Digital Commons Network^™

Age-Dependent Dynamics Of Breast Cancer Driven By Mutant P53: Insight From A Mouse Model, Jyotsna Devi Godavarthi

Dissertations (2016-Present)

Breast cancer (BC) incidence increases with age, and a substantial proportion of aggressive forms of BC are observed in older women. The mechanisms underlying BC's age dependence remain unclear. Genetic alterations in BC most frequently occur in the tumor suppressor gene p53, with most mutations occurring somatically at arginine (R) 248 to tryptophan (W) or glutamine (Q) (R248W/Q in humans, corresponding to R245W/Q in mice) mutation. Previously, a conditional mouse p53wmR245W allele was generated. It allowed inducing p53R245W mutant in the mammary epithelium of the p53wmR245W/+ mice by delivering adenovirus expressing Cre (Ad-Cre) into the mammary ducts, …

Internet Drug Prohibition And The Opioid Overdose Crisis, Benjamin A. Barsky

Washington Law Review

The Ryan Haight Online Pharmacy Consumer Protection Act (Ryan Haight Act) prohibits controlled substance tele-prescribing when it occurs without a preliminary in-person medical evaluation. This Article details the Ryan Haight Act’s consequences for the practice of telemedicine in general and opioid addiction treatment in particular. In doing so, it builds on literature exploring the tension between the federal criminal regulation of controlled substance prescribing and the management of large-scale public health crises, particularly the opioid overdose crisis.

By restricting the tele-prescription of certain controlled substances used for opioid addiction treatment, the Ryan Haight Act limits access to care for a …

The President’S Criminal Immunity, Amandeep S. Grewal

SMU Law Review Forum

This Article addresses a monumental question that the Supreme Court will soon decide: does the President enjoy criminal immunity for her official acts? This Article argues that she does.

The potential criminal immunity for official acts has drawn exceptionally sharp critiques. Some scholars believe that the immunity is nonsensical, absurd, or downright offensive. Judge Florence Pan of the D.C. Circuit even posited that criminal immunity would allow the President to murder her political enemies with SEAL Team Six.

This Article shows that the critics are profoundly mistaken. Criminal immunity for a president’s official acts finds a strong foothold in Supreme …

Manor & Meadow, Sydney Schultz

Graphic Communication

With the prevalence of DIY content on platforms like TikTok, many projects lack detailed guidance, making them challenging for individuals to replicate. By offering pre-packaged kits tailored to various interests and skill levels, this project seeks to democratize the DIY experience and empower users to unleash their creativity in a hassle-free manner.

Aita O Paul Gauguin I Ite I Te Parau I Te Reo Tahiti: The Colonial Implications Of Paul Gauguin’S Incorrect Tahitian, Elise Hatch

Pacific Studies

No abstract provided.

Historical And Contemporary Representation Of Kava By Members Of The Church Of Jesus Christ Of Latter-Day Saints, Sione M. U. H. Funaki

Pacific Studies

In Oceania, kava, which is made from the root or stump of the kava shrub, is associated with traditional values such as sacrifice, loyalty, commitment, and chiefliness; it is especially linked with the importance of nurturing vā relationships with fonua—land and people (Kaʻili 2017: 74–75; Tomlinson 2020: 71, 74–75). Kava has also been demonized and mischaracterized since the early nineteenth century as a harmful substance detrimental to the spirit and physical body. The conflicting realities of kava as virtue and vice are expressly displayed in the relationship between kava and the Christian church. Specifically, this paper examines the dynamics between …

Cybersecurity Laws In South Pacific Nations, Siuta Laulaupea’Alu, Te Taka Keegan, Paora Mato

Pacific Studies

Cybersecurity practices and protocols should be updated in terms of human

capacity development and legislative capability to support appropriate responses

to cyberthreats within the island nations and beyond. Recommendations here

discuss awareness and prevention strategies that combat cybercrimes and

cyberattacks and offer pertinent suggestions within cybersecurity strategies

aiming to combat the rapid growth of online fraudulence and crime affecting

nations of the South Pacific. At a national level, suitable frameworks and response

models are essential to instill cybersecurity prevention and awareness. Mandatory

adoption of formal protocols and conventions by businesses and community

and government organizations would underpin regional and national …

Vol. 47 No. 1 (2024): Pacific Studies Front Matter, The Jonathan Nāpela Center For Hawaiian And Pacific Islands Studies

Pacific Studies

Front Matter for the Vol. 47, No 1-Jun 2024 edition of the Pacific Studies Journal.

