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Past Present, & Future: Bushwick Inlet Redevelopment, Aaryan Nair Jun 2026

Past Present, & Future: Bushwick Inlet Redevelopment, Aaryan Nair

Publications and Research

This report examines how ecosystem structure, hydrology, and material flows in Williamsburg, Brooklyn have changed from pre-colonial conditions to the present and how they are expected to evolve under future climate change. Prior to European colonization, the landscape functioned as a forest–wetland mosaic with high infiltration capacity, slow water movement, and strong nutrient retention. These conditions supported stable aquatic ecosystems and minimized pollutant transport to the East River.

Modern urbanization has fundamentally altered this system. Impervious surfaces and engineered drainage systems have shifted hydrology from infiltration-dominated to runoff-dominated pathways, producing rapid “flashy” flows and reducing water residence time.

Storm events …


Placenta Accreta Spectrum Risk In Endometriosis: A Retrospective Cohort Study With Art Subanalysis, Madeline West, Amir Alsaidi, Michael A Belfort, Hendrik A Lombaard, Yamely H Mendez, Christina C Reed, Amir A Shamshirsaz, Jessian L Munoz Jun 2026

Placenta Accreta Spectrum Risk In Endometriosis: A Retrospective Cohort Study With Art Subanalysis, Madeline West, Amir Alsaidi, Michael A Belfort, Hendrik A Lombaard, Yamely H Mendez, Christina C Reed, Amir A Shamshirsaz, Jessian L Munoz

Faculty, Staff and Students Publications

No abstract provided.


Detection, Persistence, And Rising Prevalence Of Oncogenic Viruses Revealed By Wastewater Metagenomics, Harihara Prakash, Ryan K Perez, Matt Ross, Michael Tisza, Sara J Javornik Cregeen, Jennifer Deegan, Joseph F Petrosino, Eric Boerwinkle, Justin R Clark, Anthony W Maresso Jun 2026

Detection, Persistence, And Rising Prevalence Of Oncogenic Viruses Revealed By Wastewater Metagenomics, Harihara Prakash, Ryan K Perez, Matt Ross, Michael Tisza, Sara J Javornik Cregeen, Jennifer Deegan, Joseph F Petrosino, Eric Boerwinkle, Justin R Clark, Anthony W Maresso

Faculty, Staff and Students Publications

Oncogenic viruses cause high-risk cancers in humans and are responsible for nearly 20% of all cancer cases worldwide. Currently, very limited data exist in the realm of wastewater-based viral epidemiology (WBE) for cancer-causing viruses, with existing studies using targeted approaches (i.e., PCR-based approaches) that lack genomic resolution. In this study, we used a hybrid-capture approach to detect, filter, and sequence all known oncogenic virus signals from wastewater samples collected over 3 years (May 2022-May 2025) in 16 Texas cities, covering nearly 25% of the state's population. Once sequenced, we used custom computational tools designed for wastewater metagenomics to assign reads …


Recommendations For Advancing Elementary Music Education For Students With Disabilities In Skyline Ridge School District, Dawn Marie Schafer Jun 2026

Recommendations For Advancing Elementary Music Education For Students With Disabilities In Skyline Ridge School District, Dawn Marie Schafer

Doctoral Dissertations and Projects

The purpose of this applied research study was to provide recommendations to advance music instruction to students with disabilities at sixteen elementary schools in the Skyline Ridge School District (SRSD). The problem was that there was evidence of low musicianship and music participation in students with disabilities in the middle schools in SRSD. The rationale for this study was that students with disabilities may be capable of achieving musicianship as well as any other student. For this reason, music educators must be prepared to set them up for success. The central research question was: How can the elementary music teachers …


Exploring Teacher Experiences And Readiness In Supporting Twice-Exceptional Students: A Transcendental Phenomenological Study, Jennifer D B Melvin Jun 2026

