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Articles 18061 - 18090 of 2913336
Full-Text Articles in Entire DC Network
Barrett’S Esophagus-Associated Genetic Loci In African Americans: A Case-Control Study Using The All Of Us Research Program, Ashwin Rao, Jinyoung Byun, Aaron P Thrift, Hashem B El-Serag
Barrett’S Esophagus-Associated Genetic Loci In African Americans: A Case-Control Study Using The All Of Us Research Program, Ashwin Rao, Jinyoung Byun, Aaron P Thrift, Hashem B El-Serag
Faculty, Staff and Students Publications
Background and aims: Barrett's esophagus is the only known precursor lesion to esophageal adenocarcinoma (EAC). Barrett's esophagus and EAC are less common in African Americans than in non-Hispanic Whites. Studies in European populations have identified Barrett's esophagus-associated risk loci; however, none have examined loci in African Americans cohorts. We conducted a case-control targeted replication study to investigate previously identified Barrett's esophagus risk loci in an African Americans cohort in the All of Us (AoU) Research Program.
Methods: We abstracted phenomic and genomic data from 108 African Americans with Barrett's esophagus and 778 African Americans controls in the AoU database. We …
Treatment Of Obsessive-Compulsive Disorder Via Mental Health Technology, Erika S Trent, Nisha Jagannathan, Eric A Storch
Treatment Of Obsessive-Compulsive Disorder Via Mental Health Technology, Erika S Trent, Nisha Jagannathan, Eric A Storch
Faculty, Staff and Students Publications
Obsessive-compulsive disorder (OCD) is a debilitating neuropsychiatric disorder that remains chronic unless intervened with evidence-based intervention. Cognitive behavioral therapy (CBT) with exposure and response prevention is the gold-standard psychological intervention for OCD, but many individuals do not receive this intervention due to barriers to accessing treatment. Mental health technology tools such as telehealth, computerized programs, internet-delivered CBT, and mobile applications have been adopted to expand the accessibility of CBT. An up-to-date summary of the evidence base of technology-mediated formats of CBT for OCD treatment is provided. Clinical benefits offered by such approaches, current limitations, and future research directions are discussed.
Rooted In Hillsboro: An Urban Tree Protection Project, Leandre Mills, Aidan Mcclinton, Aria Shopbell, Karl Coppock, Wally Mcallister
Rooted In Hillsboro: An Urban Tree Protection Project, Leandre Mills, Aidan Mcclinton, Aria Shopbell, Karl Coppock, Wally Mcallister
Master of Urban and Regional Planning Workshop Projects
The Canopi team and the City of Hillsboro Urban Forestry Program completed this project to evaluate and strengthen municipal tree protection policies. Current regulations rely heavily on tree replacement rather than retention, contributing to loss of mature canopy and reduced climate, infrastructure, and equity benefits. In many cases, mature trees removed during development or infrastructure projects are replaced with small-caliper plantings that do not provide equivalent environmental or community value for decades.
As Hillsboro grows, the city faces increasing climate pressures, including urban heat island effects, stormwater impacts, invasive pests, and uneven canopy distribution across historically underserved neighborhoods. These challenges …
Historic Parkrose: Planning For Vacant Properties, Rowan Anderson, Julia Cruz Jones, Akasha Lawrence Spence, Clara Lietz, Cal Storrs
Historic Parkrose: Planning For Vacant Properties, Rowan Anderson, Julia Cruz Jones, Akasha Lawrence Spence, Clara Lietz, Cal Storrs
Master of Urban and Regional Planning Workshop Projects
Crescent Consulting was engaged by Historic Parkrose, a Portland-based non-profit, to analyze vacant and under-utilized properties along Northeast Sandy Boulevard within the Historic Parkrose Business District. The area has been the focus of many planning efforts at the neighborhood, city, and state level that have identified community needs and priorities, yet implementation has been limited. Forthcoming Tax Increment Financing (TIF) funding may create opportunities to implement these plans and encourage reinvestment that will contribute to the corridor’s vitality and economic capacity. This report is a resource for evaluating and prioritizing vacant lot redevelopment opportunities in Parkrose, helping align future investment …
Westside Foodshed Hub Initiative: Farm-To-Food-Assistance Feasibility Study, Andrew Bugh, James Shelstad, Jordan Rasmussen, Kenton Marquigny, Reed Johnson
Westside Foodshed Hub Initiative: Farm-To-Food-Assistance Feasibility Study, Andrew Bugh, James Shelstad, Jordan Rasmussen, Kenton Marquigny, Reed Johnson
Master of Urban and Regional Planning Workshop Projects
The Westside Foodshed Planning Initiative is a feasibility study exploring how Farm-to- Food-Assistance, or F2FA, can supplement CAFE's food assistance work in Northwest and Downtown Portland. The study was conducted by Soil for Roses, a planning team consisting of members of Portland State University's Master of Urban and Regional Planning program. Through this project, Soil for Roses envisions the F2FA as a regional food aggregation and distribution hub tailored to CAFE’s goals of advancing food security and nutrition, environmental stewardship, and resilience.
