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Lost In Stratification: The Underutilization Of Fib-4-Guided Masld Screening In The Primary Care Setting, Sanjna Shelukar, Md, Ananya Venkatesh, Md, Breanne Mcdermott, Bs, Julietta Gervase, Ba, Maria Winte, Md, Rebecca Loh, Md, Dina Halegoua-De Marzio, Md Jul 2026

Lost In Stratification: The Underutilization Of Fib-4-Guided Masld Screening In The Primary Care Setting, Sanjna Shelukar, Md, Ananya Venkatesh, Md, Breanne Mcdermott, Bs, Julietta Gervase, Ba, Maria Winte, Md, Rebecca Loh, Md, Dina Halegoua-De Marzio, Md

The Medicine Forum

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a leading contributor to chronic liver disease worldwide. Early identification of MASLD and hepatic fibrosis in the primary care setting is essential for timely and effective management. The Fibrosis-4 (FIB-4) index is recommended as a first-line, non-invasive tool to screen at-risk patients for advanced fibrosis. This study aims to determine FIB-4 screening rates in at-risk patients in an urban resident-led primary care clinic.

A retrospective chart review was conducted in a single Internal Medicine resident-led primary care clinic. Patients aged 36 to 65 years were included, and FIB-4 scores were calculated. Patients were …


Foreword From Faculty Advisor, Dagan Coppock, Md, Msce Jul 2026

Foreword From Faculty Advisor, Dagan Coppock, Md, Msce

The Medicine Forum

We are honored to present this latest edition of The Medicine Forum. This platform is in its twenty-seventh year serving as an outlet for our medical community’s scholarly and creative efforts. This year, it has been my pleasure to work with Nehar, Jasmine, Hamzah, and Allison on this project. It has been impressive to see them balance their efforts on this scholarly work with their efforts on the wards.

As a Department, we are a productive group of writers, thinkers, scientists, and artists, who send out our work for publication in the larger medical community. What makes The Medicine …


From The Chief Residents, Brian Schonewald, Md, Beatriz Torre, Md, Chukwuemezie Mamanu, Md, Julia Palecki, Md Jul 2026

From The Chief Residents, Brian Schonewald, Md, Beatriz Torre, Md, Chukwuemezie Mamanu, Md, Julia Palecki, Md

The Medicine Forum

As the current Chief Residents, we beam with pride at the 27th edition of The Medicine Forum – a culmination of the passion, hard work, and talent of the residents of the Thomas Jefferson Internal Medicine Residency Program. We believe that The Medicine Forum stands as a testament to the fact that our residents are not only outstanding clinicians and medical educators, but also excel across all facets of medicine, including research, quality improvement, and the humanities.

We applaud our talented and driven Chief Editors, Nehar Damle, Hamzah Shariff, Allison Kayne, and Jasmine Lee, who worked diligently to ensure the …


From The Editors, Nehar Damle, Md, Pharmd, Hamzah Shariff, Md, Allison Kayne, Md, Jasmine Lee, Md Jul 2026

From The Editors, Nehar Damle, Md, Pharmd, Hamzah Shariff, Md, Allison Kayne, Md, Jasmine Lee, Md

The Medicine Forum

As physicians in training, much of our work is shaped by immediacy – responding to evolving clinical situations, navigating diagnostic uncertainty, and making decisions with present information. In this environment, it can be easy to prioritize action over reflection. Yet it is through reflection, inquiry, and shared scholarship that we deepen our understanding of medicine and the patients we serve.

It is within this spirit that we present Volume 27 of The Medicine Forum. This publication represents not only scholarly achievement, but also the intellectual curiosity and dedication that define our community.