Exploring Teacher Experiences And Readiness In Supporting Twice-Exceptional Students: A Transcendental Phenomenological Study, Jennifer D B Melvin

Doctoral Dissertations and Projects

The purpose of this transcendental phenomenological study was to describe the perceived preparedness for the responsibility for the educational experiences of twice-exceptional students at public schools in Western Georgia. Twice-exceptional students, who are gifted and have disabilities, face unique challenges in academic achievement and social-emotional well-being due to asynchronous profiles and unmet needs. While evidence-based strategies exist to support twice-exceptional learners, appropriate training for teachers is imperative to ensure these approaches are implemented effectively. The theory guiding this study was Bandura’s social cognitive theory, as it posits that there is a connection between personal factors, behavioral patterns, and the environment …


Destined To Fail?: The U.S. Advisory Period And The Lost Path To Victory, 1960-1965, Alexander Patrick Fancher Jun 2026

Destined To Fail?: The U.S. Advisory Period And The Lost Path To Victory, 1960-1965, Alexander Patrick Fancher

Doctoral Dissertations and Projects

South Vietnam experienced robust military and economic development between 1960 and 1963 under the leadership of President Ngo Dinh Diem. With the help of U.S. aid, the RVNAF improved its ability to wage war against the Viet Cong, while simultaneously pacifying the countryside. ARVN and VNN units developed new capabilities and trained officers to replace losses after the French Exodus from Vietnam. The introduction of U.S. advisors created the conditions necessary for the development of a young, inexperienced military. Acting as guides, these Americans were cautiously optimistic that South Vietnam was on the path to self-sufficiency by spring 1963 as …


A Phenomenological Study Of Binge Eating Disorder And Trauma In Black Women Managed By Religious Coping, Nicole Rae Skinner Jun 2026

A Phenomenological Study Of Binge Eating Disorder And Trauma In Black Women Managed By Religious Coping, Nicole Rae Skinner

Doctoral Dissertations and Projects

The purpose of this phenomenological study was to understand the relationship between trauma, binge eating disorder (BED) and religious coping among Black women in America. Black women are faced with stereotypes such that they are expected to be strong, resulting in avoidance behaviors related to emotions. Core to the issue of BED is an inability to manage difficult emotions in a healthy manner, thus leading to the negative pattern of bingeing. Therefore, guiding this research were two key theories: Gross’s emotional regulation theory and Pargament’s theory of religious coping. The emotional regulation theory addresses how emotions are experienced and an …


Teachers' Lived Experiences Supporting Students' Executive Functioning Skills: A Phenomenology, Mary Clare Fallon Beamer Jun 2026

Teachers' Lived Experiences Supporting Students' Executive Functioning Skills: A Phenomenology, Mary Clare Fallon Beamer

Doctoral Dissertations and Projects

The purpose of this hermeneutic phenomenological study was to understand the lived experiences of supporting students' executive functioning skills for experienced teachers at schools in Ohio. Cognitive load theory, acknowledging the relationship between executive functioning and cognition, was used to guide the study. Under this theory, human beings have a flexible yet finite ability to acquire knowledge, which is mediated through components of executive functioning, including working memory, inhibitory control, and self-regulation. Weaknesses in executive functioning may restrict cognitive load capacity through interference in the systems responsible for memory, attention, and behavior. Therefore, the following serves as the central research …


Fentanyl At The Border: A Critical Analysis Of U.S. Customs And Border Protection Strategies Against Synthetic Opioid Smuggling, Patricia Salinas Jun 2026

Fentanyl At The Border: A Critical Analysis Of U.S. Customs And Border Protection Strategies Against Synthetic Opioid Smuggling, Patricia Salinas

Doctoral Dissertations and Projects

This dissertation will investigate the efficacy of tactics employed by U.S. Customs and Border Protection (CBP) in detecting and intercepting fentanyl at legal ports of entry along the U.S border during the fiscal years 2022 to 2025. Given that fentanyl continues to be a pivotal element in the ongoing opioid crisis within the United States, it is imperative to understand the mechanisms by which this synthetic opioid is smuggled into the country and to evaluate the efficacy of federal initiatives. These efforts are crucial for protecting public health and enhancing national security. This quantitative study examines fentanyl seizure data from …


