Digital Commons Network^™

Long-Term Techno-Economic Analysis Considering System Strength And Reliability Shortfalls Of Electric Vehicle-To-Grid-Systems Installations Integrated With Renewable Energy Generators Using Hybrid Gru-Classical Optimization Method, Md Ohirul Qays, Iftekhar Ahmad, Daryoush Habibi, Paul Moses

Research outputs 2022 to 2026

Higher penetration of Electric Vehicle-to-Grid charging stations (EV2GCSs) in power grids integrated with renewable energy generators (REGs) result in system-instabilities raising the risk of blackout issues. Although techno-economic feasibility of EV2GCSs has been identified within the literature addressing power outage and financial concerns as a contemporary solution, no long-term techno-economic analysis has been investigated considering system strength and reliability shortfalls before the EV2GCSs installation. Therefore, this research aims to evaluate the long-term (2025–2045) techno-economic analysis of EV2GCSs into REGs-integrated grid systems by accounting for system strength and reliability factors. A novel optimization framework is developed, combining Gated Recurrent Units (GRU) …

Photo-Thermal Conversion Properties Of Mxene/Metal-Organic-Frameworks-Based Nanofluids For Solar Energy Harvesting, Seyedeh Zahra Haeri, Ali Dashan, Samira Sadeghi, Mitral Golgoli, Mehdi Khiadani, Bahram Ramezanzadeh, Masoumeh Zargar

Research outputs 2022 to 2026

This study focuses on enhancing solar energy capture efficiency by introducing innovative hybrid nanofluids for use in solar thermal collectors, whose performance largely depends on the absorption properties of the working fluid. The newly developed hybrid nanofluids, MXene/NH2-UiO66 (Zr) (noted as MX/UO66) and MXene/MIL-88B (Fe) (noted as MX/ML88), were synthesized using an in-situ solvothermal method, combining annealed Ti3C2Tx MXenes with water-stable metal–organic frameworks (MOFs). These nanofluids achieved high efficiency at low concentrations, providing both economic and performance benefits. Comprehensive testing compared the photothermal properties of these hybrids with single-component UO66 and ML88 nanofluids. The MX structures significantly expanded the absorption …

Performance Comparison Of Flat Sheet And Hollow Fibre Air Gap Membrane Distillation: A Mathematical And Simulation Modelling Approach, Hamed Kariman, Hussein A. Mohammed, Masoumeh Zargar, Mehdi Khiadani

Research outputs 2022 to 2026

Membrane Distillation (MD) systems could address current challenges related to global water demand. Among MD systems, Air Gap Membrane Distillation (AGMD) systems play crucial roles in addressing this challenge. AGMD systems can be categorized into two main structural groups: flat sheet and hollow fibre forms. It is important to study, analyse, model and compare these two systems under the same operational conditions. In this study, a detailed mathematical model of flat sheet and hollow fibre AGMD modules under the same conditions (i.e., membrane type, membrane area, porosity, and pore radius of membrane) has been introduced. The simulation of system performance …

Navigating The Complexities Of End-Stage Kidney Disease (Eskd) From Risk Factors To Outcome: Insights From The Uk Biobank Cohort, Debasish Kar, Richard Byng, Aziz Sheikh, Mintu Nath, Bedowra Zabeen, Shubharthi Kar, Shakila Banu, Habibur Rahman, Navid Khan, Durjoy Acharjee, Shafiqul Islam, Victoria Allgar, Jose Ordonez-Mena, Aya El-Wazir, Soon Song, Ashish Verma, Umesh Kadam, Simon De Lusignan

Peninsula Medical School

BACKGROUND: The global prevalence of end-stage kidney disease (ESKD) is increasing despite optimal management of traditional risk factors such as hyperglycaemia, hypertension, and dyslipidaemia. This study examines the influence of cardiorenal risk factors, socioeconomic status, and ethnic and cardiovascular comorbidities on ESKD outcomes in the general population.

