shimizu, Lan Pang, Kevin Liu, Xiuping Liu, Simone Anfossi, Huanyu Zhang, Ines Koch, Anh M Tran, Swati Mohapatra, Anh Ton, Mecit Kaplan, Matthew W Anderson, Spencer J Rothfuss, Robert Silasi, Ravi S Keshari, Manuela Ferracin, Cristina Ivan, Cristian Rodriguez-Aguayo, Gabriel Lopez-Berestein, Constantin Georgescu, Pinaki P Banerjee, Rafet Basar, Ziyi Li, David Horst, Catalin Vasilescu, Maria Teresa S Bertilaccio, Katayoun Rezvani, Florea Lupu, Sai-Ching Yeung, George A Calin

Faculty, Staff and Student Publications

Sepsis remains a leading cause of death for humans and currently has no pathogenesis-specific therapy. Hampered progress is partly due to a lack of insight into deep mechanistic processes. In the past decade, deciphering the functions of small noncoding miRNAs in sepsis pathogenesis became a dynamic research topic. To screen for new miRNA targets for sepsis therapeutics, we used samples for miRNA array analysis of PBMCs from patients with sepsis and control individuals, blood samples from 2 cohorts of patients with sepsis, and multiple animal models: mouse cecum ligation puncture-induced (CLP-induced) sepsis, mouse viral miRNA challenge, and baboon Gram+ and …

Assessing The Impacts Of Increasing The Availability Of Non-Automobile Modes Of Transportation On Carbon Emissions And Accessibility In Worcester, William Schechter

Sustainability and Social Justice

Over-reliance on cars in Worcester, Massachusetts represents a significant barrier to the introduction of accessible and ecologically sound modes of transportation. Through increases in frequency, accessibility, and service area, bus transportation in Worcester can offer a viable alternative to personal vehicle usage. In conjunction with the changes to buses, improvements to infrastructure for non-motorist transportation modes such as cycling, walking and assistive equipment will further reduce reliance on personal motor vehicles. Additional policies discouraging the use of motor vehicles is also suggested, with limited traffic zones and vehicle weight restrictions being implemented. With the developments and policy outlined within this …

“In A Religious Celebration”? The Religious Defense Of Lgbt Rights In U.S. Federal Courts, Kelsy Burke, Emily Kazyak, Maia Behrendt

Department of Sociology: Faculty Publications

This article advances scholarship on the relationship between sexuality, religion, and the law within the United States by analyzing case summaries and court opinions of the federal appellate cases decided between 1990 and 2020 that involve a religion-based claim being used to advance or defend gay and lesbian rights. Contrary to dominant public narratives that position religion uniformly in opposition to progressive sexual values, these cases show how Americans’ religious beliefs and practices include diverse sexual identities. We find that the courts’ reactions to such cases, however, illustrate the tension within legal discourse and hesitancy for the courts to equate …

College Of Education News, Georgia Southern University

College of Education: News & Publications (2003-2023)

• Students deployed as literacy tutors
• Summer training for Hodge Elementary leadership
• Doctoral students awarded memorial scholarship
• Gulfstream expands grad assistantship

Synthesis Of Tools For The Investigation And Treatment Of Infectious Diseases, Grant Lawrence

USF Tampa Graduate Theses and Dissertations

Modern medicine’s ability to treat a wide array of diseases is due mainly to the development of small-molecule drug discovery. Thousands of years of traditional medicines have been dwarfed in less than a hundred years. In addition, drug discovery has becoming a more consistent process with the introduction of the clinical trials process as well.Plasmodium is a genus of tropical parasites that have the potential to wreak havoc on billions of people globally. Current methods of drug discovery aimed at defeating these parasites require expensive assays that use radioactive material. By using an alkyne-labeled agent instead of a tritium-labeled agent, …

Omitting The Systematic Prostate Biopsy: Ready For Prime Time?, Joon Yau Leong, Kerith R. Wang, Thenappan Chandrasekar

Department of Urology Faculty Papers

No abstract provided.

Comparative Outcomes Of Lung Volume Reduction Surgery And Lung Transplantation: A Systematic Review And Meta-Analysis, Danial Ahmad, Brandon E. Ferrell, Abhiraj Saxena, Diana C. Jiminez, Thomas J. O/Malley, Marco Dispagna, Vakhtang Tchantchaleishvili

Department of Surgery Faculty Papers

Background: Lung volume reduction (LVR) and lung transplantation (LTx) have been used in different populations of chronic obstructive pulmonary disease (COPD) patients. To date, comparative study of LVR and LTx has not been performed. We sought to address this gap by pooling the existing evidence in the literature.

