Digital Commons Network^™

Cooling Conflict: Embedding Mediation Protocols In Data Center Land Sale Contracts, Allison Elias

Journal of Dispute Resolution

Imagine a two-thousand-acre plot of land in rural Louisiana being leveled to accommodate a 10 billion dollar data center. With the construction of this data center comes the destruction of a region inhabited by rich plant and animal life as well as 80,000 residents, a quarter of whom live below the poverty line. Alternatively, think of a $750 million data center being built next door to your home, causing sediment build-up in your water supply, water scarcity, light pollution, and destruction of neighboring forests. Unfortunately, one does not have to imagine these scenarios. Both stories come directly from recent news …

Reports Of Legal Writing’S Death Are Greatly Exaggerated: Why Generative Ai Will Not Kill The Craft, Jayne T. Woods

Journal of Dispute Resolution

In preparing for this essay, I typed the phrase “legal writing is” into Google to see how common searches finished the thought. The only completed thought to appear was “legal writing is hard.” Amen. Legal writing is an amalgamation of logical reasoning, cognitive psychology, classical rhetoric, legal terminology, legal citation, and proper grammar and style, all of which must result in a product accessible to readers of all education levels. When generative AI arrived, producing cogent, plausible legal prose in seconds, it led many to believe that writing, generally, and legal writing, specifically, had reached the end of days.

Justice After Atrocity: Lessons From Rwanda And Cambodia For Contemporary International Law And Conflict, Jennie Hubbard

Journal of Dispute Resolution

In the aftermath of mass atrocity, the question facing survivors and policymakers is not whether societies will rebuild but how rebuilding will address truth, justice, and memory. Modern transitional justice systems trace institutional and normative roots to the post—World War II order, most famously embodied by the Nuremberg Trials, which first established that individuals could be held accountable for crimes against humanity. Nuremberg did more than punish Nazi officials; it articulated a legal and moral principle that the international community could, and sometimes must, assert jurisdiction to address mass crimes when domestic systems fail. Despite that precedent, global reactions to …

Beyond City Limits: Access To Adr And Child Client-Directed Counsel In Missouri’S Rural Family Courts, Reghan Matlock

Journal of Dispute Resolution

Reba McEntire once sang, “Don’t trust your soul to no backwoods southern lawyer”—a warning that still echoes in today’s debates about rural justice and representation. The catchy murder ballad captures a story driven by dramatic family ties and a broken justice system. While the song exaggerates for effect, it taps into a realistic concern: an existing divide in access to justice between rural and urban communities. This divide impacts all areas of law, including family law—where concerns about confidentiality and privacy are heightened because small communities make it difficult to shield sensitive matters from public view. The divide is troubling, …

Reforming Mediation: The Hidden Inequities Shaped By Race, Gender, And Power, Victoria Seever

Journal of Dispute Resolution

Courts and policymakers often promote family dispute resolution as a faster, less adversarial alternative to traditional litigation. Yet for many women of color, the mediation table often replicates the same racial and gender power imbalances that the legal system claims to mitigate. Family Dispute Resolution (“FDR”) often fails women of color by reinforcing racialized and gendered power imbalances. Alternative dispute resolution (“ADR”), especially mediation, presents both an opportunity and a risk in divorce, custody, and intimate partner violence (“IPV”) cases. IPV cases become especially difficult with the various laws in different states that govern how mediation should be used and …

Mapping Dna Methylation Signatures To Identify Epigenetic Variation Across Subcortical Regions Of The Human Posttraumatic Stress Disorder Brain, Hongyu Li, Yujing Liu, Yiming Shi, Jiawei Wang, Tuan P Nguyen, Yuhan Xie, Wangjie Zheng, Youshu Cheng, Dianne A Cruz, Jennifer L Modliszewski, Rosemarie Terwilliger, Alexa-Nicole Sliby, José Jaime Martínez-Magaña, Janitza L Montalvo-Ortiz, John D Roache, Lynnette A Averill, Stacey Young-Mccaughan, Paulo R Shiroma, Bertrand R Huber, David A Lewis, Jill Glausier, Paul Holtzheimer, Matthew J Friedman, Jing Zhang, Alan L Peterson, Chadi G Abdallah, Amir Valizadeh, Xinyu Zhang, Ke Xu, John H Krystal, Ronald S Duman, Hongyu Zhao, David L Corcoran, Douglas E Williamson, Matthew J Girgenti

Staff and Researcher Publications

Background: Posttraumatic stress disorder (PTSD) is a mental disorder that may occur in the aftermath of severe psychological trauma. Epigenetic changes in the brain may play a critical role in understanding the neurobiology of PTSD by linking environmental traumatic stress exposure to lasting alterations in gene expression that shape neuronal function.