This year, we were particularly struck by …


The Medicine Forum: Volume 27 Jul 2026

The Medicine Forum: Volume 27

The Medicine Forum

The Journal of Thomas Jefferson University Hospital - Department of Internal Medicine, Volume 27, 2025-2026

TABLE OF CONTENTS

  • Case Reports
  • Letter to the Editor
  • Research Studies
  • Humanities & Reflections


When Brand Image Stabilizes Uncertainty: Towards Digital And Inclusive Strategies Based On Artificial Intelligence, Rhita Serir, Raja Temnati Jul 2026

When Brand Image Stabilizes Uncertainty: Towards Digital And Inclusive Strategies Based On Artificial Intelligence, Rhita Serir, Raja Temnati

Revue Marocaine de Droit, d'Economie et de Gestion (Moroccan Journal of Law, Economics and Management)

In a context of profound transformation, contemporary marketing is evolving rapidly under the combined influence of digital transformation, artificial intelligence and Generation Z, whose behaviours are redefining consumption and communication norms. At the same time, the COVID-19 pandemic, global recession and market instability have increased the complexity and uncertainty faced by businesses. Strategic decision-making is becoming increasingly complex as technological tools multiply and consumer expectations diversify. Brand managers must therefore maintain coherence, relevance and credibility in unstable environments. Digital marketing emerges as a key strategic lever: integrating digital tools and artificial intelligence into communication and positioning strategies can improve audience …


The Effect Of Environmental Frugal Innovation On Consumers’ Eco-Responsible Behaviour In Togo, Preabalo Essokobré N’Danida, Doman Gnoufougou Jul 2026

The Effect Of Environmental Frugal Innovation On Consumers’ Eco-Responsible Behaviour In Togo, Preabalo Essokobré N’Danida, Doman Gnoufougou

Revue Marocaine de Droit, d'Economie et de Gestion (Moroccan Journal of Law, Economics and Management)

This research examines the effect of environmental frugal innovation on consumers' eco-responsible behaviour. A mixed approach was adopted, using a questionnaire and a non-probability convenience sampling technique. Structural equation modelling results show that three dimensions—cost efficiency, functional simplicity and local embeddedness—have a positive and significant effect on consumers' eco-responsible behaviour, validating the corresponding hypotheses. By contrast, environmental impact and social impact do not show significant effects. The study concludes by identifying limitations and suggesting future research directions, particularly on how accessible and locally adapted innovations can encourage more responsible consumption in developing countries.


Human Capital, Gender And Labour Market Duality In Morocco: A Comparative Analysis Of Wage Earners And Non-Agricultural Self-Employed Workers, Zineb Nahmed, Malika Nahmed, Abdeljaoaud Ezzrari Jul 2026

Human Capital, Gender And Labour Market Duality In Morocco: A Comparative Analysis Of Wage Earners And Non-Agricultural Self-Employed Workers, Zineb Nahmed, Malika Nahmed, Abdeljaoaud Ezzrari

Revue Marocaine de Droit, d'Economie et de Gestion (Moroccan Journal of Law, Economics and Management)

This article provides a comparative analysis of the socioeconomic situation of wage earners and non-agricultural self-employed workers in Morocco, based on data from the 2019/2020 National Survey on Sources of Income. Drawing on human capital theory, labour market segmentation, the institutional approach to informality and gender theories, the study highlights the inequality dynamics shaping access to employment, social protection and income. The results show that human capital has a positive effect on income, but that this effect is stronger among wage earners than among self-employed workers, who are often confined to informality. Labour market duality is particularly marked between formal …


Women Managers And Employee Well-Being In Guinea: What Role Does The Iglo Model Play In Workplace Resources?, Zinsou Daniel Nakou, Fatoumata Ibrahima Camara, Ibrahima Bah, Serge Francis Simen Nana Jul 2026

Women Managers And Employee Well-Being In Guinea: What Role Does The Iglo Model Play In Workplace Resources?, Zinsou Daniel Nakou, Fatoumata Ibrahima Camara, Ibrahima Bah, Serge Francis Simen Nana

Revue Marocaine de Droit, d'Economie et de Gestion (Moroccan Journal of Law, Economics and Management)

This research examines the impact of women managers on employee well-being through a mediation model introducing the IGLO framework of workplace resources at the individual, group, leadership and organizational levels. The study adopts a quantitative hypothetico-deductive approach using data collected from 100,000 observations between 2022 and 2024 and processed with SPSS. The results show that a higher proportion of women managers is associated with improved employee well-being, notably through reduced work stress, higher work engagement, greater job satisfaction and stronger workplace cohesion. More broadly, women managers can act as agents of change by improving workplace resources at several levels, including …