Gateway: Heat Resilience Focus Area Final Report, Jill Coleman, Sletsy Dlamini, Luke Gordon, Danny Harden-Ramella, Joe Kortenhof, Devery Sheridan
Gateway: Heat Resilience Focus Area Final Report, Jill Coleman, Sletsy Dlamini, Luke Gordon, Danny Harden-Ramella, Joe Kortenhof, Devery Sheridan
Master of Urban and Regional Planning Workshop Projects
In the Summer of 2021, Multnomah County experienced a heat dome that resulted in the tragic deaths of 75 people and caused 258 individuals to seek medical care in emergency rooms and urgent care facilities. While heat related treatment had been experienced in previous heat waves, no heat related deaths had been recorded by the county prior to the Heat Dome. Since 2021, heat-related fatalities have remained elevated above the pre-2021 baseline. Medical visits for illness and injury also remain elevated from 2021 onwards. Many of the more easily implementable short-term solutions have already been implemented in Portland, and the …
C-Tran Bus Stop Accessibility Action Plan, Grace Alston, Michelle Auster, Zoe Beckley, Noah Crawford, Ryan Gallo, Angelique Wallmann
C-Tran Bus Stop Accessibility Action Plan, Grace Alston, Michelle Auster, Zoe Beckley, Noah Crawford, Ryan Gallo, Angelique Wallmann
Master of Urban and Regional Planning Workshop Projects
Project Background
C-TRAN is the regional public transportation provider for the Clark County Public Transportation Benefit Area in Southwest Washington, providing connections to the Portland, Oregon, metro region. C-TRAN connects people to opportunities, supports economic vitality, and enhances the quality of life for the community.
The challenge - 66% of C-TRAN’s bus stops are non-ADA compliant, C-TRAN’s existing capital investment strategy lacks community input and a multi-year application.
The Opportunity - Our Bus Stop Accessibility Action Plan will leverage community engagement and social metric data to develop a long-term investment strategy.
Reimagining The Cully 5 Corners, Samuel Anderson, Noah Brown, Kaitlyn Cook, Nicholas Pelster, Michael Wickham, Steven Yee
Reimagining The Cully 5 Corners, Samuel Anderson, Noah Brown, Kaitlyn Cook, Nicholas Pelster, Michael Wickham, Steven Yee
Master of Urban and Regional Planning Workshop Projects
Reimagining the Cully 5 Corners is a project spearheaded by the Cully Coalition and Confluence Planning + Design, aiming to create a vision and plan for a centralized, connected, resilient hub for this area of NE Portland, Oregon.
The Cully Coalition envisions Cully as an equitable and socially just neighborhood that enriches and uplifts all community members while minimizing displacement, improving community cohesion, and supporting economic vitality.
Like many Portland areas annexed in the late 20th century, the Cully neighborhood has experienced decades of relative underinvestment in terms of public services, urban design, and business development.
