Digital Commons Network^™

A Program Evaluation Of 3de Schools By Junior Achievement, Audra Lewis-Hoesch

Dissertations

3DE Schools by Junior Achievement is a framework for instruction designed to reshape the instructional ecosystem through a high school model that uses project-based learning and case-study methodology to help students acquire core competencies. The context of this inquiry includes various states in America where 3DE Schools are implemented. I utilized a mixed methods approach to collect data and gauge the influence of the 3DE instructional framework on students' readiness for college and career pursuits. Key outcomes showed that students in 3DE cohorts scored higher in math and English than the national average, contributing to an overall higher graduation rate …

An Exploration Of Contributors To Intergenerational Trauma Transmission In American Families: Parental Life Experiences And Parenting Styles., Shantrell P. Sutton-Mckenzie

Dissertations

Preexisting research on intergenerational trauma transmission primarily addresses biological and behavioral routes of transmission, leaving little room for systemic influences. This research reviews preexisting biological and behavioral contributors and explores systemic contributors to intergenerational trauma transmission in American families as it relates to post-traumatic growth, parental centrality distress, and parenting styles. It was that post-traumatic growth and parental centrality of distress (comprised of ACES, centrality of events, and access to community resources) and PTG predict parenting styles. The research hypothesis was partially supported. It was found (1) Post-traumatic growth, ACEs, and perceived access to community resources while parenting added significantly …

Metastasectomy For Extracalvarial Renal Cell Carcinoma, Rahim Abo Kasem, Karan Joseph, Adnan Shaik, Angela Downes, M Burhan Janjua

2020-Current year OA Pubs

KEY CLINICAL MESSAGE: Palliative surgical resection of extra-calvarial metastatic lesions from renal cell tumors is crucial for controlling metastatic spread, improving quality of life, and preventing associated morbidity. Careful surgical planning, including selective preoperative embolization and controlled resection around critical structures such as the sagittal sinus, is essential for successful outcomes. Cranioplasty with Titanium mesh and bone cement post-resection can provide symptomatic relief, better cosmesis, and overall improved quality of life.

ABSTRACT: Renal cell carcinomas are aggressive tumors with distant systemic disease. The calvarium appears to be an unusual and rare site for distant metastasis. The treatment modalities are challenging …

An Evaluation Of The Outcomes Associated With Peritoneal Catheter Use In Neonates Undergoing Cardiac Surgery: A Multicenter Study, David M Kwiatkowski, Tara M Neumayr, Et Al.

2020-Current year OA Pubs

OBJECTIVE: The study objective was to determine if intraoperative peritoneal catheter placement is associated with improved outcomes in neonates undergoing high-risk cardiac surgery with cardiopulmonary bypass.

METHODS: This propensity score-matched retrospective study used data from 22 academic pediatric cardiac intensive care units. Consecutive neonates undergoing Society of Thoracic Surgeons-European Association for Cardio-Thoracic Surgery category 3 to 5 cardiac surgery with cardiopulmonary bypass at centers participating in the NEonatal and Pediatric Heart Renal Outcomes Network collaborative were studied to determine the association of the use of an intraoperative placed peritoneal catheter for dialysis or passive drainage with clinical outcomes, including the …

Trace Element Contamination In Urban Soils: Testing And Management, Melissa Chilinski, Melanie Stock, Paul R. Grossl, Eli Oliver

All Current Publications

Trace elements, often referred to as heavy metals, naturally occur in the soil at low levels. Certain land use histories can elevate the concentrations of trace elements to levels that present health risks. Understanding which elements and soil test values may impact human or crop health is an important aspect of gardening and micro-farming, particularly in urban environments that are at increased risk of soil contamination. This fact sheet provides instructions on interpreting soil test results for trace elements through the Total Element Composition EPA 3050B Soil Test (#S19) at Utah State University Analytical Laboratory.

Late-Season Influenza Vaccine Effectiveness Against Medically Attended Outpatient Illness, United States, December 2022-April 2023, Jessie R Chung, Stacey L House, Tara Curley, Et Al.

2020-Current year OA Pubs

BACKGROUND: The 2022-23 US influenza season peaked early in fall 2022.

