Digital Commons Network^™

The Impact Framework And Implementation For Accessible In Silico Clinical Phenotyping In The Digital Era, Kurt Miller, Liwei Wang, Kirk E Roberts, Steven D Bedrick, William R Hersh, Hongfang Liu

Faculty, Staff and Student Publications

Clinical phenotyping is often a foundational requirement for obtaining datasets necessary for the development of digital health applications. Traditionally done via manual abstraction, this task is often a bottleneck in development due to time and cost requirements, therefore raising significant interest in accomplishing this task via in-silico means. Nevertheless, current in-silico phenotyping development tends to be focused on a single phenotyping task resulting in a dearth of reusable tools supporting cross-task generalizable in-silico phenotyping. In addition, in-silico phenotyping remains largely inaccessible for a substantial portion of potentially interested users. Here, we highlight the barriers to the usage of in-silico phenotyping …

Non-Invasive Arterial Blood Pressure Measurement And Spo2 Estimation Using Ppg Signal: A Deep Learning Framework, Dulin Wang, Wentao Li, Sean I Savitz, Xiaoqian Jiang, Shayan Shams

Faculty, Staff and Student Publications

BACKGROUND: Monitoring blood pressure and peripheral capillary oxygen saturation plays a crucial role in healthcare management for patients with chronic diseases, especially hypertension and vascular disease. However, current blood pressure measurement methods have intrinsic limitations; for instance, arterial blood pressure is measured by inserting a catheter in the artery causing discomfort and infection.

METHOD: Photoplethysmogram (PPG) signals can be collected via non-invasive devices, and therefore have stimulated researchers' interest in exploring blood pressure estimation using machine learning and PPG signals as a non-invasive alternative. In this paper, we propose a Transformer-based deep learning architecture that utilizes PPG signals to conduct …

Sexuality, Religiousness, And Mental Health Among Sexual Minority Latter-Day Saints In Other-Gender Relationships, G. Tyler Lefevor

Psychology Faculty Publications

To guide therapists working with sexual minority individuals considering entering in an other-gender relationship, we present data from 82 sexual minority, current Latter-day Saints in other-gender relationships, 155 sexual minority, former Latter-day Saints in same-gender relationships, and 123 cisgender/heterosexual, current Latter-day Saints in other-gender relationships. Results suggest that relative to cisgender/heterosexual individuals, sexual minority individuals (both in same- and other-gender relationships), report being less happy in their relationship, viewing porn and masturbating more often, and experiencing greater religious struggles. Sexual minority individuals in both same- and other-gender relationships reported happiness in their relationships and lives; however, the two groups differed …

China Maritime Report No. 29: Plan Mine Countermeasures: Platforms, Training, And Civil-Military Integration, Brian Waidelich, George Pollitt

CMSI China Maritime Reports

The People’s Liberation Army Navy (PLAN) has made incremental progress in its mine countermeasures (MCM) program in recent years. The PLAN’s current inventory of about 60 MCM ships and craft includes classes of minehunters and minesweepers mostly commissioned in the past decade as well as unmanned surface vessels (USVs) and remotely operated vehicles with demonstrated explosive neutralization capability. Despite the addition of these advanced MCM platforms and equipment, experts affiliated with the PLAN and China’s mine warfare development laboratory have serious reservations about the PLAN’s current ability to respond to the full range of likely threats posed by naval mines …

A Review Of Black Psychology Courses Across United States’ Colleges And Universities: An Update Of Hicks And Ridley (1979), Kerry Lynn Jones

Electronic Theses and Dissertations Archive

More than 40 years ago, Hicks and Ridley (1979) asserted the need for Black Studies in psychology across American colleges and universities. Their study is one of few, if not the only, that has examined the frequency and types of course offerings in Black Psychology. Thus, the purpose of this study is to evaluate the current state of Black Psychology course offerings and course types in United States’ colleges and universities. Participants were recruited from 121 United States’ four-year colleges and universities, which included 63 Historically Black Colleges and Universities (HBCUs) and 58 U.S. News 2023 Best Psychology schools. Participants …

Bighorn Sheep Respiratory Disease Surveillance Via Animal Behavior And Community Science, Sidney Brenkus