Methods: We examined 1,065,750 DNA methylation (DNAm) sites from 171 donors including neurotypical controls and PTSD and major depressive disorder (MDD) cases across 6 regions implicated in the fear circuitry of the brain. We performed RNA sequencing (RNA-seq) to examine changes in gene expression and linked these changes to …

The Geologic History Of The Chehalis Forearc Basin, Washington State, Usa, R. L. Moe, J. Bershaw, L. M. Staisch, A. R. Streig

Geology Faculty Publications and Presentations

The Chehalis basin is located between the Cascade arc and the Coast Range in southwest Washington State. It consists of sedimentary and volcanic rocks deposited throughout the Cenozoic and is underlain by the Siletzia terrane, a thick, large igneous province accreted in the Eocene. Here, we constrain evolution of the Chehalis basin depocenter using isochore maps derived from isostatic gravity anomalies, borehole data, and stratigraphy for several time periods: the Eocene (47.6–36.8 Ma), the Oligocene (36.8–20 Ma), and the Neogene (20–0 Ma). Our results suggest that local subsidence is driven by deformation on faults that bound and intersect the basin. …

Statistical Evaluation Of A New Orleans Historic Rainfall Dataset (1840–1893), Arielle C. Filostrat

LSU Master's Theses

This study evaluates the climatic credibility of a newly identified historical rainfall dataset for New Orleans, Louisiana, spanning 1840–1893. The New Orleans Historical Dataset (NOHD) is compared to a modern observational record from the Audubon rain gauge (1893–2024) to determine whether nineteenth-century rainfall observations are consistent with known precipitation behavior in the region. Establishing the reliability of early records is critical for extending climatological baselines and improving understanding of long-term rainfall variability.

Historical rainfall observations were first evaluated through archival review using the New Orleans Medical and Surgical Journal and other nineteenth-century meteorological records to verify notable rainfall events. Daily …

A Call To Investigate The Association Between Histoplasmosis And Fatigue, Christian Hendrix, Julio Zuniga-Moya, Andrej Spec, Patrick Mazi

2020-Current year OA Pubs

Historically, infections are subjectively associated with fatigue, a common yet poorly delineated syndrome. The impact on patient quality of life is the ultimate justification to evaluate fatigue in patients with infections. While fungal infections are subjectively associated with fatigue, there are minimal quantifiable fungal research outcomes that evaluate histoplasmosis and fatigue.

The Unexpected Role Of Conditionality In Shaping Relational Values: Insights From An Incentive-Based Conservation Program In Bolivia, Brooke Mcwherter, Will Munger, Zhao Ma, Claudia Radel, Laura Zanotti, Jonathan Bauchet, Ricardo Godoy

Department of Agricultural Economics Faculty Publications

As global change accelerates, Payments for Ecosystem Services (PES) programs have become increasingly important tools for addressing the interconnected challenges of land degradation, biodiversity loss, water scarcity, and climate change. PES programs provide incentives to individuals or communities, conditional on people adopting sustainable natural resource management practices to support or increase ecosystem service provisioning. Although conditionality is considered a “PES-defining feature,” little is known about how conditionality is perceived by community members and how such perceptions influence their participation in and experience with PES programs. To address this gap, we conducted an extensive qualitative study of Watershared, an incentive-based conservation …

Amplifying Change For Adolescent Girls In West And Central Africa Through Economic Empowerment, Mame Soukeye Mbaye, Sarah Engebretsen, Maty Dia, Karen Austrian

Adolescents and Young People

The Girls’ Futures in Focus: Evidence from West and Central Africa series examines the challenges facing adolescent girls in the region and highlights evidence-informed approaches to improving their lives. This brief summarizes the evidence on adolescent girls’ economic empowerment—income, livelihoods, savings, financial inclusion, agency, transition to work, or all of the above—in West and Central Africa, drawing in particular on evidence from the GIRL Center’s priority countries. The brief points to what shifts adolescent girls’ economic trajectories in the region, especially in fragile and low-resource settings.