METHODS: Late-season influenza vaccine effectiveness (VE) against outpatient, laboratory-confirmed influenza was calculated among participants of the US Influenza VE Network using a test-negative design.

RESULTS: Of 2561 participants enrolled from December 12, 2022 to April 30, 2023, 91 laboratory-confirmed influenza cases primarily had A(H1N1)pdm09 (6B.1A.5a.2a.1) or A(H3N2) (3C.2a1b.2a.2b). Overall, VE was 30% (95% confidence interval -9%, 54%); low late-season activity precluded estimation for most subgroups.

CONCLUSIONS: 2022-23 late-season outpatient influenza VE was not statistically significant. Genomic characterization may improve the identification of influenza viruses that circulate postinfluenza peak.

Leveraging Digital Media To Promote Youth Mental Health: Flipping The Script On Social Media-Related Risk, Jessica L Hamilton, John Torous, Hannah S Szlyk, Candice Biernesser, Kaylee P Kruzan, Michaeline Jensen, Jazmin Reyes-Portillo, Brian A Primack, Jamie Zelazny, Paul Weigle

2020-Current year OA Pubs

PURPOSE OF REVIEW: Despite growing public concern about the negative impact of digital media for mental health problems, there are key ways in which digital media can be leveraged to prevent such outcomes. This article reviews research exploring the ways that digital media, particularly social media, can be used to prevent negative mental health outcomes and promote youth mental health and well-being.

RECENT FINDINGS: Research indicates that media can be protective against mental health problems and promote mental health by enabling social support and destigmatizing mental illness, especially for youth with limited resources. Media also can be leveraged to identify …

Retrospective Multicenter Cohort Study On Safety And Electroencephalographic Response To Lacosamide For Neonatal Seizures, Moninder Kaur, Rejean M Guerriero, Renée A Shellhaas, Et Al.

2020-Current year OA Pubs

BACKGROUND: There is growing evidence supporting the safety and effectiveness of lacosamide in older children. However, minimal data are available for neonates. We aimed to determine the incidence of adverse events associated with lacosamide use and explore the electroencephalographic seizure response to lacosamide in neonates.

METHODS: A retrospective cohort study was conducted using data from seven pediatric hospitals from January 2009 to February 2020. For safety outcomes, neonates were followed for ≤30 days from index date. Electroencephalographic response of lacosamide was evaluated based on electroencephalographic reports for ≤3 days.

RESULTS: Among 47 neonates, 98% received the first lacosamide dose in …

Genome-Wide Association Studies And Mendelian Randomization Analyses Provide Insights Into The Causes Of Early-Onset Colorectal Cancer, R S Laskar, Y Cao, Et Al.

2020-Current year OA Pubs

BACKGROUND: The incidence of early-onset colorectal cancer (EOCRC; diagnosed < 50 years of age) is rising globally; however, the causes underlying this trend are largely unknown. CRC has strong genetic and environmental determinants, yet common genetic variants and causal modifiable risk factors underlying EOCRC are unknown. We conducted the first EOCRC-specific genome-wide association study (GWAS) and Mendelian randomization (MR) analyses to explore germline genetic and causal modifiable risk factors associated with EOCRC.

PATIENTS AND METHODS: We conducted a GWAS meta-analysis of 6176 EOCRC cases and 65 829 controls from the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO), the Colorectal Transdisciplinary Study (CORECT), the Colon Cancer Family Registry (CCFR), and the UK Biobank. We then used the EOCRC GWAS to investigate 28 modifiable risk factors using two-sample MR.

RESULTS: We found two novel risk loci for EOCRC at 1p34.1 and 4p15.33, which were not previously associated with CRC risk. We identified a deleterious coding variant (rs36053993, G396D) at polyposis-associated DNA repair gene MUTYH …

Downstream Biomarker Effects Of Gantenerumab Or Solanezumab In Dominantly Inherited Alzheimer Disease: The Dian-Tu-001 Randomized Clinical Trial, Olivia Wagemann, Haiyan Liu, Guoqiao Wang, Xinyu Shi, David B Clifford, Charlene Supnet-Bell, Anna M Santacruz, Andrew J Aschenbrenner, Jason J Hassenstab, Tammie L S Benzinger, Brian A Gordon, Carlos Cruchaga, Laura Ibanez, Richard J Perrin, Chengjie Xiong, Yan Li, John C Morris, Jorge Llibre-Guerra, Randall J Bateman, Eric Mcdade, Et Al.