Methods: An electronic search was performed to identify all prospective studies on LVR and LTx published since 2000. Baseline characteristics, perioperative variables, and clinical outcomes were extracted and pooled for meta-analysis.

Results: The analysis included 65 prospective studies comprising 3,671 patients [LTx: 15 studies (n=1,445), LVR: 50 studies (n=2,226)]. Mean age was …

Temporal And Spatial Profiling Of Priority Soil Pollutants Using Filter Cone Spray Ionization-Mass Spectrometry ( Fcsi-Ms ), Rosemary Addo

Theses and Dissertations

Long-term monitoring (LTM) of environmental matrices can assist in detecting the onset or changes in chemical contaminant plumes and evaluating subsequent remediation efforts, but bears extreme cost, with significant funds going towards shipping costs of field-collected samples for off-site processing via hyphenated MS methods. To this end, portable technologies that offer both direct sampling capability and high throughput operation are appealing. We report and characterize the use of filter cone spray ionization-mass spectrometry (FCSI-MS) towards the temporal and spatial profiling of pollutants from unprepared soil sample and demonstrate its utility on portable and commercial MS systems alike. MS systems employed …

Twitter Trends During The 82nd Session Of The Nevada Legislature, 2023, Annie Vong, Zachary Billot, Mary Blankenship, Caitlin J. Saladino, William E. Brown Jr.

Elections & Governance

This fact sheet examines Twitter trends during the 82nd Session of the Nevada Legislature (2023). Data are comprised of tweets posted on Twitter by users located in Nevada addressing the most discussed topics during the session.

Science Communication Training Imparts Confidence And Influences Public Engagement Activity, Christina M. Swords, Jerlym S. Porter, Amy J. Hawkins, Edwin Li, Melissa Rowland-Goldsmith, Matthew D. Koci, John F. Tansey, Nicole C. Woitowich

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

The impacts of science are felt across all socio-ecological levels, ranging from the individual to societal. In order to adapt or respond to scientific discoveries, novel technologies, or biomedical or environmental challenges, a fundamental understanding of science is necessary. However, antiscientific rhetoric, mistrust in science, and the dissemination of misinformation hinder the promotion of science as a necessary and beneficial component of our world. Scientists can promote scientific literacy by establishing dialogues with nonexperts, but they may find a lack of formal training as a barrier to public engagement. To address this, the American Society for Biochemistry and Molecular Biology …

Petition

Catholic Dioceses in Bankruptcy

No abstract provided.

Phylogeographic History Of The Leaf-Eared Mouse, Phyllotis Xanthopygus Complex, Tabitha R. Mcfarland

Biology ETDs

Museum collections provide essential biodiversity sampling needed to understand the species limits, phylogeny, and biogeographic history of mammals, all key features of the foundation for comparative analyses in ecology and evolution. We add to this framework a diverse assemblage of species of leaf-eared mice (genus Phyllotis) in South America and then focus on the Phyllotis xanthopygus complex by combining available mitochondrial sequence (cytochrome b; cytb) data (351 GenBank samples) with 52 newly sequenced museum samples from the northern extent of this complex’s range (51 from Bolivia and 1 from northern Chile) to reconstruct evolutionary relationships using maximum …

The Effect Of Sodium Bicarbonate On Acute Kidney Injury Markers During Physical Work In The Heat, Abdulaziz Abdulrahman A. Masoud, Fabiano Amorim, Christine Mermier, Michael Deyhle, Zidong Li

Health, Exercise, and Sports Sciences ETDs

Sodium bicarbonate supplementation (NaHCO₃) before physical work in the heat may reduce the risk of developing acute kidney injury (AKI). Purpose: To determine the effects of NaHCO₃ supplementation before a prolonged bout of physical work in the heat on AKI markers and kidney function. Method: A randomized, cross-over, double blinded design was conducted on 8 participants (3 females) who consumed NaHCO₃ (0.2 g/kg body weight) or placebo (CON) before prolonged (120 minutes) moderate intensity (~65% of maximal heart rate) physical work in the heat [40℃ and 23% relative humidity (RH)]. Blood and urine samples were collected …