Internships As A High-Impact Practice: A Phenomenological Study Of Hbcu Student Experiences With Soft Skills, Michelle Bennett Simmons Jun 2026

Internships As A High-Impact Practice: A Phenomenological Study Of Hbcu Student Experiences With Soft Skills, Michelle Bennett Simmons

Doctoral Dissertations and Projects

The purpose of this transcendental phenomenological study was to describe soft skill development gains through high-impact practice internship experiences for Black students at an HBCU in the Mid-Atlantic United States. The theory presented informed and supported the focus of inquiry was Kolb’s experiential learning theory. This theory served as the theoretical framework for the study to answer the following central research question: What are the lived experiences of HBCU Alpha University students who participate in HIP internships? Participants included 10 Black students at Alpha University who completed an internship. The participants were selected using purposeful sampling. Data was collected through …


Voices From The Pacific: A Transcendental Phenomenological Study Of Paraprofessionals’ Experiences Using Aac Devices To Support Students With Autism In The Northern Mariana Islands, Edieson Louie Bastareche Aguirre Jun 2026

Voices From The Pacific: A Transcendental Phenomenological Study Of Paraprofessionals’ Experiences Using Aac Devices To Support Students With Autism In The Northern Mariana Islands, Edieson Louie Bastareche Aguirre

Doctoral Dissertations and Projects

The purpose of this transcendental phenomenological study was to understand the lived experiences of paraprofessionals using augmentative and alternative communication (AAC) devices to support students with autism in K–12 schools within the Commonwealth of the Northern Mariana Islands (CNMI). Grounded in Vygotsky’s sociocultural theory, the study examined paraprofessionals’ perceptions, challenges, and adaptive strategies in AAC implementation. The central research question was: What are the lived experiences of paraprofessionals implementing AAC devices to support students with autism in the Northern Mariana Islands? A transcendental phenomenological design was employed, using convenience and maximum variation sampling, to recruit 10 paraprofessionals across the CNMI. …


Lived Experiences Of Polysubstance Use And Co-Occurring Mental Health Disorders: A Phenomenological Inquiry, Candee Dione Rillon Jun 2026

Lived Experiences Of Polysubstance Use And Co-Occurring Mental Health Disorders: A Phenomenological Inquiry, Candee Dione Rillon

Doctoral Dissertations and Projects

This phenomenological study explored the lived experiences of individuals with co-occurring substance use disorders (SUD) and mental health disorders (MHD), with particular attention to the transition into polysubstance use. The purpose of the study was to understand how individuals experience and make meaning of these co-occurring conditions and the factors influencing substance use patterns. Data were collected through semi-structured interviews with participants who reported both mental health challenges and substance use histories. Thematic analysis revealed that participants experienced SUD and MHD as deeply interconnected and mutually reinforcing, often functioning within a cyclical pattern of distress and temporary relief. Substance use …


Missional Hermeneutics And The Lukan Version Of The Great Commission (Luke 24:44-49): The Dual Hermeneutical Key, Israel Martin Lemos Jun 2026

Missional Hermeneutics And The Lukan Version Of The Great Commission (Luke 24:44-49): The Dual Hermeneutical Key, Israel Martin Lemos

Doctoral Dissertations and Projects

This dissertation examines the relationship between Christological fulfillment and the mission of God within the framework of biblical interpretation, with special emphasis on Luke 24:44-49. In recent decades, missional hermeneutics has moved from the margins of theological discussion to a more visible place within biblical studies, although the field remains conceptually diverse and methodologically underdefined. On one hand, a growing body of scholarship has argued that Scripture must be read within the horizons of the missio Dei, understood as God's redemptive purpose for creation and the nations. On the other hand, mainstream biblical scholarship has often continued to privilege either …