Islamic Fintech And Financial Inclusion In Morocco: Perceptions, Uses And Prospects, Inas Bennani, Said Lotfi Jul 2026

Islamic Fintech And Financial Inclusion In Morocco: Perceptions, Uses And Prospects, Inas Bennani, Said Lotfi

Revue Marocaine de Droit, d'Economie et de Gestion (Moroccan Journal of Law, Economics and Management)

Islamic FinTech is considered a potential lever for financial inclusion. This study identifies the factors that hinder or promote its development in Morocco. Using a mixed methodology, an online questionnaire was completed by 70 professionals from the financial, technological, institutional and academic sectors. Quantitative data were processed using SPSS, while responses to open-ended questions were analysed thematically using the framework proposed by Braun and Clarke (2006). This dual approach demonstrates the potential of Islamic FinTech in Morocco in terms of inclusion, particularly among entrepreneurs and women. The results point to barriers to adoption, including limited financial education, inadequate regulation and …


Microfinance And Financial Inclusion: A Multilevel Analysis Of Barriers Related To Repayment Delays According To Individual And Regional Profiles – The Case Of Al Amana Microfinance, Meryem Massine, Hajar El-Mahdad, Youssef Bouazizi Jul 2026

Microfinance And Financial Inclusion: A Multilevel Analysis Of Barriers Related To Repayment Delays According To Individual And Regional Profiles – The Case Of Al Amana Microfinance, Meryem Massine, Hajar El-Mahdad, Youssef Bouazizi

Revue Marocaine de Droit, d'Economie et de Gestion (Moroccan Journal of Law, Economics and Management)

This article examines the determinants of repayment delays in Moroccan microfinance using an original administrative database of 476,145 borrowers financed by Al Amana between 2010 and 2022. Combining count models and a multilevel approach, the analysis shows that repayment discipline results from a combination of individual, contractual and territorial factors. The findings indicate that women, older borrowers, more educated clients and borrowers with accumulated credit experience have significantly fewer arrears, while larger loan amounts, some marital profiles and agricultural activities increase the risk of delay. The multilevel model shows that 6.49% of the variance in arrears is explained by regional …


Towards Broader Responsibility? A Quasi-Experimental Analysis Of The Effect Of Foreign Ownership On Corporate Social Practices In Morocco, Youssef Bouazizi, Adil Cherkaoui, Mohammed Ghazouani Jul 2026

Towards Broader Responsibility? A Quasi-Experimental Analysis Of The Effect Of Foreign Ownership On Corporate Social Practices In Morocco, Youssef Bouazizi, Adil Cherkaoui, Mohammed Ghazouani

Revue Marocaine de Droit, d'Economie et de Gestion (Moroccan Journal of Law, Economics and Management)

This article examines the impact of foreign ownership on firms' social performance in Morocco, a context marked by increasing non-financial requirements and an institutional framework still under development. Using World Bank Enterprise Survey data for 2013, 2019 and 2023, the study builds a composite social performance index focused on gender equality, continuous training and human capital development. To address selection bias linked to foreign ownership, the study applies propensity score matching to estimate the average treatment effect. The findings show that firms partially or majority-owned by foreign investors have significantly higher levels of social performance than comparable domestic firms. This …


Sustainable Solutions For Food Security In Djibouti: A Renewable Energy Initiative, Michaëlle Arielle Kouakep Tsoh, Tsoh Ekassi Gilbert, Thierry Césaire Kenmogne, Brice Pinga Tcheugoué, Justin Kouamo Jul 2026

Sustainable Solutions For Food Security In Djibouti: A Renewable Energy Initiative, Michaëlle Arielle Kouakep Tsoh, Tsoh Ekassi Gilbert, Thierry Césaire Kenmogne, Brice Pinga Tcheugoué, Justin Kouamo

Revue Marocaine de Droit, d'Economie et de Gestion (Moroccan Journal of Law, Economics and Management)