Uplifting Cully starts with …
Functional Genomics Studies Of Psychiatric Disorders In Individuals Of Latin American Populations: A Scoping Review, Luz M Porras, Isabelle Rodríguez-Lausell, Gabriel Iglesias-Maldonado, Emily Val F Tuliao, Gabriela Martínez, Chelsey Leveque, Julian Tobon, Rachel Eloy, Sintia Belangero, Cynthia M Bulik, Camila M Loureiro, Carolina Muniz Carvalho, Vanessa Ota, Diego Luiz Rovaris, Eric A Storch, Eva Maria Trujillo-Chi Vacuan, Maria M Velasquez, Latin American Genomics Consortium, Marcos L Santoro, Humberto Nicolini, Elizabeth G Atkinson, Janitza L Montalvo-Ortiz, Paola Giusti-Rodríguez
Functional Genomics Studies Of Psychiatric Disorders In Individuals Of Latin American Populations: A Scoping Review, Luz M Porras, Isabelle Rodríguez-Lausell, Gabriel Iglesias-Maldonado, Emily Val F Tuliao, Gabriela Martínez, Chelsey Leveque, Julian Tobon, Rachel Eloy, Sintia Belangero, Cynthia M Bulik, Camila M Loureiro, Carolina Muniz Carvalho, Vanessa Ota, Diego Luiz Rovaris, Eric A Storch, Eva Maria Trujillo-Chi Vacuan, Maria M Velasquez, Latin American Genomics Consortium, Marcos L Santoro, Humberto Nicolini, Elizabeth G Atkinson, Janitza L Montalvo-Ortiz, Paola Giusti-Rodríguez
Faculty, Staff and Students Publications
Over the past 15 years, genetic studies of psychiatric disorders have provided important insight into the contribution of both common variants of small effect, as well as rare exonic and copy number variants with large effect sizes. Genome-wide association studies (GWAS) allow us to understand the intricate polygenicity characteristic of many psychiatric disorders. However, a considerable proportion of single nucleotide polymorphisms (SNPs) implicated in these disorders localize to the non-coding regions of the genome. Unraveling the molecular mechanisms that underlie the etiology of psychiatric illnesses requires integration using functional genomics approaches. Functional genomics methods are critical for developing a mechanistic …
Whole Genome Sequencing Analysis Of Over 3500 Individuals Dementia-Free Over 85 Years Old, Gina M Peloso, Dongyu Wang, Sabrina M Abbruzzese, Joshua C Bis, Seung Hoan Choi, Alexa Beiser, Jan Bressler, Josée Dupuis, Alison E Fohner, Mohsen Ghanbari, Richard A Gibbs, Nancy Heard-Costa, M Arfan Ikram, Paul Lacaze, Quentin Le Grand, Oscar L Lopez, Thomas H Mosley, Moeen Riaz, Aïcha Soumaré, Amber Yaqub, Eric Boerwinkle, Bruce M Psaty, Myriam Fornage, Sudha Seshadri, Anita L Destefano
Whole Genome Sequencing Analysis Of Over 3500 Individuals Dementia-Free Over 85 Years Old, Gina M Peloso, Dongyu Wang, Sabrina M Abbruzzese, Joshua C Bis, Seung Hoan Choi, Alexa Beiser, Jan Bressler, Josée Dupuis, Alison E Fohner, Mohsen Ghanbari, Richard A Gibbs, Nancy Heard-Costa, M Arfan Ikram, Paul Lacaze, Quentin Le Grand, Oscar L Lopez, Thomas H Mosley, Moeen Riaz, Aïcha Soumaré, Amber Yaqub, Eric Boerwinkle, Bruce M Psaty, Myriam Fornage, Sudha Seshadri, Anita L Destefano
Faculty, Staff and Students Publications
BACKGROUND:
Identifying genetic variants conferring resilience to Alzheimer’s disease and related dementia (ADRD) may hold promise for developing therapeutics.
OBJECTIVE:
To determine genetic associations with being dementia-free at age 85 (DF85).
METHODS:
We examined genetic associations, using whole genome sequencing data, with DF85 in three Trans-Omics for Precision Medicine cohorts and the Alzheimer’s Disease Sequencing Project Phenotype Harmonization Consortium. We tested common variants individually and aggregation of rare (MAF≤1%) coding and non-coding variants in DF85 participants (n=3,657) against individuals who were not DF85 (n=20,010). We verified associations using a stricter control set who developed dementia before age 85 (n=5,552).
RESULTS: …
Disease-Specific Growth Charts Capture Characteristic Growth Patterns In Children With Pmm2 – Cdg, Kyriakie Sarafoglou, Christina Lam, Andrew C Edmondson, Andrea Miller, Rodrigo T Starosta, Aziza Zeighami, Seishu Horikoshi, Hayden Vreugdenhil, Fernando Scaglia, Tamas Kozicz, Queenie K G Tan, Bradley S Miller, Iván Martínez-Duncker, Gerard T Berry, Peter Mcwilliams, Eva Morava, Yaw Addo
Disease-Specific Growth Charts Capture Characteristic Growth Patterns In Children With Pmm2 – Cdg, Kyriakie Sarafoglou, Christina Lam, Andrew C Edmondson, Andrea Miller, Rodrigo T Starosta, Aziza Zeighami, Seishu Horikoshi, Hayden Vreugdenhil, Fernando Scaglia, Tamas Kozicz, Queenie K G Tan, Bradley S Miller, Iván Martínez-Duncker, Gerard T Berry, Peter Mcwilliams, Eva Morava, Yaw Addo
Faculty, Staff and Students Publications
Background: Growth faltering is prevalent in 96% of children with Phosphomannomutase-2 congenital disorder of glycosylation (PMM2-CDG). Published long-term growth data is extremely limited. Growth and weight patterns of PMM2-CDG children differ from the general population limiting the utility of existing normative growth charts to track development trajectory in comparison to peers with PMM2-CDG.