2020-Current year OA Pubs

IMPORTANCE: Effects of antiamyloid agents, targeting either fibrillar or soluble monomeric amyloid peptides, on downstream biomarkers in cerebrospinal fluid (CSF) and plasma are largely unknown in dominantly inherited Alzheimer disease (DIAD).

OBJECTIVE: To investigate longitudinal biomarker changes of synaptic dysfunction, neuroinflammation, and neurodegeneration in individuals with DIAD who are receiving antiamyloid treatment.

DESIGN, SETTING, AND PARTICIPANTS: From 2012 to 2019, the Dominantly Inherited Alzheimer Network Trial Unit (DIAN-TU-001) study, a double-blind, placebo-controlled, randomized clinical trial, investigated gantenerumab and solanezumab in DIAD. Carriers of gene variants were assigned 3:1 to either drug or placebo. The present analysis was conducted from April …

Ascc1 Structures And Bioinformatics Reveal A Novel Helix-Clasp-Helix Rna-Binding Motif Linked To A Two-Histidine Phosphodiesterase, Naga Babu Chinnam, Jennifer M Soll, Nima Mosammaparast, Et Al.

2020-Current year OA Pubs

Activating signal co-integrator complex 1 (ASCC1) acts with ASCC-ALKBH3 complex in alkylation damage responses. ASCC1 uniquely combines two evolutionarily ancient domains: nucleotide-binding K-Homology (KH) (associated with regulating splicing, transcriptional, and translation) and two-histidine phosphodiesterase (PDE; associated with hydrolysis of cyclic nucleotide phosphate bonds). Germline mutations link loss of ASCC1 function to spinal muscular atrophy with congenital bone fractures 2 (SMABF2). Herein analysis of The Cancer Genome Atlas (TCGA) suggests ASCC1 RNA overexpression in certain tumors correlates with poor survival, Signatures 29 and 3 mutations, and genetic instability markers. We determined crystal structures of Alvinella pompejana (Ap) ASCC1 and Human (Hs) …

Changes In Online Marketing And Sales Practices Among Non-Medical Cannabis Retailers In 5 Us Cities, 2022 To 2023, Yuxian Cui, Zongshuan Duan, Cassidy R Loparco, Katie Vinson, Katelyn F Romm, Yan Wang, Patricia A Cavazos-Rehg, Erin Kasson, Y Tony Yang, Carla J Berg

2020-Current year OA Pubs

OBJECTIVES: Given the evolving cannabis marketplace (e.g., products, marketing strategies), this study examined online cannabis marketing practices over time.

METHODS: In 2022 and 2023, researchers assessed website content (e.g., age verification, sales, delivery, warnings, ad content, promotional strategies) among 175 randomly-selected cannabis retailers' websites across 5 US cities (Denver, Colorado; Seattle, Washington; Portland, Oregon; Las Vegas, Nevada; Los Angeles [LA], California, n=∼35/city). Analyses compared data from 2022 vs. 2023 and considered regulatory factors across cities.

RESULTS: Similar to 2022, in 2023, 76.6 % required age verification for site entry, 85.1 % used social media promotion, and 90.9 % offered online …

Spatially Resolved Metabolomic Dataset Of Distinct Human Kidney Anatomic Regions, Haikuo Li, Benjamin D Humphreys

2020-Current year OA Pubs

Cortex, medulla and papilla are three major human kidney anatomic structures and they harbour unique metabolic functions, but the underlying metabolomic profiles are largely unknown at spatial resolution. Here, we generated a spatially resolved metabolomics dataset on human kidney cortex, medulla and papilla tissues dissected from the same donor. Matrix-Assisted Laser Desorption/Ionization-Imaging Mass Spectrometry (MALDI-IMS) was used to detect metabolite species over mass-to-charge ratios of 50 -1500 for each section at a resolution of 10 × 10 µm

Real-World Experience With Avacopan In Antineutrophil Cytoplasmic Autoantibody-Associated Vasculitis, Reza Zonozi, Aisha Shaikh, Colin Diffie, Et Al.