METHODS: This cross-sectional study analysed data from 502,408 UK Biobank study participants recruited between 2006 and 2010. Multivariable logistic regression models were fitted to assess risk factors for ESKD, with results presented as adjusted odds ratio (aOR) and 95% confidence intervals (95% CI).

RESULTS: A total of 1191 (0.2%) of the study participants …

“We're Not One-Box Issue People”: Intersectional Perspectives On Lgbtq+ Mental Health In Schools: A Uk Qualitative Study With Students, Staff And Training Providers, Charlotte Woodhead, Amy Morgan, Ibrahim Sabra, Sara Sabra, Lukasz Konieczka, Gemma Knowles, Emily Cunningham, Juliet Dryud, Liberty Elliott, Lauren Ige, Angela Mascolo, E. Singh, Katharine Rimes

School of Psychology

Abstract There is limited intersectionality-informed, contextually diverse qualitative research on school experiences of LGBTQ+ students and links to mental health. Focusing on racialized, ethnic minority and religious/faith groups, this coproduced UK study examines how: 1) sexual and/or gender diverse students with intersecting minoritized identities experience school; 2) school environments could better support their mental health; and 3) what shapes school inclusion initiatives. In-depth interviews and focus groups were conducted with 22 staff members, 32 students (13–19 years), and nine LGBTQ+ school inclusion training providers. The sample was diverse across gender and sexual identity, race/ethnicity, religion and context. Data were analysed …

University Administrators’ Perceptions On Social Inequalities And Retention Of First-Year African American Students At Historically Black Colleges And Universities (Hbcus), Toni V. Smith

Electronic Theses and Dissertations

Low retention rates of African American students in U.S. higher education institutions remain an issue, with researchers exploring possible contributing factors, including social inequalities. This qualitative descriptive study explored the perspectives of administrators from Historically Black Colleges and Universities (HBCUs) on the unique barriers African American students face in the HBCU context, including financial hardship, academic unpreparedness, and limited opportunities for social integration. Data were collected through detailed, voice-recorded, semistructured interviews conducted via Zoom with administrators, including provosts, presidents, and directors from 12 current and former HBCUs, to explore how policies initially perceived as unfavorable could positively impact institutional leadership …

The Influence Of Leadership Behaviors On School-Based Speech-Language Pathologists' Perception Of Burnout, Emily A. Lambert

Electronic Theses and Dissertations

Current research on burnout and attrition of school-based speech-language pathologists (SLPs) focused on the reason for attrition, which has remained relatively consistent across time. Despite identifying the factors contributing to attrition, minimal research has focused on how SLPs can prevent burnout or how to improve SLP retention rates in schools. Self-determination theory, fulfillment of competence, autonomy, and relatedness increase intrinsic motivation. The purpose of this phenomenological study was to identify how SLPs employed in Texas school districts described the factors contributing to their resilience in remaining employed in the schools. Fifteen SLPs participated in semistructured interviews about their perception of …

Improving Timely Administration Of Venous Thromboembolism Prophylaxis Within A Medical Surgical Unit, Valerie Escamilla

Electronic Theses and Dissertations

Hospital-acquired venous thromboembolisms are a highly preventable condition. Despite the availability of multiple evidence-based guidelines, there continues to be suboptimal use of timely venous thromboembolism prophylaxis. The purpose of this doctoral nursing quality improvement project was to determine if the implementation of an Agency for Healthcare Research and Quality Hospital-Associated Venous Thromboembolism Prevention Guideline would impact the rate of timely administration of venous thromboembolism prophylaxis as compared to current practice in hospitalized adult patients admitted to a medical-surgical unit over 4 weeks. The organization measures the rate of timely administration of prophylaxis by monitoring the VTE-1 metric. All medical-surgical units …

Women Overcoming Barriers In Stem: How Mentors, Allies, And Sponsors Assist Career Trajectories In Higher Education, Leila Marie Romeo