Objective: Create PMM2-CDG disease-specific height-, weight-, and BMI-for-age reference growth charts (0-20 years).
Methods: De-identified growth data was provided by Frontiers in Congenital Disorders of Glycosylation Consortium, CDG Care, Minnesota Partnership for Biotechnology and Medical Genomics, and Glycomine, Inc. Semi-parametric modeling techniques were used to develop PMM2-CDG-specific …
Transient Yap Activation Uncovers The Neurogenic Potential Of Proliferative Mammalian Müller Glia, English J Laserna, Irina V Saltykova, Benjamin M Hall, Xuefei Tong, Justin S Dhindsa, Borna Sarker, Ayrea E Hurley, Paul G Swinton, William R Lagor, Nicholas M Tran, James F Martin, Ross A Poché
Transient Yap Activation Uncovers The Neurogenic Potential Of Proliferative Mammalian Müller Glia, English J Laserna, Irina V Saltykova, Benjamin M Hall, Xuefei Tong, Justin S Dhindsa, Borna Sarker, Ayrea E Hurley, Paul G Swinton, William R Lagor, Nicholas M Tran, James F Martin, Ross A Poché
Faculty, Staff and Students Publications
The Hippo pathway effector YAP promotes spontaneous proliferation of Müller glia (MG), suggesting that bypassing Hippo signaling and activating YAP could enhance retinal regeneration. However, whether proliferative adult MGs retain meaningful neurogenic competence remains unclear. Here, using viral delivery of a Hippo-resistant YAP variant to wild-type adult MGs, we achieved transient YAP activation in adult MGs, inducing proliferation followed by cell-cycle withdrawal and differentiation. Intersectional genetic lineage tracing and EdU labeling, combined with transcriptomic analyses, revealed that YAP-activated MGs predominantly regenerate MGs, whereas only a subset gives rise to bipolar cell-like neurons. These results indicate that proliferative MGs acquire a …
Plasticity And Language In The Anaesthetized Human Hippocampus, Kalman A Katlowitz, Eric R Cole, Elizabeth A Mickiewicz, Shraddha Shah, Melissa Franch, Joshua A Adkinson, James L Belanger, Raissa K Mathura, Domokos Meszéna, Matthew Mcginley, William Muñoz, Garrett P Banks, Sydney S Cash, Chih-Wei Hsu, Angelique C Paulk, Nicole R Provenza, Andrew J Watrous, Ziv Williams, Alica M Goldman, Vaishnav Krishnan, Atul Maheshwari, Sarah R Heilbronner, Robert Kim, Nuttida Rungratsameetaweemana, Benjamin Y Hayden, Sameer A Sheth
Plasticity And Language In The Anaesthetized Human Hippocampus, Kalman A Katlowitz, Eric R Cole, Elizabeth A Mickiewicz, Shraddha Shah, Melissa Franch, Joshua A Adkinson, James L Belanger, Raissa K Mathura, Domokos Meszéna, Matthew Mcginley, William Muñoz, Garrett P Banks, Sydney S Cash, Chih-Wei Hsu, Angelique C Paulk, Nicole R Provenza, Andrew J Watrous, Ziv Williams, Alica M Goldman, Vaishnav Krishnan, Atul Maheshwari, Sarah R Heilbronner, Robert Kim, Nuttida Rungratsameetaweemana, Benjamin Y Hayden, Sameer A Sheth
Faculty, Staff and Students Publications
Consciousness is a fundamental component of cognition1, but the degree to which higher-order pattern recognition relies on it remains disputed2,3. Here we demonstrate the persistence of oddball discrimination, semantic processing and online prediction in individuals under general-anaesthesia-induced loss of consciousness4,5. Using high-density Neuropixels microelectrodes6 to record both single-unit and local-field-potential neural activity in the human hippocampus while playing a series of tones to anaesthetized patients, we found that hippocampal neurons and local oscillations retained some detection of oddball tones. This effect size grew over the course of the experiment …
Application Of Information Literacy Skills To Everyday Life Information Seeking In College Students: Implications For Instruction, Stephanie Ward, Rachel Dineen, Darren Ilett
Application Of Information Literacy Skills To Everyday Life Information Seeking In College Students: Implications For Instruction, Stephanie Ward, Rachel Dineen, Darren Ilett
Communications in Information Literacy
Academic librarians who teach information literacy (IL) skills hope students will transfer those skills to their information seeking in everyday life. However, there is little evidence that students are transferring what they learn about research to their lives outside college. This study aims to find out what search and evaluation strategies college students who have had IL instruction apply to their own personal information seeking behaviors. To do this, a talk-aloud protocol was used to record participants’ thoughts and actions as they navigated scenarios that required them to select a source that met a non-academic information need. The findings indicate …