2020-Current year OA Pubs

INTRODUCTION: Postmarketing data on outcomes of avacopan use in antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) are lacking.

METHODS: We performed a multicenter retrospective analysis of 92 patients with newly diagnosed or relapsing AAV who received therapy with avacopan. The coprimary outcome measures were clinical remission at 26 and 52 weeks. We use descriptive statistics and univariate logistic regression to assess outcomes and predictors of remission, respectively.

RESULTS: Of the 92 patients, 23% (n = 21) had a baseline estimated glomerular filtration rate (eGFR) < 15 ml/min per 1.73 m

CONCLUSION: A high rate of remission and an acceptable safety profile were observed with the use of …

Subunit Communication Within Dimeric Sf1 Dna Helicases, Binh Nguyen, John Hsieh, Christopher J Fischer, Timothy M Lohman

2020-Current year OA Pubs

Monomers of the Superfamily (SF) 1 helicases, E. coli Rep and UvrD, can translocate directionally along single stranded (ss) DNA, but must be activated to function as helicases. In the absence of accessory factors, helicase activity requires Rep and UvrD homo-dimerization. The ssDNA binding sites of SF1 helicases contain a conserved aromatic amino acid (Trp250 in Rep and Trp256 in UvrD) that stacks with the DNA bases. Here we show that mutation of this Trp to Ala eliminates helicase activity in both Rep and UvrD. Rep(W250A) and UvrD(W256A) can still dimerize, bind DNA, and monomers still retain ATP-dependent ssDNA translocase …

Genetic Loci Regulate Sarbecovirus Pathogenesis: A Comparison Across Mice And Humans, Alexandra Schäfer, Laura A Vanblargan, Larissa B Thackray, Michael S Diamond, Et Al.

2020-Current year OA Pubs

Coronavirus (CoV) cause considerable morbidity and mortality in humans and other mammals, as evidenced by the emergence of Severe Acute Respiratory CoV (SARS-CoV) in 2003, Middle East Respiratory CoV (MERS-CoV) in 2012, and SARS-CoV-2 in 2019. Although poorly characterized, natural genetic variation in human and other mammals modulate virus pathogenesis, as reflected by the spectrum of clinical outcomes ranging from asymptomatic infections to lethal disease. Using multiple human epidemic and zoonotic Sarbecoviruses, coupled with murine Collaborative Cross genetic reference populations, we identify several dozen quantitative trait loci that regulate SARS-like group-2B CoV pathogenesis and replication. Under a Chr4 QTL, we …

Transient Cortical Weakness Following Cerebral Angiography: A New Syndrome, Akash P Kansagra, Richard Pham, Arindam R Chatterjee, Christopher J Moran

2020-Current year OA Pubs

Transient cortical blindness is a known complication of iodinated contrast administration and is believed to reflect osmotic injury or autoregulatory dysfunction of the posterior circulation. Here, we report 2 cases of postangiography transient cortical

Hong Kong’S Architectural Resistance: Practice Through Research, Jingjing Huang

Masters Theses

This thesis research politically charged public spaces in Hong Kong due to the past social movements and acknowledges its uniqueness formed by the intuitive use of the vernacular public spaces in the context of both day-to-day life and social movements. The way of freely utilizing elements in public spaces makes the public space in Hong Kong a space to be, a space to express, and a space to resist. However, a unique public space like this often causes misunderstanding, misrepresentation, and sometimes fear from other sides. Thus, this thesis aims to create a subjective analytical view of the formation and …

Gender Disparity In Students’ Performance Of Science And Mathematics: Evidence From Nationwide Study In Pakistan, Sadia Muzaffar Bhutta, Aisha Naz Ansari, Sohail Ahmad