Electronic Theses and Dissertations Archive

As humans continue to alter the environment, infectious diseases have become increasingly important challenges to wildlife populations and surveillance can play an important role in the management of such diseases. However, physiological surveillance is logistically and economically challenging, hampering our ability to detect disease incidence and spread. My work aimed to circumvent some of these challenges using an iconic species of North American wildlife as a model system: bighorn sheep (Ovis canadensis). For decades, Bighorn Sheep Respiratory Disease (BHSRD) has reduced lamb survival, decreased population growth and stability, and even led to local extinctions. As such, monitoring this disease is …

Can Provider Bias Impact Patient Treatment Outcomes: A Qualitative Analysis, Tracey Davis Moore

Electronic Theses and Dissertations Archive

Research has shown that social determinants of health, healthcare disparities, and historical trauma have contributed to inferior health outcomes for minority groups in the United States compared to their white counterparts. This qualitative research explores how healthcare providers perceive their own unconscious or implicit biases, which could potentially impact patient treatment outcomes. Bias is defined as a lack of objectivity combined with a preference for a particular person, group, or item. Data were collected using a multidisciplinary sample of healthcare treatment providers who participated in semi-structured individual interviews with the researcher. Twenty-six participants were interviewed with the same questions and …

Exploring Burnout Amongst Mental Health Counselors Within Three Workplace Settings, Courtney Loveless

Electronic Theses and Dissertations Archive

Throughout recent years, the work setting of many mental health counselors has changed from the in-person work setting to working from home and hybrid (i.e., a combination of working in-person and working from home). However, limited research has been conducted to explore burnout among these three work settings. Burnout is a condition which develops due to chronic feelings of stress and can cause negative repercussions on one’s health and overall wellbeing. Burnout is related to one’s experience within the work-setting and is characterized by extreme exhaustion, the inability to regulate emotions and cognitions, and mental distancing. Research regarding burnout has …

Socialist Ideals Of The New Woman In Weimar Germany, Hafife Montgomery

Electronic Theses and Dissertations Archive

Montgomery, Hafife. Ph.D. The University of Memphis. August, 2023. Socialist Ideals of the New Woman in Weimar Germany. Major Professor: Daniel L. Unowsky, Ph.D. This dissertation investigates the women’s magazines published by the Social Democratic Party of Germany (Sozialdemokratische Partei Deutschlands, SPD: Die Genossin, 1924-1933, and Frauenwelt, 1924-1933), the Communist Party of Germany (Kommunistische Partei Deutschlands, KPD: Die Kommunistin, 1919-1926), and its media mogul Willi Münzenberg (Der Weg der Frau, 1931-1933), as well as the SPD affiliated Arbeiterwohlfahrt (Workers’ Welfare: Arbeiterwohlfahrt, 1926-1933) during the Weimar Republic (1918-1933). I examine the organizations’ reasons for publishing women’s periodicals during a time of …

A Bird’S-Eye View Of Colonias Hosting Forgotten Americans And Their Community Resilience In The Rio Grande Valley, Dean Kyne

Sociology Faculty Publications

Colonia communities, which host forgotten Americans, lack essential services such as portable water, adequate wastewater and solid waste disposal, adequate drainage, and adequate paved roads. The aim of this study is to investigate five key aspects of the colonias in the Rio Grande Valley (RGV), which include the total count of colonias in the valley, their susceptibility to public health hazards, flooding occurrences, the transformations that have occurred over the past two decades, and community resilience. This research utilizes two datasets, namely the Colonia Database from the Texas Secretary of State and the community resiliency estimates from the Census Bureau. …

Ortho-Fluoro Effect On The C–C Bond Activation Of Benzonitrile Using Zerovalent Nickel, Sébastien Lachaize, Dominique C. Gallegos, Juliana J. Antonio, Abdurrahman C. Atesin, Tülay A. Ateşin, William D. Jones

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Chemistry)

The effect of fluoro substitution on the C–C bond activation of aromatic nitriles has been studied by reacting a variety of fluorinated benzonitriles with the nickel(0) fragment [Ni(dippe)] and by locating the reaction intermediates and transition-state structures on the potential energy surface by using density functional theory calculations with the [Ni(dmpe)] fragment (dippe = 1,2-bis(diisopropylphosphino)ethane, dmpe = 1,2-bis(dimethylphosphino)ethane). As in the previous reports, the reaction of fluorinated benzonitriles with the [Ni(dippe)] fragment initially formed an η2-nitrile complex, which then converted to the C–CN bond activation product. Thermodynamic parameters for the equilibrium between these complexes have been determined experimentally in both …

20230721_Open Educational Resources- What Are They And How Can I Use Them, Robyn Gleasner

HSLIC Blog Post

No abstract provided.