Electronic Theses and Dissertations

This study focused on the personal narratives of women in STEM in both public and private higher education institutions within various roles. Specifically, the researcher aimed to determine the following: (a) if mentors/allies influence the career trajectories of women in STEM in higher education institutions and (b) if mentors/allies aid in the support of women in STEM in higher education institutions. The researcher used semistructured interviews with a narrative analysis to determine areas of struggle for the sample within their careers and how mentors, allies, and sponsors were present throughout their careers to help the women overcome these challenges. Data …

Impact Of A Transplant Nurse Navigator In The Dialysis Setting, Judith D. Pozzerle

Electronic Theses and Dissertations

Patients with kidney disease have better patient outcomes and quality of life with a kidney transplant. However, the transplant process is complicated with inherent inequalities and biases and patients frequently fail to initiate a referral for transplant evaluation. The Centers for Medicare and Medicaid have now placed financial incentives to improve the number of patients transplanted. The only way to increase the number of patients transplanted is to start with a referral for evaluation. Studies have been done highlighting the barriers, but there is a lack of studies implementing strategies to improve these numbers. Utilizing Kotter’s change theory and describing …

Staff Education To Improve Medication Nonadherence In Behavioral Clinic, Evette Amundam Akam

Walden Dissertations and Doctoral Studies

The project is a staff education initiative to address medication nonadherence in a behavioral health outpatient clinic. The practice-focused question underpinning this project was, Will a staff education program with essential components improve staff knowledge, skill, and attitudes, ultimately improving medication adherence among behavioral health patients in outpatient clinics? I sought to design, implement, and evaluate an evidence-based educational program that equips healthcare providers with the knowledge and skills to identify, address, and overcome barriers to medication adherence. I used both quantitative and qualitative analytical methods. The results demonstrate improvements, with the average knowledge score increasing from 62.75% to 96% …

Arab Americans’ Views Of Arab Lobbying Efforts Related To The Palestinian-Israeli Conflict, Samar Farha

Walden Dissertations and Doctoral Studies

Research on ethnic lobbying has largely neglected the perspectives of Arab Americans, creating a disconnect between this community and their lobbying efforts. This gap is crucial because it threatens to widen the disconnect between Arab Americans and their lobbying groups, where effective lobbying depends on a unified message. Existing studies highlight this gap, pointing out the lack of unified organization and ongoing resource constraints that limit the influence of Arab American lobbyists on U.S. foreign policy. The purpose of this generic qualitative was to explore Arab Americans’ perceptions of their lobbying efforts and the factors shaping these perceptions based on …

Reserve Officer Training Corps Officers’ Perspectives On Diversity, Equity, And Inclusionary Practices In Commissioning Minority Officers In The U.S. Military, Christopher Tompkins

Walden Dissertations and Doctoral Studies

The problem addressed in this study was the lack of research on Reserve Officer Training Corps (ROTC) officers’ practices using diversity, equity, and inclusionary (DEI) in commissioning minority officers in the U.S. military. This deficiency of literature and research illustrates the necessity to explore ROTC officers' perspectives of practices in this context. The purpose of this qualitative study was to explore ROTC officers’ perspectives on DEI practices related to commissioning minority officers in the U.S. military. The conceptual framework was grounded in critical race theory and aversive racism theory. The research question was focused on ROTC officers' perspectives on DEI …

Kindergarten Through Sixth Grade Teachers’ Experiences Of Conflict Resolution Instruction In Social And Emotional Learning Curricula, Bethany Kristen Danjuma

Walden Dissertations and Doctoral Studies

Educators have agreed that an education should include the development of social-emotional competencies and conflict resolution (CR) skills. However, only some social-emotional learning (SEL) programs are designed to promote mastery of CR skills. The problem this study addressed was the increase in behavioral incidents in public Colorado elementary schools despite incorporation by kindergarten to sixth (K–6) grade teachers of SEL instruction to prevent student conflict. The purpose of this study was to explore Grade K–6 teachers' successes, challenges, and suggestions for improvements to incorporate CR instruction into SEL curricula at public Colorado elementary schools. Bandura's social learning theory and the …