Institute for Educational Development, Karachi

Gender disparity in science and mathematics performance is being researched internationally. In a complex education system, like Pakistan, studying the difference in isolation may not generate holistic understanding. Therefore, this paper investigates changes in trends of performance in Science and Mathematics for both genders across public and private schools. Data were gathered from a nationwide sample of elementary grades students (n=15,391) using SATs/MATS. Independent t-test and two-way-ANOVA were employed to analyse data. Results revealed that girls outperformed boys in Science (p<0.01) while no gender differences in performance were observed in Mathematics. Gender and school systems demonstrated significant interaction effect only in mathematics, unveiling that girls perform better in public schools while this difference diminished in the private school system. The results show implications for employing gender-fair policies and practices in science and mathematics education.

Lucid Dream: Embracing Uncertainty, Zhiyun Zhang

Masters Theses

Glass is a tool, a projection surface, a medium for optical phenomena. It creates a tangible link between physical space and perception, transcending the physical realm to reshape our sensory perceptions and resonate within our psyche, deepening our understanding. Inspired by cosmic and natural phenomena, my installations narrate the contemplation of the moon and the appreciation of rainbows. They reference historic optical technologies, incorporating glass, mirrors, light, darkness, and space to produce an encounter that extends beyond personal experience, resonating with our collective unconscious, uniting us in profound ways. The blurred boundaries between observer and observed, reality and illusion, sensory …

Milpa: Cultivating Community Through Grid Remediation In México, Marianna Pasaret Molinar

Masters Theses

In México, the proliferation of monotonous affordable housing developments on the outskirts of urban centers stems from a profit- driven approach that prioritizes rapid construction over livability and community well-being. These housing developments, stark rows of barren husks, reflect a system that depletes both land and human connection. Abandoned units — consequences of a patchwork (or non existent) infrastructure —now stand as silent critiques of this broken system.

Drawing inspiration from the cycical strategies of ancestral agricultural traditions, that recognize the full spectrum from barren stalk to abundance, this project proposes a cyclical model for community growth. Current housing practices, …

忘年交 / A Friendship That Transcends Age, Zichen Zhou

Masters Theses

In today’s swiftly aging society, China grapples with the challenge of elderly individuals gradually becoming disconnected from the social fabric, often leading to the phenomenon of empty-nesting, especially in China’s eastern urban areas. Understanding and addressing the needs of the elderly is crucial for designing environments, that give continued meaning to the lives of the elderly, and create connections with the rest of society. Further, the elderly are a resource for families, capable of providing childcare and even housing to younger generations, whether the younger generations want this help or not. In response to the challenge of keeping the elderly …

An Abundance Of Caution, Gonçalo Preto Jorge

Masters Theses

Abstract

An Abundance of Caution

3 puffs and breathing stabilizes...

Must have been the pollen last night.

Quiça

An eerie sense of emptiness takes over

And incidentally

The inability to express and verbalize any articulated thought.

Quiça

I seek sensations...experiences. To indulge.

The fascination with dreamscapes hails from the daunting lack of them.

Poooooxa

I listen, imagine, and process scenarios around me

In a precarious attempt to interpret and translate instances into something meaningful.

Oxalá, Matéria pictórica.

Oxalá.

I see my shadow but only an elusive silhouette

I observe the way it follows the wall and fades into the sidewalk, …

Comparative Analysis Of Motors With Inner And Outer Reluctance Rotors And Pm Stators, Oluwaseun A. Badewa, Dan M. Ionel

Electrical and Computer Engineering Graduate Research

This paper presents a comparison of special outer and inner reluctance rotor motor topologies with permanent magnet (PM) stators having toroidal AC windings. A systematic approach is taken to study and discuss the design geometries, the respective impact on performance, and adoption of technological advancements such as stator-only cooling and hair-pin winding for high slot fill factor. Parametric FEA models are developed for both topologies, and design of experiments (DoE)-based sensitivity analysis is used to study the effect of independent variables on specific performance metrics such as torque, motor loss, torque ripple, and power factor. Inner and outer rotor topologies …

Sensorless Control Of Low Inductance Coreless Afpm Machines For Fault-Tolerant Operation Of Propulsion Systems, Yaser Chulaee, Ali Mohammadi, Aaron M. Cramer, Dan M. Ionel