The Impact Of Leadership Style On Cohesion And Trust Within Remote Teams, Grace E. Choi Jun 2026

The Impact Of Leadership Style On Cohesion And Trust Within Remote Teams, Grace E. Choi

Doctoral Dissertations and Projects

This qualitative phenomenological study explored how leadership approaches affected the development of trust and team cohesion within remote teams in the post-pandemic workplace. The pandemic transformed daily work interactions so that relationship focused leadership has become essential for distributed employees. This study examined how employees experience leader behaviors that either supported or hindered unity and trust through the lens of Leader-Member Exchange and transformational/transactional leadership theories. Through purposive sampling, nine adults who have spent at least one year working remotely in team-based roles in the United States were recruited for semi-structured interviews lasting approximately 45-60 minutes. Interviews were audio recorded …


The Effects Of Miscarriage On African American Men, Serita E. Baysmore Jun 2026

The Effects Of Miscarriage On African American Men, Serita E. Baysmore

Doctoral Dissertations and Projects

The purpose of this descriptive phenomenological study was to describe the lived experience of African American men who have endured the loss of a child through miscarriage. Schlossberg’s transition theory, developed in 1981, was used to identify how men work through their grief by focusing on how they enter into, move through, and move out of the transition. By centering the descriptions on lived experiences, semi-structured interviews were utilized with African American men from a North Texas church, which boasts a predominantly African American population, and by word of mouth. After completion of the interviews, the data were analyzed according …


Special Education Teachers’ Experiences And Knowledge Regarding Individuals With Severe And Profound Disabilities: A Qualitative Study, Nicole Valentine-Sokolowski Jun 2026

Special Education Teachers’ Experiences And Knowledge Regarding Individuals With Severe And Profound Disabilities: A Qualitative Study, Nicole Valentine-Sokolowski

Doctoral Dissertations and Projects

The purpose of this phenomenological study was to explore the lived experiences of special education teachers regarding their knowledge and experiences in teaching students with severe and profound disabilities during their pre-service special education teacher training. The problem is many students with severe and profound disabilities are not receiving appropriate services or instruction, which is affected by how special education teacher training programs are preparing future teachers. The theory guiding this study was John Dewey’s theory of experience, which emphasizes the importance of gaining experience to succeed. The central research question is: How prepared did special education teachers feel regarding …


From Seed To Vine Intergenerational Discipleship Model For San Antonio Heights Community Church, Alyssa Smedley Jun 2026

From Seed To Vine Intergenerational Discipleship Model For San Antonio Heights Community Church, Alyssa Smedley

Doctoral Dissertations and Projects

This project addressed the lack of an intentional intergenerational discipleship model at San Antonio Heights Community Church through the development of the From Seed to Vine ministry initiative. The project focused on cultivating a sustainable disciple-making culture rooted in relational discipleship, spiritual formation, and intentional mentorship across generations. Four micro-projects were implemented to support this vision: the Ministry Development Plan (MDP), Blogging, Advertisement of Ministry Launch, and Podcasting.

Each micro-project contributed to building awareness, fostering relational connection, and creating practical pathways for participation in the Disciple-Maker Team Training (DMTT). The findings revealed that relational trust, intentional communication, and Spirit-led engagement …


The Black American Women, Mental Health, Self-Stigma, And The Church, Sylvia D. Dorsey Jun 2026

The Black American Women, Mental Health, Self-Stigma, And The Church, Sylvia D. Dorsey

Doctoral Dissertations and Projects

The purpose of this qualitative phenomenological study is to explore the lived experiences of Christian Black American women who underutilize mental health services due to a perceived notion of self-stigma of Christian Black American women seeking mental health services and how the church may play a role. A transformational theory guides this study. In a transformative framework the study focuses on looking at marginalized groups that have power differentials and are viewed as being less important in society and to understand their life experiences. Stigma and self-stigma are the dominating factors that contribute to the underutilization of mental health services …