Forging Sustainable Retention Strategies For Medical-Surgical Registered Nurses In Rural Texas Hospitals, Yvette Eartha Stephenson

Walden Dissertations and Doctoral Studies

Background: Health care delivery in rural medical-surgical units is significantly hindered by nurse shortages, particularly in underserved areas. While various approaches to retention have been studied, there remains a lack of focus on sustainable strategies explicitly tailored for rural settings. Purpose: In this integrative review, guided by the situational leadership theory (SLT) framework, sustainable nurse retention strategies for rural medical-surgical units were investigated. The SLT emphasizes four leadership components, supporting, delegating, directing, and coaching, which were the foundation for categorizing themes and subthemes in this analysis. Method: A review of peer-reviewed literature published between 2019 and 2024 was conducted while …

Suppression Of Hypothalamic Oestrogenic Signal Sustains Hyperprolactinemia And Metabolic Adaptation In Lactating Mice, Meng Yu, Bing Feng, Jonathan C Bean, Qianru Zhao, Yongjie Yang, Hailan Liu, Yongxiang Li, Benjamin P Eappen, Hesong Liu, Longlong Tu, Kristine M Conde, Mengjie Wang, Xi Chen, Na Yin, Darah Ave Threat, Nathan Xu, Junying Han, Peiyu Gao, Yi Zhu, Darryl L Hadsell, Yang He, Pingwen Xu, Yanlin He, Chunmei Wang

Faculty, Staff and Students Publications

17β-oestradiol (E2) inhibits overeating and promotes brown adipose tissue (BAT) thermogenesis, whereas prolactin (PRL) does the opposite. During lactation, the simultaneous decline in E2 and surge in PRL contribute to maternal metabolic adaptations, including hyperphagia and suppressed BAT thermogenesis. However, the underlying neuroendocrine mechanisms remain unclear. Here, we find that oestrogen receptor alpha (ERα)-expressing neurons in the medial basal hypothalamus (MBH), specifically the arcuate nucleus of the hypothalamus and the ventrolateral subdivision of the ventromedial hypothalamus (vlVMH), are suppressed during lactation. Deletion of ERα from MBH neurons in virgin female mice induces metabolic phenotypes characteristic of lactation, including hyperprolactinemia, hyperphagia …

Words Of Advice: How To Write The Story Of A Patient For A Problem-Based Learning Session In A Healthcare Education Program, Andrew D Bergemann, Matthew Mcmillin, Miriah C Gillispie-Taylor, Gareth Gingell, R Taylor Surles, Rachel Wallace

Faculty and Staff Publications

Medical education is in the process of a pedagogical revolution. Traditional lectures are playing a progressively smaller role, with more of the content being delivered through student-centered small-group sessions. Problem-based learning (PBL) has become a centerpiece of education for many medical schools, in large part because of its focus on the learners identifying their own knowledge gaps. As junior scientists seek faculty appointments in institutions focused on healthcare education, they will find that skills in PBL are valued by the academic community. Among the necessary skills is the capability to lead efforts in PBL case writing. The cases, each of …

Revisions To The Safety Assurance Factors For Electronic Health Record Resilience (Safer) Guides To Update National Recommendations For Safe Use Of Electronic Health Records, Dean F Sittig, Trisha Flanagan, Patricia Sengstack, Rosann T Cholankeril, Sara Ehsan, Amanda Heidemann, Daniel R Murphy, Hojjat Salmasian, Jason S Adelman, Hardeep Singh

Faculty, Staff and Student Publications

The Safety Assurance Factors for Electronic Health Record (EHR) Resilience (SAFER) Guides provide recommendations to healthcare organizations for conducting proactive self-assessments of the safety and effectiveness of their EHR implementation and use. Originally released in 2014, they were last updated in 2016. In 2022, the Centers for Medicare and Medicaid Services required their annual attestation by US hospitals.