According to the World Bank Group, East African countries have fragile food systems and low agricultural production. Djibouti is among the most undernourished countries in Africa and is severely affected by freshwater scarcity. Households regularly face climatic shocks and high electricity costs. This literature review characterizes Djibouti’s food systems and food security situation, identifies and analyzes renewable energy technologies implemented to improve food security in the local context, and presents renewable technologies as sustainable solutions to food insecurity. The results show that rural households are more likely to be food insecure and that the Djiboutian government promotes sustainable energy solutions. …


Reconfiguring Civil Society Organization Governance Models For Social Inclusion And Sustainable Innovation: Practical Contributions Of The Tamuri Programme, Oussama El Hadfi, Mostafa Kharbachi Jul 2026

Reconfiguring Civil Society Organization Governance Models For Social Inclusion And Sustainable Innovation: Practical Contributions Of The Tamuri Programme, Oussama El Hadfi, Mostafa Kharbachi

Revue Marocaine de Droit, d'Economie et de Gestion (Moroccan Journal of Law, Economics and Management)

Today, civil society organizations (CSOs) play a decisive role in promoting social innovation and reducing inequalities, particularly in disadvantaged territories. Aware of their potential, several support and guidance schemes have emerged to strengthen their impact. The Tamuri programme, led by the Moroccan Center for Innovation and Social Entrepreneurship (MCISE) and co-funded by the European Union, is part of this dynamic through structured and personalized support for CSOs from diverse territorial contexts. Despite these efforts, many organizations still face difficulties related to governance, financial structuring and the sustainability of their actions. This article aims to analyze, through an empirical approach and …


Comparative Approach To Inclusion Models In Social Policies In Mena Countries, Taoufik El Idrissi, Omar Raji, Zouhir Tassi, Anas Ouachani Jul 2026

Comparative Approach To Inclusion Models In Social Policies In Mena Countries, Taoufik El Idrissi, Omar Raji, Zouhir Tassi, Anas Ouachani

Revue Marocaine de Droit, d'Economie et de Gestion (Moroccan Journal of Law, Economics and Management)

Social inclusion policies in Global South countries vary widely according to political choices, historical contexts and development models. This paper provides a comparative analysis of inclusion models in social policies in the MENA region, drawing on human development theories and comparative institutionalism. It discusses three main paradigms: universalist inclusion, targeted inclusion and capacity-based inclusion. The analysis shows how inclusion logics are shaped by international agendas, internal political configurations and interactions between civil society and public actors. It also highlights the strengths and limits of each model in reducing social inequalities and opens a discussion on hybrid, locally grounded inclusive policies.


Editorial : Rethinking Public Policies And Management Practices Through The Lens Of Inclusion And Social Innovation, Fatima Zahra Alami, Adil Cherkaoui, Abdellatif Komat, Raja Temnati Jul 2026

Editorial : Rethinking Public Policies And Management Practices Through The Lens Of Inclusion And Social Innovation, Fatima Zahra Alami, Adil Cherkaoui, Abdellatif Komat, Raja Temnati

Revue Marocaine de Droit, d'Economie et de Gestion (Moroccan Journal of Law, Economics and Management)

This editorial introduces a special issue of the Moroccan Journal of Law, Economics and Management (REMADEG) devoted to selected contributions from the international conference “Rethinking Public Policies and Management Practices through the Lens of Inclusion and Social Innovation”, held on 13–14 February 2026 at the Faculty of Legal, Economic and Social Sciences of Ain Chock, Hassan II University of Casablanca. It presents the scientific context of the issue, the rigorous double-blind review process, and the main themes addressed by the eleven selected articles, including financial inclusion, social responsibility, public policy, social entrepreneurship, governance, territorial development and the inclusion of vulnerable …


Abdellatif Laâbi’S Hyperesthesia Between Reality And Imagination, Zineb Amermouch Jul 2026

Abdellatif Laâbi’S Hyperesthesia Between Reality And Imagination, Zineb Amermouch

SOROUD: The journal of Literacy Criticism

Thanks to hyperesthesia, the “poet-detainee” manages to pierce the opacity of his cell, to tear the black band and to master an unhealthy environment that is completely foreign to him. In his poems written during the years of lead (1972- 1980), Abdellatif Laâbi immortalized eight years in prison. He is more than a political prisoner; he is a poet who cannot be intimidated, let alone deprived of imagination and writing. However, faced with the arbitrariness of the prison machination, he is reduced to a sequestered state. Thus, like any prisoner, he is affected by the hyperesthesia inherent in the condition …