Children With Cerebellar Malformations And Co-Occurring Autism: A Phenomenological Study Exploring Challenges Faced With The Dual Diagnosis Process, Service Acquisition, And Psychosocial Impacts, Ladeana W. Gambill Jun 2026

Children With Cerebellar Malformations And Co-Occurring Autism: A Phenomenological Study Exploring Challenges Faced With The Dual Diagnosis Process, Service Acquisition, And Psychosocial Impacts, Ladeana W. Gambill

Doctoral Dissertations and Projects

Parents of children who have been diagnosed with cerebellar malformations, such as Dandy-Walker Malformation, often face confusion and frustration as they are given uncertain prognoses about their child’s future. The uncertainty is further compounded when there are concerns for autism spectrum disorder (ASD), and testing is sought, with conflicting answers on whether their child has autism or not. Acquisition of autism-specialty services may be delayed if a diagnosis of autism is not received in a timely manner. The purpose of this interpretive phenomenological study was to understand the lived experiences and challenges faced by parents of children with cerebellar malformations …


Strengthening The Mind: Evaluating Emotional Intelligence As A Tool To Combat Anxiety In Youth Soccer, John P. Hill Jun 2026

Strengthening The Mind: Evaluating Emotional Intelligence As A Tool To Combat Anxiety In Youth Soccer, John P. Hill

Doctoral Dissertations and Projects

Competitive anxiety is a significant challenge for adolescent soccer players, contributing to psychological distress and early sport withdrawal, and approximately 70% of youth athletes quit organized sport by age 14. Emotional intelligence, the capacity to recognize, understand, and regulate emotions, represents a promising and trainable intervention target, yet few studies have examined structured EI programs with youth soccer populations using rigorous experimental designs that include a parallel control group. This quantitative intervention study examined the effect of an emotional intelligence intervention on competitive anxiety among youth soccer players, including whether individual emotional profiles and gender moderated outcomes.

A randomized controlled …


The Relationship Between Estimated Vo2max And Poor Mental Health: A Study Of Brfss Data, Angelina Somadina Oputa Jun 2026

The Relationship Between Estimated Vo2max And Poor Mental Health: A Study Of Brfss Data, Angelina Somadina Oputa

Doctoral Dissertations and Projects

Mental health conditions are one of the leading contributors to the global burden of disease. Despite advancements in mental health therapies and psychiatric medications, significant numbers of patients continue to struggle with mental illness. Despite these challenges, exercise can serve as a powerful tool to address mental health concerns. Current literature has referenced the value of physical fitness to support mental health, however there is limited large-scale research assessing the estimated maximal oxygen uptake (VO2Max) as a predictor of poor mental health days. In response, this quantitative secondary analysis was conducted to examine the relationship between estimated VO2Max and poor …


Technology Acceptance And Chatgpt Use In The Workplace, Niya Lewis Jun 2026

Technology Acceptance And Chatgpt Use In The Workplace, Niya Lewis

Doctoral Dissertations and Projects

Artificial intelligence is increasingly being integrated into organizations and workplaces increasing the need to better understand the influence this technology has on employees. Research investing psychological factors that influence employees' intended use and benefits of these technology tools will help to better understand strategies to support adaptation and effective use of these tools for employees. This quantitative correlational study examined the relationships among technology self-efficacy (TSE), perceived usefulness (PU), decision-making confidence (DMC), occupational self-efficacy (OSE), and technology acceptance (TA) of ChatGPT among working adults across various occupational sectors. Mediating and predictive mechanisms that influence workers objectives to engage with ChatGPT …


Bridging The Holler: A Case Study Of One Rural Appalachian Music Educator’S Engagement With Grants And Organizations, Kayla Renee Davis Jun 2026

Bridging The Holler: A Case Study Of One Rural Appalachian Music Educator’S Engagement With Grants And Organizations, Kayla Renee Davis