Objectives: This case study describes how SAFER Guide recommendations were updated to align with current evidence and clinical practice.

Materials and methods: Over nine months, a multidisciplinary team updated SAFER Guides through literature reviews, iterative feedback, and online meetings.

Results: We reduced …

Crispr/Cas9 Gene Therapy Increases The Risk Of Tumorigenesis In The Mouse Model Of Hereditary Tyrosinemia Type I, Tong Chen, Mercedes Barzi, Nika Furey, Hyunjae R Kim, Francis P Pankowicz, Xavier Legras, Sara H Elsea, Ayrea E Hurley, Diane Yang, David A Wheeler, Malgorzata Borowiak, Beatrice Bissig-Choisat, Pavel Sumazin, Karl-Dimiter Bissig

Center for Medical Ethics and Health Policy Staff Publications

Background & aims: The therapeutic potential of CRISPR gene editing has been demonstrated in various animal models; however, little is known about its long-term consequences. This study seeks to bridge this gap by investigating the lasting consequences of CRISPR gene therapy in an animal model of hereditary tyrosinemia type I (HT-I). We compared the standard of care-nitisinone, a small molecule inhibitor of hydroxyphenylpyruvate dioxygenase (HPD)-with the deletion of the Hpd gene by CRISPR gene therapy. Both treatments block flux through tyrosine catabolism and thereby prevent the accumulation of toxic catabolites in HT-I.

Methods: We assessed the efficacy and safety of …

Amniocentesis In Pregnancies At Or Beyond 24 Weeks: An International Multicenter Study, Roni Zemet, Mohamad Ali Maktabi, Alexandra Tinfow, Jessica L Giordano, Thomas M Heisler, Qi Yan, Roni Plaschkes, Jenny Stokes, Jennifer M Walsh, Siobhán Corcoran, Erica Schindewolf, Kendra Miller, Asha N Talati, Kristen A Miller, Karin Blakemore, Kate Swanson, Jana Ramm, Ivonne Bedei, Teresa N Sparks, Angie C Jelin, Neeta L Vora, Juliana S Gebb, David A Crosby, Michal Berkenstadt, Boaz Weisz, Ronald J Wapner, Ignatia B Van Den Veyver

Center for Medical Ethics and Health Policy Staff Publications

Background: Amniocentesis for genetic diagnosis is most commonly done between 15 and 22 weeks of gestation but can be performed at later gestational ages. The safety and genetic diagnostic accuracy of amniocentesis have been well-established through numerous large-scale multicenter studies for procedures before 24 weeks, but comprehensive data on late amniocentesis remain sparse.

Objective: To evaluate the indications, diagnostic yield, safety, and maternal and fetal outcomes associated with amniocentesis performed at or beyond 24 weeks of gestation.

Study design: We conducted an international multicenter retrospective cohort study examining pregnant individuals who underwent amniocentesis for prenatal diagnostic testing at gestational ages …

Data Driven Multi-Objective Optimization Of The Scheduling For Towing A Floating Offshore Wind Turbine Between Assembly Port And Installation Location Throughout A Year, Frédéric Le Pivert, Adam Roberts, Adan Lopez-Santander, Matthew Craven, Saeid Kazemi

School of Engineering, Computing and Mathematics

High demand for the installation of floating offshore wind turbines over the coming years is likely to place significant pressure on ports and installation vessels. Optimization of the routes between ports and farms and the towing schedule when transporting equipment is therefore critical to reducing operation timescales and carbon emissions. This paper presents two series of multi-objective optimizations for minimizing the timescale and carbon emissions for the case of an IEA 15 MW turbine on a VolturnUS-S platform being wet towed through the English Channel to the Celtic Sea. The study makes use of the Maritime Simulation Laboratory (MSL) Ship …