The Spectrum Of Authority: A New Approach To Teaching Ai And Primary Source Literacies, Kristen Howard
The Spectrum Of Authority: A New Approach To Teaching Ai And Primary Source Literacies, Kristen Howard
Communications in Information Literacy
This article presents an information literacy workshop designed for undergraduate history courses that introduces students to generative artificial intelligence (GenAI) while strengthening primary source literacy. Anchored in the Association of College and Research Libraries (ACRL) Framework for Information Literacy for Higher Education, “Authority Is Constructed and Contextual,” the workshop employs an innovative pedagogical device, the Spectrum of Authority, to help students critically evaluate information sources. Through comparative analysis and guided discussion, students increased their ability to assess credibility in information sources. Student feedback indicated increased confidence in analyzing primary sources and a greater understanding of GenAI’s capabilities and …
Critical Information Literacy In Higher Education: An Evolution In Theory, Practice, And Assessment, Dan Williford
Critical Information Literacy In Higher Education: An Evolution In Theory, Practice, And Assessment, Dan Williford
Communications in Information Literacy
This article offers a critical synthesis of scholarship on critical information literacy (CIL) in higher education from 2015 to 2026, extending and recalibrating prior longitudinal reviews to account for post-2020 theoretical, political, and technological shifts. Drawing on a corpus of 48 peer-reviewed publications published between 2020 and 2026, the study employs thematic cluster analysis—building on Tewell’s four-domain framework—to examine developments in theory, pedagogy, digital and political engagement, reflexive critique, and assessment. Rather than treating critical information literacy as a settled framework, this review positions it as an evolving and contested practice shaped by the political economy of higher education. It …
"An Open Mind And A Critical Stance": A Content Analysis Of Information Literacy Integration Into A Course About Poverty And Discrimination, Ashley Shealy, C. Rebecca Oldham, Clay Oldham, Tara L. Griffith
"An Open Mind And A Critical Stance": A Content Analysis Of Information Literacy Integration Into A Course About Poverty And Discrimination, Ashley Shealy, C. Rebecca Oldham, Clay Oldham, Tara L. Griffith
Communications in Information Literacy
The ACRL Framework argues that infusing curriculum with information literacy concepts can improve students’ attitudes and abilities to navigate complex information landscapes. This paper describes how a librarian and a faculty member integrated an information literacy curriculum into an undergraduate upper-division course about poverty and discrimination. Curriculum efficacy was assessed through directed content analysis of student responses to open-ended questions about engaging with news and social media, forming opinions, and having conversations about controversial topics. Responses were analyzed using a coding scheme based on course objectives derived from Framework dispositions and knowledge practices. Results indicated that exposing students to an …
Paid Employment And Ability To Work Among People Receiving Dialysis: A Systematic Review Of Qualitative Studies, Ao Zhang, Adam Martin, Karine Manera, Chandana Guha, Martin Howell, Patrizia Natale, Nicole Scholes-Robertson, Dharshana Sabanayagam, Adeera Levin, Wolfgang Winkelmayer, Kevin F Erickson, Germaine Wong, Allison Jaure, Anita Van Zwieten
Paid Employment And Ability To Work Among People Receiving Dialysis: A Systematic Review Of Qualitative Studies, Ao Zhang, Adam Martin, Karine Manera, Chandana Guha, Martin Howell, Patrizia Natale, Nicole Scholes-Robertson, Dharshana Sabanayagam, Adeera Levin, Wolfgang Winkelmayer, Kevin F Erickson, Germaine Wong, Allison Jaure, Anita Van Zwieten
Faculty, Staff and Students Publications
Rationale & objective: People receiving dialysis have reduced workforce participation, which can affect mental well-being and exacerbate the financial burden of dialysis. This study describes the experiences and perspectives of people receiving dialysis on employment and their ability to work.