Doctoral Dissertations and Projects

This qualitative case study examines how partnerships with music organizations can support a rural music educator in a West Virginia county. The teacher’s needs were identified through an initial survey, interviews, and follow-up conversations, revealing four primary challenges: limited access to instruments and materials, barriers to recruitment and retention, isolation and constraints associated with itinerant teaching, and a need for culturally relevant curricular resources. Based on these findings, the researcher connected the teacher with organizations whose missions aligned with these areas: the West Virginia Music Educators Association for professional development and project grants; Be Part of the Music for recruitment …


The Impact Of Modern Police Equipment And Training On Reported Anxiety And Depression Of Police Officers, Matthew Roy Burford Jun 2026

The Impact Of Modern Police Equipment And Training On Reported Anxiety And Depression Of Police Officers, Matthew Roy Burford

Doctoral Dissertations and Projects

This quantitative study investigated the relationships among law enforcement officers’ access to modern equipment, their confidence in their training, and their reported levels of anxiety and depression. The study also tested whether confidence in training moderated the association between equipment and mental health outcomes. Mental health symptoms were measured using the Beck Depression Inventory (Beck et al., 1961) and the Beck Anxiety Inventory (Beck et al., 1988). Two researchers-developed instruments to assess officers’ perceived adequacy of their equipment and confidence in their training. Participants were recruited from law enforcement agencies across the Dallas–Fort Worth metroplex, and data were collected through …


Trading Podiums: Transitioning From Teaching Secondary Band To Teaching Secondary Orchestra In Eastern South Carolina, Troy M. Murray Jun 2026

Trading Podiums: Transitioning From Teaching Secondary Band To Teaching Secondary Orchestra In Eastern South Carolina, Troy M. Murray

Doctoral Dissertations and Projects

This qualitative, explanatory case study examined the musical attributes band teachers need to successfully teach string orchestra students in eastern South Carolina. This information is critical due to the high number of orchestra teachers who are non-string instrumentalists in that region of the state. Of the 28 orchestra teachers in South Carolina’s Region 5 orchestra division, 14 of the teachers performed primarily as wind or percussion instrumentalists. This study sought to understand the challenges teachers face when transitioning from teaching secondary band to secondary string orchestra in eastern South Carolina. Despite the parallels in music reading and repertoire selection between …


The Effect Of Structured Prebriefing On Pre-Simulation Anxiety In Baccalaureate Nursing Students Participating In High-Fidelity Simulation: A Quantitative Quasi-Experimental Nonequivalent Pretest-Posttest Control Group Study, Laura D. Wade Jun 2026

The Effect Of Structured Prebriefing On Pre-Simulation Anxiety In Baccalaureate Nursing Students Participating In High-Fidelity Simulation: A Quantitative Quasi-Experimental Nonequivalent Pretest-Posttest Control Group Study, Laura D. Wade

Doctoral Dissertations and Projects

The purpose of this quantitative quasi-experimental nonequivalent pretest-posttest control group study was to examine the effect of structured prebriefing on pre-simulation state anxiety among baccalaureate nursing students participating in high-fidelity simulation (HFS) at a private faith-based university in the South-Central United States (U.S.). Simulation is widely used in nursing education; however, nursing students frequently experience elevated anxiety prior to simulation that may negatively influence learning and performance. Despite recognition of prebriefing as best practice in simulation-based education, limited quantitative research has examined the effect of structured prebriefing on pre-simulation anxiety. A convenience sample of 73 baccalaureate nursing students enrolled in …


Morphodynamic Evolution Of Midnight Pass, West-Central Florida, Sydney C. Scott Jun 2026