The Impact Of International Organizations On The Development And Enforcement Of International Humanitarian Law, Mubeen Majid Jaber Jul 2026

The Impact Of International Organizations On The Development And Enforcement Of International Humanitarian Law, Mubeen Majid Jaber

Imam Ja'afar Al-Sadiq University Journal of Legal Studies

The struggle for survival and human dignity continues in Syria, Yemen, and Ukraine amid ongoing armed conflicts, while international organizations seek to uphold International Humanitarian Law (IHL). In many instances, the enforcement of humanitarian law falls short of established standards. Organizations such as the United Nations (UN), the International Committee of the Red Cross (ICRC), and the International Criminal Court (ICC) play vital roles in promoting and implementing humanitarian principles and protecting human rights. However, their effectiveness often depends on political cooperation and the existence of conditions conducive to peace. This study examines selected case studies to evaluate how political …


Machine Learning-Based Forecasting Of Energy Consumption In A Nigerian Tertiary Institution, O. A. Adebimpe, S. S. Showunmi, F. T. Adedeji Jul 2026

Machine Learning-Based Forecasting Of Energy Consumption In A Nigerian Tertiary Institution, O. A. Adebimpe, S. S. Showunmi, F. T. Adedeji

Engineering and Technology Journal

An accurate electricity consumption forecast is key to effective energy planning and management in Nigerian tertiary institutions. While applications of machine learning (ML) in forecasting have increased, their deployment in predicting energy consumption in Nigerian tertiary institutions has been limited. Also, the significance of weather-related variables, academic and non-academic activities, and the staff and students' population in predicting energy consumption at a tertiary institution has been underexplored. This study addresses these by developing and evaluating six forecasting models, including Seasonal Autoregressive Integrated Moving Average with Exogenous Variables (SARIMAX), Support Vector Regression (SVR), Artificial Neural Network (ANN), Extreme Gradient Boosting (XGBoost), …


Effect Of Higher-Alcohol/Gasoline Blends On Performance, Acoustic Characteristics, And Emissions Of A Spark-Ignition Engine, Isam E. Yousif, Adel M. Saleh Jul 2026

Effect Of Higher-Alcohol/Gasoline Blends On Performance, Acoustic Characteristics, And Emissions Of A Spark-Ignition Engine, Isam E. Yousif, Adel M. Saleh

Engineering and Technology Journal

Future studies offer many solutions to reduce problems from internal combustion engines; one is the use of blended fuels containing alcohols. This research aimed to investigate the effect of blending Iraqi regular gasoline with heavy alcohols, such as 1-butanol and 1-octanol, by conducting experiments on a 4-cylinder spark-ignition (SI) engine. The first goal is to prepare a blended gasoline consisting of 88% regular gasoline, 6% 1-butanol, and 6% 1-octanol by mass, and to use it for thermal analysis of engine operation. This work fills a gap by experimentally evaluating a mixed mid- and long-chain alcohol blend (1-butanol/1-octanol) with gasoline, an …


Effect Of Graphite-Mwcnt Hybrid Nanofluid Mql On Cutting Force During Turning Of Ti-6al-4v Alloy, Abbas Ibrahim Khwakaram, Yassin Mustafa Ahmed, Muhammed Tahir Muhammed Jul 2026

Effect Of Graphite-Mwcnt Hybrid Nanofluid Mql On Cutting Force During Turning Of Ti-6al-4v Alloy, Abbas Ibrahim Khwakaram, Yassin Mustafa Ahmed, Muhammed Tahir Muhammed

Engineering and Technology Journal

Titanium alloys are popular in the aerospace and medical fields because they are very robust but difficult to work with. The study was carried out on a hybrid nanofluid (graphite and MWCNTs, in sunflower oil) under minimum quantity lubrication (MQL) conditions. Unlike conventional lubrication methods, hybrid nano-additives reduce cutting forces during turning. The Taguchi L18 orthogonal array was employed to study the effects of cutting speed, feed rate, and cooling conditions on cutting force. The ``smaller-is-better'' rule was applied to convert the average cutting force into signal-to-noise S/N ratios. ANOVA was used to determine the extent to which each factor …