Understanding The Lubrication Mechanisms Of Environmentally Compatible Protic Ionic Liquids, Davis Kipkania Kiboi

Theses

The development of environmentally sustainable lubricants is increasingly important as industries seek to reduce friction, wear, energy losses, and environmental impact. Choline amino acid protic ionic liquids (PILs) have emerged as promising candidates due to their bio-based constituents, tunable molecular structures, and favorable lubrication properties. However, the influence of amino acid structure on their lubrication mechanisms and tribological performance remains poorly understood. This dissertation investigates the physicochemical properties, tribological behavior, and tribofilm formation mechanisms of choline amino acid PILs to establish structure–property–performance relationships for sustainable lubricant design. Ten choline amino acid PILs containing glycine, alanine, lysine, leucine, isoleucine, aspartic acid, …

The Impact Of Alexithymia On Body Image: The Mediating Role Of Rumination Among Students At Sultan Qaboos University, Fatima Alrahbi, Mai Helmy, Amal Alhadabi

Journal of Educational and Psychological Studies

The study aimed to examine the mediating role of rumination in the relationship between the dimensions of alexithymia and body image among first-year students at Sultan Qaboos University in the Sultanate of Oman. The descriptive method was employed, and the sample consisted of 310 male and female first-year students at Sultan Qaboos University, who were selected using a convenience sampling method. The study instruments included three scales: the Body Image Scale, the Toronto Alexithymia Scale, and the Rumination Scale. The results indicated the presence of statistically significant direct effects of the dimensions of alexithymia on rumination. The findings showed that …

Mindfulness And Its Relationship To Cognitive Flexibility Among University Students, Nafez Ahmad Abed Bukaiei, Adnan Mahmoud Hassan Odeh

Journal of Educational and Psychological Studies

This study aims to examine the relation between mindfulness and cognitive flexibility among university students. It also aimed to identify the level of mindfulness and the level of cognitive flexibility based the variables of gender, grade point average, and school year level. To achieve the aims of this study, the descriptive correlational approach was adopted through the use of the mindfulness scale of Bear & Others (2006) which was translated into Arabic by Al-Buhairi et al. (2014) and the cognitive flexibility scale of Dennis & Vander Wal (2010) which was translated by the researchers. The sample group consisted of 185 …

Caregiver Health Literacy Is Associated With Pediatric Burn Recovery Outcomes, Ananya Sampathkumar, Anna Sabukurian, Erin M. Morris, Alyssa M. Griffith, Nicholas A. Long, Alexa Cumming, Macie Boden, Christina G. Morris, Lauren K. Mayon, Thian H. Nguyen, Allison L. Speer, Natalie A. Drucker

Summer Research Program Abstracts

No abstract provided.

Sex Differences In Surveillance Outcomes Of Thoracic Aortic Disease: Insights From The “Watchful Waiting” Study, Trang H. Do, Brian Shukwit, Minjae Lee, Siddharth K. Prakash

Summer Research Program Abstracts

No abstract provided.

An Integrated Cardiometabolic Genetic Testing Program In A Predominantly Hispanic Population Within A Community Setting, Bo Yuan, Layla A Abushamat, Stacey Pereira, Surya Narayan Mulukutla, Grace E Tietz, Eric Venner, Sara E Kalla, Breanna Lee, Donna Muzny, Ginger Metcalf, Mullai Murugan, Sarah H Elsea, Senkottuvelan Kadirvel, Lele Li, Joshi Stephen, Shengfeng Xu, Victoria Yi, Monica Sulit, Christie L Kovar, Kimberly Walker, Marie-Claude Gingras, Jianhong Hu, Fei Yan, Taeko Gerber, Viktoriya Korchina, C Michael Fordis, Ruchi Gaba, Mahesh Changlani, Herschl Silberman, Hadley Stevens Smith, Christine M Eng, Jennifer E Posey, Clarisa Medina, Lisa R Treviño, Christie M Ballantyne, Richard A Gibbs, Ashok Balasubramanyam

Center for Medical Ethics and Health Policy Staff Publications

Purpose: This study aimed to apply cardiometabolic genetic testing in a community setting with a predominantly Hispanic population and assess feasibility and perspectives toward genetic testing.

Methods: A genome-sequencing-based genetic panel for cardiometabolic disorders (177 genes related to monogenic conditions, 2 LPA risk alleles, 2 pharmacogenomic loci, and ancestry-adjusted polygenic risk scores for type 2 diabetes and coronary artery disease) was deployed in community cardiology and endocrinology clinics in South Texas. A survey on perceptions toward genetic testing was administered after return of results.