Returning To Northern New Mexico. A Study Of The Nuevomexicano Lexicon., Guevara Del Angel

Spanish and Portuguese ETDs

Spanish in New Mexico prior to the 1900s was the predominant language of the region that began to be displaced with the growth of the English-speaking population during the 20th century. In this dissertation I refer to the Spanish language variety that has had the longest historical presence in northern New Mexico and Southern Colorado as Traditional New Mexican Spanish (TNMS, as per Bills & Vigil, 2008). This study aims to document aspects of maintenance and change regarding TNMS. The traditional heritage variety of New Mexican Spanish is changing in many ways, evolving from what has been documented in the …

State Of Urbanization In Nepal: The Official Definition And Reality, Keshav Bhattarai, Ambika P. Adhikari, Shiva Gautam

Himalayan Research Papers Archive

Nepali government’s official delineation of several human settlements as new urban areas has been questionable because many important criteria such as urban infrastructure and services, open space, population density and economic viability are not thoroughly analyzed while defining what is urban. Many settlements in Nepal officially defined as urban, often driven by political considerations, are operating in the rural framework forming ruralopolises. This paper analyzes various criteria needed for defining urbanization that are internationally accepted to assess Nepal’s official definition of urban settlements. Urban areas have been expanding in Nepal at the cost of agricultural, forest, and shrubland land uses. …

The Effect Of Mandatory Triage Questions On Triage Processes: A Qualitative Exploratory Study, Paul Clark Rn, Phd, Ma, Faen

Faculty and Staff Scholarship

Objective: The study purpose was to obtain an understanding of both the types of questions mandated for the triage encounter in emergency departments across the US, and how emergency nurses (EN) perceive the relevance of these questions to the triage process. Methods: a qualitative descriptive exploratory study using focus group data was used. Data were collected at an in-person emergency nursing conference held in September 2022. Data were analyzed using Mayring’s 8-step process. Results: Participants (n=35) voiced concerns about a lack of expertise at all points in the triage process. The overarching problem is reported as data required by regulatory …

Slow-Wave Modulation Analysis During States Of Unconsciousness Using The Novel Tau-Modulation Method, Tao Xie, Zehan Wu, Thomas J Foutz, Xinjun Sheng, Xiangyang Zhu, Eric C Leuthardt, Jon T Willie, Liang Chen, Peter Brunner

2020-Current year OA Pubs

No abstract provided.

Optimizing Large-Capacity Key-Value Systems For Efficient Data Management, Kefei Wang

LSU Doctoral Dissertations

In today's Internet services, key-value system is playing a crucial and indispensable role, and has attracted extensive research in both academia and industry. During the past years, we have witnessed an unprecedented quick development of both memory-based and flash-based key-value systems. With the rapid evolution of memory and storage technologies, we are seeing both challenges and research opportunities.

In this dissertation, we focus on understanding and optimizing the efficiency of large-capacity, high-speed key-value systems from the perspective of both software and hardware to meet the ever-growing performance expectations. We first propose a multi-tier mapping structure, called Cascade Mapping, exploring the …

Kappa Opioid Receptor Activation Increases Thermogenic Energy Expenditure Which Drives Increased Feeding, Aaron L Cone, Kenny K Wu, Alexxai V Kravitz, Aaron J Norris

2020-Current year OA Pubs

Opioid receptors, including the kappa opioid receptor (KOR), exert control over thermoregulation and feeding behavior. Notably, activation of KOR stimulates food intake, leading to postulation that KOR signaling plays a central role in managing energy intake. KOR has also been proposed as a target for treating obesity. Herein, we report studies examining how roles for KOR signaling in regulating thermogenesis, feeding, and energy balance may be interrelated using pharmacological interventions, genetic tools, quantitative thermal imaging, and metabolic profiling. Our findings demonstrate that activation of KOR in the central nervous system causes increased energy expenditure via brown adipose tissue activation. Importantly, …

Do Not Forget Them, Steve Minton

School of Psychology

Thousands of Indigenous children suffered and died in residential ‘schools’ around the world. Their stories must be heard.