Diagnostic And Clinical Management Performance Of Large Language Models In Pediatric Infectious Diseases: A Multi-Model Comparative Cross-Sectional Study With Healthcare Professionals And Medical Students, Sait Ramazan Gülbay, Muhammed Yusuf Ozan Avcı, Muhammed Nezih Koç, Hanife Tutan, Sümeyye Koç, Ömer Adil İlhan, Metin Doğan Jul 2026

Diagnostic And Clinical Management Performance Of Large Language Models In Pediatric Infectious Diseases: A Multi-Model Comparative Cross-Sectional Study With Healthcare Professionals And Medical Students, Sait Ramazan Gülbay, Muhammed Yusuf Ozan Avcı, Muhammed Nezih Koç, Hanife Tutan, Sümeyye Koç, Ömer Adil İlhan, Metin Doğan

Journal of Pediatric Infectious Diseases

Objective: Large language models (LLMs) are increasingly investigated to support clinical decision-making. However, their comparative performance against human expertise in pediatric infectious diseases remains insufficiently characterized. This study compared diagnostic accuracy and management score between healthcare professionals, medical students, and multiple LLM configurations. Methods: A cross-sectional comparative study was conducted using 30 standardized pediatric infectious disease cases stratified by difficulty (6 easy, 12 medium, 12 difficult). Each case included three multiple-choice questions: a diagnostic gateway question and two management questions. A conditional scoring framework was applied: management questions were scored only when the diagnostic gateway question was answered correctly. The …


Risk Factors Associated With Poor Prognosis In Children With Severe Pneumonia And Their Clinical And Nursing Implications, Chao Fan, Jiarong Li, Jiao Yuan Jul 2026

Risk Factors Associated With Poor Prognosis In Children With Severe Pneumonia And Their Clinical And Nursing Implications, Chao Fan, Jiarong Li, Jiao Yuan

Journal of Pediatric Infectious Diseases

Objective: Severe pneumonia (SP) accompanied by high fever is frequently encountered in pediatric emergency and intensive care settings and is associated with unfavorable short-term outcomes. Early identification of factors associated with poor prognosis may support timely risk recognition and nursing awareness. Methods: This retrospective observational study included 195 children with SP complicated by high fever who were admitted to the Pediatric Intensive Care Unit (PICU) or the Emergency Department of our hospital between January 2019 and January 2022. Demographic characteristics, baseline clinical indicators, and laboratory parameters at admission were extracted from medical records. Poor prognosis was determined according to predefined …


Serum Igf-1 And Igfbp-3 In Preschool Children With Adjudicated Sepsis: A Retrospective Case–Control Study, Wei Pan, Wenwen Zhang Jul 2026

Serum Igf-1 And Igfbp-3 In Preschool Children With Adjudicated Sepsis: A Retrospective Case–Control Study, Wei Pan, Wenwen Zhang

Journal of Pediatric Infectious Diseases

Objective: Sepsis in children is accompanied by marked inflammatory and metabolic perturbations. Conventional markers such as C-reactive protein (CRP) and procalcitonin (PCT) reflect inflammation but do not capture broader endocrine–metabolic responses. We therefore examined serum insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) in preschool children with retrospectively adjudicated sepsis and explored their in-sample discriminatory ability within this dataset. This study was exploratory and was not designed to validate clinically actionable biomarkers. Methods: We conducted a retrospective case–control study of 73 children aged 4–6 years with retrospectively adjudicated sepsis and 80 age- and sex-matched healthy controls. For …


Epstein-Barr Virus Infection In Children Of Hangzhou During Strict And Optimized Covid-19 Control Periods: Epidemiological Characteristics And Variation Distributions, Hao Wang, Lin Chen, Shuangshuang Huang, Zhijian Song, Chunhong Zhu, Tong Wang, Fengqing Cai, Zhaoyang Peng, Hongqiang Shen Jul 2026