Study design: Systematic review and thematic synthesis of qualitative studies.
Setting & study populations: Adults aged 16 years and over receiving dialysis.
Search strategy & sources: MEDLINE, Embase, and PsycINFO were searched to May 2025 for qualitative and mixed-methods studies that reported the perspectives of people receiving dialysis on employment or ability to work.
Data extraction: Text from results and …
Spatial Transcriptomics Reveals Coordinated Endothelial And Epithelial Activator Protein-1 Activation In Chronic Lung Allograft Dysfunction, Yasufumi Goda, Tatsuhiko Naito, Mudassir M Banday, Andrew S Potter, Igor Odintsov, Kapil Patel, Nicole Davis, Stefi Lee, Amit Gaggar, Ivan Rosas, Gabriel Loor, Don Hayes, Nirmal S Sharma
Spatial Transcriptomics Reveals Coordinated Endothelial And Epithelial Activator Protein-1 Activation In Chronic Lung Allograft Dysfunction, Yasufumi Goda, Tatsuhiko Naito, Mudassir M Banday, Andrew S Potter, Igor Odintsov, Kapil Patel, Nicole Davis, Stefi Lee, Amit Gaggar, Ivan Rosas, Gabriel Loor, Don Hayes, Nirmal S Sharma
Faculty, Staff and Students Publications
Chronic lung allograft dysfunction (CLAD) limits long-term lung graft survival, yet its specific gene expression profiles remain unclear. We performed comprehensive spatial transcriptomic analyses of human lungs from CLAD patients, non-CLAD transplant recipients, and non-transplanted controls. In CLAD, AP-1 target genes, including JUNB and FOS, were significantly upregulated in both the epithelium and endothelium, whereas anti-fibrotic genes such as A2M and surfactant proteins (SFTPA1,2) were upregulated in non-CLAD. The lymphocyte population in CLAD was predominantly composed of T cells, with elevated JAK3-IL7R signaling. TNF and IL-17 signaling pathways were commonly activated in both the epithelium and endothelium, with JUNB and …
Generation And Characterization Of Twist1 Acetyl-Mimic And Acetyl-Deficient Mouse Models, Mary Elmeniawi, Xiaobin Yu, Samuel Wen, Gunjan A Bhatia, Lan Liao, Jianming Xu, Walid D Fakhouri
Generation And Characterization Of Twist1 Acetyl-Mimic And Acetyl-Deficient Mouse Models, Mary Elmeniawi, Xiaobin Yu, Samuel Wen, Gunjan A Bhatia, Lan Liao, Jianming Xu, Walid D Fakhouri
Faculty, Staff and Students Publications
TWIST1 encodes a highly conserved basic helix–loop–helix transcription factor essential for embryonic development from Drosophila to humans. TWIST1 activity is regulated by post‐translational modifications, including phosphorylation during development and cancer metastasis. Recent cancer studies identified acetylation of lysines K73 and K76 as a novel regulatory modification that shifts TWIST1 from a repressive to an activating state during epithelial‐to‐mesenchymal transition (EMT). However, the developmental and in vivo functions of TWIST1 acetylation remain unknown. To investigate the physiological role, we generated the first acetyl‐deficient Twist1 K73,76R K73,76R and acetyl‐mimic Twist1 K73,76Q K73,76Q mouse models using CRISPR/Cas9‐mediated genome editing. Targeted sequencing confirmed substitutions, …
Curriculum Innovation: Neurocritical Care Eeg Rounds: A Model To Improve Neurology Resident Eeg Interpretation., Ellen Sylvie Sanchez Mas, Mitchell Lloyd Powell, Marco Malaga, Corey Elam Goldsmith, Rahul Damani, Lu Lin
Curriculum Innovation: Neurocritical Care Eeg Rounds: A Model To Improve Neurology Resident Eeg Interpretation., Ellen Sylvie Sanchez Mas, Mitchell Lloyd Powell, Marco Malaga, Corey Elam Goldsmith, Rahul Damani, Lu Lin
Faculty, Staff and Students Publications
Background and purpose: Rural-urban disparities in neurological care have been well documented, but limited data exist regarding Guillain-Barré Syndrome (GBS). This study examines differences in patient demographics, hospital characteristics, and outcomes among GBS admissions to rural versus urban hospitals in the United States.