Autonomy And Creativity In ‘Epeli Hau‘Ofa And The Lo‘Au University Philosophy Of Education For Thinking, Siosiua F. P. Lafitani (LoʻAu VavangakitupuʻA)

Pacific Studies

The spirit of autonomy and creativity in Epeli Hau‘ofa’s writings that relate to the

philosophy of the Lo‘au University of education for thinking is explored here.

For Hau‘ofa, the spirit of free thinking aids Moanan (Pacific people) to redefine

their identity in Moana (Oceania) and worldwide. The philosophy of education

for thinking is applied here to highlight that a degree of autonomy and creativ-

ity can be planted and grown in Moana. Free thinking ought to be central to

research projects that strive for autonomy and creativity if twenty-first century

Moanan people want their intellectualism to be a permanent …

Vol. 47 No. 1 (2024): Pacific Studies Full Issue, The Jonathan Nāpela Center For Hawaiian And Pacific Islands Studies

Pacific Studies

Pacific Studies is published two times a year by The

Jonathan Nāpela Center for Hawaiian and Pacific Studies, Brigham Young

University Hawai‘i #1979, 55–220 Kulanui Street, Lā ‘ie, Hawai‘i 96762, but

responsibility for opinions expressed in the articles rests with the authors alone.

Subscription rate is US$40.00 yearly, payable to The Jonathan Nāpela Center

for Hawaiian and Pacific Studies. The Jonathan Nāpela Center for Hawaiian

and Pacific Studies (formerly The Pacific Institute) is an organization funded

by Brigham Young University Hawai‘i. The Center assists the University in

meeting its cultural and educational goals by undertaking a program of teach-

ing, …

Provisioning The 21st Century City: Community And School Gardens As Food Centers, Charleen L. Kepner

Anthós

This essay explores the potential impact of urban agriculture and community gardens as sources of education and sustainable and environmentally-sound food production. Using an analysis of case studies and academic research, I argue for the viability of community gardens and urban agriculture as educational hubs and future food production sources. I examine previous research which shows that small scale effort can make lasting impacts in communities. I argue that the research is promising as it highlights that the efforts of people in their everyday lives, can and do contribute to positive change. This essay contributes to the ongoing discussion of …

Mycoplasmoides Genitalium Nucleic Acid Semi-Quantitation And Molecular Macrolide Resistance Detection Via Automated Assays: Gender And Specimen Source Considerations, Erik Munson, Josephine Moore, Trinity Kreuger, Amanda Zapp, Stephen C. Lavey, Kimber L. Munson, Irene A. Stafford, Brian Mustanksi

Clinical Lab Sciences Faculty Research and Publications

A laboratory-developed test (LDT) using analyte-specific reagents has been optimized on a commercial platform to detect macrolide resistance-associated mutations (MRM) in 23S rRNA from Mycoplasmoides genitalium from primary clinical specimens. In this study, MRM-LDT was applied to a multi-specimen source study set. One thousand four hundred ninety-five primary specimens testing positive for M. genitalium by commercial transcription-mediated amplification (TMA) were initially titered by the TMA assay using serial 10-fold dilutions to semi-quantitate target nucleic acid burden. Primary specimens were then processed for MRM detection using the MRM-LDT. Findings were stratified by gender and specimen source. The mean log₁₀ target …

Rates Of Urinary Tract Infection In Transgender Women Postvaginoplasty Vs Cisgender Women: A Retrospective Cohort Study In A Large Us Health Network, David Gilbert, Aishwarya Gautam, Tomasz Tabernacki, Megan Mcnamara, Rachel Pope, Shubham Gupta, Kirtishri Mishra