Machine Learning To Predict Stroke Risk From Routine Hospital Data: A Systematic Review, William Heseltine-Carp, Megan Courtman, Daniel Browning, Aishwarya Kasabe, Michael Allen, Adam Streeter, Emmanuel Ifeachor, Martin James, Stephen Mullin

School of Engineering, Computing and Mathematics

Purpose: Stroke remains a leading cause of morbidity and mortality. Despite this, current risk stratification tools such as CHA₂DS₂-VASc and QRISK3 are of limited accuracy, particularly in those without a diagnosis of atrial-fibrillation. Hence, there is a need for more accurate stroke risk prediction models. Machine-learning (ML) may provide a solution to this by leveraging existing routine hospital databases to build accurate stroke risk prediction models and identify novel risk factors for stroke. Aims: In this systematic review we appraise current research using ML to predict stroke risk from routine hospital data. Based on these findings …

Preparing To Implement Shared Decision Making In Anaesthesia For Hip Fracture Surgery: A Qualitative Interview Study, Eliana C Goldstein, Mark D Neuman, Viktoria Vonder Haar, Aaron C Li, Carlos E Guerra-Londono, Glyn Elwyn, Stacie G Deiner, Adnan Hussain, Joshua W Sappenfield, Christopher J Edwards, Sabry Ayad, James H Baraldi, Karah Whatley, Mary C Politi

2020-Current year OA Pubs

BACKGROUND: Shared decision making is rarely used in anaesthesia consultations. Because either spinal or general anaesthesia can be appropriate for many patients undergoing surgery to repair a hip fracture, this is an appropriate context to implement and test shared decision making and associated resources for anaesthesia decisions. Conversation aids can facilitate shared decision making between clinicians, patients, and caregivers about treatment choices.

METHODS: We conducted semi-structured qualitative interviews at seven sites from April to September 2024 to prepare for implementation of a conversation aid about anaesthesia choices for hip fracture surgery. Interviews elicited feedback on shared decision making and a …

Hypertension Diagnosis And Management In Bamako, Mali, Issiaka Camara, Mohamed Traore, Mamoudou Maiga, Dike Ojji, Jane Holl, Souleymane Coulibaly, Mark D Huffman

2020-Current year OA Pubs

PROBLEM: The capacity and site readiness for delivering hypertension management services in Mali were unknown, hindering the effective implementation of the World Health Organization (WHO) HEARTS technical package for cardiovascular disease management.

APPROACH: We selected one tertiary and two secondary hospitals to be assessed. From December 2021 to January 2022, hospital cardiologists collected data on indicators of capacity and site readiness using an adapted version of the WHO service availability and readiness assessment questionnaire. The study team verified the collected data through site inspection and review of administrative documents.

LOCAL SETTING: Mali, a low-income country with a population of 22 …

Quantitative And Visual Benefits Of Data-Driven Motion Correction On Oncologic Pet/Ct: A Prospective Cross-Sectional Study, Semra Ince, M Allan Thomas, Malak Itani, Christopher Swingle, Richard Laforest, Adeel Haq, Genevieve Muñoz, Saeed Ashrafinia, Paul Schleyer, Richard L Wahl, Tyler J Fraum

2020-Current year OA Pubs

RATIONALE AND OBJECTIVE: Conventional positron emission tomography (PET) respiratory gating utilizes a fraction of acquired PET counts (i.e., optimal gate [OG]), whereas elastic motion correction with deblurring (EMCD) utilizes all PET counts to reconstruct motion-corrected images without increasing image noise. Our aim was to assess the quantitative and visual impacts of EMCD-based motion correction on FDG-PET and DOTATATE-PET images relative to OG and ungated (UG) images.