Results: Testing was completed for 776 patients (18-92 years old, 92% Hispanic). 26 patients (3.4%) were …

Patient Perspectives On Psychiatric Polygenic Risk Scores In Reproductive Decision-Making And Polygenic Embryo Screening., Lauren A Ginn, Amanda R Merner, Page M Trotter, Kaitlynn P Craig, Abigail C Martinez, Ana Lucía Battaglino, Dorit Barlevy, Daphne M Ayton, Takahiro Soda, Eric A Storch, Gabriel Lázaro-Muñoz, Stacey Pereira

Center for Medical Ethics and Health Policy Staff Publications

Polygenic risk scores (PRS) estimate individuals' genetic risk for developing multifactorial conditions. Recent genome-wide association studies have enabled development of psychiatric PRS, which hold potential to streamline diagnosis and treatment of psychiatric conditions. As individuals with mental illness often identify concern about passing on psychiatric conditions as a key factor in family planning, some may also seek to use psychiatric PRS in reproductive decisions like childbearing or embryo selection for in vitro fertilization. Despite calls for increased regulation, there remains no clinical consensus on the utility of psychiatric PRS in reproductive contexts. Therefore, we conducted semi-structured interviews of adults with …

Making Ai Interesting And Safe For K-6 Students, Anshi Moreno Jimenez, Fred Klein, Mason Dong, Kunal Jain, Jasmine Gu, Yuanheng Mao

Paul English Applied Artificial Intelligence (AI) Institute Publications

This group project explores strategies for making artificial intelligence engaging, educational, and safe for K-6 students. The project addresses concerns associated with irresponsible AI use, including risks to children, unnecessary use of natural resources and computing power, and the development of unproductive AI habits. It presents classroom activities designed to help young students understand AI as a technology rather than simply a toy. One activity uses AI-generated images to encourage creativity, clear communication, critical analysis, collaboration, and reflection on the computational costs and limitations of generative AI. A second activity, “AI Detective,” teaches students to critically evaluate AI-generated responses for …

July 2026, Swosu Rural Health Center

RURAL ROCKS

Rural Health Center

As we prepare to kick off our first semester in the new Jerry & Margaret Hodge College of Pharmacy and Rural Health Center, there is a lot to be excited about! It has been incredible to watch this vision become a reality, and we can't wait to welcome students, faculty, healthcare partners, and community members into a space designed to strengthen rural healthcare across western Oklahoma. The opportunities for collaboration, education, and innovation are endless, and we are especially looking forward to creating more hands-on learning experiences for our students while continuing to build strong partnerships that …

Cytokine-Based Strategies To Improve Prognostic Enrichment Of Pediatric Ards, E Scott Halstead, Todd M Umstead, Zissis C Chroneos, Cainan Riccio-Baum, S Rameeza Allie, Daniel J Mckeone, Debbie Spear, Ryan A Nofziger, Ronald C Sanders, Danielle Ahn, Jasmine C Dowell, Asdis F Wagner, Neal J Thomas, Prithvi Sendi, W Joshua Frazier, Courtney M Rowan, Parag N Jain, Dalia A Bashir, Stuart H Friess, Brian M Varisco, Jocelyn Grunwell, Aline B Maddux, Stephen T Famularo, Nadir Yehya

Faculty, Staff and Students Publications

Background: Hyper-inflammation is common to multiple critical care syndromes, including acute respiratory distress syndrome (ARDS) and sepsis, and is associated with worse outcomes. A signature of hyper-inflammatory ARDS has been described in adults using IL-6, TNFR1, and bicarbonate, and has prognostic utility. We investigated the application of this traditional parsimonious signature to pediatric ARDS patients and tested whether we could improve prognostic enrichment using other cytokines.