Epstein-Barr Virus Infection In Children Of Hangzhou During Strict And Optimized Covid-19 Control Periods: Epidemiological Characteristics And Variation Distributions, Hao Wang, Lin Chen, Shuangshuang Huang, Zhijian Song, Chunhong Zhu, Tong Wang, Fengqing Cai, Zhaoyang Peng, Hongqiang Shen

Journal of Pediatric Infectious Diseases

Objective: Epstein-Barr virus (EBV) infection is linked to multiple pediatric disorders, and COVID-19 control measures may have modified its epidemiological profiles. This study analyzed EBV infection characteristics and distribution changes among children in Hangzhou before and after the promulgation of the ‘10 prevention and control measures,’ comparing the strict (2022) and relaxed (2023) pandemic periods. Methods: A retrospective analysis was conducted on 38,086 children with suspected EBV-related diseases who underwent EBV serological antibody testing via chemiluminescence immunoassay at Children's Hospital of Zhejiang University School of Medicine between January 2022 and December 2023. The percentages and distributions of Seropositive across years, …


Integrating Geo Analysis And Machine Learning For Identifying Transcriptomic Signature Of Ev-A71 Infection, Li Li, Guifang Hu Jul 2026

Integrating Geo Analysis And Machine Learning For Identifying Transcriptomic Signature Of Ev-A71 Infection, Li Li, Guifang Hu

Journal of Pediatric Infectious Diseases

Objective: To identify a transcriptomic signature associated with EV-A71 infection using peripheral blood mononuclear cells (PBMC) transcriptome profiles from the public dataset GSE135964, which compares samples from subjects with Enterovirus A71 (EV-A71) infection against healthy controls based on bioinformatics and machine learning algorithms, for exploratory biomarker discovery. Methods: The publicly available dataset GSE135964, accessed through the Gene Expression Omnibus (GEO) database WAS analyzed. Differential expression analysis was conducted with a |log2FC| ≥ 0.5 and an adj.P.Val < 0.05 cutoff. The resulting gene set was then visualized through box plots, PCA, volcano plots, and heatmaps. Subsequently, we utilized the random forest algorithm, which quantified gene importance by integrating the mean decrease in both accuracy and the Gini index. This process culminated in the selection of the highest-ranking 10% of genes for subsequent candidacy. Functional characterization of the candidate genes involved Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses, alongside the establishment of a protein-protein interaction (PPI) network leveraging the STRING database. Results: Our analysis revealed 438 differentially expressed genes (DEGs), with a marked imbalance towards upregulation (415 genes) compared to downregulation (23 genes). Random forest screening identified 44 candidate genes. PPI analysis identified 23 key genes, and LASSO regression finally pinpointed three feature genes: IFIT5, OASL, and PLSCR1. ROC analysis showed AUC values of 0.964, 0.921, and 0.894 for OASL, PLSCR1, and IFIT5, respectively, indicating a strong association with EV-A71 infection. Enrichment analysis implicated these feature genes in antiviral biological processes, suggesting a core mechanism involving antiviral defense (GO:0051607) to viral RNA binding (GO:0003727). Conclusions: The identified three-gene signature, enriched in antiviral response pathways, provides a theoretical basis for future research into host transcriptomic responses to EV-A71 infection and the RIG-I signaling axis. This transcriptomic signature analysis offers an exploratory resource for understanding EV-A71–associated HFMD.


Balancing Diagnostic Accuracy And Antimicrobial Stewardship In Neonatal Sepsis, Jeslyn Tengkawan, Mmdeah Hapsari, Dimas Tri Anantyo, Helmia Farida, Adhie Nur Radityo, Moh Syarofil Anam, Seda Yilmaz Semerci Jul 2026

Balancing Diagnostic Accuracy And Antimicrobial Stewardship In Neonatal Sepsis, Jeslyn Tengkawan, Mmdeah Hapsari, Dimas Tri Anantyo, Helmia Farida, Adhie Nur Radityo, Moh Syarofil Anam, Seda Yilmaz Semerci