Methods: Using the 2021 National Inpatient Sample, we conducted a retrospective cohort study of adult hospitalizations with a principal diagnosis of GBS. Hospitals were classified as rural or urban based on U.S. census designations. Multivariate logistic and linear regression models were used to assess associations between hospital location and outcomes, adjusting for demographic, clinical, and hospital-level factors. …
Hematologic Markers And Machine Learning In Predicting Placenta Accreta: A Case-Control Study, Michael D Jochum, Kelly D Albrecht, Yamely Mendez Martinez, Victoria Zhang, Sanmay Sarada, Brian Burnett, Christina C Reed, Karin A Fox, Amir A Shamshirsaz, Michael A Belfort, Jessian L Munoz, Hennie A Lombaard
Hematologic Markers And Machine Learning In Predicting Placenta Accreta: A Case-Control Study, Michael D Jochum, Kelly D Albrecht, Yamely Mendez Martinez, Victoria Zhang, Sanmay Sarada, Brian Burnett, Christina C Reed, Karin A Fox, Amir A Shamshirsaz, Michael A Belfort, Jessian L Munoz, Hennie A Lombaard
Faculty, Staff and Students Publications
Objective: This study aims to enhance antenatal detection of placenta accreta spectrum (PAS) and predict severe hemorrhage at delivery using machine learning by evaluating the association between antenatal hematologic index trends across trimesters, imaging markers, and patient history.
Methods: We retrospectively analyzed 2017-2023 data from a PAS referral center, including demographics, laboratory results, ultrasounds, and outcomes. Patients with confirmed PAS (cases) were compared to those with antenatal risk but no histopathologic evidence of PAS (controls). Statistical analyses and machine learning models were developed to predict PAS. We also used machine learning to predict severe hemorrhage (>1500 mL) in the …
Anterior Cutaneous Nerve Entrapment Syndrome From Glucagon-Like Peptide-1 Receptor Agonist Injection, Neha Singh, Elisa Chaparro, Jordan Michael Shapiro, Emanuel Narcis Husu
Anterior Cutaneous Nerve Entrapment Syndrome From Glucagon-Like Peptide-1 Receptor Agonist Injection, Neha Singh, Elisa Chaparro, Jordan Michael Shapiro, Emanuel Narcis Husu
Faculty, Staff and Students Publications
Anterior cutaneous nerve entrapment syndrome (ACNES) is an underdiagnosed cause of abdominal pain. We report the first documented ACNES case following subcutaneous administration of glucagon-like peptide-1 receptor agonist. A 44-year-old man developed focal, neuropathic abdominal pain coinciding with initiation of tirzepatide injections. Clinical examination confirmed ACNES diagnosis, and pain improved after relocating injections away from the abdomen and initiating multimodal pharmacotherapy. This case emphasizes the need to consider ACNES in patients endorsing focal abdominal pain with concurrent use of glucagon-like peptide-1 therapy and highlights injection site modification as a simple, effective management strategy while exercising self-restraint with respect to workup.
Perception Of Dynamic Lighting: Chromatic Adaptation And Augmented Reality, Abigayle Weymouth
Perception Of Dynamic Lighting: Chromatic Adaptation And Augmented Reality, Abigayle Weymouth
Theses
Augmented reality (AR) is a rapidly developing technology with use cases ranging everywhere from medicine to entertainment. This research focuses on optical see-through (OST) AR, one of the common overarching types of available augmented reality devices. Color appearance in OST AR systems is affected by a mix of the viewing conditions and environment of the real world and the transparent virtual elements. Accurate control of the color of AR content in real-world use cases, which often includes changes in color over time in both parts of the environment, is important for many applications. This dissertation includes three studies of color …
Ultra Fast Calorimeter Simulation With Generative Machine Learning On Fpgas, P. Alex May, Qibin Liu, Julia Gonski, Benjamin Nachman
Ultra Fast Calorimeter Simulation With Generative Machine Learning On Fpgas, P. Alex May, Qibin Liu, Julia Gonski, Benjamin Nachman
Faculty Research, Scholarly, and Creative Activity
Computationally expensive, high-accuracy detector simulations are a major bottleneck for many particle physics experiments such as those at the Large Hadron Collider (LHC) as well as those planned for future colliders. This challenge has motivated the development of fast generative machine learning based surrogates. We present a hardware-aware variational autoencoder model for fast calorimeter simulation that is designed specifically for field programmable gate array (FPGA) deployment, offering faster and lower power inference capability. Quantization aware training and other compression techniques are applied to respect the resource constraints of a single FPGA. The synthesized implementation of the VAE decoder achieves sub-millisecond …
Systematic Identification Of Cell-Cell Interactions Associated With The Severity Of Patients With Alzheimer’S Disease, Zijian Zhang, Naail Chowdhury, Jing Dong, Lang Wu, Chao Cheng
Systematic Identification Of Cell-Cell Interactions Associated With The Severity Of Patients With Alzheimer’S Disease, Zijian Zhang, Naail Chowdhury, Jing Dong, Lang Wu, Chao Cheng
Faculty, Staff and Students Publications
Background
Alzheimer's disease (AD) is a complex, multifactorial neurodegenerative disorder involving dysfunction across multiple brain regions. While accumulating evidence has implicated the roles of diverse cell types, including neurons, glia, and vascular cells in AD pathogenesis, it is still poorly understood how cell type interactions drive or respond to the disease progression and severity.