Methods: We leveraged a prospective multicenter cohort study of 500 children with ARDS (Linking Endotypes and Outcomes in Pediatric Acute Respiratory Distress Syndrome [LEOPARDS]; NCT04113434) study. Plasma samples were obtained within 24 h …

Reclassifying Pediatric Nafld Using The Steatotic Liver Disease Framework: A Multicenter Retrospective Study From The Nash Crn, Tin Bo Nicholas Lam, Katherine P Yates, Sheila L Noon, Kimberly P Newton, Mark H Fishbein, Jean P Molleston, Stavra A Xanthakos, Ajay K Jain, Miriam B Vos, Niviann M Blondet, Krupa R Mysore, Cynthia A Behling, Laura A Wilson, Jeffrey B Schwimmer

Faculty, Staff and Students Publications

Background and aims: The terminology for hepatic steatosis and NAFLD was revised under the umbrella of steatotic liver disease, with metabolic dysfunction-associated steatotic liver disease (MASLD) as the primary subtype. MASLD is defined by hepatic steatosis plus at least 1 cardiometabolic risk factor. A new category, Met-ALD, describes MASLD with alcohol consumption below the defined thresholds for alcohol-associated liver disease (ALD). While adult studies have demonstrated strong concordance between NAFLD and MASLD, the applicability of this framework in children remains unclear.

Approach and results: We assessed children clinically diagnosed with NAFLD and enrolled in the NASH CRN who had available …

Quality Domains In Home-Based Pediatric Hospice And Palliative Care: Adolescent And Young Adult Perspectives, Daniel H Grossoehme, Claire A Crawford, Jhansi Chandra Ellakula, Toluwalase Ajayi, Justin N Baker, Sarah Friebert, Lisa Humphrey, Jillann Jarrell, Rachel Thienprayoon, Pamela S Hinds

Faculty, Staff and Students Publications

Background: Current United States palliative care practice guidelines are intended to cover care across all age groups. Previous research with pediatric providers and caregivers concluded that pediatric hospice and palliative care have unique attributes. Not known is how adolescent hospice and palliative care patients understand quality palliative care. The purpose of this study was to characterize and define quality of care domains as described by adolescent and young adult patients receiving home-based hospice and palliative care.

Methods: Semi-structured interviews with 10-26 year-olds who received home-based hospice and/or palliative care visits in the prior three years at six diverse sites in …

Longitudinal And Cross-Sectional Evidence That Daily Resting And Activity Energy Expenditures Are Independent In Humans, Andrew K Yegian, Elizabeth Pachus, Leanne M Redman, Steven B Heymsfield, K Falkenhain, Alexandra R Harris, Shaji K Chacko, William W Wong, Daniel E Lieberman

Faculty, Staff and Students Publications

Total energy expenditure (TEE) is commonly modelled as the sum of resting energy expenditure (REE), activity energy expenditure (AEE), and diet-induced thermogenesis (DIT). This additive model has recently been challenged by the constrained energy balance model, which proposes that reductions in mass-adjusted REE compensate to some extent for increases in AEE, rendering mass-adjusted TEE effectively invariant. We tested these competing models using two complementary approaches. First, we conducted a short-term longitudinal, repeated-measures experiment in 12 adults who completed 10-day periods of high and low physical activity separated by a washout period. TEE was measured with doubly labelled water, AEE with …

Human Exposure To Spirochete-Infected Ornithodoros Turicata In A Residential Setting In The Austin, Texas Metropolitan Area, Serhii Filatov, Bonny Mayes, Sarah M Gunter, Alexander R Kneubehl, Job E Lopez

Faculty, Staff and Students Publications

A central Texas resident found an engorged Ornithodoros turicata tick attached to their ankle while at home. The tick tested positive for Borrelia turicatae, an agent for soft tick-borne relapsing fever. Three weeks earlier, the patient started experiencing febrile episodes, rash, and nausea, yet the etiological agent went undiagnosed.

Na-Gst-1 Adsorbed On Alhydrogel Co-Administered With Different Toll-Like Receptor Agonists In Hookworm-Naive Adults Using A Controlled Human Infection Model In The Usa: A Phase 2, Double-Blind, Randomised Controlled Trial, Caroline K Dirosato, Elissa M Malkin, Sean M Lee, Guacyara Erwin, Lara Hoeweler, Larissa Scholte, Maria Elena Bottazzi, David I Pritchard, Peter J Hotez, Jeffrey M Bethony, David J Diemert

Faculty, Staff and Students Publications

Background: Necator americanus glutathione S-transferase-1 (Na-GST-1) performs a crucial enzymatic step in hookworm blood feeding and is a leading target for vaccine development. Phase 1 trials in Brazil, Gabon, and the USA of recombinant Na-GST-1 adsorbed on Alhydrogel (Na-GST-1/Al), co-administered with or without AP 10-701 (Toll-like receptor [TLR] 4 agonist) or CpG 10104 (TLR9 agonist), showed the vaccine was well tolerated, safe, and immunogenic. A controlled human hookworm infection (CHHI) model was previously developed to evaluate the effect of candidate hookworm vaccines on infection. We aimed to assess the effect of vaccination with three different Na-GST-1 vaccine formulations on subsequent …