Journal of Pediatric Infectious Diseases

Objective: Neonatal sepsis continues to be a major cause of morbidity and mortality globally, particularly in developing countries. The rising rate of antimicrobial resistance underscores the urgent need for reliable, practical sepsis prediction tools to optimize antibiotic use. The Sepsis Prediction Score (SPS) integrates clinical and laboratory parameters and has shown a positive impact in simplifying clinical decision-making. This study aimed to evaluate the diagnostic accuracy of the SPS in predicting late-onset sepsis (LOS) in a tertiary referral hospital in Indonesia. Methods: This diagnostic study used a cross-sectional design and was conducted at Dr. Kariadi General Hospital, using medical records …


Empirical Antibiotic Use In Children With Acute Fever: Clinical Evidence And Sociocultural Perspectives Literature Review, Hussein Moustafa Shehata, Ranya Khairy Ammar Jul 2026

Empirical Antibiotic Use In Children With Acute Fever: Clinical Evidence And Sociocultural Perspectives Literature Review, Hussein Moustafa Shehata, Ranya Khairy Ammar

Journal of Pediatric Infectious Diseases

Objective: Empirical antibiotic therapy in children with acute fever remains a controversial clinical issue. Fever is one of the most common presenting symptoms in pediatric care, yet most febrile episodes are self-limiting and attributable to viral infections. To evaluate the clinical evidence on empirical antibiotic therapy in febrile children, assess clinical outcomes, synthesize international guideline recommendations, and analyze the impact of sociocultural factors on prescribing practices. Methods: A narrative literature review was conducted using PubMed/MEDLINE, Embase, and Google Scholar (January 2014 – March 2025), supplemented by guideline databases from the World Health Organization (WHO), the European Society for Paediatric Infectious …


Late-Onset Cobalamin C Deficiency Associated Atypical Hemolytic Uremic Syndrome – Diagnostic Pitfalls: A Case Report, Martha Stampfli, Sibylle Tschumi, Giacomo Simonetti, Corinne Benchimol, Gabriela Oesch, Alexander Lämmle, Matthias Baumgartner Jul 2026

Late-Onset Cobalamin C Deficiency Associated Atypical Hemolytic Uremic Syndrome – Diagnostic Pitfalls: A Case Report, Martha Stampfli, Sibylle Tschumi, Giacomo Simonetti, Corinne Benchimol, Gabriela Oesch, Alexander Lämmle, Matthias Baumgartner

Journal of Child Science

Introduction: Cobalamin C (cblC) deficiency represents a rare but treatable and potentially underrecognized cause of thrombotic microangiopathy (TMA) in both pediatric and adult populations. It is a multisystem disorder with heterogeneous clinical manifestations. TMA occurs in 10-25% of affected individuals. Case presentation: A ten-year-old girl presented with vomiting and abdominal pain, followed by generalized status epilepticus and hypertensive crisis. Neuroimaging was unremarkable. Laboratory evaluation demonstrated severe renal impairment (creatinine 506 µmol/L), microangiopathic hemolysis and thrombocytopenia. Atypical hemolytic uremic syndrome (aHUS) was suspected and treated with eculizumab and intermittent hemodialysis. Genetic analysis identified biallelic pathogenic variants in the MMACHC gene, confirming …


Prevalence And Factors Associated With Depression In Pediatric Epilepsy Patients At Maharat Nakhon Ratchasima Hospital, Paneeta Panjanya, Manachawee Maneeratchakit, Vitchayaporn Emarach Saengow Jul 2026

Prevalence And Factors Associated With Depression In Pediatric Epilepsy Patients At Maharat Nakhon Ratchasima Hospital, Paneeta Panjanya, Manachawee Maneeratchakit, Vitchayaporn Emarach Saengow

Journal of Child Science

Background: Epilepsy is a chronic neurological disorder commonly associated with depressive symptoms, which can negatively affect quality of life. Early identification through screening is therefore important in pediatric epilepsy care. Objective: To determine the prevalence of depressive symptoms and associated factors among pediatric patients with epilepsy at Maharat Nakhon Ratchasima Hospital. Methods: A cross-sectional study was conducted among patients aged 10–15 years with epilepsy attending the Pediatric Epilepsy Clinic between May 2024 and June 2025. A total of 141 participants were included. Demographic, family, and epilepsy-related data were collected. Depressive symptoms were screened using the Thai version of the Children’s …