Psychological Trauma In Terrorism (Pt2r): Phase 1 End Of Year Report, Matthew Crayne, Neil Shortland, Jennifer L. Mezzapelle, National Counterterrorism Innovation, Technology, And Education Center

Reports, Projects, and Research

About the Report. This report summarizes the findings of Phase 1 of the PT2R project, a study in the structural design of terrorism and targeted violence research as a profession. Drawn from qualitative analysis of interviews with 35 active terrorism and targeted violence researchers, this report provides a comprehensive job analysis of terrorism research which can be used to inform future selection, assessment, and training of researchers. Additionally, we explore the issue of exposure to traumatic material as a necessary component of terrorism and targeted violence research and identify job-embedded risk factors for psychosocial harm to researchers.

Single-Cell Chromatin Accessibility Profiling Of Acute Myeloid Leukemia Reveals Heterogeneous Lineage Composition Upon Therapy-Resistance, Katarzyna Tomczak, Praveen Barrodia, Shaoheng Liang, Ken Chen, Linghua Wang, Zhongming Zhao, Kunal Rai, Abhinav K Jain, John Dick, Naval Daver, Andy Futreal, Hussein A Abbas

Faculty, Staff and Student Publications

Acute myeloid leukemia (AML) is a heterogeneous disease characterized by high rate of therapy resistance. Since the cell of origin can impact response to therapy, it is crucial to understand the lineage composition of AML cells at time of therapy resistance. Here we leverage single-cell chromatin accessibility profiling of 22 AML bone marrow aspirates from eight patients at time of therapy resistance and following subsequent therapy to characterize their lineage landscape. Our findings reveal a complex lineage architecture of therapy-resistant AML cells that are primed for stem and progenitor lineages and spanning quiescent, activated and late stem cell/progenitor states. Remarkably, …

Targeting Polyploid Giant Cancer Cells Potentiates A Therapeutic Response And Overcomes Resistance To Parp Inhibitors In Ovarian Cancer, Xudong Zhang, Jun Yao, Xiaoran Li, Na Niu, Yan Liu, Guang Peng, Anil K Sood, Jinsong Liu

Faculty, Staff and Student Publications

To understand the mechanism of acquired resistance to poly(ADP-ribose) polymerase inhibitors (PARPi) olaparib, we induced the formation of polyploid giant cancer cells (PGCCs) in ovarian and breast cancer cell lines, high-grade serous cancer (HGSC)-derived organoids, and patient-derived xenografts (PDXs). Time-lapse tracking of ovarian cancer cells revealed that PGCCs primarily developed from endoreplication after exposure to sublethal concentrations of olaparib. PGCCs exhibited features of senescent cells but, after olaparib withdrawal, can escape senescence via restitutional multipolar endomitosis and other noncanonical modes of cell division to generate mitotically competent resistant daughter cells. The contraceptive drug mifepristone blocked PGCC formation and daughter cell …

Single-Cell Sequencing Reveals The Landscape Of The Human Brain Metastatic Microenvironment, Qianqian Song, Jimmy Ruiz, Fei Xing, Hui-Wen Lo, Lou Craddock, Lance D Miller, Stacey S O'Neill, Kounosuke Watabe, Michael D Chan, Jing Su

Faculty, Staff and Student Publications

Brain metastases is the most common intracranial tumor and account for approximately 20% of all systematic cancer cases. It is a leading cause of death in advanced-stage cancer, resulting in a five-year overall survival rate below 10%. Therefore, there is a critical need to identify effective biomarkers that can support frequent surveillance and promote efficient drug guidance in brain metastasis. Recently, the remarkable breakthroughs in single-cell RNA-sequencing (scRNA-seq) technology have advanced our insights into the tumor microenvironment (TME) at single-cell resolution, which offers the potential to unravel the metastasis-related cellular crosstalk and provides the potential for improving therapeutic effects mediated …

Genome-Wide Crispr-Cas9 Screen Analyzed By Slider Identifies Network Of Repressor Complexes That Regulate Trim24, Lalit R Patel, Sabrina A Stratton, Megan Mclaughlin, Patrick Krause, Kendra Allton, Daniela Barbosa, Michelle C Barton