Comprehensive Assessment Of Direct And Passive Smoking Across The Pancreatitis Spectrum, Samuel Han, Dhiraj Yadav, Jun Xu, Melena D Bellin, William E Fisher, Evan L Fogel, Chris Forsmark, Phil A Hart, Liang Li, Stephen J Pandol, Walter G Park, Guru Trikudanathan, Stephen K Van Den Eeden, Santhi Swaroop Vege, Darwin L Conwell, Christie Y Jeon, Consortium For The Study Of Chronic Pancreatitis, Diabetes, And Pancreatic Cancer (Cpdpc)

Faculty, Staff and Students Publications

Objectives: Smoking is a key risk factor for pancreatitis, contributing to pathogenesis and disease progression. Data regarding second-hand smoking, or passive smoking (PS) exposure, are lacking. We therefore aimed to assess the impact of PS exposure across the pancreatitis spectrum.

Methods: We analyzed baseline data from the PROCEED study, a multicenter study in the United States including patients with acute (AP), recurrent acute (RAP), and chronic (CP) pancreatitis. Participants detailed their individual smoking history and PS exposure, which was compared between AP, RAP, and CP subgroups. Participant factors and clinical characteristics were compared by level of individual and PS exposure. …

Incidence And Outcomes Of Treatment-Associated Hepatotoxicity During Pediatric Acute Lymphoblastic Leukemia Induction Therapy: A Reducing Ethnic Disparities In Acute Leukemia (Redial) Consortium Report, Ashley N Chavana, Emily J Mason, John P Woodhouse, Olga A Taylor, Monica M Gramatges, Joanna S Yi, Sandi Pruitt, M Brooke Bernhardt, Kathleen Ludwig, Laura Klesse, Kenneth Heym, Timothy Griffin, Marley Roberts, Rodrigo Erana, Juan Carlos Bernini, Hong Zhu, Philip J Lupo, Karen R Rabin, Michael E Scheurer, Steven D Mittelman, Van Huynh, Etan Orgel, Austin L Brown

Faculty, Staff and Students Publications

No abstract provided.

Mechanisms Coordinating Exit From The Stem Cell State In Mammals, Emily J Park, Florencia Levin-Ferreyra, Bruno Di Stefano

Faculty, Staff and Students Publications

Differentiation requires coordinated exit from the stem cell state, during which gene regulatory networks sustaining self-renewal are dismantled, while lineage-specific programs are activated. This transition is governed by chromatin modifications, transcriptional networks, RNA processing, translational control, and metabolic rewiring that must operate with temporal precision. Despite significant progress in identifying individual regulatory components, understanding how these layers integrate to orchestrate irreversible cell fate commitment remains a fundamental challenge. This review examines common and unique regulatory principles governing stem cell exit, from totipotency during early embryogenesis to tissue-specific stem cell differentiation in adults. We synthesize recent findings on regulatory mechanisms across …

Nuclear-Specific Reductive Carboxylation Of Alpha-Ketoglutarate Fuels Histone Acetylation To Induce Chromatin Accessibility And Gene Activation, Abhisha Sawant Dessai, Nadya A Elhalawany, Tao Dai, Justine J Jacobi, Christian Prechtl, Alphonse N Dimeck, Sierra R Morton, Mark D Long, Prashant K Singh, Nagireddy Putluri, Mariana Lopes, Song Liu, Dominic J Smiraglia, Katerina V Gurova, Peder J Lund, Leah A Gates, Sung Yun Jung, Subhamoy Dasgupta

Faculty, Staff and Students Publications

Mitochondria remain at the core of cell metabolism, whereas the nucleus integrates cellular and environmental signals to activate genes. However, the mechanisms that directly link cellular metabolism to gene regulation are not well understood. Here we show, a metabolic pathway in the nucleus controls acetylation of histones by nuclear localization of mitochondrial enzymes aconitase (ACO2) and isocitrate dehydrogenase (IDH2). Metabolic tracing studies show that IDH2 and ACO2 catalyze reductive carboxylation of α-ketoglutarate to rapidly synthesize citrate to increase nuclear acetyl-CoA pool. Genetic and proteomic analyses reveal nuclear IDH2 and ACO2 form a complex with KAT2A/GCN5 for acetylation of histones to …