Objective
This study aimed to systematically characterize cell-type–specific alterations and intercellular communication changes associated with AD progression.
Methods
We leveraged the transcriptome profiling and a previously established statistical framework to present a comprehensive mapping of the cellular interaction landscape in the human brain of AD.
Results …
Interrupted By Design: The Impact Of Push Notifications On Stress And Task Performance, Mia Hohmann
Interrupted By Design: The Impact Of Push Notifications On Stress And Task Performance, Mia Hohmann
University Honors Theses
As digital communication becomes unavoidable at work, notifications have become one of the most common and overlooked sources of interruption. Drawing from current technostress literature, this study investigates how notifications impact acute and perceived stress as well as task speed and accuracy. In an experimental setting, employed university students (N = 35) completed a data-entry task while receiving either no notifications, task-relevant notifications or task-irrelevant notifications to examine how different types of digital interruptions influenced stress and performance. Stress was measured through a pre- and post-task survey and performance was assessed through both speed and accuracy. Although results showed significant …
The Dolor: How A Generation Of Women Quietly Lost Their Children, Alexis Mclean
The Dolor: How A Generation Of Women Quietly Lost Their Children, Alexis Mclean
University Honors Theses
This thesis is an exploration of the phenomenon of increased adoption rates between the years of 1945 and 1973 and attempts to establish a cohesive explanation for and image of the experience of these birth mothers. My research found that adoptions during this time period are generally characterized by the utilization of maternity homes, coercion, and secrecy. The typical birth mother during this time was white and middle class, emblematic of the motivations of their adoptions: to maintain an idealist image of their motherhood and maintain socioeconomic status. Despite this position framed by privilege, these women too often report having …
Birth Satisfaction, As Measured By The Birth Satisfaction Scale–Revised (Bss-R), And Its Role In Predicting Breastfeeding Duration, Maternal-Infant Attachment, And Postpartum Depression, Molly Parker
University Honors Theses
Birth satisfaction has been consistently associated with improved maternal outcomes such as reduced postpartum depression (PPD), stronger maternal-infant attachment, and longer breastfeeding duration. However, the extent to which birth satisfaction independently predicts these outcomes remains unclear. This study examined whether birth satisfaction, as measured by the Birth Satisfaction Scale–Revised (BSS-R), predicts postpartum depression, maternal-infant attachment, and breastfeeding duration in a longitudinal cohort.
Data were drawn from the Prenatal Environmental And Child Health (PEACH) study. Birth satisfaction was assessed at 12 months postpartum using the BSS-R. Postpartum depression was measured using the Edinburgh Postnatal Depression Scale (EPDS), maternal-infant attachment using the …
Social Determinants As A Predictor For Heart Disease Mortality: Oregon Regional Study, Jewel Jones
Social Determinants As A Predictor For Heart Disease Mortality: Oregon Regional Study, Jewel Jones
University Honors Theses
The study examined the association between selected social determinants of health and heart disease mortality across geographic regions in Oregon. Using a regional analysis design, county-level population and mortality data were grouped into nine geographic regions to evaluate patterns of cardiovascular disease burden across the state. Social determinant variables were obtained from publicly available U.S. Census Bureau datasets and included poverty, crowding among households, single-parent households, lack of broadband internet subscription, housing cost burden, high school diploma attainment, and unemployment.
Heart disease mortality counts per 100,000 population were derived from official birth and death certificate records. Statistical analyses were conducted …