Electrical and Computer Engineering Graduate Research

In motor-drive systems utilized in safety-critical applications and demanding conditions like electric aircraft propulsion systems, the reliability of the system is greatly affected by position sensors, given their susceptibility within the motor drive system. Consequently, there is a need to eliminate sensors in vector-controlled motor drives to decrease overall hardware complexity and expenses, bolster the mechanical durability and dependability of the drive system. In this paper, a fault-tolerant sensorless control system for low inductance coreless axial flux PM (AFPM) machines, integrated into electric aircraft propulsion systems, is introduced. The proposed control system spans a wide operating range, from zero to …

Fault-Tolerant Axial Flux Coreless Pm Machines With Independent Phase Modules, Yaser Chulaee, Ali Mohammadi, Dan M. Ionel, Matin Vatani

Electrical and Computer Engineering Graduate Research

In this paper, a fault-tolerant two-phase high power coreless axial flux PM (AFPM) machine with a modular structure is introduced. The performance of this machine, in terms of torque, power density, and efficiency, is compared with its three-phase counterpart configuration based on finite element analysis (FEA) and experimental results. The fault tolerance of these two configurations, considering the control systems, is also compared. A detailed power loss breakdown for the prototype two-phase and three-phase printed circuit board (PCB) stator coreless AFPM machines derived from experiments is presented, showcasing that the introduced fault-tolerant two-phase machine has comparable performance and efficiency, while …

High-Power Polyphase Pcb-Type Inductive Coupler For Wireless Electric Vehicle Charging, Donovin D. Lewis, Omer Onar, Lucas Gastineau, John F. Eastham, Dan M. Ionel

Electrical and Computer Engineering Graduate Research

The cost and manufacturing difficulty of traditionally wound coils for wireless charging of electric vehicles has led to the exploration of alternative manufacturing for scalable deployment at a range of rated powers. A rotating-field polyphase wireless coupler is developed with balanced fully pitched coils which are not possible with conventional Litz wire. The usage of printed circuit board (PCB) technology is proposed for the innovative construction at large dimensions due to reduced cost, increased ease of manufacturability, and potential geometric customization compared to would coils. Design considerations specific to PCBs are detailed for wireless power transfer coils including advantages such …

Comparative Analysis Of Vernier Machines With Spoke, Surface Mounted, And Halbach Pm Rotors For In-Wheel Traction, Ali Mohammadi, Aaron M. Cramer, Dan M. Ionel

Electrical and Computer Engineering Graduate Research

Axial-flux Permanent Magnet (AFPM) machines are well-suited for in-wheel traction in electric vehicles due to their compact structure and higher torque density. This paper presents a large-scale design optimization of an axial-flux permanent magnet vernier machine (PMVM) of the MAGNUS type with a double stator configuration. The active stator features double layer wound coils, while the passive stator is unwound but has a similar profile. The reference design employs a rotor with permanent magnets (PMs) arranged in a spoke-type field intensifying pattern, providing high flux concentration. Design optimization was performed using 3-D electromagnetic Finite Element Analysis (FEA) and the Differential …

On The Optimal Design Of Coreless Afpm Machines With Halbach Array Rotors For Electric Aircraft Propulsion, Matin Vatani, Yaser Chulaee, Ali Mohammadi, David R. Stewart, John F. Eastham, Dan M. Ionel

Electrical and Computer Engineering Graduate Research

This paper presents and evaluates the optimal design of a coreless axial flux permanent magnet (AFPM) motor for electric aircraft propulsion. Ferromagnetic cores are entirely removed from the machine’s structure to improve the specific power density and efficiency. An approach for envelope design optimization of the proposed motor is introduced, considering the polarity as an independent variable and employing an evolutionary algorithm and 3D Finite Element Analysis (FEA). In addition to the proposed electric motor’s electromagnetic performance, fault-tolerant capability and thermal management are considered in the optimization procedure. The optimization results and similar studies from power electronic and thermal management …

Masthead

Missouri Law Review

No abstract provided.