Faculty, Staff and Student Publications

TRIM24 is an oncogenic chromatin reader that is frequently overexpressed in human tumors and associated with poor prognosis. However, TRIM24 is rarely mutated, duplicated, or rearranged in cancer. This raises questions about how TRIM24 is regulated and what changes in its regulation are responsible for its overexpression. Here, we perform a genome-wide CRISPR-Cas9 screen by fluorescence-activated cell sorting (FACS) that nominated 220 negative regulators and elucidated a regulatory network that includes the KAP1 corepressor, CNOT deadenylase, and GID/CTLH E3 ligase. Knocking out required components of these three complexes caused TRIM24 overexpression, confirming their negative regulation of TRIM24. Our findings …

Gold Nanoparticles For Monitoring Of Mesenchymal Stem-Cell-Loaded Bioresorbable Polymeric Wraps For Arteriovenous Fistula Maturation, Allan John R Barcena, Joy Vanessa D Perez, Jossana A Damasco, Marvin R Bernardino, Erin Marie D San Valentin, Benjamin Martin, Gino Martin Canlas, Huckie C Del Mundo, Francisco M Heralde, Rony Avritscher, Natalie Fowlkes, Richard R Bouchard, Jizhong Cheng, Steven Y Huang, Marites P Melancon

Faculty, Staff and Student Publications

Mesenchymal stem cell (MSC)-seeded polymeric perivascular wraps have been shown to enhance arteriovenous fistula (AVF) maturation. However, the wraps' radiolucency makes their placement and integrity difficult to monitor. Through electrospinning, we infused gold nanoparticles (AuNPs) into polycaprolactone (PCL) wraps to improve their radiopacity and tested whether infusion affects the previously reported beneficial effects of the wraps on the AVF's outflow vein. Sprague Dawley rat MSCs were seeded on the surface of the wraps. We then compared the effects of five AVF treatments-no perivascular wrap (i.e., control), PCL wrap, PCL + MSC wrap, PCL-Au wrap, and PCL-Au + MSC wrap-on AVF …

The Red Ribbon And The Black Cross: A Qualitative Study Of The Relationship Between Social Activism And Contemporary Black Church Responses To Hiv In Oakland, Ca, Justise Wattree

McNair Research Journal SJSU

The Black Church as a social institution has been a source of social activism during racial crises, but there is a lacking social activist response by Black churches to HIV’s disparate impact on Black communities. Previous research does not adequately explore the influence of community-based organizations on Black church responses to HIV in the context of social activism. This study examines the relationship between social activism and contemporary Black church responses to HIV in Oakland. It considers community-based organizations (CBOs) as potential drivers of social activism. Semi-structured interviews with Black church leaders in Oakland were conducted and content analyzed along …

#Existenceisresistance: Black Spartans Exhibition, Yeab Kebede

McNair Research Journal SJSU

This research paper explores the intersection of art and social justice, with a specific focus on the Black Spartans (1907-1948) Exhibit that showcased 19 Black students who attended San José State University from 1907 to 1948. The paper argues that art, in the form of visual representation, can serve as a powerful tool to address social injustices and provide a platform for underrepresented voices to be heard. By examining the Black Spartans exhibit, the paper highlights the significance of representation and how it can contribute to social justice movements. The paper also analyzes the impact of the exhibit on the …

The Effects Of Exercise On The Mental Wellness Of Children (Ages 3-6), Reem Farhat

McNair Research Journal SJSU

When it comes to mental health, young children are often not researched and their tantrums or mood swings are not taken seriously, when in reality these small behavioral issues could be pointing to a larger issue. Children are the most overlooked when it comes to mental health diagnosis and treatment, unless the child begins to display extreme behavior (Philpott et al., 2019). However, preventative mental health care is arguably more pragmatic and less taboo than diagnosis and treatment. While there is research to support the use of exercise in mental wellness, there is still not enough done within the children …

The Impact Of Culture On Health Perceptions And Help-Seeking Behaviors Among Older Latinos With Co-Occurring Diabetes And Depression: A Literature Review, Alejandra M. Aguirre

McNair Research Journal SJSU

Diabetes is one of the most common health disparities in the United States today and disproportionately affects older Latino populations. Increased recognition of the bidirectional relationship between diabetes and mental health has led to more awareness and treatments for diabetes and depression. Despite high prevalence rates, diabetes and depression are commonly undiagnosed and untreated in older Latinos. Existing literature reports that factors including genetic and behavioral factors, low socioeconomic status (SES), limited healthcare access, and language barriers may prevent this population from seeking professional treatment. Prior research also suggests that culturally based stigma toward these conditions can negatively impact health …

Full Issue

McNair Research Journal SJSU

No abstract provided.