Student Scholarship

Objective: To describe urinary tract infection (UTI) risk 3-month postvaginoplasty (VP) in transgender women (TW) compared to cis women (CW). Methods: Using TriNetX (TriNetX, Inc, Cambridge, MA), we built cohorts of 2041 TW and 48,374,745 CW. Outcomes were ≥1 instance of UTI or Cystitis, and assessed from 3-6, 3-12, 3-36 months, and 3 months-10 years post-VP. TW and CW were age-cohorted (18-39, 40-59, 60-74) and compared at each time interval. Kaplan-Meier was used to account for loss to follow-up, along with hazard ratios and log-rank tests to determine significance (P <.05). Results: For all time intervals and age ranges, TW had a significantly (P <.0001-P = .0088) higher probability of developing a UTI compared to CW. The largest difference was ages 40-59 ten-year post-VP. In this analysis, CW and TW had a 12.96% and 29.34% cumulative outcome incidence, respectively. Cox proportional hazard analysis demonstrated increased hazard for TW compared to CW. Hazard ratios between CW and TW ranged from 1.363 (ages 18-39 at 10 years, 95%CI: 1.119,1.660) to 3.522 (ages 60-74 at 12 months, 95%CI: 1.951,6.360). Conclusion: We found a significantly higher probability of TW developing UTIs compared to age-cohorted CW. Contributing factors may include difficulties with neovaginal perineal hygiene, lack of commensal bacteria and vaginal mucosa, larger urethral meatus, high rates of meatal stenosis, and nonnative bacteria introduced through dilators and douching. These findings may help improve quality of postoperative care in TW.

A Generic Blood Banking And Transfusion Process-Oriented Architecture For Virtual Organizations, Anwar Rjoop, Shaima Elhaj, Dina Tbaishat, Yousra Odeh, Asem Mansour, Mohammed Odeh

All Works

Background Blood banks are an important part of healthcare systems. They embrace critical processes that start with donor recruitment and blood collection, followed by blood processing to produce different types of blood components used in transfusions, blood storage, blood distribution, and transfusion. Blood components must be generated at high quality, preserved safely, and transfused in a timely manner. This can be achieved by operating interrelated processes within a complex network. There is no comprehensive blueprint of Blood Banking and Transfusion (BB&T) processes and their relationships; therefore, this study aims to develop and evaluate a BB&T process architecture using the Riva …

An Experimental Study Of Supervised Machine Learning Techniques For Minor Class Prediction Utilizing Kernel Density Estimation: Factors Impacting Model Performance, Abdullah Mana Alfarwan

Dissertations

This dissertation examined classification outcome differences among four popular individual supervised machine learning (ISML) models (logistic regression, decision tree, support vector machine, and multilayer perceptron) when predicting minor class membership within imbalanced datasets. The study context and the theoretical population sampled focus on one aspect of the larger problem of student retention and dropout prediction in higher education (HE): identification.

This study differs from current literature by implementing an experimental design approach with simulated student data that closely mirrors HE situational and student data. Specifically, this study tested the predictive ability of the four ISML classification models (CLS) under experimentally …

Alternative Adjacency Matrices And Spatial Analysis, Jaeseong Hwang

Dissertations

Spatial analysis is essential for comprehending the spatial distribution of diseases and various phenomena across geographic regions. This study investigates the utilization of alternative adjacency matrices in spatial analysis, with a specific focus on implementing Poisson regression models. This study intricately explores the methodology behind constructing alternative weight matrices, specifying weight matrices, and comparing the performance of Poisson models using five different weight matrices.

The popular Poisson model model is described, and five different definitions of weight matrices are defined, which are the following: binary weight matrix, inverse distance weight matrix using Euclidean distance, Graph distance matrix, Path matrix, and …

Analysis Of Rural Broadband Adoption Dynamics: A Theory-Driven Agent-Based Model, Ankit Agarwal, Casey Canfield

Engineering Management and Systems Engineering Faculty Research & Creative Works

Demand for broadband internet has far outpaced its availability. In addition, the "new normal" imposed by the COVID-19 pandemic has further disadvantaged unserved and underserved areas. To address this challenge, federal and state agencies are funding internet service providers (ISPs) to deploy broadband infrastructure in these areas. To support goals to provide broadband service to as many people as possible as quickly as possible, policymakers and ISPs may benefit from better tools to predict take rates and formulate effective strategies to increase the adoption of high-speed internet. However, there is typically insufficient data available to understand consumer attitudes. We propose …