MATERIALS AND METHODS: This prospective, single-center study enrolled adults undergoing FDG or DOTATATE oncologic PET/CT between June 2020 and October 2022. Subjects underwent a standard-of-care (SOC) PET acquisition while wearing a respiratory gating belt. …

Femoral Nail And Cement Static Spacer Technique For The Treatment Of Chronic Periprosthetic Knee Infection, Katherine Mistretta, Caroline Granger, Joseph Kromka, Andrew M Schneider

2020-Current year OA Pubs

A 2-stage protocol is standard of care treatment in the United States for chronic periprosthetic joint infection of the knee. While many patients benefit from insertion of an articulating spacer, there are instances in which this is not feasible, and a static spacer is indicated. However, many static spacer techniques risk instability and lack durability. The ideal static spacer construct should provide immediate brace-free weight-bearing to maximize function during the spacer stage and, if needed, permit delayed reimplantation in the case of medically high-risk patients. Here, we describe our surgical technique for a femoral nail and cement static spacer in …

Single-Cell Transcriptomic Analysis Of Kaposi Sarcoma, Daniel A. Rauch, Paula Valiño Ramos, Mariam Khanfar, John Harding, Ancy Joseph, Anam Fahad, Paul Simonson, Isabel Risch, Obi Griffith, Malachi Griffith, Lee Ratner

2020-Current year OA Pubs

Kaposi Sarcoma (KS) is a complex tumor caused by KS-associated herpesvirus 8 (KSHV). Histological analysis reveals a mixture of "spindle cells", vascular-like spaces, extravasated erythrocytes, and immune cells. In order to elucidate the infected and uninfected cell types in KS tumors, we examined twenty-five skin and blood samples from sixteen subjects by single cell RNA sequence analyses. Two populations of KSHV-infected cells were identified, one of which represented a CD34-negative proliferative fraction of endothelial cells, and the second representing CD34-positive cells expressing endothelial genes found in a variety of cell types including high endothelial venules, fenestrated capillaries, and endothelial tip …

The Role Of Androgens On Experimental Pain Sensitivity: A Systemic Review And Meta-Analysis, Elizabeth Wu-Chen, Gourav Banerjee, Elise Requadt, Benjamin Hunter, Thomas J. Baranski, Whitney Trotter Ross, Hadas Nahman-Averbuch

2020-Current year OA Pubs

Animal studies have shown androgens, especially testosterone, may have an analgesic effect on nociceptive behavior. However, it is unclear if this effect is present in humans. This review and meta-analysis aim to summarize and synthesize the role of androgens on experimental pain sensitivity in humans. Studies were included if they examined the (1) relationships between androgens and experimental pain sensitivity, (2) group differences in androgen or pain levels, and (3) the effect of androgen interventions on experimental pain sensitivity. After a comprehensive search, 31 papers were identified. When possible, meta-analyses were performed. Most studies examined the impact of testosterone on …

Thrombotic Microangiopathy After Kidney Transplantation: Insights Into Genetic Etiology And Clinical Outcomes, Massini Merzkani, Nyein Chann Wai Lynn, Karen Flores, Gaurav Rajashekar, Kristin Progar, Rowena Delos Santos, John P Atkinson, Daniel C Brennan, Anuja Java

2020-Current year OA Pubs

INTRODUCTION: Thrombotic microangiopathy (TMA), characterized by small-vessel thrombosis caused by endothelial injury, presents significant diagnostic and treatment challenges in kidney transplantation.

METHODS: To investigate the factors associated with posttransplant TMA, we conducted a retrospective study of 3535 kidney transplant recipients at our center from 2008 to 2023.

RESULTS: Sixty-eight patients were diagnosed with TMA, and 93% (63 of 68) underwent genetic testing. Patients were categorized into 3 groups based on the TMA etiology. Group 1 (

CONCLUSION: Our findings underscore the need for comprehensive pre and posttransplantation genetic testing to predict and manage the risk of TMA and prevent graft …

Severe Aortic Stenosis And Chronic Myeloid Leukemia: Considerations For Valve Management, Rebecca Cunningham, Sang Gune K Yoo, Alexander A Brescia, Karolyn A Oetjen, Iskra Pusic, Joshua D Mitchell

2020-Current year OA Pubs

No abstract provided.