Morphodynamic Evolution Of Midnight Pass, West-Central Florida, Sydney C. Scott

USF Tampa Graduate Theses and Dissertations

This study takes advantage of a rare opportunity provided by the reopening of Midnight Pass due to two consecutive hurricanes in 2024, to examine the morphologic evolution of a newly reopened inlet and subsequent beach-inlet interactions. Historical aerial photos since the 1940s were collected and analyzed to understand the last closure of Midnight Pass, and to gain knowledge on the future of the newly reopened inlet. Time-series topography and bathymetry survey of the beach-inlet system were conducted bimonthly to quarterly for the first year and a half after the reopening, with the goals of quantifying the morphologic changes and understanding …


Exploring Menstrual Cycle Experiences And Well-Being In Young Women With Type 1 Diabetes, Yolanda Rotzinger Ballesteros Jun 2026

Exploring Menstrual Cycle Experiences And Well-Being In Young Women With Type 1 Diabetes, Yolanda Rotzinger Ballesteros

USF Tampa Graduate Theses and Dissertations

Young women with type 1 diabetes (T1D) navigate complex physical, emotional, and social challenges, being at a higher risk for mental health concerns (e.g., depression), as well as physical (e.g., fatigue) and cognitive (e.g., focus) symptoms related to the management of their chronic health condition (Dantzer et al., 2003; Northam et al., 2005). About one-third of young women with T1D experience some form of menstrual dysfunction (Griffin et al., 1994; Schweiger et al., 2011), which is associated with lower quality of life across several domains, including the educational setting (Knox et al., 2015). Nevertheless, there is a gap in the …


Academic Library Staff And The Use Of Social Media: Survey Of Academic Library Staff At Pakpatan And Sahiwal City., Dr.Shahid Mehmood Dr., Muhammad Faisal Mr., Ahmad Nawaz Dr, Bakht Yar Zafar Mr., Whaid Buksh Mr. Jun 2026

Academic Library Staff And The Use Of Social Media: Survey Of Academic Library Staff At Pakpatan And Sahiwal City., Dr.Shahid Mehmood Dr., Muhammad Faisal Mr., Ahmad Nawaz Dr, Bakht Yar Zafar Mr., Whaid Buksh Mr.

Library Philosophy and Practice (e-journal)

The research libraries have benefited a lot with the aid of the social networking sites and this can hardly be overestimated. Due to the spread of the information technology in the university libraries, the user’s expectations, the type of services that the library can offer and the role of the library staff have all been changed. The research objective in general was to be familiar with the extent of familiarity and comfort of Pakpatan City library and Sahiwal City library staffs in Pakistan with the social media. The method of descriptive surveying was used to obtain these findings. The sample …


Computational Assessment Of A Lyophilized Native-Oxytocin Trehalose-Glass Formulation At Ph 4.5 For Thermostable Parenteral Use: Bayesian Shelf-Life Modeling From Published Degradation Kinetics With A Trehalose-Peptide Molecular-Dynamics Literature Synthesis, Chaiyapat Chuenglertsiri Jun 2026

Computational Assessment Of A Lyophilized Native-Oxytocin Trehalose-Glass Formulation At Ph 4.5 For Thermostable Parenteral Use: Bayesian Shelf-Life Modeling From Published Degradation Kinetics With A Trehalose-Peptide Molecular-Dynamics Literature Synthesis, Chaiyapat Chuenglertsiri

Defensive Publications Series

This in-silico feasibility analysis discloses, as defensive prior art (CC BY 4.0), a lyophilized formulation of native oxytocin in an amorphous trehalose dihydrate glass with D-mannitol crystalline bulking agent and a low-concentration sodium-acetate buffer fixing pH about 4.5 (the published maximum-stability pH), reconstituted on use for standard parenteral (IM/IV) administration to prevent postpartum haemorrhage. No wet-lab data are generated; all numbers are computational extrapolations from peer-reviewed parameters. Using the published Hawe et al. (2009) pH 4.5 Arrhenius kinetics (Ea = 116.3 kJ/mol) as a Bayesian prior, a PyMC posterior contrasts the aqueous product (retaining only about 25% intact oxytocin after …