The Securities And Environment Commission? The Sec Greenhouse Gas Disclosure Rule For Investment Advisers And Companies And The Fight Against Administrative Overreach, Isaiah P. Harlan

Northern Illinois University Law Review

This article discusses the 2022 Supreme Court case West Virginia v. EPA in which the Supreme Court utilized the Major Questions Doctrine to analyze the EPA’s Clean Power Plan. After detailing the litigation leading up to and the ultimate decision in West Virginia v. EPA, I describe the SEC’s proposed rule requiring enhanced environmental disclosures and analyze the cited statutory authority in the proposed rule. Based upon the statutory and case law analysis that I have done, I conclude that the SEC has acted outside of the scope of its congressionally delegated authority.

Esg Factors In Municipal Securities Disclosures: Toward A Materiality Concept, Justin Marlowe

Northern Illinois University Law Review

State and local governments in the United States finance most of their infrastructure investment with debt instruments known as municipal bonds. The federal government does not directly regulate when or how municipal issuers access the municipal bond market, and only indirectly regulates the content of municipal borrowers’ disclosure to investors. A consequence of that unique regulatory structure is that municipal borrowers have wide discretion on whether to disclose falling property values, rising crime rates, and other long-term threats to their ability to repay investors. This is at odds with the ever-expanding information needs of investors who seek to align their …

Firearms Carceralism, Jacob D. Charles

Minnesota Law Review Vols. 106:2 onward (2021-present)

Gun violence is a pressing national concern. And it has been for decades. Throughout nearly all that time, the primary tool lawmakers have deployed to stanch the violence has been the machinery of the criminal law. Increased policing, intrusive surveillance, vigorous prosecution, and punitive penalties are showered on gun offenders. This Article spotlights and specifies this approach--what it calls “firearms carceralism”--and details how a decades-long bipartisan consensus generated a set of state-centered solutions to gun violence that has not meaningfully impacted the problem. Instead, those policies have exacerbated racial inequity and compounded civic and community harms. The Article traces the …

Scientific Context, Suicide Prevention, And The Second Amendment After Bruen, Eric Ruben

Minnesota Law Review Vols. 106:2 onward (2021-present)

The Supreme Court declared in New York State Rifle & Pistol Ass'n v. Bruen that modern gun laws must be “consistent with this Nation's historical tradition of firearm regulation” to survive Second Amendment challenges. Scholarship has shown how this test of historical analogy presents difficulties because of how technological, legal, and social change has shaped policy over the centuries. This Article is the first to assess Bruen as it applies to suicide-prevention laws, and, in doing so, illuminates another form of change that complicates Bruen's implementation: scientific progress. As this Article shows, early generations of Americans fundamentally misunderstood mental illness …

Actg 698.01: Business Internship, Michelle Schwartz

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Strategic Integration Of Ai In Higher Education And Industry: The Ai8-Point Model, Emily Barnes, James Hutson

Faculty Scholarship

The AI8-Point Model, derived from extensive experience in technology, AI, and higher education administration, addresses the critical need for cost-effective, high-impact strategies tailored to higher education. Despite the transformative potential of AI in enhancing student engagement, optimizing processes, and improving educational outcomes, institutions often struggle with practical implementation. The AI8-Point Model fills this gap by offering strategies that balance cost and impact. Visualized as a circle divided into four quadrants, the model encompasses phases of student engagement and institutional interaction: pre-enrollment beyond institutional control, pre-enrollment within institutional control, post-enrollment within institutional control, and post-enrollment beyond institutional control. Each quadrant contains …

Bmgt 498.01: Internship, Michelle Schwartz

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Edld 551.50: Foundations Of Curriculum Leadership, William P. Mccaw

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Evaluation Of Ten Alternative Treatments For The Management Of Harlequin Bug (Murgantia Histrionica) On Brassica Crops, Sarah Clark, Ricardo Bessin, David J. Gonthier, Jonathan L. Larson

Entomology Faculty Publications

Harlequin bug (Murgantia histrionica) poses a significant threat to cruciferous vegetable crops, leading to economic losses and challenges in sustainable agriculture. This 2-year field study evaluated the efficacy of exclusion netting and selected biopesticides in controlling harlequin bug populations in a field-grown broccoli crop. Treatments included an untreated control, industry standards Azera and Entrust, and ProtekNet mesh netting. Additionally, three commercial essential oil treatments including Essentria IC-3, Nature-Cide, and Zero Tolerance were tested along with two bokashi fermented composting products BrewKashi and Oriental Herbal Nutrient (OHN). During both the first and second year of the study, none of the commercially …

Row Covers Limit Pests And Disease And Increase Profit In Organic Acorn Squash, Kathleen Fiske, Nieyan Cheng, Ryan Kuesel, Wendong Zhang, Ricardo Bessin, Mark A. Williams, David J. Gonthier

Entomology Faculty Publications

Organic cucurbit growers face many challenges to production including insect pests, insect-vectored diseases, and non-vectored diseases. While Organic Material Review Institute (OMRI) -listed pesticides underperform at suppressing pests and diseases, some alternative pest management strategies hold promise, but little research exists on their cost-effectiveness. We compared the efficacy of mesotunnel systems (nylon-mesh netting row covers deployed over bent metal hoops) and OMRI-listed pesticides (fungicides and insecticides) on acorn squash across 2 years. During the early part of the season, before row covers were removed for pollination, we found 1.7 (2020) and 0.3 (2021) times more cucumber beetles in the uncovered …

Snpaimer: R Package For Evaluating Ancestry Informative Marker Contributions In Non-Model Population Diagnostics, Kim L. Vertacnik, Oksana V. Vernygora, Julian R. Dupuis

Entomology Faculty Publications

Motivation: Single nucleotide polymorphism (SNP) markers are increasingly popular for population genomics and inferring ancestry for individuals of unknown origin. Because large SNP datasets are impractical for rapid and routine analysis, diagnostics rely on panels of highly informative markers. Strategies exist for selecting these markers, however, resources for efficiently evaluating their performance are limited for non-model systems.

Results: snpAIMeR is a user-friendly R package that evaluates the efficacy of genomic markers for the cluster assignment of unknown individuals. It is intended to help minimize panel size and genotyping effort by determining the informativeness of candidate diagnostic markers. Provided genotype data …

Staufenc Facilitates Utilization Of The Erad Pathway To Transport Dsrna Through The Endoplasmic Reticulum To The Cytosol, Jinmo Koo, Subba R. Palli

Entomology Faculty Publications

RNA interference (RNAi) is more efficient in coleopteran insects than other insects. StaufenC (StauC), a coleopteran-specific double-stranded RNA (dsRNA)-binding protein, is required for efficient RNAi in coleopterans. We investigated the function of StauC in the intracellular transport of dsRNA into the cytosol, where dsRNA is digested by Dicer enzymes and recruited by Argonauts to RNA-induced silencing complexes. Confocal microscopy and cellular organelle fractionation studies have shown that dsRNA is trafficked through the endoplasmic reticulum (ER) in coleopteran Colorado potato beetle (CPB) cells. StauC is localized to the ER in CPB cells, and StauC-knockdown caused the accumulation of dsRNA in the …

Bureaucracies In Information Securing: Transitioning From Iron Cages To Iron Shields, Yaojie Li, Clay Posey, Thomas Stafford

Management and Marketing Faculty Publications

Drawing inspiration from bureaucracy and information security literature, we develop the theory of security bureaucracy—an evolutionary framework that describes how organizations arrive at their information-securing approaches. Within this framework, we describe three general bureaucratic archetypes (i.e., Security Prototype, Security Structure, and Security Superstructure) that emerge from the interplay between control and expertise. We also expound on the phenomenon of security bureaucracy and delineate how organizations can transition from coercive “iron cages” to enabling “iron shields” in information securing. We also use our security establish-enforce-enculturate (3E) evolutionary framework to inform a proposed variance model of security bureaucracy. Our efforts offer significant …